text_p,labels
"Bioinformatics Scientist 2 . Oncology bioinformatics to support CDx development . Responsibilities include data analysis and pipeline development . . I am a bioinformatics scientist with a background in human genetics . I posses strong communication skills and operate with a high level of accountability to deliver high quality analysis and tools . Specialties : human genetic data analysis , bioinformatics , population evolutionary genomics , clinical genomics , clinical variant curation and reporting , variant calling , denovo long gread genome assembly , RNA seq analysis , epitope prediction , Bayesian networks , Python , Unix , R , Rshiny , Matlab , MongoDB , Docker , AWS EC2 , Apache Spark . Technologies :",
Bioinformatics Scientist . . . Technologies :,
"Senior Scientist . . 1 Filed and published over 50 patents and papers in small molecule drug discovery 2 Devised strategies to solve difficult problems and accelerate drug discovery projects 3 Designed and synthesized DNA encoded libraries 4 Strong communication , interpersonal and project management skills . Technologies :",small molecules;screening
"Scientist . Department of Microbiology and Molecular Medicine MIMOL Ultrastructural characterization of Toxoplasma gondii parasite at different stages during the life cycle Cyst wall ultrastructure of bradyzoites stage in infected mouse brain Serial sections TEM Correlative light and electron microscopy of the brain tissue FIB SEM microscopy Electron tomography 3D reconstruction . I am electron microscopy specialist with more than 25 years hands on experience with broad range of skills and expertise especially in transmission electron microscopy TEM , in both sample preparation and results analysis . fixation glutaraldehyde , paraformaldehyde , osmium tetroxide , vitrification embedding Epon , Spurr , LR White , LR Gold , Lowicryls ultrathin sectioning plastic and cryo contrasting with uranyl acetate and lead citrate negative staining conventional and sandwich techniques quick freezing freeze drying and or fracturing metal shadowing ; glycerol spraying and low angle metal shadowing sputter coating and vacuum evaporation of C , Pt , Ta W , and Au immuno labeling both pre and post embedded colloidal gold preparation and coupling with antibody ; stereological evaluation of immuno labeled samples immunocytochemistry GraFix gradient fixation method preparation of support films for EM grid formvar , parlodion , and holey carbon film for cryo EM conventional EM and cryo EM single particle analysis and or tomography advanced user of different types of TEMs : EFTEM Omega EM912 , JEOL 1200 , 1011 , and 2010 , Phillips EM 400 , Morgagni 268 D , Tecnai T12 , F30 , and Spirit BioTWIN operation of SEMs : XLFF30 FEG FEI , Zeiss Merlin , Zeiss Nvision 40 FIBSEM data acquisition : iTEM , DigitalMicrograph , and FEI TIA image processing and visualisation : EMAN , EMAN2 , SPIDER , IMOD , FIJI , Photoshop , UCSF Chimera , ilastik , Blender Specialties : Electron microscopy techniques Immunogold labeling techniques Image acquisition and processing 2D averaging and 3D reconstruction , single particle analysis , tomography Biochemical methods SDS PAGE , Western blotting , ultracentrifugation sucrose cushion , analytical sucrose gradient , enzyme activity assay , ... Cell fractionation Cell culture macrophage RAW264.7 , fibroblast BHK 23 Mass spectrometry in gel trypsin digestion , peptide mass finger printing by MALDI TOF MS . Technologies : CryoEM;AUC",antibodies;structure
"Senior Staff Scientist in CryoEM Structural Biology . . 4 years of cryo electron microscopy cryoEM experience Negative staining and cryoEM with CM120 , CM200 , JEOL 2200FS , Arctica , and Krios 10 years of experience in protein biochemistry , biophysics , and structural biology Protein antibody expression techniques : prokaryotic expression , eukaryotic expression yeast , 293 cell line , and sf9 insect cell line Protein antibody purification techniques : affinity chromatography protein A G , Ni , GST , and MBP , ion exchange , gel filtration , etc . Protein structure determination from either X ray diffraction data or cryoEM data Crystallization of membrane proteins and protein complexes protein protein , protein peptide , protein drug , protein antibody Crystallization techniques : batch method , microbatch method , hanging or sitting drop vapor diffusion method , and seeding Biophysical and biochemical techniques : PCR , gene clone , Western blot , Native PAGE by GE PhastSystem , Dynamic Light Scattering DLS , Circular Dichroism CD , Isothermal Calorimetry ITC , BioLayer Interferometry BLI , and Analytical Ultracentrifugation AUC Anaerobic operation in COY and MBraun chamber . Technologies : Xray;CryoEM;ITC;SLS DLS;BLI;AUC;CD",antibodies;membrane proteins;peptides;proteins;characterization;interaction;structure
"Division Director , Division of Mathematical Sciences . . Administrative As DMS director , I administer a portfolio of programs with an annual budget in excess of 230 million for a division whose mission is to fund groundbreaking research in mathematics and statistics , and support education and training in the mathematical sciences . Prior to my NSF appointment , I was the Dean and primary executive officer for UC Merced 's School of Natural Sciences . Managed annual balanced budgets of over 21 million , oversaw distribution of 30 M in graduate student support , and supervised staff of 54 . Academic R D in computational sciences and mathematics . Specialties : computational mathematics , computational sciences , high performance computing , parallel programming , systems architectures , nonlinear optimization , machine learning . Technologies :",
"Tenure Track Scientist . . I am a structural biologist with my research focus to elucidate the structures of novel c di GMP and ppGpp receptors and c di GMP controlled Histidine kinases . I am employing various biochemical and biophysical techniques for functional characterization of signaling proteins in Bacteria . The investigations will contribute to the biological basis for the novel therapeutics and drug discovery . Specialties : Molecular Biology , Biophysics , Protein Biochemistry , Recombinant Protein Expression , and Purification , Protein Crystallisation , Structure Solution by X ray Crystallography , Small angle X ray scattering SAXS , Negative staining and Cryo EM . . Technologies : Xray;CryoEM",proteins;characterization;interaction;structure
"Vice President , Clinical Development . . . Technologies :",
. . MPhil candidate in Biochemistry . Passionate and self motivating in learning more knowledge about cryo electron microscopy cryo EM and Cryo ET . Interested in structural biology and relate protein functions to cellular events .. Technologies : CryoEM,proteins;structure
"Computational Biologist . . I am currently pursuing my PhD in chemistry from Stanford University . I am working on MS based proteomics research in the Snyder Lab . I have extensive experience in the technical aspects of research project development , but I am also interested in the organizational and managerial elements involved in transforming cutting edge research into successful biotechnology companies . I am particularly interested in the work carried out by biotech incubators , consulting firms and venture capital firms ; all of which sustain the ecosystem for biotechnology firms to thrive . Given my background and interest , I was further motivated to join oSTEM and SBG during my time at Stanford . oSTEM , short for Out in STEM , supports the personal and professional development of LGBTQ students pursuing careers in STEM fields . More broadly , Stanford Biotechnology Group SBG , seeks to provide professional development opportunities beyond research for the graduate community at Stanford . I am very enthusiastic about the promise of biotech and work to bring others into this exciting industry .. Technologies :",
Cryo Electron Tomography Specialist . . . Technologies : CryoEM,
"Biochemical technician . . During my bachelor 's thesis project , I have experienced production and purification of proteins causing amyloidosis 2 microglobulin and neuroserpin from E. coli and LEXSY expression system . During purification I used different chromatographic methods and SDS PAGE to analyse the efficacy of purification . I also performed circular dichroism analysis and activity tests to ensure the correct folding of proteins . I worked on my master thesis project , which consisted in purifying POMT1 2 enzyme from membranes of HEK293F cells , creating nanodiscs in order to reconstitute a physiological environment for enzyme , followed by biochemical analysis and Cryo EM in presence and absence of ligands . I also gave help in the lab 's project related to the purification of HCN2 channel , applying the same techniques as for POMT1 2 . Currently , I am working at Dia . Pro Diagnostic BioProbes s.r.l . as a lab technician in Strategic Materials section , in order to produce tracers and antigens and purifying antibodies for kit production ELISA , CLIA .. Technologies : CryoEM;CD",interaction;stability;structure
"Nottingham Research Fellow . . Bachelor and Master in Chemistry , and PhD in Biophysics and 5 years of postdoc training in modelling and simulations of biomolecules , focusing on the folding of protein and RNA . Broad knowledge of different techniques in numerical simulations and biochemistry . Skilled in Molecular Dynamics and Modeling , Programming Python , Fortran , C C , High Performance Computing using MPI and OpenMP , Data analyses .. Technologies :",
Computational Biologist . . . Technologies :,
"Associate Principal Scientist . Lead Chemist for several projects in early and late phase of drug discovery ; Medicinal Chemisty Department , Respiratory , Inflammation Autoimmunity RIA Kinase inhibitors , PPI Small molecules , PROTACs , New Modalities Using AI in drug discovery . . Technologies :",molecular glues;small molecules;developing;screening
Clinical Research Scientist . . . Technologies :,
"Research Leader Information Systems . . I 'm passionate about developing scientific software in the area of plant genetic resources , genetics and breeding . My group develops great tools ranging from the collection of experimental data in the field through to data visualization . I 'm a principal investigator for a number of open source biological database and visualization projects including the generic plant resources database Germinate and Helium for visualizing plant pedigrees . I work on a load of great projects with collaborators and funders around the world . Its great that we have excellent bioinformatics tools developed here in Scotland that are now used worldwide Looking at new tech at the moment so getting to grips with graph databases , R and Go . Always excited about what 's coming next and how we can develop my groups tools and resources to answer interesting questions or applying them to new challenges .. Technologies :",
"Scientist . Optimization of mouse lead antibodies for human therapeutics , assay development , design and implementation of automation , evaluation of new technologies , management of research operations . . I have extensive experience in design , validation and implementation of biochemical and cellular screening assays . My strengths include the utilization of binding assays and functional assays for target validation and profiling of novel small molecule and biotherapeutic agents . I am also proficient in mammalian cell culture and molecular cloning as additional support for research activities . Specialties : ELISA , HTRF , Antibody Optimization , Radioligand Binding , Cell Signaling Assays , Reporter Assays , Riboswitch In Line Probe Assays , Transcription Mediated Gel Based Assays , Lipid Metabolism Assays . Transient Stable Transfection , Creation Characterization of Clonal Cell Lines , Cultivation of Endogenous Recombinant Cell Lines . Southern , Northern , Western Blots , PCR , Primer Construction , Colony Hybridization , Site Directed Mutagenesis , DNA and RNA Purification , DNA Sequencing and Analysis , Plasmid Cloning , Bacterial Transformations .. Technologies :",antibodies;biologics;small molecules;expression;interaction;screening
"Scientist Group Leader . . Lead a growing team at the Amgen Thousand Oaks site to determine macromolecular structures and provide structural insights into the development of innovative therapeutics . Amgen Cryo EM administrator and superuser ; oversee the Amgen Krios and Glacios microscopes operation , Cryo EM computing data storage platforms , and Cryo EM user training . A proven protein biochemist and structural biologist with 10 years of experience in biochemistry , X ray crystallography , and 7 years of hands on experience in Cryo EM , both single particle analysis and Cryo ET . Self motivated , humble , and highly productive with a strong publication record nine 1st author papers in high profile journals ; more than 20 high impact papers in total .. Technologies : Xray;CryoEM",proteins;structure
"Co Founder Managing Director at ATEM Structural Discovery . ATEM Structural Discovery provides innovative cryo EM solutions to pharmaceutical and biotechnological industries . We support the most challenging discovery and quality control efforts and allows the structural elucidation of previously unfeasible drug targets . . Delivering solutions that leverage the power of next gen cryo EM structure based drug design . Success : delivering software enabled solutions in fast paced enterprise markets Vision : To ensure ATEM is recognised as a leading provider of cryo EM structural determination services . Service : Tailor solutions using ATEM s high resolution cryo EM platform to accelerate successful drug development pipelines for the pharmaceutical industry . As a Managing Director of ATEM , my goal is to provide strategies to the pharmaceutical biotechnological companies to fast track their rational drug design projects . We do this by providing the highest resolution 3D model of even the most challenging drug targets under the fastest turnaround time . ATEM is at the forefront of the cryo EM revolution in structural biology . Our unique and completely integrated platform incorporates cryo EM optimised biochemical processes with high end data acquisition hardware and data processing augmented by continuous machine learning enhancements . Our next gen proprietary software suite allows us to deliver more detailed , high resolution 3D structural models with higher accuracy and faster turnaround times . To find out more about ATEM , visit our website at : www.atem.bio or contact me at daniel.winkler atem.bio . Technologies : CryoEM",characterization;structure
"RA Scientist . . I am a Biologist with a PhD degree in Health and Medical Sciences . In various university positions , I have been working with cell biology and biochemistry in topics related to oncology , toxicology , and neurodegeneration . My published research include investigations of teratogens and other toxins , drugs with anti cancer and memory preserving properties , and the design , and characterization of biologically active synthetic peptides . After leaving the university , I have been working with medical devices . In CooperSurgical I have been working with medical devices for in vitro fertilization IVF treatment ; primarily various media for storage , handling , and culture of gametes and embryos . As a Regulatory Affairs Officer I have been working with registrations in the EU CE marking , Australia TGA , USA FDA , and China NMPA . More recently , as a Senior Scientist , my work includes the preparation of various technical documents supporting registrations in China , and the preparation and update of biological evaluation reports , biological risk documentation , and design history documentation for registrations in the EU under the Medical Device Regulation MDR . CURRENT POSITION Senior Scientist at Technical Operations , Life Sciences , CooperSurgical Inc. CONTACT 45 2614 6036 or pswalmod hotmail.com . Technologies : Xray;SPR;CD;NMR",
"Electron Microscopy Research Core Lead Research Scientist IV . Lead research scientist , team supervisor , grad student post doc mentor , and primary contact for projects involving electron microscopy at the University of Washington Institute for Protein Design . Research focus involves the structural electron microscopy and biophysical biolayer interferometry characterization of novel de novo protein nano materials , next generation vaccines , and antibody antigen interactions . Professional focuses involve the development and implementation of a high throughput training pipeline and workflow at an institution of 100 researchers requiring electron microscopy data collection , computational processing , and interpretation . . I am a lead research scientist with extensive experience in cryo electron microscopy , biolayer interferometry , and glycoproteomics . My PhD research focused on the structural , biochemical , and biophysical characterization of antibody antigen interactions , ion channels , and various other membrane proteins . At the Institute for Protein Design , I am currently the Electron Microscopy Core Leader , where I lead and supervise a team focused on the development and implementation of a high throughput electron microscopy research pipeline . My team is also heavily involved in high resolution characterization of next generation protein nano materials , protein based therapeutics , computationally designed nano particle vaccines , and epitope mapping of antibody antigen protein complexes .. Technologies : CryoEM;BLI",antibodies;proteins;characterization;interaction;structure
"Senior Bioinformatics Data Engineer . Led , designed , and constructed internal data request system and analytical visualization tools to serve multiple departments Led , designed and developed MySQL database , docker , and API to consolidate project data from multiple departments , and setup periodic updates from files to database . . Experienced bioinformatician with 10 years working experience in Data Engineer BI Analyst with interest in application development using database , server side , and client side visualization to bridge bioinformaticians , biologists , geneticists , engineers , and various teams , to increase company wide productivity and efficiency . A self starter , fast learner , detail oriented , strong problem solver using automation platform with a combination of bioinformatics tools , scripts , and R Shiny Apps .. Technologies :",
"Postdoctoral Researcher . . Structural biologist with experience in drug discovery projects Expert in cloning , protein expression and purification biochemical and biophysical characterization structure determination using X ray crystallography and cryo EM Interpersonal skills : Experience in managing students capacity to build alliances outstanding coaching skills excellent written and verbal communication skills . Collaboration in A ParaDDisE Anti Parasitic Drug Discovery in Epigenetics consortium a European commission s funded project X ray crystallography : Enormous experience in solving structures using X ray crystallography expert in crystallization , soaking , on site data collection and structure determination . Technologies : Xray;CryoEM",proteins;characterization;expression;structure
"Bioinformatics Analyst Engineer . . My principal research interests lie in the systems biology modeling of metabolic and cellular signaling pathways , particularly bottom up biophysical approaches using statistical mechanics and non equilibrium thermodynamics , as well as integration of various transcriptomics , proteomics , metabolomics , and fluxomics datasets via machine learning to improve model predictive abilities . Other interests include genome assembly and annotations , genome scale network modeling , bioinformatics algorithm development and software engineering of integrative system biology tools . . Technologies :",
"Expert Scientist Project Chemistry Team Leader . . Current responsibilities : Project medicinal chemistry team leader . Key strengths : . More than 20 years experience as research medicinal chemist team leader , covering all stages of drug discovery on a wide array of biochemical target types and mechanisms : enzymes Bace1 , COMT , ATX , ion channels NMDA , GPCRs Orexin , Vasopressin , M1 , transporters GlyT1 , splicing modifier SMN2 addressing high unmet disorders . Strong drug hunting skills : direct or indirect contribution to the discovery of 8 clinical molecules including Bitopertin reached PhIII , GlyT1 inh . for Schizophrenia , Risdiplam in PhIII , SMN2 splicing modifier for SMA , Balovaptan in PhIII , V1a antagonist for autism , recognized by the 2017 Swiss Chemical Society , Senior Industrial Investigator Award . Successfull experience in the discovery of PET ligands for CNS targets : Discovery of 11C RO5013853 , . validated PET tracer for GlyT1 . . Strong experience in running external research collaboration projects . Passions : multi dimensional optimization , driving projects forwards together with multidisciplinary research teams , coaching junior scientists and project leaders . 73 published patent applications . 48 publications 18 as corresponding author . 15 invited lectures at major medicinal chemistry conferences . Technologies :",proteins;small molecules;screening
"Scientific Advisor . At LIPOSOMA research we manufacture and provide liposomal formulations , specifically clodronate liposomes , control empty liposomes and fluorescent liposomes . Our team of specialists and support staff has successfully served thousands of research groups worldwide . www . LiposomaTechnology . com , www . liposoma . org . Since the early seventies , Nico van Rooijen has been involved in studies on the role of various lymphoid and non lymphoid cells in the induction of ' in situ ' immune reactions against different types of antigen in the spleen . Given the idea that new scientific developments are often preceded by new technology , it was decided to develop new techniques , if answering of the main questions in this research project was hindered by the absence of suitable methodology . So , double radioisotope autoradiography techniques were developed for the simultaneous detection of various lymphoid cells and antigens . A double immuno enzyme technique was developed that allowed the in situ localisation of specific antibody forming cells in combination with their further characterisation . The ' Liposome mediated macrophage suicide approach ' has been developed to reveal macrophage functions and is now widely used for studying the many roles of these multifunctional and evolutionary ancient cells . For publications , see . the Google scholar account of Nico van Rooijen . You tube : https : youtube . com c Clodronate . Technologies :",carriers;formulation
"Principal Scientist . Here at AstraZeneca I currently have a very cool job : I find and implement new ways to engineer novel nanomedicines . Nanomedicines are important because they will allow us to treat previously undruggable diseases , cure diseases and create medicines such as vaccines more quickly . I work at the interface between cell biology and nanotechnology , using high throughput screening , automated rapid prototyping , robotic microscopy and artificial intelligence . I also lead platform and capability initiatives within image based cytometry and intracellular delivery and participate in many collaborative efforts , both internally and externally . Happily , this also includes supervision of projects up to the post doc level . . Hi Welcome to my LinkedIn profile I am an enthusiastic , innovative and passionate scientist with broad and extensive experience from industry and academia . I have worked with many different pathologies including asthma , neurodegeneration and pain , heart failure , diabetes and metabolic syndromes and , chronic kidney disease . Naturally this has included work with many target classes and techniques , but my focus is currently on cell biology and robotic microscopy in the context of nanomedicine engineering please see more below . Specialties : Image analysis cytometic and histological , multivariate statistics , high content screening , automation , assay development and technologies , target validation , regenerative medicine , neurobiology , inflammation , bioactive lipids , metabolism , Alzheimer 's , pain , GPCRs and receptor biology , enzymology and enzymes , ion channels , antibodies . . Technologies :",antibodies;idps;membrane proteins;proteins;engineering
"Researcher PHD Student . Currently investigating substrate selectivity and protein protein interactions concerning the mammalian family of SLC26 membrane transporter under the supervision of Raimund Dutzler . . I have graduated from the University of Nottingham with a first class MSci degree in Neuroscience , during which I completed a one year studentship with the biotechnology company Heptares Therapeutics that specialise in structure based drug discovery . I am currently undertaking my PhD at UZH under the supervision of Professor Raimund Dutzler within the Biomolecular Structure and Mechanism group . During my PhD I have become learned wide range of techniques in both soluble and membrane protein biochemistry . Furthermore I have advanced my skills in alternative areas , such as molecular biology and assay development techniques in order to better understand membrane transport processes . I also have gained experience in processing Cryo EM data for structural determination of challenging membrane proteins . Outside of my research , I teach regularly to groups of 10 15 students in practical classes to aid their understanding of key scientific concepts . Additionally , I have also supervised masters students undertaking research alongside my day to day tasks .. Technologies : CryoEM",membrane proteins;proteins;small molecules;interaction
"Sr Scientist . DNA encoded Library selection Target selection . Enthusiastic and self motivated researcher with 10 years of experience in managing multiple scientific projects using strong analytical and problem solving skills . Excellent communication skill demonstrated by 10 publications in peer reviewed journals , 9 conferences and 8 invited talks . Advance level biochemical and membrane protein biochemistry skills along with experience in Cryo Electron Microscopy , single particle reconstruction resulted in high resolution structure of a challenging immature ribosomal particles , helped our group in securing 1.3 million funding in the form of R01 grant . Excellent interpersonal and leadership skill developed by interdisciplinary collaborations across 3 different countries , worked closely with 5 cross functional experts .. Technologies : CryoEM",membrane proteins;small molecules;interaction;structure
"Research Fellow . . Physics PhD with 8 years experience creating mathematical and computational models of various biophysical systems using differential equations and Monte Carlo simulations . Strong analytical skills : Extensive experience performing Bayesian statistical analysis , programming in MATLAB 9 years , Python , Mathematica . Strong verbal and written communication skills : Extensive experience teaching courses to scientists and non scientists and explaining modeling concepts findings to teams of biologists . Wrote research manuscripts . Designed and taught high school and college science curricula , tying in current research and the scientific method , amazing experiments and jokes . Technologies :",
"Clinical Bioinformatics Director . Biomarker discovery , extended indication , and patient selection related to Niraparib PARP Inhibitor Characterization of NGS based genomic signatures for homologous recombination deficiency HRD and DNA damage response and CDx development Machine learning based expression subtype and clustering and immune profiling , and its application to a biomarker discovery and a single sample subtype classifier predictive for clinical response Leader in the pre conference workshop of PARP and DDR inhibitors summit 2020 Title Computational Techniques for DDR Therapeutic Development . Scientific professional with comprehensive research and project experiences in cancer genome analysis and industrial experience in drug development . Expert in computational and statistical analysis and data mining of next gen sequencing data . . Technologies :",
PHD . Solving membrane protein structure using Cryo EM . . Technologies : CryoEM,membrane proteins;structure
". . Researcher in computational biophysics . Interest in simulations of membranes , membrane proteins , ion channels . Specialties : Molecular modeling , statistical modeling , structure function relationship . Technologies :",
"Principal Scientist . Creating genetic tools for the research and diagnostics markets . . Bioinformatics and Computational biology Phd with extensive background in genomics , algorithm development , data analysis and software development . Proven ability to create and implement novel methods for genome interpretation , spanning multiple genomic assays and next generation sequencing methods . Experience working with diverse research teams and engaging in cross functional collaborations with engineering , marketing , business development and product teams . . Technologies :",
Senior Scientist . . I 'm a leading computational methods developer in cryo electron microscopy and in situ structural biology .. Technologies : CryoEM,
"Postdoctoral Researcher . After finishing my PhD , I am working at Max Planck institute for Multidisciplinary sciences as a Postdoctoral Researcher on High Resolution structure determination of Protein using X ray Crystallography technique . I am also involved in the development of techniques and technology for this high resolution data acquisition . My curiosity is pushing me to understand how much information can be extracted from Protein structures at high resolution and how much information is correct without bias . . . Technologies : Xray;CryoEM",
"Sr BioAnalytical Scientist . Management and troubleshooting of pre clinincal and clinical PK and immunogenicity assays and of bio assays related to CMC for the development of Antibody Drug Conjugates ADCs . 1988 2002 : Experience in Cell Biology and Immunology areas , both fundamental and applied , as PhD Postdoc . . 2002 2005 : Experience in and scientifically responsible for two human antibody programs in industry as Scientist at Genmab . . 2004 2009 : Responsible for the development , qualification and transfers to CMOs CROs of all CMC related binding and potency assays and all pre clinical related PK and immunogenicity assays related to antibody programs . 2010 present : Responsible for the development , qualification and transfers to CMOs CROs of CMC related molecular and biological assays related to antibody and vaccine programs . . Technologies :",antibodies;developing;stability
"Senior Principal Scientist . Process development and structural characterization of polysaccharide , proteins , glycoconjugate and other bio molecules . . Researcher with experience in process development for clinical drug manufacturing : Antibody drug conjugates Oncology , glyco protein conjugates Vaccines and Nanoparticles . Managed and contributed to structural biology and protein chemistry projects , including drug development . Expertise in protein chemistry , molecular biology , small molecule fragment based screening , and protein purification downstream and characterization . Six years of research experience in polymer organic chemistry . Expertise in process development using NMR spectroscopy as analytical tool . Key contributor to synthesis and structure function studies of macromolecules such as proteins , polysaccharides protein ligand complexes , peptides , drug screening and polymers using NMR Spectroscopy , bioinformatics and other bio analytical techniques . Adept at identifying scientific problems , forming hypotheses , designing experiments , conducting scientific studies , analyzing data and communicating results . Expertise in usage and maintenance of high field NMR spectrometers equipped with cryoprobes . Able to manage and contribute to high performance teams that achieve organizational objectives . Forge strong relationships with internal external stakeholders . Published 60 peer reviewed papers , H index : 24 ; 1469 citations , many related to project accomplishments . Gifted mentor and coach . Specialties : Process development , Tech Transfer , Drug manufacturing , Bioconjugation , Structural Biology , Protein Chemistry , Nanoparticals , Polymer characterization , High Throughput small molecule screening , NMR spectroscopy . Chromatography : affinity , HIC , IEX , SEC , AUC , CD , Fluorescence Spectroscopy , SPR and BioLayer Interferrometry .. Technologies : SPR;AUC;NMR",antibodies;biologics;carriers;proteins;small molecules;characterization;developing;screening;structure
"Postdoctoral Research Fellow . . After PhD training in stem cell biology and cryo EM , I 'm moving onto the neuroscience field and working on mechanisms of mechanosensation in physiology .. Technologies : CryoEM",
Bioinformatics Scientist . . Bioinformatics researcher at Massachusetts General Hospital and the Broad Institute . Developing computational pipelines to resolve structural variants from next generation sequencing data with a focus on populations suffering from neurological developmental disorders .. Technologies :,
"Principal Scientist Translational Science , Oncology . Translational clinical biomarker lead for Nuvation 's oncology portfolio small molecules . A versatile , articulate and solutions focused translational scientist adept in defining and conceptualizing action plans , aligning diverse scientific research teams and resources to achieve project goals . A team player with excellent time management skills , high degree of motivation and multi tasking ability with substantial contributions towards multiple scientific projects and manuscripts . Accomplished cellular , molecular biologist with additional expertise in computational biology , biochemistry and functional genomics . Successful translational science experiences include biomarker strategy , biomarker assay development validation and implementation to support various phases of oncology immuno oncology clinical development and patient stratification . Successful scientific experiences include using ML mathematical modeling to deduce and validate signaling pathways , GWAS and sequencing to identify hepatic PK PD and microgravity responsive genes . Technologies :",
"Principal Investigator . . Cryo EM structural biologist , who dedicates to solve disease related protein structures down to atomic level .. Technologies : CryoEM",proteins;structure
"PhD Student . . Engaging protein chemist with excellent experimental skills spanning broadly within Protein Chemistry . I am currently looking for new projects that will allow me to unleash my passion for proteins , be it academia or industry . I am self motivated , structured and independent . I am also a devoted mother , an excellent baker of cakes and newly discovered gardening enthusiast , unsurprisingly springing from a deep appreciation of nature , both the macro and microscopic . I enjoy a good puzzle , both in private but also in my professional life . I have a long track record of working in research labs going back 12 years . I started my scientific career as a research technician inducing in me a love of the wet lab and an appreciation for traceability in my research and lab safety that has stayed with me throughout my academic endeavors . During my studies of biochemistry at University of Copenhagen and Imperial College London , I have learned that working hard in general pays off . Becoming a parent has taught me to also work smarter to accommodate the new set of priorities . Both BSc and MSc projects were carried out in the lab of Jakob Winther , resulting in a minor and a major co authorship . The projects and the following research assistant work focused on protein design , enzymology and a general application of protein structure function relationship . It gave me competences within basic molecular biology USER cloning and transformation techniques , recombinant protein expression and protein purification FPLC , SEC , refolding , precipitation techniques that I was missing from my previous job in application research . It introduced me to biophysical characterization techniques fluorescence , CD spectroscopy , calorimetry , 1D NMR , thermostability and allowed me to continue with assay development bioluminescence in vivo and ex vivo . I commenced on a PhD within structural biology , shifting to mammalian protein expression of membrane proteins . I have acquired valuable transferrable skills such as academic communication and project management . Being in a newly started lab allowed me to be involved in deciding on consumables needed for my research and establish good protocols for lab work including GLP and safety . I did also acquire a sizeable set of new specialist skills , none the least a large PhD course within Electron Microscopy EM and very good skills within Negative Stain EM and some experience with cryo EM . I am very partial to coffee and would love to get a cup if you have an interesting project for me . Technologies : CryoEM;NMR",membrane proteins;stability;structure
"Scientist . . Driven by fundamental questions in cell biology , I gained broad expertise covering areas of glycobiology , lipid protein interactions , functional studies of transmembrane proteins . In my research , I combine the innovative approaches from molecular biology , biochemistry and surface chemistry with a range of unconventional biophysical techniques . Where possible , I watch the behavior of single molecules in action using high resolution microscopy . . Technologies :",proteins;interaction
"Head Bioinformatician , Glasgow Molecular Pathology Node . . . Technologies :",
"Professor of computer science . . I am a professor of computer science at King 's College London , working in user centric data science and AI . I am also a Fellow of the British Computer Society FBCS and a former Turing Fellow . Before joining King 's in 2020 , I held positions at Southampton , Karlsruhe Institute of Technology KIT , Germany Semantic Technologies Institute STI Innsbruck , Austria . I 've contributed to more than 20 research projects , often as principal investigator or project lead . Currently I am the PI of two grants : the EPSRC funded Data Stories , which works on methods and tools to make data more engaging , and the EU funded ACTION , which develops social computing methods for participatory science communities . I authored more than 100 papers in semantic technologies , knowledge graphs , human and social computation . I was also the chair of the European and International Semantic Web Conference and of the European Data Forum , and I 'm chairing the AAAI on human computation and crowdsourcing HCOMP in 2020 .. Technologies :",
"Senior Scientist Gene Therapy Process Development . . Highly productive Gene Therapy and Biologics Process Development Scientist with experience in upstream process development , cell line development , high concentrated mAb formulation development , downstream purification , tech transfer , cGMP , and eight years of experience in genomics , molecular cell biology , and neuroscience with the strong background in pharmacology and technical proficiency . Authored several manuscripts and fellowships . Able to multitask with excellent interpersonal , collaboration and leadership skills .. Technologies :",biologics;developing
"Associate Computational Biologist . . My skills are in the area of computer science , mathematics , and physics . I 'm currently working on applying techniques from computational biology to better understand the gut microbiome . Experience in machine learning , statistics , single cell RNA sequencing , spatial transcriptomics .. Technologies :",
"Scientist . Reducing Cap Ex of the patented technology for the recovery of critical metals . I am identifying cheaper material , optimizing chemical conditions and column operations . So far , I have been able to reduce Cap Ex by 4 times . . Biotechnologist with strong background and passion for antibody research . My research tool kit include MnAb , scFv , nanobody , and artificial protein . I have expertise in phage surface display library construction , selection , characterization , production and functionalization of antibody constructs and finally their application in material science as well as cancer therapy cancer diagnostic .. Technologies :",antibodies;characterization;engineering
"Associate Principal Scientist . . Extensive theoretical and practical experience in the field of enzyme kinetics , including interaction kinetics using Surface Plasmon Resonance SPR focusing on protein small molecule interactions . Skilled in assay development optimization , data analysis and interpretation as well as visualization and presentation of interaction kinetic data . Also experienced in running FBS using SPR . Specialties : Enzyme kinetics , Interaction kinetics , Surface Plasmon Resonance , Protein Small molecule interactions , FBS , Protein expression purification . Technologies : Xray;CryoEM;SPR",molecular glues;small molecules;developing;interaction
"Lead Scientist . Lead Scientist on the Kymata Atlas , a database characterising the information processing pathways of the brain and human nervous system , maintained by the University of Cambridge and MRC Cognition and Brian Sciences Unit . . Computational neuroscientist and mathematician working on human brain mapping .. Technologies :",
"Director , Computational Biology . . Skilled in machine learning on large datasets , data visualization and software design Fluent in Python , R , Java , C , C , Perl on multiple high performance computing platforms . Technologies :",
"Research Technician . Working on time resolved cryo Electron Microscopy with microfluidics , image and data analysis . . Technologies : CryoEM",proteins;structure
Associate Computational Biologist . . . Technologies :,
"Assistant Professor . . Experienced researcher with a demonstrated history of working in the field of pharmacology and structural virology . Skilled in cryo EM , X ray crystallography , structure based drug design and lead optimization , pharmacokinetics pharmacodynamics , viral vector transfection production transduction , protein biochemistry , and enzyme kinetics .. Technologies : Xray;CryoEM",proteins;interaction;structure
"NEST project SME lead engineer . . I build tools and technologies for data scientist and machine learning researchers . Before joining Roche , I worked as a research associate at the Oxford Big Data Institute , at where my job mainly focused on malaria parasite genomes and statistical genomic researches using a lot of coalescent theory . On the side , I also worked as a research consultant at the BGI , where I was focusing on developing methods for data storage using DNA . I love programming Check out some of the open source tools at https : shajoezhu.github.io software .. Technologies :",
"Manufacturing Supervisor . . Radiologisch medewerker 5B. Biodistribution study of Somatostatin radiofarmaca , building html intranet site , rewriting and checking correctness of SOP 's for thin layer chromatography of radiofarmaca . Technician , fermentation at BioTech Operations , SDS PAGE analysis of product at QC , Pharmaceutical Development Manufacturing amp ; Sciences Active Product Ingredients Large Molecules LEIDEN , Cell culture fermentation , Tangential Flow Filtration and UF DF , Kation Anion Chromatography , Affinity Chromatography Prot A , Spectrophotometry , HPLC , Column Packing , Technology Transfer , Process Excellence , Lean Manufacturing . Specialties : MS Office , antibody fermentation and purification , Lean manufacturing . Technologies :",biologics;quality
"Kempe postdoctoral fellowship . Targeting tumor stroma interactions in 3D organoid co culture systems . This cover letter and attached resume contain my previous and most recent research and teaching activities before joining the Translational Research Centre at the Umea Universitet Sweden . I completed my PhD degree in Cancer and Genetics in 2012 at the University of Barcelona Spain and initiated my postdoctoral training at Northwestern University Chicago , U.S. where I contributed to the identification of MED12 as a novel cancer driver gene in uterine leiomyoma . After moving to UK , I gained extensive experience in drug discovery and preclinical assessment of first in class apoptotic targeted therapeutics at both Institute of Cancer Research 2014 2016 and Centre for Cancer Research and Cell Biology Queen s University of Belfast 2016 2019 . In 2020 , I joined the Hematology and Regenerative Medicine HERM at Karolinska Institutet as a senior researcher specialist to therapeutically targeting undruggable transcription factors using a proof of concept proteolysis targeting chimera PROTAC and CRISPR Cas9 models in AML cells . Most recently , I accepted a Kempe fellowship at Umea Universitet to contribute to the screening of a SciLifeLab compound library in mouse and human PDAC organoids and preclinical KPC mouse models . The most relevant results have been published in peer reviewed journals such as Cell Death and Differentiation , FEBS , Modern Pathology , or Endocrinology allowing me to achieve a successful although still modest track record in projects and publications . Besides my strong background in academia and life sciences , working within multi disciplinary research teams in close collaboration with clinicians and industry i.e. Sprint Bioscience , Domainex have triggered an increasing interest in bringing innovation even closer to my most immediate career goals with special focus in the area of next generation therapeutics and identification of novel biomarkers for early detection in precision medicine . Finally , just to express my commitment to undertake supervision and managerial responsibilities to strength my current leadership skills , and to be an active and supportive member to the team . Yours sincerely , M Espona Fiedler , PhD , FHEA . Technologies :",molecular glues;developing;screening
Senior Laboratory Tecnician . Target Discovery Automation Team Screening . . Technologies :,
"Associate Director , Lead Data Architect . . . Technologies :",
Scientific Community Engagement Manager . . Microbiome scientist with a computational background and experience communicating science to a wide variety of constituencies . Experience with public policy and science outreach . Passionate about advancing the democratization of science and equitable research .. Technologies :,
"Manager , Bioinformatics . Leading a team that finds meaning in the largest genomics datasets in the world . The bigger the better . . Technologies :",
"Senior Manager , Commercial Bioinformatics . In this multidisciplinary cross organisational role I focus on coaching and developing my team which thrives on collaboration , whilst continuing to maintain the highest level of customer success . I lead a team of scientists with diverse skill set solution architects , developers , trainers working within commercial bioinformatics division . My team provides : Second level support to internal and external customers in EMEA . bio informatics professional services and implementation of best in class bioinformatics solutions to key clients . Ecosystem strategy development management for Illumina informatics portfolio . Pre sales subject matter expert consultations as well as advanced bioinformatics training for external and internal customers . Project management for new product releases within Illumina bioinformatics product portfolio , including documentation delivery , staff allocation and readiness . Driving Commercial Bioinformatics team to comply with ISO13485 certification requirements . Key subjects of team engagement include large scale genomics projects , proof of concept studies for clinical and pharma clients , sample to answer deployments , rare and undiagnosed genetic diseases RUGD discovery , metagenomics , COVID surveillance , and other key applications of Illumina NGS technology . . I am a team leader and research scientist with over 25 years of experience in biotechnology , genomics , bioinformatics , pharmaceutical industry , evolutionary biology , and ecology . I can offer a unique mixture of skills : strong leadership skills , long experience of business and commercial work and programme management with great interest in driving any enterprise to a success backed by independent inquisitive mind of a competent scientist . Specialties Interests : scientific team management , bioinformatics , clinical scientific data management , molecular genetics , environmental marine research . Long experience of customer driven environment : client support , commercial programme management , professional services , marketing , training . Finally , I can offer three languages and a track record of excellent presentation and communication skills at international level events . . Technologies :",
"Director , High Performance Scientific Computing . Director , High Performance and Scientific Computing group responsible for delivery of Pfizer s enterprise high performance and scientific computing strategy , platforms , and services utilizing on premise and cloud computing infrastructure . . Strong technical leadership and hands on experience in architecting , designing , and implementing high performance computing systems in a life sciences biotech environment . Specialties : HPC Linux Clusters Cloud Services Hyper converged Infrastructure Storage Data Backups EMC SAN , NAS , NetWorker , Isilon Scale out NAS , DDN , GPFS , Lustre , Weka Enterprise Project Management Linux , UNIX , and Windows Systems Administration Virtualization VMware ESXi VSphere Data Center Operations Systems Integration Vendor Relations Technology Transfer . Technologies :",
"Scientist . . Masters in bioinformatics with strong background in biotechnology and biostatistics . Programming proficiency in Python , R , UNIX , AWS cloud computing . Research experience with NGS data analysis , cheminformatics and biotechnology : Proposed and developed a computational approach using python to analyze mass spectral data from non targeted analysis for detection of potential pollutants . Automated data collection from GC x GC TOF MS . Developed algorithmic and machine learning models in python to classify the spectral match . Improved the analysis time to 10 seconds for a job which took 3 months of manual effort . Demonstrated the significant impacts that microbiota from patients and staff have on the evolution of microbiome on ICU surfaces . Analysed 16S rRNA gene sequences using QIIME2 Performed quality filtering , dereplicating , and chimera filtering using the DADA2 . Performed taxonomy classification and produced alpha and beta diversity metrics . Assessed differential abundance at genus level and alpha diversity comparisons . . Technologies :",
"Postdoctoral Research Fellow . . My long term dedication to the field of structural biology endowed me to build up a deep understanding on protein structures and a profound expertise in a wide spectrum of major biophysical tools including EPR , X ray crystallography , and even cryo electron microscopy . The main theme of the projects that I have carried out throughout my research career is the structural basis of protein protein and protein ligand complex formation , which I believe can be my key strength in elucidating drug target interactions and their assessment . Furthermore , 7 years of my previous industrial experience in Korea provided me a good chance to learn an efficient way of communicating with coworkers and managing projects . As a matter of fact , I could experience a huge success in one of my projects that lead to the development of functional ingredients for a dairy product , which marked annual sales of 200 million at the opening year . As are described in my resume , the key strengths that I possess for success in this position include : Extensive experiences with a wide range of protein expression systems from bacteria to mammalian cells , and large scale purification techniques for both soluble and membrane proteins Expertise in X ray crystallography , EPR , and even in cryo EM study of membrane proteins Long term industrial experience with a history of a success in the product development of a functional dairy products Excellence in scientific communication , teamwork , and writing skills developed through the previous industrial experiences and project managements . Technologies : Xray;CryoEM",membrane proteins;proteins;expression;interaction;structure
"Senior Bioinformatics Data Scientist . . I currently work as a Senior Bioinformatics Scientist at GRAIL Inc , developing bioinformatic approaches to deliver insights for early cancer detection from targeted methylation sequencing data . Previously , I was a Computational Biologist at AncestryDNA , where I developed and applied genome scale methods to understand the genetic basis of human relevant traits . I have a strong background and working knowledge in Computational Biology , Genomics , Statistics , and Machine Learning . I am experienced at quickly learning and leveraging computational methodologies to analyze large scale data . I completed my PhD in the Joint University of Pittsburgh Carnegie Mellon PhD program in Computational Biology . I primarily worked on developing computational tools , in R and Python , based on molecular evolution to associate genotypes to phenotypes . I am interested in learning about and developing Machine Learning approaches aimed at expanding our current understanding of gene regulation . Google Scholar : https : scholar.google.com citations user B5pIfJcAAAAJ hl en Publons profile : https : publons.com researcher 1685048 raghavendran partha peer review . Technologies :",
"Director , Biophysics and Injectable Formulations . I 'm working with a great , dedicated group of scientists and lab techs , heading up a department , which has biophysics of biomolecules and formulation for injectable projects as core tasks . We have access to a wide range of state of the art biophysical instruments , including in house NMR and SAXS capabilities , and we work closely together with scientists within biology and technology internally at Novo Nordisk as well as with both industry and academic partners outside Novo Nordisk . . I 'm working with a great , dedicated group of scientists and lab techs , heading up a department , which has biophysics of biomolecules and formulation for injectable projects as core tasks . We have access to a wide range of state of the art biophysical instruments , including in house NMR and SAXS capabilities , and we work closely together with scientists within biology and technology internally at Novo Nordisk as well as with both industry and academic partners outside Novo Nordisk . On the personal level I am social , flexible , conscientious and I take a pride in delivering the best results possible within a specified time frame . I enjoy and am challenged by the many facets of people management . I work very structured and independently , I am able to keep a cool head under stress and I thrive with having a lot on my plate . I have good interpersonal skills and experience in interdisciplinary teamwork , and I have thee skills to comprehend and acquaint myself with new methods and topics quickly . I speak German B2 , English and Danish fluently , and I enjoy working in an international environment .. Technologies : NMR",biologics;developing;formulation;stability
"Director Bioinformatics . . 9 years of pharmaceutical industry experience including biomarker and genomics data analysis of clinical trials , drug target discovery , and NGS based safety liability assessment 6 years of people management experience including managing Senior Scientist Scientist Associate Scientist as direct reports , hiring five PhD level scientists , and promoting three direct reports . Currently managing a team of 10 people . Strong background in bioinformatics with in depth knowledge of genetics , genomics , and molecular biology Extensive experience in single cell genomics Proficient in computer programming including Python and R , and experienced in C C and MATLAB Expertise in next gen sequencing method development and broad experience in molecular biology , mammalian cell culture , and yeast genetics Authored multiple peer reviewed publications , two patents , two patent applications , and research grants fellowships . Technologies :",
"Senior Vice President , Research Site Head . . With over 20 years drug discovery experience my focus at Boehringer is the discovery of new breakthrough chemical therapeutics for cancer patients . Drugging highly compelling but as yet intractable oncogenes such as KRAS and other Protein Protein Interactions is a major area of my scientific focus . Pushing the boundaries of what constitutes a small molecule therapeutic such as PROTACs is a necessity when pursuing such targets and an exciting part of my work with the BI team . Our philosophy is to always obtain X Ray crystal structures of protein ligand complexes to guide and accelerate drug candidate design . Innovative software development to power in silico drug design is another area of high interest in our research efforts . Design and synthesis are intimately intertwined in drug discovery and hence synthetic organic chemistry aimed to populate novel molecular topologies which complement unprecedented protein pockets is also a key area of my scientific interest . . Technologies : Xray",molecular glues;proteins;small molecules;interaction;structure
"Pharmaceutical Technology Development PT D Graduate Associate . The Pharmaceutical Technology Development PT D Graduate Program at AstraZeneca is a two year program consisting of three 8 month placements within different departments of PT D. First placement : Analytical Automation team within Inhalation Product Development Second placement : New modalities clinical formulation team within Advanced Drug Delivery . Currently working as a Pharmaceutical Technology Development PT D Graduate Associate at AstraZeneca . Before that , I ve gained a MSc degree in Biotechnology and a BSc in Bioengineering from Chalmers University of Technology Gothenburg , Sweden . During my MSc , I ve specialized in Biomolecular Science , inflammatory research and bioinformatics . Research experience includes writing a one year MSc thesis regarding GPCR signaling and termination at the Department of Inflammation and Rheumatology at Gothenburg University . It also includes writing my Bachelor thesis on the use of CRISPR Cas9 in metabolic engineering of S. cerevisiae and an internship within mammalian cell line development at ATUM in Newark , CA .. Technologies :",
"Bioinformatics Scientist III Primer Design . to be completed later . I am highly analytical and accomplished professional offering rich experience in bioinformatics , genetics , mathematics , and programming . I have completed doctorate in Bioinformatics and Computational Biology from Iowa State University , Ames , IA . I am leveraging strong interpersonal communication skills for building and maintaining long term professional relationships with clients and stakeholders alike . I can work well under pressure in a deadline driven environment . Some of my key expertise are : Bioinformatics Analysis Research Development Ecology Computational Biology Complex Solution Development Sequencing Processing Gene Panel Design Throughout my career , I have been instrumental in developing DNA probe sets , developing NAVIFY Mutation Profiler , and creating multiple complex custom panels for numerous genomes for customers . I am experienced in collecting and analyzing NGS data to share insights with management . My meticulous approach guaranteed that routine tasks were always completed on time , whilst enabling me the flexibility to respond to any urgent or unforeseen situations that arose . Trusted by management for improving processes , minimizing product cost , launching KAPA HyperCap target enrichment probes , as well as designing bioinformatics tools and delivering concurrent fast paced projects As a tech savvy professional , I am proficient in Python , Perl , R , Unix Linux , Windows , and Macintosh .. Technologies :",
"Beamline Scientist . . I am a diverse researcher in the field of structural biology . I have a vast experience on crystallography and mass spectrometry of macromolecules and experience also on many different analytical methods HDX , TLC , NMR , DLS .. and protein production and purification . I 'm always keen to learn new methods and approaches , and broaden my knowledge in studying the structure and function of proteins . I am a great group worker and love to reflect my ideas on my coworkers , but I am also an independent researcher with her own vision . I am a dynamic leader and able to keep projects under control .. Technologies : SLS DLS;NMR",proteins;characterization;expression;structure
"Principal Scientist . Lead the Membrane Protein Group , overseeing protein production , structure , research and technology efforts related to membrane protein targets . Enable small and large molecule drug discovery by designing and generating relevant protein reagents , supporting biophysical functional assays and performing structural characterization . Develop novel technologies to improve drug discovery and accelerate structural characterization , with a focus on membrane proteins . . I apply my expertise in biochemistry , biophysics , structural biology and protein engineering to increase our scientific understanding of ligand and protein structure function relationships and enable large and small molecule drug discovery against all target classes , with a particular focus on membrane proteins . My research interests are focused on studying protein complexes at or in the membrane , with the goal to uncover the molecular mechanisms that underlie essential signaling and transport processes in health and disease . I truly enjoy the multidisciplinary and collaborative approach that is required to successfully tackle any research or discovery project in my group .. Technologies :",membrane proteins;small molecules;characterization;expression;structure
"Principal Scientist . . Email : arnabde2004 gmail.com open to consulting offers ; experienced consultant for expert networks ; please feel free to consult me directly . Conversation with Nature India : Hard work knows no boundaries http : blogs.nature.com indigenus 2014 02 away from home hard work knows no boundaries.html Inventor Drug Product Lead CMC Regulatory in multiple patents that are in advanced clinical trial Springer These s Award for ' outstanding PhD research ' nominated by Columbia University Young Investigator Award by American Peptide Symposium . Experienced scientist impactful patents and publications with mini MBA Rutgers University . Author of book : Peptide Based Drug Development Springer , foreword by Prof. Martinez Chairman , European Peptide Society Cover article EMBO Reports and Journal of Biomedical Materials Research Skills : Formulation : high concentration protein antibody ; lyophilization , small molecules , hydrogel , liposomes , oligonucleotides aptamers , nanoparticles , parenteral , sustained release ; excipient ; biophysical characterization of biologics monoclonal , bispecific antibodies , antibody drug conjugates ADCs , etc , peptide synthesis solid phase and PEGylation . Analytical : chromatography size exclusion , ion exchange , affinity , reversed phase ; LC MS , HPLC UPLC SEC , IEX , RP , HIC , SEC MALLS , DSC , DSF , ITC , DLS , zeta potential , viscosity , rheometry , injectability , UV spectroscopy , Biacore SPR , ITC , mass spectrometry . DMPK : pharmacokinetics , pharmacodynamics , i.e , PK PD ; MSD ELISA analysis , ligand binding assay , Gyrolab immunoassay , handling biological samples . Drug Delivery : Companion diagnostics , polymer ; freeze drying , transdermal , subcutaneous , microneedle technology . Protein Biochemistry : Protein expression bacterial and mammalian HEK and CHO cell lines , purification ; gel electrophoresis , SDS PAGE , western blots . Molecular Biology : Genome editing BAC based cloning , cell line engineering , transfection , mutagenesis , cell based assays , cell culture . Immunology , Inflammation and Oncology : mouse models , Flow Cytometry FACS ; immunohistochemistry , qPCR , gene expression , biomarkers .. Technologies : ITC;SLS DLS;DSC;SPR;DSF",antibodies;carriers;peptides;small molecules;characterization;formulation;screening;stability
"Analytical Chemist . . More than six years of hands on experience in Analytical Chemistry backed by Synthetic Medicinal Chemistry including establishing experimental strategies and trouble shooting experience . PhD in Synthetic Organic Chemistry from State University of New York at Buffalo , USA . MS in Protein Engineering from The Department of Chemistry and Molecular Biology from Gothenburg University , Sweden . 8 years hands on experience with challenges of Medicinal Chemistry in Lead optimization and Lead generation . Design development of multi step synthesis for natural biological and pharmaceutical materials as well as fine chemicals for over 20 years . International experience : Worked in USA and Sweden Expertise in various analytical and purification techniques including NMR , HPLC , LCMS , GC , GCMS , Karl Fischer Volumetric and Coulometric Titration , FT IR and others . Knowledge in cell culture , in vitro studies , western blot , real time qPCR , protein production , purification . Technical experience includes regular use of Microsoft Office , including Word , Excel , PowerPoint , also ChemDraw . Experience with Laboratory Information Management System LIMS , Bruker Topspin , Empower Chromatography Data System Waters , LabX. Also USPTO , Micropatent , espacenet EPO , SciFinder , Reaxys and other internal company databases . Experience with Electronic Laboratory Notebook ELN . Individual performer and team player Edited scientific publications . Technologies : NMR",
"Doctoral Researcher . A key feature of future battery generations will be their fast charging capability . Polymer based battery concepts have been increasingly discussed in recent years as an alternative technology with the potential to withstand high charge rates without compromising durability or safety . In my doctoral project , I investigate redox processes in a polymer based battery by in operando Electron Paramagnetic Resonance Spectroscopy . In addition to chemical properties , material specific properties such as the homogeneity of the redox processes during charge discharge cycles and the causes of cell degradation is also investigated . . I grew up in Northern India . After obtaining my B.Sc . Hons . Chemistry from St. Stephen 's College , University of Delhi , I moved to Bonn , Germany to complete my M.Sc . Chemistry degree from University of Bonn . In my master studies , I focused on modules which equipped me with a variety of experimental techniques . The main modules include Biophysical Chemistry , Organometallic Chemistry and Magnetic Resonance Spectroscopy . During my Master thesis , I specialized in Biological High field magnetic resonance , specifically the use of Pulsed Electron Paramagnetic Resonance to measure nanometric distances in proteins . My research interests revolve around structural studies and functional studies using magnetic resonance techniques . In my doctoral project , I am investigating redox processes in polymer batteries using Electron Paramagnetic Resonance techniques . My main focus is on Organic Radical batteries and elucidating the mechanistic features of cell degradation and stability . I intend to use the insights obtained from EPR studies to optimize Organic Radical battery setups .. Technologies :",
"Bioinformatician . . Bioinformatician with 7 years experience : I graduated from Queen s University Belfast QUB with a BSc Hons in Mathematics and Computer Science . I remained at QUB to undertake an MSc in Bioinformatics and Computational Genomics . As part of my MSc project I worked with Dr Simon McDade and developed a ChIP Seq pipeline with particular focus on analysing p53 and p63 in breast cancer . After graduating from the MSc in 2016 , I spent several years working as a bioinformatician for the Internal Products team and the Commercial Bioinformatics team at Almac Diagnostics . There I developed internal bioinformatics analysis pipelines and provided computational data analysis support for a wide range of biomarker research and customer projects . I was also the lead analyst for the implementation of gene expression signatures for Almac Diagnostics claraT software . In 2019 , I returned to Queen s University Belfast as a bioinformatician in the Genomics Core Technology Unit . Here I am responsible for the development of analysis pipelines and delivering data analysis for customer projects .. Technologies :",
"Institute Scientist . . Genomic researcher with over 12 years of diverse experience in analysis of fungal pathogens and their interactions with diverse hosts . Wide leadership expertise including of a diverse computational team and of large international multi year collaborations . Deep knowledge of sequencing technologies and analysis methods for investigating genome content using assembly and annotation , identifying genomic variation , and profiling gene expression using RNA Seq . Highly productive multi tasker with a strong history of high profile publications . Exceptionally skilled in leading analysis and interpretation of microbial genomic data and collaborating with diverse teams of biologists and computer scientists .. Technologies :",
"Professor of Computer Science and DataLab Director of Translational Data Science . . Applied Data Scientist and Manager , with experience in modeling and analyzing Software Engineering , Health Data , Genomics , and Social Networks data . Director of Translational Data Science focus on Health Data research , and Co Director of DECAL , top software engineering research lab . Expertise : Data Science , Software Engineering , Statistical Modeling , Mathematical Modeling , Algorithms , Empirical Studies , Bioinformatics Computational Biology , Complex Networks . Have published more than 110 papers , garnered 7 paper awards , two test of time awards , and have been funded by NSF , USDA , FS , AFOSR , and DOD .. Technologies :",
"Computational Biologist . . I am a computational biologist with interests in genetics , transcriptomics , and development . I have directed projects studying the functional landscape of neurons Harris et al 2021 and the developmental trajectory of hematopoiesis in preparation . I made significant contributions to a project studying maize meristem development Xu et al 2021 and published software central to all of the above projects Fisher et al 2021 . I specialize in applying traditional statistical and machine learning methods in a robust meta analytic framework . I use skills in parallel , distributed , and GPU computing to process and analyze large scale genomics data .. Technologies :",
"Principal Scientist . . Since my Ph . D 2000 in the areas of Cell and Molecular Biology at Ume University , I have worked at AstraZeneca in roles such as Principal Scientist , Team Leader , Project Leader for projects in the Lead Generation phase and Process Improvement Project Leader . These roles have helped me to develop a broad understanding of the drug discovery process as well as team dynamics . My scientific interests are cellular assays in general e.g. cell line generation , assay development and compound screening and molecular pharmacology of GPCRs in particular . On a personal level , I am dedicated person with a strong passion to deliver and a team player enjoying to collaborate with colleagues .. Technologies :",membrane proteins;small molecules;interaction;screening
"Senior Scientist I GDC . Organic synthesis : Synthesis of heterobifunctional small molecule as proteolytic targeting chimera PROTAC Late Stage Functionalization LSF and total synthesis of Natural Product . Small molecule synthesis SAR of therapeutic interest and as tool compounds MOA . Purification , analysis , characterization Author and coauthor of 3 scientific publications in international science journals . . Synthesis of heterobifunctional small molecule as proteolytic targeting chimera PROTAC Late Stage Functionalization LSF and total synthesis of Natural Product Organic synthesis of small molecule of therapeutic interest SAR and as tool compounds MOA Purification of recombinant proteins monoclonal antibodies characterization Synthesis antibody drug conjugates ADCs , human serum albumin HSA conjugates to therapeutic peptide , purification and characterization Successfully developed propriety technology as applied to site specific PEGylation enzymes and peptides , evaluation of biological activities Inventor of a chemical synthesis strategy for high complexity DNA library preparation Synthesis of non nucleoside NNI small molecules as potent inhibitors of hepatitis C polymerase Synthesis substituted adenine analogs as potent TLR7 agonists DNA , RNA synthesis , purification and characterization Author and co author of 3 international patents and 21 scientific publications Specialties : Organic chemistry , synthesis small molecules and natural product . Medicinal chemistry nucleoside analogs , antiviral immunostimulant . Antibodies proteins and peptides site specific conjugation ADC , rHSA peptide , PEGylation . Protein purification chromatography and characterization IEX , HIC , PRLP , SEC , affinity chromatography , DLS , SDS PAGE LC MS . Protein protein interaction affinity KD determination SPR . DNA , RNA , peptide synthesis . NMR , LC MS MS , SPR , DLS , HPLC IEX , RP , SEC , AKTA UNICORN . Technologies : SLS DLS;SPR;NMR",antibodies;molecular glues;peptides;proteins;characterization;interaction
"Senior Principal Scientist , IMED Respiratory , Inflammation and Autoimmunity . . Specialties : Medicinal Chemistry , PROTACs , Peptides , Inhaled delivery , Antivirals , Structure based design , Drug discovery , Management . Technologies :",molecular glues;peptides;developing
"Bioinformatician . Human Genome Project . Computational Biologist nearing 50 years of software engineering experience , the most recent fifteen years in bioinformatics . I love to work with new technology and cutting edge science . Specialties : Genome assembly , genome to genome alignments , multiple alignments , cluster computing operation , web site management , MySQL database administration . Technologies :",
"Manager , Computational Sciences . . A strong critical thinker with proven ability to effectively communicate insights from large , multivariate data sets to biological relevance . Distinct problem solving and innovative perspectives developed from over 20 years of hands on cross discipline experience in biotech research and information technology consulting . Specialties include : Genome assembly and annotation , Next Generation Sequencing NGS , transcriptomics RNA Seq , microarrays , comparative genomics and variant analysis , Big Data , machine learning neural networks , SVM , data visualization , High Performance Computing , Linux , Platform LSF , Perl , R .. Technologies :",
"SVP , Chief Science Officer . . . Technologies :",
Deep Learning Scientist . Leveraging Artificial Intelligence and Molecular Biology to create new Cancer Immunotherapies . . Machine Learning and Computational Biology Biostatistics in Dr. Mona Singh 's research group at Princeton .. Technologies :,
Senior Research Scientist . . . Technologies :,
"Biotechnology Professional , Project Manager , Adviser , Consultant in Life Sciences . LiSOS is a one man business ZZP er owned by Peter Steenbakkers . LiSOS delivers consultancy services in Operations Support and Laboratory Facility Management , especially in the fields of Biotechnology , Biology and Pharmacology research . The owner of LiSOS is also the inventor of a unique antibody technology that generates monoclonal antibodies from antigen selected B cells , using a combination of B cell culture and mini electrofusion J. Immunol . Methods 1983;163:33 40 and https : webdoc . ubn . ru . nl mono s steenbakkers p geneanfua . pdf . He can be hired for advice and support in setting up this technology as well . . Management experience : . More than 25 years supervisory experience managing up to 15 direct reports both in scientific research and in research organisation . Operations lead and staff member of several Biotechnology Departments serving up to 290 scientist . Broad experience in budget control of large departments , building management , capital investments , equipment management , purchasing of materials and equipment , and many other forms of lab support . In other words : the complete housekeeping of large scientific biotech departments . Led or participated in many complex projects including building of new lab facilities , initiating a new research site in Cambridge USA , worldwide Lab Resource Spend Synergy Team , and outsourcing of Asset Management . Led various reorganisations , renovations and removals of lab facilities . Decommissioning of MSD Research Labs in Oss and setting up new organisation for Life Science Park . Scientific experience : . More than 20 years experience in cell biology . Especially B cells , T cells and macrophages . Expert on Antibody Technology and inventor of the proprietary B cell culture mini electrofusion for the generation of hybridomas from antigen selected B cells . 16 publications in peer reviewed journals from which 7 as first author and 9 as a co author . Inventor on 4 patent applications . Specialties : . Organisation and operation of Biotechnology departments . Specialist on antibody technology . Cell biology of B cells , macrophages and T cells . Technologies :",
"Senior Scientist . . I am an experienced researcher with broad expertise in structural biology , membrane protein biochemistry and biophysics . Specialties : Membrane Protein Structure and Function multi protein complexes , ABC transporters , glycosylation enzymes Cryo Electron Microscopy Cryo EM Image Processing single particles , 2D crystals Cryo EM map interpretation and protein model building Project Management and Teamwork large interdisciplinary projects Communication Skills reports , presentations . Technologies : CryoEM",membrane proteins;characterization;structure
Project Scientist . . . Technologies :,
"Research Fellow . This BBSRC funded project involves bringing a novel piece of software to a fully fledged state . The software STR MM Synchronised Trace Recording In ImageJ and MicroManager aims to facilitate synchronous and asynchronous multi modal data acquisition for academic and industrial applications . . I am an enthusiastic individual and I feel no problem is too difficult , and I thrive on understanding complex systems . I have experience of several multidisciplinary projects involving scientific research and software engineering . Technologies :",
"Operating Manager IHC . Daily operation and management of 14 technicians and 6 academic supporters in a ISO13485 regulated environment . Upstream IPQC and performance titration of immunohistochemical IHC retail antibody products . Final QC release of IHC retail products , including Class III FDA medical devices Production , processing , and QC of control cell lines for Class III FDA medical devices Daily planning of QC tests and productions Securing and developing infrastructure that enable : o Continuous project and assignment prioritization within the team and in line with overall business strategy compliance , NPIs and production site transfer o Measurement of KPI for production on time Establish and implement Continuous Improvement culture Performance feedback , and salary conversations Securing individual development plans for employees Stakeholder management throughout the organization Site point off contact to external pharma partner . I enjoy working with people . Developing and coaching is inert to me , and I energize through the success of my employees . My leadership skills are founded on my empathic and logic personality , as well as my strong scientific background that enables me to understand the needs and problems of the organization , the department , and my personnel . By nature , I worked structured and enjoy the framework in a regulated environment . I m result oriented , a strong communicator and I have a positive mindset . I m capable of keeping the overview of highly complex tasks , structures , and requirements , and at the same time ensuring excellent collaboration and an area of trust . Trust , respect , and teamwork are pivotal values to me .. Technologies :",
"Process Development Scientist . . Highly motivated , flexible and adaptable self starter , with excellent communication skills , I have won numerous awards by competition . My latest project is a stimulating role , identifying food biomarkers in biological samples , novel metabolites , for personalised diets for health . Challenging roles such as my current role and the research project undertaken for my PhD demonstrate excellent problem solving abilities and innovation . A proven track record in vaccine development and fungal genomic and proteomic research , demonstrate technical , bioinformatics and analytical skills . Mastery of molecular methods in cloning , expression and purification of membrane proteins for immunisation of two mammals has been achieved . Systematic approach to very high level mastery of technical skills was demonstrated by development of novel LC MS MS methods as senior IT Tallaght and UM biology department expert . Interdisciplinary communication and liaison with academic and technical personnel necessitated by research project and previous roles in management and training are evidence of excellent communication , team working and team building and skills . . Technologies :",
"Associate Director Team Leader DMPK . Team leader for DMPK bioanalysis Strategic development of nucleotide therapy bioanalysis ASO , siRNA , conjugates Develop bioanalytical strategies for small molecule drugs , PROTACs , peptide protein drugs , conjugated drugs , advanced delivery systems Drug development for Rare Diseases and for cardiovascular , renal and metabolism Member of DMPK leadership team LT . . Technologies :",molecular glues;nucleic acids;developing;screening
"Senior Principal Scientist . . Broad experience in applying protein chemistry , structural biology biophysics and chemical sciences to advance drug discovery programs in the biopharmaceutical industry . Expert knowledge : Structural biology biophysics , biochemistry , biotechnology , protein ligand interaction , NMR spectroscopy , chemistry , fragment based lead discovery , hit generation and validation , protein chemistry , protein expression and purification . Strong background in oncology , infectious diseases and immunology . Proven track record in academic and industry settings . Experience in leading functional area and drug discovery teams . Action oriented and quality focused with a sense of urgency . Experience in initiating , establishing and maintaining productive cross site and external collaborations . Technologies : NMR",proteins;small molecules;expression;interaction;screening;structure
"Scientist Structural Biology . . I am a biotechnology professional with longstanding experience in protein biochemistry in both academia and industry . . My area of expertise is the recombinant production and purification of membrane and soluble proteins towards structural biology and drug discovery . I have key skills in setting up a screening and production purification platform for membrane proteins and membrane protein complexes , as well as for Nanobodies as tools in structural biology or as biologics . . I currently work in a medium scale biotech where I lead a team of research associates working in different therapeutics areas with the aim of discovering conformation sensitive nanobodies against GPCRs and GPCR G protein complexes . My main interests are currently project management and team leadership towards the discovery of biologics and the development of protein based tools to aid in SBDD . . Technologies : ITC",antibodies;biologics;membrane proteins;expression;screening;structure
"Postdoctoral Research Fellow . Identification of small molecule or affimers that inhibit the formation of insulin receptor IGF1 receptor dimers as potential treatments for type 2 diabetes . I completed my MChem in Medicinal Chemistry at Newcastle University in 2005 before moving to Leeds to do a PhD designing small molecule inhibitors of Mur Ligases as potential antibacterial agents . I then spent four years in the same group 2009 2013 working on an EU funded project identifying modulators of number of different ion channels and membrane transporter proteins . In 2015 , I moved to the Leeds Institute of Cardiovascular and Metabolic Medicine to focus on research identifying modulators of new protein protein interactions involved in diabetes and its cardiovascular complications . I currently supervise 3 PhD students and a Postdoctoral Research Associate .. Technologies :",proteins;small molecules;interaction
Senior Bioinformatics and Data Scientist . . For more details on my work and resume see : http : jhmarcus.com . Technologies :,
"Graduate Researcher . Ansu Satpathy Lab . I am a second year PhD candidate in the Genetics Department at Stanford . I develop both experimental and computational genomic methods to study immunological disorders , especially cancer . Bilingual in tech and biology , I want to bring cutting edge science to patients through biotech entrepreneurship . Let s chat vincentliu.info . Technologies :",
Statistician . . . Technologies :,
"Scientist Molecular engineering . . Graduated PhD student in Biochemistry and Biotechnology . Motivated scientist , with expertise in the field of antibody engineering and discovery and infectious disease . Technologies :",biologics;engineering
"Senior Scientist . . Field tested bioinformatics scientist driven by joyful wonder at the molecular mechanisms of life , guided by rigorous methodological training . Experienced with RNA Seq , cfDNA seq , DNA seq , mass spectrometry , ChIP Seq . Strong command of R , Perl , and C . Expertise in immuno oncology , predictive biomarkers , data visualization , network biology , chromatin , and gene regulation .. Technologies :",
"Research Fellow , ECIR Affiliate Computer Science and AI Laboratory , . . Specialties : Security : Threat and vulnerability analysis , Cyberontology mapping , Smart grid Security , Cybersecurity Policy : Nation state strategy Analysis Norms formation in Cyberspace , Artificial Intelligence Machine Learning , Knowledge Representation , Software Engineering Model Driven Architecture , Formal Methods , Semantic Interoperability in large scale data sharing , Bioinformatics Large scale data Integration in genomics and medical informatics .. Technologies :",
"Proleptic Lecturer in Animal Sensing and Biometrics . . I am a zoologist experimental psychologist whose research interests primarily concern computational approaches to applied vision and questions lying at the intersection of sensory biology , psychology , history and art . I am particularly passionate about how visual scenes can be understood using computer vision and what comparisons can be drawn with biological visual systems . Academic profile : https : camolab.com members talas CV : https : github.com laszlotalas cv . Technologies :",
"Scientist Radiopharmacy . Precirix is a clinical stage biotechnology company dedicated to improving the lives of cancer patients by developing novel targeted radiopharmaceuticals using camelid single domain antibody fragments . The company is advancing its lead product CAM H2 through a Phase I II clinical trial targeting HER2 positive tumors , while further progressing and broadening its oncology pipeline . Precirix technology platform allows for a theranostic approach , using the same molecule for patient selection imaging and therapy . At Precirix , I am part of the Chemistry , Manufacturing Control Radiochemistry team . . Professional in life sciences with a strong background in radiopharmaceutical research , recently graduated as a Doctor of Pharmaceutical Sciences from KU Leuven . In my research work , I contributed to the development of new diagnostics for cancer patients in the field of molecular imaging . . Technologies :",antibodies;developing;interaction
"Scientist . Scientist with a commercial mindset . I am an ambitious and knowledge hungry bioscientist . I enjoy working in smaller teams , preferably interdisciplinary ones where I find myself being on the top of my science game . I am not afraid of hard work or elbow grease and I thoroughly enjoy learning new stuff . In 2009 , I obtained a Masters degree 1 year in Biomedicine from Lund University , Sweden . The research for my Masters thesis was conducted at University of California San Fransisco , and was focused on G Protein coupled Receptors GPCRs , one of the most prevalent types of drug targets . This is also when I got my first experience in advanced experimental methodology . In 2015 , I gained my Ph.D. diploma Molecular Pharmacology from Lund University , Sweden . The project was focused on the characterization of a specific GPCR . I gained a lot of experience in pharmacology , receptor signaling , intracellular signaling pathways , elucidation of mechanism of actions for pharmaceuticals and preclinical drug discovery methodology . After my Ph.D. , I was working as a postdoc at Boston University , MA , USA , characterizing a novel family of proteins termed non receptor GEFs . I learned a lot about structure biology , protein biochemistry and how to do good science using yeast and bacteria . In November 2017 , ReceptorPharma was founded by me and an entrepreneurial partner with the vision of becoming a leading drug discovery company focused on targeting disease associated orphan GPCRs coupled to neurodegenerative and other diseases . My scientific background has made me a competent in vitro pharmacologist with in depth knowledge of cell biology , biochemistry , molecular biology , drug discovery , neurobiology and more . As a Ph.D. , I know what it takes to successfully drive larger projects , how to meet crucial deadlines and quickly learn new scientific methodology . I am most definitely intrinsically curious when it comes to most things science . Knowledge is power . As an entrepreneur , for three years I have been following my passion for drug discovery while expanding my know how in business development . In addition to above mentioned interests and experiences , I have a secret passion for what I could call biofungal innovation a convergence of multiple different disciplines . Waste product management and refinement , innovative building materials from renewables , novel potential routes in drug discovery , creation of functional foods and more . Fungi , are just that extremely interesting and I am personally certain they will revolutionize many industries in the coming decades .. Technologies :",membrane proteins;interaction
"Chief Research Officer . . I believe that the future of biology and medicine relies on advances in computational approaches . Data collection will become more automated and routine , paving the way for advanced analytics to add value by enabling better predictions of alternative design choices , but also suggesting which data should be collected to maximise return on investment . I have a keen interest in blending dynamical systems theory with machine learning . My recent work has included basic research into the adaptive immune system , exploring the potential for novel forms of computation using DNA instead of silicon , engineering emergent pattern formation in cellular systems using synthetic biology , and understanding trade offs in biopharmaceutical manufacturing of lentiviral vectors . Experience : I have 12 years experience working in industry based research Microsoft Research , have published over 40 peer reviewed papers and developed several open source software packages . For more details on this , please visit my website ndalchau.github.io .. Technologies :",
"Senior Research Scientist Sr . Manager Pharmaceutical Development . Research Associate II : 2005 2007 : Solutions R D group as exploratory project lead , solutions chemistry animal expertise . Research Associate III : 2007 2009 : Exploratory R D group , Project Lead , in vivo in vitro expert . Research Scienist I : 2009 2010 : Renal New Product Introduction Project Lead and Solutions CMC Technical Lead Corporate Technical Award . Research Scientist II : 2010 2011 : Renal Solutions Life Cycle Management lab management 5 direct reports . Research Scientist II Manager Pharmaceutical Development : 2011 2015 : Renal solutions product support New Product Development CMC , . lab management 18 direct reports . Job titles have been changed in accordance to recent Baxter job title allignment . Senior Research Scientist Sr . Manager Pharmaceutical Development : 2015 current : . Technical R D Lead for New Pharmaceutical Product Development CMC , . projects in . Renal Therapy Peritoneal Dialysis , Hemodialysis , CRRT , Parenteral Nutrition , Intravenous Solutions , etc . support of product on the market Sustaining Products . . Senior Research Scientist Technical R D Leader in New Product Pharmaceutical Development covering R D activities from concept to launch and post launch . Technical scientific expertise : . 1 . Vaccine development : antigen selection production , in vitro tests , infection vaccination in vivo studies . KULeuven Intervet : 2000 2005 : immunology molecular biology animal science microbiology . 2 . Parenteral Solutions Baxter : 2005 current : analytical formulation chemistry CMC early to late phase development design studies , stability studies , . regulatory strategy in vivo models tox efficiency clinical trials Patents Project R D Management . Experience in leading New Product Development projects through various phases : exploratory in vitro in vivo models , preclinical tox PK , clinical studies proof of concept , CMC solution development , submission , launch and commercial product support . Experience in people management : . 1 . Direct : . Prior : laboratory management : 18 direct reports . Prior : Tech Lead management : 3 direct reports . 2 . Indirect : . Prior : core team leader . Current : Tech R D project leader : cross functional teams per project . Specialties : . in vivo infection vaccination ; dialysis , tox in vitro cell culture , antibody binding . Analytical Bio analytical methods : chemistry HPLC , biochemistry enzymatic assays , immunology ELISA , molecular biology PCR , Sequencing . Protein production purification , blotting . CMC : Chemistry formulation ; stability studies . Project management : project leader exploratory development projects , Budget project planning , Regulatory strategy . Technical R D lead : early late phase development projects and Sustaining Product projects : technical team lead coordination , CMC , interaction with regulatory and manufacturing , different product categories : Renal Therapy Peritoneal Dialysis , CRRT , Hemodialysis , Parenteral Nutrition , Intravenous Solutions , etc . . Technologies :",antibodies;interaction;stability
"Project Scientist . Analyzing imaging data from X ray diffraction single particle imaging for use in determination of protein structure Performing large scale data simulations and post processing using world class HPC resources such as Summit 1 supercomputer in world Funded as part of the Exascale Computing Project ECP to increase data analysis throughput 1000x by 2025 Developing Python code to further expand software packages for analyzing X ray diffraction images using NumPy , SciPy , Matplotlib , and Jupyter notebooks . . Scientist with a demonstrated history of working in Computational Biology and Software Programming . Strong skills in Mathematical Modeling , Python , Matlab , and C . Strong professional with a PhD in Computer Science from University of California , Santa Barbara . Skilled in shell scripting , Git , and R .. Technologies : Xray",
"Associate Scientist . . Experienced Science Research Specialist with a demonstrated history of working in molecular biology and bioinformatics research field . Skilled in Good Laboratory Practice GLP , PCR , NGS , Microsoft Word , English , Java , C , R , and Python .. Technologies :",
"Senior Scientist . . Stefan Oliver is a creative senior scientist and educator with a special interest in the membrane fusion mechanisms of viral pathogens . Stefan uses and develops multidisciplinary approaches to delineate the molecular functions that underpin the mechanics of herpesvirus fusion . Recently he has been focused on solving near atomic resolution structures of antibody bound glycoproteins using contemporary cryo EM technologies . One of his overarching goals is to understand the complex interplay of the herpesvirus fusion complex with cellular factors at the atomic level using state of the art structural biology tools . In addition to his dedication to lab based science , Stefan is involved in community outreach supporting scientists of the future . He participates as a judge for science competitions and also lectures to high school students about STEM . He is a strong advocate for the scientific method and seeks to get the best out of his mentees at all stages of their careers , guiding high school students and postdocs through their research projects . Stefan s educational background includes a B.Sc . in Immunology and a Ph.D. in Veterinary Virology . He has spent more than 25 years in academic and biotechnology research laboratories in fields spanning immunology , pharmaceuticals , infectious diseases and structural biology . Special interests outside of his primary field of research are evolution and motorcycles . Stefan was the recipient of an American Motorcycling Association AMA Service award for providing information related to COVID 19 .. Technologies : CryoEM",antibodies;structure
"Medicinal Chemist . . Currently Director of Medicinal Chemistry at Boehringer Ingelheim with leadership role in chemistry outsourcing . Academically and practically strong medicinal chemist with wide experience of both exploratory and lead optimisation chemistry . I have delivered leads and candidates across a range of disease areas Oncology , GI , respiratory , psychiatry , neurology , cardiovascular , anti infectives and a range of protein target classes 7TM s , kinases and other enzymes and nuclear receptors . I have over 15 years of experience in the pharmaceutical industry and have managed large teams of experienced medicinal chemists . Specialties : Medicinal Chemistry , fragment based drug discovery , structure based drug design , synthetic chemistry , people management , project management , data analysis , HTS follow up , chemoinformatics , team and matrix leadership , outsourcing , computational methods , lead identification , lead optimisation , people skills , patents . Technologies :",membrane proteins;proteins;small molecules;interaction;screening;structure
"Scientist . . Biotechnologist with over 5 years of experience in academic , contract research organization Fraunhofer Gesellschaft and industry Dr. Fooke Achterrath Laboratorien GmbH . Expert in the development of recombinant proteins for in vitro diagnostic recombinant allergens and biopharmaceuticals fusion proteins , vaccine candidates , antibodies and antibody formats . Extensive knowledge in protein and antibody engineering , protein expression as well as protein characterization . Proven track record in recombinant proteins , antibody engineering , vaccine development and downstream processing DSP of different protein types . Current focus on the development of innovative downstream processing DSP strategies , implementation of design of experiments DoE approaches to accelerate process development . Development of antibodies or antibody formats for immunoassays , in vitro diagnostic or therapy . Experienced in project management . Ability to conceive project proposals and transfer R D activities to cGMP process development , I am known to efficiently identify , improve and realize complex work processes and deliver results within timelines and budget .. Technologies :",antibodies;biologics;characterization;engineering;expression
"Bioinformatician . Long term data science work on multiple biomedical projects 60 datasets for 20 different projects . Machine learning and statistics on terabyte scale datasets . Involved in entire recruitment pipeline , from designing skills test , to selecting candidates for interviews , interviewing , and final recruitment decisions . Teaching machine learning to PhD students and Postdocs at University . Mentoring junior colleagues and coached intern with weekly 1 on 1 meetings to contribute to open source software and scientific publication . Intern is now joining the group as a full time employee . Co authoring multiple scientific publications https : scholar.google.com citations hl en user Q iGdrkAAAAJ view op list works sortby pubdate . My extensive experience with large scale biomedical data science has driven my enthusiasm for effective and explainable machine learning for real world problems , enabling data driven decision making . I invest in team building from recruitment through integration : I have developed skills tests for recruitment and interviewed candidates , as well as having provided long term supervision and mentoring of junior group members . I am also passionate about education and pedagogy for machine learning and related quantitative skills . During my time in academia I have enjoyed a number of highly inter disciplinary collaborations which resulted in several peer reviewed scientific publications https : scholar.google.com citations hl en user Q iGdrkAAAAJ view op list works sortby pubdate . Furthermore , I am the author and maintainer of the ClustAssess R package https : cran.r project.org package ClustAssess , which enables high resolution evaluation of clustering results .. Technologies :",
"Scientist . Develops custom software infrastructure for emergent high throughput laboratory R D processes DNA assembly , microbial strain engineering , NGS . Interfaces with software engineers to establish requirements for Zymergen 's Exploration Discovery Department . Supports experimental design , data management , and computational analysis for genetic engineering R D efforts . Developed multidisciplinary methods lab computational to inform product ideation and establish proof of concept for future product pipeline . Developed computational pipelines for de novo transcriptomic elucidation of commercially relevant novel genes from poorly characterized organisms . Collaborated with analytical chemists to develop screening assay for a novel compound identified by computational work . Participated in client scoping with Business Development to identify the key biological technical risks in new commercial partnerships . Served as laboratory co manager during large expansion of a R D automation laboratory . . Currently leveraging over a decade of wet lab experience as a full time Python developer supporting bioinformatics and R D. Expert in computational approaches that inform experimental design and analysis . Excels at big data manipulation , including computational analysis of sequencing data HTS NGS and genomic datasets . Extensive knowledge of cell biology , including genetics , genomics , and biochemistry . Thorough understanding of molecular genetic and biochemical laboratory techniques . Motivated by dynamic and challenging learning environments . Driven by the intersection of basic research , commercial application , and science entrepreneurship .. Technologies :",
"Senior Scientist . Protein Production . My research interests include development of enzymes proteins and carbohydrates for health related and industrial applications . I have experience in heterologous protein expression : in Escherichia coli , methylotrophic yeast Pichia pastoris ; protein purification : gel filtration , ion exchange , affinity chromatography KTA , ultrafiltration Millipore ; enzymology : kinetic analysis , stability , binding interaction ; and molecular biology : protein engineering , cDNA cloning . Characterisation of carbohydrate active enzymes for industrial application as well as purification and analysis of carbohydrates and proteins using various techniques : HPAEC PAD , HPLC Dionex , MALDI TOF MS Bruker Daltonics , DSC MicroCal , SPR Biacore and TLC are the research experiences up to date . Specialties : Enzyme Protein production , purification and characterisation Carbohydrate active enzymes Enzymatic synthesis of carbohydrate . Technologies : ITC;DSC;SPR",enzymes;proteins;characterization;engineering;expression;interaction;structure
"Manager , Bioinformatics Tissue Oncology . Team leader responsible for optimization of Guardant s assays by implementing algorithms to improve calling models and pioneer novel biomarker development . Responsibilities : Provide leadership and mentorship to the algorithm development team As an individual contributor , build and improve statistical models to analyze genomic and functional genomics data generated by Guardant 's proprietary assay Guide or formulate feasibility analyses , including statistical modeling and machine learning methods Analyze large volumes of NGS data and work in conjunction with assay development scientists to plan experiments and establish optimal assay conditions Keep up with the state of the art in the field and suggest novel methods , markers , and approaches to therapeutic selection Keep detailed , reproducible documentation of analysis , methods , and version controlled code Present results of your work to the broader organization . Highly accomplished principal bioinformatics scientist focused on the identification of new targets and biomarkers in cancer and age related diseases . Analyzed and examined complex data and evaluated the statistical methods and procedures used to obtain data in order to ensure validity , applicability , efficiency , and accuracy . Excels at Next Generation Sequencing NGS data analysis and the assessment of transcriptome profiling using open source software . Experience in developing and implementing pipelines for the processing of high throughput sequencing data . Created reusable macros and developed R Programs for Data Cleaning , Validation and Analysis and Report generation . Analyzed and examined complex data and evaluated the statistical methods and procedures used to obtain data in order to ensure validity , applicability , efficiency , and accuracy . Familiar with repositories of analysis tools and genomic data sets such as Bioconductor , Genomatix , UCSC Genome Browser , cbioportal , TCGA and NCBI databases . Proficient in working in a UNIX LINUX environment . 4 years of project management experience across product value chain . Experiences include strategy formation implementation , project management , market research , customer etc . Strong analytical skills and proven record in using data to derive strategy insights . Patents Galectin 3 nsSNPs : Markers for cancer . Raz , A. , Balan , V. , Nangia Makker , P. Wayne State University USSN 12 365,588 Removal of senescence associated macrophages . A. Gudkov , A. Polinsky , V. Balan , O. Chernova , B. M. Hall , P. G. Komarov , D. N. Kazyulkin , Everon Biosciences , United States patent application US 16 096,601 . 2020 Apr 23 . US2017 029372 , WO2017189553A1 Gene Discovery Isolation and identification of the new gene D NAAM . In : Balan V et al . 2008 Lifespan extension and neuronal cell protection by Drosophila nicotinamidase . JBC 238 41 : p. 27810 27819 . Technologies :",
"Senior Research Scientist . Responsible for assay development and validation to support lead optimization efforts and mechanistic evaluation of lead molecules Responsible for key cell line generation and paired isogenic CRISPR knockout cell line generation used to support pipeline program campaign . Developed and optimized both MSD UPLEX and one step luciferase reporter platforms for routine use in compound screening . These enhanced assays greatly improved throughput efficiency in assessing on target activity and driving SAR efforts around selectivity . . Passionate and highly versatile senior biologist with 14 years preclinical in vivo pharmacology and molecular biology experience in small molecule drug discovery research . Very strong interpersonal , organizational , communication skills resulting in successful and productive multi matrix relationships . Proven track record in continuous development and advancement of skill set . Excels in both a team setting and independently to drive performance and is flexible in adapting to changes . Open to seeking a position that pairs scientific experience , responsibility , and skill set in drug discovery with additional opportunities in clinical science and development .. Technologies :",small molecules;screening
Development Scientist . Process optimization to increase quality and efficiency standards of in vitro diagnostic and bioanalytical assays for virology and screening blood products . Knowledge with modern instruments such as Cobas 6800 8800 . . PCR and RT PCR assays for IVD . Protein extraction and purification . Experience in HPLC . Chromatography . Antibody screening ELISA . Flow Cytometry . MACS sorting . DNA RNA extraction and purification . Experience with mammalian cell culture . . Technologies :,
"Postdoctoral Researcher . Wrote the VISFD 3D image processing template library C 11 for detecting features in Cryo EM images solving the 3D insidedness computer vision problem . Compared these features with coarse grained simulations of viruses and bacteria . This is a continuing collaboration with my previous lab . . I write general software to simulate the machinery of the cell and active matter . I also develop software to interpret 3D data from microscopy experiments which I compare with my simulations . Publicly available programs I have written include MOLTEMPLATE moltemplate.org , MINRMS structural bioinformatics , VISFD volumetric image processing , and the molecular cellular automata extensions for the LAMMPS molecular dynamics simulation engine lammps.sandia.gov .. Technologies : CryoEM",
"Head of Unit Simulation and Learning Technology . . Mindset : To make the impossible possible By using an open and innovative mindset and with a basic believe in skilled people values it s easy to create , mature and facilitate new ideas . Experienced and profound leader and life science manager : 3 years in the Danish Healthcare System , 15 years in Diabetes Research in the Pharmaceutical Industry and 2 years in Biotech . MSc in Biotechnology Part of the Human Genome Project , PhD within G protein coupled receptor pharmacology . 10 years within leadership , people management , innovation and strategy including : change management , communication strategies , organizational structuring , innovation mindset , new idea generation processes and educational environments Lot of research and development experiences from academia , industry and public institutions I am fascinated on how leadership and good communication can engage and develop people , teams and organizations into new directions . My motivation is clearly to make synergy between people , to find new and better solutions and to make a difference for people and society .. Technologies :",
"Senior Scientist . . Self motivated scientist with experience in elucidating late phase Hematology and Oncology drug mechanism , helping to develop rational drug combination , generating reliable data that aids clinical trials , and understanding disease pathogenesis . I am a charismatic presenter with a strong experience in written and verbal communication that educates key stake holders , colleagues , and students . My previous experiences demonstrate a strong ability to drive progress and create a sturdy support for my team . Technical Expertise : Cell culture insect , mammalian and bacteria , co culture , Protein expression , purification and characterization , vector designs , cellular transfection infection , PCR , cellular assays , WB , chromatography : IEX , AE , HPLC , FPLC AKTA , radio active assays , ELISA , primary cell culture , capillary electrophoresis , lentivirus production , and more . Scientist Communicator Innovator Team player I will love to share more with you , let 's connect E mail : malapa03 gmail.com . Technologies :",carriers;proteins;characterization;expression;screening
"Cheminformatics Scientist . . Extensive background in deep machine learning and computational chemistry biophysics with degrees in both Chemistry and Computer Science 2 years of experience in a startup developing and training deep generative models for small molecule and feature optimization Applied machine learning with computational experimental data for binding affinity prediction Various skill sets in molecular featurization , characterization , clustering Expertise in various free energy calculations for binding enzymatic catalysis free energy calculation Competence to utilize skills such as cloud parallel computing acquired in real scientific projects . Technologies :",
"Process Engineer GMP Operations . Since completing my postdoctoral project in June 2019 , I took some time off to travel across Asia , where I reconnected with my Indonesian roots and visited its many islands . I have made a point to keep up with the newest trends and technologies in the protein science field , while actively searching for opportunities where I can apply my background in membrane protein biochemistry to the biopharmaceutical industry . Currently , I m pursuing a German language course . . I am energized by challenges in membrane protein biochemistry that offer opportunities to understand the vital functions that proteins play in allowing living beings to survive . AREAS I EXCEL IN . For the last 10 years , I have worked on the frontier of structural biology and proteomics . I have shed light on new classes of membrane proteins , using structural biolog , and biophysical techniques to elucidate 3 D protein structure and characterize functionality . Drawing on my PhD in biochemistry , I have developed innovative systems , and protocols that optimized recombinant protein production , expression , and purification , and enabled structural determination and functional characterization of new classes of membrane proteins with high translational applicability in pharmaceuticals and medical research . My achievements have been documented in 4 publications , many of which have gained high visibility in the protein science field . MY ADDED VALUE . Having worked in international environments for a global Fortune 500 pharmaceutical company and 2 world ranked universities , I often receive feedback that my diverse knowledge of structural biology and biochemistry is one of my greatest assets . I take a conscientious and organized approach to maintain both high quality and quantity of meaningful data . I have also distinguished myself as a leader and valued team contributor , and enjoy working with and exchanging ideas with interdisciplinary scientific teams to drive momentum on challenging projects . MY CAREER TARGET . Since completing my PhD and postdoctoral work , I took time to travel through Asia and reconnect with my Indonesian roots . Now , I am eager to solve complex protein biochemistry problems and support the design and production of novel molecular therapeutics and technology developments for science based biopharmaceutical industries . . Technologies :",membrane proteins;characterization;structure
"Assistant Ing nieur Biochimie Cryo EM . Etudes de prot ines intervenant dans la biogen se du ribosome . Production et purification de prot ines et complexes ribonucl iques Pr paration de grilles Cryo EM pour TITAN ou F20 Coloration n gative Acquisition d'images sur microscopes lectronique EPU . Passionn e depuis longtemps de microscopie , j'ai acquis au cours de mes exp riences professionnelles des comp tences en CRYO EM . Jeune et dynamique , j'ai quitt ma ville natale pour poursuivre mes r ves et continuer mon ascension en CRYO EM afin de contribuer aux recherches scientifiques . . Technologies : CryoEM",proteins;structure
"Researcher , Biomedical Engineering . Research on the development of COVID 19 prophylactics and early treatments in collaboration with Fractal Therapeutics , a drug development company . Engineering cyclic peptides to block the SARS CoV 2 spike protein from binding to its receptor . Experience with computational modeling , molecular docking , and molecular dynamics software including Chimera , PyMol , FTMap , Maestro , Glide , Desmond . Biomedical engineering student with research and leadership experience . Strong interest in the area of drug discovery , drug delivery , and biomaterials .. Technologies :",
"Senior Scientist . . Senior scientist at Morphic Therapeutic with extensive experience in computational biology , bioinformatics , and machine learning , including developing algorithms and statistical models , establishing scalable and efficient pipelines , and designing visualization tools for large scale biological data analysis , with specialization in single cell analysis .. Technologies :",
"Doctoral Student . Research regarding lantibiotics and their modification enzymes . Protein purification structure investigations X ray , SAXS , Cryo EM , MALS etc . protein activity and interactions . . Technologies : Xray;CryoEM",proteins;interaction;structure
"Senior Scientist , Computational Oncology . . Recent PhD graduate , using my optimization and machine learning skills to solve problems arising in cancer research . My background is in math , operations research , optimization and more recently ML . In the past few years my research has focused on models to identify the genetic causes of different drug responses in cancer patients and predicting drug response for different treatment options . . Technologies :",
"Scientist . Using in vivo Xenograft mouse model and in vitro cell based assays to develop small molecule therapeutics for the Ras Superfamily of Small GTPases screen and characterize candidate therapeutics . . Forward thinking biomedical research scientist with a strong background in molecular biology , biochemistry , cell biology , histology and in vitro assay development as well as xenograft mouse model with an excellent publication record . Highly skilled in mammalian , bacterial , insect cell and hybridoma cell culture experienced at using large scale mammalian cell culture bioreactor ; differentiation of embryonic stem ES cells , generation of MEFs and primary fibroblast cells , cell based and cell free assays , generating engineered cell lines , ELISA , Immunohistochemistry , fluorescent antibody technique . Proficient in isolation and analyzing DNA and RNA , molecular cloning , siRNA , CRISPR based gene editing technologies , AAV and lentivirus production , protein antibody expression and purification , SDS PAGE and western blot , qPCR , RT PCR , AKTA FPLC . Expert in mice and rat breeding and genotyping , dosing oral , IV , SC , IP , analysis of tumor growth , anesthesia , blood collection and dissection . Experienced in radiolabeled oligo extension DNA polymerase assay ; radio immunoassays . Creative , self motivated and passionate individual with easy integration in a multicultural environment and proven ability to meet tight deadlines by working in a fast paced work environment . I enjoy the challenges of learning and developing new experimental methods and applying these to scientific problems . I am very goal oriented and am flexible in attacking new problems . I have trained and supervised graduate students , laboratory fellows , postdocs and technicians . I am a great team player and have a strong ability to work both as an independent scientist and in a collaborative team environment .. Technologies :",carriers;expression
"Postdoctoral Researcher . characterise cellular RNA and protein complex ; 3D structural determination by cryo EM ; ribosome related study . . PhD grade expert in RNA and protein biochemistry , molecular biology and structural biology . Structural biologist in cryo electron microscopy and crystallography . Expert in protein production , protein protein and protein RNA interaction . Excellent in independent research in conjunction with collaborative work . Self driven experimental design and performance , results analysis and interpretation , combined with literatures searching . Resilient team player with good sense of accountability .. Technologies : CryoEM",nucleic acids;proteins;interaction;structure
"Computational Biology Scientist . . Expertise in high throughput data analysis in Bioinformatics . Integration of multi omics genomics , transcriptomics , proteomics . Customized data analysis and documentation . PhD in Bioinformatics from King 's College London Thesis title : Integrative Systems Biology analysis of protein interaction networks in normal haemopoietic cells and leukaemia . Postdoc in Hematological Medicine from Dana Farber Cancer Institute . Technologies :",
"Researcher . . I am an enthusiastic and interdisciplinary biomedical scientist with 15 years of experience in molecular biology , protein purification , biochemistry , and structural biology . Over the last decade , I have successfully carried out multiple projects in areas pertaining to capsid assembly , viral nanoparticle generation , and membrane transport . My core expertise lies in SAR studies using X ray crystallography , Cryo EM , and functional characterization using various biochemical and biophysical tools . I am goal oriented , curious by nature , and committed to solving challenging problems .. Technologies : Xray;CryoEM",proteins;characterization;structure
"MS applications specialist . . 15 years of experience in Proteomics and Mass Spectrometry 15 years of experience in separation techniques : UPLC , HPLC IEX , RP , HILIC and 2DE Human stem cells differentiation expertise Involved in the study of several human pathologies : obesity , cancer , anemia , thalassemia , cystic fibrosis and multiple sclerosis . Expertise in cell culture : mesenchymal stem cells , adipocytes and osteoblast . Experience in new methods developing protein DNA interaction , membrane proteins and lipids oxidation Metabolomics expertise , in particular to study lipids and lipids oxidations Demonstrated scientific productivity through 25 publications in peer reviewed journals 3 first author and 22 co author Experience in grant application writing and submission Academia teaching and supervisor experiences 3 university courses and 9 students tutored Able to run and daily maintain all Thermo MS instruments : OrbitrapFUSION , Q ExactiveHF , Q Exactive , LTQ Orbitrap Velos ETD , and Triple Quadrupole TSQ Vantage . . Technologies :",membrane proteins;nucleic acids;interaction
"Principal investigator Developing Degronomids for transcription factors at The SGC Frankfurt . We would like to develop PROTAC based strategies targeting the transcription factor FOXO , a key player triggering the development of many major age related disorders , including cancer , metabolic , and inflammatory diseases . . . Technologies :",molecular glues;developing;screening
"Application Engineer . . Applied biophysicist with a background in the study of ion channel structure using Cryo Electron Microscopy and the creation of biological mimics . Experienced at working both independently and on cross functional teams . Skilled at leading teams and finishing projects on time . Direct involvement in the development of a medical device from concept to prototype , including work on the filing of the patent .. Technologies : CryoEM",membrane proteins;structure
"Senior Principal Scientist , Computational Chemistry . . . Technologies :",
"Principal Scientist . . Computational biologist excited about analysis and interpretation of NGS data and its clinical applications . Proficient in NGS workflow pipeline including sequence alignment , SNP call and disease gene identification . Multi disciplinary background with deep understanding of biomedical science , population genetics and bioinformatics . Extensive experience with Linux UNIX systems and excellent skills in programming scripting languages . Great communication skills with people from biostatistics , software developments as well as other backgrounds . Extensive experience in managing , manipulating and analyzing large scale bioinformatics data from both internal and community sources 1000 G , UCSC etc . Familiar with current state bioinformatics pipelines workflows and statistical tools for NGS data analysis from determination of genetic variations to genetic mapping of disease susceptibility genes . Proficient in Linux UNIX , Mac OS and Windows , excellent in coding with Python , Matlab , Shell and C , experience with MYSQL database . Strong background in computational biology and biomedical sciences .. Technologies :",
Principal Scientist . . . Technologies :,
"Senior Laboratory Technician . . I graduated with a Bachelor degree with honours in Life Sciences Biomolecular Research from the Utrecht University of Applied Sciences in 2015 , and obtained my Masters degree in Molecular and Cellular Life Sciences from Utrecht University in 2017 . Soon I started working as a junior researcher , and after two years I started as junior technician for Artemis Bio Support B. V. and expanded to ICT management . I confidently started a PhD trajectory on antibody glycosylation , which unfortunately I had to discontinue due to lack of time with a part time work week . However , my interest in research has not disappeared . I am keen to decipher the molecular and regulatory mechanisms behind infection , disease and pathogen clearance and am interested in structural biology and bioinformatics . My work relies on both having oversight on the complete structure , and keeping track of finer details . I have been described as highly organized , self motivated , pro active and naturally eager to learn new things . I am self taught in computer handling and ICT , and got expert training in order to fulfil my role as ICT manager in a small business . Currently , I am involved in multiple projects as senior technician . . Technologies :",biologics;developing
Bioinformatics Scientist . . . Technologies :,
"ENRICH Fellow . Conducted internal business development for the student run consulting group made up of advanced degree candidates , help find clients companies for paid consulting . Worked 10 hrs week along with Ph.D. research . Client : J J Center for Device Innovation CDI . Conducted market sizing and evaluation for acquisition of a nerve ablation technology through research and physician interviews . Position : Project Manager , 4 person team , 8 weeks . Client : Marker Therapeutics . Developed patent and IP applications for developing new T cell therapy production methods . Drew up schematics , wrote descriptions , landscaped current IP . Position : Project Fellow , 6 weeks Client : J J CDI . Established a workflow and acquired materials for a surgery auto registration software for live surgery guidance . Position : Project Fellow , 6 weeks . 10 years of hands on laboratory experience . Interested in developing fields of biological research , specifically virology and synthetic biology , translating scientific developments into profitable business applications , and improving the health and scientific community of the Choctaw Nation of Oklahoma .. Technologies :",proteins;structure
"Senior Scientist . . I have been employed in the R D area at Novo Nordisk A S for the past 10 years , working on various peptide and antibody based projects in the areas of obesity , diabetes , hemostasis , inflammation and growth disorders . Here I have acquired in depth expertise within protein and peptide structure and interaction analyses using techniques such as SPR surface plasmon resonance , LC MS and 3D modelling . Also , I am experienced in generating humanization and germlining strategies for the design of therapeutic antibodies . During the past 6 years I have worked with Bioanalysis and LC MS MS assay development and validation for GLP studies . Keywords : Protein chemistry , SPR , Surface Plasmon Resonance , Biacore , KinExA , LC MS , ADME , quantitative LC MS MS , ELISA , Antibodies , 3D modelling , assay development , western blot , Enzymes , Biochemistry , GLP , Bioanalysis .. Technologies : SPR",antibodies;peptides;proteins;characterization;interaction
Computational Biologist . . . Technologies :,
"Senior Research Scientist . . Technology and human health have always been central focuses for my inquisitive nature . In my current position as Lead Bioinformatician for the Functional Genomics Platform OMXWare at IBM Research , I explore multi omics data for microorganisms . I use microbial genomics and the microbiome to expand our knowledge of human health , pathogenic bacteria , antimicrobial resistance , and food safety . . Technologies :",
PHD Student . . Wellcome Trust funded PhD student studying the mechanism of amyloid formation on alpha synuclein using a wide range of techniques including NMR and electron microscopy . . Technologies : NMR,idps;characterization;structure
"Doctoral Researcher . . My academic formation is in Biotechnology MSc and Pharmaceutical Science MSc . I worked for 3 years as a Research Associate in a biotech company Genmab , where I conducted research on antibody immunotherapeutics for cancer treatment . During those years my ambition was to understand better how efficient immune responses are generated and can be manipulated to fight aberrant conditions . . Currently , I am a PhD candidate in Immunology at the University of Liege and the focus of my research is the study of host virus interactions in the lung . More specifically , the aim of my project is to unravel some of the mechanisms that drive trained immunity by diverse viruses in the lung and the consequences of this innate memory in the fight of subsequent heterologous challenges . . . Technologies :",
Research Associate Genetic Bioinformatics . . I have expertise in machine learning and bioinformatics . . Technologies :,
"Senior Scientist . Discover oncogene induced vulnerabilities synthetic lethalities in the fatal pediatric glioma diffuse midline gliomas , and evaluate therapeutic efficacy of agents targeting the specific vulnerabilities . Studies to understand the mechanism of dependency , and mechanism of action and resistance to therapeutic agents . Studies evaluating replication stress induced DNA damage and genomic instability . 1 . Ph . D in Molecular , Cellular , Developmental Biology 2 . 12 years of experience in Cancer Biology Research 3 . Expertise in pre clinical in vitro and in vivo studies , therapeutic target discovery and validation 4 . Experience and expertise in omics technology , cell based assays , DNA damage response and repair pathway studies 5 . Track record of working in a highly collaborative environment 6 . Strong publication and presentation record . Technologies :",
". . Masters of Science degree in Bioinformatics having wet lab experience on microbial fuel cell technology and on the identification of extracellular membrane proteins that involving in electron transfer mechanisms NCBI and UniProt dependent screening , GO annotations , PPI construction and evolutionary tree construction by MEGA As a student of bioinformatics , have good knowledge of R and Perl scripting for biological data analysis . During the first M.Sc . project in Bangladesh , have 1 year work experience in a wet lab particularly in microbial fuel cell construction and operation , nanoparticle synthesis by this technique and its characterization and also on bacterial and fungal cell culture . Presently focusing on PhD position related to microbiology , microbial fuel cell , gene networking , evolutionary biology , bioinformatics , system biology , cell biology and environmental bioengineering .. Technologies :",
Computational Biologist . . . Technologies :,
"Senior Biomarker Assay Scientist . Develop , Validate and implement the Immunophenotyping biomarker assay using flowcytometry for clinical trials Phase I 2 3 under regulated controlled environment . Develop , Validate and test the clinical pharmacodynamics biomarker using Ligand Binding Assay Matrix : Plasma Serum Urine Phase I 2 3 under GLP GCP compliant . Subject matter expert in multiple assay platforms MSD ECL Luminex ELISA ELIA and working knowledge of Gyro lab ELISPOT Roche Cobas . Manage collaborative relationships with clinical study leads , project managers , platform representatives , and key internal and external stakeholders , to advance portfolio projects . Evaluate new technologies to streamline the workflows for continues improvement of clinical development programs . Contribute to study design from the perspective of sample collection , processing and data reporting . Lead the project in a hybrid environment to support the light speed clinical drug development programs . Implement the robust quality control checks on analytical instruments and maintain instrument operation , including sample preparation , analysis , end to end sample management and data reporting . Ensure that cross functional team receive the results within timeline or before the closeout action plan . Manage and encourage the clinical assay scientist to achieve the robust and reliable assay performance to sustain or exceed the team quality requirement . Support the data management team to streamline the data delivery with quality mindset . . A 12 years of translational research and 7 years of clinical bioanalytical assay development operational experience . Ready to accept the new challenges while ensuring all planned goals meet the leadership expectations . Subject matter expert in pharmacodynamics or disease related biomarkers assay development and method validation under GCP GLP guidelines Proof of Concept Proof of Mechanism studies . Critical team player in clinical assay operational management to support the first in human FIH phase 1 II clinical trials and advanced the program into Phase III exploratory to primary assay . Led and validated several immunoassays to support clinical study team requirements partial or full validation under FDA EMA ICH guidelines . Successfully developed in house ultrasensitive ligand binding method 40 cost reduction , validated and supported the first in human FIH phase 1 II clinical trial and advanced the program into Phase III . Strategic thinker and liaison between data management , project management , discovery team and clinical development team to support the bioanalytical assay implementation from feasibility to clinical assay validation . Experience in Clinical Bioanalytical Project Management Clinical Bioanalytical Method Development Clinical Bioanalytical Method Validation Clinical Sample Management Vendor Management Supply chain inventory management Bioanalytical Method Plan Protocol Report writing Bioanalytical Study Plan Report Writing SOPS Work instructions Test Method Development writing Quality Management Risk Based Biomarker Assay Feasibility Assessment Development Biomarker Assay Validation Biomarker assay Troubleshooting Analytical Instruments management Process Improvement methodology . Technologies :",antibodies;biologics;proteins;characterization;expression;quality;screening
"Sr . Research Associate . Sr . Research Associate in the Antibody engineering team . . Enthusiast , driven and eager to learn personality . Experienced in the fields of . biotech . molecular biology and genetics . bioinformatics . data analysis . operational co rdination and planning . coaching . Technologies :",antibodies;engineering
PhD Student . . I am a PhD candidate studying mitochondrial associated proteins using cryo electron microscopy .. Technologies : CryoEM,proteins;interaction;structure
"PhD student in Molecular and Structural Biology . Preliminary thesis title : TAC architecture in Trypanosoma brucei In my position as PhD student in the groups of Beno t Zuber and Torsten Ochsenreiter , I aim to characterize the mitochondrial DNA anchoring and segregation machinery of Trypanosoma brucei . Using cryo electron tomography and single particle cryo EM , I analyse the complex in high resolution , to gain insightes in its organization and mode of action . As trypanosomes only posess a single mitochondrion , with a single mitochondrial DNA network per cell , mitochondrial DNA inheritance is highly divergent from these processes in other well studied model organisms . The TAC is an interphase between the highly conserved , and the uniquely divergent . It is built of a set of trypanosomatid specific proteins that anchor the mitochondrial DNA network to the basal body of the flagellum . . . Technologies : CryoEM",proteins;structure
Postdoctoral Researcher . Study the functional and mechanistic aspect of effector proteins from Legionella using structural Cryo EM and cell biology based approaches . . Technologies : CryoEM,proteins;structure
"Director of Computational Biology and Data Science . Use data engineering , computational biology , and software engineering to convert a multiomic dataflux into ecosystem based diagnostics and therapies . Poop for the Cure . Industrial physicist with strong record of combining creativity and mathematical rigor in diverse areas of science and technology . Accelerates development of emerging technologies by drawing upon and connecting fields . Simplifies development , analysis , and communication of complex systems with quantitative methods that identify key parameters . Fifteen scientific publications . https : scholar.google.com citations user CxHHdokAAAAJ hl en Experience includes : Immune system dynamics High performance computing 149 ; Far from equilibrium , low number , chemical dynamics Computer architecture Biometrics Biochemical network inference Semiconductor processing Bio photonic imaging Certified welder . Technologies :",
"Associate professor , PhD . My responsibilities or tasks as an associate professor permanent faculty member have so far been : teaching pharmacology , supervision of Master and PhD students , acting as course director , Head of the teaching committee , conducting research of high quality , presenting scientific data at national and international meetings conferences , networking , publishing research results in high ranking international scientific journals , contributing to book chapters , applying for and attracting external grants , member or Fellow of prestigious international scientific societies , member of reviewer and editorial board as a courtesy to the scientific community , organizing and chairing scientific meetings and PhD defenses , member of the Committee for Research and Innovation . . I am a very driven , highly ambitious and productive researcher with innovative approach to research and teaching within the field of cardiovascular physiology and pharmacology . My goal is to become a Chief Executive Officer CEO for research and development or become a member of Executive Leadership Team at one of top 10 biotech and pharmaceutical companies worldwide . Throughout my academic career , I have been focusing on the regulation of vascular tone in health and disease diabetes type I II , stroke , hypertension , congestive heart failure , migraine and age related changes . Coronary arteries are densely innervated by sensory nerve endings containing calcitonin gene related peptide CGRP . CGRP is a potent naturally occuring 37 amino acid vasodilatory neuropeptide which is released from the perivascular sensory nerve endings in the wall of flow regulating intramural coronary arteries during hypoxia and by low pH levels in the myocardium , thus suggesting a vasodilatory role under ischemic conditions . So far , our studies demonstrate a larger CGRP receptor density in resistance arteries internal lumen diameter 200 m compared to larger conductance arteries internal lumen diameter 200 m , indicating that receptor distribution , calcium handling , ion channels and second messengers may be finely adjusted within the circulatory system , probably reflecting the physiological demands on the vascular segments . CGRP receptor consists of three components , calcitonin receptor like receptor CLR , a specific chaperone called receptor activity modifying protein 1 RAMP1 and receptor component protein RCP . A novel family of chaperone proteins , called RAMPs RAMP1 , RAMP2 and RAMP3 were identified as proteins escorting CLR to the plasma membrane to generate either CGRP when associated with RAMP1 or adrenomedullin receptors when associated with RAMP2 or RAMP3 . CLR belongs to class B of the G protein coupled receptor GPCR family and is linked to Gs protein . Our studies will shed light on the complexity of CGRP receptor pharmacology as well as its complex signaling pathway , thereby helping us understand its physiology as well as its role under different circulatory complications such as stroke , ischemia , hypertension and migraine . Techniques and specialties : Myography wire and pressurized , Electric field stimulation , Langendorff perfused heart preparation , fluorescence microscopy , stereology , measurement of intracellular calcium concentration , Investigations of G protein coupled receptor signaling pathways .. Technologies :",
"Senior Scientist . . Drug product expert with 6 years of pharmaceutical industry experience in formulation and process development of early stage and late stage drug development projects . Expertise in scale up and technology transfer , process validation , GMP production of clinical and validation batches . Involved in successful US FDA EU EMA filings of complex injectable products . Also possess knowledge and experience on analytical methods for drug product and polymer characterization . . Complex injectable formulations Microspheres , liposomes , nanoparticles , adeno viral vaccines . . Technologies :",carriers;formulation;quality
"Principal Scientist . . Providing mass spectrometry expertise to a multidisciplinary analytical team to contribute to the characterisation and analysis of therapeutic biologics : mAbs , non mAb biologics , conjugate vaccines , nitrosamines , oligonucleotides mRNA and lipid .. Technologies :",antibodies;biologics;nucleic acids;characterization
"Cryo EM Microscopist . . Marcelo Alexandre de Farias is a cryo electron microscopist cryo EM specialist . He received his PhD in Sciences in 2014 from University of Campinas . Between 2015 and 2018 he specialized in metrology , mainly on methods for determination of particle size ISO IEC 17025 and evaluation of measurement uncertainty using SEM and TEM . He has already received two awards for his scientific production and he is author co author of 31 peer reviewed papers .. Technologies : CryoEM",proteins;structure
"Senior Research Development Scientist . . Anna Spanopoulou studied Chemistry at the University of Ioannina in Greece and received her Diploma in 2010 . She received her M. Sc . from the University of Patras in Greece at 2012 . Her M. Sc . thesis concerned the synthesis of conotoxin analogues . She completed her PhD in the group of A. Kapurniotu at TUM in 2019 . Her PhD studies focused on the design , synthesis , and study of conformationally constrained peptides as amyloid inhibitors . . Technologies :",idps;peptides;developing
"Principal Scientist , Project Lead . . Expert for pharmaceutical drug discovery , high content screening and preclinical pharmaceutical research . Areas covered : advanced microscopy , high content screening HCS , automated image analysis , laboratory automation , laboratory robotics , high throughput screening HTS , advanced cell culture . Target deconvolution and target identification . Nuvisan PROTAC panel . Main indication areas covered : Oncology , Ophthalmology , Gynecological Therapies , Lung and Kidney diseases . Creative , collaborative and highly self motivated team player in academic and industry research institutions with proven track record several publications as last author , publications in Cell and Nature , several patents , covering a wide range of topics in molecular and cell biology . Several years of proven experience as project manager project leader in multi functional , multi institutional life science research projects and as open and flexible team player in international life science research projects . See e.g. https : www.photonikforschung.de projekte lebenswissenschaften projekt promebs.html . Leadership and development of direct reports and academic e.g. Master , PhD , Postdoc students . As part of the open innovation community consulted biotech and pharma companies in the field of life sciences see e.g. https : www.businesswire.com news home 20110609006465 en InnoCentive Honors 2010 Top Solvers Introduces Groundbreaking and www.innocentive.com top solvers 2010 Communication of complex science to specialists , journalists and lay audience .. Technologies :",molecular glues;screening
"Scientist . Pharmaceutical Development Biologicals Early Stage Formulation Process Development . Curious biochemist biophysicist with demonstrated expertise in protein DNA biochemistry and state of the art single molecule fluorescence methods . Problem solver with strong communication skills , who worked in interdisciplinary , dynamic , and international teams in Israel , Germany , Belgium , and the US . . Technologies :",biologics;formulation
Staff Physics . . . Technologies :,
"Bioinformatics Data Scientist . . 10 years bioinformatics experience leading and contributing to projects in sequence analysis and gene expression analysis in the biotech industry and academia . I have recently updated my skills for the Data Science field . Perl , Python , R , Unix , SQL , Genomics , Statistics , Octave , Machine Learning , Data Science , Next Generation Sequencing Analysis and Pipeline , Git , Docker , Bioconductor , AWS , Linux , Bash scripting , ggplot2 , dplyr , Gene Ontology , Algorithm Development , NGS , Statistical Analysis , datasets , data quality , sequence alignment , genome analysis , k means clustering , random forests , statistical modeling , biomarker discovery , object oriented programming . Technologies :",
"Post doctoral Researcher , European Molecular Biology Laboratory EMBL , Heidelberg , Germany . Developed protocol for expression of proteins in insect cells and in vitro reconstitution of large protein RNA complexes Currently performing cryo EM studies of protein RNA complexes involved in Drosophila dosage compensation Combining X ray crystallography , NMR , cryo EM data to gain structural insights into large protein nucleic acid complexes . Structural biologist with 12 years of experience in the field and 3.5 years of postdoctoral experience Extensive background in structural biology and biochemistry resulting in 19 publications in peer reviewed journals including 9 first author papers Expertise in X ray crystallography of protein small molecule complexes Experience with the study of protein ligand interaction using NMR approaches Experience with structure based small molecule design and NMR based fragment screening Comprehensive knowledge of biophysical techniques for protein ligand studies including ITC , SPR , thermoflour , MST , CD spectroscopy and FP assays . Experience with cryo EM of protein RNA complexes Extensive communication , teamwork and scientific writing skills developed through collaborations , conference talks , bench and teaching duties . Technologies : Xray;CryoEM;ITC;SPR;MST;NMR;FP",nucleic acids;proteins;small molecules;interaction;structure
"Head of Computational Biology . I lead a world class team of computational biologists , software engineers , and statisticians to discover new drugs for neurodegenerative diseases , including ALS , Parkinson 's , and Alzheimer 's Disease . Our team develops algorithms and software that integrates multiple types of genomic , transcriptomic , and phenotypic data in order to reveal molecular mechanisms that cause disease pathology . We computationally predict small molecules and gene perturbations that can therapeutically reverse these mechanisms ; we test our predictions in living models , including human cell cultures and rodent models . . I lead a world class team of computational biologists to discover new drugs for neurodegenerative diseases , including ALS and Parkinson 's Disease . My work combines a wide range of methods , including genomics , systems biology , machine learning , and supercomputing . I am also a full stack web developer . I have twenty years experience software engineering with a wide range of programming languages . I am equally comfortable engineering server side engines , scalable databases , and user centric web interfaces . Depending on the day and project , I am a scientist , leader , software engineer , big data analyst , teacher , and team player . Please message me for my recent CV and publication record .. Technologies :",
"Senior Machine Learning Researcher , Artificial Intelligence Products Group , Intel Corporation . . I am an AI research scientist and technical leader with over a decade s worth of expertise in building , analyzing , and accelerating large scale machine learning models and their hardware implementations . In addition to making extensive contributions to machine learning frameworks within startups and large companies , I also led data science engagements in the automotive and agricultural sectors . I am involved in various outreach programs aimed at exposing kids from socio economically underprivileged backgrounds to robotics and hobbyist autonomous vehicles . I am an avid enthusiast of hacking electronics . Specialties : Machine learning , optimization theory , Bayesian inference , dynamical systems , and statistical physics . Technologies :",
"Director , CMC Biologics . . Extensive hands on experience within biotech covering early and late phase R D and technology transfer . Key responsible for lead candidate selection , process development and technology transfers to CMOs for GMP manufacturing of drug substance and drug product as well as biochemical analysis and characterisation of protein therapeutics including monoclonal antibodies Solid experience from with working globally in cross cultural teams through participation in numerous project teams from the US , Latin America , across Asia and within EU . I hold a M.Sc . in biochemistry and a Ph.D. degree in protein chemistry from the University of Copenhagen . Specialities include : Idea generating Extensive product and process understanding within biopharmaceuticals Process development , scale up and technology transfer Front end studies , feasibility studies and business cases Business development . Technologies :",antibodies;proteins;characterization;expression
"Science Manager . Characterization and to a smaller extent purification of enzymes for application testing in food and detergent industries . Chromatographic techniques include HIC , SEC , IMAC , HCIC , and IEC on kta Explorer systems controlled by Unicorn software . Characterization include SDS PAGE , activity assays , IEF , and interpretation of data from MS , N terminal sequencing , amino acid analysis , DLS , and DSC DSF . Co supervisor for industrial PhD student . . Protein chemist with international work experience and experience from project work related to a broad range of industries which apply biotechnological solutions . Main focus has been on protein purification by chromatographic techniques and characterization of proteins activity and stability at process relevant conditions . I enjoy working together with people with different cultural and scientific backgrounds .. Technologies : SLS DLS;DSC;DSF",enzymes;proteins;characterization;stability
"Director , Department Structural Biochemistry . . I am a structural biologist whose research focuses on understanding molecular mechanisms underlying cellular processes in the healthy and diseased organism . With my research group , I use a multi disciplinary approach , including biochemical reconstitutions , high resolution electron cryomicroscopy cryo EM , and X ray crystallography primarily to investigate the structure of macromolecular complexes that play a crucial role in cell physiology , with a particular emphasis on toxin mediated membrane permeation and membrane homeostasis . Furthermore , the aim of my group is to understand the molecular details of muscle contraction and the dynamics of the eukaryotic cytoskeleton . A detailed understanding of these processes is of great importance as they ultimately serve to develop pharmaceutical measures to combat disease .. Technologies : Xray;CryoEM",proteins;structure
"Senior Manager , Observational Research Data Analytics . . SUMMARY A decisive and science driven bioinformatics professional who efficiently blends skills in biology , computer science , and statistics to create and deliver unique algorithms , tools , and pipelines for solving problems emerging on the cutting edge of data driven biomedical research . Outcome driven and energetic innovator with a proven track record in large scale engineering , analytics , manipulation , and interpretation of high dimensional coding and non coding transcriptome data using data integration , network analysis , machine learning , pattern mining , and statistical computing . KEY QUALIFICATIONS Strong proficiency in algorithm design and data pipeline development Profound experience in software development in R and Java Excellent verbal communicator with academic teaching experience Highly experienced in collaborating with bench scientists to consolidate data analysis with experimental design Scientific track record with first , co , and senior authored articles in top tier peer reviewed scientific journals Deep expertise in generation , analysis , and modeling of complex multivariate single cell data . Technologies :",
"Research Scientist III . . PhD in biochemistry with 20 years of multidisciplinary biomedical research experience covering oncology , immunology , complement biology , innate immunity , biomarker development , immunotherapy target discovery , infectious disease , resulting in 2.2 million grant funds from government and private sector , 1 awarded patent , 1 patent application and 19 peer reviewed scientific publications . 20 years of experience in working with protein . Expertise in characterization of protein protein interactions 15 years of translational research experience . Experience and knowledge on drug development process from discovery of a target , proof of concept , patent application , to develop an immunotherapy , and to seek collaboration from industry in order to transform our discovery into a therapeutic drug . 15 years experience of complement research in the area of infectious disease . Discovery of bacterial complement inhibitors targeting C1q , C3a , C3c , C3d and C5 ; and identification of mechanism of action for each molecule . 3 years experience in preclinical drug discovery and development of complement inhibitors for treatment of complement dysregulated diseases . On a personal side , I love to experience different culture of different countries . I love travel , hike and play badminton . I have won numerous trophies in the tournament . Scientific Specialties Drug discovery experience , Immunology , Complement Biology , phagocytes , Bacteriology , Microbiology , Genetics , Molecular Biology , Cancer research , Vaccines , Antibody Therapy . Small Molecule Therapy .. Technologies :",proteins;small molecules;characterization;interaction;screening
"Associate Scientist L2 , CMC Pharmaceutical Development Technology Analytics . Analysis of the quality and stability of lead Nanobodies during pre clinical and clinical development incorporating numerous techniques including Reversed Phase , Size Exclusion and Ion exchange U HPLC chromatography , capillary electrophoresis , Dynamic Light Scattering DLS , Micro Flow Imaging MFI , Light obscuration , osmolality and viscosity measurements , endotoxin testing , Host Cell Proteins assays , Method Development . In process stability studies , stress testing and the development of stable formulations . Control the quality and consistency of Nanobody productions and thereby assist in the development of a large scale manufacturing process for a specific lead Nanobody . Physico chemical characterization of Nanobodies , identification of product variants and investigation of degradation pathways . Master in Biochemistry and Biotechnology from the University of Ghent , Ghent , Belgium with a major in Biomedical biotechnology and minor component in Structural Biochemistry . B. Sc . Honours Degree in Biochemistry , Molecular biology and Biotechnology from Dublin Institute of technology , Dublin , Ireland . . . Technologies : SLS DLS",antibodies;characterization;quality;stability
"Health Sensing Data Scientist . Developing and tuning algorithms for extracting insight from sensor data and optimizing performance across a large user base via analysis and automated learning . . I am interested in methods of acquiring and utilizing knowledge , both how this is done by living beings from cells to humans and how we might reproduce it in artificial systems . My graduate work focused on applying this line of inquiry to protein structure inference , and determining how we can utilize experimental data to its full extent . I have since worked as a data scientist building automated approaches for interpreting health data from medical records at Lumiata and from sensors at Apple . Specialties : machine learning , deep learning , computational structure prediction , data analysis . Technologies :",
"CRO Study Director . . Dick Terwel holds a Ph . D. in Medical Sciences and is an expert in animal models for Alzheimer s disease . His drive is to understand pathological mechanisms to be able to help find a cure for this devastating disease . . He developed several animal models for tauopathy and neurodegeneration at KU Leuven . In depth analysis of these models and of crosses of different transgenic mouse lines has helped to further elucidate disease mechanisms and validate the amyloid cascade hypothesis of Alzheimer s disease . Relevant aspects of Alzheimer s disease on the basis of research in mentioned models and crosses are synaptic changes , clearance of A , neuroinflammation , spreading of tau pathology , interaction between Abeta and tau pathology . The animal models and yeast based models formed the basis for spinning off reMYND . As the CRO Study Director at reMYND he is responsible for client consultation and all operational aspects of proof of concept or hypothesis testing studies . Clients include big pharma , biotech and academic groups . . Technologies :",idps;formulation
Associate Principal Scientist . Biophysics support for drug lead generation projects . Biomolecular NMR . Fragment based screening . Hit conformation and drug mode of action studies . . Technologies : NMR,small molecules;interaction;screening;structure
"Chemistry Consultant . . Experienced R D scientist , senior manager and innovator in the areas of synthetic polymers and antibody protein bioconjugation . Co founder of PolyTherics , UK now Abzena . Developed and led the science team at PolyTherics and later the Chemistry team at Abzena over 15 years . Extensive experience of managing multi disciplinary teams and projects across different locations . Part of the management team that grew PolyTherics as a successful start up from only 2 employees . Track record of innovation and commercial exploitation of scientific research . . SIGNATURE STRENGTHS . : : Development Intellectual Property Protection Of Proprietary Technologies . : : Leadership Delivery Of Multi disciplinary Projects Including Service Projects With International Collaborators . : : Scientific Leadership Innovation . : : Management Of Patent Portfolio . : : Scientific Support for Business Development . SCIENTIFIC EXPERTISE EXAMPLES . : : Polymer Synthesis Derivatisation . : : Antibody Drug Conjugates ADCs . : : PEGylation of Therapeutic Proteins and Peptides . : : Chemical Fusion of Antibodies , Proteins and Peptides . : : Protein Labelling Biotin , HRP . : : Radio Labelling . : : Organic Synthesis of Novel Conjugating Reagents . : : Novel Adhesives . : : Protein and Peptide Purification Characterisation . : : Biological Characterisation and Bioassays of Conjugates . Technologies :",antibodies;developing;engineering
"Pharmaceutical Specialist IPT Nexplanon . Ensure that pharmaceutical production within Integrated Process Team Nexplanon is performed in line with current GMP guidelines . Key activities : . Deviation management , Risk Management , Change Control , RCA analysis , Problem solving , Continous improvement , CAPA management , Document management SOP , GMP , Complaint investigation and handling . . Enthusiastic Scientist Manager with a broad expertise in antibody sciences , cell biology , molecular biology and assay development within R D in the field of immunology and oncology . In the role of Safety Officer gained a lot of experience in Environment Health Safety EHS , compliance with legislation and regulation concerning contained use of genetically modified organisms GMO and ARBO related matters . Because of my versatility , quality mindset , high adaptability and eagerness to learn , I am a suitable candidate for various pharma and biotech related functions . I have a high sense of responsibility , good organizational skills and work very accurately . I like to work in a team but am very capable of working independently . Versatile Focus on Quality Organized Accurate Eye for detail Team player Communicative . . Technologies :",
"PHD Student . Studying protein complexes involved in mRNA processing with X ray crystallography and cryo EM Group of Prof. Martin Jinek Supported by Boehringer Ingelheim Fonds Fellowship 2018 2020 . Structural biologist and biochemist with 9 years experience in basic research . Passionate about protein architecture function and solving molecular puzzles . Currently wrapping up my PhD research in the exciting field of mRNA processing . Looking for new challenges in the life sciences , diagnostic , or pharmaceutical industry .. Technologies : Xray;CryoEM",nucleic acids;proteins;interaction;structure
"Senior Field Data Scientist . . Data scientist skilled in the application of quantitative data analysis to real world problems , with a focus on biomedicine . Specialties : Computational biology and bioinformatics Analysis of high dimensional data Gene expression microarray analysis HER2 breast cancer Excellent communication and teamwork skills Conveying complex science to lay audiences . Technologies :",
"Senior Scientist . . Awarded Summa cum laude Excellent for Ph . D thesis focused on biological characterization of . small molecules . 5 years of expertise in assay development , high throughput small molecule screening and . characterization , target identification and validation . 7 years of multifunctional regulatory knowledge and a strong technical background in biological . and pharmaceutical sciences . Language proficiency : English Fluent , German B1 , Hindi and Marathi Native . Key specialties : mass spectrometry based proteomics , assay validation and execution , pre clinical drug discovery , target identification and validation , protein protein interaction , biological screening , mode of action studies , data analysis , strong interpersonal and cross cultural skills , entrepreneurial , project Management . . Technologies : Xray",proteins;small molecules;screening
"Senior Biological Data Scientist . . I am graduating with my PhD in Biomedical Informatics in August of 2021 . As a PhD level computational biologist and data scientist , I have extensive experience applying my strong technical skills to complex biological datasets . During my PhD , my research focused on examining how sex and hormones contribute to variability in gene expression and genomic data . I also am passionate about teaching and mentoring students in the sciences .. Technologies :",
"Principal scientist . Neuroscientist at H. Lundbeck A S . Experienced researcher and project manager . 8 years of industry experience . Specialist in ex vivo and in vivo models of protein aggregation , neurodegeneration and inflammation , with extensive knowledge of neurodegenerative and innate immunity pathway regulation . I have experience in grant writing , overseeing and writing applications for animal experimentation , has been involved in several large EU collaborations , both from the academic and industry side FP7 and IMI2 projects . Coordinated or contributed to several international academic research collaborations and pharmacological and diagnostic development projects involving multinational pharma companies . I am interested in a research and or supervisory position within industry allowing me to develop as a scientist and as a leader . Specialties : Leadership , strategic planning , knowledge based decision making , communication , technical writing , pharmacology , drug discovery , in vivo and ex vivo models of neurodegeneration and inflammation . Assays for monitoring protein aggregation in cells or ex vivo .. Technologies :",idps
"Principal Bioinformatician . I work on understanding pathogen detection and emergence in the microbiome , and high quality reproducible research practices for genomic surveillance . I lead the software development of the JUNO project , a genomic data tracking and data sharing platform for the global surveillance of the pathogen Streptococcus agalactiae . I develop bioinformatics pipelines and informatics training for the Bentley group and collaborators of the Global Pneumococcal Sequencing Project . My research interests have been on detection and prediction of emerging pathogens from the microbiome , with a focus on the interactions between antimicrobial resistance and mobile genetic elements in metagenomes . . Leader in bioinformatics with specialist technical expertise to build high value products and services for public health experts and epidemiologists . Committed and collaborative leader who engages with partners and stakeholders to expand genomic surveillance globally . Talented strategic thinker who applies strong , principled goals to drive effective and fair research practices .. Technologies :",
"Director Of Bioinformatics . . Bioinformatics scientist with broad experience in building Gene Regulatory Networks GRN 's and NGS such as ChIPSeq and RNASeq . Specialties : Microarray analysis , Gene Regulatory Network GRN , pathway network analysis , NGS Illumina RNA Seq ChIP Seq Analysis , mathematical modeling , Bayesian Network . SQL , Matlab , SAS , Perl scripting , BioPerl , BLAST .. Technologies :",
"Scientist Protein purification characterization Analytical Biophysical methods development . Designing , conducting and troubleshooting a diverse range of molecular biology , biochemical and biophysical experiments to study the structure and function of Hsp90 protein . Molecular Cloning , expressing and purifying Hsp90 protein from prokaryotic and eukaryotic host using fast protein liquid chromatography AKTA FPLC . Conducting biochemical analysis of Hsp90 multi protein complexes using chromatography , gel electrophoresis , western blot techniques . Characterizing Hsp90 enzyme structure and function using fluorescence microscopy , Atomic force microscopy and ATPase activity assay . Developing a custom built fluorescence microscope to visualize fluorescent dye labelled protein single molecules . Constructed and Taught seminars and practical courses for Master 's students . . I am a highly motivated protein biochemist with 10 years of expertise in process development for recombinant protein expression , purification , and characterization using chromatography , biochemical and biophysical techniques . I am an interdisciplinary scientist leading multiple projects in protein DNA characterization , formulation , protein ligand , and protein drug interaction , DNA nanoparticle drug interaction , lipid based drug delivery , and drug discovery using analytical and biophysical techniques . I have successfully led multiple projects in biochemistry , molecular biology , structural biology , and cell biology . I have a strong background in science communications and scientific grant writing as demonstrated by 15 publications , conference presentations , invited talks , and awards from funding agencies . Technical skills : Biochemistry : Protein expression protein purification size exclusion chromatography SEC ion exchange chromatography affinity chromatography FPLC HPLC gel electrophoresis SDS PAGE protein crosslinking enzyme kinetics . Molecular biology Cell biology : Cloning nucleic acid extraction and purification PCR colony PCR transformation transfection western blotting bacterial cell culture Hela cell culture virus culture and virus purification sterile technique cell culture media preparation . Biophysics : Fluorescence assays circular dichroism spectroscopy CD dynamic light scattering DLS UV vis absorption spectroscopy analytical ultracentrifugation AUC microfluidics isothermal titration calorimetry ITC FTIR Structural biology : TEM , Cryo EM sample preparation Cryo EM data processing Relion Hands on experience on NMR spectrometers Bioinformatics Data Science : Statistical data analysis Origin 8.5 Image Analysis Image quant and Image J Protein structure and sequence analysis ExPASy , PyMol Chem Draw C Linux Interpersonal skills : Problem solving and scientific creativity multitasking time management excellent written and verbal communication organized and detail oriented deadline conscious ability to handle high volume demands I am looking forward to an opportunity where I can utilize my skill sets to grow as a professional and be resourceful to my employer . I am actively seeking new roles and willing to relocate for the right opportunity . Feel free to contact for consultation , science writing related enquiries tanumoy.biochem gmail.com . Technologies : CryoEM;ITC;SLS DLS;AUC;CD;NMR;FP;FRET",proteins;small molecules;characterization;expression;formulation;interaction;structure
Senior Scientist . . Genomics and genetics scientist with extensive molecular biology expertise and a goal to harness biological information for a healthier future . Technologies :,
"Postdoctoral Researcher . Setting up and maintaining the Two Electrode Voltage Clamp with Fast solution perfusion system ; Membrane protein expression in Mammalian Cells via viral infection ; Structural analysis of purified membrane proteins via Negative Stain Electron Miucroscopy . I graduated from the Indian Institute of Technology , Kharagpur , India , with Bachelors and Masters degrees in Biotechnology and Biochemical Engineering , in 2008 . Thereafter I pursued a doctoral degree at the University of Wisconsin Madison , graduating with a Ph.D. in Biophysics in June 2014 . Since then , I have been a post doctoral researcher working at the Vollum Institute , Oregon Health and Science University , Portland , with Dr. Eric Gouaux . In my graduate research I have published 10 peer reviewed articles which have accrued more than 100 citations so far . I have received multiple awards for my research and several of my papers have received glorifying reviews commentaries published in leading international journals , press release articles , etc . More generally speaking , my graduate training polished my analytical skills and problem solving ability , while honing my presentation communication skills . I have guided several group members in their research and managed over 3 multi disciplinary research projects . While my graduate training was in electrophysiology , my postdoctoral research work employs a wide variety biochemical and structural biology techniques , such as membrane protein purification , protein ligand association studies , cryo electron microscopy , etc . I am a passionate , determined and hard working individual who loves to crack new and challenging problems and avails every opportunity to learn and implement new strategies , while constantly striving to achieve perfection .. Technologies : CryoEM",membrane proteins;expression;interaction;structure
"Staff Scientist . . I am interested in Machine Learning , AI , Data Science and Computational Biology . My research focus is Causal Inference and its application to data driven areas like Biomedical science .. Technologies :",
iNANO Cryo EM Facility Manager . . . Technologies : CryoEM,
"Quality Control Scientist I . Performs quality control testing of in vitro diagnostic polymerase chain reaction PCR Accula SARS Cov 2 test cassettes , swabs , and buffers , including stability and validation testing Completes written real time documentation during testing Complies with Good Laboratory Practices GLP and Good Data Practices GDP Understands Good Manufacturing Practices GMP Conducts Out of Specifications OOS investigations and initiates Non Conformance Material Reports NCMR Supports Deviations , Change Orders COs , and Corrective Action and Preventative Actions CAPAs Reviews testing documentation for submittal to Quality Assurance QA Proposes and implements process improvement ideas to leadership regarding document changes and lab processes resulting in fewer errors , increased efficiency , and reduced waste Supports Research and Development R D team in assay development for new product lines . Highly motivated and enthusiastic quality control scientist who excels in a fast paced , collaborative work environment .. Technologies :",biologics;quality;stability
"Lab head and Project Leader . Laboratory Head in Pharmaceutical Sciences in pharma Research and Early Development pRED . . My group works on predicting and understanding the pharmacokinetics of therapeutic antibodies by developing novel cellular assays and analysis methods . . As DMPK PD project leader I 'm providing scientific and strategic leadership in project teams with a focus on large molecules . Here I aid in the selection and timely development of new drug candidates through close interaction with therapeutic areas and affiliated non clinical , clinical and regulatory functions . . Extensive background in DMPK of therapeutic antibodies , biochemistry and biophysics of antibodies and membrane proteins with highly developed skills in project management and assay development . Expert in protein engineering , large molecule pharmacokinetics and transporter studies . History of team based success , including project management and leadership roles in scientific research and consulting . Excellent written , illustrative , and verbal communication skills cultivated through scientific publications , presentations , grant writing , team based consulting , training laboratory personnel and consultants , mentoring scientists , and teaching experience . Motivated by solving complex problems , working with others to achieve project goals and learning new things . . Technologies : FRET",antibodies;membrane proteins;characterization
"Senior Scientist . CMC Drug Product Development . I am a PhD in Pharmaceutical Sciences with a broad field of experience from university , pharmaceutical industry and regulatory authorities . University research projects were undertaken in Denmark , USA and Australia . My main areas of professional experience cover Formulation and process development of oral solid dosage forms including statistical design of experiments , stability studies , specification setting , method validation and preparation of regulatory CMC documentation for clinical trials and marketing autorisation ADME in vitro and ex vivo studies of both small and large molecules , mainly focused on the enhancement of gastrointestinal drug absorption and on drug interactions due to membrane transporters Drug formulation development , GMP drug product stability and CMC documentation of injectable peptides Assessment of clinical trial applications and safety surveillance of active trials . Technologies :",membrane proteins;formulation;stability
"Senior Lecturer in Biotechnology . . I am a passionate scientist , an entrepreneur and a mentor . I have developed an academic career that spans over 15 years , having taught in all levels primary to tertiary of education in Nigeria and mostly at the higher education level in UK . My research interest is largely in drug discovery with special interest in the development of novel anti diabetic agents from natural sources including plant species and amphibian skin secretions . My research output include several publications in reputable journals , an estate of patents and several awards such as the O Donovan Medal of the Irish Endocrine Society 2011 , Young Scientist Training Award of the European Association for the Study of Diabetes 2011 , Young Endocrinologists Trainee Award of The Society for Endocrinology 2012 , Best Poster Award at 2nd Peptide Workshop of the Irish Peptide Society and presentation to the UK 's House of Parliament . I have also generated substantial research funding . I am also committed to community outreach . This passion drove me to co found Bioscience Research Education and Advisory Centre details at www.breacnigeria.org ; a not for profit organization committed to the promotion of science education and research in Africa . Through this organization , I facilitate bioscience skill acquisition training workshops for students and scientists in Africa . I also established Cecejyde Lifesciences in August 2014 as the first Research Spin out company to facilitate research translation and capacity building in Africa . Over the past 15 years , I have occupied different positions through which I have developed capacities to mentor , support and provide pastoral care . I served previously as a Special Assistant to a Vice Chancellor , Acting Director of a research centre and Acting Head of a department , Leader of a music band , Executive Member of a national professional body and many more . . Technologies :",
"Senior Genomics Scientist . Developing methods for analyzing NGS data from CRISPR genome editing experiments including editing outcomes and off target effects . Analyzing NGS data from CRISPRi a screens and validated CRISPRi a screening libraries . Also analyzing sequencing data from ChIP Seq , RNA Seq , GUIDE Seq , AMP Seq and other sequencing experiments using novel pipelines , existing programs , and customized programs as needed . Developed a pipeline to automatically analyze editing outcomes in amplicon sequencing of hundreds of CRISPR edited samples simultaneously based on user created manifests . . . Technologies :",
"Research Scientist Associate IV . I help run the Sauer Cryo EM facility at UT Austin alongside Alex Brilot . I assist in training , help make sure the facility runs smoothly , help troubleshoot issues with the Electron Microscopes , and perform research for outside users . . My fascination with detail brought me into the field of biochemistry and continues to drive me through my PhD. I loved the level of detail of chemistry but had a greater appreciation for the stories behind biology . In my first biochemistry class at the University of Michigan , I was absolutely fascinated being able to visualize the atomic structure of chymotrypsin and the clues the structure gave about how it functions . Fast forward several years , and I m now working on the structural biology and biochemistry of type I CRISPR complexes using Cryo electron microscopy . Being able to see real images of proteins and protein complexes has cultivated my curiosity and attention to detail that I felt in my first biochemistry class . I 've also had the wonderful opportunity to present this research at various conferences and retreats , such as CRISPR 2019 in Qu bec City . I ve begun to expand my fascination for detail into other areas that I m passionate about , including science communication and mental health . My first volunteering experience was with Present Your PhD PYP , a group at UT Austin run by graduate students that does science communication and outreach for K 12 students . In a given PYP event , a graduate student presents their PhD research in a way that s digestible for younger students while encouraging engagement and curiosity from them . I ve also been a part of the Innovative Genomics Institute s Ask a Scientist program , where anyone can ask any scientific question and receive a 1 to 1 response from a scientist , either by email or zoom . This past fall , I also began to volunteer with the UT Counseling and Mental Health Center as both a student advisor to discuss mental health resource availability to graduate and undergraduate students and a student peer support group leader . My plan going forward is to graduate with my PhD in May 2022 and transition into a career of pharmaceutical research using cryo EM . I hope to utilize my skills both as a scientist and as a communicator to succeed in the biotech industry and facilitate therapeutic research through a structure based design approach . I am looking forward to learning the strategies of industry research and collaborating with other scientists who may be experts in other biochemical methods in a shared goal of developing therapeutics .. Technologies : CryoEM",proteins;structure
"Senior Scientist . . Design , synthesis and purification of complex target molecules drug like small molecules , splice modifier small molecules , peptides and PROTAC s . Med Chem lead for several early projects in the neurodevelopmental and movement disorder field . Strong problem solving ability in organic chemistry demonstrated in several CNS and oncology projects . Able to use modeling techniques independently or together with CADD expert to rationalize findings and to design new compounds . Developing of SAR for a given class to reach a decision point considering medicinal chemistry parameters for optimization . Leading a team of external co workers at a CRO . Instructor of students and Lehrmeister of apprentices . Preparation of patents and co author of publications . Effective communicator of results in oral and written form in cross functional project teams . Responsible for full compliance to all Safety Health Environment SHE regulations .. Technologies :",molecular glues;peptides;small molecules;interaction
"CIO VP of Research Infrastructure . Integrating and advancing the infrastructure of Gladstone , including all IT functions , physical facilities , and core recharge units . . A strategic builder and leader of high performing teams in high tech and biotechnology . A proven creator and promoter of innovative and people oriented company culture .. Technologies :",
"Principal Scientist . We craft computational solutions to facilitate the discovery and design of molecular therapeutics . We harness the power of Deep Learning , Structural Biology and Bioinformatics to help shape the therapeutics of tomorrow . . 8 years of research experience in Bioinformatics , computational and structural Biology . 15 publications in peer reviewed international journals Extensive hands on experience with protein structure modeling , protein docking and computational genomics . Broad knowledge and experience in areas related to macromolecular crystallography Well experimented with Machine Learning Methods and Deep Learning approaches . Profound knowledge in coding , web development , and new technologies . New technologies enthusiast , experience in web and smartphones development Self motivated , innovative scientist able to thrive in a multidisciplinary environment . Exceptional team player , very comfortable in a fast pacing collaborative environment . Experience in writing and reviewing research papers , proposals . Creative problem solving and supervising experience . Public speaking skills and experience in delivering an effective presentation . Programming and Computer Skills Proficient in many modern coding languages Python , Java , PhP , C , Objective C , Jquery Deep Learning Frameworks Tensorflow and Pytorch Database design and management RDBMS MySQL , Oracle , PostGreSQL NoSQL MongoDB Web 2.0 design HTML5 and CSS3 , PHP frameworks Kohana , CodeIgniter and smartphone applications iOS . Technologies :",
"Adjunct Professor . . Experienced Research Scientist with a demonstrated history of working in the biomedical academia . Skilled primarily in Structure based Drug Discovery and Patch Clamp , but also in Recombinant DNA , Computer Repair , Biotechnology , Cell Culture , and Life Sciences . Strong research professional with a Doctor of Philosophy PhD focused in Biomedical Sciences from Rutgers University . . Technologies :",small molecules
"Associate VP , Structural Biology . Discovering new therapeutics using atomic resolution insight . . So far my professional journey has taken me from basic to applied membrane protein structural biology research via drug discovery and product development to creating new business ventures . I have lead gene to X ray structure scientific research projects , managed a portfolio of research and product development projects and devised real life information systems and laboratory automation systems that are delivering business value to this very day . I hold five U.S. patents , have published more than 30 articles in peer reviewed journals , and have obtained several grants funded by the National Institutes of Health NIH for membrane protein crystallization and imaging technology development . I have enjoyed working with scientists at Johnson Johnson , Bayer Schering Pharma , Gilead , Biogen Idec , Hoffmann La Roche , Bristol Meyers Squibb , Vertex Pharmaceuticals , Merck Co. , Glaxo Smith Kline , Leidos , UCB , Astra Zeneca , Celgene , Heptares , Genentech and others . My hands on target expertise include membrane proteins : b2AR , beta 2 adrenergic receptor , Corticotropin releasing hormone receptor 1 CRF1 , prostaglandin E2 PGE2 receptor , glycerol channel GlpF , bacteriorhodopsin bR , sensory rhodopsin II SRII , outer membrane protein ompA , outer membrane protein ompF , light harvesting complex II LHCII , photosynthetic reaction center RC , acetylcholine receptor AChR , orexin receptor II OX2R as well as soluble proteins SHP2 Src homology region 2 SH2 containing protein tyrosine phosphatase 2 , plasma kallikrein , lactose permease LP , maltose binding protein MBP , Tyrosine protein kinase TIE 2 , tumor necrosis factor alpha TNF and various TNFRSF . I live on Bainbridge Island , WA , am married to a wonderful woman , and have one son . In my spare time , I enjoy exploring the Pacific Northwest by foot and kayak .. Technologies : Xray",membrane proteins;small molecules;structure
"Research Scientist . In my current position as a staff scientist at Stanford , my primary research focus is in translational molecular virology . Here , I study viruses and the host targets they co opt with the goal of discovering unique biology that can be exploited to create new broad spectrum therapeutic strategies . Of particular interest to me is how RNA viruses , like SARS CoV 2 and influenza , use their RNA genomes to guide biological processes . Armed with this knowledge , I help design and develop novel drugs against such RNA targets with the overall aim of not only stopping the current pandemic , but also preventing the next one . Description of role : Focus in antiviral target identification , drug discovery , and the preclinical development of novel classes of antiviral and host targeted therapeutics Scientific program manager helping to oversee a 41 M NIH contract to develop an enterovirus SARS CoV 2 therapeutic through Ph1 studies . Influenza virus research program manager for the lab , with oversight over the design and execution of experiments , assay development , as well as training mentoring of junior scientists and staff Significant expertise in nucleic acid and antisense drug design , targeting , and in vivo delivery . Developing high throughput small molecule screening technologies against RNA structure targets High level collaborator actively engaged with interdisciplinary and multi institute partnerships BSL2 certified with extensive experience in all aspects of virus and nucleic acid characterization in in silico , in vitro and in vivo assays . Virus experience in : SARS CoV 2 , human coronavirus , enterovirus EV71 , EV D68 , viral hepatitis HBV , HCV , HDV , influenza virus A B , flavivirus Dengue , Zika 1 US and international inventor patent for antiviral therapeutic . Stanford Microbiology Immunology PhD passionate about helping people through better science . I have 15 years of professional experience in a diversity of science related disciplines that enables a creative and cross disciplinary approach to problem solving . These include : Extensive experience in virology and drug development , from target identification and assay development to candidate selection and leading IND enabling studies . Program management overseeing scientific strategy , managing cross disciplinary teams , external clients , and CROs Strategy and due diligence consulting for individuals and companies from an array of fields including infectious disease , medical devices , personal health care , law , immuno oncology Diverse training and academic backgrounds in biochemistry and microbiology immunology , as well as philosophy . 10 publications in peer reviewed journals 2 inventor patents Adept writer public communicator . Technologies :",nucleic acids;small molecules;developing;interaction;screening
"Senior Scientist , Computational Biology . . Computational Synthetic Biology Leader Business Development : Customer relations Public Outreach Presentations to Potential Clients and Investors Systems Biology : Metabolic Pathways Flux Modeling Genomics Software Development : High Throughput Automation Data Collection and Analysis Systems Synthetic Biology Software Strain Protein Evolution : Library Design HT Data Analysis LIMS Data Driven Analysis : Scripting Annotation Pipelines Advanced Visualization Communications : Compelling Speaker Thoughtful Listener Clear , Intuitive PowerPoints Management : Departments Projects People Solid grounding in biology and bench work Data driven approach to strain and protein evolution An agile approach to rapid software prototyping and application delivery 14 years of experience applying systems biology to strain improvement 18 years of experience developing bioinformatics software 10 years of experience managing multidisciplinary teams of scientists and programmers Accomplishments : Pitched to investors and collaborators . Managed long term relationships with clients . Prepared project plans and budgets for proposals to clients Improved protein and biofuel strains as much as 5 fold , designing mutant libraries Filed 2 patent applications , numerous invention disclosures and over 30 peer reviewed public and proprietary research reports Directed and aided construction of robust user friendly bioinformatics platforms enabling strain development and evolution at four biotech firms Accolades : excellent leadership qualities a huge asset ... highly recommended quality deliverables that target real needs and have proven robust and valuable instrumental in building the informatics capabilities in the emerging fields of genomics and systems biology from the ground up hard working , committed and showed great creativity in problem solving above all , Doug is a great person to work with Specialties : synthetic biology , strain engineering , strain improvement , evolution , metabolic flux modeling , metabolic pathway analysis , systems biology , microarray analysis , project management , software development , computer programming , teaching , training , bioinformatics analysis , patent analysis , management of outsourcing projects , data mining , programming in PERL BIOPERL VB ASP Java JavaScript C SQL R BioConductor .NET . Technologies :",
"Associate Scientist Cell Biology . Developing bioassays in support of research program in the Chemical Senses to elucidate the cellular and molecular mechanisms of chemosensation . Conducting feasibility studies of novel heterologous expression systems . . Biologist Manager with a MS in Molecular Biology , 7 years of professional experience in the Pharmaceutical Industry and 5 years in Fragrance Flavor R D. Extensive expertise in Gene Therapy , small molecule characterization , new target identification and validation with focus on GPCRs . Record of innovative problem solving and development of new experimental tools including cell and enzyme based assays , stable cell line generation . Creative , analytical , focused , and detail oriented . Work equally productively both as an independent contributor and in collaboration with team members . Effectively manage multiple projects , set priorities and meet deadlines . Merck Award for Excellence 2011 . Specialties : Gene Therapy : Development and validation of AAV based therapies . AAV virus purification , characterization and QC . Molecular biology : molecular cloning , DNA RNA isolation and analysis , sequencing , WB , GF size exclusion chromatography , SiRNA knock down , membrane preps , protein isolation , radio labeling I 125 , P 32 , S 35 . Skillful user of plate readers , automated liquid handlers , spectrophotometers , multiplex RT PCR thermo cycler , flow cytometer . Assay development : calcium flux FLIPR , ELISA , cell proliferation , apoptosis , cytotoxicity , cAMP LANCE , cAMP HTRF , lipolysis , binding assays . Cell line development . Immunocytochemistry , immunostaining of unpermeabilized and permeabilized cells .. Technologies :",biologics;carriers;quality
"Senior Postdoctoral Fellow . Allosteric regulation of large protein complexes . Technology Data integration Computational Biophysics Structural Biology Bioinformatics Expertise : Protein mechanics and system 's biology by integration of molecular dynamics , cryo electron microscopy , cryo electron tomography , protein docking , cross linking mass spectrometry Allostery protein protein , glycan protein , lipid protein interactions Data integration , Python3 High Performance Computing Objects : Bacterial secretion system , Proton channels , Tyrosine kinase receptors , peptidases , GPCRs . Technologies : CryoEM",proteins;small molecules;interaction;structure
Senior Research Software Engineer . . personal website https : www.jkanche.com GitHub https : github.com jkanche . Technologies :,
"SVP and Research Director . I am the Research Director for a small analyst group focused on the pharmaceutical and biotechnology industry . We issue 6 reports a year advising our pharma clients on subjects such as systems biology , toxicogenomics , clinical biomarkers , and target and compound validation . Our reports are focused on the realistic opportunities in these areas and are written for the senior executive level reader . We are also interested in working with venture capital and boutique life science investment banks to help them identify realistic opportunities in therapeutics and biotechnology . . Ph.D. in Mechanical Engineering . M.S. in Mathematics and Computer Science B.S. in Mathematics 10 years in computational biology , artificial intelligence , adaptive computing . 16 years active and reserve duty in the U.S. Air Force . Last assignment on the staff of the Air Force Test Pilot School . Interests include biotechnology , manned space exploration , artificial intelligence , amateur visible and radio astronomy , marine biology , exobiology Specialties : Technology and financial analysis , venture capital due dilligence , strategic alliances , genomics , bioinformatics . Technologies :",
"Food Technologist . . I have a PhD in Food Technology from Lund University . My research was about whey protein powders and how the functionality and rehydration of the powder is affected by composition , heat treatment , and protein aggregation state . The research also involved powder particle characterization using different types of microscopical techniques in order to relate particle morphology to the composition and protein denaturation .. Technologies :",
"Director , Lab Head of Protein Sciences . . Protein Science Membrane Protein Crystallography Structure Based Drug Design Summary I am a membrane protein scientist with over 14 years of experience in leading and managing very high functioning teams . I have a passion for drug discovery and would love to help your organization tackle tough protein chemistry problems , especially membrane proteins . I earned my Ph.D. in Molecular Biophysics and Biochemistry from the University of Texas Southwestern Medical Center , where I performed Nuclear Magnetic Resonance NMR , X ray crystallography , light scattering , and microscale biochemical experiments on components of the SNARE membrane fusion machinery . After finishing my Ph.D. , I completed a postdoctoral fellowship at Novartis where I expressed and purified several G Protein Coupled Receptors GPCRs , Ion Channels , and other membrane proteins for drug discovery . At Emerald Bio , I was a Project Leader for a variety of GPCR and other membrane protein projects . At Roche , I was the head of the Nanopore and Attachment Protein Engineering Group . We developed a novel sequencing by synthesis approach that combines the best of protein engineering with the best of software , big data , and semiconductor design . After the first iteration of that product was completed , I joined HarkerBIO as the Chief Scientific Officer , where I had broad responsibility over project management as well as driving scientific excellence . Specialties Protein Science Membrane Proteins Structure Based Drug Design Fluorescence Spectroscopy Microfluidics Nuclear Magnetic Resonance NMR X ray Crystallography Immunofluorescence Confocal Microscopy Membrane Protein Purification and Reconstitution Start up and small business consulting . Technologies : Xray;SLS DLS;NMR",membrane proteins;interaction;stability;structure
"Director , Chemical and Exploratory Cell Biology . . Passionate scientist and research project leader with 7 years of experience in preclinical small molecule drug discovery Open and patient centric mindset with the goal to deliver innovative and transformative therapies for unmet medical needs Result driven and pro active with a making things happen attitude Management of a laboratory with direct reports as well as experience in matrix leadership of cross functional teams and international collaborations .. Technologies :",proteins;small molecules
"Technical Area Lead . Technical Area Lead for Exploration Technology . Responsible for managing the portfolio of USRA s tasks and deliverables related to R D in Quantum Computing , High Performance Computing , Machine Learning , Data Mining , Nanoelectronics , and Environmental Analytics . . I am focused on the development and integration of scalable algorithms and computing architectures . I 've been fortunate to work with amazing technical teams and execute on development and analysis of cutting edge optimization , machine learning and simulation algorithms and high performance computing HPC architectures . My current work centers on development , use and analysis of algorithms that work well with current HPC and quantum computers or inform requirements for future generation architectures . These algorithms are often based on combinatorial optimization , probabilistic machine learning or simulation covering a wide range of applications . In my PhD and postdoctoral research I improved scalability of climate models on supercomputers . I designed and implemented nonlinear and linear solver algorithms leveraging fast matrix calculations based on approximate factorization and diagonalization of subsidiary tensor products . I also developed and applied similar methods to simulations of ground water , dislocation dynamics , and stability analysis of binary alloys .. Technologies :",
"Lead Clinical Trial Leader . Oncology , Hematology ; Clinical Trials , First In Human studies . Accountable for all aspects of individually assigned oncology clinical trials including leading Clinical Trial Team . . Responsible for program level activities as assigned . . In addition to leading individually assigned clinical trial , First in human studies in Oncology and Hematology , also provides line management oversight to direct reports which comprise of clinical Team Leads and Associates . Early Clinical Development in Oncology : Cancer drug development First In Human trials for heme malignancies Multiple Myeloma ; Lymphoma New protocol design for Unresectable and advanced Melanoma Adapted drug combination treatment for advanced Gastric Cancers NSCLC Phase I II trials development Project Management of Clinical Trials in Oncology : Ovarian Cancer Phase III ; Lymphoma NHL Phase II ; Mantle Cell Lymphoma Phase III ; Solid Tumors Phase I for new compounds ; Program Manager for Gastric Cancer studies Phase I and III Genetic research : Molecular analysis of differential gene expression in Tumour Reversion . Protein expression and interactions studies in biological models of cancers . Patents and publications : molecular characterization of the tumour reversion pathways . Collaborations with Hospitals for the screening of Tumour Libraries . Leading collaborative research developments with pharmaceuticals labs Lynx Therapeutics or academic labs Memorial Sloan Kettering ; University of Geneva . Study of the implication of Siah1 in protein degradation Weizmann Institute published in PNAS . Cloning genes of interest and building cDNA libraries . Set up of new high throughput methods to improve the resolution of the physical map of the human genome . Construction of cloning and expression vectors . Building an experimental flow cytometer in collaboration with the Los Alamos National Lab USA for the sizing of BACs and DNA fragments . Specialties : Human Genetics Molecular Biology of Cancer Clinical Research in Oncology , Early development of new drugs . Technologies :",
Research Scientist . Initiated project to determine the dynamics in a phage DNA packaging motor by NMR Corrected a virus structural model by discovering a helical protein capsid by cryo electron microscopy . . Technologies : CryoEM;NMR,proteins;structure
"Biosafety Specialist . To ensure knowledge and understanding of regulatory demands in relation to biological safety of medical devices . To plan and prepare appropriate and compliant biocompatibility documentation for Coloplast products in development projects as well as for marketed products . To support the business in relation to questions related to toxicology , chemicals and safety for people . To stay on top of legislation for biological safety and chemical compliance . To develop and maintain procedures and instructions for biological evaluation activities . . Experienced biochemist with a demonstrated history of working in the biotechnology and pharmaceutical industry . Skilled in Customer Service , Life Sciences , and Microsoft Office . Bachelor 's degree focused in Biochemistry from Vilniaus Universitetas . Master 's degree in Pharmaceutical Sciences at University of Copenhagen . Deeply interested in biopharmaceuticals , manufacturing , drug formulation , protein aggregation .. Technologies :",proteins;stability
"Postdoctoral Fellow . . As part of the NIH funded Medical Scientist Training Program , I had the opportunity to train on the use of cryo EM for studying virus structure and assembly . I was drawn to the technology as it provided a unique perspective for studying large macromolecules and their complex interactions with each other . My PhD thesis focused on the use of cryo EM was in determining the structural proteins and mechanism for loading DNA into HSV 1 capsids . During my training I had the opportunity to test and characterize the digital detectors that have since revolutionized the field . My work with collaborators in Hematology and Oncology broadened my appreciation for what this technology and Structural Biology has to offer to the field of Medicine . Having seen first hand how this technology was able to directly address and answer questions that to date had evaded investigators , I was intrigued in its use for drug design and vaccine development which rely on an intimate knowledge of both structure and function of these complex macromolecules . Most of my experience in cryo EM has been with large dsDNA viruses and as my career transitioned to Pediatrics upon completion of my MD PhD training , my interest shifted to apply these skills in electron microscopy and 3D structural determination towards viruses of importance to this population . Ultimately , I feel this work has the potential to define the complex structural process behind replication , capsid assembly , and viral egress within this system . I am confident that a structural approach to understanding mechanisms of infectious disease , from assembly , to virulence and pathogenesis will provide insight into novel therapeutic development .. Technologies : CryoEM",nucleic acids;proteins;interaction;structure
"Senior lab manager . . Experienced Associate Researcher with a demonstrated history of working in the hospital health care industry . Skilled in Electron and Cryo electron microscopy , Epigenetics and OMICS . Technologies : CryoEM",proteins;structure
"Biophysical Development Scientist . . Scientist with significant research experience in structural biology , protein biochemistry and biophysics . My skills include protein expression , protein purification , gel electrophoresis , biophysical characterization techniques , small angle X ray scattering , light scattering , nuclear magnetic resonance , spectroscopic techniques , chromatography and analytical ultracentrifugation . I enjoy new challenges and adapt to new environments easily . Outside of science , I love experiencing new cultures , trying out new foods , dancing and painting .. Technologies : Xray;SLS DLS;AUC;NMR",proteins;characterization;expression;structure
"Director , Structural Biology and Chemistry . Develop and execute strategic plans to bring Gilead 's cryo EM to industry standard , provide effective structural support to virology , oncology and inflammation research pipelines . . Highly accomplished well recognized structural biologist with a passion for drug discovery . A wide network of industry and academic connections . Structure Based Drug Research . Extensive experience in using structural biology , biophysics and modeling techniques to facilitate biologics and small molecule pharmaceutical research pipelines . Science Technology . Well known structural biologist with rich experience in modern cryo EM and crystallography . Expert knowledge of soluble and membrane protein expression and purification with bacterial , insect and mammalian systems . Leadership . Results oriented and science based team leader with strong record of mentoring and team managing experience . Communication . Successful experience in designing and executing strategies operation plans , scientific exchange and team interactions . Strong organizational , interpersonal and communication skills . Strategy Operations . Demonstrated success in leading cross functional , cross site teams and building industry academic collaborative facilities .. Technologies : CryoEM",proteins;small molecules;structure
"Bioinformatician . Duties : genome annotation , short read mapping , SNP calling , differential expression , pathway analysis and gene ontology , help with software development . . For recruiters : I am interested only in actual real offers . If you have a real job offer , send me an ad salary first . Save yours , and my time . Thank you . CV on request . Bioinformatician , evolutionary biologist , a geneticist with a strong computer science background . Proficient in silico biological data analysis especially Next Generation Sequencing and microarray data . Proficient and advanced computer literacy , e.g. GNU Linux , PC hardware , clusters , bioinformatics software . R and Perl programmer .. Technologies :",
"Postdoctoral Fellow . Laboratory of Stephen Brohawn . Biochemist with broad experience across structural and cell biology . Work spanning dynamic protein complexes at the kinetochore and ion channels at the plasma membrane . Captivated by the molecular mechanisms at the heart of large scale cell biological processes . https : scholar.google.com citations user P1BpF6QAAAAJ hl en SKILLS Protein expression : Human , insect , yeast , and bacterial systems . Protein purification : Experience with flexible complexes and membrane proteins . Cryo EM : Sample prep and data processing . Structure modeling and analysis . Protein mass spectrometry : Complex discovery , development of cross linking methods . Electrophysiology : Whole cell and proteoliposome in vitro recording . Cell biology : Tissue culture techniques , live and fixed cell microscopy .. Technologies : CryoEM",membrane proteins;proteins;structure
"Postdoctoral Researcher . Structural Membrane Biochemistry Bavarian NMR Center BNMRZ Dept . of Chemistry Institute for Advanced Study Technical University of Munich . 8 years of lab experience in the field of protein structure function relationship with a comprehensive understanding of protein folding , dynamics and aggregation . Deep expertise in protein expression and purification systems , biochemical and biophysical assays for protein characterization including soluble and membrane proteins in the form of monomers or multidomain complexes . Expert in E. coli and S. cerevisiae cultures . Problem solving and analytical mindset .. Technologies : NMR",membrane proteins;proteins;expression;structure
"Principal Scientist Pharmacology Toxicology and Drug Metabolism and Pharmacokinetics DMPK at . Define , elaborate and coordinate the execution of feasibility research and lead optimization projects , within the company s strategy and inter national guidelines and regulations . As team leader I manage projects from pre clinical prove of principle , toxicity and safety studies to first in human . My responsibilities include generating new ideas for a variety of projects , developing new methodologies , initiating and coordinating the execution of pre clinical studies . Establishing and maintaining an international network : universities , contract research organizations and research institutes . As subject matter expert it is also my responsibility to advise colleagues on pre clinical issues and consultation with key opinion leaders world wide . . Experienced pharmacologist with management expertise and more than 20 years of experience in preclinical research projects in the pharmaceutical industry small molecules , biologics , antibody drug conjugates , non biological complex drugs and generics . In my current position as Senior Principal Scientist at the Department of Pharmacology , Toxicology , Drug Metabolism and Pharmacokinetics at Byondis BV , I define and coordinate the execution of innovative research projects , within the company s strategy , according to global guidelines and regulations . As team leader I manage projects from pre clinical prove of principle , toxicity and safety studies to first in human . It is my responsibility to initiate and coordinate the execution of pre clinical studies conducted by contract research organizations worldwide . . Specialties : PhD in neuro endocrinology , experienced pharmacologist , expertise in management and strong technical skills in R D research in the pharmaceutical industry , such as in vitro and in vivo pharmacology efficacy , toxicity and safety , biochemistry , molecular biology , clinical chemistry and hematology . Further , I have established a diverse scientific network with universities , profit and non profit organizations . . Technologies :",
"Associate Scientist . Develop and optimize methods for the purification of AAV using chromatography . Working to develop a low volume analytics panel for AAV using the latest technologies for AAV titer determination and genome sequencing . . Biochemist experienced in the expression , purification , and analysis of recombinant proteins and antibodies . Past projects include the construction and characterization of insoluble hexameric proteases and its substrates , and the purification of antibodies and antigens for various in vitro and in vivo programs . Current work includes platform development for rAAV production , and supporting in vitro and in vivo gene therapy programs .. Technologies :",antibodies;carriers;proteins;characterization;expression
"Postdoctoral Researcher . . Creative , independent and forward thinking scientist with a strong background in structure activity relationships of proteins . Interested in molecular neurobiology and drug design for memory disorders . Special expertise in the following areas : Recombinant expression of kinases and phosphatases in bacterial and insect systems Protein purification , characterization , in vitro bioconjugation , and activity measurement Peptide and small molecule synthesis Protein structure determination using cryo electron microscopy Excellent collaboration and communication skills as evidenced by team publications and a U.S. patent . Technologies : CryoEM",peptides;proteins;small molecules;characterization;structure
"Research Specialist Gonen lab UCLA . . My PhD project led me to investigate on the ultrastructure of nanoscopic membrane lined channels called plasmodesmata , which are embedded in the cell walls between plant cells , allowing them to communicate with each other . They establish a very special kind of communication , proper to the plant kingdom , called symplastic communication , by establishing a cytosolic and membrane continuum of the plasma membrane PM and the endoplasmic reticulum ER between the cells . The ultrastructural analysis of plasmodesmata was a formidable challenge given their nanoscopic size they can be as narrow as 20 nm in diameter , location embedded in the plant cell wall and their dynamic nature . Using electron tomography of high pressure frozen , near native plasmodesmata , I provided for the first time data on their 3D membrane architecture at an unprecedented resolution see panel aside , forcing a reconsideration of the current model W. Nicolas et al . , 2017 ; Yan et al . , 2019 . I was appointed at Caltech Pasadena , USA in January 2018 as a joint post doctoral scholar in two labs , the Meyerowitz lab , specialized in apical meristem development plant biology , and the Jensen lab , specialized in cryo electron tomography cryo ET method development . I investigated the structure of crystalline cellulose producing bacterium Gluconacetobacter hansenii and E. Coli by cryo ET to better understand the cellular determinants of the cellulose crystallization process W. J. Nicolas et al . , 2020 . Because plant tissues are notoriously thick , cryo ET requires thinning technics . Because of this limitation , I specialized in cryo Focused Ion Beam milling cryo FIB milling allowing to thin samples of a maximum thickness of 10um down to 200 nm . This allowed to investigate at high resolution the structure of the plant primary cell wall in the white onion Allium cepa . I am actively investigating cellular processes like exocytosis in the pollen tube by using cryo FIB milling on pollen tubes germinated in vitro and secondary cell wall formation in whole plant cells grown in vitro . The latter required the implementation of a novel technic called the waffle method Kelly et al . , 2020 . I am also involved in various collaborations on various projects in biology and chemistry requiring cryo FIB milling . Technologies : CryoEM",structure
"Scientist . HTS and kinetics . Experienced Associate Researcher with a demonstrated history of working in the biotechnology industry . Skilled in Label free Technology SPR , ITC , BLI , Laboratory Robotics , Cheminformatics , and Biotechnology .. Technologies : ITC;BLI;SPR",interaction;screening
"Principal Machine Learning Researcher . . I am passionate about applying my transferable experience in computational biology , data science , and machine learning to solve challenging problems . I am an experienced technical people leader in genomic data science and machine learning , with a proven track record of building high performance teams to invent and deliver scalable algorithms and predictive models to improve customer experience and support key business objectives across a wide assortment of domains . My experience has helped me to be successful in driving cross functional programs with over 20 scientists in human healthcare and consumer genomics while driving executive buy in . Currently , innovating ML methods for unbiased proteomics at Seer . At Ancestry , I led a team to develop scalable computational and machine learning algorithms for several products . Previously , I worked as a Research Scientist at Stanford Medical Genetics , developing a system to automate diagnoses of clinical exomes . I completed my Ph.D. at Stanford and my undergraduate degrees in EECS and Bioengineering at UC Berkeley .. Technologies :",
". . Protein biochemist with core expertise in protein expression , purification , biochemical and biophysical characterisation with an emphasis on therapeutic monoclonal antibodies . Track record of acheiving project goals through effective teamwork and collaborations . Skilled in the following areas : Molecular biology methods : Complex nucleic acid amplification PCR methods , whole cell PCR , RT PCR , qPCR . Cloning , restriction digestion , ligation , ligation independent methods , construct design . DNA RNA isolation , electrophoresis , purification , quantification , and sequencing . Protein purification : Microbiology methodology and Mammalian cell culture techniques . Recombinant protein expression and secretion in E. coli strains , Baculovirus , Hybridoma and HEK293 cell systems . Purification using affinity , size exclusion , ion exchange , reversed phase , hydrophobic interaction chromatography methods . Expression , purification and preparation of monoclonal antibodies . Biochemical and biophysical analyses using ELISA techniques , SEC MALS , SPR and NMR . Structural determination by X ray crystallography and cryo EM . Working in fast paced , cross functional project teams . Supervision , mentorship , and professional development of junior scientists and laboratory assistants . Specialties : Molecular Biology , Protein Biochemistry , Protein Engineering , Strain Development , Protein Crystallization , Structural Biology , Monoclonal Antibodies , Biochemical Assay Development .. Technologies : Xray;CryoEM;SPR;NMR",antibodies;characterization;engineering;interaction;structure
"Principal Scientist Cheminformatics and Combinations Lead . . A computational chemist and data scientist focused on AI , drug discovery and repurposing . Experience includes time spent in academia , pharma , tech , and at Healx a fast growing startup with a great mission to accelerate treatments for rare diseases .. Technologies :",
"Postdoctoral Researcher . . I am a Ruth L. Kirschstein postdoctoral fellow interested in the structural biology of GPCR signaling . I have experience in protein crystallography , cryo electron microscopy , protein purification , biochemical biophysical assays , and cell based assays . I also have experience in communicating my research and mentoring . Looking forward to the next opportunity I pursue . Technologies : Xray;CryoEM",membrane proteins;proteins;characterization;structure
"Director of Bioinformatics Engineering . . Proven leader , scientist and engineer with 15 years experience in the development of bioinformatics algorithms , tools and pipelines as well as analysis of Next Generation Sequencing NGS data . Most recently , played key leadership roles in developing a platform for storage , retrieval and analysis of NGS and high dimensional immune profiling data for Human Longevity and immunoSCAPE , respectively . Currently leading and building omics genomics , transcriptomics , proteomics and metabolomics tech capabilities in AstraZeneca , Cambridge , UK . Specialties : Bioinformatics , Big Data , Cloud Computing , Parallel Computing , DNA Sequencing , Genomics , Sequence Analysis , Algorithm Development . Technologies :",
"Pro Vice Chancellor for Research . . I hold the Foundation Chair as Professor of Mathematical Sciences at Liverpool Hope University where I am Pro Vice Chancellor for Research the Dean of Faculty of Science . I have been the Head of the School of Mathematics , Computer Science and Engineering at Liverpool Hope since January 2008 . A mathematician by training , I possess multi disciplinary expertise in Nonlinear Mathematics , Natural Computing , Bio Mathematics and Computational Biology , Operations Research , and Control Systems Engineering . I have an extensive background and experience of working in Universities in the UK and India . I have been an expert reviewer for the Biotechnology and Biological Sciences Research Council BBSRC grants peer review committees for Bioinformatics Panel ; Engineering and Physical Sciences Research Council EPSRC for High Performance Computing Panel ; and serve on the Peer Review College of the Arts and Humanities Research Council AHRC as a scientific expert member . I have edited volumes on Intelligent Systems , and Applied Mathematics ; I am the Editor in Chief of the International Journal of Artificial Intelligence and Soft Computing IJAISC and serve on editorial boards for a number of prestigious journals such as the Journal of Universal Computer Science JUCS . I am well published with over 200 publications in prestigious publishing outlets and international journals . I was awarded a prestigious Commonwealth Fellowship for pursuing my Doctorate DPhil in Applied Non Linear Mathematics , which I earned from the University of York in 1996 . I hold BSc Hons . , MSc , and MPhil with Distinction from the MDS University of Ajmer , India . Prior to joining Liverpool Hope , I was with the Department of Mathematical Sciences , and later at the Department of Systems Engineering , at Brunel University , London . Earlier I lectured at the Tata Institute of Fundamental Research TIFR , Applied Mathematics , Bangalore , BITS Pilani and the Indian Institute of Technology IITs in India .. Technologies :",
Specialist . . PROFESSIONAL FIELDS Protein design Protein engineering Next generation vaccine development Antibody engineering Ph.D. in Bioengineering with a strong structural biology computational biology background and more than 7 years of experience in the integration of computational simulation with experimental validation for solving the complex biological problems . I am have : A strong publication record in leading journals A productive independent researcher with a satisfactory level of knowledge of how to interact effectively with computational and experimental biologists Extensive technical and management experience in research groups projects . Technologies :,antibodies;biologics;proteins;engineering;structure
"Principal Clinical Scientist . Product Development Oncology . Ten years of experience in clinical development including three years of experience in line management 1 full time employee and one contractor . Clinical Science Experience . Disease Therapeutic Areas : Pediatric Oncology solid tumors and hematologic maligcies . Activities : . CDP development , clinical study designs development , development of clinical documents Protocols , ICFs , study related documentation , . Generation of regulatory documentations and regulatory interactions IBs DSURs updates , briefing materials , PIP PSP authoring , health authorities interactions and responses . Organisation , preparation and presentation of KOL meetings , advisory boards , Investigator Meetings . Medical monitoring , data review , and clinical data interpretation . Preparation of scientific communications scientific manuscripts posters preparation . Market Access Experience : . Disease Therapeutic Areas : Oncology Tumor Agnostic Histology Independent therapies . European Market Access University Diploma HTA assessments and policy , pricing and reimbursement , health economics . 6 months rotation in Roche Global Market Access Strategy . Participation in the development of integrated evidence plans to fulfil Payers HTA requirements . Clinical Operations Experience . Disease Therapeutic Areas : Autoimmunity , Neuroscience , Respiratory therapeutic areas , including rare indications . Activities : Responsible for planning , management , clinical execution of early phase clinical trials . Lead of multidisciplinary Clinical Trial Teams in the design , start up , execution , and reporting of First in Human , dose escalation , PK profiling , Proof of Concept Mechanism studies . Academic background : . PharmD University of Padova , Italy . PhD in Pharmaceutical Sciences University of Basel , Switzerland . Research focus : Small molecules Drug Discovery . Core Activities : Structure Based Drug Design , Lead identification , Modeling and Simulation , CYP450 interactions , and toxicology prediction . Technologies :",
Senior Scientific Software and Data Engineer at RCH Sanofi . . . Technologies :,
"Research Internship . Drug delivery , cleavage of proteins . Use of LC MS . Method development , running samples , preparing the tables in the computer , Data analysis . Interested in an internship as a Research Assistant in Molecular Biology , Neurobiology Innovation . Idealistic , creative , analytical and curious . When I was a child , I was extremely curious , always asking many questions and constantly asking my parents to show me documentaries . What I did n't imagine was that such small actions would be the beginning of my passion for science . Sixteen years later , I am surrounding myself with experiences and opportunities and having left for my first mobility program , Erasmus in Helsinki , working in a research group , and co directing remotely my own project I am a person very committed to the community in which I live . I have started representing students and volunteering in congresses , and It had developed in having taken part in several initiatives and projects . During this time , I have gained experience with the handling of material and the way of working in a laboratory , thanks to the great weight of the practical training of the subjects I have studied . 50 of the teaching load and 30 grades . And now I am in an Internship at the University of Helsinki in Drug Delivery . I am looking to expand my knowledge , add value , and make a difference in society from a scientific perspective . INTERESTED IN : Molecular Biology , innovation , neurobiology and ethology , drug delivery systems , synthetic biology , structural biology cryo EM , NMR spectroscopy , modelling , and virology . LAB EXPERIENCE During Internship : LC MS use for cleavage of peptides running samples , preparing the samples , preparing the tables in the program , and data analysis . During the Bachelor 's : DNA extraction , vector cloning , cell and microbiology cultures , PCR , in vitro enzymatic binding of DNA , the transformation of competent cells , sequencing data analysis , digestion with a restriction enzyme , preparation on an agarose gel for DNA electrophoresis , Neubauer chamber Hemocytometer , laminar flow cabinet , indirect immunodetection by fluorescence , tissue preparation , and microscopy , enzyme characterization , enzyme inhibition studies , chromatography , absorbance measurements , statistical treatment of data , among others . Technologies : CryoEM;NMR",carriers;formulation;structure
"Mechatronics Engineer . Mechatronics engineer in the instrumentation team , I am in charge of the development , construction and test of a standalone instrument for the characterization of Cryo EM sample grids . The aim is to measure , with a few nanometer accuracy , the thickness of a frozen sample at cryogenic temperatures . . Here are the main skills I have been developing those last years : Multiphysical modeling Electromagnetism , electromechanics , mechanics , fluid mechanics , Rapid control prototyping System control MPPT algorithms Signal processing Data analysis Experimental tests . Technologies : CryoEM",
"Associate Director , Quantitative Systems Toxicologist , GSK Associate Fellow . . . Technologies :",
Scientist Computational Biology . . . Technologies :,
Bioinformatics Research Scientist . I work on the Immuno Polymorphism Database IPD developing analysis pipelines for HLA and KIR sequence data as well as publication of this data in quarterly releases . . I am a Bioinformatics Research Scientist with nearly 6 years experience working on an international immunogenetics database project . I am looking for the opportunity to take the skills and experience I have developed over this time and apply them to new challenges in an applied research setting with real world outcomes . I have a focus on analysis of large genomic datasets including data mining and NGS analysis pipelines .. Technologies :,
Scientist . . Biochemist and Structural Biologist dedicated to understanding mechanisms regulating the function of membrane proteins and receptor complexes in human diseases .. Technologies :,membrane proteins;interaction;structure
"Senior scientist bioinfornatics . . Strong professional and self motivated individual with more than 10 years of experience in analysis of diverse biomedical data looking for a scientist position in computational biology bioinformatics data science algorithm development fields . I have worked on the algorithm development to address biomedical problems with computer science , statistics , mathematics , and engineering for 10 years since 2009 . Algorithms in my projects include machine learning , data mining , image processing , statistical modeling , and signal processing . Besides a strong background in mathematics , statistics and computer science , I also learned biomedicine including physiology , gene , neuroscience , and molecular biology . My other advantages : a good learner , an independent problem solver , and a strong self motivation personality .. Technologies :",
Research Fellow . . . Technologies :,
"Senior Scientist . . More than 10 years of experience in field of molecular and structural biology with extensive knowledge and proven background in design and development of strategies for effective protein expression and purification in expression systems such as bacterial , yeast , insect and mammalian cells . Creative , extensively curious scientific mind with critical , but , yet out of the box , non conventional thinking .. Technologies :",proteins;expression;structure
"Scientific Researcher . . I am a life science researcher with a deep fascination with the aging process . This interest formed during my university studies in molecular biology . It stayed with me during my brief delve into cancer research and finally made me enroll in PhD studies in one of Europe 's unique institutes focused entirely on aging . I have chosen a proteomics lab for my PhD study and got involved in a project regarding tracking protein protein interactions . During the studies I was able to use state of the art mass spectrometry instruments . My project involved construction of a unique model system that gives insight into proteasome interactome in both cells and animal models . We showed as a proof of concept that proximity dependent biotinylation technique can be successfully employed for tracking proteasome interactions in both static homeostatic conditions as well as upon different chemical challenges . It could be used for cell line model systems as well as mapping interactomes throughout different animal tissues . Exceptional performance of the model led to the filing for a patent regarding the concept behind it and its usage . In the immediate future , the model will be used for studying proteasome interactome changes in animal model upon aging . I am a big proponent of informational theory of aging as a major upstream cause of aging . For me its all about losing control . It 's about mistimed expression of certain genes on one hand or loss of expression of others . This in turn leading to subsequent reactivation or loss of certain gene networks at inappropriate time . I see a living organism as an immensely complex and big orchestra playing a demanding composition . For it to work all parts of the system need to play in tune . However , with time more and more members of the orchestra start to play slightly out of tune . The process is progressive , leading to the loss of quality all the way until the original tune is unrecognisable and a system colapse . I strongly believe in proximity based labeling performance and its suitability for studying mechanisms of both aging and regeneration . For this reason , I am very excited about the new stage in my career in which I am looking for positions allowing me to employ the knowledge I acquired during my PhD studies . I am also very excited about future and promise of PROTAC technology . Interested in ideas of using the same principle behind the technique to modulate proteasome activity .. Technologies :",
"Director , Scientific Computing . . . Technologies :",
"Principal Scientist , Quantitative Pharmacology and Pharmacometrics . . Scientific reseracher with extensive model based drug discovery and development experience across multiple therapeutic indications . Currently responsible to provide modelling support for several discovery and development project in oncology non oncology pipeline across different modalities . M S Experience : PBPK , PK PD , PK TOX , TK TD , Population PK , Tumor Disease Progression , IVIVC etc . Drug Development Experience : Translational PK PD , Efficacious Exposure Projections , Schedule and Dose Selection , Combination Development etc .. Technologies :",
Research Scientist Assoc . Adjunct Professor . . . Technologies :,
"Senior research associate . Developing and generating data in a R D laboratory , setting up laboratory experiments involving catalysing enzymes . For screening purposes automation , using various liquid handlers , is an important tool . Biophysical methods for analyzing protein stability : NanoDSF , DLS , DSC , ITC . Experienced Senior Research Associate with a demonstrated history of working in the biotechnology industry . Skilled in Protein Chemistry , Biophysics , SDS PAGE , Molecular Biology , Assay Development and Biotechnology . Strong research professional graduated from herlev statsskole . . Technologies : ITC;SLS DLS;DSC;DSF",enzymes;proteins;characterization;screening;stability
"Specialist . . Highly structured and self motivated scientist with broad a knowledgebase in chemistry , biochemistry molecular biology . 5 years of research experience in basic science incl . international stay . Experience from pharmaceutical industry within cGMP of small molecules and biologics Strong background in development , validation and implementation of analytical methods for small molecules and biologics . A proven team player able to work independently . First class problem solving skills . Experienced in design , statistical analysis and interpretation of experiments . Solid IT knowledge . Experience in : Analytical methods for small molecules and biologics , Analytical chemistry small molecules , Statistics , Regulatory requirements for pharmaceuticals , Protein chemistry and stability , Enzyme assays and kinetics , Structure activity relationships , Purification and Characterization of membrane proteins , Assay development , Analytical biochemistry of lipids , Detergents and Membrane proteins , Homologous and Heterologous expression systems , Strain generation , Yeast genetics , Cloning and DNA preparation .. Technologies :",biologics;membrane proteins;small molecules;developing;stability;structure
"Principal Scientist . . A results driven software engineer with expertise in multi tiered application architecture and development . Able to quickly grasp scientific and technical challenges and conceptualize innovative solutions . Adaptive to new languages and technologies . Expert in C , architecture , creative thinking and problem solving . Specialties : Desktop , web , and mobile applications : C , WPF , objective C , VB.NET , ASP.NET Web standards : CSS , HTML , XML , RDF , JSON , SOAP Agile development with Scrum Database design and development : Oracle , SQL Server , MySQL Performance analysis and tuning of application and database systems Analytical chemistry , process development , and pharmaceutical manufacturing Application of design of experiments to drug development . Technologies :",
Senior Machine Learning Researcher . . . Technologies :,
"Scientific Researcher . Probing the structure and dynamics of enzymes involved in anaerobic metabolism and carbon fixation . Understanding the enzymatic machinery used by anaerobic microbes could inspire potential applications in CO sequestration and biofuels production , leading us to tackle the current climate change crisis . Use of Cryo electron microscopy to decipher the structure of enzymes under anoxic conditions . Planning , management , and execution of the research project along with the teams at the Goethe University and SYNMIKRO research center . . . Technologies : CryoEM",enzymes;structure
Bioinformatics Scientist . . . Technologies :,
"Senior Protein Scientist Hays consultant . . I am enthusiastic , ambitious , and passionate to explore the field of protein science in a dynamic and successful pharmaceutical company working alongside highly skilled scientists . As a Postdoc , I bring significant knowledge in molecular biology , protein engineering , and biophysical characterisation of proteins . I have extensive experience with expression and purification of recombinant proteins , including membrane proteins . My passion for research , work experience , and communication skills have enabled me to be efficient and effective , both individually as well as in a team . Molecular biology Polymerase chain reaction , cloning and site directed mutagenesis DNA purification and agarose gel electrophoresis Protein expression and purification Protein expression in pilot and large scale including fermenters Soluble and membrane proteins including synuclein Protein purification using kta Biorad systems including reverse phase chromatography Protein analysis using SDS PAGE and Western Blot , dialysis and concentration determination Protein characterization techniques Microscale thermophoresis MST , fluorescence anisotropy , Far Western Blot , surface plasmon resonance SPR , circular dichroism spectroscopy CD , dynamic light scattering DLS , nano differential scanning fluorimetry nanoDSF , ELISA , HCP and gyrolab , crystal screen and optimization , negative stain electron microscopy , small angle X ray scattering SAXS Currently gaining hands on experience with NMR spectroscopy Bioinformatics tools for sequence alignment , UniProt , Swiss PDB , pymol , and ATSAS . Gaining experience on NMR data acquisition and analysis tools . Technologies : Xray;SLS DLS;SPR;MST;DSF;CD;NMR;FP",proteins;characterization;engineering;expression;interaction
"Senior Director , Computational Biology . . . Technologies :",
Chief Scientific Officer . www.interxinc.com . . Technologies :,
"Staff Scientist , Computational Biology . Exai Bio is developing a unique RNA based liquid biopsy for early detection and monitoring of multiple cancers . . Computational Geneticist Studying Cancer Genomics . PhD in physics experimental condensed matter . Extensive experience in experimentation , statistics , data analysis , machine learning , and thinking about the big picture . You can find my publication list on google scholar : https : scholar.google.com citations user mcBYLM8AAAAJ hl en . Technologies :",
"Scientist Protein Analysis . Binding Analysis between Antibodies and Antigens . Biolayer Interferometry Octet Red96e . Antibody Screening . Development and Establishments of Methods for Incoming Goods Control . ELISA , Western Blot , Native PAGE , Isoelectric Focusing . . Technologies : BLI",antibodies;interaction;screening
"Medical Specialist Project Leader . . 10 years experience as a pharmaceutical researcher with innovative mindsets and solid expertise in design of advance delivery systems nanomedicines via pulmonary , oral and parenteral routes to tackle the biological barriers and unfavorable properties of biotherapeutic agents e.g. peptides , siRNA ; Substantial experience in a variety of pharmaceutical technologies e.g. spray drying , freeze drying for solid formulation development guided by QbD tools , e.g Design of Experiments DoE , and Process analysis Technology PAT ; Well trained and experienced project leader manager with proved track record of the management of early research projects , as well as the commercial development project ; Optimistic , easy going , self motivated , and learning fast .. Technologies :",biologics;developing
"Professor Phd . Own research My research group is focusing on 3D structure determinations of ion channel receptors in the central nervous system . We are one of the leading groups in the field of ionotropic glutamate receptors iGluRs and can now produce ligand binding domains LDBs of nine different iGluR subunits for structural studies . The group accounts for 20 of all structures of iGluRs deposited in the Protein Data Bank ; i.e. 70 in year 2016 . This significantly advances our ability to perform structure based ligand design of iGluR targeting compounds . In 2008 2013 , I functioned at Head of GluTarget , a project initiated under the Programme of Excellence at the University of Copenhagen . The aim was to obtain novel structural and functional understanding of iGluRs at the molecular level by integrating multidisciplinary technologies and expertise ranging from biostructural studies over medicinal chemistry and chemical biology to pharmacology . This constellation was quite unique in Europe and has received very positive international evaluations . Extensive experience with national and international collaborations exists in the group . In 2008 , we also initiated structure determination of Cys loop receptors and in 2016 neutron macromolecular crystallography NMX on iGluRs a new method to be introduced in Denmark . Expertise Structural biology on soluble and membrane proteins including recombinant expression and purification , biophysical characterization e.g. isothermal titration calorimetry , protein X ray crystallography use of synchrotron radiation sources , analysis of protein ligand and protein protein interactions , structure based ligand design , ionotropic glutamate receptors . . Academic Degrees : 1986 , M.Sc . pharm . , The Royal Danish School of Pharmacy RDSP 1988 , PhD , The RDSP Cheminova Agro A S Employments : 1986 1988 , Industrial PhD student Erhvervsforsker , The RDSP Cheminova Agro A S 1988 , Teaching assistant , Dept . of Organic Chemistry , The RDSP 1989 1992 , Post doc , Dept . of Medicinal Chemistry , The RDSP 1993 1994 , Senior scientist , Dept . of Medicinal Chemistry , The RDSP 1995 2008 , Associate professor , Dept . of Medicinal Chemistry , The Danish University of Pharmaceutical Sciences 2008 2016 , Professor MSO in structure based drug design , Dept . of Medicinal Chemistry , University of Copenhagen KU 2016 present : Professor in experimental structure based drug design , Dept . of Drug Design and Pharmacology ILF , University of Copenhagen KU Major Committee Assignments : 1999 2002 : Member of Board , the Dansync Center for synchrotron radiation 2002 2008 : Member of departmental board , Dept . of Medicinal Chemistry , DUPS and Deputy Head 2004 2008 2004 2012 : Member of Academic Council , DUPS and KU 2004 2006 : Member of committee for defining central and prioritized research areas , DUPS 2005 2007 : Member of scientific committee , Dept . of Medicinal Chemistry , DUPS 2007 : Member of committee for preparation of strategy plan 2007 2010 , PHARMA , KU 2007 2012 : Director of Drug Research Academy , an industry oriented research education programme at DUPS KU 2008 2013 : Head of GluTarget , project within the Programme of Excellence at KU . 24.5 mio . kr 2010 2012 : Member of board , SHARE 's Cross Faculty PhD Initiative , KU 2010 2012 : Coordinator of mobility PhD grant on project Ion channel receptors in brain diseases 2012 present : Member of Research and Innovation Committee , ILF , KU 2015 2018 : Appointed Member of The Danish Council for Independent Research , Natural Sciences FNU and member of Executive Committee 2017 2018 2016 : Member of the PIPPI Advisory Board , an Innovative Training Network ITN under Horizon 2020 , DTU . Technologies : Xray;ITC",membrane proteins;characterization;expression;interaction;stability;structure
"Postdoctoral Researcher . . Chemical and structural biologist with experience in cryo EM , translating targeted protein degradation to bacteria .. Technologies : CryoEM",molecular glues;proteins;structure
"Director of Bioinformatics , Biologics Engineering . To lead the development of an end to end data management and analysis strategy and capabilities that will significantly impact the delivery of the novel biologics drugs of the future . Biologics Engineering is responsible for the discovery and optimization of next generation and novel biologics across all AstraZeneca therapy areas , providing innovative drug discovery capabilities to drive portfolio drug projects . . Innovator with the ambition to make genetically programming cells a reality in the true sense of the word programming , by precisely predicting how changes to the genetic code of a cell will affect its behaviour . Pioneer in the development of programming languages for molecular and genetic circuits , which automatically generate computational models of behaviour from annotated DNA sequences . Leader in Synthetic Biology with experience leading high performing multidisciplinary teams at the intersection of computational modelling , lab automation and machine learning . Led research on learning computational models of cell dynamics from experimental data and on predicting interactions between DNA molecules from sequence . Inspired by the potential of combining machine learning methods with domain knowledge in the form of automatically generated computational models , to predict the behaviour of a cell from changes to its genetic code . https : ph1ll1ps.github.io . Technologies :",
Senior Scientist . Protein Therapeutics API Development . Promote the development of innovative digital technologies and manage process optimization activities for the manufacture of monoclonal antibody therapeutics . Responsible for leading the Advanced Process Control BTDS group that uses process analytical technology such as Raman spectroscopy and MVA modeling analytics to promote the transformation of drug substance production processes into a digital manufacturing platform .. Technologies :,biologics;developing
"Research Scientist . . Researcher in Molecular Biology and Biotechnology . Did a 4 year Post doc . at NTNU Biotechnology in the field of Structural Biology and Protein Crystallography , with an 11 months visit in the Macromolecular Structure Group headed by Mirek Cygler , Montreal , Qc Defended my Ph.D. thesis entitled Structure Function Analyses of Mannuronan C 5 epimerases A Family of Modular Type Enzymes with an Applied Potential in january 2004 . My current ambition is to continue doing Molecular Biological research . Specialties : Standard molecular biology and microbiology techniques including e.g. DNA extraction and manipulation , PCR , protein purification and crystallization , etc .. Technologies : Xray",proteins;structure
"Director , Bioinformatics Research Group . My group develops bioinformatics software and databases to accelerate scientific research , including the Pathway Tools software , and the EcoCyc and MetaCyc databases . . . Technologies :",
"Principal Scientist . . Protein biochemists and structural biologist with 10 years of experience of protein construct design , expression , purification and structure and biophysical characterization , managing multiple research projects in following areas : Protein structure biology Protein expression and purification Protein engineering Membrane protein biochemistry and biophysics Technical Skills Protein construct design and screen : Cloning General molecular biology procedures including PCR , restriction enzyme , LIC , Gibson assembly , mutagenesis , etc . , FSEC Protein expression : E.coli , Mammalian cell HEK cell with baculovirus , Hybridoma , insect cell SF9 , Hi5 , and yeast Pichia , Saccharomyces Protein purification : AKTA systems Affinity , IEX , SEC , protein A , etc . , HPLC Protein characterization : Circular Dichroism CD , SEC UV MALS RI , Isothermal Titration Calorimetry ITC , SDS PAGE , Western blot , Silver staining , Pull down assay , MALDI TOF Protein Structure : X ray crystallography manual and robotic crystallization , synchrotron data collection and analysis , experimental phasing and molecular replacement . Program : CCP4 suite , HKL2000 , XDS , Phenix , coot , pymol , chimera , Small angle X ray scattering SAXS , Negative Staining , Cryo EM Program : EMAN2 and relion , modeling Modeller . Technologies : Xray;CryoEM;ITC;CD",membrane proteins;proteins;characterization;engineering;interaction;stability;structure
"Biomedical researcher . . RESEARCH EXPERIENCE . Biosensor design for hapten detection 2011 2013 . Biosensor design for albumin detection 2011 2013 . Magnetic nano gold particle synthesize 2011 2012 . Biosensor design for cancer biomarker epidermal growth factor receptor detection 2013 2014 . Lateral flow design for screening EBV VCA specific IgA in nasopharyngeal carcinomas 2014 2015 . Lateral flow design for Screening of IgA Deficiency 2014 2015 . Biosensor design for DNA methylated detection 2018 2019 . Biosensor design for glucose detection 2017 2019 . Biosensor design for HbA1c detection 2017 2019 . Lateral flow design for Screening of Covid 19 2020 . Biosensor design for cTnI detection 2021 . PROFESSIONAL EXPERIENCE . Medical laboratory expert Full time : 2011 2013 . Imam Khomeini Hospital , Tehran , Iran . Quality control manager Full time : 2013 2015 . Quality control of biochemistry kits in Man company , Tehran , Iran . Quality control consultant Part time : 2015 2020 . Quality control consultant in Man company , Tehran , Iran . Production Manager Full time : 2020 . Production manager in Arvin BioHealth , Tehran , Iran . TECHNICAL SKILLS . Microsoft Office . Photoshop . Fabrication and Modification of Sensors and Biosensors based on : . Electrochemical . Electrochemical Impedance Spectroscopy . Electrochemiluminescence . Field Effect Transistors . Lateral Flow . Cellulose Fiber Production by Electrospinning . Antigen and Antibody Immobilization on Biosensor Surface PVA , Tiophen , Reduced Graphene Oxide . Gold Nanoparticles Synthesis Using Various Kind of Reducing Agents such as Sodium Citrate , Tannic Acid , and Glucose . Iron Oxide Nanoparticles Synthesize Ammonia and NaOH . Core Shell Fe Au Nanoparticles Synthesis . Core Shell Fe Chitosan Au Nanoparticles Synthesis . Carbon Dot Synthesis . Silver Nanoparticles Synthesis . MOF Synthesis . Au nanocluster Synthesis . Protein Concentration Assay Bradford . Cell culture . Bacteria Culture . Polymerase Chain Reaction PCR . Electrophoresis Agarose gel . Blood Sampling . Medical Biochemistry Techniques . Elisa Technique . Medical Laboratory Expert Biochemistry , Immunology , Microbiology . Quality Control Techniques Accuracy , Precision , Recovery , Linearity , LoB , LoD , T Test . Method Validation . GMP . Quality Policy . ISO 13485:2016 . Technologies :",
"Director Of Bioinformatics . . Accomplished leader of technical and scientific teams in bioinformatics and computational biology with strong and diverse background in research and development , project management and customer support . More than ten years of experience in developing and applying computational methods and tools for analysis of genomic and molecular data . Cancer and Viral Genomics . Expertise in cancer genomics and epigenomics , variant calling including SNV , indwells , CNV and fusion , patient stratification , pathway analysis , machine learning , univariate and multivariate regression , feature selection , overall survival and recurrence analysis . Experience in identifying biomarkers and disease associated targets by multi data type integration via using public and proprietary data . Clinical trial data support , resistance monitoring and analysis . Extensive experience in statistical analysis , technical writing as well as customer and marketing support . Strong background in statistics , biophysics and molecular , structural and genome biology . High proficiency in Perl including bioperl , Python including Django , C C , awk , Windows and UNIX platforms . Working knowledge in R Bioconductor , JMP , Pipeline Pilot , SQL query and database development and validation including Oracle SQL developer . Experience in management of internal and external collaborations and projects . Self driven , focused and highly skilled in bringing scientists together from different disciplines to achieve goals and bridging knowledge divides among them . Comfortable with multitasking in a fast pace environment while delivering high quality results to meet deadlines . Specialties Bioinformatics , virology , oncology , next generation sequencing , digital PCR , genomics , epigenomics , transcriptome analysis , ultradeep sequencing , customer support , molecular and structural biology , atomic force microscopy , high throughput data analysis , relational database management system .. Technologies :",
"Senior Researcher . . I am a neuroscientist with more than 15 years of both industrial and academic experience in in vivo and in vitro models of pathological protein aggregation in neurodegenerative diseases , transgenic technologies such as somatic transgenesis with viral vectors and CRISPR Cas9 , and preclinical project management . Experienced Senior Researcher with a demonstrated history of working in the pharmaceuticals industry . Skilled in Molecular Genetics , Molecular Neuroscience , Flow Cytometry , Microscopy , Creative Problem Solving , Collaborative Problem Solving , and Biophysics . Strong research professional with a Doctor of Philosophy Ph.D. focused in Biochemistry and Molecular Biology from University of Helsinki .. Technologies :",idps
"Scientist I , Computational Chemistry . . . Technologies :",
"Senior Research Scientist . Delivery expertise in the area of construct design , recombinant protein expression , purification and characterisation to facilitate drug discovery projects . Delivering high quality , tailor made protein for assay development , crystallography , HTS , SPR , NMR and DNA encoded library screening . Collaborating with multi discipline team to facilitate the success of drug discovery projects . Developing and prioritising work plans over agreed timelines to meet the objectives of the project . Establishing semi automated processes for rapid protein production . Maintaining awareness of current developments and evaluating new technologies to continuously improving team s capability . Mentoring students to accomplish new scientific discoveries . Advocating the value of inclusion diversity . . I love to push scientific boundaries to develop efficient process and drive drug discovery project forward . To accomplish this , I focus on identifying key results , meeting timelines , open minded to new scientific innovation and tirelessly learning to wider my prospective . Specialties : Molecular cloning Recombinant protein expression , purification and characterisation Structural Biology Biophysics Automated Parallel Purification Sector Knowledge : Early Drug Discovery Research Protein Science Membrane Protein Process Designer . Technologies : SPR;NMR",membrane proteins;proteins;interaction;expression
"Computational Scientist I . Group : Cancer Data Science A major obstacle for treating cancer is a lack of precision medicines . Many potential targeted therapies fail to transition from preclinical models to patients due to incomplete knowledge of the drug s mechanism of action and or absence of robust biomarkers to identify relevant patient populations . As part of the Target Discovery and Advancement arm of the Cancer Dependency Map project depmap.org , my primary goal is to provide the oncology community with potential drug targets that have a high likelihood of success . We use machine learning methods to identify molecular features mutation , expression , methylation that are predictive of sensitivity to gene target inhibition CRISPR Cas9 , RNAi . This information provides insight into the target s function in cancer , helps us to generate therapeutic hypotheses , and guides us in nominating targets that are most likely to translate to patient tumors . Collaborations : modeling hematologic malignancies using CRISPR genome engineering created analysis pipeline available via http : crispr seq.com , discovering genetic dependencies specific to pediatric cancers , and other pan cancer studies centered around functional genomics . . I 'm interested in cancer precision medicine , particularly the application of machine learning tools to therapeutic target discovery . Technologies :",
"Manager , Downstream MS T Senior Scientist . . MS T Downstream Senior Scientist in Biopharmaceutical Industry . Previous experience as Tech Transfer Team Lead for Cell Therapy Facility and Process Scientist in both Upstream and Downstream mAb manufacturing . MSc in Immunology , BSc in Biomedical Sciences . Cert in Biopharmaceutical Operations at National Institute for Bioprocessing Research and Training NIBRT . Record of research into tumour immunology and treatment development . Excellent interpersonal skills with the ability to develop strong relationships with colleagues and key leaders across a diverse range of scientific disciplines .. Technologies :",
"Scientist II , Computational Biology . . Scientist with broad domain knowledge in genomics , biology , and data science . I have in depth experience with data wrangling , advanced statistical analysis , and machine learning using R Python . This comes from a diverse background in benchwork and bioinformatics for designing and executing next gen sequencing projects . Over the years I 've built a strong track record of teamwork and collaboration with US and international teams for efficient execution of both large scale and targeted pilot projects .. Technologies :",
"Head of Discovery Sciences . . Passionate about innovative drug development . Highly experienced in scientific management and coaching of multidisciplinary project teams discovering biologics from inception , over proof of concept to transition into early development . Solid track record of generating multispecific therapeutic candidates to a. o. GPCRs , solute carriers and ion channels for immuno oncology , neurology , infectious and inflammatory diseases . Strong proponant of industry academia collaborations . Extensive expertise in affinity maturation , engineering and NGS based discovery of biologics . Analytical and problem solving mind set . . Technologies :",antibodies;biologics;developing;engineering
"Scientific Director , Oncology Data Sciences . . More than 15 years experience conducting research in Computational Biology , Machine learning , Artificial Intelligence AI , Statistics , Genetics , and Molecular Biology Expertise in building synergistic teams , motivating individuals , and devising scientific strategies to deliver effective and innovative data science solutions for drug development Broad knowledge and experience in multiple therapeutic area including oncology , immunological diseases , rare diseases , and neurological diseases Expertise in leading conducting analysis of high dimensional OMICS data and electronic health records EHRs to impact target identification validation , drug 's MOA , patient stratification , and clinical development Expertise in identifying genetic causalities and investigating drug response in rare diseases and complex disorders from whole genome exome sequencing Biomarker expert on precision medicine Effective collaborations and communications with biologists , clinicians , chemists , statisticians , and data scientists Expertise in leading cross functional and academic collaborations with high impact publications . Technologies :",
"Ing nieur de recherche . Membrane Biochemistry and Transport Thomas Wollert team Department of Cell Biology and Infection . Transmission electron microscopy : Tokuyasu cryosectioning technique for immunolabeling Correlative light and electron microscopy Proficient in SerialEM , Imod and Amira software Formation Image Processing for Electron Microscopy tomography in 2021 Cryo Electron microscopy : Cryofixation on Vitrobot and Leica EMGP and Data aquisition on Glacios Cellular biology , Immunofluorescence Molecular biology : Cloning , PCR Recombinant protein expression Procaryotes and eucaryotes system Purification on akta system Chromatography Western Blot Crystal growing experiment . Technologies : CryoEM",membrane proteins;proteins;structure
"Senior Scientist , Computational Biology . Support the development of clinical biomarkers and diagnostics supporting Amgen programs through the assessment of biochemical coverage , patient stratification , indication selection in Amgen s early and late clinical development programs and discovery of clinical insights at asset and portfolio levels through the application of knowledge discovery and data mining techniques Represent the clinical biomarkers diagnostics team in Amgen program portfolio teams as a biomarker analysis lead Develop tools for data integration , management , visualization , analysis and presentation and provide leadership and expertise in those domains . Bioinformatician and quantitative thinker with experience developing and communicating efficient algorithms and statistical modeling pipelines for integrative analysis of large scale genomic and biomedical datasets .. Technologies :",
Undergraduate Research Assistant . Research Assistant for Professor Volker Vogt and Dr. Robert Dick in the Department of Molecular Biology and Genetics in the College of Agriculture and Life Sciences at Cornell University . Analyzed the molecular structure of Jaagsiekte Sheep Retrovirus JSRV and other retroviruses in vitro utilizing single particle cryo electron microscopy . Conducted viral release and infectivity studies in vivo utilizing immunoblotting and flow cytometry instrumentation . Proactively communicate with other scientists to clearly describe project objectives and results as part of Cornell University 's Molecular Biology and Genetics REU program . . Detail oriented honors student with a passion for resolving current health related problems . Experienced in sterile lab technique and microscopy . Eager to develop creative problem solving abilities through expanding my research experiences . Adept at learning new communication techniques and laboratory practices .. Technologies : CryoEM,proteins;structure
"Senior Research Scientist . . Experienced CMC Senior Scientist , Analytical development and characterisation Analytical development of small molecule , peptide and protein drugs from Pre clinical to Early Late Phase Development Acting as analytical responsible within global development projects Performing monitoring reporting method development , method validation and stability testing Specification setting Performing impurity degradation product investigations Performing forced degradation studies and candidate drug evaluation Outsourcing development GMP analytical testing to external partners Compiling reviewing CMC regulatory documentation Performing preformulation work and formulation screening Acting as Principal investigator for GLP formulation analysis , outsourcing GLP work . Technologies :",peptides;proteins;characterization;stability
Scientist and project leader . Scientist and and project leader within Nouryon s agricultural section . Fredrik focuses on innovaiting biodegradable surfactants polymers for the agricultural society . . Fredrik Andersson is a self motivated scientist with social competence and experience as project manager and commercial roles . 15 years experience from the Life Science Chemistry field both in academia and industry on a national and an international level . Superior know how in the below skills : Protein Science and biophysics Research Surface chemistry Surfactants detergents polymers Project management Technical sales Product development . Technologies :,proteins;characterization
Computational Scientist II . . . Technologies :,
Senior scientist Antibody discovery . Discovery and development of therapeutic antibodies to interrupt pathological fibroblast driven immune signalling . . Technologies :,antibodies;developing
Doctoral Researcher . Application of cryo electron tomography cryoET subtomogram averaging STA to elucidate molecular structures in mammalian cells for biomedical research Institute of Neuropathology RG Prof. Dr. Fern ndez Busnadiego . Any sufficiently advanced technology is indistinguishable from magic . Arthur C. Clarke . Technologies : CryoEM,proteins;structure
"Product Owner . Since January 2020 I have taken the role as Scrum Product Owner , leading development of the software for an upcoming instrument . As user friendliness is one major driver for the overall project , I coordinated a team designing the UX in advance of the project start . I also participate in coordinating with the hardware project as acting Product manager for this development project . Using my experience from Application Development and Customer Support really helps me driving the user requirements and aligning the development teams towards those goals . . As an Innovation development specialist , I bring science and technology ideas out of their bubble to transform them into useful and needed products and methods . Activities I am involved in include : Developing Technology and applications in biophysics and surface science Supporting future growth into key application areas by building networks and scientific knowledge Developing instrumentation and methods to facilitate novel biochemical experiments Optimizing prototypes for usability , reliability and robustness . Technologies :",
Team Leader Chemistry . Team leader for a team of synthetic chemists . Lead chemist responsible for progressing the chemistry program in projects from hit identification up to lead optimization . Project leader for a drug discovery program leading a multidisciplinary science team during lead identification . . Research interests : Phenotypic screening and how more relevant in vitro screening systems can be applied to aid hit identification and compound optimization . Application of computational chemistry methods to facilitate drug discovery research in particular around structure based drug design and modeling protein ligand interactions for GPCR and nuclear hormone receptor targets .. Technologies :,membrane proteins;small molecules;interaction;screening
"Research Scholar : Computational Biology . Research Project : DNA codes within non coding regions of the human genome . I hold a bioinformatics computational biology PhD , and possess strong analytical and experimental design skills . I am self motivated , independent and creative . My expertise is in transcription regulation , and my goal is to study this by deriving biological meaning from both sequence and genomic data . I have a wide skill range , from C programming and Python in the Linux environment , to data analysis and interpretation . . Technologies :",
"Undergraduate Researcher . Researcher at Dana Farber Cancer Institute Harvard Medical School Developing methods to impute gene expression into GWAS data to identify gene disease associations Leveraging both Allele Specific Expression and eQTL Data to deduce SNP gene relationships Working with Python , R , Celery , ASE Data , eQTL Data . PhD student at Stanford University interested in computational biology research . Technologies :",
"Senior Bioinformatics Data Scientist . . I am a programmer , a data scientist , a computational and experimental biologist . I am interested in data science , bioinformatics , and human genetic research .. Technologies :",
"PhD Fellow . Identification of lipid changes associated with Parkinson s Disease and alpha synuclein pathology in dopaminergic neuronal cells A GBA KD model is developed in SH SY5Y neuroblastoma cell line . shRNA is used to introduce 50 80 KD of the GBA gene in the beforementioned cell lines . Cell line expertise : SH SY5Y , Human fibroblasts , IPSC 's , NPC 's . Passionate scientist with great interests in molecular biology , neuropharmacology and biophysics in relation to development of strategies for diagnosing neurodegenerative diseases such as Parkinsons Disease . My current research focus is to identify lipid changes associated with Parkinson s Disease and alpha synuclein pathology in dopaminergic neuronal cells . I possess a broad range of cell culturing skills , skills within molecular biology qPCR , molecular cloning , protein expression purification , enzyme assays and I have great expertise in analytical methods f.ex . Lipidomics , DNA sequencing , GCMS , HPLC , Western blot , Seahorse extracellular flux analysis , Tht aggregation experiment , Dynamic Light Scattering and Circular Dichroism . I love new challenges and I 'm constantly seaching for new ways to improve . I have experience within the pharmaceutical industry , clinical pharmacy , fundamental research , university teaching and I have nine years of lab experience .. Technologies : SLS DLS;CD",enzymes;characterization;stability
"Research Fellow . . I have achieved my BSc degree in Information System , MSC in Computer Forensics and PhD in Machine learning . The outcome of this degrees has enabled me to develop skills in methodological problems , projects management analysis , computing network , security and analysing the trend of new research for the nearest future . I have experiences in the ability to work with a diverse range of people and having energy and enthusiasm in pursuing projects . I can work independently using my own initiative or as part of a team , problem solving , events management , excellent communication and time management skills , numeracy competence and understanding of numerical data , statistics and graphs .. Technologies :",
"Senior Scientist , Computational Chemistry . . I am a computational chemist working in working in the field of computer aided drug design . Proficient in both ligand and structure based methods with a specialization in docking , virtual screening , molecular dynamics , and free energy methods . . Technologies :",
"Associate Professor of Structural Biology and Senior Lecturer . Structure function characterization of membrane remodeling proteins Amyloids and neurodegeneration Cryo EM and 3DEM reconstructions Mitochondrial dynamics and cell death . We 're recruiting another postdoc if you are interested in working with cryo EM helical amyloid processing with awesome colleauges in an exciting environment , contact me . Technologies : CryoEM",idps;characterization;structure
"Principal Scientist Discovery and Development PK PD . . Accomplished scientist with more than 20 years of experience leading teams and providing PK PD and DMPK support , including modelling and human dose PK predictions from Hit to Lead to the clinic Previous experience supporting programs in metabolic disease , CNS , dermal , infectious disease , antibacterial and diseases of the Developing World malaria , TB and kinetoplastids PK Project Representative on multiple programs focusing on metabolic therapeutic disease areas Obesity and Diabetes Formulation development for biological , pharmacological , metabolic and toxicological studies in rodent and higher species dog , minipig and monkey Formulation development to drive product decisions i.e. salt selection , soft gel formulation and enteric coating for preclinical capsules Responsible for providing in vivo support for pharmacological , toxicological and pharmacokinetics preclinical studies Responsible for providing bioanalytical , in vitro and in vivo support for early discovery candidates Specialties : Project management for DMPK and Pharmacology Leader , mentor and teacher for support staff , including projects and small teams of bioanalytical and junior DMPK staff Preclinical DMPK and human dose prediction modelling including PBPK modelling GastroPlus In vivo work with rodents and dogs including brain uptake experiments , tissue distribution and metabolism studies In vitro experiments to support modelling and preclinical candidate progression Expert end user for multiple mass spectrometer platforms including Sciex and Waters Expert user on various physical characterization techniques such as DSC , TGA and PXRD Expert in formulation development for preclinical species . Technologies : DSC",
"Senior Scientist , Computational Chemistry . . Computational Chemist with a strong foundation in hard science and 8 years of experience in theoretical and computational modeling . Leverage deep learning and reinforcement learning approaches to advance drug discovery and development . Demonstrated expertise in computational modeling with 1 patent , 15 papers and 1 book chapter , serving as a first author for 10 of them from MS and PhD work . Ability to implement algorithms and proficient in Python . Equipped with 3 years of experience in writing patent applications and office actions . Selected Highlights : Provided computational chemistry support to COVID 19 drug development . Implement deep learning and reinforcement learning approaches for in house use . Developed a drug design software in Java which was patented in Taiwan Patent No . I611053 . Developed physical models that improved simulation accuracy and have been used world wide in simulation programs such as CHARMM , NAMD , GROMACS , and OpenMM . Developed data mining algorithms to retrieve complex geometric data of 145 K macromolecules and revealed new insights . Selected Machine Learning Projects conducted in 2019 : Built a convolutional neural network to automatically identify images between different bee species . Utilized ensemble method and hyperparameter tuning to predict Airbnb listing prices along with feature importances . Built a content based recommender using NLP and provided its interactive data visualization using t SNE algorithm . . Technologies :",
Head of Research Informatics . . . Technologies :,
"Senior Scientist II , Computational Biology and Bioinformatics . . Experienced Research Scientist with a demonstrated history of working in the biotechnology industry . Skilled in DNA Sequencing , Cancer Research , Life Sciences , R , and Genomics . Strong research professional with a Doctor of Philosophy Ph.D. focused in Bioinformatics from Boston University . . Technologies :",
"Scientific Director Research Informatics DPO . Key driver of integrating Nuevolution as a Center of Excellence in Amgen research Managing Research Informatics at ARC and advocating research informatics globally Pushing DNA Encoded Library technology through augmentation of AI , Machine learning and virtual screening technologies Developing new application areas of the DEL technology . PhD in Molecular Biology with focus on cross disciplinary research spanning from classical genetics to protein structure modeling . Joined Novo Nordisk Novozymes to work on protein engineering , manager of major R D project and active in identifying new business applications . Co founder of Nuevolution , inventor and leader within DNA encoded library technology Chemetics aka DEL . Worked with my excellent colleagues to develop and mature the technology from an idea to a powerful drug discovery engine with an impressive track record of delivering new drug candidates to big pharma partners and an internal pipeline . After being acqusitioned by Amgen July 2019 , I ve been a key driver in the integration of Nuevolution into Amgen Research . I ve been responsible of project scouting and evaluation ; Drug target identification within inflammation , oncology and immunoncology ; Development of new business opportunities for the application of Chemetics ; Competitive intelligence ; Alliance project management of drug discovery collaborations ; Research Informatics Bioinformatics and cheminformatics ; IT management ; Security and compliance management ; Data Protection . Versatility is my trademark ; I span across disciplines identifying the gaps of challenge and opportunitties arising in intersections between technologies , driving new advances and innovation enabling development of new medicines . Current focus is driving forward Amgen research informatics embracing areas big data analytics , machine learning and pushing innovative uses of the DEL platform for new therapeutics .. Technologies :",
Research Assistant Professor of Pharmacology . Structural neurobiology and molecular pharmacology of ion channels . A research faculty with expertise in structural biology of membrane proteins aiming to improve future medicines through biomedical research and drug development .. Technologies :,membrane proteins;structure
"Principal Scientist , Therapeutic Modalities Small Molecules Research Lead Discovery . Drug Discovery . Lead discovery program leader . Small Molecule Research . Screening , Profiling . Mechanistic cellular assays . Skilled scientist with 12 years of hands on lab experience , 5 in industry . Dedicated to personalized therapies , molecular medicine , gene and cell therapy . Broad interest in science , demonstrated success in diverse fields of research . Proven mentoring , teaching and team leadership abilities . . Effective and personable communicator . As a problem solver I enjoy finding creative solutions to challenging situations . My interest focuses on nucleic acid therapeutics that includes exploiting RNA DNA molecules both as drugs and targets , gene and cell therapy . I am passionate about technology assay development and studies on drugs MOA . I am an experienced molecular and cellular biologist with good knowledge of biochemistry . . Trained as RNA biologist , I extensively studied RNA processing and its dysregulation in disease , in particular in neurodegeneration . In industrial settings , I dealt with diverse therapeutic modalities , including small molecule inhibitors , engineered antibodies and mRNA based vaccines in the context of cancer immunology . . I value diversity , collaboration and the possibility to work in a cross functional environment . This led me to establish numerous alliances and productive interdisciplinary partnerships . I feel fortunate to have had the possibility to mentor several students and to lead a cross functional team for a technology development effort . . I am currently part of the Lead Discovery Team in Roche focusing on Small Molecule Therapeutics . . Technologies :",antibodies;biologics;nucleic acids;small molecules;engineering;screening
"Doctoral Researcher . . I am a computational ecologist with broad interests throughout the natural world . My current research focuses on spider web morphology and scaling relationships throughout the arachnid world . Furthermore as a previous graphic design student and current musician i am fascinated by bioacoustics and sensory processing throughout nature . From thermal imaging of social insects and nematode worm bioacoustics through to computational modelling of spider web scaling , in the lab and the field , innovative research at the cutting edge of technology and knowledge is always my aim .. Technologies :",
"Production Scientist . 1 Enzymes Monoclonal Antibodies purification in regulated environment following GDP Good Documentation Practices . 1.1 Development of Chromatographic Strategies for purification of biomolecules . 1.2 Handling and Mantenance of Chromatography columns . 1.3 Optimization Scaling up 1 g to 100 g final purified product . 2 Expertise with kta avant pilot process . 2.1 Automation development of totally automated or hybrid automated manual control methods to achieve faster and consistent chromatographic separations . 3 Technical drawing of highly detailed schemes describing how to handle complex equipment and describing processes . . Currently works at Bioline GmbH as Production Scientist . Mastered skills : 1 Chromatography , strong with kta Purifier , Avant and Pilot 2 Cloning , protein engineering , production purification , . Technologies :",antibodies;proteins;expression
"Senior Scientist . . Senior Scientist at Orthros Medical , a scale up biotech developing and manufacturing engineered antibody fragments , VHH , in yeast . With scientific experience developed through my PhD background in pathogenic Candida spp . and post doctoral studies in yeast biology and clinical diagnostics , I am now working on VHH optimization and manufacturing in yeast . As a senior scientist I am overseeing development strategy and process optimization as well as project management and laboratory execution . In addition , I am acting as an R D point of contact for our customers . . Technologies :",antibodies;engineering
"Assistant Professor . . Membrane proteins represent intriguing objects for investigation , though they remained a terra incognita of the structural biology for many decades . Novel methods , such as atomic force microscopy and high resolution fluorescence microscopy allow for spectacular insights on these systems . I am interested in studying diverse dynamic biological interactions down to single molecule level , with a primary focus on membrane protein systems . Specialties : Theoretical and practical background in protein research Broad expertise in research methods Team supervision and support . Technologies :",membrane proteins;structure
"Scientist . Research Discovery , PCO Drug Metabolism and Pharmacokinetics Working in a collaborative environment with biologists , medicinal chemists , and DMPK scientists , to support small molecule drug discovery programs in the areas of oncology , inflammation , immunology , fibrosis , and neglected diseases . Provide extensive knowledge of ADME properties and applications to projects by assisting with discovery project representation , study coordination , ADME data interpretation and presentation of scientific findings Contributing to experiment design and resolving project barriers with collaboration with pharmacology and toxicology departments Generating and executing protocols and technical reports with precision Aiding management on improving efficiency and productivity within the group by training junior associates , and developing assays . . Technologies :",
"Scientist II . . I am a research Scientist with over 10nyears of experience in the field of structural biology and drug development . In addition , I have over ten years of experience in molecular biology and recombinant DNA work , assay development , cell biology and biochemistry techniques and in depth knowledge and skills in protein expression and purification , Protein crystallography and other biophysical techniques . I received my Ph.D. in Structural Biology from the Jawaharlal Nehru University , India and then went on to do postdoctoral studies at Washington University in St. Louis School of Medicine in the biochemistry department . Expertise : Protein Expression bacterial , insect and mammalian cell Molecular Biology Protein Engineering Protein purification Biochemical and Biophysical Characterization of Proteins Protein conjugation with Fluorescence probe including , Amine coupling , maleimide and sortase reaction Protein protein , Protein DNA and protein small molecule interaction Bioinformatics , Docking and Protein Engineering Protein Crystallization and X ray Crystallography Small angle X ray scattering Core competencies : Cell culture bacterial , insect and mammalian PCR , DNA cloning , site directed mutagenesis FPLC Biorad NGC , HPLC Dionex , AKTA , affinity , ion exchange and size exclusion chromatography Antibody purification Mass spec LC MS , GEE labelling footprinting and LC MS MS , SPR , ITC , Thermal melt assay , radioligand binding , HTS Crystallization , structure solution using Molecular replacement and SAD methods UV visible , Circular dichroism and fluorescence spectroscopy Bioinformatics approach for protein engineering Cell based assays Liposome preparation FRET and fluorescence based High throughput assay development R programming , Python programming , Tableau for data visualization and analysis . Technologies : Xray;CryoEM;ITC;SPR;AUC;CD;FRET",proteins;characterization;expression;interaction;structure
"Scientist , Statistical Genetics . . . Technologies :",
"Research Intern . Department of Actives and Formulations Protein Stability . I am a honest , hardworking and ambitious student who aspires to be a Scientist in the field of Bio pharmaceuticals . My objective is to be associated with an institution that gives me a platform to enhance my knowledge and skills in accordance with the recent trends in the field of research and development . I wish to provide help and service to the people with the knowledge and experience I have and would gain in my academic career . . Technologies :",proteins;stability
Senior Research Fellow . . Computational Chemistry and Biophysics . Technologies :,
"Adjunct Professor . I teach a variety of courses primarily involving Data Science to undergraduate students . . Computational Neuroscientist focusing on designing and developing applications that utilize affective inputs such as emotions , pupillometry , for neuropsychological investigations , HCI , BCI , Robotics , Recommender Systems , and novel Biometric solutions . I have 20 years in this domain , as an academic and as a developer utilizing state of the art machine learning algorithms reinforcement learning , deep learning , recurrent NN , rule based systems such as rough sets and fuzzy sets , I have published over 170 scientific papers and 3 books on a variety of topics ranging from basic data classification techniques to deploying real world neuropsychological applications for the sentiment analysis , locked In subjects BCI , and user specific biometric person identification solutions . I also have a significant amount of AI machine learning experience spanning more than 30 years . I have utilized neural networks , GAs , L Systems , AIS , swarm technologies , as well as more traditional machine learning algorithms , such as LVQ , Tree based methods , clustering , gene sequencing strategies , computer vision analysis of medical imaging datasets , amongst a host of other technologies . More recently , I have focused on deep learning within the document imaging domain , focusing on mortgage documents 4 years .. Technologies :",
"Senior Scientist at BioMedicine Design Pfizer . Bio therapeutic discovery . o Antibody engineering . . o Use of display technologies , phage and yeast , for selection campaigns . o Flow cytometry and single cell sorting . . o Development and optimization of selection methods . o Analysis of antibody properties using polyreactivity assay , aSEC , SDS PAGE , ELISA . . o Expression and purification of antibodies . o Molecular biology , cloning , and vector engineering and design . . . Technologies :",antibodies;characterization;engineering;expression
Associate Principal Scientist Discovery Sciences Medicinal Chemist . . . Technologies :,
"Researcher . GC MS , LC MS MS , ICP OES , XRF . . Analytical chemist , neurochemist , biochemist , electrochemist . Working at Swerea IVF . Postdoc in marine chemical ecology . Isolation and determination of lipid structures of new , unknown signal substances from copepods with LCMS , GCMS and NMR . Doctoral thesis work included method development of separation , electrochemical detection and analysis of neurotransmitters . Also focused on pharmacological aspects of drugs associated with neurotransmitter protein transporters . Used the in vivo model Drosophila melanogaster . Master of science thesis work included protein purification , crystallisation and catalytic activity assay of membrane proteins .. Technologies : NMR",membrane proteins;stability
"Researcher . Analysis of deep mutational scanning data beta lactamase using variational autoencoder Writing original research manuscript providing new insights into the evolution of multidrug resistance in bacteria Writing in collaboration : method for microbial GWAS using Probabilistic Soft Logic Supervision of team developing microbial GWAS methods for detection of epistatic interactions Supervision of team detecting mutation signatures in HIV using a technique for blind source separation . Inspired computational evolutionary biologist with a track record of success on high profile projects and with extensive experience in bioinformatics algorithm development and statistical analysis of large genomics data . Also enjoys teaching , mentoring , recruiting and supervising talent .. Technologies :",
Scientific Researcher . Developing in silico methods for drug repurposing Writing grant proposals Coordinating WP1 in silico trial prediction and WP2 pre clinical validation of predictions collaboration REPO TRIAL H2020 project . . Technologies :,small molecules;developing
"Principal Scientist . Downstream Process Development . KEY ACHIEVEMENTS Established the strategy towards phase III and registration for virus clearance , including process challenge of virus clearance . The strategy was endorsed by several authorities , among others Paul Ehrlich Institute and FDA Established the strategy for Process Challenge of the Purification Process for a late stage product . The strategy was endorsed by the authorities menthioned above . Development of a process for preparation of material for a generic HCP assay , valid for registration . The prepared material obtained a high coverage of HCP in the unprocessed harvest . Significant contribution to the development of existing mAb platforms with respect to virus clearance Development and implementation of a microfiltration step for harvest . Responsible for experiments from lab scale via pilot scale to production scale . Work presented at GE life science day 2010 and implemented in the final process for market . Considerable improvement of the FVII a process in production by experiments concerning the mechanisms involved in steering the activation degradation of FVII a in solution and during the chromatographic process . Validation of UV treatment of serum in order to clear potential virus . Significant contribution to a major upgrade of LIMS in the QC laboratory , including automatic calculation of results . Technologies :",
"Senior Scientist , Data Science . . Computational Biologist Data Scientist : 12 6 years industry 6 years academia years experience as data science lead on multi disciplinary project teams within and without the organization ; Designed 100 in vitro , 40 pre clinical experiments and 3 clinical studies ; screening , lead prioritization , exploration of MoA and lead optimization . Created multiple innovative computational statistical solutions for leveraging high dimensional multivariate and univariate datasets generated within and without the organization that led to more efficient screening , lead identification and generation of value for the company . Encouraged and educated non statistically trained colleagues in the research organization to think statistically while planning studies experiments and communicate complex multivariate datasets more effectively . Relevant technical skills Bioinformatics and statistical analysis of mutivariate omics data analysis : Compositional data 16s , shallow and deep shotgun sequencing based taxonomy and functional data ; RNASeq based metatranscriptomics , transcriptomics datasets , Affymetrix chips based gene expression datasets ; Metabolomics untargeted metabolomics of clinical samples , GC MS , LC MS targeted metabolites like short chain fatty acids and bile acids from clinical and ex vivo samples ; Immunoprofiling Luminex panel , dentritic cell profiling and TEER data from ex vivo samples ; Colorimetric assay data primary bile acids , ammonia , trimethylamine tma and optical density od600 data Next generation sequencing data NGS analysis taxonomy , functional genomics , transcriptomics , metatranscriptomics datasets metaphlan2 , humann2 , SAMtools , BURST , DIAMOND , Bowtie , Tophat ; downstream analysis Cufflinks , DESeq , EdgeR , Newbler etc . Processing of 2D NMR and permethylation linkage analysis data for structural profiling . Gitlab version controlled development and modification of machine learning methods algorithms . Data visualization and sharing using the R platform ggplot , R markdown , plotly , R shiny , Igraph , tableau , visualizing and analyzing complex biological networks using JUNG and Cytoscape platforms of Java . AWS services aws cli , EC2 linux AMIs , Nexflow workflows Design , analysis and implementation of high performance serial and parallel computer algorithms using MPI and OpenMP in Java platform for optimal use of AMP Optron Cluster . Data Analysis Platforms : R and MATLAB , familiarity with Python Programming Languages : Java C , shell scripting languages Perl , awk , grep and sed . Technologies : NMR",
Senior Staff Computational Biologist . . . Technologies :,
"Senior Computational Biologist . . Versatile Bioinformatician and Data Scientist with 15 years experience deriving insights from multidimensional data using statistical and machine learning methods . Recent work entails a hands on approach through the full data lifecycle from raw instrument data collection to data munging , analysis , visualization and results write up Core skill sets : Hypothesis testing methods and regression models Machine learning for dimension reduction , clustering , and applying classification prediction algorithms Publication quality data visualization using ggplot and ploty for interactive plots and proficient in building apps in R Shiny Finding , assessing , and applying new tools and techniques to address specialized data or research study requirements . Managing core system and process elements of an applied bioinformatics lab , including database and web server administration , creation of data shares and pipelines , instrument interface development and configuration , and general data management . Applying my analytical expertise in an inter disciplinary environment that requires both guiding and learning from my collaborators , which include clinicians , investigators , and researchers . Tech used : R , R Shiny , Python , SQL , JavaScript and Bash . Technologies :",
"Director of AI research . We are building a research group working in the frontiers of deep learning . Machine learning researcher , with expertise in machine perception and computational biology . Current focus on reasoning and perception image understanding . Leading teams in academia and industry , I gained experience with the full research to product life cycle , from cultivating exploratory ideas , through testing prototypes , to shipping products . Expertise : Machine learning , Deep learning , Probabilistic models , Information theory , Computer vision , Transcriptomics , Computational Neuroscience , Vision and Language . . Technologies :",
"PHD Student . . PhD student in Biochemistry , studying ion channels with cryo EM and electrophysiology . Technologies : CryoEM",membrane proteins;structure
"Research Scientist . Immunology , immuno oncology , the tumor microenvironment , endoplasmic reticulum stress biology , and drug development . . Self motivated molecular and cellular biologist , with 10 plus years of in vivo pharmacology experience from various preclinical species at the pharmaceutical environments , PD assays , PK PD relationships , POC studies , characterization of various animal models including cardio metabolic , thrombosis and immuno oncology models and 20 plus years of in vitro experience of molecular , biochemical and protein techniques , cell culture , immunoassays , and statistical analyses to elucidate pathways underlying the pathophysiology of cardio metabolic diseases NAFLD , Type 2 Diabetes ; Heart failure and thrombosis ; immunology , immuno oncology , the tumor microenvironment and endoplasmic reticulum stress biology . Extremely knowledgeable in overall basic laboratory techniques including high throughput screens , ELISA , Cell cultures including primary cell preparation and culture , transient and stable transfection ; DNA and RNA preparation , molecular cloning , PCR RT PCR ; recombinant protein expression and purification ; FPLC instrumentation , antibody purification , Western blotting , Immunofluorescence , Immunohistochemical staining and multi color FACS . Effectively communicated scientific concepts to varying backgrounds groups , managed teams with diverse skill sets and foster agile approach to effectively monitor progress and adjust approaches strategically to ensure success of the project . Active promoter of productive collaborative teams that have generated high quality data .. Technologies :",antibodies;proteins
"Research Fellow . Division of Complex Drug Analysis : Characterized nanomaterials based drugs to investigate the quality of abbreviated new drug applications ANDAs and reference listed drug RLD using cryo SEM , and Raman analyses . Developed protocols for sample preparation via cryofixation using high pressure freezing and freeze substitution techniques . Collaborated with different research groups at FDA to assist in physiochemical characterization of drugs including liposomal based albumin nanoparticle bound paclitaxel , Cyclosporin , Bupivacaine , Degarelix , Tretinoin . . Experienced professional with a Ph.D. from University of Minnesota and demonstrated success to deliver scientific research skills with innovation through various intellectual properties and a start up company . 7 years of experience in bio nanotechnology including development of bioassay techniques , wet chemical synthesis of nanoparticles , and physiochemical characterization techniques of nanomaterial nanomedicines . Have been trained on wide range of analytical techniques including SEM , cryo electron microscopy , TEM , DLS , FTIR , Raman , Atomic absorption and IR spectroscopy , HPLC and other chromatographic methods . Proficient in Immunochemical ELISA , Western blot and Immunofluorescence microscopy and molecular techniques PCR , cloning and gene expression and hold two degrees in Biochemistry . Have experience with project management including proficient budgeting , assessing resource constraints and hiring appropriate candidates . Enjoys interacting with multicultural people , hiking and outdoor activities . Aspire to work in industry as an R D scientist , consultant and project manager .. Technologies : CryoEM;SLS DLS",carriers;characterization
"Manager Production Support Validation . . Specialties : Downstream process development Downstream manufacturing Refolding Recovery by aqueous two phase partitioning Separation of intracellular membranes and purification of membrane proteins Target protein production for high throughput screening and structural analysis Protein expression , purification and characterization Yeast and plant glycolysis Plant respiration . Technologies :",membrane proteins;characterization;expression
"Postdoctoral Scholar . . Data scientist with more than 10 years of experience in the fields of structural bioinformatics , molecular modeling , data science , and cryo electron microscopy cryo EM . Structural Bioinformatics and Molecular modeling Developed five methods and analysis workflows for protein structure modeling and peptide design . Modeled more than 10 protein structures and complexes using homology modeling MODELLER , loop modeling and protein protein docking of different biomolecules with Integrative Modeling Platform IMP https : integrativemodeling.org and AlphaFold2 to characterize protein protein interactions . Determined three large macromolecular complex structures by integrating information from experiments such as cryo EM and chemical cross linking using generative modeling techniques such as Bayesian inference . Performed protein sequence and structure analysis with multiple structural bioinformatics tools and databases . Predicted protein structures de novo using tools such as Rosetta and understanding of protein design methods . Programming and Data Science Developed multiple software tools using Python 8000 lines and libraries such as Biopython , Pandas and NumPy . Contributed to the code and maintenance of the Integrative modeling platform IMP software which is a molecular modeling package for modeling large macromolecular assemblies by integrating information from experiments and physical theories . Utilized version control systems such as Git and Unix based shell scripting to develop and maintain software . Designed workflow for handling large cryo EM image datasets for classification and 3D reconstructions . Performed computing tasks using high performance computing environments such as large HPC clusters . Applied machine learning tools such as PyTorch and Scikit learn to solve problems in structural biology . Communication and Project management Worked in multiple interdisciplinary teams to meet project goals remotely and independently . Communicated research findings through six publications and presentations at international conferences . Managed multiple research projects mentoring junior scientists and led teams at hackathons winning prizes .. Technologies : CryoEM",
"Senior Principal Scientist . . In the past 15 years , I have built computational platforms and trained predictive models to solve data centric problems in RNA biology , single cell genomics , molecular genetics , precision medicine , immuno oncology , and drug development for rare diseases . I have fulfilled technical lead and strategic oversight support roles in research , development , and clinical functions during the past 7 years in three early stage startups . I strongly believe that my scientific versatility and servant leadership style help me empower small collaborative teams to achieve well planned objectives and reach extraordinary goals . I have led teams through two stages of drug development target prioritization for IND enabling studies and target patient stratification in natural history studies . I am excited to increase the speed and success rate of modern bio pharma med projects as they fully enter the era of digital science . Specialties : computational molecular biology , bioinformatics , machine learning , predictive models of biology , large scale genomics , rare disease , precision medicine , single cell transcriptomics , early stage drug design and development , off target effects , lead optimization , experiment design , assay development , reproducibility .. Technologies :",
"Director of Manufacturing Sciences and Technology GTO . Provision of leadership to a team of Scientists with responsibility for providing scientific direction and support for the manufacture of commercial products . The MSAT and Product Technical Leads provide end to end technical support to internal manufacturing sites and Contract Manufacturing Organisations CMOs used by Alexion for production of commercial products , including support of Technology Transfers , on going process investigations , changes , validation , and process improvement initiatives . . Responsible for overseeing MSAT process and analytical activities to support commercial manufacturing with small scale lab models on behalf of Alexion by partnering with CLOs . . Maintain Technical Risk Register and mitigate same . Member of GTO leadership team , and BPOG L2 for DS Phorum . . An interest in science and manufacturing , led to a career in bio pharmaceuticals . A journey that has included start up of multiple new internal external manufacturing plants and associated technology transfer of development , clinical , commercial , and in licensed manufacturing processes through to successful regulatory filing and licensure . A key driver for me is knowing that the work I undertake daily has a positive impact on our patients lives , particularly ultra rare and rare diseases to deliver life changing medicines at Alexion . . I ve been fortunate to have had the opportunity to experience roles of increasing responsibility across small , medium and large sized companies , at small through to large scale cell culture and protein oligo purification processes for enzyme and hormone replacements , including monoclonal antibody therapies , in Manufacturing , Technical , Quality and SME roles . . Improvement of processes and understanding in development , technology transfer and post launch optimisation of commercial processes while maintaining a foundation of manufacturability has been an area of interest . . In more recent years , building high performing teams , providing leadership , and finding solutions and strategies to difficult problems have been a key area , with no challenge being too small to take on . . Technologies :",biologics;expression
"Researcher in Digital Phenotyping . . Clinical Computational Phenotyping . Applying Computer Vision approaches to extracting clinically relevant information from photographs . Computational biology , inferring causative variants in next gen sequencing data . Previous experience : Detection and characterisation of transposable elements . Research within the topic of neurovirology . Focus on expression quantification and expression profiling of human endogenous retroviruses , this in particular pertaining to expression in diseases such as schizophrenia . Assay development of qPCR and melting temperature analysis . Computational biology techniques , next generation sequencing data , method development , transposable elements , neuroscience , virology .. Technologies :",
"Scientist III . . I have over a decade of experience in molecular virology with 7 years of experience in antibody virus interactions . My broad skills set includes cell molecular biology , assay development , clinical collaborations , library screening , NextGen sequencing , and data analysis using Python . I am interested in applying my experience developing new diagnostic tools , vaccination strategies , or antibody therapeutics and am open to many other opportunities .. Technologies :",antibodies;interaction
"Senior Scientist . Lead early discovery projects on respiratory viral targets . Scientist with extensive experience in small molecule drug discovery ; developing assay technologies and elucidating compound mode of action in oncology and virology disease areas . Accomplishments range from streamlining assay processes and developing proprietary technology platforms to effectively presenting complex material tailored to a broad range of audiences in a clear , concise and persuasive manner . Specialties : Expertise includes in vitro enzymatic assay development , steady state and pre steady state kinetics , liquid handling robotics , and MTS compound screening and profiling .. Technologies :",small molecules;screening
"Assistant Ing nieur . Laboratoire CiTCoM : Cibles Th rapeutiques et Conception du M dicament UMR 8038 CNRS Universit Paris Cit ; Nicolas LEULLIOT ; Equipe : Signalisation et transport membranaire responsable : Isabelle BROUTIN . Contexte : Mon quipe est sp cialis e dans l tude structurale des prot ines membranaires impliqu es dans la r sistance aux antibiotiques . Elle s int resse plus particuli rement l efflux actif des antibiotiques via quatre pompes tripartites de la bact rie Gram n gatif Pseudomonas aeruginosa . Nous menons ces recherches par des approches compl mentaires associant la biologie structurale cristallographie , SAXS , Cryo EM de l analyse fonctionnelle in cellulo . Missions : Production et purification des macromol cules biologiques prot ines membranaires essentiellement tudi es dans l ' quipe en vue de leur tude fonctionnelle et structurale . Utilisation de protocoles optimis s et participation la mise au point de la production de nouvelles prot ines recombinantes par biologie mol culaire mutag n se dirig e . Mise en place au laboratoire de la reconstitution des prot ines membranaires en nanodisques Pr paration d ' chantillons par coloration n gative pour la microscopie lectronique par transmission et enregistrement des images . R daction de protocoles et gestion des stocks de mat riels biologiques , des produits chimiques et des consommables . Formation des nouveaux utilisateurs , v rification du bon fonctionnement des appareils , planification des maintenances pour les appareils do nt j ai la responsabilit . Implication dans le comit technique du laboratoire Gestion de la r vision des Pipetmans l chelle de la facult . Formation des stagiaires de l ' quipe . Formations : Atelier INSERM 267 Formation th orique : Prot ines membranaires en syst mes reconstitu s : des derni res avanc es en recherche fondamentale aux applications th rapeutiques mars 2022 ; Bordeaux . Congr s : GDR APPICOM 2021 Novembre 2021 , Lyon . . . Technologies : CryoEM",membrane proteins;proteins;expression;structure
"Charg e de Recherche CNRS . . Biochemist and structural biologist with expertise in protein engineering , protein interactions , crystallography and cryo electron microscopy . Skills in molecular biology , protein expression and purification , assay development , protein protein and protein nucleic acid interaction analyses , X ray crystallography , cryo electron microscopy . Team oriented , capable of managing and developing projects with excellent communication abilities . Guided and advised several graduate student and post docs .. Technologies : Xray;CryoEM",nucleic acids;proteins;engineering;interaction;structure
"Senior Bioinformatician . Drug discovery , peptide analysis , NGS , workflow automation , decision support . Population genetics , bioinformatics , statistics , programming , omics , web technologies , information management systems , web design . Technologies :",
Research Associate . New Antibody Product Research Department . . Technologies :,antibodies;developing
"Drug Product Design and Development Scientist . COVID 19 mRNA vaccine formulation and process development Seasonal Flu mRNA vaccine formulation and process development . I am a nanotech scientist who combines nanomedical aptitude with mathematics and computer science to drive breakthrough understanding of cancer development through computational genomics . By advancing computational methods for early detection of oncogenesis and illuminating the complex cancer mechanisms I aim to find critical vulnerabilities and drug targets . Previously I developed innovative drug designs for the fields of oncology , immunology and rare diseases . Pfizer BTxPS 2020 Impact Award Winner for Outstanding Contributions to the COVID 19 vaccine . Patents holder for 2 novel therapeutics that I helped to formulate .. Technologies :",biologics;formulation
". . Driven by passion for protein chemistry and analytical techniques such as NMR , MS , HPLC , XRC and Cryo EM .. Technologies : CryoEM;NMR",proteins;structure
"Senior Staff Scientist . . I 'm currently a senior scientist in Professor Tony Kossiakoff 's lab at the University of Chicago . My research is focused on dissecting the structure function relationship of membrane proteins using cryo electron microscopy and synthetic antigen binders sABs , which I generate using phage display libraries and in vitro selections . I lead a team of young scientists , with the goals of determining structures of proteins involved in bacterial homeostasis and pathogenesis and providing sAB reagents to the structural biology community . Our efforts here have led and contributed to over a dozen peer reviewed publications . Read more about our work here : https : kosslab.uchicago.edu . Technologies : CryoEM",membrane proteins;structure
"Machine Learning Scientist . . I develop statistical machine learning methods for the analysis of biomedical signals , with the goal of improving patient diagnosis and treatment through translational research . I am passionate about data , algorithms , mathematical modeling and their applications in computational biology .. Technologies :",
Oncology Bioinformatician . . . Technologies :,
"Alexander von Humboldt Research Fellow . . My research activity regarding the design and synthesis of novel anticancer agents with various mechanism of actions such as inhibition of kinases , organometallic enzymes as carbonic anhydrases and histone deacetylases in addition to their degradation using PROTACs .. Technologies :",molecular glues;small molecules;developing
PhD Student Institute for Molecular Biology and Biophysics Prof. Nenad Ban . Boehringer Ingelheim Fonds PhD fellowship 2019 2021 PhD Program Biomolecular Structure and Mechanism Life Science Zurich Graduate School Topic : Structural investigations of eukaryotic ribosomal complexes with cryo electron microscopy . On the lookout for fascinating opportunities in the life science industry consulting shaping my personal growth and career An open minded and solution oriented PhD candidate in structural biology with advanced project management skills Passionate about open science and empowering early career researchers . Technologies : CryoEM,proteins;structure
"PhD student in Medicinal Chemistry and Teaching Assistant . PROTAC design and synthesis to explore dysfunction of the Ubiquitin Proteasome System UPS in cancer , group of Prof. L. Scapozza , Biochemistry Chemistry , Pharmaceutical Sciences . I am a Ph.D. student in Medicinal Chemistry with a background in Pharmaceutical Sciences . Passionate about medicinal chemistry and chemical biology , I like contributing to scientific research with creative and innovative solutions in potential areas of unmet medical needs .. Technologies :",molecular glues;developing
"Principal Scientist Computational Biology . . I combine big data , machine learning and artificial intelligence to create sublime data products while simultaneously protecting data privacy . I lead organizations using the principles of science .. Technologies :",
Computational Biologist . . . Technologies :,
"Senior Research Associate . . I 'm a Senior Research Associate at the Center for Computational Biomedicine in the Harvard Medical School . My research interests revolve around knowledge representation and reasoning . I 'm interested in the application of ontologies to improve information accuracy , management , and dissemination , and to facilitate knowledge discovery .. Technologies :",
Bioinformatics Data Scientist II . . . Technologies :,
"Research Computing Consultant . . My research background is in computer science and microbiology , with extensive expertise in large scale genomic data . . Technologies :",
"Cryo EM expert . . Languages : French : Native speaker . English : Perfectly fluent oral and written . German : Spoken A2 B1 level , Writing A2 B1 level , reading A2 B1 level Deutschkurse LMU . Laboratory skills Biochemical : In vitro : Nucleic acid purification , modification and structure analysis . Detection methods Northern and Western blotting . Protein over expression and purification in native and denaturing conditions globular and membranes protein via HPLC , protein refolding and activity assays . Reconstitution and purification of ribonucleic complexes ribosome and mRNP complexes . Labelling of protein and nucleic acids radioactivity , fluorescence . Cell free expression system prokaryotic and eukaryotic . Chemical cross linking in vivo or in vitro . Immuno precipitation and purification procedure . Crystallization procedures protein , RNA and complexes . In vivo : Microbiology : working and cloning in Gram negative Gram positive bacteria , complementation assays , genomic tagging and gene knockout . Eukaryotic cell : yeast gene tagging and complex pull out . Cryo EM : Negative stain uranyl acetate . Checking negative stain on FEI Morgani transmission electron microscope . Cryo grid preparation , grid clipping . Data collection on Talos Arctica with EPU counting mode linear mode and Titan Krios Data collection on Titan Krios at CETEIC cryo EM facility , Brno Czech Republic Data collection on Titan Krios at the CSSB 3D structure reconstruction and modelling : Cryo EM 3D structure reconstruction : Single particle analysis : Spider , Relion , FreeAlign , ResMap , Sphire . 3D structure building : de novo RNA 3D structure modelling based on both sequences covariation and 2D structure probing constrain Assemble , Coot , Chimera . de novo 3D structure building using density maps Coot , Chimera , Phenix , Refmac . Crystallographic programs CCP4 . 3D structure analysis with molecular graphics software : PyMol , Coot , Chimera , ChimeraX. Informatics : Programming skills : Sequential programming language FORTRAN , shell scripting . Object oriented programming language C , perl , Java , Python . Statistic program R . Operating system Linux , MacOS , Windows and cluster knowledge . . Technologies : CryoEM",nucleic acids;proteins;structure
Post Baccalaureate Fellow . Computational biology researcher . hi . Technologies :,
". . My main contribution to the field of electron microscopy has been the development of a support foil with holes of pre defined size , shape and arrangement , QUANTIFOIL together with Eugen Ermantraut . In general , my research was methodologically as well as biologically oriented and was focused on biomacromolecular complexes and also on cell biological systems . Specimen preparation techniques applied included negative staining , shadowing , vitrification and freeze drying in the one field and high pressure freezing , freeze substitution , embedding and sectioning in the other . I carried out three dimensional reconstructions of single particles via angular reconstitution and via random conical tilting , and of semi thin sections by tomography . I developed a correlative approach to fluorescent live cell imaging and electron microscopy . At the European Molecular Biology Laboratory EMBL in Heidelberg , I oversaw a STEM facility during the second half of the eighties and the beginning of the nineties , and carried out mass determinations in collaboration with several colleagues both inside and outside the EMBL . I contributed to establishing an infrastructure for high resolution cryo EM in two labs . My last publication is about the appearance of the power spectrum when the specimens thickness exceeds the microscope 's depth of field and about the information that can be retrieved from such a power spectrum with respect to the objective lens defocus and the specimen thickness .. Technologies : CryoEM",
"Senior Scientist , Protein Biochemistry and Biophysics . Support a broad range of drug discovery and development efforts that include screening and lead discovery , and detailed studies of ligand protein interactions ; Support drug lead discovery , optimization , and development through the application of protein biochemistry and biophysics ; Support the discovery and development of therapeutic targets ; Drive fit for purpose construct design , expression analyses , and purification protocol development to produce high quality protein reagents for screening and biophysics ; Responsible for characterization of protein using biochemical and biophysical methodologies to confirm folding , function , and binding competencies with know ligands and tool molecules ; Expert in construct design , protein expression using diverse expression systems mammalian , insect , and bacterial , and protein purification ; Proficiency in analytical techniques LC MS , DLS , SEC MALS , thermal shift assay to study protein folding and solution behavior ; Proficiency in production of challenging protein targets integral membrane proteins , intrinsically disordered proteins , multi protein complexes for biochemistry and biophysics ; Experience with biochemical and biophysical characterization methods enzymology , SPR , spectroscopy , and calorimetry to guide construct design ; Experience with structural techniques such as BioNMR and X ray crystallography ; Collaborative interactions with other members of the global , cross functional department ; Cooperative and collaborative use of internal expertise and resources ; Excellent organizational , analytical , and communication skills ; . I m a highly motivated and energetic research scientist with 14 years of experience in project management , team work , and creative problem solving skills with expertise in cancer research , target identification , and drug discovery . I 'm fascinated by how proteins function . Unlocking their function can expand our comprehension of health and disease states , leading to new therapeutic strategies and drugs , ultimately helping patients and making a difference in people s lives . That s what drives my passion . I enjoy learning and like to interact with people in a collaborative way . I 've managed projects in epilepsy and neurodegenerative diseases , leukemia , multiple myeloma , and prostate cancer . I 've worked with more than 40 different target proteins , excluding variants , for structural determination , protein protein interaction PPI characterization , biochemical and enzymatic assay development , and biophysical studies . Some of those targets were transcription factors , enzymes , scaffolding proteins , and oncogenic targets . Disclaimer All articles and news posted in my Linkedin profile are my own personal interests and not of my employer . They are intended to inform the general public and my network . Opinions of course are my own and not the views of my employer .. Technologies : Xray;ITC;SLS DLS;SPR;CD;NMR",idps;membrane proteins;proteins;small molecules;characterization;interaction;screening;stability;structure
"Director of Operations , Stanford cryoEM center . I manage Stanford cryoEM service center staff and equipment A TFS Glacios , 2 TFS Krios , a fun little Morgagni , and associated prep supplies . I have managed the installation of the Glacios and we are currently installing an Aquilos FIBSEM . . . Technologies :",
"Bioinformatics Scientist . . My research has been focused on investigating semantic attribute approaches to improve machine learning models of patient prognosis and drug sensitivity . Spinoffs of this work include a large scale model selection training deployment framework and web applications to apply suites of hundreds of models to uploaded gene expression data . Previously , I helped kick start the informatics group at Baylor College of Medicine Human Genome Sequencing Center HGSC during the Human Genome Project ramp up . At the HGSC I developed significant parts of the Atlas Genome Assembly Suite , machine learning based QA software , GUI assembly visualization tools , a fast read mapping tool , and a rule based DNA sequence analysis pipeline . Before my segue into bioinformatics I worked at an electrical engineering consulting firm where I designed hardware and software for embedded digital signal processing systems . . Technologies :",
"Principal Scientist 1 . Provide separation science support for the drug discovery medicinal chemistry team at BMS in Lawrenceville , NJ . Use HPLC and SFC for achiral chiral small molecule analysis and separations . Shimadzu Waters Agilent instruments . Lab manager . Small molecule purification , HPLC LCMS SFC , analytical chemistry ; medicinal chemistry ; DNA encoded chemical libraries DEL . Technologies :",small molecules
"Computational Biologist I . . I am interested in generating and integrating next generation sequencing NGS data so that we can further understand the mechanisms of transcriptional and epigenomic regulation on a cellular level . My doctoral research focused on developing approaches to understanding how stresses in particular , viral infection can modulate and interfere with gene regulation . In addition to writing software to analyze these data , I also performed experiments to validate my computationally derived hypotheses . Currently , I utilize these skills to work in research and development of pharmaceuticals that target epigenetic regulation in order to treat rare genetic diseases . I develop pipelines and perform analysis on a variety of projects for a suite of diseases in a variety of diseases and tissues with the aim of discovering and validating drug targets in a rigorous and reproducible manner .. Technologies :",
Senior Scientist . Drug discovery and platform : protein expression purification biophysical binding HTS cryo EM and crystallography DEL and conformation selective binding screens integrative tractability workflows Major pipeline contributions : Human glycogen synthase glycogenin complex structures cryo EM with inhibitors for structure based design ; first author manuscript in revisions Expression to structure workflow leading to 20 small molecule inhibitor bound structures of a membrane protein complex cryo EM that drove 1000x potency increases DEL screen against a membrane protein in nanodiscs ; new molecules and key analogs . I am a protein biochemist with 8 years research experience working on challenging targets such as membrane proteins and oligomeric complexes . My current focus is the development and implementation of technologies to enable and accelerate drug discovery . Areas of expertise : Protein structure and structure based drug design Small molecule screening and biophysical characterization Protein engineering and combinatorial binding screens yeast phage display and DEL Mentorship and communication . Technologies : CryoEM,proteins;small molecules;characterization;engineering;expression;screening;structure
"Research Associate II . . During my undergraduate career at University of Texas at Austin I was involved with lab work focusing on combining wet lab with the computer lab . As a recent Masters graduate from Taipei Medical University , I advanced my learning on virology to work on Coronaviruses , Flaviviruses , Picornaviruses , Retroviruses , and Rhabdoviruses . I 've done molecular docking of ligands onto enzymes and viral glycoproteins with experience in PyMol , UCSF Chimera , and Autodock Vina . Currently , I 'm a research technician at Scripps Research Mravic Lab looking at HIV and the mystery of its transmembrane regions . Aside from the education field I also worked at a Biomedical Tech start up called Reliant Immune Diagnostics and was a finalist for a queer innovation start up competition in Taiwan . I also earned a B.S. in Radio Television Film writing scripts , shooting short films , and learning how to direct and produce . Through this medium I hope to continue to create short films containing humor and drama about the queer experience as well as the Asian American experience . My short films , and Little Swimmers , is currently out , and I 'm currently working on a webseries called Existential Crisis Club . I am also a spoken word poet and have performed at Silk Club ATX in Austin , Texas , and The Salon in Taipei , Taiwan .. Technologies :",
"Associate Principal Scientist . In Vitro biochemical assays , PROTACs , Project Lead . . A dedicated scientist with a strong passion in early drug discovery . Strong expertise within target production , assay development and screening . Have worked with many different drug discovery projects from Hit Finding to Lead Generation as a core team member or discipline lead .. Technologies :",molecular glues;small molecules;screening
"Subject Matter Expert Microfluidics . . I am passionate about developing disruptive solutions that improve life quality . My focus has been on the development of microfluidic technologies and its applications for life sciences , drug development , pharmaceutical and enzyme development . Key words : Biotechnology , Droplets , Microfluidics , Membrane Proteins , Drug Discovery . Technologies :",
"Scientist . . Enthusiastic scientist with a curious and ' go do ' oriented mind set . Experienced in planning , recording , interpreting , and communicating scientific data from a broad range of techniques applied to proteins , emulsifiers , and polysaccharides . Areas of expertise include : Protein Biophysics Chemical and physical analysis Project management Scientific communication Data analysis . Technologies :",proteins;characterization
"Postdoctoral Research Fellow . . I am a biochemist with over 9 years as PhD student and Postdoc of life science research experience . I have a strong background in structural and molecular biology methodologies , with specific expertise in the following : X ray protein crystallography sample preparation , data collection , and data processing . Cryo EM specimen preparation , Vitrobot System , clipping , and data processing . Protein expression bacterial and mammalian cell expression systems and purification FPLC . Protein characterization SDS PAGE , BLI , SEC . Selection of neutralizing agents for viral infections EBV , HPIV and SARS related virus using yeast surface display . Molecular biology PCR , construct design , and cloning .. Technologies : Xray;CryoEM;BLI",proteins;characterization;interaction;structure
Postdoctoral Researcher . . I m a protein biochemist with major experience in the structural characterization of membrane proteins and their ligands . I work as a postdoc with Natalia Jura at UCSF and my scientific interest lies in developing an atomic scale understanding of how receptor tyrosine kinases regulate signal transduction across the membrane and how aberrant signaling causes human disease . I have lived and worked in many different countries and easily adapt to new environments . I believe that good science and its translation into medicines is a team effort and I am always open for exciting opportunities and collaborations .. Technologies :,membrane proteins;interaction;structure
"Bioinformatics Scientist . . Scientist solving biological problems with computational tools . Extensive training in bioinformatics , mathematics , and computer science . Expertise in genomics , NGS , algorithm development , statistical data analysis , and modeling complex systems . Experience collaborating with a diverse set of research teams making important discoveries in the fields of neuroscience , immunology , genetics and epigenetics . . Technologies :",
"Undergraduate Researcher at Nogales Lab . Studying the Ska Ndc80 complex and its interactions with microtubules using cryo EM . Gained expertise in cloning , protein expressions and purification , and currently learning cryo EM experimentation . . Second year undergraduate at UC Berkeley majoring in Molecular and Cell Biology with an emphasis in Biochemistry and Molecular Biology , and minoring in Data Science with 4 years of experience in the field of molecular biology . Passionate about drug discovery and cancer biology with working and wet lab experience in molecular techniques , protein and enzyme analysis , cryo EM and immunological cytokines . Feel free to reach out to me through my email : nikhitkambdur berkeley.edu . Technologies : CryoEM",proteins;small molecules;interaction;structure
"Director Fibrosis Biomarkers Hepatic and Pulmonary Research . . Assay Development Antibody Expert . Hard working with focus on my work in relation to customer and company success as well as personal . Good research and customer relations has high priority . Author and co author of more than 140 peer reviewed publications on ELISA , ECM , Assay development , preclinical models , clinical studies .. Technologies :",antibodies;characterization;developing
"Senior Bioinformatics Scientist . . Resume : http : sha.wncho.com resume Contact : sh wncho.com Professional bioinformatics scientist , data engineer , and full stack software developer with 5 years of experience . Specializing in helping small to mid size biotech pharma companies with data storage architecture , application development , and delivering data driven insights . . Technologies :",
"Scientific Researcher . . Fellow PhD student of the Leibniz Graduate School on Aging , based at the Leibniz Institute on Aging Fritz Lipmann Institute FLI , Jena , Germany . Her research focuses on understanding the importance of sleep circadian rhythms on neuronal aging and protein aggregation disorders , such as Alzheimer s and Huntington 's disease . Since 2010 , she has conducted research related to sleep , sleep deprivation , memory , and protein aggregation mechanisms . She gained her MSc 2015 in Biology at the Federal University of Rio de Janeiro , Brazil , and her BSc and Teaching degree 2012 also in Biology at the State University of Rio de Janeiro , Brazil . Besides doing research , Isabela has also a fond interest in science communication and outreach activities . As part of her teaching degree , she developed a series of classes explaining the importance of sleep and sleep hygiene during adolescence , which became an ongoing State University of Rio de Janeiro s project . She had also an internship at the Roberto Marinho Foundation Brazil taking part in the promotion and organization of the Young Scientist Award . Since 2020 , she is a member of the Digital Communication committee of the European Sleep Research Society ESRS , bringing awareness to sleep related topics through social media content , webinars , and scientific events .. Technologies :",idps
Senior Scientist . . Structural biologist with an interest in membrane proteins 10 years of expertise in high resolution cryo EM Track record of solving challenging protein structures using single particle cryo EM Experience with expression and purification of eukaryotic proteins including membrane and DNA binding proteins and membrane protein crystallization Extensive knowledge of biochemical and biophysical techniques . Technologies : CryoEM,membrane proteins;structure
Researcher PHD Student . Cryo EM structural biology research of large membrane protein complexes . . Technologies : CryoEM,membrane proteins;structure
"Undergraduate Researcher . This summer I am working under the guidance of Dr. Leonid Peshkin and Professor Marc Kirschner , founding chair of Systems Biology at HMS . I will be working on a kinase regularization , a machine learning project . I am grateful for the opportunity . Hello I 'm Anna Kondylis . Technologies :",
"Principal Bioinformatician . . I am a research bioinformatician with expertise in managing and analysing Big Data within the fields of epidemiology , genomics and drug discovery . I am currently based in the UK working remotely for a Drug Delivery and Therapeutics company in Perth , Western Australia Having been in the field since 2001 , I have developed a substantial knowledge in the application of a wide range of bioinformatics methods to a broad spectrum of biological problems . During my appointment with the University of Cambridge , UK , I single handedly established the core bioinformatics facility at the Cambridge Institute for Medical Research CIMR . Following on from the success of this facility , in 2008 I moved to the Telethon Kids Institute , Perth WA to lead an institute wide programme of Bioinformatics and in 2014 I was invited to join the Institute 's Drug Discovery Group Phylogica to lead all bioinformatics activities and strategy within the company . I have continued in this role as the company migrated to the Harry Perkins Institute and rebranded as PYC Therapeutics . In 2018 I joined part time the Telethon Kids Institute 's Computational Biology group led by A Prof Timo Lassmann where I was primarily responsible for maintaining a computational diagnostic pipeline for the discovery of causal genomic variants in rare disease patients as part of the SeqNextGen project . I am also concurrently responsible for the development of the IT Infrastructure that underpins the research activities of the NIH funded MINERvA Autism study , which enables the combined analysis of significantly large autism registry datasets housed at separate international sites across Europe the USA and Australia . In each role I have been responsible for the installation and maintenance of all bioinformatics hardware and software and the development of custom software to ultimately provide bioinformatics solutions to research questions . This includes the design and implementation of tools to manage and analyse large scale epidemiological data e.g. ViPAR and the rapid processing and analysis of high throughput sequencing and genomic data e.g. FusionFinder , PhySeq , GenIE . . Technologies :",
"Graduate Student Researcher . Performed molecular modelling of protein ligand binding by docking oligosaccharide ligands into X ray and Cryo EM structures of COVID 19 spike protein and other proteins Performed binding free energy calculations with MM PBSA MM GBSA and alchemical free energy simulations using SIRE OpenMM molecular dynamics started from the modelled structures . Calculated ensemble averaged NMR J couplings by performing DFT calculations on sampled structures from molecular dynamics simulations Force field parametrization of modified carbohydrate ligands for molecular dynamics studies Researched quantum chemical reaction path optimization methods and accelerated ab initio molecular dynamics simulations to explore and characterize mechanistic pathways Investigated minimum energy pathways of biologically relevant mechanisms Initiated and maintained collaboration with an EPR lab to investigate a radical mechanism hypothesis Developed features to open source software packages written in Python to allow users to specify force field parameter files and dielectric constants in automated workflows Maintained detailed electronic lab notebook to update PI and collaborators . Computational chemist with skills that span quantum chemistry , molecular modelling , molecular dynamics and interested in a career in early phase drug discovery and development .. Technologies : Xray;CryoEM;NMR",proteins;structure
"Projektleiter . . Breaking down complex problems into palpable questions and finding ways to make the step from data to insights is at the core of the skill set that I acquired during my studies of physics and my subsequent PhD in the field of molecular biophysics . Embedded in an international , interdisciplinary research network bundling biophysical , biochemical and medical expertise , I gained extensive experience in developing and validating biophysical assays , conducting scientific experiments , analyzing and interpreting data , and communicating my results .. Technologies :",characterization
Senior Staff Scientist . . . Technologies :,
"Research Scientist II . Structural and functional analysis of murine norovirus capsid , glutamate dehydroginase and LCIB . Protein X ray crystallography , Cryo electron microscopy . Processing and analysis of Cryo EM data . Virus capsid reconstruction . . . Technologies : Xray;CryoEM",proteins;structure
"Chief Bioinformatician . . Goals To obtain a senior leadership position with international impact within the Bioinformatics or NGS field in a world class academic or commercial organization . To build and lead a team to work on mission critical projects while maintaining strong interactions with internal and external customers . Key attributes I am an enthusiastic team player with first class analytical , design and problem solving skills . I am equally comfortable working at a detailed level and with the big picture .. Technologies :",
Professor at University of Vienna . Assistant Professor at the Center of Molecular Biology . Mechanism of nuclear gene expression regulation My group uses both biochemical and structural biology methods to mechanistically understand the regulation of gene expression . We are particularly interested in RNA metabolism in the nucleus : How are large areas of the genome selectively repressed and how are unwanted RNAs degraded after transcription if they have escaped the first control point We use an integrative structural biology approach combining different methods such as X ray crystallography and cryo electron microscopy to gain insights into the function of the protein complexes involved . . Technologies : Xray;CryoEM,proteins;structure
"Graduate Student . Project 1 : Crystal Structure of Influenza Virus Matrix Protein and Its Biochemical Function Aim : Solve the atomic structure of DM1 and reveal cooperation of its domain in realizing biochemical functions Contributes : The structure of M1 was modeled with software AlphaFold2 , Phenix , HKL2000 , DALI , etc . Its biological function and the role of each domain was tested by liposome flotation , fluorescence polarization and pull down assay . Project 2 : KAT2A acts a histone H3 transferase Aim : Solve the atomic structure of KAT2A together with different ligands and reveal the specific residues involved in the binding site Contributes : Co crystallized KAT2A and multiple ligands and solved the structure . Residues involved in the binding site were mapped through superimposition among KAT2A interested ligand , KAT2A succinyl CoA , KAT2A acetyl CoA. Project 3 : Cohesin SA2 are RNA binding proteins and its N terminal domain is responsible for the binding Aim : Solve the structure of SA2 and analyze the RNA and DNA binding ability of both full length SA2 and multiple truncated versions of SA2 Contributes : Preliminary structure of SA2 was solved through Cryo EM . Their RNA and DNA binding ability was detected through fluorescence anisotropy assay using TECAN plate reader . . Ph.D. candidate in structural biology at Rice University . I worked on tumor targeted therapy and immunotherapy during my bachelor study as well as in the Chinese Academy of Science . I mainly worked on mammalian cell culture and animal model building at that time . And then I dived into more fundamental research in the structural biology area and study about the viral protein structure . I have been working on multiple expression systems including E.coli , insect cells , and mammalian cells . Skills : Structure biology : PCR , Protein Purification , Affinity Chromatography , Ion Exchange Chromatography , FPLC , Transmission EM , Cryo EM , Crystallography Biochemistry : Western Blot , Immunoprecipitation , Liposome Flotation Assay , Fluorescence Anisotropy , ELISA , Flow Cytometry , TCID50 and LD50 Measurement , Periodic Acid Schiff stain , Feulgen stain , paraffin section and hematoxylin erosin stain Cell Animal : E.coli Culture , Insect Cell Culture , Mammalian Cell Culture , Animal Model Building with Mouse , Drosophila and Rabbit , Drosophila Melanogaster 's Hybrid Experiment , Nude Mouse Mouse Lavage , Mouse Subcutaneous Injection Computer Science : Python , R , MySQL , PostgreSQL , MongoDB . Technologies : CryoEM;FP",proteins;interaction;structure
"Graduate Teaching Assistant . Expected graduation August 2022 Graduate Student in the Chemistry and Biochemistry department at the University of Arkansas . Project Title : Structural Determination of Collagenases G and H from Hatehewaya histolytica . Tasked with determining the structure of two bacterial collagenases primarily using Small Angle X Ray Scattering SAXS , Cryo EM , and limited proteolysis SDS PAGE analysis . Additionally tasked as a regular TA for chemistry teaching labs , and summer lecture courses . Proud mentor of 9 undergraduate students and the awarding of 7 undergraduate honors grants . . An experienced graduate with a history of working in the life science field . Skilled in Learning Assistance , Communication , Molecular Biology , and Biochemistry . Hoping to pursue a career in the life sciences . Advocating for healthy work life balance for students . Having issues or questions facing undergraduate graduate studies Please reach out . Technologies : Xray;CryoEM",proteins;structure
Scientist for Cryo Electron Microscopy . . . Technologies : CryoEM,structure
"Bioinformatics Scientist . support in algorithm development and implementation of statistical modeling and machine learning design data imputation algorithm for missing and minor nutrient value in food nutrient database design bioinformatics analysis pipeline for the NGS based genetic panel test support in NGS panel product design lose 20 pounds with GB HealthWatch 360 Moble apps . 100 hard worker ; 90 quick learner and critical thinker ; 80 team worker ; 70 statistical modeling and machine learning implementer ; 60 computer programmer and 50 biologist . Sound skills in both statistics and machine learning . Experienced in apply , modify and design algorithms to analysis dataset in bioinformatics research projects . Familiar with the current bioinformatics trend . Understand the concept about molecular biology , cancer genomics , pharmacological and pharmacogenomics study . Experienced with common process pipeline of dataset in the bioinformatics area such as Microarray , ChIP Seq , RNA seq , MBDCap Seq , etc . Skilled in high dimensional data visualization and analysis , familiar with the state of the art feature selection , dimension reduction methodology and modern data visualization technique . Familiar with public available data portal and tools such as GEO , TCGA , UCSC , DAVID . Solid record of publication in peer reviewed journals and presentations in regional and international conference . Strong written and verbal communication skills in English and Chinese . Strong commitment to team environment dynamics with the ability to contribute expertise and follow leadership directives at appropriate times . Computer software skills : MATLAB , R , C , JAVA , SAS , Microsoft office . Research interest : Bioinformatics Computational biology Large scale data analysis Algorithm development Feature selection and dimension reduction Statistical Modeling Contact : carter.ma gblifesciences.com work chifeng.ma yahoo.com personal cell 210 601 5097 all time . Technologies :",
"Scientific Engagement Manager . . I have 11 years of work experience in the field of Bioinformatics , with expertise in handling multi omics datasets . I have designed pipelines workflows on next generation sequencing such as genomics , proteomics , metagenomics , transcriptomics NGS datasets . I have used machine learning techniques to learn from NGS datasets . I have designed and managed SQL databases . I am proficient in R , Python , PostgreSQL , Linux , Database development management . I am looking to expand my expertise and insights gained from handling multi omics datasets . I possess deep inclination towards learning advanced computational and statistical methodologies , new sequencing technologies and application of well established concepts and techniques in the field of Bioinformatics . I am a quick learner and I work very well either independently or as a part of a team . Through these years of working in the field , I have led and managed teams and understood the nuances of what makes a team efficient and strive towards a common goal . With the multi omics experience , I am come well equipped to handle any kind of omics dataset and learn quickly and efficiently about the current trends in the field . I look forward to working with intelligent and scientifically driven individuals who will not only help me hone my skills but also strive towards to a greater goal of serving the life sciences industry .. Technologies :",
"Scientist Formulation Development Wetenschappelijk medewerker formulering . . Jolanda is an enthousiastic , motivated and ambitious industry pharmacist , with a passion for drug product development . She is a well organized , data driven , analytical professional currently working as a Scientist in formulation development in biotechnology industry . Her passion is to solve the challenges related to drug product development in the various stages of the product towards the market . Jolanda is skilled in formulation development of small molecules , vaccines , proteins and liposomes , working under GLP and GMP conditions , setting up relevant and lean experiments using DoE and interpretation of the resulting data of a wide variety of analytical techniques . She has a strong scientific mindset , but is also able to see the business perspective of the study results . Jolanda likes working in a team : Together Everyone Achieves More is a strong value for her . . Technologies :",biologics;carriers;proteins;formulation
"Senior Research Scientist . Investigated novel molecular glues for targeting AML cells which involved studying the mechanism , establishing in vitro and in vivo efficacy assays , finding therapeutic index in mouse and human systems , pharmacodynamics of targets in AML mouse models . Discovered that IKZF2 regulates chromatin accessibility of HOXA9 self renewal gene expression program and inhibits a C EBP driven myeloid differentiation program in Leukemic Stem Cells . Investigating the role of RNA binding protein , Musashi 2 MSI2 in Leukemic Stem Cells revealed that MSI2 maintains translation of MLL fusion targets required for LSC function . Studying the role Msi 2 in Hematopoietic Stem Cells uncovered that MSI2 regulates translation of TGF beta signaling molecules to maintain myeloid biased HSC and myeloid reconstitution . Studying the roles of novel regulators required for stem cells in normal hematopoiesis and leukemia , aimed at finding new therapeutic targets for treatment of hematologic diseases . Implementing genetic mouse models , flow cytometry and functional genomic tools to understand underlying mechanisms . Current work involves using molecular glue degraders to target leukemic cells in vitro and in vivo involving primary patient cells and PDX . Have strong background using different cancer mouse models of blood , colon and ovarian cancer .. Technologies :",molecular glues;nucleic acids;small molecules;interaction;screening
"Bioinformatician : Research Associate . A genetic based multi tissue classification of human ageing . . I am a computer scientist with a good knowledge of mathematical modelling techniques , programming , artificial intelligence applications and methods , and microarray analysis . I have excellent background in developing 2D models and simulations for dynamic behaviour of tumour . I have good command on programming languages including Java , Matlab , Python , C and C . Regarding my teaching experience I worked as teaching associate for almost two years at University of Bradford , UK and also completed a teaching placement at Grange Technology College GTC , Bradford . During my teaching experience , I helped students during the tutorial sessions and in individual meetings . I prepared and delivered lectures to undergraduate and postgraduate students including real time systems RTS , information engineering IE and programming languages Java . I have extensively worked in a multidisciplinary environment during my research career . I am experienced and skilful in wide range of experimental techniques and research methodologies .. Technologies :",
"Postdoctoral Researcher . cryoEM project management from sample preparation to Titan Krios day to day operation including data acquisition and processing , model evaluation and publication design , data acquisition and evaluation of structural biology projects . The function of a living cell is defined by the activity and interactions of its protein complexes . Understanding the properties of these interaction networks is necessary to predict cellular fate , in particular during malfunctions in disease . I am integrating systems and structural biology approaches to generate models of pathways and protein complexes . I studied genetic interaction networks of histone mutants to gain insights to transcriptional regulation as well as to extract structural models of protein complexes involved in chromatin biology . For the past years I have returned to using cryo electron microscopy single particle analysis to study protein protein interactions in a close to native state . Here my research is centered on protein complexes of the ubiquitin proteasome pathway , in particular in the elucidation of transient interactions . Moreover , I am continuing my early stage research of viruses and plants , to gain insights of viral protein structures as well as the assembly process of photosystem II .. Technologies : Xray;CryoEM;SLS DLS;MST;AUC;DSF",proteins;structure
Thiel Fellow . . . Technologies :,
"Head of Biomedical Research . . Computational chemist specialized in statistics , computational modeling , software development , and data analysis . Experienced working in cross disciplinary teams , and leading projects . Exceptional communication skills , with seven awards for conference presentations .. Technologies :",
"Principal Curator and Disease Selection Team Lead . . I am proud to work for Healx , an amazing startup biotech company in Cambridge , UK . Healx harnesses scientific insight into rare disease with AI and Big Data to identify drugs which can be repurposed for rare disease patients . I work within a team of scientific curators whose task is to identify potential leads and understand all aspects of rare disease pathobiology . Healx curators work alongside AI technicians , bioinformaticians and pharmacologists , as well as key opinion leaders , charities and patient groups , in order to refine predictions of potential drug targets that can ultimately undergo clinical testing and be brought to market . Such work is extremely rewarding . I have a university education in molecular biology , molecular evolution , phylogenetics and biostatistics with extra curricular training in historical database inquiry . I previously worked as a scientific database curator at the European Nucleotide Archive at EMBL EBI for nine years , dealing with data standards and curation in taxonomy , biological samples , sequencing traditional and nextgen and feature annotation . Prior to that , I worked as a computation biologist in the Sanger Institute 's HAVANA team for just over three years . There I conducted genomic annotation on the human genome as well as contributing the annotation of eight haplotypes of the human MHC region to the international HapMap project . Skills : Rare Disease Biology , Molecular Biology , Molecular Evolution , Database Curation , Biological Reporting Standards , Genomic Annotation , Biocuration , Phylogenetics , Biostatistics and general Computational Biology .. Technologies :",
Postdoctoral Researcher . Designed a modular live cell fluorescent barcode that can provide longitudinal imaging in neuron development . Developed a magnetic cell sorting technique with genetically modified cell lines to improve initial FACS sorting by 20 Demonstrated capability and expertise in the following : fluorescent imaging ; different cloning strategies ; fluorescent probe design ; cell segmentation ; and CRISPR . Worked on a collaboration for CRISPR knock in for studying protein complexes with cryo EM determine candidacy to improve future drug screens . Postdoctoral Researcher in Bo Huang 's Lab at UCSF generating live cell barcodes for longitudinal imaging . Working towards designing these for organoid models . Research interest : Theranostics ; nanoparticles ; bio imaging ; cell culturing ; 3D printing ; lab on chip ; assay optimisation and development . . Technologies : CryoEM,
Research Assistant . Automising internal workflows NGS prep and protein purification using Opentron system . Upscaling and optimising procedures for antibody screening with deepCDR . Contributing to the establishment and growth of ETH start up spin off company deepCDR . Applying bioinformatics and deep learning tools to antibody research and engineering . . . Technologies :,antibodies;engineering;expression;screening
"Researcher . Working under Dr. Bob Lahue to develop a tri nucleotide repeat expansion assay as part as of project with other academic and commercial partners . . Research scientist with project management experience in a GMP environment . Currently a project leader at Charles River Laboratories in their Biosafety , Cell Based Assays and Virology Department . Previously worked at Fusion Antibodies , developing a mammalian display platform for antibody discovery . Previously worked at Roche Innovation Centre Zurich Roche Glycart in the cell and molecular technology department , developing biological tools to support the ongoing research there . Engineering tumor cell lines , immune cells and organoids via viral systems and transposon systems , as well as CRISPR engineering to create knock outs and for targetted integration of transgenes . . Experienced in 2d and 3d cell culture . Previously worked at Roche in their Pharma R D division Penzberg Germany with the task of developing stress fermentation models for better evaluation of CHO clones for suitability in large scale fermentations . Also introduced automation to their 2L CHO fermentation process . Recently graduated with a Master 's in Bio Process Development from the Mannheim University of Applied Science . . My work history to date has had a large emphasis on the following topics : mammalian cell line engineering and cell culture , genomics , biomedical imaging , medical devices spectroscopy , optics , biochemistry and regenerative medicine . I have been exposed to many different technical fields and have performed very well in them . I am a person who contributes positively to any professional environment . I am always happy to make new connections on LinkedIn . . Technologies :",
"Senior Business Analyst . Business analysis for the development of a FAIR data model and data ingestion flow of multi omics data . . I help pharma companies to switch into Agile in their IT projects to get the best performance . Experienced IT consultant with strong technical background and problem solving skills . More than 15 years experience as a Business Analyst , Bioinformatics Researcher and Software Developer . Computer Science Degree . Sun Certified Java Programmer and Certified Scrum Master . Ignite program on innovation at Stanford University . Extensive experience in Agile methodology and gap analysis . Requirement elicitation , Stakeholder discovery and mapping , creation of backlogs for MVP , Workshops , Demos , coaching and mentoring Business Analysts . Excellent communication skills . Key Skills : Computer Systems Validation CSV documentation : writing of User Requirements Specification URS , Functional Specification FS , Traceability Matrix . User Stories INVEST standard , Kanban Scrum Board Management , Backlog Prioritisation , User story mapping , Behaviour Driven Development , Refinement Sessions eg 3 amigos , Process Mapping for Gap Analysis BPMN diagrams , SCRUM , Product Roadmap Definition , Stakeholder Management What can Agile4Pharma do for you : Lead your company transition into Agile in a tailored way Train your Business Analyst team to be the driving force for the change Fine tune the software development process to make it high performance Establish a Continuous Improvement Model Contact me for more information and I will be pleased to discuss with you the best options for your company : hello agile4pharma.com . Technologies :",
"Manager CMC Management RNA . DS Lead . I love to interact with people my colleagues , people from different fields or with different background . I am caring and helpful . Regarding work , I am reliable and very critical with my results . I love new challenges and approaches . To recharge I seek the woods and mountains , either climbing , hiking or cycling . In the past 2 years I have been working for Heidelberg Immunotherapeutics . Starting as a Research Associate in the preclinical development team I 've been helping to characterize the epitope of the company 's anti HSV 1 2 antibody and proving its function in the mouse model . In addition , I started to work as a CMC porject manager , managing stability studies and basically everything concerning the IMP at the CMOs end . In the same way , I 've been supporting the clinical trial managers with everything regarding the IMP for two phase II clinical trials such as shipping or contributing to the IMPD and other essential documents . Bofore , I worked for Horizon Discovery and The Antibody Lab . I mastered my skills in cell culture up to the 10L bioreactor level and in various molecular biology techniques . Using CRISPR Cas , working with iPSCs and developing reporter cell lines or antibody secreting cell lines for example . What I enjoyed most during this time : to be involved in project design , streamlining processes and improving results . I finished my MSc with emphasis on immunology . During my thesis , I had the chance to learn the complex patch clamping technique and doing electrophysiological measurements . Between 2009 and 2011 , I gained my first serious hands on experience in the lab at the INMR in Sydney as part of my BSc program and thesis . At the INMR I established a method to isolate primary cardiomyocytes from the mouse heart for example . Last but not least , as a student and between jobs I always worked in outdoor sport shops 10 year experience . Having the opportunity to share my outdoor travelling experience with customers and helping them to find the best product and technology according to their needs . Happy to connect cheers . Technologies :",antibodies;characterization;engineering;stability
"Principal Scientist , Translational Biomarker Flow Cytometry , TME TRC Translational Development . . While my day job revolves around utilizing my 10 years of flow cytometry expertise to advance clinical programs , I am truly passionate about supporting employees to develop professionally and personally . I believe in the mission of employee resource groups as a means of generating the psychological safety necessary for scientists to feel comfortable sharing their ideas and concerns , generating more efficient and innovative teams . Technologies :",
"Senior Scientist , Advanced Drug Delivery , AstraZeneca . . Curious and hands on scientist interested in developing novel technology to solve challenging real world problems . I have been working on multidisciplinary projects on the development of affordable , easy to use , disposable diagnostic devices for disease monitoring and management at the Point of care PoC . I am also working on the development of handheld sensors for monitoring levels of contaminants in drinking water . During my PhD and Post Doc have developed assays and biosensing platforms for studying the function of membrane proteins in a native like environment . My interests in solving challenging scientific questions are broad and worked on nanotoxicology , developing assays for the toxicity of ZnO nanoparticles to cells .. Technologies :",membrane proteins;developing
Senior Bioinformatician . Vertebrate Resequencing Informatics . . Technologies :,
"Bioinformatician , Centre for Chronic Disorders and Diseases C2D2 . C2D2 is a cross disciplinary initiative funded by the Wellcome Trust and aims to reduce the burden imposed by chronic diseases and disorders by providing strategic support for research . It brings together staff from the Departments of Biology , Health Sciences , Mathematics , Computer Sciences , and more , fostering new partnerships and enabling exciting new research in this important field . . After studying bacteriology during my undergraduate degree , my Ph.D. combined in vitro and in silico analyses of the bovine respiratory pathogen Pasteurella multocida , specifically the role of iron acquisition in bacterial virulence . The work resulted in a new model of the way in which iron availability influences the virulence of the bacteria in the bovine respiratory tract . Building on the theme of host microbe interactions , my postdoctoral work investigated the metabolic symbiosis between the pea aphid and its bacterial symbiont Buchnera . Exploiting an in silico metabolic model of the bacteria , we built a model of the specialised aphid cells , the bacteriocytes , in which the bacteria are housed . Close collaboration with Angela Douglas ' lab at Cornell University provided next generation sequence data , transcriptomic data , proteomic data and metabolic data to inform the model building . Recently , I 've completed a Masters degree in Computational Biology at the University of York , broadening my range of bioinformatics and data analysis skills . As part of this , I worked in the lab of Toni Gabaldon at the Centre for Genomic Regulation in Barcelona , building a genome scale phylogeny of the tsetse fly . Currently , I am working as a bioinformatician as part of the Centre for Chronic Diseases and Disorders C2D2 initiative at the University of York . I provide bioinformatics expertise to researchers working across the University as part of this cross disciplinary and cross departmental initiative . Specialties : host microbe interactions , systems biology , construction of in silico metabolic models , SBML Systems Biology Markup Language , flux balance analysis , flux variability analysis , gene deletion analysis , genome annotation , next generation sequence analysis , SNP analysis , data parsing , Python programming , database design and implementation , phylogeny . Technologies :",
"Senior Scientist . . Cryoelectron microscopist over five years of experience and four high resolution structures solved with a passion to discover new protein structures and expand available therapeutics Skills : Cryo EM grid preparation , data processing using various software such as Relion , CryoSparc , EMAN2 , Scipion , Xmipp , among others , TEM operation and alignment Arctica , Krios , Jeol , BioTwin Spirit using EPU and SerialEM , model building using PHENIX and COOT . Computation Shell Python scripting , Matlab Octave , familiar with HPC environment such as PBS , basic machine learning , molecular dynamics using Amber and NAMD , protein structure prediction using Rosetta and various bioinformatics tools Biochemistry Design and optimization of assembly reactions of protein complexes in stable states , gel filtration using AKTA systems Personal experience : The first project that I was able to use my cryo EM skills in a health oriented target was the determination of the high resolution structure of the human immunoproteasome . To put in context the importance of this particular protein , it is a key target in the treatment of patients with multiple myeloma , B cell autoimmune disorders and rejection of organ transplant recipient . Although there were several challenges in the project , the importance of not only obtaining the first structure of this target but also revealing the mechanism of which a new , versatile small molecule scaffold interacted with the protein fueled my passion . . Technologies : CryoEM",proteins;structure
"Director , Research and Discovery . . I see myself as highly dedicated to all endeavors I undertake , and with a true passion for working with molecular pathophysiology in an entrepreneurial environment , from the conception of new therapies to commercialization . This drive has taken me from an initial start up focused on heart disease , to the completion of an industrial Ph.D. in structural biology within bleeder s disease . I recently augmented my scientific background by completing a M.Sc . BA in Bioentrepreneurship at Copenhagen Business School . This combination of drive , experience and educational background translates into a focus on detail , while ensuring the timely generation of high quality scientific data that facilitates innovative solutions . In my leisure time I enjoy hiking , diving and hunting while travelling as much as time allows . Teamwork oriented High academic skill level Biopharmaceutical development . Technologies :",biologics;developing;structure
"Staff Software Engineer in Research . . I m a software engineer working in research at DeepMind , with a background in biology .. Technologies :",
"Speech and Language Therapist Assistive Technologist . . Specialties : assistive technology , disability , ICT and web accessibility , Speech and Language therapist , alternative formats and now building on the work we did for an Arabic Symbol dictionary for AAC users and those with learning or language difficulties acquiring literacy skills . We have launched Global Symbols and hope to link up many more AAC symbol sets . Also looking into AI and Inclusion as part of an Alan Turing Institute Pilot Project . . Technologies :",
"Senior Computational Biologist . Tech Lead , Structural Variation Team , Data Sciences Platform Methods Group I design , develop , and evaluate computational methods for processing NGS data within the Genome Analysis Toolkit GATK . Focusing on methods for structural variation detection , I develop algorithms and pipelines for accurately calling variants from sequencing data . As tech lead , I provide guidance , advice , and technical leadership to a team of computational biologists and engineers working on implementing state of the art structural variation detection methods meant for the Broad Institute 's research and clinical pipelines . Computation Biologist , McCarroll Lab , Stanley Center for Psychiatric Research I design methods and conduct analyses to better understand copy number and structural variation . My focus is on detecting and analyzing copy number variation in regions of the genome that are difficult to access with standard algorithms for processing short read data . I contribute to research projects that aim to understand complex forms of structural variation and their association with disease risk and other phenotypes . . Computational Biologist at the Broad Institute . I work on analyzing genomics data , specializing in detecting copy number variation and other forms of genomic structural variation , and analyzing how these variants are formed , segregate in populations , and affect disease biology . I write algorithms in GATK and related software projects . My PhD was in computer science , with a focus on computational biology and bioinformatics , working on projects analyzing next generation DNA sequencing data using distributed computing frameworks and machine learning . Former senior software engineer for distributed and web applications . Specialties : Bioinformatics , Genomics , Structural Variation Detection , DNA Sequencing , Cloud Computing , Machine Learning , Data Science , Distributed Computing , Spark , Internet and Web Application Development , Agile Software Development , Java , R , Python , HPC , Scala , Google Cloud Platform , WDL Cromwell .. Technologies :",
Senior Clinical Informatics Scientist . . . Technologies :,
Professor . http : profiles.umassmed.edu profiles display 129880 http : www.umassmed.edu mccb faculty MCCB faculty MCCB faculty profile pages zhu julie http : www.umassmed.edu mccb bioinformatics core software . . Technologies :,
"Vice President , Automation and Process Optimization . Heading up the Digital Science Innovation efforts to further automate across research and early development . . Protein scientist with expertise on the automation and production of proteins for structure and therapeutic discovery uses , with a particular emphasis on eukaryotic production and membrane proteins . Now focused on all forms of automation and process optimization across the R ED areas of Novo Nordisk .. Technologies :",membrane proteins;expression
Applications Manager of Life Sciences . I develop global marketing strategies to drive Life Science business growth and sales effectiveness at Gatan Inc. worldwide . I analyze emerging trends in the Life Science sector and work with product management and engineering to develop competitive strategies . . Developing global marketing strategies and improved methods for cryo electron microscopy with energy filtered direct electron detectors . Technologies : CryoEM,
"Principal Scientist , Computational Biology . . Subject matter expert , technical lead , and functional manager for Medical Imaging and Biomarker Analysis R D. Experience includes imaging physics , clinical applications , image analysis , and genomics . Subject matter expertise in digital pathology , nuclear medicine , X Ray and CT , functional imaging , and bioinformatics . Ability to successfully work in both , highly regulated medical device and diagnostics development and fast paced research and advanced development environments . Areas of work include research , advanced development and prototyping , requirements analysis , regulated medical device development , pre clinical and clinical validation .. Technologies : Xray",
". . My specific area of research is the Molecular and Cellular Biology , Biochemistry and Pharmacology of the G protein coupled receptors and tyrosine kinase receptors . In particular , I am interested in the allosteric receptor receptor interactions within heteroreceptor complexes and their biochemical , pharmacological , and functional integrative implications in the central nervous system . The existence of heteroreceptors with allosteric receptor receptor interactions markedly increases the diversity of membrane receptor recognition , trafficking , and signaling and has become an important area for developing more selective drugs .. Technologies :",membrane proteins;interaction
"Production Scientist . . I am currently a Junior Cell Culture Scientist Production Scientist at BioServUK in Sheffield . I have a Masters degree in Biological and Bioprocess Engineering from the University of Sheffield , where I graduated in September 2017 . In addition to this , I have a Bachelors degree in Biology , which is also from the University of Sheffield . . Technologies :",
"Principal Protein Scientist . Research scale protein production providing proteins for biochemical screening and structural biology in support of a range of Crop Protection Research CPR projects . Other activities include chloroplast preps for MoA studies and process scale protein purification to produce regulatory test substances . Recent activities over the last few years has involved establishing membrane protein screening platforms . A highly creative Principal Protein Scientist and expert in protein production with over 30 years experience in an industrial setting . Recognized industry leader in the field of protein science . Extensive protein expression experience including shake flasks and fermentors with E.coli and Yeast . Protein purification expertise in all major AKTA chromatographic platforms including Pure , Avant and Pilot . Highly familiar with all associated chromatography techniques e.g. ion exchange , affinity , SEC with a broad range of protein characterisation skills e.g. SDS PAGE , Western blotting . Good experience in molecular cloning and protein expression work with cell free , insect and mammalian expression systems . Work experience ranges from the supply of antibody biotherapeutics and test substance samples ranging from research scale to process scale production and extensive small molecule drug discovery projects including target provision for HTS , structural biology and biophysical studies . Recent activity over the last 6 years has involved establishing membrane protein expression screening platforms see publications and purifying membrane proteins for structural biology recent success has provided a membrane protein giving novel ligand bound diffracting crystals supporting SBDD . Highly self motivated individual and excellent communicator across all levels of the organisation and with external collaborators . Extensive experience working with CROs and academic groups to stay on the cutting edge of technology and expanding deliverables . Proven track record of delivering against aggressive timelines with multiple challenging projects , both in an individual and supervisory project management role .. Technologies :",proteins;characterization;expression;structure
"Professor of Open Science . . A deep background in theoretical and computational Physics , coupled with a more recent move into Computational Biology . Goals To collaborate closely with experimental Biologists and with them develop an understanding , at a molecular level , of how organisms function . Specialties : Background : Computational and Theoretical Physics . Computational Biology . Protein DNA interactions . Cloud Computing . Skills : Expert C MPI , Perl and R coder . Experience of Java particularly with threads . Beginner in Python . Experience of C and ASP.NET on the Azure cloud computing platform . Analysing microarray data . Reasonably strong statistical skills .. Technologies :",
"Lead Biologist and Project Manager in Drug Discovery at CD3 CISTIM . . Biomedical research scientist with experience in academia and biotech industry . Background in immunology , virology , inflammation , metabolic diseases and tissue fibrosis . Expertise in development and implementation of screening assays for both enhancing R D platforms in drug discovery as well as for preclinical research with small molecules and antibodies . Proven track record in project management , successfully directing various scientific projects in international , multi site and interdisciplinary academic and industrial research teams . Enthusiastic about bridging academic and industrial partners to implement novel approaches for target discovery and development of first in class drugs . . Technologies :",antibodies;small molecules;screening
"Senior Scientist . Design and synthesis of novel therapeutics for the treatment of malaria and tuberculosis . . Ph.D. medicinal chemist with more than 10 years pharmaceutical industry experience focused on the creation of novel pharmaceutical entities . Technical : Diverse synthetic background including both solution and solid phase chemistry Diverse variety of therapeutic areas including CNS , inflammation , fertility , and oncology . Key contributor in a variety of multi disciplinary teams focusing on a range of target types including GPCR antagonists and agonists , kinase inhibitors and a variety of other small molecule antagonists . Leadership : Provided technical and strategic plans to the team in chemistry driven projects ; developed Go No Go strategy on lead series to move projects forward . Team leader : time management , schedule planning , risk assessment and resource management resulting in completion of two large solid phase libraries . Responsible for mentoring a number of highly talented research associates . Communication : Worked in a wide variety of external collaborations : responsible for presenting and communicating progress and plans both internally and externally with corporate partners and CRO s. Responsible for data management of synthetic procedures , chemical compound inventory , combinatorial library compound inventory and assay results . Specialties : Drug discovery research utilizing medicinal and organic chemistry in the design and synthesis of novel pharmacological entities as well as the definition of structure activity relationships .. Technologies :",small molecules;developing
"Research Scientist , Bioinformatics . Data science lead and support for discovery research in immunology , inflammation and fibrosis . Extensive analysis of single cell and bulk RNA seq datasets pre clinical models , clinical trials data to evaluate targets of interest . Building in house single cell RNA seq data visualization tools for enabling quicker data driven decisions . Developed novel strategy for patient stratification using machine learning methods . Managing and supporting academic and external collaborations to support target ID and evaluation . . I am highly accomplished computational data scientist with 6 years of experience in cancer genomics , machine learning and protein structural biology . I am interested in using high throughput omics datasets genomics proteomics to develop analytical pipelines for biomarker discovery and personalized cancer therapy using systems and machine learning approaches . I 'm looking to connect with people in related fields and explore opportunities . Areas of expertise : : RNA Seq bulk single cell , Proteomics , Bioinformatics , Machine learning , proficient in Python , R , Perl . Technologies :",
"Co Chair Metro New York Chapter . Women In Bio is an organization of professionals committed to promoting careers , leadership , and entrepreneurship for all women in the life sciences . Yana Zorina , Ph.D. is a translational cell biologist with 15 years of experience in neuroscience , signal transduction , systems biology , and oncology in academia and industry . She has in depth expertise in cell signaling , biochemistry , molecular pharmacology , mechanism of action studies , high throughput assay development and screening , and translational research . During her graduate and postdoctoral studies , Yana worked on developing a poly pharmacological treatment for acute central nervous system injury and delineated the signaling mechanisms that regulate neuronal differentiation and axonal regeneration . Yana then moved to a biotech company , whe s investigated the mechanism of action of a remyelination promoting antibody for multiple sclerosis . During this time , Yana has led preclinical mechanism of action studies , developed in vitro assays for lot release potency testing and managed several large collaborations at academic institutions and CROs . In her current position at MSKCC , Yana performs high throughput and high content image based screening , using RNAi and drug libraries to identify novel drug candidates and targets . Taken together , Yana has over 15 years of experience in biomedical sciences that ranges from basic research to drug development . . Technologies :",proteins;screening
Student Internship . Intern at the Pharmaceutical Development Biologicals Department Task : Evaluation of predictive parameters for protein storage stability and evaluation of a new device for the Measurement of Intrinsic Fluorescence and Dynamic Light Scattering . . . Technologies : SLS DLS,proteins;stability
"Bioinformatics Scientist . Support new product introductions NPI , focusing on sequencing and analysis strategies for oncology , inherited diseases , pathogen identification and other novel applications Translate new product requirements into prototype and production level software Support new panel development and monitor performance of existing products Employ data mining and machine learning for system improvement and troubleshooting Work closely with molecular biology , product management and bioinformatics colleagues current official title is Sr Manager , Bioinformatics . 15 years experience collaborating on multidisciplinary research projects . Expertise in data analysis , bioinformatics , mathematical modeling , operations research , statistics , computational biology , machine learning , algorithm development , optimization , differential equations , numerical analysis and software development . Also knowledgeable about : molecular biology , biochemistry , virology and immunology , systems biology , populations genetics . 20 years programming experience , including : Python , C , MATLAB , SQL , R , Java , Perl , IDL , shell scripting , Pascal , Fortran , Visual Basic , and Smalltalk object oriented language . Experience writing about and presenting complex subject matter in an understandable way to varied audiences with both technical and nontechnical backgrounds . Highly motivated and passionate about applying computational methods in the sciences . Track record of adapting to evolving company project needs .. Technologies :",
Laboratory Scientist . Cancer research at the Cryo EM laboratory . . Technologies : CryoEM,structure
"Freelance researcher . Have brain , desire to use it to help banish Alzheimer 's , semi retired so flexible and available now . . Desired position An intellectually challenging role as theorist analyst project manager in a programme contributing to our understanding of neurodegeneration and or ageing . One novel approach would be an AI research project aimed at complementing enhancing our problem solving capacity ... Previous career roles Freelance tutor HNC D computing , A level psychology and GCSE science 2002 2004 . Software developer to project manager commercial software , IT industry 1979 2001 . Academic papers Wilson RJ 2009 Kinesin s walk : springy or gated head coordination BioSystems 96 , 121 6 Wilson RJ 2008 Simulating the Kinesin Walk : a Small Step towards Understanding Dementia . IEEE UKSim European Symposium on Computer Modelling and Simulation , 226 31 Wilson RJ 2008 Towards a cure for dementia : the role of axonal transport in Alzheimer s disease . Science Progress 91 1 , 65 80 Qian M , Zhang X , Wilson RJ , Feng J 2008 Efficiency of Brownian Motors in terms of Entropy Production Rate . EPL 84 1 , 10014 Harris RL , Musgrave G , Wilson RJ 1981 The design and implementation of a waveform description and test programming language for CAD of digital systems . IEE Electronic Design Automation Conference , 203 7 . Brunel MSc dissertation Wilson RJ 1978 Cyclic behaviour in some autonomous sequential networks . MSc dissertation , Brunel University , UK simulation of recurrent , weightless , artificial neural network for unsupervised pattern recognition . Other publications Wilson RJ 2000 Two articles : Cognitive Psychology and Cognitive Science , in Microsoft s Encarta encyclopaedia millennium edition Wilson RJ 1998 Book review of Aleksander I 1996 Impossible Minds , My Neurons My consciousness , Imperial College Press : London . Journal of Consciousness Studies 5 1 , 115 6 . Specialties : Scientific research , team and project management , problem solving and analysis , software design and development .. Technologies :",
"Principal Scientist , BioMedicine Design . . I work at BioMedicine Design at Pfizer where I m responsible for discovery of antibodies and design of various modalities for new therapeutics . I lead several discovery programs in oncology . How did I get here I m inherently interested in integral membrane proteins , conformational heterogeneity and how to capture it by structural means . Another aspect I love is understanding conformation function relationships . Turns out , antibody phage display is a great way to make specific binding domains that can be both used in structural biology and in potential therapeutics . I m very lucky to be able to contribute to a wonderful team of talented colleagues , exchange ideas with experts in their fields , and interact with multidisciplinary teams to bring novel medicines that can ultimately change patients lives . I love what I do . Technologies :",antibodies;membrane proteins;developing;interaction
"Chief BioMedical Scientist . Apply medical data and clinical knowledge driven learning methods on clinical multi omics to solve clinical challenges as well as study mechanisms of actions in human diseases by multi omics methods , including single cell omics . . As a leading expert in biomedical data science and administrative member in industry with more than 13 years working experience , my personal interests focus on developing high dimensional data solutions in medicine . By means of machine learning , bioinformatics and computational biology , my team is exploring the mechanism of aberrant biological events in human diseases and seeking potential medical interventions , including 1 knowledge and data driven decision making strategies in clinical scenarios ; 2 multilayer data analysis , visualization , interpretation and summarization by combining phenotype and genotype data ; 3 commercial and open source products development ; 4 consulting for fundamental research and clinical applications . I am also one science enthusiast with extensive experience on performing and administrating cloud based data driven projects in biology and medicine by building , developing , leading and coordinating dynamic teams . Select 4 peer review publications from more than 20 publications 1 . Alhasan AH , Scott AW , Wu JJ , Feng G , Meeks JJ , Thaxton CS and Mirkin CA . A Circulating MicroRNA Signature for the Diagnosis of Very High Risk Prostate Cancer , Proc Natl Acad Sci U S A 2016 Sep 20;113 38 : 10655 60 2 . Bhattacharyya S , Wang W , Morales Nebreda L , Feng G , Wu M , Zhou X , Lafyatis R , Lee J , Hinchcliff M , Feghali Bostwick CA , Lakota K , Scott Budinger GR , Raparia K , Tamaki ZT and Varga J , Tenascin C is a key factor driving persistence of organ fibrosis , Nature Communications , 2016 Jun 3;7:11703 3 . Yan X , Sablok G , Feng G , Ma J , Zhao H and Sun X. nagnag : Identification and quantification of NAGNAG alternative splicing using RNA Seq data . FEBS Lett . 2015 Jul 8;589 15 : 1766 70 . 4 . Bao R , Huang L , Andrade J , Tan W , Kibbe WA , Jiang H and Feng G corresponding author , Review of Current Methods , Applications and Big Data Management for the Bioinformatics Analysis of Whole Exome Sequencing , Cancer Informatics , 2014 Sep 21;13 Suppl 2 : 67 82 . .... Technologies :",
"Scientist II . . Thanks for exploring my profile . After an unforgettable experience teaching science and coaching robotics at a public high school , I m back doing scientific research at Relay Therapeutics . I m happy to be collaborating productively with smart , fun colleagues while building computational models to enable our discovery platform .. Technologies :",
Senior Scientist . . . Technologies :,
"Research Lead Computational Genomics , Research Staff Member . . Computational Life Sciences , Bioinformatics , Genomics , AI , Machine Learning , Software as a service , Cloud Computing , Data services and management , Analytics , Team Leadership , Planning and Strategy . Technologies :",
"Professor and Director . Member of the MHH Senate , Speaker of the professorial group 2011 2013 , 2015 2019 Member of the Board of Directors of the Centre for Structural Systems Biology , Hamburg Editor of FEBS Letters Editor of FEBS openbio . Dr. Dietmar Manstein is Professor and Chair of the Institutes for Biophysical Chemistry and Structural Biochemistry at Hannover Medical School . The objective of his work is the characterization of molecular motors and proteins that regulate dynamic changes of cytoskeletal and membranous structures . The coordinated generation of movement and force is essential for basic processes such as cell division , chromosome segregation , endocytosis , exocytosis , axonal transport , and muscle contraction . His experiments address the role of isoform specific differences , disease causing mutations , and drugs by integrating information derived from examining contractile events at several levels of organization . At the single molecule level , the work examines the basic design and function of the molecular motors , actin filaments , and regulatory proteins using highly sensitive and fast techniques to follow chemical , spectroscopic , and mechanical changes . These studies are usually combined with protein engineering and high resolution structural analyses . The determination of three dimensional structures of bio macromolecules and their complexes with small ligands is performed using X ray crystallography . The results of these measurements provide insights into the catalytic mechanism of enzymes , the mode of action of small molecule effectors , and support the development of therapeutic drugs . Hybrid approaches , which combine analysis by X ray crystallography with cryo electron microscopy or the analysis of hydrodynamic properties , are used to solve the structures of larger protein complexes . Here , the results can provide insights into long range communication pathways , regulatory mechanisms , and the effects of disease causing mutations . At the level of isolated cells , his research program uses the information gained from kinetic and structural studies , to address the role of proteins in supporting motile functions and the potential of small ligands as therapeutic drugs .. Technologies : Xray;CryoEM",proteins;characterization;engineering;interaction;structure
"Senior Scientist . . My favorite part of science is when big data meets big analysis . I m a PhD trained molecular biologist with extensive experience generating large scale genomic and proteomic datasets , but thanks to my additional background in engineering , I ve also developed the computational skillset needed to analyze these large scale datasets . As such , I m just as comfortable sitting at my lab bench pipetting reagents I need for an experiment as I am sitting in front of my computer trying to find creative ways to make sense of new data . Collaborations with others is also very important to me . Whether in academia or industry , generating and analyzing big data is always more productive and more fun when working with people who have different backgrounds and expertise than me . It s these type of collaborations that have provided me the opportunity to work on diverse projects , including investigating how genetic variants found across different populations contribute to human health and disease Fragoza and Das et al . Nat . Commun . 2019 , as well as uncovering new genes that may contribute to Autism Spectrum Disorder Chen and Fragoza et al . Nat . Genet . 2018 . I m always eager to share or learn about new and creative ways people are generating or utilizing biomedical data , so feel free to reach out if you ever want to chat . It may lead to another collaboration .. Technologies :",
"Director , Bioinformatics . Manage team of Bioinformatics Scientists responsible for analysis of viral genomes and antiviral drug resistance . Architect and develop GxP compliant software systems used to store and report sequencing results from clinical and discovery virology studies . Integrate biological assay data with patient demographics and clinical outcomes to enable correlation studies . Aid biologists with data mining , interpreting sequencing results , and data visualization Lead cross functional teams for submissions of datasets to FDA and international regulatory agencies for New Drug Applications and Drug Label Updates . Contributed to new drug approvals for treatment of SARS COV 2 Veklury , Hepatitis C Vesovi , Epclusa , Harvoni , Sovaldi , HIV Biktarvy , Genvoya , Descovy , and Stribild , and Hepatitis B Vemlidy and Viread . . Bioinformatics Team Leader responsible for development of software for clinical virology data reporting and data analysis strategies to support discovery and development of antiviral drugs . Specialize in building data pipelines for Next Generation Sequencing data analysis including de novo sequence assembly , sequence alignment , variant calling , and necessary quality control steps . Led bioinformatics projects for viral subtyping , antiviral resistance monitoring for clinical trials , vaccine immunogen sequence design , prediction of antibody sensitivity , and gene editing studies . Proven track record executing regulatory data submissions to US and other international regulatory agencies for new drug applications and clinical care quality measures : FDA , EMA EU , PMDA Japan , CFDA China , CMS Medicare Medicaid , and JCAHO . Led development of GxP software systems for reporting of clinical trial results based on FDA Guidance . Technical Expertise Programming Languages : Python3 , C , R , Proc SQL Database Development : Oracle , SQL Server , MongoDB Data Visualization : Matplotlib , Seaborn , Spotfire Cloud Platforms : AWS and Azure Web development : Flask , Jinja , RESTful services , .Net Web Forms Unit Testing : Python unittest , MSTest Source Code : Git and SVN Sequence Technologies : Illumina , Pacific Biosciences , Oxford Nanopore Phylogeny : FastTree , Garli , Phyml , Mega , FigTree . Technologies :",
"Cryo electron microscopy scientist . I currently work in a cryo EM core facility in Finland . My main duties are as follows : Preparing biological samples Plunge freezing and VitroJet Communicating with researchers about their projects and objectives Microscopy operation , Talos Arctica TEM Data collection and delivering results to researchers . I am passionate about microscope and imaging . Having seven years work experience in different types of electron microscopy and light microscopy , I work in an inspiring multidisciplinary team , giving cryo electron microscopy cryo EM services to university researchers and bioimaging communities . I have been lucky to complete my master 's and Ph.D. studies in renowned EM core facilities at Ghent University and University of Helsinki , where I gained advanced hands on skills in modern microscopes and imaging techniques . I have a strong interest in advanced imaging techniques , and I always search for new possibilities to expand my knowledge in microscopy . In the future , I want to become a senior electron microscopy scientist .. Technologies : CryoEM",structure
Bioinformatics Analyst 2 . . Computational Biologist Data Scientist . Technologies :,
PHD Researcher . . . Technologies :,
"Director , Cancer Immunology and Immune Modulation . Lead a group looking to discover novel cancer therapeutics which modulate the immune system to eliminate cancers . Special focus on combination therapies with oncolytic viruses and cargos for viruses . . Effective leader for biologics and NCE projects in respiratory , cardiovascular , oncological and neurodegenerative indications Conceived and executed the use of nintedanib in IPF , leading to a registered treatment for IPF , a previously untreatable orphan indication achieved blockbuster status in 2017 Co invented two innovative drugs , nintedanib for IPF and idarucizumab dabigatran antidote , now designated Breakthrough Therapies by the FDA Extensive experience in research and early development phases of multispecific biologics , scaffolds , antibodies , antibody fragments and peptide conjugates Worked in both biotechnology and pharmaceutical industries Solid scientist with over 7000 citations in peer reviewed drug discovery related fields and numerous granted patents Specialties : Inventing novel concepts to treat human disease Solving tricky problems Discovering new science and helping lead teams of scientists to do the same Enjoys working in multidisplinary teams NCE and Biologics drug discovery Biopharmaceuticals ; Biotechnology Assessing scientific opportunities . Technologies :",antibodies;developing
"Senior Research Engineer . Structural biochemical characterisation of type 4 secretion systems T4SS in gram positive bacteria . T4SS are large protein machineries that allow bacteria to exchange proteins and DNA , thereby leading to a spread in antibiotic resistance which is one of the major health problems world wide . . I have a PhD in biochemistry and am working as a senior research engineer at Ume University , Sweden . My research is currently focussed on a transport system Type 4 secretion systems that bacteria use to spread antibiotic resistance and virulence factors . General skills : I have experience in writing , public speaking , supervision , teaching , creative thinking and literature research . I am used to set up and optimize new methods and can work precisely and independently , but prefer to work as part of a team . I have also been active in various Science Outreach programs such as Forskarfredag and Soapbox Science . Laboratory skills : Cloning , optimization of expression and purification of membrane proteins and protein complexes from Escherichia coli , Saccharomyces cerevisiae and Lactococcus lactis . Protein reconstitution in proteoliposomes and nanodiscs . UV VIS absorbance spectroscopy , protein ligand binding transport studies and a wide variety of other protein activity assays . Currently doing more and more structural biology via both X ray crystallography and cryo electron microscopy .. Technologies : Xray",membrane proteins;structure
"Professor . . Structural biology of protein complexes involved in cancers , protein amyloids Tau , prion , A , TMEM106B , etc . in neurodegenerative diseases , viruses , and structure guided drug discovery using cryo electron microscopy cryo EM ; Developments of new sample preparation , data collection , and image analysis 3D reconstruction algorithms and software for single particle cryo EM , correlative light and electron microscopy CLEM , and electron tomography ET .. Technologies : CryoEM",idps;proteins;small molecules;structure
"Senior Scientist Drug Product Development . . Biochemist biophysicist with strong analytical skills and extensive research experience in protein peptide characterization using a wide array of biophysical and biochemical techniques . Specialties : Protein characterization , Protein analytics , Protein purification , Protein folding , misfolding and amyloid formation , stability , formulation . Technologies :",idps;peptides;proteins;characterization;formulation;stability
"Senior Scientist . . Computational Biologist Data Scientist Machine Learning Engineer with 10 years experience in software development , data modeling , statistical analysis , and machine learning . Key tech skills : Python machine learning packages , PyTorch , Keras , Time Series Analysis , Natural Language Processing , SQL , R , PySpark , C , Java , Javascript , openMP , MPI , Git , Flask , REST API . Bioinformatics : Rosetta , Modeller , Amber , Gromacs , PyMol , Schrodinger , Tophat , Cufflinks , DESeq2 , Kallisto , and Salmon . Email : mails2rojan gmail.com . Technologies :",
"Senior Scientist . Acting project lead Alzheimer 's drug discovery July 2021 February 2022 . Project lead biologics drug discovery February 2022 present . Research on disease modifiying treatments for Parkinson 's disease and Alzheimer 's disease in early discovery to late pre clinical phase . Focused on biomarkers and development of immunoassays and cell based assays . Participating in working group for company 's long term biomarker strategy . . Neuroscientist experienced in immunoassays , biologics drug research , live cell microscopy and receptor signaling , with a strong track record in method development . I am driven by a true passion for robust and potentially life changing science , and get my energy from great team work and challenging problems . I have research experience from both Sweden and the USA , and have gained knowledge on both in vitro and in vivo pharmacology during these 10 years . An open mind and efficient prioritization combined with diligence and endurance were key to reach my goals . Colleagues value my positive , cooperative personality , dedication and open and honest communication .. Technologies :",idps
"Postdoctoral Research Fellow . Mitochondrial diseases , Cryo electron microscopy , Dynamin related protein . . Technologies : CryoEM",proteins;structure
"Lab . Manager Molecular Biologist . . Have an extensive track record on membrane protein , protein characterization , protein crystallography as well as enzyme production in different expression systems . Besides , have vast knowledge and experience on Enterobacteriaceae and antibiotic resistance . . Technologies : Xray",membrane proteins;structure;characterization;expression
"Director . Director , Membrane Protein Sciences . . Technologies :",
"Scientist II . Molecular biology team leader , developing reagents to support multiple drug discovery projects from target validation to CSP . Development of expression constructs , stable cell lines and bacmam viruses . Highthroughput and targeted Taqman gene expression analysis to identify potential clinical and preclinical biomarkers and assess the validity of surrogate cellular models . Assay support for small molecule projects . New target assessment . An accomplished Research Scientist with 16 years experience in pharmaceutical drug discovery across multiple therapeutic areas , having broad knowledge and experience in research project management , leadership , problem solving , small molecule and monoclonal antibody research . Very broad appreciation of major disciplines in drug discovery with significant experience in pharmacology , cell biology , biochemistry and molecular biology , applied to both small molecule and monoclonal antibody research . Excellent people manager committed to the development of direct reports as well as providing leadership for colleagues across multiple global sites and disciplines . . Well developed networking skills , with proven team and leadership competency in global multidisciplinary programs and external collaborations . Extremely wide range of transferable technical and scientific skills enabling delivery across multiple therapeutic areas . Specialties : Molecular Biology , Assay development , Project leadership in small molecule and monoclonal antibody research . Technologies :",antibodies;proteins;small molecules;expression
"Assistant Professor at University of Michigan , College of Medicine . . I am an Assistant Professor of Pharmacology at University of Michigan Medical School , and my research is focused on the elucidation of the molecular mechanisms of GPCR activation , signaling , and regulation as well as exploiting the molecular tools modulating the GPCR signaling . I have a strong background in biochemistry and structural biology and have expanded my expertise to biophysics and protein engineering during my postdoctoral period . As an experienced researcher in the field of GPCR structural biology , I laid the groundwork for the structure determination of the active state GPCRs in complex with downstream G proteins by developing an antibody fragment , scFv16 , that stabilizes the GPCR G protein complex and chimeric G proteins to impart the binding of this antibody . These molecular tools have greatly facilitated structural analysis of numerous GPCR G protein complexes across the community such as mu opioid receptor , cannabinoid receptor , and chemokine receptors by cryogenic electron microscopy . I utilized it to reveal the molecular architecture of muscarinic acetylcholine receptior 2 Go type G protein and muscarinic acetylcholine receptor 1 G11 type G protein to reveal the structural framework of G protein subtype selectivity within muscarinic receptors . In addition , I succeeded to reveal the molecular basis of the extremely high subtype selectivity of muscarinic toxin 7 , a natural snake toxin , to the target receptor muscarinic acetylcholine receptor 1 by X ray crystallography . Using my protein engineering skillset , I engineered the interface of the toxin to redirect the specificity toward another muscarinic receptor , while retaining the conformational selectivity to the inactive state and allosteric effect on the antagonist . This study demonstrates a promise of the toxin scaffold to generate novel protein molecules with unique function . These research works wouldn t have been possible without a highly collaborative team , and I recognize a crucial importance of bilateral communication between team members with different research background for the success of the project . I also realize that layers of discussion among interdisciplinary teams not only polishes the output of the project but also creates a novel view and direction for the project .. Technologies : Xray",membrane proteins;interaction;structure
Marie Sklodowska Curie Research Fellow . Functional Lipid Interactions within Membrane Proteins . . Technologies :,membrane proteins;interaction
"Scientist , Computational Biology . Scientist on the Informatics and Predictive Science Team , focusing on cancer research . I focus on variational inference in the realm of computational biology . Current Master 's Student in Computational Biology at Weill Cornell . It 's a bayesian world , frequentists are just living in it . Technologies :",
"Assistant Director New Antibody Products . . I am really passionate about performing scientific experiments that may contribute to the understanding , improvement and instigation of cancer treatments . . Technologies :",antibodies;developing
"Senior Scientist : Cresset Discovery . . PhD in Chemistry from IISc Indian Institute of Science , Bangalore , India . MBA in General Management from SIMS Symbiosis Institute of Management Studies , Pune , India . MSc in Organic Chemistry from Bangalore University , India . BSc with Physics , Chemistry and Mathematics from Bangalore University , India . Post Doctoral Fellow in Max Planck Institute , Muelheim , Germany which focused on novel catalyst design for Waker Chemi , Munich , Germany . Post Doctoral Fellow in the College of Pharmacy , University of Michigan , USA , which focused on protein modelling , docking and protein flexibility in Drug Discovery . Collaborative work experience with global pharmaceutical leaders AbbVie USA , MSD USA , Orion Finland , Takeda Japan , Novo nordisk Denmark , Debiopharma Switzerland , Inflazome UK and Grey Wolf Therapeutics UK on disease targets like Diabetes , Cancer , Obesity , Inflammation Alzheimer 's . Experienced in setting up State of the art 3D Computer Aided Drug Discovery laboratory . Power user of QM , MD and MM softwares like Spartan , Gaussian , Molsoft ICM , Schrodinger suite , MOE , OpenEye Suite , AMBER , GROMACS , PyMOL , VMD , SILCS FragMaps ; Product development , Leadership , Start up , Business Development , Health care and Crop Protection , In Licensing and Out Licensing , Fine Chemicals , Bulk Manufacturing , 3D Visualization and Modelling . 10 publications in international Journals . Inventor ship on 66 published or filed US and World patent applications and granted patents . Excellent analytical and communications skills with familiarity with pharmaceutical space . Associated Institutions : 1 Indian Institute of Science , Bangalore , India . 5 years in campus 2 University of Michigan , Ann Arbor , USA . 2 years in campus 3 Max Planck Institut f r Kohlenforschung , Muelheim , Germany . 2 years in campus 4 Bangalore University , Bangalore , India . 5 years in campus 5 Bioinformatics Institute BII , Singapore . 2 years in campus 6 Singapore Eye Research Institute SERI , Singapore . 2 years in campus 7 Symbiosis institute of Management Studies SIMS , Pune , India . 2.5 Years in campus . Technologies :",
"Research Fellow , Computational Biology . . . Technologies :",
Scientist Bioinformatics . . . Technologies :,
"Research Scientist . . My research focuses on developing chemical tools to study protein function , and elucidate their role in relation to health and disease . Utilizing my background in organic synthesis and medicinal chemistry I have hands on experience within multiple projects including development of both small molecule and peptide based probes , development and SAR studies of inhibitors and PROTACs as well as enzymatic assays , protein pull down , and cell culture .. Technologies :",molecular glues;small molecules;peptides;developing
"Ramalingaswamy Fellow of DBT and Faculty Scientist . Responsibilities include elevating genomics research in India in par with that in the West through training and research . My research projects include but not limited to : Studying alternative splicing in eukaryotes . Discovering biomarker for cancer using public repository of NGS data . Sequencing the genome and transcriptome of Amaranthus hypochondriacus to decipher lysine metabolic pathways in plants . Providing scalable solutions to individual investigators on cloud to maximize use of RNA seq data in the public repositories to advance research . . I have dedicated my career to applying computational solutions to solve simplify complex biological problems ranging from protein folding to personalized genomics . My current focus is in applying information from the post genome sequencing efforts to improve human health via personalized genomics and molecular breeding . Authored over 40 publications in peer reviewed journals including a book . Inventor of over 10 issued US patents involving development and application of novel algorithms for solving complex biological problems . Demonstrated ability to turn white board level concepts to marketable research tools for use in biomarker or drug discovery efforts . Specialties : Developing novel algorithms , implementing new ideas to solve bottom line problems , developing products , building scalable business model , forging collaborations , raising funds , developing marketing strategies , securing NIH grants , providing customer support , software solutions , training students . Technologies :",
"Permanent scientist Institut Pasteur . . Researcher in Cell biology , , Virology and Cryo CLEM and tomography , with experience in the coordination and development of scientific projects . Passionate for cryo EM advanced methods development . Excellent communication and networking skills . TECHNICAL EXPERTISE : Animal models . Mouse : E18 Dissection hippocampus and cortex . Zebrafish : cdna et mRNA micro injection . Transplantation . Live imaging of Zebrafish embryos in gastrula stage . Biochemistry and Molecular Biology . Bacterial transformation . Restriction enzyme digestion . Molecular cloning , including mRNA amplification . DNA preparation including plasmid , genomic PAC DNA . Immunoprecipitation . Polyacrylamide gel electrophoresis . Western blot . Pkdigestion , velocity gradient . CRISP CAS9 . Immunofluorescence . Wholemount zebrafish staining Culture systems . Mammalian cell lines : SHSY 5Y , CAD , MDCK , GT1 , N2A , FRT , HeLa , HEK 293 . Primary cell cultures : Cortical , hippocampal neurons , organotypic slices . DNA transfection , Lentivirus Transduction , RNA interference . Primary cell culture from embryos of zebrafish in gastrula stage . Cell culture Infection with SARS CoV2 Software and Image Analysis : ImageJ , ICY , Imaris , Adobe Premiere , Adobe Photoshop , Adobe Illustrator , Amira , Serial EM , Excel , Powerpoint , Prism6 . Microscopy . Light fluorescence microscopy : Zeiss and Leica confocal microscopy . Spinning Disk Nikon ; Cryo Electron Microscpy Tecnai 20,Thermo Fisher company , and Titan application to EMBL ; Light Sheet Microscopy and AO Light sheet , application at Janelia labs Cryo electron tomography on a TITAN CRYO EM Cell preparation for Carbon coated gold TEM grids Cryo EM samples preparation Cell Vitrification using LEICA EMGP system Cryo Fluoresence Animal Licenses Rodents .. Technologies : CryoEM",proteins;structure
"Principal Scientist . Structure based drug design ADC project support . Experienced Associate Professor with a demonstrated history of working in the higher education industry . Skilled in Natural Products , Cheminformatics , Medicinal Chemistry , Biotechnology , and Chemical Biology . Strong education professional with a Ph . D focused in medicinal chemistry from Shenyang Pharmaceutical University . . Technologies :",antibodies;developing
"Scientist , Structural Biology . Building a scalable cryoEM pipeline to accelerate drug discovery for GPCRs . . Excited about using cryogenic electron microscopy cryoEM to accelerate structure based drug design against challenging targets . Experienced in all aspects of the gene to structure pipeline including construct design , recombinant expression in mammalian cells , protein purification , sample optimization for structural biology , cloud computing , and model building .. Technologies :",membrane proteins;proteins;small molecules;structure
"Researcher . . My main interest is the elucidation of virus host interactions . I am applying classical molecular virology in combination with fluorescence microscopy , cryo electron microscopy and functional genomics approaches to gain a deeper understanding into viral life cycles . Apart from basic virology , I also have a keen interest in wildlife medicine and one health . In addition to my research activities , I am involved in running a diagnostic laboratory and training teaching of under and postgraduate students . My main motivators are the quest for knowledge , problem solving and the optimisation of workflows and tasks . . Technologies : CryoEM",interaction;structure
"Process Scientist I . . Using biokinetic , mass transfer and mixing models to scale up CHO cell culture mAb processes from geometrically dissimilar bioreactors SUBs to very large scale commercial manufacturing bioreactors . modelling scale up mAbs . Technologies :",antibodies;expression
"Project Scientist . Chemistry , biomolecular simulations , numerical mathematics and IT : Method and software development for computer simulations of complex molecular systems . Developer of the AMBER molecular dynamics and ADF density functional program packages . . Scientific software developer bridging chemistry , physics , numerical mathematics and IT . Working with established and newly developed computational approaches to answer chemical questions . Experienced in teaching and student supervision at the university level . Interested in a career as leading scientist . Specialties : Fortran , Python , shell scripting , Git , MPI , performance libraries , high performance computing , GPU computing , computational chemistry , density functional theory , data analysis . Technologies :",
"Principal Scientist . . Experienced structural biologist focusing on ternary protein complex structures in Targeted Protein Degradation filed . Strong expertise in both X ray Crystallography and single particle cryo EM . Proven record in construct design , protein chemistry and protein ligand characterization . . Technologies : Xray;CryoEM",molecular glues;proteins;small molecules;characterization;interaction;structure
"' Interdisciplinary Cancer Research ' Fellow . Fellowship Programme , co funded by the EU Framework programme 7 FP7 Marie Curie Actions . Funded Project : ' Resensitisation of chemotherapy resistant cancer cells through selective inhibition of the STAT3 signalling pathway ' . Drug Discovery , biological evaluation and preclinical development of a novel class of small molecule STAT3 inhibitors , as stand alone agents and in combination with DNA damaging chemotherapy platinum based in paired sensitive and resistant cell lines , as a means to overcome drug resistance . Design and analysis of drug combinations . Elucidation of the molecular mechanism for the observed synergistic interactions , based on the modulation of DNA damage repair by STAT3 inhibition and the elicited DNA damage response in both 2D and 3D cultures . Identification of a lead compound as a potentially clinical candidate . Extensive comparative studies with the majority of commercially available STAT3 inhibitors , including those under clinical evaluation e. g. napabucasin , TTI 101 , WP1066 , repositioned agents and agents in the pipeline of clinical stage . biopharmaceutical companies . Detailed characterisation of cell signalling perturbations and effects on downstream target genes . Discovery of two unique differentiating properties of the lead compound . It is inherently . fluorescent and its cellular uptake can be traced by live cell imaging , confocal microscopy and or . FACS . It also induces in vitro , the morphological signatures e. g. vacuolisation of recently reported , . non apoptotic cell death mechanisms paraptosis methuosis . Filing of a US provisional and a PCT patent application . Development of a novel , colorectal cancer , 3D multicellular spheroid model , for the study of ICD signatures induced in vitro , by the First in class Ruthenium Anticancer Drug KP1339 BOLD 100 . Preparation of CDAs for use with industrial partners . . Supervision of 2 M. Sc projects and training of 10 visiting scientists internships . . Drug Discovery , Drug Development , biological evaluation and preclinical development in vitro , in vivo of novel , experimental cancer therapeutics . Molecular and cellular pharmacology toxicology of clinically used as well as novel , rationally designed DNA interactive agents DNA damaging : alkylating agents , DNA Interstrand crosslinking agents , Non covalent non genotoxic DNA binding agents : polyamides , Antibody Drug Conjugates and small molecule inhibitors molecularly targeted agents . . Development of biological assays for the characterisation of drug induced DNA damage and DNA repair cellular responses in various models cell free systems , yeast mammalian human cell lines , 3D tumour spheroids , xenograft samples , patients samples . . Characterisation of drug effects and interactions between DNA damaging chemotherapeutics radiotherapy and molecularly targeted agents in 2D and 3D cultures . Cellular uptake studies of platinum based and fluorescent drugs . Identification of synthetically lethal interactions . Expert in biological assays used for regulatory purposes Comet assay , H2Ax , DNA covalent binding assays , nuclear fragmentation . Immunogenic Cell Death inducers chemistry and biology . Development of a 3D spheroid model for . the in vitro study of ICD signatures . Training in Health Risk Assessment Karolinska Institutet , the interpretation of toxicological data Toxicogenomics EMBL EBI and Adverse Outcome Pathways AOPs , JRC EU Commission , UK National Centre for the Replacement , Refinement and Reduction of Animals in Research NC3Rs . 1 US provisional and one PCT patent application on a novel class of small molecule STAT3 inhibitors . . Mentoring and supervision of 3 PhD and 20 MSc students ; SOPs , Budget management of own research grant , organisation of seminars , workshops and international meetings . Scientific dissemination : 44 published papers , 1 book chapter , 1 review , 18 Abstracts , 1 AACR Scholar in training award , 3 Lectures , Extensive postgraduate teaching , Successful grant applications , Reviewer in various journals . . Technologies :",nucleic acids;proteins;small molecules;interaction;screening
"Principal Scientist . Formulation design and development . Formulation Techniques : Long acting injectable and oral formulation design : nanocrystals , micelles , liposomes , polymer drug conjugates , solid lipid nanoparticles and microspheres Formulation characterization techniques : particle size , charge , loading , stability , morphology , viscosity , surface tension and protein binding Lyophilization process development and optimization Skill of pharmaceutical applications of different stabilizers and excipients Nanoformulation subcellular trafficking and proteomics analysis Basic GMP GLP knowledge Analytical Techniques : High Performance Liquid Chromatography Liquid Chromatography Mass Spectrometry Gel Permeation Chromatography Ultraviolet Visible and Fluorescence Spectrophotometer Fourier Transform Infrared Spectroscopy Dynamic Light Scattering and Zetasizer Polyacrylamide gel electrophoresis Confocal Microscopy and SEM TEM Magnetic Resonance Imaging Cell and Animal Processing Skills : Basic cell culture technique Bioassay : Western blot , MTT , ELISA , PCR , and Immunohistochemistry Basic PK PD technique Jugular vein cannular technique Chemistry Techniques : Prodrug design and development Polymer modification Polymer drug conjugation Computer Skills : Molecular Modeling software Microsoft Word , Excel , PowerPoint and basic Internet skills Photoshop Adobe Illustrator AutoCAD EndNote Prism SPSS . Technologies : SLS DLS",antibodies;carriers;formulation;stability
"Assistant Professor . . I am passionate about using cryo EM to understand how macromolecular complexes function in human health and disease . Currently , I am a faculty member at the University of Michigan who leads a laboratory that studies mechanisms of microtubule trafficking . Our main technique is cryo electron microscopy that we supplement with single molecule fluorescence and biochemical assays . Research laboratory website : https : www.lsi.umich.edu science our labs michael cianfrocco lab . Technologies : CryoEM",proteins;structure
"Consutant . Advisor for younger academic and technician workers . RESEARCH PROJECTS ON : 1 . Oscillating Acoustic pressure experiments at frequency of around 1 MHz coupled with Raman and Fluorescence spectroscopy on a designed cell with protein solution for measuring fast protein folding . 2 . Focus : Construction of Iso potential surfaces of biomolecules from Quantum Mech . Calculations . 3 . ESR studies of Channel Proteins in membranes for investigating protein lipid interaction . 4 . Phase study of Bio mimetic membranes with respect to proteins and detergents . 5 . Electronic processes in the Photosynthetic complex . 6 . Studies of Surface Enhanced Raman Scattering . Research in quantum field theory and statistical physics in the first research years but has since been focused on biophysics . Here , the main field of research in the last 25 years has been molecular biophysics . Specifically , the particularly biomolecules of proteins are studied with respect of their structure , dynamics and biochemical function that are analyzed theoretically by computation methods using computer and measured experimentally by especially vibrational spectroscopy . Worked on Medical Informatics , e.g. searching for structures of HIV proteins . Recently I have undertaken an immunology project on tolerance of Tregs concerning organ transplantation using available experimental data and literature study of how to transfer Tregs to the patients of transplantation . Particular innovation activities have been starting and setting up the following activities and research collaboration with industry 1 . Prokyon Aps , for utilizing microwave radiation for biomolecules production and refinement H rsholm , DK , Closed 2008 . 2 . Structural Bioinformatics AT , a company with 12 researchers lab.tech . using Neural Networks in protein design . Bought . 3 . Consulting work and collaboration 2001 2015 with Novo Nordic , Novo zymes , Santaris Roche H rsholm and Lundbeck etc . Key words : Drug design , classical and quantum calculation of molecular structures . Technologies :",biologics;proteins;interaction;stability
"Assistant Professor . My lab specializes in using cryo EM to visualize how molecular machines enact protein quality control . . Cells have extensive quality control systems to correct various mistakes . Yet , quality control can also fail , leading to diseases such as cancer and neurodegeneration . My goal is to resolve the molecular detail of cellular quality control so we can understand 1 how cells normally stay healthy ; 2 how quality control fails ; and 3 how to rescue quality control failure . In the media : http : healthcare.utah.edu publicaffairs news 2015 01 1 01 15 New Function for Proteins.php http : healthcare.utah.edu publicaffairs news 2016 11 pkd2 silent killer.php . Technologies : CryoEM",proteins;structure
"VP Chemistry . . Experienced medicinal chemistry leader with a strong track record of clinical candidate delivery . VRx 3996 atinostat , AZD5363 capivasertib GSK3117391 . Accomplished manager director of CRO chemistry teams . Expertise in property based , SBDD FBDD . Additional expertise at the interface of medchem and compchem . Strong focus on project delivery and managing medchem strategies . . Technologies :",small molecules;interaction;screening
"Principal Scientist Mass Spectrometry in PAT . Providing mass spectrometry support to Commercialization MMD in line , at line online . . As an accomplished leader in Mass Spectrometry and analytical chemistry , I have end to end experience from small molecule drug discovery to clinical trials and vaccine licensure . My extensive background has enabled me to successfully apply innovative analytical approaches to solve complex problems in a variety of fields . Where others see challenges , I see opportunities to challenge the status quo and implement positive changes for better scientific outcomes . My goal is to use my analytical knowledge and leadership skills within a diverse laboratory setting to solve problems and deliver quality results , while providing mentoring and coaching of technical and emotional intelligence to less experienced staff . Specialties : Applying analytical chemistry to resolve issues . Recognized expert in chromatography , automation and mass spectrometry . Applied mass spectrometry techniques to extractables and leachables , metabonomics , ion mobility , affinity selection , peptides , proteins , nucleotides , antibody drug conjugates , reaction monitoring TLC MS and ambient ionization techniques .. Technologies :",
Bioinformatics Manager . . . Technologies :,
"Director Of Operations , SCSC . . Electron Microscopy Cryo ET Cryo EM Array Tomography SEM 3D Volume SEM CLEM Correlative Light and Electron Microscopy Variable Pressure VP SEM application Hydrogel and Biomaterial Imaging Synchrotron XRF application to Biology EM Technique Development SEM and TEM Visualization : Light and Electron Microscopy Microbial Biofilms Bio energy Plant and Microbial Sciences and Interfaces Monoterpene Essential Oils Metabolism Gas chromography Complexity Theory and Fractal Analysis Biology Teaching in Higher Education Specialties : Electron Microscopy Imaging Techniques Biofilms Biofuels Assay and Protocol development . Technologies : CryoEM",
Scientist I Computational Biology and Machine Learning . . I 'm a recent Computational Biology PhD graduate from MIT . I 'm passionate about making sense of large multi modal datasets and using those insights in translational settings . My graduate work consisted of developing and applying graphical and machine learning algorithms to integrate large sequencing datasets and understand the causes of ALS .. Technologies :,
"Computational Biologist . . I am a data scientist and statistician working in the field of genomics and transcriptomics . I am currently a computational biologist in Biogen . I am working on developing statistical and machine learning methods for applications ranging from bulk DNA RNA sequencing , scRNA seq data , and multi omics data integration . I was a postdoctoral fellow in the Department of Bioinformatics Computational Biology , The University of Texas MD Anderson Cancer Center . I have formal training in mathematics , biomedical engineering and statistics . I obtained Bachelor degree in Applied Mathematics at Xi an Jiaotong University in China , 2011 . I obtained PhD in Biomedical Engineering at Tulane University on 2016 .. Technologies :",
"VP , Digital Lab Systems . . Bioinformatics experience 20 years at industry leading institutions Strong project , management , communication , and organizational skills Management and control of large budgets up to 2 million Management of large staff up to 20 people including developers and system administrators Extensive software design and development experience Infrastructure design , development , and implementation Application of software engineering methodologies Ability to work on multiple concurrent projects Ability to communicate with all levels of an organization Specialties : Informatics Functions : Systems analysis , Project management , System administration , Network administration , Database administration , Website administration , Software development Domain knowledge : Next generation sequencing , Genetics , Proteomics , LIMS Bioinformatics Software : CASAVA , BWA , BFast , GATK , TopHat , Bioconductor Programming Languages : Perl , Ruby , PHP , SQL Oracle , Sybase , MYSQL , JAVA Operating Systems : UNIX Solaris , Linux , Microsoft Windows , Macintosh High performance computing : Moab Torque , high performance storage , large compute clusters . Technologies :",
"VP Research , Pharmacokinetics and Drug Metabolism . . . Technologies :",
"Lead Staff Scientist , DNA Origami Research . Lead the design and the development of DNA Origami reagents for single protein detection platform . I 'm a bioengineer and software developer specialized in DNA origami design and protein engineering . I develop DNA origami tools for various biological applications including high throughput cryo EM studies of small proteins and RNAs . I also develop software that aid in DNA origami and protein design , and for cryo EM image processing .. Technologies : CryoEM",
Visiting Researcher . . Utilizing correlative super resolution light and cryo electron microscopy to investigate the role of endolysosomal pathways in the intracellular delivery of therapeutics .. Technologies : CryoEM,carriers;structure
"USP DSP Scientist . at MSD Oss . Experienced Biomedical Engineer with a demonstrated history of working in the pharmaceuticals industry . Skilled in Upstream Processing , Monoclonal antibody production , Cell culture , Cell biology , Bioreactor technology and Lab automation . Strong research professional with a Master of Science MSc . Technologies :",biologics;expression;quality
"Research Scientist . . Molecular biologist with proven expertise and 13 years of experience in biochemistry molecular biology chemical biology structural biology research . Now determined and exploring opportunities to learn , lead and excel in industrial set up . I have identified , explored and established functions of several noble proteins and the signaling molecules involved in RNA damage and repair and , bacterial defense against phage . Demonstrated expertise in a Protein biochemistry : protein cloning , expression , biochemical studies and , structural studies using SPR , X ray crystallography and Cryo EM . b NGS : RNA Seq library preparation and data analysis . Proven ability to work , train , and lead the team to achieve projects goal on time . I had great experience working with and leading people from diverse background . I have planned , executed , troubleshoot and successfully finished projects within deadline in team set up and alone . Contributed to multiple articles and grants writing which were funded .. Technologies : Xray;CryoEM;SPR",proteins;interaction;structure
Bioinformatics Analyst III . . . Technologies :,
"Staff Bioinformatics Pipeline Development Engineer . . Bioinformatics Applications 1 TNBCtype : A subtyping tool for triple negative breast cancer . https : cbc.mc.vanderbilt.edu tnbc 2 MitoSeek : A tool to perform high throughput mitochondria sequencing analysis.https : github.com riverlee MitoSeek . 3 RNASeqDEPipeline : A integrated pipeline to perform RNA Seq differential gene expression analysis . https : github.com riverlee RNASeqDEPipeline . 4 ViewFusion : A visualizing tool for gene fusions . https : github.com riverlee viewFusion . 5 DOSim : An R package to calculate similarity between diseases based on Disease Ontology . http : cran.r project.org web packages DOSim index.html . 6 DO.db : A set of annotation maps to describe the entire Disease Ontology . http : www.bioconductor.org help bioc views release data annotation html DO.db.html . 7 Risk FunmiRSNP : A web based tool to detect , analyze and annotate disease risk miRNA polymorphisms from large scale dataset . http : 210.46.85.150 platform riskfunmirsnp . Skill set Computer skills Operating Systems : Linux , Mac OS , MS Windows . Programming Languages : Perl , R , Java , Shell , Python , Matlab . Database and Web programming : Apache MySQL PHP , Ajax , Drupal , Joomla , jQuery . Others : Wiki , Sweave , Bioconductor , Bioperl , Weka , Spider , Cytoscape , Illustrator , and Latex . Bioinformatics skills Next Generation Sequencing Analysis : Reads Quality Control , Mapping and Evaluation , Gene Expression Quantification and Gene Fusion Detection for RNA Seq , Peak Calling , Annotation and Motif Analysis for Chip Seq , Variants Detection and Functional Prediction for Exome Seq , Peak Calling and Footprint Analysis for ATCT Seq . Microarray Analysis : Differential Expression and Co expression Network Analysis . Machine learning techniques : Classification SVM , KNN , Decision Tree , Clustering . Statistical analysis : Linear Regression , Survival Analysis , and Principal Component Analysis PCA . Genetics Analysis : Genome Wide Association Study GWAS , Hardy Weinberg Principle Testing .. Technologies :",
"Principal Scientist . . 20 yrs experience in biophysical characterization and stability evaluation of proteins . During the last 15 years my research activities have been related to early stage biopharmaceutical drug development including antibody format variant screening . Experienced in identification of mAb variant selection criteria related to stability and biophysical properties , as well as in formulation screening for optimized stability and viscosity profiles . Collaborative across drug development areas : Discovery engineering , early CMC analysis and formulation , patent , and clinical teams .. Technologies :",antibodies;biologics;proteins;characterization;formulation;stability
"Founder and Director , Centre for Targeted Protein Degradation CeTPD . . . Technologies :",molecular glues;interaction
"Senior Scientist . . Biophysicist structural biologist with 10 years of research experience . I am interested in studying the structure function relationship of ion channel and membrane transporters using a multitude of techniques including X ray crystallography , Cryo electron microscopy and Molecular dynamics simulation . Proven track record in teaching , mentoring , and leading scientific collaborations .. Technologies : Xray;CryoEM",membrane proteins;structure
"Principal Scientist CMC USP and Host Creation . . I am passionate about Biotechnology and the production of next gen therapeutics . I am currently engaged as a Principal Scientist CMC Host Creation and Upstream processing . In addition to managing day to day CMC activities within these skill teams , I am also involved in managing the CMC Nanobody development activities and tech transfer . From my academic experience , I have a strong background in Recombinant protein production strain engineering , expression optimization , protein purification and characterization , Molecular Biology and Glycobiology . I am a research professional with a strong drive to learn and integrate new technologies , always eager to take on new challenges . . Technologies :",antibodies;characterization;developing;expression
"Head Preclinical Product Development . More than 25 years of experience in development of antibodies from research till clinical phase II studies . Actively involved in the start up of several biotech companies . At Ablynx I was the first employee , and project manager for the discovery and pre clinical early clinical development of Caplacizumab . Caplacizumab is approved as a first in class treatment for acquired thrombotic thrombocytopenic purpura aTTP . This project resulted to the acquirement of Ablynx by Sanofi for 3 . 9 billion euros . At argenx I was also one of the first employees and project manager for the discovery and pre clinical clinical development till phase I of Cusatuzumab . This project entered an exclusive global collaboration and license agreement with Cilag GmbH International , an affiliate of Janssen . Cusatuzumab is currently in development in combination study with Vidaza for newly diagnosed , elderly patients with acute myeloid leukemia AML and high risk myelodysplastic syndrome MDS who are unfit for chemotherapy . . I was also project leader for ARGX 117 , ARGX 119 and ARGX 120 . Currently I am heading all preclinical programs from lead optimization till IND submission . At Staten I did the discovery and helped with the pre clinical development of STT 5058 , a monoclonal antibody targeting Apoc3 . This antibody entered into a collaboration with Novo Nordisk who provides funding and support for Staten to develop its lead asset STT 5058 for treatment of dyslipidaemia . . At Catalym I was SVP for CMC , bioanalytics and toxicology . I worked for four years at the university of Brussels developing the Nanobody platform which lead to the establishment of Ablynx , where I was the first employee . I was inventor and project leader for Caplacizumab , the first and only Nanobody approved today . . After that I joined argenx where I was project leader for ARGX 110 , ARGX 117 , ARGX 119 and ARGX 120 . I work since 4 years as an independent consultant supporting argenx , Citryll , Catalym and Staten with the preclinical development of their antibodies . . Currently I am heading all preclinical programs at argenx taking antibodies from lead optimisation until IND filing . . Technologies :",antibodies;developing
"Visiting Junior Researcher BioLAB Program . Project : Solving the structure of IGF 1 : IGFBP 3 : ALS complex using cryo EM My one year internship work is devoted to assembling IGF 1 : IGFBP 3 : ALS ternary complex , and using cryogenic electron microscopy and RELION to solve its structure . Methods : Cryo EM , protein purification , protein refolding , HEK cells culture , Sf 9 culture , bacteria culture , Western blotting , site directed mutagenesis PCR . . On the verge of science and business . Success driven scientist with an entrepreneurial mind and deep interest in business . Excellent problem solving and project management skills . Proved both as a team player and a leader . Seeking to utilise my scientific background and further develop my business acumen . Specialized in bioinformatics and structural biology .. Technologies : CryoEM",proteins;structure
Principal bioinformatics research scientist . . . Technologies :,
"Digital Research Environment Lead . . PMP certified Project Manager with extensive experience in Biomedical Informatics led multi disciplinary teams across global sites . Successful collaborations with partners customers in academia and industry . Expertise in translational informatics , genomic and NGS data management , integration , visualisation and analysis . Particularly interested in the advancement of translational research to improve diagnostics and treatment of patients . Specialties : Project Programme management and team leadership Biomedical informatics strategy and systems linking clinical and genetic omics data Bioinformatics , cancer genomics and Next Generation Sequencing NGS External collaborations with partners customers User interfaces and visualisation . Technologies :",
"Scientist . . I have a broad scientific profile from my Nanoscience Education and Ph.D. in an interdisciplinary group , combining nanomaterials with protein chemistry and biophysics . My research interests are in the field of G protein coupled receptor GPCR biology . In particular , I find it fascinating how new insights in receptor function can guide rational drug design for the development of novel pathway selective compounds with reduced side effects . My expertises are within quantitative characterization of GPCRs using fluorescence detection methods and surface sensitive techniques such as Surface Plasmon Resonance . I m motivated by starting up and developing new and innovative ideas ; with this positive mindset , I established methods for GPCR purification , stabilization and characterization in our laboratory by visiting and transferring know how from collaborators in USA and Europe . Technologies : SPR",membrane proteins;small molecules;characterization;interaction
"Co founder Managing Director ATEM Structural Discovery . ATEM Structural Discovery provides innovative cryo EM solutions to pharmaceutical and biotechnological industries . We support the most challenging discovery and quality control efforts and allow the structural elucidation of previously unfeasible drug targets . . A cryo EM Scientist , founder and technology enthusiast focused on innovating method development and advancing the most powerful , fully integrated cryo EM platform in the pharmaceutical and biotechnological industry with ATEM . At the forefront of leveraging the powers of cryo EM to understand how macromolecular complexes and proteins function , malfunction in disease and how they interact with small molecule or biological drug candidates . Develops an integrated cryo EM platform to extract more empirical data from highly complex 3D structural models . Published in top peer reviewed journals Science , Nature , and Cell ATEM is at the forefront of the cryo EM revolution in structural biology . Our unique and integrated platform incorporates cryo EM optimised biochemical processes with high end data acquisition hardware and data processing augmented by continuous machine learning enhancements . Our next gen proprietary software suite allows us to deliver more detailed , high resolution 3D structural models with higher accuracy and faster turnaround times . To find out more about ATEM , visit our website at : www.atem.bio or contact me at karl.bertram atem.bio . Technologies : CryoEM",small molecules;interaction;structure
"Ph.D. Researcher . Reconstitution of Cell Polarity and Morphogenesis . . I am a researcher with experience in experimental and computational biology . My interest lies in the development of cell based diagnostics and therapeutics . I believe , with the current advances in protein engineering and genetic circuit design , we can repurpose cellular functions to sense molecular markers and selectively actuate therapeutic response against diseased cells . With this aim , I aspire to pursue a career in the field of Synthetic Biology .. Technologies :",
"Senior Scientist Computational Biology . Analysis of high throughput sequencing data directed at clinical biomarker identification and understanding mechanisms of resistance to targeted therapy in an oncology setting . NGS data analysis pipeline development for variant calling and transcriptomic analysis utilizing tools such as GATK , varscan2 , bwa , bowtie , RSEM , muTect , etc . Development of models utilizing gene expression profiling for identification of prognostic biomarkers and response to ibrutinib . Genomic copy number SNP analysis of data from clinical samples . Secreted protein analysis from patient serum . Longitudinal analyses in support of establishing clinical biomarkers for future studies . Established a computational infrastructure in support of bioinformatics . Computational chemistry MD simulation , free energy perturbation , virtual compound screening , docking in support of new compound discovery and lead prioritization Interacting closely with clinical operations as part of study management teams . Selected Commercial Tools and Programming Languages : C , Perl , and R programming in a Unix Linux environment ; NGS data analysis pipeline development using tools such as GATK , Varscan2 , bwa , RSEM , MuTect , bowtie , etc . ; Integrative analysis using OmicSoft ArrayStudio , Schrodinger Suite ; relational database design and management , SQL ; Proteomic data analysis : Progenesis , Scaffold Sorcerer , Crux ; VMD NAMD molecular dynamics and modeling software ; visualization of high dimensional data sets ggobi and others ; Statistical analyses using JMP , Partek ; Automation and high throughput software development .. Technologies :",
"Scientist Vaccine Development . . Dedicated , self motivated , flexible , quick learner and deadline driven biotech professional with extensive training in upstream process development and production cell culture , cell biology , bioassay as well as downstream process development and production protein purification , antibody purification , biochemical and biophysical characterization in academic setup . I have obtained intensive 5 days long in person training on industry standard GMP compliance .. Technologies :",antibodies;biologics;characterization;stability
Research Professional . . My interests are centered on studying the structure function relationship of macromolecules . I employ X ray diffraction methods and Cryo electron microscopy to gain understanding of the structural basis of the mechanism of action of and inter relationships of biological macromolecules .. Technologies : Xray;CryoEM,proteins;structure
"Scientist . . Graduate student peptide chemist with 4 years of experience in short to medium length 20 50 amino acids long peptide synthesis , purification , characterization and self assembly analysis . Skilled in automated solid phase peptide synthesis SPPS , preparative and analytical high performance liquid chromatography HPLC , matrix assisted laser desorption ionization time of flight mass spectroscopy MALDI TOF MS , instrument maintenance , UV Vis and fluorescence spectroscopy , circular dichroism spectroscopy , transmission electron microscopy TEM , cryogenic electron microscopy cryo EM , X ray diffraction XRD .. Technologies : Xray;CryoEM;CD",peptides;characterization
"Advanced Workflow Specialist Nanotechnology . Training and workflow design for electron microscopy experiments . . Currently providing training and experimental design for electron microscopy , including sample preparation methods , at Leica Microsystems . My postdoctoral work at the National Institute for Neurological Disorders and Stroke NINDS focused on synaptic vesical trafficking with room temperature TEM and HPF sample preparation . During my doctoral training at Case Western Reserve University , I studied macromolecular structures with cryo EM and molecular dynamics simulations .. Technologies : CryoEM",proteins;structure
"Principal Research Scientist . In Department of Protein and Peptide Biophysics , I 'm have implemented and optimizing our state of the art automation platform for high throughput biophysical characterization of proteins and peptides . The automated platform integrates all steps from liquid dispense , incubation , analytical instruments and data analysis , required for efficient high throughput biophysical analysis of protein formulations . I am involved in a number of diabetes related projects , where I employ techniques such as MFI , DLS , ThT fluorescence , SEC HPLC and CD spectroscopy to guide selection of improved API protein candidates and the development of stable formulations . . I consider myself a multidisciplinary biotechnology professional capable of tackling a variety of challenges in biotechnology and biophysics . In addition , I have a strong background in computer programming Python , Javascript , C , VB.net , Delphi , Java and Assembler , which I have used to develop software for rapid analysis of organized data , Lab Automation , and automated computer vision analysis of animal model behaviour . My academic career has been focused on study protein folding , misfolding and aggregation . I have a solid foundation in molecular biology from my masters where I developed Phage Display techniques for directed evolution of proteins with increased folding stability . I have strong expertise in protein biophysics from detailed doctoral studies of Amyloid like protein fibrils using glucagon model system . An lastly , I have a detailed knowledge about the genetic pathways of aging and aging related diseases from studies on the roundworm C. elegans as well as strong expertise in the use of various microscopy techniques from my post doctoral studies in the Morimoto lab at Northwestern University . At the small biotech startup , ilochip A S , I was working with an interdisciplinary team of engineers and scientists to develop a generic device for genetic detection analysis of airborne pathogens . I found this combination of molecular biology , electrochemistry , micro fluidics , electronics and computer software to be a very interesting challenge . Specialties : Organisms C. elegans , B. Thurengensis , E. coli , Bacteriophage M13 Protein Biophysics Folding , Particle analysis , aggregation amyloid , Lab Automation HTS , Lab on chip , Molecular Biology PCR , qPCR , RT PCR , cloning , Phage Display , Spectroscopy Fluorescence , Circular Dichroism , FT IR , NMR , Electrochemical Impedance , Pulsed Voltammetry , Microscopy LSM , FRET , ImageJ , MFI Programming : Python , Javascript , C .net , MongoDb , Borland Delphi , VB.net , Java , Microsoft Excel VBA , Assembly language 6502 and 680x0 .. Technologies : SLS DLS;CD;NMR;FRET",peptides;proteins;characterization;formulation;screening;stability
"Senior Manufacturing Manager . . I am experienced in biochemical and molecular cell biological methods used in research and development of bio pharmaceuticals and diagnostics . For example construct design and protein expression USP , protein purification of soluble and membrane proteins DSP , biochemical analysis , ITC , structural biology , immunohistochemistry and confocal microscopy . Furthermore , I have organised international meetings , presented at conferences , lectured medical students and negotiated pricing for laboratory equipment . The methods I have used in particular include : Molecular genetics restriction cloning , PCR , DNA purification , Sequence analysis after Sanger sequencing etc . Bacterial and human cell culture Protein over expression Automated protein purification SEC , IMAC and IEX together with KTA FPLC of soluble and membrane proteins SDS PAGE , Western Blot , BN PAGE Preparation and use of various in vitro translation and transcription extracts siRNA knockdown experiments CRISPR Cas Confocal fluorescence microscopy Preparation of liposomes , proteoliposomes and inverted inner membrane vesicles from E.coli ITC some MST Site directed cross linking Protein modifications via maleimide coupling Other experience : Negotiated pricing and organised instrument demonstrations Managed ordered laboratory consumables and maintained equipment Contributed to setting up a new lab Co ordinated practical courses ELISA technique for up to 30 as team leader and lecturer Supervised several students and their degree projects Organised the SGBM retreat 2013 and EBEC2012 Student speaker of the IRTG 1478 2011 12 Contributed to research conferences meetings Collaborated with other research groups Presented my work to peers Contributed to scientific articles in peer reviewed journals . Technologies : ITC;MST",biologics;membrane proteins;developing;interaction
doctoral fellow . . . Technologies :,
"Scientist II . At Apeel Sciences , we work with nature to improve access to quality , reduce waste , and ensure an abundant future for the planet . It s an exciting moment for the company , and we 're always looking for people interested in building with us Check out our open opportunities : https : apeelsciences.com careers . Experienced Research Scientist with a demonstrated history of successful frontier research in the biotechnology industry . Skilled in Bioinformatics , DNA Sequencing , Statistical Data Analysis , Microbiology , Molecular Biology , Linux , and R. Strong research professional with a Master of Science M.Sc . focused in Plant and Microbial Biology from the University of Illinois .. Technologies :",
"Senior Scientist , Process Research . . Synthetic organic chemist with experience in pharmaceutical industry in fields of small molecule drug discovery , medicinal chemistry , synthetic planning and methodology development , multi step synthesis . Proficient in writing scientific publications .. Technologies :",small molecules
"Senior Scientist . . I am a passionate and committed medicinal organic chemist and have a strong track record over 6 year research experience in drug discovery field . I love bioactive small molecule design and synthesis for ADME profiling optimization and in vitro vivo efficacy in order to develop a good drug candidate . I have a strong background in structure based drug design and target oriented synthesis . Multi steps synthesis over a broad range of reaction types , conditions and scales mg to 100 gram . Synthesis , purification , and characterization of chiral compounds . Knowledgeable in drug discovery process from hit to lead candidates Mastering chemical analysis and structural characterization by LC MS , HPLC , and NMR instruments . Extensive experience in use of drug discovery tools to resolve troubleshooting in projects . Excel in multidisciplinary environments , collaborating with computational chemist , biologists , and DMPK scientists . Specialty includes : Medicinal chemistry , synthetic chemistry , structure based drug discovery , chemical library synthesis , and heterocyclic chemistry . I am currently looking for new challenge in drug discovery . Personal contact : chemwglee gmail.com . Technologies : NMR",small molecules;characterization;developing
"Head of R D . Managing and leading R D department with biologists , software developers , physicists , and electronics mechanical engineers Responsible for development of image based systems for automated cell analysis Innovation strategy and establishment of external relations Development of assays and computer scripts for numerical cell analysis . Molecular geneticist and R D manager with 20 years experience from academia and industry . Expertise in genetics , molecular biology , cell biology , protein expression and cytometry Ample experience with development of protein therapeutics and industrial enzymes Long track record of developing in vitro assays and cell based assays Strong skills in integrated and automated solutions Knowledge of transferring research projects from the bench into the marketplace Extensive experience with project management , team leadership , innovation strategy and attraction of external research funding Author of 25 publications several of them in high impact journals and patent applications Specialities Classical and molecular genetics Genetic engineering Micro arraying Development of in vitro and in vivo screening and selection systems Screening and selection of enzymes and protein variants Directed evolution High Throughput Screening Strain improvement Recombinant protein expression production Nucleic acid and protein purification and characterization Enzyme kinetics Antibody development and characterization Immunochemistry and fluorescence Fluorescent in situ hybridization Image and flow cytometry Image and data analysis Instrument development Software script development Higher education teaching and didactic learning R D project management Innovation strategy Establishment and coordination of external relations Attraction of external research funding . Technologies :",antibodies;proteins;engineering;expression;screening
"Head of laboratory Chemical Biology . . Expert in targeted protein degradation PROTACs , MGs for drug discovery . . Technologies : NMR",molecular glues;developing
Cryo EM lab manager . . . Technologies : CryoEM,
Research Associate . . . Technologies :,
"SciLifeLab Fellow MIMS group leader . Responsible for the operative management of a structural biology cryo EM and infection biology research team of 8 members . Supervising and educating team members in performing technical or analytical research tasks , operating complex research equipment , establishing risk management plans , and providing support from initial experimental design to final scientific publication . Responsible for funding acquisition , documentation ELN , scientific publishing and outreach . . Scientist with leadership 3y , research 12y , and IT industry 5y experience in international settings . Skilled in project and team management , scientific writing , molecular and structural biology , biochemistry , and biophysics . Enthusiastic about using high performance computing and cutting edge scientific equipment for structural biology purposes . Avid outdoor adventure and sports enthusiast .. Technologies : CryoEM",proteins;structure
"Scientific Director , Head of Technical Integrator . Leading a fantastic team of Drug Product Technical Integrators . Team composed of scientific and technical experts responsible for integrating all DPD aspects of the vaccine product development and manufacturing from preclinical , early stage , late stage and transfer to commercial . . Industry pharmacist with extensive experience in the development of stable therapeutic and prophylactic peptide protein antibody and large variety of vaccine formulations in both pre clinical , early as well as late stage clinical phases . Specialized in the physical and chemical characterization of biologics and viral vectors using both standard and novel methodologies and techniques . Pioneered the field of high throughput screening of formulations and developed novel spectroscopic and microscopic methods . Worked on over 30 challenging projects as key member of a CRO ; several formulations are currently in phase 3 clinical studies . Experienced in CMC , manufacturing , fill finish and process development and leading transformational team s of sr scientists in complex matrix environment . Other responsibilities include : project management , IND IMPD and MAA regulatory filings , business development , acquisition of new projects , consulting , troubleshooting , due diligence . Specialties : Characterization , formulation , process development , adjuvants , adenovirus , poliovirus , MVA vector , viral bacterial vaccines , delivery systems , gene therapy , DNA RNA delivery , liposomes , LNPs , fill finish , GMP , manufacturing sciences and technology , scale up , tech transfer , freeze drying , high throughput screening , spectroscopy , peptides , protein and mAbs and mono multivalent vaccines . . . Technologies : SLS DLS;CD;FP",biologics;characterization;developing;formulation
"Bioinformatician . Tool development and analysis enabling personalized cancer vaccines . Bioinformatician developing tools to enable personalized cancer vaccines . During my PhD , I developed computational methods to study the effects of diet and genetics on mouse behavior and gene expression . Training pre PhD includes MEng BS degrees in computer science along with 5 years of professional software development experience . I want to apply both my technical and leadership skills to drug development . . Technologies :",
Senior Researcher . Mechanistic physiologically based pharmacokinetic modeling and simulation for model informed drug discovery . . Experienced researcher with a demonstrated history of working in research and development of mechanistic modeling of dynamical systems . Skilled in developing mathematical models and simulation algorithms for computational biology and biotechnology . Research professional with a Doctor of Philosophy Ph.D. in Computer Science from Universit degli Studi di Trento . . Technologies :,
"Prof. . Biology . Research Undergraduate Education Postgraduate Education Specialties : Plant respiration Quantification of RNA realtime PCR , protein and coenzymes Transgenic plants Analyses of organell and membrane protein function . Technologies :",
"Senior Bioinformatics Scientist . . Senior bioinformatics scientist with extensive experience in cancer genomics , both in industrial and academic settings . GitHub : https : github.com martimij My specific experience includes clinical cancer data analysis for the 100,000 Genomes Project , association analysis of rare variants involved in metastatic prostate cancer predisposition , and mutagenesis mechanisms driving haematopoietic cancers . I have extensive experience in whole genome and exome sequencing , variant calling pipeline development for small and structural variants , evaluation of clinically relevant variants , analysis of FFPE and various experimental tumour samples , complemented by my original background and PhD in experimental molecular biology . As a co founder and previous long term board member of the educational non profit organisation Society for Out of Frame Education , I have also gained valuable management and leadership experience .. Technologies :",
"Senior Research Development Scientist . Senior Scientist Drug Discovery Cellular Assay Development , screening and Mode of Action studies for small molecules therapeutic oligonucleotides and PROTACs in High Throughput Screening to Lead Optimization . Expertise in HT Flow Cytometry , FACS , Imaging , qPCR as well as HTRF , reporter gene , radioligand and label free assays with primary , iPS and recombinant cells . Mentoring junior scientists . Engaged and technically oriented scientist within drug discovery with an excellent problem solving attitude . I m a strong team player who can also work independently and enjoy working in cross functional teams and in multiple research projects simultaneously .. Technologies :",molecular glues;nucleic acids;small molecules;developing;screening
"Software Engineer Bioinformatician . Integrate protein 3D structure data and Proteomics data into UniProt protein database uniprot.org . Develop and maintain pipelines to build UniProt backend API services using Solr , Voldemort and Java etc . Setup DevOps pipeline to deploy UniProt services to VMs or Cloud . . Experienced Software Engineer and Bioinformatician with a demonstrated history of building complex pipelines to process big data in Biology . Skilled in Linux , Java , Perl , Python , SQL , LSF , GitLab , Docker , Kubernetes , Cloud etc .. Technologies :",
"Associate Director , Data Science . . Data Scientist in the Life Sciences . Technologies :",
"PhD Researcher Receptor Signaling and Biochemistry Group Martine Smit . ONCORNET network , Marie Sklodowska Curie Funding . GPCR CXCR4 and ACKR3 receptors involvements in cancer . Project management , from formalization to publication . Day to day team management . Two technicians and students , dedicated to my project . Successful European wide collaborations with labs and companies . Speaker and poster presentation in front of large audiences 300 attendees , monthly presentation in lab meetings . Determining phosphorylation profiles of the receptors upon stimulation . Determining kinases involved in the phosphorylation of those receptors . Nanobodies generation against phospho peptides in collaboration with Argenx , Gent . Compound screening . Kinetic characterization of molecules . Cell culture human cancer cell lines . BRET , HTRF , luminescence , radioactive binding , ELISA , FACS , immunofluorescence , western blot , impedance xCELLigence assays . HTRF fluorescence microscopy . Achievements : I successfully led a project on a challenging receptor ACKR3 from start to finish , resulting in a publication with novel data in a renowned journal Cells . I trained students to become fully autonomous . I co created a monthly journal club and presented numerous times in front of large audiences at conferences . . I joined the pharmaceutical industry in Basel early on in my career and successfully grew within this competitive field by working at Actelion , the biggest European biotech now property of Johnson and Johnson . Currently a Marie Curie PhD researcher in Amsterdam , in the field of GPCR signaling pharmacology , I am responsible of my own project in which I manage two technicians , and work in collaboration with other PhD students across Europe . Originally from France , I graduated with a Master 's Degree in Biotechnologies . I gained thorough multicultural experience , working in France , Switzerland and The Netherlands . After gaining practical knowledge of drug development in the industry and project management skills as well as theoretical knowledge during my PhD , I am now looking to transfer my portfolio of skills to a position within the pharmaceutical industry . . Technologies :",antibodies;membrane proteins;small molecules;interaction;screening
"Scientist . leadXpro is a lead discovery company focusing on membrane protein drug targets . We are committed to the application of biophysical and structure based methods for the discovery and optimization of next generation lead compounds . leadXpro s technology platform enables structural determination of membrane proteins where classical crystallographic techniques fail , unlocking structure based drug discovery for challenging targets . We capitalize on the knowledge regarding membrane protein structural biology and facilities of the Paul Scherrer Institute PSI with premium access to the synchrotron Swiss Light Source SLS and the Free Electron Laser SwissFEL . Core expertise beyond X ray include single particle cryo electron microscopy cryo EM . https : leadxpro . ch . . Technologies : Xray;CryoEM",membrane proteins;small molecules;interaction;structure
"Senior Scientific Associate . . An open minded Scientist PhD drug discovery oriented , with strong hands on expertise in cell culture and HTS compatible cell based assays with excellent organization skills . Experienced in the biotech industry and used to work in multicultural and interdisciplinary teams . Topics of studies : Assay Development Drug Discovery In vitro and in vivo Pharmacology . Cell based assays : 384 well format , second messenger release signaling pathways , cytotoxic and proliferation assays , cell transfection , lentiviral transduction , SiRNA . Cell culture : primary cells , recombinant mammalian cells , tissue slices , microexplants . Immunology : ELISA , Meso Scale Discovery , cellular functional assays , cytokine quantification , . immunophenotyping by flow cytometry . Molecular biology : RNA extraction , qRT PCR and PCR . Histology : immunofluorescence and image analysis by confocal microscopy . Small molecules screening using phenotypic screen . Animal handling : IP , IV , gavage , IT , necropsy , blood and tissue sampling . Technologies :",
Laborleiter . NMR Spektroskopie zur Strukturaufkl rung . Lab Team Leader for NMR Spectroscopy at BASF . PostDoc with Lucio Frydman at Weizmann Institute of Science . PhD with Harald Schwalbe at Goethe University . Passionate about Biophysical Chemistry and Magnetic Resonance Spectroscopy .. Technologies : NMR,proteins;structure
"Machine Learning Scientist . . Molecular biologist turned data scientist . Passionate about applications of AI in medicine and health tech such as patient monitoring , disease prediction , EHR analysis , medical imaging , and telemedicine . Prior work experience in clinical trials for 3.5 years . Postgraduate research on cancer screening tools using deep learning and computer vision . Currently working as a data scientist for project Fizzyo at UCL , aimed at improving care for children with Cystic Fibrosis . . Technologies :",
Associate Scientist . . . Technologies :,
"Specialist . Experienced researcher in the field of In vitro pharmacology , with a main specialization in flowcytometry and Antibody Drug Conjugates . In 2011 I started working for Byondis . I first started as a technician for 1 . 5 year at Bio analytics within CMC and since August 2013 made the switch to the Research department where I 'm currently still working as a Specialist within the In vitro pharmacology group . Over the years I 've acquired extensive knowledge in the field of flowcytometry , both as a researcher on the practical aspects and as an operator being responsible for inhouse training of co workers and equipment maintenance . Within Byondis , I developed a broad knowledge on Antibody Drug Conjugates in general and all the different in vitro experiments that contribute to the preclinical development . Furthermore I also take a lot of interest in Immuno oncology to which my flowcytometric skills come in handy for the development of various assays . . Technologies :",antibodies;characterization;stability
"Process Development Scientist . 1 . Development and analytical characterization of monoclonal antibody formulations 2 . Design and execution of stability , stress , compatibility , risk assessment studies supporting formulation selection and shelf life stability 3 . Author and review CMC sections of regulatory submissions 4 . Techniques : Nephlometer , viscometer , Density meter , Osmometer , HIAC , MFI , Solo UV , MCE SDS , DSC , SE UPLC , Ion exchange UPLC . Highly motivated researcher with demonstrated background in Pharmaceutical and analytical development and Chemical biology , . PhD of Chemical Biology from USC . Publication record of 16 peer reviewed journal articles , book chapter , and abstracts in national and international conferences . Hands on experiences in most of formulation , analytical , and biological experiences . Ability to work independently , data analysis , problem solving along with analytical and creative thinking skills . Motivated and flexible to learn new techniques .. Technologies : DSC",antibodies;formulation;stability
Computational Biologist . . . Technologies :,
Scientist . Mode of Action studies on therapeutic antibodies qPCR technology platform leader . Enthusiastic and passionate molecular and cell biologist with extensive experience in cell based in vitro assays and a PhD. degree in molecular mechanisms of disease .. Technologies :,antibodies;characterization
"Research Fellow . Discovered peptide substrates that are specific to Dipeptidyl Peptidase 9 DPP9 , a key protein responsible for mediating inflammatory cell death through pyroptosis . Developed assays to detect enzymatic cleavage of small peptide fragments by specific enzymes as well as whole cell lysates . Developed aminopeptidase inhibitors that contribute to pyroptosis of cells by the build up of small peptide fragments . Synthesized a library of small molecules that , along with the small molecule DPP9 inhibitor Talabostat , showed synergistic pyroptotic cell death . Synthesis of biotinylated and fluorophosphate chemical probes for studying the process of pyroptosis . Synthesis of PROTACS Proteolysis inducing Chimeras targeting the degradation of caspases . . Gained cell culture experience with different cell lines , harvesting cell lines for lysates , western blotting techniques . . Performed high throughput screening with 384 well pintool instrument . . Obtained analytical mass spectrometry experience using a high throughput Rapid fire mass spectrometer . Synthetic Organic Chemist with over 10 years of research experience in multi step natural product synthesis , medicinal chemistry , small molecule library development , method development , compound characterization , SAR optimization . Diversified skills in chemical biology including enzymatic assays , chemical probes , cell culture work as well as adept at keeping neat record of data and presenting them to team members . Demonstrated ability to resolve key scientific hurdles with critical thinking and expertise and execute assignments in a timely fashion . Team player with excellent collaborative skills between inter disciplinary teams as well as proven mentorship skills in undergraduate and graduate research .. Technologies :",molecular glues;peptides;proteins;small molecules;screening
"Principal Scientist . . Passionate about translating cutting edge biomedical discoveries into novel treatments or therapeutics . Highly interested in gene therapy and viral vectors . As a research scientist , have more than 10 years hand on experience in Human Immunodeficiency Virus HIV , Viral Immunology , Antibodies , Adenoviral AdV vectors and Adeno associated viral AAV vectors , leading to 20 peer reviewed publications , 680 citations and 2 issued patents . Working on improving AAV vectors yields by screening new helper genes and engineering helper plasmids . Identified a novel helper gene that can improve the yields of AAV2 and some other serotypes by 100 . Led a project to develop gene therapy of HIV infection by using helper dependent Adenovirus vector HDAd carrying broadly neutralizing anti HIV antibodies bnAb in mouse models . Constructed multiple bi specific bnAbs with great potency . Optimized HDAd vectors carrying Luciferase or bnAbs , leading to over four months active gene expression in mouse model with a single intramuscular injection . Enjoy the pleasure of talking , working with people and making new friends . Volunteered in many non profit organizations , such as North America Maple Culture Center , Chinese Association for Science and Technology in Connecticut CAST CT , Career Network for student Scientists and Postdocs at Yale CNSPY . Served as reviewer for many scientific journals including Viruses , AIDS Research and Human Retroviruses , Archives of Virology and Cells etc . Enjoy life . Like modern drama , Tango , swimming , reading and poetry . Skills : Molecular cloning , Viral vectors lentiviral , retroviral and adenoviral vector , Antibody engineering , Small RNAs , Collaboration building BMS ViiV Healthcare , Team management , Communication .. Technologies :",antibodies;biologics;carriers;engineering;screening
"Sr Director of Bioinformatics . . Experienced bioinformatics scientist with a demonstrated history of driving projects from inception to product and employing disparate data to provide actionable insights and technological direction . Skilled in research and development , biotechnology , data engineering , and software engineering .. Technologies :",
Associate Research Fellow . Cryo EM . Image processing . Data Analysis . . .. Technologies : CryoEM,
"Head of Computational Immunology , Priovant Therapeutics . . . Technologies :",
Associate Director Computational Biology . . . Technologies :,
"Associate Scientific Director . Quantitative clinical pharmacology , M S , and drug development in oncology assets QCP lead for multiple programs spanning Ph 1 4 , including small molecule , oncolytic virus , and conditional bispecific T cell engager modalities . Current role in Clinical Pharmacology ; experience in gene therapy and small molecule drug development Expertise in mathematical modeling of biological networks , PK PD and mechanistic approaches , systems biology , and stochastic systems . Technologies :",
"Senior Scientist Biochemistry and Assay Development . Team leader of a biochem lab with 4 technical assistants and a doctorate student Research topics : Enzyme development , Enzyme kinetics , Protein engineering Directed Evolution rational design , HTS assay development , Protein Purification kta , bioanalytics , project managment . Experienced Senior Scientist Group Leader with a demonstrated history of working in the research industry . Skilled in Protein Biochemistry , Enzyme Assays , High Performance Liquid Chromatography HPLC , Enzyme Kinetics , and Protein Engineering . Strong research professional with a Doctor of Philosophy Ph.D. focused in Biochemistry from Freie Universit t Berlin .. Technologies :",enzymes;characterization;engineering
"Analytical Specialist . . CORE COMPETENCIES : LC MS Small molecules , structure elucidation and quantification . Orbitrap , qTOF , triple quad and single quad HPLC Peptides Skyline , Compound discoverer , Biopharma finder . Massfontier , chemstation , masshunter Assay development and screening . Protein purification and characterization . Protein engineering by directed evolution primarily enzymes for baking Development , optimization and validation of Drug Substance processes . Support and troubleshooting to existing Drug substance processes . Preparation and review of registration documentation . Development , optimization and validation of Source Material processes Immuno chemical analysis . Project management Personal characteristic . Innovative , analytic , systematic , result orientated , Flexible and a team player . Technologies :",proteins;small molecules;characterization;structure
"PhD Student . . M.Sc . in Biochemistry . Structural biologist with interests in disease related receptor interactions , structure based drug design and rational protein design . Researcher of Polyomaviruses and their host tropism . Protein expression in E. coli and cell culture . Chromatography and protein crystallography . Big fan of x ray diffraction , data analysis , and protein structure modeling . Currently setting foot into cryo EM .. Technologies : Xray;CryoEM",proteins;small molecules;interaction;structure
"Principal Biologist . . Molecular biologist with experience in cell signaling , cancer and structural biology research . As part of Amphista Therapeutics , I focus on exploring the targeted protein degradation approach for the benefit of people suffering from numerous diseases . . Technologies :",molecular glues;interaction;structure
Scientist Cryo EM . . . Technologies : CryoEM,structure
"Research Technician . protein expression and purification cloning structural studies of protein nucleic acid complexes with cryo EM training undergrad students welcoming new team members organizing the lab , keeping track of orders , stocks . . Technologies : CryoEM",nucleic acids;proteins;expression;structure
"Machine Learning Scientist , Perturbational Biology . . . Technologies :",
"Lecturer . . I am a charismatic and engaging educator and also , a talented and highly motivated scientist with a solid understanding and knowledge of pharmacology . I have spent about two decades in pharmacy , pharmaceutical , pharmacology , medical science , Ph.D. , MPharmSc , BpharmSc , and industry experience drug discovery , compound profiling , small molecule , cell based fluorescence assay , high throughput screening , multi well plates and electrophysiology . I have more than 10 years ' research experience in early stage drug discovery , safety pharmacology , drug target identification , ion channel as drug targets in cardiovascular , diabetes , and cancer , in vitro , in vivo , and human tissue pharmacology . I have been employed as a cultural liaison with the Center for Learning and Teaching , Dalhousie University , Canada . In addition , I have very strong therapeutic expertise within cardiovascular and diabetes , both clinical and research . Also , I have developed excellent customer facing skills in pharmacy . Importantly , I had the privilege to work on a drug discovery project for almost three years with a world class environment , Max Planck Institute . I have a wide range of teaching experiences three certificates in teaching in higher education as a lecturer , tutor , instructor and lab supervisor , and most importantly , incredible student feedback . Experience and skills : Health Care Coach , Communications and Presentations at International Level , OTC Sales Manager , Drug Discovery Research , Solid Knowledge of Therapeutic Pharmacology , Pharmaceutical Sciences , Clinical Trials , Writing , Publications , Expert in Drug Target Membrane Protein , Ion Channels , Calcium Signalling , Compound Profiling , Project Manager and Leadership , and Electrophysiology . I offer exceptional organizational and communicational skills , disciplined work ethics , and a team oriented mentality applicable to multiple therapeutic areas . Publications List : https : scholar.google.co.uk citations user IM3GEtoAAAAJ hl en . Technologies :",membrane proteins;small molecules;screening
Director of Biostatistics . . . Technologies :,
"Clinical Lab Operations Improvements Lead . . Currently hiring in multiple roles Bfx , fluorescence microscopy , Mol Bio assay dev , automation , consumable manufacturing for my team . Reach out to work with a great group on cell free DNA based diagnostic screening I have spent the last 15 years combining biology , physics and computer science in research , commercial , and diagnostic settings , as well as personal projects . I 'm most excited about using these skills in a biomedical setting where I can have a direct , positive impact on human health . I am particularly interested in genomics and helping to deliver on the promise of personalized medicine . Specialties : Bioinformatics , Genomics , Electron Microscopy , C , Algorithm development , Teaching , Molecular Biology . Technologies :",
Bioinformatics Team Leader . . . Technologies :,
"Senior Scientist . Senior Scientist High Content Screening . Project leader for High Throughput Screenings . . Specialist for High Content Screening Automated Imaging HCS ; Development of Biochemical and Cell based Assays for Pharmacological Screenings HTS ; Strong expertise in Cell Culture , Molecular Biology , Cytometry FACS Analysis ; Multi year experience in Electrophysiological Characterization of Membrane Proteins , Protein Chemistry , Product Specialist for Scanning Electrochemical Microscopes SECM , Microelectrodes and Accessories ; Experience on the fields of Sales , Project Funding and Organization , Customer Support . Keywords : Creativity , Interdisciplinarity , distinct Ability to work in a Team , very good Communication Skills , Mobility , Sociableness . Technologies :",membrane proteins;screening
"MS T Downstream Purification scientist . . I have gained a lot of experience and skills in a wide variety of fields throughout my Ph . D. These skills include ; . Expression and purification of proteins from host cells . DNA manipulation of proteins to create better functional protein molecules . Lectin probe validation . Mammalian cell culture . In vitro cell probing using a wide variety of lectin and antibody probes . Flow cytometry . Fluorescent Microscopy . Throughout my 4 years of research , I have gained a wide variety of experience and knowledge around the glycobiology and cancer fields . . I have presented my work a number of times and won the best 5 minute presentation at the annual DCU school of biotechnology research day in 2017 . . Technologies :",biologics;engineering;expression
"Postdoctoral Researcher . Profound expertise in . Engineering of novel bispecific T cell engaging antibody constructs Hemibodies . Bacterial expression of antibody constructs in shaking flask and 10 L fermentor Sartorius BiostatC . Antibody expression using suspension CHO cells in shaking flask and mini bioreactor system Eppendorf DASbox . Chromatographic purification of antibody constructs kta system . Design and implementation of T cell killing assays . Antibody screening Nanobodies , scFvs and DARPins . Knob into Hole antibody format design . Transposon mediated gene transfer PiggyBac system . Supervision Mentoring of Bachelor , Master , MD and PhD students . Public relations work crowdfunding for cancer research . Patent writing . . Technologies :",antibodies;engineering;expression;screening
"Senior Scientist . . I am investigating the application of targeted therapy using antibodies for targeting and drugs cells for treatment . I am in particular interested in antibody fragments from heavy chain only antibodies , indicated as VHHs or nanobodies . Technologies :",antibodies;interaction
Computational Biologist . . . Technologies :,
Bioinformatics Analyst . . . Technologies :,
"Sr . Director , Bioinformatics . . In the recent years I have been a bioinformatics scientist , software developer , and consultant . I have a strong background in both Computer Science and Biology and have had extensive experience working with professionals and academicians from both fields . I have done research , analysis , and developed software in both Windows and Unix environments using languages such as Perl , Python , R , Matlab and C . Specialties : bioinformatics , next generation data , software engineering , perl , matlab , microsoft c , research , software development and testing , statistics , data analysis and processing , project management . Technologies :",
"Ph . D Student . . 5th year PhD candidate in chemistry at Case Western Reserve University . I will be defending my dissertation in the spring of 2023 . I am studying RNA protein interactions using comprehensive biophysical methods including NMR , ITC , cryo EM and DMS MaP seq . I am currently working on the human coronavirus OC43 . . Technologies : CryoEM;ITC;NMR",nucleic acids;proteins;interaction;structure
"Scientist I . Lab automation screening . R D scientist with 11 years experience in academia and industry . Proficient in molecular biology and mammalian cell biology , most recently specialized in methods for targeted protein degradation and mRNA delivery . Fully capable of conducting research work strategically and independently , driven by creativity and strong problem solving competences . Passionate about building innovative technologies to bring medicines to patients .. Technologies :",molecular glues;interaction;screening
"Science Specialist . . As an undergraduate student at Stuttgart University , I fell in love with electron microscopy . Starting as a PhD student at EMBL Heidelberg in the team of Dr. Yannick Schwab I got fascinated with the combination of light and electron microscopy and its potential , especially looking at 3D rather than just 2D. Correlative light and electron microscopy CLEM experiments uniquely provide an accurate link between the imaging of individual living cells and their 3D ultrastructure . However , they generally suffer from a low throughput . The major hurdles include tracking the object throughout the different imaging modalities , the tedious procedures for sample preparation and the lack of automation in the data acquisition by electron microscopy . Therefore we developed a workflow to select a subpopulation of cells in light microscopy and a software to target tens of them in an automatic manner in the focused ion beam scanning electron microscope FIB SEM for volume acquisition . Fluorescence microscopy is utilized to screen for specific phenotypes and electron microscopy to look at the corresponding ultrastructure . By combining CLEM and automated serial imaging , we intend to dramatically improve the throughput of CLEM experiments . During my time at EMBL , I was lucky to be able to collaborate with different groups inside and outside Germany for different correlative light and electron microscopy projects looking for example at the nuclear envelope assembly at the end of mitosis Ellenberg lab , EMBL or how to combine on chip light microscopy with volume EM imaging of liver cells Ahluwalia lab , The arctic university of Norway . I quickly realised that I am extremely interested and passionate about various projects , using and developing new techniques to answer different biological questions . Therefore I wanted to continue working in a multi user environment . I consider myself lucky to now currently work as a post doc in the Electron Microscopy Core Unit at the Max Planck Institute of Experimental Medicine in G ttingen . Besides working on high resolution volume EM imaging of myelin mutants and the implications for axo glial interactions , I could also gain more experience in the very fascinating field of Cryo FIB SEM volume imaging and lamella preparation . Continuing in method development and different cryo electron microscopy methods I have joined the EM team of the new Imaging Center at Embl .. Technologies : CryoEM",structure
"Computational Biologist Bioinformatician Postdoctoral Research Associate . I am located at the Cambridge Centre for Proteomics http : proteomics.bio.cam.ac.uk in Kathryn Lilley 's group at the University of Cambridge . My main research area involves the design and development of software and computational pipelines for the analysis and visualisation of high throughput mass spectrometry MS based proteomics data . My work ranges from the processing of low level raw proteomics data , through to protein aggregation , differential abundance analysis and the generation of sub cellular proteome maps for species ranging from single cell organisms to complex mammalian cell lines . Core elements of my research include the development of novel machine learning methods for 1 differential protein localisation following treatment , for example drugs and stimulus , 2 novelty detection methods for the identification of unannotated sub cellular complexes , and 3 for the integration of heterogenous data , for example transcriptomics data , imaging data etc . In terms of biological applications , these methods have been used to infer sub cellular spatiotemporal changes in the proteome for different species and cell lines I am an R and Bioconductor package developer and contributor for a number of computational proteomics packages . I am also principally involved in the implementation and maintenance of a suite of interactive visualisation tools using R Shiny for the dissemination of spatial maps for both in house use and for the cell biology and proteomics communities . . Computational Biologist located at the Cambridge Centre for Proteomics CCP , University of Cambridge . My main area of research focuses on computational analysis of high throughput quantitative spatial proteomics data and development of new machine learning tools and R packages .. Technologies :",
"Head of Service , Clinical Computational Research Informatics . . Specialties : Python , Perl , SQL , PL SQL , JavaScript , Bash , OpenStack Cloud . Technologies :",
"Staff Scientist , Bioinformatics . Gene expression and methylation R D . : : More than six years of experience in Python programming , R programming , Bash Scripting , and Next Flow pipeline . Capable of making reproducible codes and easy to use Python and R packages . Routinely use NumPy , Pandas , Scikit learn , Scipy , and many other packages for data code development and data analysis . Also , have working knowledge in Perl , HTML , CSS , and Javascript . : I have been analyzing NGS datasets from TCGA , ICGC and many other sources to define somatic mutational signatures using single nucleotide variants SNV , copy number variants SNV and structural variants SV . We use the mutational signatures to associate cancer risk factors with different types of cancer and assessment of targeted therapeutic approaches . I also have the experience to use different genome analysis frameworks such as GATK and Dragon Bio IT platforms as well genome analysis tools BWA , Samtools , FastQC and variant callers Mutect2 , Strelka2 , VarScan , MuSE . : Developed tools that are capable of doing parallel computing using multiprocessors and multithreading . Also , implement a message passing interface MPI in python to use CPUs from separate nodes in a parallel fashion . Routinely implement GPU enabled coding using PyTorch and TensorFlow frameworks . : Have excellent command and understanding of both supervised and unsupervised machine learning algorithms . Hands on experience with SVM support vector machine , Logistic regression , Random Forest , deep learning algorithm , Non Negative Matrix Factorization , PCA , Kmean , and Hierarchical Clustering . Also , have good knowledge of algorithms for DNA Sequencing . : Comprehensive experience in using Amazon Web Service AWS . Perform large matrix operation based data analysis in both CPU , GPU , and memory optimized instances . Quite familiar with storing , send , and receive data in S3 buckets . Also , routinely use other cluster supercomputers at UC San Diego . : Have comprehensive and in depth knowledge of machine learning , next generation sequencing NGS , molecular biology , immunology , cancer genomics , and cell signaling pathways . . Technologies :",
"PHD Candidate in Protein science Structural biology . Structural and functional properties of copper transporters . In general , details always grab a lot of my attention and when it comes to science , I have a huge interest to figure how exactly proteins are and function . I am extremely fascinated by the methods allowing us study the function of proteins and I feel lucky for being able to do so since 2015 . In this context , I have become experienced with both worlds of soluble and membrane proteins produced in small or large scales in yeast and bacterial systems . I am skillful in up downstream processes of protein characterization ranging from production of mutants to purification and functional studies .. Technologies :",membrane proteins;characterization;interaction;structure
"Research Laboratory Manager Dept . of Cardiovascular Medicine . Designing and conducting murine inhalation toxicity testing using tobacco and e cigarette products . Evaluating the toxic effects of tobacco and e cigarette products in the cardiovascular system , specifically in transgenic mice . Areas of technical expertise : rodent mouse colony management , animal husbandry , molecular biology , histology , immunostaining , microscopy , and image data analysis . Lab administrative responsibilities : Lab inventory organization and maintenance , Lab safety coordinator , Lab protocols development and maintenance , Lab supplies ordering , Lab equipment maintenance troubleshooting , Coordinating with facilities vendors for general technical lab support . Proficient in GLP safety regulations Molecular and Cell biology experience : DNA RNA isolation from tissues and cells , PCR , RT PCR , qPCR , vector design , gene cloning , and expression , ELISA , MTT assay , RNAScope , nanoString Microbiology experience : Proficient in establishing bacterial cell cultures both aerobic and anaerobic ; Time kill assays with antibiotics ; Minimum Inhibitory Concentration MIC determinations Molecular Virology experience : Isolation and growing bacteriophages from clinical samples and the environment Histology experience : Processing samples FFPE , Cryosections Immunology experience : Immunostaining Immunofluorescence IF and Immunohistochemistry IHC Microscopy experience : Brightfield , Fluorescent , Scanning Electron Microscope SEM Small animal handling mice injections : Intraperitoneal , Tail vein , Oral gavage ; Mice colony management Laboratory management inventory maintenance ; instrumental troubleshooting ; Lab safety coordinator Preparation of media , buffers , and reagents Experience in bacteria infections related research and studies Skilled with computer application packages : Microsoft Office and Mac ; Statistical tools : GraphPad Prism ; Image analysis tools : Fiji ImageJ , Cell profiler , QuPAth , Aperio ImageScope ; R programming Excellent oral and written communication skills SOP , documentation Adept at planning and meeting deadlines . Technologies :",
"Postdoctoral Researcher . Dong group project management . Scientific research activities : Cryo Electron Microscopy . Transmission Electron Microscopy . Mammalian cell lines cultivation . Advance microscopy technics FRET , FRAP , FLIM . Molecular biology methods . Basic and advanced biochemical methodologies . Advanced spectroscopy methods CD , LiSSP , DSF , nanoDSF . Flow cytometry . 3D modelling Chimera , PyMol . Statistical analysis . Mass spectroscopy . Prokaryotic and eukaryotic protein expression systems . Classic and chromatographic protein purification . Bachelor , Master and PhD students ' tutoring . . Postdoctoral scientist with expertise in virology , antiviral development , biochemistry , structural biology , and immunology . Strong project and team manager with a proven ability to meet tight schedules and flexibility to work under pressure with tight deadlines and late hours . Excellent communication and teaching skills with an emphasis on science dissemination and interdisciplinary collaborations .. Technologies : CryoEM;DSF;FRET",proteins;characterization;structure
"Research Scientist II . 1 . Cancer Genomics Performed pan cancer epidemiological genomics analysis . This work answers a surprisingly unanswered question about epidemiological incidence of cancer associated mutations Nature Comm . 21 , KMCO 22 Collaborated with medical doctors assisting histological and locational annotations of samples from 139 whole exome sequencing studies including 20,000 patients . Processed epidemiological clinical data of cancer cases in the US and implemented automatic annotations combining histological and locational clinical data 7 million patients , 670 cancer types . Created a map based on conditional probabilities to reweight sequencing data by epidemiological distributions . Created error estimation and propagation methods to simulate errors induced by random variations in input data . Other genomic projects : Mitochondrial OXPHOS signaling in RNAseq patient data . 2 . Systems biological modeling Used mathematical models of RAF protein and RAF inhibitor interactions to predict resistance mechanism to next generation drugs . Used theoretical physics tools to completely solve active RAF as a function of parameters such as RAF dimerization constant , RAF drug interaction constant and concentrations of RAF and drug . Created code in Mathematica to validate hand derived expressions and perform analytic sensitivity analyses . Created numerical code in python to simulate more complex models integrating clinical , biophysical and biochemical experimental data . Other protein signaling in silico projects : NOTCH signaling , EGFR signaling , RAS signaling . Created and implemented non convex clustering algorithms to search for related computational mutants representing novel protein interaction strategies among co mutations of NF1 a tumor suppressor and RAS . 3 . Developed methods for and performed biophysical RAF drug interaction measurement using thermal differential scanning fluorimetry TSF DSF . . Computational Biologist with an extensive background in theoretical physics and a desire to use quantitative techniques to study and treat human disease . Experienced in integrating data from several sources such as biophysical assays , sequencing , molecular biology assays and clinical patient data . The evaluation of genomic changes and their impact on protein signaling in normal and diseased conditions so as to inform therapeutic strategies and side effects is of particular interest .. Technologies : DSF",
"Senior Research Scientist Associate Director Lead Investigator Research Associate . Hired as research associate and promoted into role charged with establishing and leading interdisciplinary research center for Harvard Medical School s affiliated teaching hospital . Forge and sustain relationships across the enterprise to further R D objectives and align efforts with institutional goals . Establish and manage vendor relationships for innovative technologies via engagement programs and sponsored research agreements . Charged with recruiting , managing mentoring teams of up to 10 , prioritizing tasks , projects works collaboratively with internal research computing teams . Built research center s robust technical infrastructure from the ground up : evaluate , purchase , install and support 6 functional MRI systems on 6 Siemens or GE 3 T MRI scanner sites ; participate in multiple PET ligand evaluations , studies data analysis ; took accountability for full alignment with institution wide data architecture with streamlined operations ; lead modernization of computing systems enabling diverse research studies to collect and investigate large data sets ; architected first of its kind integrated eye tracking recording solution for functional MRI studies , collaborating with multiple key vendors of hardware software to steer development ; implement plans for health safety compliance , laboratory administration ; manage multiple projects in complex technical facilities for both clinic research studies . Promoted and adopted intuitive best practice approach solutions from NextGen GWAS multi omics data analytics in diagnostic prognostic predictive applications in Oncology and Immunology into the field of functional brain imaging and CWAS Connectome Wide Association Study data analytics in CNS diseases . Directed and nurtured an interdisciplinary STEM team , in coordination with directors of labs divisions , to adopt , improve , and innovate data science solutions that integrate multiple disciplines ahead of the rest of the field . . Thought leader and data science pioneer with significant track record for translating AI ML algorithms and advanced statistics capabilities for real world applications . Recognized as creative , resourceful , integrative expert in extracting and analyzing patterns from high dimensional datasets to shape and deliver predictive and optimized data solutions in translational precision medicine . Collaborative medical imaging director who partners across disciplines and gains executive level buy in for quantitative software tools in advanced in vivo neuroimaging , directs productive collaboration relationships with industry leading vendors , serves as expert in planning , designing , optimizing conducting MRI PET imaging experiments , quantitating interpreting imaging data . Award winning researcher and instructor dedicated to train and motivate the next generation of data scientists and imaging researchers . Convene diverse stakeholders to unlock previously untapped avenues and pave way for cutting edge solutions . SELECT ACHIEVEMENTS AREAS OF EXPERTISE : Spearheaded groundbreaking solution to drive major advancements in developing first of their kind , statistical , data driven diagnostic tools for guiding the treatment of CNS disorders . Established led interdisciplinary neuroimaging research center to enable development delivery of cost effective , successful diagnostics treatments in CNS medicine . Earned Mass General Brigham Excellence in Innovation Award 2X and Pillar Award in Research Innovation , with 60 journal publications . Led imaging data science efforts hands on executions as a core team member on 20 federal institutional projects , with deep understanding of imaging techniques across multiple modalities , demonstrated ability to collaborate with researchers of diverse background , consistently delivered analysis results with significantly higher performance than state of the art packages in the field . Created best practice approaches for optimized data acquisition , biomarker discovery automated informatics reporting and data visualization pipelines based on MRI methodology , resulting in 4 patents . Medical Imaging Statistical Analysis Large Scale Data Analytics Network Neuroscience Computational Biology Strategic Planning Execution Excellent Problem Solving , Collaboration , Communication Writing Skills Software Development Data Visualization Programming Skills C R SQL Python Cloud Computing Cross Functional Projects Program Management Industry Experience Academia Industry Engagement . Technologies :",
"Biochemistry PhD Candidate Kollman Lab . I study the dynamic assembly of enzymes involved in purine biosynthesis through the use of cryo electron microscopy cryoEM and other biophysical techniques . . I will graduate with my PhD in Biochemistry in June 2022 focusing on using protein purification , cryo electron microscopy , and biochemical assays to define allosteric regulation mechanisms . I have performed in vitro characterizations of mutations that lead to human blindness and developed an animal model to study the molecular mechanism of disease . During my PhD I have lead a variety of projects , mentored 7 graduate students , and established lead a new collaboration that has been supported by multiple grants resulted in a publication . My scientific expertise includes : Curious and highly motivated collaborative scientist , supported by a strong publication record with multiple interdisciplinary collaborations Significant experience developing recombinant protein expression purification protocols Extensive use of cryo electron microscopy cryo EM and model building Experienced leader and has trained 7 graduate students 2 undergraduate researchers . Technologies : CryoEM",enzymes;proteins;characterization;expression;structure
"Teacher . . Ultrastructural sudies of rod photoreceptor nuclei from SCA7 mouse . The spinocerebellar ataxia SCA7 is a polyglutamine polyQ expansion disease in which the retina is affected and results in blindness . Ataxin 7 ATXN7 , the protein mutated in SCA7 , is a subunit of the hSAGA complex . The hSAGA coactivator is known to regulate transcription , notably through histone acetylation mediated by the GCN5 histone acetyltransferase . In SCA7 mouse models the overexpression of polyQ expanded ATXN7 in rod photoreceptors induces a progressive retinal phenotype resulting in rods dysfunction with electrophysiological , histological and transcriptional abnormalities leading to a dramatic alteration of the rod nuclear architecture . Specialties : Electron Microscopy of rod photoreceptor nuclei Preparation of retina samples for Electron Microscopy : Retina dissection High Pressure Freezing Freeze substitution Ultramicrotomy Electron Tomography of rod photoreceptor nuclei tilt series acquisition FEI soft reconstruction Expect 3D Immunogold labelling on ultra thin cryo section with the Tokuyasu method Cryo Electron Microscopy of Vitreous Section cemovis . Technologies : CryoEM",
"Senior VP Research . . I am an experienced leader and drug discoverer who has worked in the pharmaceutical industry for over 20 years , following 10 years in academia . As Head of Oncology Drug Discovery for the Novartis Institute for Biomedical Research NIBR , Basel Site , I have overseen significant part of NIBR s global oncology drug discovery portfolio from target discovery to clinical development . While . working in the Oncology Drug Discovery , I have initiated and supported the development of drugs like Glivec , Tasigna , Afinitor , Midostaurin , as well as PI3 K inhibitors and many other signal transduction inhbitors that are in Phase I II III or preclinical development . . In the past 6 years , working in the Expertise Platform Kinases at Novartis Basel which I initiated and implemented , I focused on protein kinases as a target class for various therapeutic indications leading a group of scientists dedicated to integrated lead finding , profiling , project support and project management spanning oncology , immunology , inflammation , muscle , neuroscience , infection and neglected diseases . I have a long standing experience in drug discovery from early hit finding to H2L to lead optimization to introduction to clinical trials . I have worked successfully in various oncology programs in the pharmaceutical industry Ciba and Novartis for over 20 years and have a broad skill set in drug finding as well as managing people . . Technologies :",proteins;small molecules;interaction;screening
"Assoc . Scientist . . Over the four years of working in the industry , I have supported the development of a range of innovative drug modalities such as small molecules , PROTACs , engineered peptides proteins , antibodies , RNA based therapies as well as various drug delivery approaches across many therapy areas . In my recent position in the Immunotoxicology Team at AstraZeneca I have gained extensive experience in studying immune related questions to aid pre clinical and clinical development of drug candidates utilizing a diverse set of assay technologies . My main interest is in the field of immuno oncology . . Technologies :",molecular glues;proteins;antibodies;nucleic acids;developing;engineering
"Research Assistant II Biophysics . Maintain and troubleshoot Talos Artica , Titan Krios , and Glacios cryo electron microscopes . . I have planned for a career in scientific research , laboratory management , and microscopy photon and electron . But life takes you in whatever direction it chooses and I also have experience in C and SQL software development .. Technologies : CryoEM",structure
"Bioinformatics Scientist . Led and implemented the entirety of the data analysis for two large scale random insertional mutant libraries in Chlamydomonas reinhardtii ; designed and implemented mutant screen sequence analysis pipelines ; advised other lab members on choosing statistical methods and experiment designs for their projects and performed statistical or other computational analyses for them ; co first author on two papers . . Bioinformatician with 10 years of data analysis and python programming experience in academic labs . Looking for new bioinformatics job opportunities , particularly in academia .. Technologies :",
"Scientist . . CMC lead for Developability assessment lead selection and biophysical charcterization scientist with several years of experience in industry and academic research in the fields of Protein Chemistry , Biophysics and cancer biology . Broad research experience in both biophysical and analytical techniques . Experience in scientific team management and collaboration , strategic thinking and planning , as well as project based management skills . Key interest in technology innovation , including development of new technologies , cancer research , formulation development and stability studies . Always curious about what drives human development and learning . . Technologies :",proteins;characterization
Senior Principal Scientist . . Back at Amazon working on optimization problems at scale on Amazon NA consumers .. Technologies :,
"Associate Professor . Principal investigator of research group comprising 10 scientists at various career stages . Part of interdisciplinary consortia PROMEMO memory and BOUNDLESS membraneless organelles . Teaching class on Physical Biochemistry , Proteins and their Interactions and Biomolecular Structure and Function . My research focus on dynamic and disordered proteins broadly defined . I am an expert on intrinsically disordered proteins , that is proteins without a fixed tertiary structure . Can be reached at : magnus mbg.au.dk We study the molecular mechanisms of disordered proteins , as well as their involvement in health and disease . We are trying to develop synthetic disordered proteins for applications in biotechnology , currently focusing on making new membrane less organelles for use in biosynthetic cell factories . My technical expertise lies in quantitative biophysics and biochemistry . We use a broad range of experimental techniques to characterize the activity , stability , structure , and interactions of proteins . I am the scientific coordinator of the Biophysics Core facility at the Department of Molecular Biology and Genetics , and serve as the point of contact for external users who wish to use our equipment . I am open to both academic and industrial collaborations within my overall field of expertise . Jeg formidler molekyl rbiologi p dansk med fokus p hvordan livets molekyler fungerer . Jeg holder foredrag under titlen Hukommelsens molekyler med udgangspunkt I forskningen ved grundforskningscenteret PROMEMO . Foredraget kan books under Forskningens D gn eller ved at kontakte mig direkte .. Technologies :",idps;proteins;characterization;engineering;interaction;stability;structure
"Bioinformatics Scientist . . Bioinformatics and machine learning scientist using computational statistical methods for analyzing sequence data . Working with next generation sequencing data in the context of germline and somatic variant calling , genotyping , and forensics , and developing software in these contexts . Expert in probability models , with applications in variant calling , forensics , phylogenetics and evolutionary modeling . Very strong background in machine learning and pattern recognition , including probabilistic graphical models , Bayesian statistics , dimensionality reduction , classification and clustering algorithms , and reinforcement learning . Excellent mathematical , statistical and computing skills . Development of scalable methods for large scale next generation sequence analysis . Experience analyzing diverse combinations of data sources . Programming : C C C , Java , Python , Matlab Octave , R , Perl . Fluent in linux command line and shell scripting tools . Experience with MPI and High Performance Clusters . Established track record in collaboration and mentoring . Developed several popular selection analysis tools available on the public web server , Data Monkey www.datamonkey.org , receiving over 10,000 page views per day . Extensive and highly cited publication list in bioinformatics computational biology . Also trained in speech recognition , natural language processing , spoken dialogue systems and digital signal processing , with highly cited publications in this area . Winner of the TWAS AAS Microsoft award 2010 for Young Scientists , recognizing out standing research in computer science conducted by African scientists that has , or promises to have , an impact in the developing world . . Technologies :",
"Senior Research Scientist . My job entails characterizing the biophysical properties of proteins and peptides in the earliest phases of research in the areas of diabetes and obesity . I work in multiple concurrent projects as a member of diverse teams where I contribute as an expert in biophysics , formulation pre formulation , physical stability , and characterization of protein and peptides . Current responsibilities include coordination and project management of department and area wide initiatives concerning automation and data science . . Biophysicist with 10 years experience with proteins , formulation , and biomolecules . Widely published . Emerging leader , passionate about facilitating and enabling excellence in teams working on complex and fascinating science challenges . Pushing the field forward with new measurements and analysis , towards new predictions and insights .. Technologies :",peptides;proteins;characterization;formulation
Principal Bioinformatics Scientist . . Computational scientist with 15 years of experience in algorithm and assay development . I like to work on research and early stage product development . I have provided leadership on projects to improve assays and develop pipelines for products that save lives .. Technologies :,
"Senior Scientist . Department Safety in the Food Chain Unit 84 , Feed and Feed Additives , led by PD Dr. Robert Pieper and Department Exposure Unit 33 , Epidemiology , Statistics and Mathematical Modelling led by PD Dr. Christine M ller Graf I am currently working with computer modeling for quantitative risk assessment of chemical contaminants in the food chain supply chain . My work spans all the way from programming numerical algorithms for computer simulation to translating scientific findings to make them useful to government officials assessing and managing chemical risks . I have many years of experience planning , leading and managing research projects involving several team members . . Trained by physicists . Anchored in chemistry . Enamored of biology . My career focus is on scientific research using computer simulations and mathematical modeling to understand complex systems at different time and space scales . I am most at home solving problems of medical , nutritional or environmental significance . Techniques : Pharmacokinetics , toxicokinetics and compartment models Scientific computing and numerical mathematics Information theory and statistical methods for data studies Molecular dynamics simulation and statistical mechanical modeling Examples of applications of my work until now : Toxicokinetics of chemical pollutants in feed and food Transfer modeling for undesirable substances in feed and foodstuffs Thermodynamics of protein folding and receptor ligand binding Conformational entropy estimation of beta amyloid aggregation in neurological diseases Calculation of dynamic modulation of pigment transition energies in photosynthesis Specialties : Development of modeling and simulation algorithms Thermodynamics and kinetics of complex systems Computer simulation of physical chemical biological systems . Technologies :",
Staff Bioinformatics Scientist . . . Technologies :,
"Doctoral Researcher . PhD thesis : ' Programmable DNA Origami Shell Platform for Virus Neutralization ' Focus on : Molecular design of artificial DNA nanostructures mimicking virus capsids with applications for virus neutralisation , drug delivery , and vaccination Characterisation of DNA nanostructures and proteins using cryogenic electron microscopy cryo EM , single particle electron microscopy tomography , helium ion microscopy HIM , enzyme linked immunosorbent assay ELISA , fluorescence resonance energy transfer FRET assay , and interferometric scattering microscopy iSCAT Molecular modelling with all atom and coarse grained molecular dynamic MD simulations Customised scripts for the design and analysis of DNA nanostructures Python , Bash , Igor Interdisciplinary collaborations including virologists , biochemists , and theoretical physicists : Project manager in the EU Horizon2020 research consortium VIROFIGHT : coordination calls , organising general meetings , and preparing deliverables with set deadlines Conducting DNA nanotechnology workshops for PhD students and postdocs at Brandeis University , Waltham Boston MA , USA Presenting at international conferences oral and poster My PhD research was awarded the ' Nano Innovation Award 2021 ' CeNS . . Technologies : CryoEM;FRET",carriers;proteins;structure
Neuroinformatics researcher software engineer . . . Technologies :,
"Industrial Liaison Engineer . . I am an enthusiastic and collaborative biocrystallographer . I always had a strong interest in developing better scientific methods and experiments to meet other scientists needs . This led me to be the scientific contact for the ESRF industrial clients of the MX , BioSAXS and Cryo EM end stations .. Technologies : CryoEM",
"Principal Bioinformatics Scientist . . I lead a Bioinformatics team working to significantly reduce greenhouse gas emissions . Using Systems Biology and the latest omics approaches , we engineer microalgae that use sunlight and carbon dioxide to produce biofuels and other molecules of high environmental impact . I split my time between hands on work at the computer and coaching mentoring team members pursuing a variety of tasks both in silico and at the lab bench . My primary interest is using computers to solve the most difficult challenges in biology . I have experience with the tools and methodologies for extracting the most knowledge from diverse data , including DNA sequence long short reads , whole genome , organelles , amplicons , RNA Seq Illumina PacBio , metagenomics shotgun amplicon , networks , and metabolic modeling . On the infrastructure side , I rely on technologies like Python , R Shiny , Docker , AWS , and SQL to rapidly push bespoke data analyses to scientists . Previously , I have worked on a wide variety of projects , including xenotransplantation , agricultural pest prevention , genome editing system discovery , synthetic biology software , and the application of high throughput proteomics toward human diseases CF and diabetes .. Technologies :",
"Senior Application Specialist Consultant trainer , EMEA CIS : Chromatography : DSP , Bioprocess . . Senior Consultant , Trainer and Application Specialist for whole portfolio of Purification chromatography products , for EMEA Russia CIS Turkey for customers scientists of pharmaceutical laboratories . Downstream Processing development and Bioprocess . In charge of the scientific on site and remote technical support : Consulting , training , protocol optimization , troubleshooting : on packing purification protocol , column packing expert . Lab , pilot production scales of biotech and pharma companies . In External internal training seminars hands on technical demonstrations on resins products . Besides customers training , intensive internal training of colleagues : Continuous punctual training of the whole european and asian purification sales team , 1o1 trainings on global sales cell culture team , training and close mentoring of new hired technical application support colleagues product and application related training Technical training of the european technical hotline team purification Regular soft skills and troubleshooting Trainings given to application support colleagues from diverse divisions : behaviour and logical thinking training to enhance relationship and support given to customers . Full execution delivery and complete organisation of the training : planning , lectures content set up , complete logistic detailed schedule , material lab set up , level assessment , theory training practical exercises , brainstorming , management of expectations questions , application consulting . . Downstream Processing of cytosolic and membrane proteins : Biochemistry characterisation , membrane filtration , purification by Chromatography HPLC : IEX RPC HIC MC AC SEC , on ETTAN SMART and above all KTA with the UNICORN software . Upstream Processing at labscale : molecular Biology , cloning in yeast bacteria , culture overexpression , activity assays radioactivity . Structural Biology of membrane proteins : crystallization , electron microscopy cryo EM and negative staining , Freeze fracture Specialties : training teaching consulting in Downstream Processing purification of biomolecules for laboratory scientists theory practicals project management , seminars organisation and presentation , writing continuous management of projects in 3 languages in parallel translation into German , English , French . Multicultural international environment . Languages : mother tongue : French , fluent in English German , basic knowledges in Russian and spanish . Lived and worked studied in France and Germany .. Technologies : CryoEM",
"Bioinformatician . Developing , managing and maintaining somatic cancer Next generation sequencing NGS pipelines for single nucleotide variant SNV , insertion , deletion , copy number variant CNV and structural variation SV calling while cooperating with Great Ormond Street Hospital as part of the North Thames GLH . The sequencing mainly performed on Illumina based sequencers such as iSeq , MiSeq , NextSeq and NovaSeq . The role also involves maintaining a SQL database as well as a Perl based web server for the submission of genomics analysis by wet lab staff . Furthermore , I am also involved in leading our quality ISO 15189 insepections for the bioinformatics team . . General I am an engineer specialised in bioinformatics that graduated from Uppsala University in Sweden . A native speaker in both Swedish and English and also fluent in Spanish after my time in Universidad de Deusto in Basque Country , Spain . During my time studying , I have involved myself in various extracurricular activities , such as being a part of different boards , research projects etc . I am a motivated individual that is always interested in stepping into a new challenge in order to become better at what I do . As I have a bachelor in biotechnology and a masters in bioinformatics , I have experience from both dry and wet lab environments . I am not afraid to enter unknown fields topics as long as I am given the opportunity to develop . In my time in Uppsala University , I was a project leader of a student driven research project as well as president and member of different boards . Such activities have made me improve working in a team and helped me understand the dynamics of how to be a good team leader . Work My work has mainly focused on clinical bioinformatics where I have developed pipelines for both analysing DNA and RNA from Next Generation Sequencing data to detect single nucleotide variants , indels insertions deletions , copy number variations and structural variations . Coding experience The main programming languages I use and where I have expert experience are Python , R , Bash and MySQL while I have intermediate experience with HTML , CSS and Latex . I am also a frequent user of Linux based terminals and have limited knowledge of Windows DOS . Workflow mangers container technology I predominantly use NextFlow but I have also used Snakemake . In the case of container technologies , I have experience with both Docker and Singularity . . Technologies :",
". . I am a patient and advocate for people with myalgic encephalomyelitis ME , aka CFS , SEID . I use my scientific background and personal experience with ME to educate the medical and researcher communities about the disease . I am also a yoga teacher . I draw upon a wide range of yoga styles and traditions to help all people achieve a sense of internal and external ease and stability . As a research scientist , my work has been focused on protein structure and function . I have used X ray crystallography , cryo electron microscopy , stopped flow spectroscopy , Biacore , and other techniques to answer questions about virus structure and enzyme mechanism .. Technologies : Xray;CryoEM",proteins;formulation;structure
"Doctoral Candidate . PhD researcher position at the Daumke Lab of the Max Delbr ck Center for molecular medicine of the Helmholtz Society . My projects focuses on structural studies of mitochondrial membrane associated complexes . Protein X ray crystallography Protein cryo EM HPLC for protein purification using an automated Agilent HPLC pipeline and KTA pure FPLC Purifier . Originally from Greece , now a PhD student at the AG Daumke of the Max Delbr ck Center in Berlin . Previously a biochemistry postgraduate student at the University of Oxford and an undergraduate DAAD scholar based in the Freie Universit t Berlin . Within biochemistry intrigued by membrane and inflammatory signaling and the use of structural biology to study them . Passionate about project management and community building within biosciences and interdisciplinarily with other sectors with the goal of expanding and diversifying the discource in life sciences . Contact : nathanailevaggelia at gmail.com . Technologies : Xray;CryoEM",proteins;interaction;structure
Senior Research Software Developer . . . Technologies :,
"Principal Scientist . . I 'm passionate about using my background in computer science and machine learning to help improve human health and fight disease . I love working in vibrant , inter disciplinary , and highly collaborative teams . I have extensive experience developing machine learning algorithms , analyzing NGS data , and leading cross functional collaborative projects in the fields of rare disease diagnosis , epigenomics , synthetic biology , and immunotherapies . I also love sharing my passion about computer science , genomics , and STEM education through activities such as mentoring and college outreach .. Technologies :",
"Bioinformatician . . Applied mathematics graduate , looking to pursue a career in medical research and development using theoretical and computational methods . Recently finished studying a biomedical engineering degree at The University of Sheffield : Computational Medicine MSc . A pioneering area of healthcare engineering , MSc Computational Medicine is teaching a new generation to become digital specialists in computer modelling for disease diagnosis , treatment and prevention . Taught by in silico medicine researchers and experts from the Insigneo Institute . https : insigneo.org msc computational medicine 2019 . Technologies :",
"Principal Scientist Head of Laboratory Project Leader . . I am a biomedical research scientist with extensive experience in project design , lead and management in academia , medical research centers and industry . I have 15 years of scientific expertise in cancer biology and oncogenic signaling with 10 years of experience in preclinical target identification , validation and drug discovery . In my current position , I am a Principal Scientist leading a lab in the Molecular Targeted Therapy Department , Discovery Oncology , Roche pRED . We work on Drug Discovery and Biology of tumor cell intrinsic as well as cancer immunotherapy targets . We develop small molecules , bifunctional degraders aka PROTACs and molecular glue degraders to advance and expand therapy options for cancer patients with high unmet medical need . I am also Project Leader of multifunctional Drug Discovery Programs and have expertise in the development of advanced cellular assays for HT screening . My experience and skills include : Expertise in oncogenic signaling and mechanisms of metastasis Targeted Therapy and Translational Cancer Research Lead of Drug Discovery Project , Target Identification , Target Validation , HT Assay Development High throughput genetic and phenotypic screening approaches and their analysis 2D and 3D assay development for medium and high throughput screens Track record of successful basic , preclinical and drug discovery project management Strong strategic thinking , long term planning and goal setting skills Experienced in lead and management of cross functional and global matrix teams Enthusiastic initiative scientist with a result oriented and well organized personality Concise communicator with strong written and verbal presentation skills Interactive team player with excellent interpersonal and people management skills . Technologies :",molecular glues;small molecules;interaction;screening
"Visiting Scientist . Apply various biophysical characterization techniques in particular Cryo EM , FTIR , Raman , DLS , Fluorescence spectroscopy , NMR , and DSC to characterize protein , Nucleic acid , Viral particle for gene therapy , and to support understanding biotherapeutic products and bioprocess development . Perform method development and comparability study for different products including mRNA vaccine , LNP , and AAV . Collaborate with multiple groups to investigate and to interrogate RNA structure at single nucleotide resolution performing RNA chemical modification , Reverse Transcription and second strand synthesis . . PhD in chemical engineering with focus on nanomaterial synthesis and characterization for better understanding their shape , size , and structure dependent properties . 2 years postdoctoral experience at Washington university in St. Louis MO . Conducted 3 projects independently and 3 projects as a member of collaborative projects . 8 years of experience in chemical engineering specializing in semiconductor material and thin films for different energy conversion applications such as for solar cells and for CO2 photo reduction . Extensive experience working on collaborative projects 10 projects and ability to work individually 6 projects . Winner of 3 Awards and scholarships . 40 publications and conference presentations . 1000 citations . Technologies : CryoEM;SLS DLS;DSC;NMR",biologics;carriers;nucleic acids;proteins;characterization;structure
"Computational Chemist I . . Successfully lead drug design projects with medicinal chemists , biochemists , and pharmacologists . Experience with various computational and X ray crystallography tools for hit discovery , hit to lead , and lead optimizations . Computational molecular design and drug discovery Schr dinger suite , MOE , Cresset , CCDC suite etc Protein modeling , molecular dynamics , FEP , structural bioinformatics AMBER , DESMOND , MODELLER X ray crystallography refinement of protein ligand complexes Phenix suite , Coot , CCP4 Virtual screening , QSAR , pharmacophore modeling , virtual chemical library design Hybrid Quantum Mechanics Molecular Mechanics calculations Gaussian ONIOM Cheminformatics : Chemical data management , clustering , and analysis . Data analysis , deep learning , and predictive modeling R , Python , SQL , DeepChem In silico ADME Tox predictive modeling and analysis Publications : Mahasenan , K. V. et al . ACS Chem . Biol . 2020 , DOI:10.1021 acschembio.9b00754 Mahasenan , K. V. et al . ACS Med Chem Lett 2018 , DOI:10.1021 acsmedchemlett.8b00163 Bernardo Garcia , N. ; Mahasenan , K. V. , et al . ACS Chem Biol 2018,13 3 694 Acebr n , I. ; Mahasenan , K. V. et al J Am Chem Soc 2017,DOI:10.1021 jacs.7b01626 Mahasenan , K. V. et al . ACS Med Chem Lett . 2018,11;9 7 708 , DOI:10.1021 acsmedchemlett.7b00130 Mahasenan , K. V. et al . J Am Chem Soc 2017,139 5 2102 , DOI:10.1021 jacs.6b12565 Leemans E , Mahasenan K. V , et al Bioorg Med . Chem . Lett . 2016,26 3 : 1011 5 Alinari L , Mahasenan K. V. et al Blood 2015,125 16 2530 Mahasenan , K. V. and Li , C. J. Chem . Inf . Model . , 2012 , 52 5 , pp 1345 1355 Mahasenan , K. V. et al . ACS Med . Chem . Lett . , 2011 , 2 11 : 855 860 . Equal contribution . Commun Biol . 2022 , 28;5 1 395 Comput Struct Biotechnol J. 2021,17;19,5392 ACS Omega . 2021 , 20;6 30 19983 . Acc Chem Res . 2021 , 16;54 4 917 J Med Chem . 2020 , 28;63 10 5287 Nature Communications 2019 , 5;10 1 5567 Antimicrob Agents Chemother . 2019,25;63 5 e02637 PNAS 2018,24;115 17 : 4393 Sci Rep 2018,8 1 4110 Structure 2017,25 2 295 ACS Chem Neurosci . 2016,7 11 1482 Structure 2016 24 10 1729 ACS Chem Biol 2016,11 6 1525 ACS Chem Biol 2014,9 9 2058 J Biol Chem 2014,289 13 9275 J Med Chem 2013,56 20 8139 J Biol Chem 2013,288 17 12114 J Biol Chem 2013,288 11 7430 J Nat Prod 2013,76 3 311 ACS Chem Biol . 2012,7 4 761 J Med Chem 2011,54 24 8681 J Med Chem 2010,53 3 966 J Chem Inf Model 2009,49 6 1581 Chem Biol Drug Des 2008,71 5 501 Bioorg Med Chem 2007,15 18 6071 Bioorg Med Chem Lett 2006,16 23 6013 . Technologies : Xray",
"Research Scientist . . I am currently investigating the relationship between the physical properties of active pharmaceutical ingredients such as insulin and process steps . The aim is to increase the stability of these active proteins , thereby reducing storage requirements and allowing broader distribution while also potentially reducing negative side effects . I have recently investigated the kinetics of formation and structural intermediates during viral capsid protein self assembly through the use of small angle scattering time resolved , X ray and neutron TR SAXS , SANS and cryo electron microscopy cryoEM as a postdoc researcher in the Andr Lab at Lund University 's Department of Biochemistry and Structural Biology . Another previous position was as an instrument postdoc with the Bio SANS instrument team of the High Flux Isotope Reactor HFIR at Oak Ridge National Lab ORNL , where my primary scientific focus was on membrane protein systems and contrast matching detergent micelle contributions , in addition to serving as an instrument scientist and local contact to support the General User Program . With classic training as a chemist , I support an analytical and measured approach to all problems . My interests lie in biology unique and complex systems that have direct applications to our own health and understanding . This motivation drives a necessity to for a physical understanding of the basis of measurement techniques and biomolecular probes , and a knowledge of computational approaches which have greatly accelerated recent developments in these areas .. Technologies : Xray;CryoEM",membrane proteins;proteins;stability;structure
Bioinformatics Scientist . . . Technologies :,
"Junior Specialist Lab Manager Rosenblum Lab . . Hello My name Gabriella Tenorio and I 've graduated with my Bachelor of Science in Microbiology and minored in Computing Applications from San Francisco State University . During my time as an undergraduate , I have worked in a computational biology laboratory researching fitness costs and HIV 1 infected pregnant women using the programming language R .. Technologies :",
"Director , Computational Biology . Lead a computational biology team with over a dozen PhD researchers , providing translational bioinformatics supports across oncology , GI , NS and rare disease therapeutic areas . Support Takeda s clinical programs : accountable for omics clinical biomarker data QC , process , and clinical database deposit ; collaborate with translational science , biostatistics , clin pharm and other teams on supporting clinical programs exploratory analysis and translational research efforts ; utilizing AI ML approaches for drug sensitivity predictions . Work closely with Takeda s drug discovery colleagues to provide computational supports on new target identification and validation . Connect and collaborate with teams across Takeda sites and functions . Method evaluation and pipeline building for data process , analysis , and integration , including WGS WES , RNAseq , Nanostring , and other types of data . Provide computational support on collaborating partnership projects , e.g. Open Target , Moffitt M2GEN , Genomic England , CBDD , and collaborate with academic field exports . Invited talks on scientific meetings : Bio IT World , 2020 , Virtual meeting . 2nd AI ML Clinical Development Pharmacovigilance Congress , 2019 , Boston , MA Bio IT World , 2019 , Boston , MA 4th Annual Next Generation Sequencing and Clinical Diagnostics Single Cell Analysis USA Congress , 2018 , Boston , MA keynote speech Bio IT World : W11 Data Science Driving Better Informed Decisions , 2018 , Boston , MA Invited talk EBI Workshops on Predictive Modeling of Biomarker , 2017 , Cambridge , MA co organizer , host , and oral presenter Biomarker Summit 2017 , San Diego , CA 5th International Conference on Biometrics Biostatistics , 2016 , Houston , TX keynote speech and section chair Biomarkers Diagnostics world congress 2016 , Philadelphia , PA AAPS National Biotechnology Conference , 2016 , Boston , MA Biomarkers Diagnostics world congress 2015 , Philadelphia , PA NGS Pharma meeting , 2013 , Frankfurt . Lead a computational biology team with over a dozen PhD researchers , providing translational bioinformatics supports across oncology , GI , NS and rare disease therapeutic areas . Support Takeda s clinical programs : accountable for omics clinical biomarker data QC , process , and clinical database deposit ; collaborate with translational science , biostatistics , clin pharm and other teams on supporting clinical programs exploratory analysis and translational research efforts ; utilizing artificial intelligence and machine learning AI ML approaches for drug sensitivity predictions , patient stratification and disease indication selections . Work closely with Takeda s drug discovery colleagues to provide computational supports on new target identification and validation . Perform data analysis and integrate internal and public domain data , supporting drug discovery efforts from project start , target validation , portfolio entry , development candidate selection , to IND . Connect and collaborate with teams across Takeda sites and functions , including drug discovery units , therapeutic area units , exploratory biostat , translational research , early target discovery , and other teams , to support forward and reverse translational research . Develop new computational methods for patient stratification and disease indication selection . Method evaluation and pipeline building for data process , analysis , and integration , including WGS WES , RNAseq , Nanostring , and other types of data . Provide computational support on collaborating partnership projects , e.g. Open Target , Moffitt M2GEN , Genomic England , CBDD , and collaborate with academic field exports . . Technologies :",
"Associate Computational Biologist . Worked on antibody docking and structure prediction for antibodies using modeling softwares Performed ChIPseq data analysis to look at TF motif enrichment and single nucleotide resolution cut profile Detected alternate splicing events which helped suggest the PBM interaction requirement for PRMT5 dependent splicing events . Processed and analyzed data for Paralog CRISPR screens for multiple collaborations to find actionable biomarkers Helped analyze data from mass spectrometry experiments conducted to identify novel E3 substrates . Born and raised in India , I have received my Bachelor of Technology in Computer science and engineering at IIIT Delhi and graduated with a Master of Science in Bioinformatics degree at Georgia Institute of Technology . I am a driven , hard working individual who is seeking to gain knowledge and experience in the bioinformatics field .. Technologies :",
NERSC Strategic Partnerships Lead . Growing the impact of computational science . . I collaborate with science teams seeking powerful scientific computing and data capabilities . Partnerships in computational science can accelerate research agendas by leveraging the scale and speed of HPC . Helping science go faster with parallel computing algorithms and architectures is interesting to me .. Technologies :,
"Bioinformatics Support Scientist . . Passionate leader of both software and cross functional teams . Consistent record of on time , on quality product development . Effective communicator at all levels : Senior Management , project and technical teams , customers , and collaborators Development Management for medical devices and systems for the life sciences Embedded systems , scientific applications , and algorithm development Demonstrated resilience to changes in scope , resource availability , and technical challenges KEY ACHIEVEMENTS Led development of 454 GS FLX v2.8 next gen sequencing NGS instrument to reliably deliver 1000 base pair reads and extend commercial life of product . Developed newbler DNA sequence assembly and mapping software . Managed early adopters in academia and industry Developed prototype software for several DNA sequencing applications working with internal and external customers to define requirements and validate solution . Led development of basecalling algorithms for commercial capillary electrophoresis DNA sequencer Contact Information : rwiner44 gmail.com . Technologies :",
"Computational Biologist and Bioinformatics Scientist . Work for Computational Genomics group to contribute efforts to synthesize , define , and broadly deploy genomics data and methods in support of global drug discovery and development programs at Merck . Running , wrote and updating Tumor Mutational Burden TMB pipeline from thousands of patient 's whole exome sequencing WES data . Work on Next generation DNA sequencing technologies : Help to setup automated short read sequence application pipeline . Comparison of performance , sensitivity , selectivity , features and limitation of short read sequence analysis algorithms such as Bowtie2 , Star , HiSat2 , BWA , minimap2 , samtools . Work closely with scientists in the Oncology and Immuno Oncology therapeutic area to process and analyze biological data sets from NGS sources such as DNA seq WES WGS , Chip seq ATAC seq , RNA seq . Familiar with data visualization platforms such as UCSC genome browser , QIAGEN 's OmicSoft , JBrowse , cBioprotal , partek flow , IGV , etc . Support custom data processing for all platforms . Design and write source code pipelines for small interfering RNA siRNA , Small hairpin RNA shRNA , anti sense oligo ASO and single guide RNA sgRNA . Help write SNP INDEL CNV sequence analysis pipelines from software such as GATK and custom tools . Implemented in grid engine . Whole new genome analysis for : Pichia pastoris biologics production , published 2015 , Insect Genome annotation with tools like AUGUSTUS , interproscan , etc . To contribute to Data System , which is a centralized resource for genes , proteins , networks , and pathways that integrates data from public and proprietary sources . . . Technologies :",
"Head of Applications . . Throughout my academic career I focused on the reconstitution and analysis of biologically relevant protein or protein nucleic acid complexes . During my PhD , I used biochemical and biophysical approaches to shed light on bacterial transcription regulation and DNA organization . At EMBL during my Postdoc , I used protein biochemistry , single molecule light microscopy and cryo Electron Microscopy to understand how cells regulated their cytoskeleton . At CRG , my laboratory wants to understand how neurons can define their local proteome , a mechanism essential for neuronal function and long term memory formation . Specifically , we aim to discover how mRNAs are distributed to axons and dendrites , which is the prerequisite for local protein production . We first focused on the development of novel , NGS coupled , high throughput interaction screens that can detect direct protein protein interactions within libraries or between protein libraries and RNA fragment pools . We have used this technology to reveal how neuronal mRNPs are coupled to the microtubules based transport machinery . In parallel , my lab remained strongly focused on protein biochemistry . Based on interactions indicated by high throughput screening , we aim to reveal the mechanochemistry that generates neuronal mRNA distribution patterns . To this end , my lab produces the required building blocks of these transport complexes by recombinantly expressing and purifying the required mammalian multi protein complexes and RNAs . Through bioanalytics and microscopy coupled live biochemistry approaches , we are currently studying how cells can transport the right specifies and amount of mRNA to the right cellular location .. Technologies : CryoEM",nucleic acids;proteins;interaction;screening
"Cancer Genomics Research Associate . Spearhead scripted analyses of the FoundationCore database as primary python and R developer on over 36 inquires for our chief biopharmaceutical partner . Lead bioinformatics research on oncogenic synthetic lethality , rapid database wide patient to patient similarity scoring , harnessing off target sequencing reads for expanding biomarker detection , and enabling parent of origin calling for deleted chromosomal segments . Oversee documenting of FoundationCore , our repository of over 200 specimen variant level data fields for 400,000 patients ; tasked with defining , scoping , and programmatically validating all information used for investigational research and data product development . . Computational Biologist . Technologies :",
"Senior Bioinformatics Scientist . Basic research for early drug target discovery at Exploratory Science Center . I am an enthusiastic and energetic computer programmer specializing in mathematics and bioinformatics . As a Bioinformatician at Yale School of Medicine Child Study Center , I Analyzed data to support hypothesis that WNT pathway gene expression in early brain development is important for autism Designed oligonucleotides for in vitro assessment of enhancer activity in organoids Implemented new computational workflows to streamline analysis of sequencing data Computed the noncoding regulatory network explaining the trajectory of frontal cortex development in neurotypical and ASD individuals I graduated in 2019 with a PhD from the University of Pennsylvania in Genomics and Computational Biology . My dissertation provided new computational tools for handling data heterogeneity in large RNA seq datasets for splicing analysis in order to further both basic biology and medical research . I believe that more information and deeper analysis will improve the diagnosis and treatment of disease . My doctoral dissertation was enabled with Python , MATLAB , R , C , C , and Bash .. Technologies :",
Professor . . Specialties : Computational genomics . Alternative splicing . RNA surveillance . Nonsense mediated mRNA decay . Personal genome interpretation . Metagenomics . Bioinformatics . Structural genomics . Protein structure . Protein function prediction . RNA structure . RNA function . Phylogenomics . Structural biology . Evolutionary biology . Computational biology . Education training . Note : I log into LinkedIn only once every year or two . Please email brenner compbio.berkeley.edu rather than LinkedIn messaging .. Technologies :,
"Research Scientist . Elucidated to reconstitute and solve the structure of STRIPAK PP2A core complex in Hippo Pathway using Cryo EM single particle reconstruction . . Single Particle Cryo EM electron microscopy Operation of FEI Titan Krios Talos Arctica Data Analysis for Cryo EM and Negative Stain Data Processing X ray Crystallography A lot of experiences in X ray data collection for crystals of protein and protein nucleic acid complex using Synchrotron source Pohang Light Source S. Korea , Photon Factory Japan , Spring 8 Japan and APS US Proficient in crystal handling surgery , seeding , dehydration , heavy atom derivative , cross linking Expertise in Computational tools Familiar with Windows UNIX Linux operating systems software Phaser , Molrep , ARP wARP in CCP4 suit , CNS , Solve Resolve , PHENIX system , Coot , Aline , ESPript , HKL2000 , EMAN2 RELION , etc Expertise in the operation of Biophysical tools FPLC and HPLC for the column chromatography affinity , ion exchange and size exclusion ITC Isothermal Titration Calorimetry for the interaction of protein peptide or protein nucleic acid MALS multi angle light scattering for determining the absolute molar mass Spectrophotometer for UV Vis , FI , FP , TRF Lum Operation of Hydra II , The Crystal Gryphon Mosquito for protein crystallography screening Expertise in Biochemistry Protein over expression system E. coli , Baculovirus HEK 293 Vector design reconstruction , and LIC Ligation independent cloning , ex , Gibson cloning Design of Experiments in vitro assay system Improvement of stability or solubility of protein EMSA the gel electrophoretic mobility shift assay Footprinting assay for DNA or RNA In vitro transcription and In vitro translation . Technologies : Xray;CryoEM;ITC;SLS DLS;FP",nucleic acids;proteins;interaction;stability;structure
"Bioinformatician I . Bioinformatician in the O'Donnell Luria lab at Boston Children 's Hospital . . I am interested in computational biology , bioinformatics , data science , and using computation to bridge the gap between research and healthcare . Topics that interest me include genomics , protein folding , blockchain and cryptocurrencies , and IoT devices .. Technologies :",
"Volunteer , Science News Writer . . . Technologies :",
"Secondment Project Research Scientist at AstraZeneca . I have been awarded the UKRI UK research and innovation award to start a secondment at AstraZeneca applying high throughput screening of small molecule libraries to identify compounds that block the interaction of RAS with one of its downstream effectors p110 a member of the PI 3 kinase family . . My work centres on several cancer drug discovery projects , in collaboration with pharmaceutical and academic institutions , all with the aim of targeting RAS signalling in cancer . These projects involve assay development and early hit characterisation using different modalities with a focus on small molecules and cyclic peptides . Below is a summary of the projects and collaborations I am working on and managing : Screening tool development : I was awarded an Crick ideas to innovation i2i grant to collaborate and work with AstraZeneca AZ to screen small molecules that inhibit the RAS PI3 K protein interaction . I worked in AZ laboratories in Cambridge with the assay experts to develop a screening assay that is suitable for the RAS PI3 K interaction . Through this work I actively engaged with Promega to collaborate and successfully reverse engineer a commercially available cellular screening assay for use as a cell free biochemical tool , which I named the NBBA Nano BiT Biochemical Assay . In March 2021 , received a UKRI UK research and innovation award to start a secondment at AstraZeneca applying high throughput screening of small molecule libraries to identify compounds that block the interaction of RAS with one of its downstream effectors p110 a member of the PI 3 kinase family . Early hit identification PROTAC development : I was awarded 12 months of Crick translational funding i2i , assigned for the development of early ideas with translational potential , to identify small molecule fragments which could differentially bind to specific KRAS isoforms ; the ultimate aim of developing warheads for isoform specific PROTAC approaches . I worked closely with GSK scientists embedded at the Crick and hired CRO Domainex to apply in silico fragment screen . This work is currently in progress . Early hit identification Cyclic peptides : I collaborated with colleagues at Southampton University to screen cyclic peptide libraries that could potentially block the RAS PI3K. In this project , we used a technique called SICLOPPS Split Intein mediated Circular Ligation of Peptide and Proteins . I developed and improved the screening assay for high throughput screening . I discovered a specific cyclic peptide that inhibits the RAS p110 interaction . I am currently writing up the manuscript for publication .. Technologies :",molecular glues;peptides;proteins;small molecules;interaction;screening
"CR1 HDR . Study of the physico chemistry of collagen I liquid crystal phases . Synthesis of collagen matrices mimicking living tissues bone , tendon , cornea Electron and Cryo electron microscopy . Th matiques de Recherche Macromol cules biologiques et leurs assemblages organis s : cristaux bidimensionnels ou cristaux liquides et matrices organis es . Etudes de l'effet des param tres physico chimiques pH , force ionique , la nature de l'acide sur les phases cristal liquide du collag ne I constituant majoritaire des matrices extracellulaires . Techniques par microscopie lectronique et photonique lumi re polaris e et multiphotons collaboration LOB , Palaiseau . ou et RMN collaboration LCMCP , Paris . Proc d s de polym risation et de mise en forme des polym res et de leur assemblage afin d obtenir des biomat riaux pour des applications m dicales . D veloppement d une corn e artificielle Contrat FRM DCM20121225759 . D veloppement d'un tendon artificiel . Pansement pour la d livrance de produits actifs . . Technologies : CryoEM",structure
"Senior Computational Chemist . Computational chemistry , cheminformatics , system administration and user support in the section for Biostructural Research . . Competent and inventive researcher with good collaboration skills . My background as MSc Pharm . provides me with an overview of the drug discovery and development process , which eases communication with colleagues and collaborators with different backgrounds and expertises . I have worked within computational medicinal chemistry since I started my PhD in 2003 and gained extensive experience with most molecular modeling techniques . I have experience with multidisciplinary drug discovery projects in close collaboration with medicinal chemists , molecular pharmacologist , structural biologists and data scientists from both academia and industry . I have worked in the interface between molecular modeling and other fields of research and one of my key roles have been to interpret experimental data in a structural context and suggest new experiments and compounds based on structures and models of ligand protein complexes . In recent year my focus has changed from traditional small molecule ligands to peptides as agonists of GPCRs and inhibitors of downstream signalling pathways . Specialties : GPCRs , G proteins and ligand gated ion channels . Most computational chemistry and molecular modeling techniques . Structure based design of peptides and small molecule ligands Linux system administration and user support . Teaching at the university level I am part of the Gloriam Group gloriamgroup.org , which has G Protein Coupled Receptors GPCRs as the main research focus . Additionally , we host the GPCRdb gpcrdb.org , which contains reference data , interactive visualisation and experiment design tools for GPCRs . GPCRdb curates sequence alignments , structures and receptor mutations from literature . Interactive diagrams visualise receptor residues e.g. snakeplot and helix box plot and relationships e.g phylogenetic trees . Join the GPCRdb LinkedIn group https : www.linkedin.com groups GPCRdb 8104679 about to be updated on new releases , publications etc .. Technologies :",
"Scientist . . In vitro pharmacology scientist with extensive experience in in vitro assay development , high throughput screening , biochemical assays , and antibody characterization . Successfully worked in group settings and collaborated with different groups within the company . Helped establish and manage the lab . A high performing scientist who is detail oriented , adaptable and a team player .. Technologies :",antibodies;characterization;screening
"Postdoctoral Fellow . . I am very experienced in biochemistry , cell biology , molecular biology , structural biology X ray crystallography and cryo EM , and epigenetics . I am also experienced in membrane and soluble protein biology . My long term career goal is to establish my own research program as an independent investigator , focusing on decoding the crosstalk between DNA methylation , histone modification , and histone writers readers using structural and cell biological approaches . I also pursue to leverage the mechanisms and regulations of DNA methylation on chromatin to develop human therapies to treat cancers .. Technologies : Xray;CryoEM",proteins;structure
"Doctoral Researcher . Developing image processing tools for cryogenic electron microscopy data : single particle analysis SPA and tomography cryo ET Implementing and maintaining software packages open source based on mathematically advanced algorithms and parallel processing schemes MPI and CUDA Combining signal processing with tools from different fields for cryo EM data analysis such as Normal Mode Analysis NMA , Molecular Dynamics MD simulations , Optical Flow , Machine Learning , Dimensionality Reduction , etc Communicating and working closely with biologists daily interaction for data collection , methods employability and results interpretation My thesis is funded from 2 ANR projects the French Agency for National Research . On going PhD in BioImage Informatics Electronics engineer with two masters in science and technology Skilled in image signal processing , machine learning and programming . Technologies : CryoEM",
"PhD Graduate Student . . US Army veteran that graduated with a Bachelors of Science in Biology from the University of Missouri Kansas City . Currently I am working on my PhD in Biophysics under Dr. Timothy Grant at the University of Wisconsin Madison . The Grant lab collaborates with research groups across campus to solve challenging protein structures using single particle Cryo Electron Microscopy Cryo EM . To meet the challenge of these samples , we are often resort to developing novel methods in computation and sample preparation . My long term goal is to conduct research using Cryo EM in an industrial or academic setting using interdisciplinary approaches to study the structure and function of proteins .. Technologies : CryoEM",membrane proteins;characterization;structure
Principal Scientist . . . Technologies :,
"Staff Scientist , BioInformatics . I am a part of the Bioinformatics Applications Development team at PacBio . Our team goal is to facilitate interaction between internal and external collaborating scientists in the development of cutting edge applications for next generation genetic sequencing technology . My specialty is in targeted sequencing and assay development . I work closely with groups of other scientists to bring products to market . . Experienced Staff Scientist with a demonstrated history of working in the biotechnology industry . Skilled in Sequence Analysis , DNA Sequencing , Bioinformatics , Python , Assay Design for rare diseases , and Evolutionary Biology .. Technologies :",
Senior Scientist . . . Technologies :,
CRTA Post bac Fellow . Developing algorithms to improve the quality of cryo electron microscopy images . . I plan on applying to physics PhD programs in the fall of 2022 .. Technologies : CryoEM,
Assistant Professor . Computer Science Research and Teaching . Combining bioinformatics and data science in AI and deep learning research and education . . I am an experienced educator in the field of informatics with a passion for solving complex real life problems using data driven decision making process .. Technologies :,
"Senior computational scientist . . Interests in genomics of complex diseases , bioinformatics , systems biology , statistics , genetics , molecular medicine , OOP , OOD , software architectures , project management , agile methods , intelligent systems .. Technologies :",
Research Fellow . . . Technologies :,
"Senior Scientist . . Protein scientist with experience in engineering proteins , production , characterization , and determination of the high resolution structure using X ray crystallography . Current focus is on antibody discovery and engineering for cancer immunotherapy and neurodegenerative diseases .. Technologies : Xray",antibodies;proteins;characterization;engineering;structure
Quantitative Analyst . . Researcher in machine learning .. Technologies :,
"Directorial Board of PSI . The Paul Scherrer Institute , PSI , is the largest research centre for natural and engineering sciences within Switzerland . We perform world class research in three main subject areas : Matter and Material ; Energy and the Environment ; and Human Health . By conducting fundamental and applied research , we work on long term solutions for major challenges facing society , industry and science . . Prof. Gebhard Schertler , PSI ETH Z rich , is investigating G protein coupled receptors GPCRs . When the group was located at the MRC Laboratory for Molecular Biology Cambridge , UK , they focused on 3D structural analysis by X ray and electron crystallography and solved the atomic structures of GPCRs rhodopsin , beta adrenergic receptors . With this expertise , Schertler and his team successfully revealed the mechanisms of light induced rhodopsin activation Prof. Gebhard Schertler , PSI ETH Z rich , is investigating G protein coupled receptors GPCRs . When the group was located at the MRC Laboratory for Molecular Biology Cambridge , UK , they focused on 3D structural analysis by X ray and electron crystallography and solved the atomic structures of GPCRs rhodopsin , beta adrenergic receptors . With this expertise , Schertler and his team successfully revealed the mechanisms of light induced rhodopsin activation and agonist binding to a GPCR . Since his move to the PSI in 2009 , Schertler established an interdisciplinary research group on GPCRs , including crystallography , electron microscopy , NMR , biophysics and bioinformatics and a platform for protein expression purification crystallization . He is also responsible for biological applications on the Swiss Free Electron Laser SwissFEL and is involved in the experimental setup and design of biology beamlines for optimization of both biomolecular ocrystallography and biological X FEL imaging . He is heading the Department for Biology and Chemistry at the Paul Scherrer Institute PSI and he is Professor for Structural Biology at the ETH in Z rich , Switzerland . Since 2011he is in the Directorial Board of the Paul Scherrer Institute , this is the largest research institute in Switzerland . Specialties : Membranprotein Crystallisation . Microdiffraction . Femtosecond Second Crystallograph . X FELs . G Protien Coupled Receptors . Complex Neural Connections in the Retina . Technologies : Xray;NMR",membrane proteins;expression;screening;structure
"Associate Professor . . Specialties : cryo electron microscopy , image processing , biochemistry , bioinformatics . Technologies : CryoEM",proteins;structure
"Principal Research Associate . I am working as a Principal Research Associate on evaluating new Antibody Drug Conjugate technologies ADC 's and screening of innovative new targets to utilize their internalizing properties for payload delivery . . After six years of experience as a normal Works Council Ondernemingsraad member , I have taken up the responsibility and currently am chairman of the Genmab B. V. Works Council . This during exciting times of transforming from small biotech to a profitable company preparing for launching its own product . During this process of adding commercial disciplines and growth there is a strong focus on globalization of the organization . . Principal Research Associate Chairman of the Works Council Ondernemingsraad . Technologies :",antibodies;screening
"Of Counsel . Patent Attorney . Scientific Experience , Structural Biology , especially NMR cf . NMR Script for Biochemist of the University of Frankfurt , X Ray Cristallography cf . Cell Structure paper , Cryo EM Diploma Thesis , Molecularbiology , Biotechnology , Immunology Developmental Biology PhD Thesis , Pharmacology addional subject at university , Bioinformatics development of a tachistoscope simulator , IP Experience , Patent Litigation , nullity and infringement actions as far as BGH , opposition and appeal proceedings before the EPO , Patent Prosecution , all levels of grant procedure , specialized in patenting second medical use applications i.e. viral vaccines , pharmaceutical and cosmetical protein and peptide formulations , medical diagnostic methods based on molecular biology methods , development of new adjuvants . Patent Consultance Freedom to Operate Analysis , Patentportfolio Management , Counsel in Patent Trading , Counsel in early development processes .. Technologies : Xray;CryoEM;NMR",
"Scientific leader Programme SLP . . Experienced research assistant with skills in transmission electron microscope , cryo EM , high performance computing , molecular dynamic simulation , shell scripting , molecular cloning , circular dichroism , high performance liquid chromatography , mass spectrometry . Message are welcome . : . Technologies : CryoEM;CD",proteins;structure
"Head Of Clinical Operations . . I completed my PhD at the University of Zurich in the group of Prof. Markus Seeger , where I studied the biochemistry and structural biology of siderophore transport . During my PhD I had the opportunity to learn different experimental methods , including X ray crystallography , Cryo EM and NGS . In 2018 I started a position as head of clinical operations in the Molecular Tumor Profiling Lab of the University Hospital Zurich , where I am directing the clinical efforts of the lab . In parallel to my current position , I am studying to earn a Msc . in Business Administration MScBA to further develop my carrier .. Technologies : Xray;CryoEM",
"Senior Lecturer in Computational Biochemistry . . Biomedical researcher , with several years postdoctoral experience including several positions with team leading responsibility . Especialized in Computer aided drug design and structural bioinformatics , several collaborations established with both academia and biopharmaceutical sectors . Currently Senior Research Fellow at Uppsala University . Present Goals Structural modeling and molecular simulation in G protein coupled receptors GPCRs . See GPCR ModSim web server at http : gpcr.usc.es Implementation of binding free energy calculations in the pipeline of Virtual Screening and CADD . Application of Structural Bioinformatics and CADD in other biopharmaceutical projects , provided that a collaborations with experimental groups exist . Topics of my interest include structural and functional effects of single point mutations in human proteins disease mutations or pathogen proteins resistances as well as ligand protein interactions , within the scope of computer aided drug design or chemical genetics projects . Specialties : Computer aided drug design , structural bioinformatics , computational chemistry , project and team management . Technologies :",
"Drug Discovery Scientist . . An interdisciplinary scientist with a strong background in Computational Medicinal chemistry , Structural bioinformatics , Pharmacogenomics . SKILLS : Structure Based Drug Design Multi Scale Modeling Simulation of Biological Macromolecules Machine Learning and Artificial Intelligence in Drug Discovery Pharmacogenomics and Adverse Drug Reaction , Drug s Mechanisms of Action and Resistance Programming languages : Pascal , C , Python Tools : DEEPCHEM , AUTODOCKVINA , VMD , NAMD , GROMACS , AMBER , GAUSSIAN , MODELLER , CLUSTALW2 , BEDTOOLS , SAMTOOLS , GALAXY , BIOCONDUCTOR , PHARMCAT , SMART LINK , TYPESTREAM KEY ACTIVITIES : Leading a study on pharmacogenomics and adverse drug reaction in the Vietnamese population including SCARs and DILI Investigating the interactions of Spike protein on coronavirus with antibodies and nanobodies using molecular dynamics simulation Designing a universal vaccine based on hemagglutinin epitope regions highly conserved among Influenza A virus clades Identifying and optimizing hundreds of lead compounds , building the Vietherb database which has nearly 10.9k metabolites for drug development Leading the Computational Biology Center and teaching Computer Aided Drug Design and Bioinformatics , Supervising postdocs , 4 Ph.D. and 10 MSc students . ACHIEVEMENTS : Published 90 scientific papers and two databases https : vietherb.com.vn https : genome.vinbigdata.org about http : cbc.bio.hcmiu.edu.vn people https : scholar.google.com citations user kYhcPQ8AAAAJ hl en PROFESSIONAL ACTIVITIES Associate Editor for BMC Human Genomics , Current Pharmaceutical Design , MedPhaRes , Editorial Board Member of Nature Pharmacogenomics Reviewer of Nature , BMC Bioinformatics , Journal of Biological Systems , Journal of Computer Aided Molecular Design , Medicinal Chemistry Research , Journal of Chemical Physics Conference Co Chair of Genomic Medicine 2015 , 2017 , 2019 Project Joint Coordinator of gLINK , Erasmus Mundus Action II http : www.glink edu.eu Scientific Committee member of GIW2013 and GIW2014 . Technologies :",
"Principal Investigator . . Being a molecular biologist by training , I am biased to see recurring patterns and potential pathways in a given set of data . That is why I believe a sharp mind per se is not enough to be successful in science . It takes a lot of hard work , alertness and luck in addition to brains to get there . In other words , blood , sweat and tears . Well , that is a challenge most of us are willing to take , otherwise , what would we be doing here I think I would not be so wrong if I ve said we all have curious minds and we love to wonder why . I needed to satisfy the hunger of my own curious mind it was almost inevitable for me to end up in science . Following this desire , I did my undergraduate studies on Molecular Biology and Genetics and continued with graduate studies on Molecular biology Genetics Biotechnology . During my studies , I was always thrilled to work in a variety of different fields from antibiotic production in bacteria to forensic medicine . I believe a well trained mind is only achieved by constant challenge . That was the point I kept in my mind especially during my M.Sc . studies , while I was working on human genetics , giving seminars about structural biology software , and working in a private clinic at the same time . When I started my PhD at the ETH Zurich , I of course did not have anything less in mind . Currently , I am a Principal Investigator at University of Helsinki and Wihuri Research Institute . My current research interests are focused on i studying the role VEGFRs and their interactions in regulating organ specific vascular responses and ii developing therapeutic targeting strategies against obesity and diabetes induced adipose tissue inflammation and vascular leakage . Technologies :",small molecules;interaction;screening
"Senior Scientist , Computational Biology and Machine Learning . . . Technologies :",
"Senior Scientist . iPSC derived immunotherapy . Highly motivated and creative molecular cell biologist with multidisciplinary knowledge . Have a strong problem solving skills and developing strategic solutions . Excellent interpersonal skills and really enjoy working in a team . 10 years of experience in molecular and cellular biology 7 years of Massively Parallel Signature Sequencing MPSS of non coding RNAs 5 years of non coding RNAs study in host Innate Immunity Cell culture of immune cells and stem cells , protein characterization , ELISA , etc . Small animal handling experience ; IV injection , perfusion , brain and spine tissue slicing and staining Over 10 years teaching and mentoring master students , interns and research assistant level scientists Demonstrated ability to adapting to new projects in cross functional laboratories Transfer accomplishments by presenting posters and talks at national and international conferences Computer analysis skills : Origin , Paravision , Amira and Illustrator Language : fluent in English and Mandarin Chinese . Technologies :",
"BIOVIA Scientific R D Development Manager , Biologics Modeling . . Experienced Science Research Specialist with a demonstrated history of working in academia . Skilled in Python , JavaScript , Life Sciences , Structural Bioinformatics , Scientific Visualization , and Molecular Biology . Doctor of Philosophy Ph.D. in Biophysics from Humboldt University of Berlin . . Technologies :",
"Computational Chemist Biologist . . Experienced professional with a demonstrated history of working in the pharmaceutical industries . Skilled in molecular dynamics , systems biology , agent based modeling , machine learning and AI , and computational chemistry biology .. Technologies :",
"Senior Staff Scientist . . Highly motivated Scientist with broad spectrum of skills and extensive experience in target discovery and validation in oncology and immune oncology . My most valued qualities are exceptional ability of problem solving , independent thinking and analytical skills , as well as outstanding leadership skills and audacity in making decisions . I have extensive experience in many molecular and cell biology techniques , as well as data integration for discovery of novel biology and mechanism of action of drug targets . I am currently looking for opportunities in meaningful , breakthrough innovative translational research to aid development of new disease treatments .. Technologies :",
"Senior Bioinformatics Scientist . . The field of my research focus on disease related bioinformatics Acute Myeloid Leukemia , Parkinson s Disease , Naegleria Fowleri amoeba . The research assistance of jobs include analysis RNA seq , computer server and be a lecturer of bioinformatics to promoting Ensembl personal browser in Yang Ming University for 2 years . 8 years of experience in learning bioinformatics , which including 4 years of experience with next generation sequencing data .. Technologies :",
"Non clinical study director . Research Project Lead for immunology programs . Manage a multi disciplinary team to deliver novel therapeutics to the oncology , neurodegenerative diseases , and virology pipeline . Design and oversee in vitro and in vivo validation and antibody screening , mechanism of action and biomarker development efforts for novel targets . Design and execute programs focused on large molecule , bi specific antibodies , antibody drug conjugates ADC and cellular therapeutic modalities . Establish and drive strategic external collaborations and manage CROs to facilitate preclinical development of candidate molecules . Oversee preparation of the GLP GMP regulatory submission documentations including patenting and pre IND applications to support clinical trials . . Result oriented professional with 7 years of scientific research experience in the fields of neuroscience , oncology , immunology , and infectious diseases and 3 years of professional managerial experience in a leading CRO . Seeking to build a career to utilize my skills that ensures personal and professional growth while being resourceful , innovative and flexible . Leader Researcher Philanthropist Social worker Achiever . Technologies :",antibodies;quality;screening
"Bioinformatician . . I am a graduate student from George Mason University holding a Master 's degree in Bioinformatics and Computational Biology . I have completed my Bachelor 's in Computer Science Engineering . During my engineering , I have done projects in Java and python which involves text processing . I have worked on a bioinformatics research project for 7 months , which involved web development and biological data analyses . In my Master 's , I have completed coursework in R and Perl programming . My master 's thesis involved studying FGFR2 kinase mutations to find differences between cancer and syndrome causing mutations . Currently , I am working as a Bioinformatician at Dekker Lab and working on HiC data , Django and Nextflow . I am looking for job opportunities in the areas of Bioinformatics and Computer Science . . Technologies :",
"Senior Research Scientist . mainly invole in planning and executing organic synthesis participate and give weekly update inputs in project meetings . . Primary activity in recent years included the design fragment structure based and synthesis of small molecule drug candidates towards determined target Key scientific contributor for several lead anticancer NCEs , which are in the early stage of development Knowledge of synthetic chemistry related to New modalities such as PROTACs and DECL etc . Established publication record in peer reviewed scientific journals . Technologies :",
Research Scientist . Structure based drug design . Structure determination of pharmaceutically relevant protein targets using X ray crystallography and cryo EM . Technologies : Xray;CryoEM,proteins;interaction;structure
Postdoc Scientist MedChem Targeted Protein Degradation . . Medicinal Chemist with a focus on targeted protein degradation . Former synthetic chem postdoc at Weizmann Institute of Science with Prof. London Organic Chemistry PhD at University of T bingen with Prof. Fleischer in the field of homogeneous transition metal catalysis .. Technologies :,molecular glues;developing
"Principal Software Developer . . Principal Software Developer working as part of an AGILE team within the CASM group at Welcome Sanger Institute . Developed CaVEMan substitution calling algorithm for NGS data . Specialties : Python , Perl , SQL , XML , C , Data Analysis Applications , New Sequencing Technologies , Bioinformatics , Database Design , Sequence Analysis , Git , Subversion , Linux , Agile . Technologies :",
"Research Investigator . Structure guided drug discovery utilizing X ray crystallography . . Experienced Researcher with a demonstrated history of working in the higher education institute . Skilled in Protein Biochemistry , Biotechnology , Cell Culture , Molecular biology , Microscopy . Hands on experience on most of the biophysical techniques , including x ray crystallography and cryo EM . Currently , utilizing x ray crystallography and cryo EM in the field of drug discovery . Published research articles in reputed journals . Strong research professional with a Ph . D focused in Protein biochemistry and structure biology from Institute Of Microbial Technology .. Technologies : Xray;CryoEM",proteins;small molecules;structure
"Postdoctoral Researcher . As a member of the Pharmaceutical Development Biologics department In Silico Team and in collaboration with the Biotherapeutics Discovery department in Ridgefield , I contribute to the design , optimisation and development of biologicals . I am involved in several aspects of R D of clinically relevant antibodies and apply regularly several sequence and structure based approaches . Besides actively participating to the developability assessment of internal BI candidates , I implemented the use of molecular dynamics simulations within the internal pipeline and developed models to drive the selection of the best candidates . . I am an experienced computational chemist and molecular modeler with strong expertise in molecular simulations , bioinformatics and drug design . I have an additional experimental background in spectroscopy and advanced optical techniques . Several international research experiences have influenced my ability to adapt to various groups and to work in a team oriented environment . I am deeply interested in developing tools for pharmaceutical research and in solving challenging problems in drug discovery . Presently , I am working as a Postdoctoral Researcher at Boehringer Ingelheim in the Pharmaceutical Development Biologics department . Here , I take actively part in all aspects of in silico antibody assessments and in the implementation of novel advanced tools for the internal pipeline . Specialties : . Molecular dynamics simulations and analysis of trajectories NAMD , GROMACS , VMD . Enhanced sampling techniques such as Umbrella Sampling , Free Energy Perturbation or Metadynamics . Quantum mechanical calculations such as DFT or ab initio MP2 Gaussian , ADF , Turbomole , Dalton , ORCA . Force field parametrization of small molecules ffTK , Antechamber , CGenFF . Homology modelling and structural biology . Bioinformatics BLAST , Clustal , Abysis . DNA and protein sequence analysis . Engineering and simulation of full length and multi specific antibodies . Molecular docking and Monte Carlo conformational search Autodock Vina , Macromodel . Molecular visualization and movie preparation VMD , MOE , Maestro , Blender . Scripting and data analysis Python , Bash , Tcl , SVL , Matlab . Main developer of MembraneMixer plugin VMD and ORCA interface for ffTK VMD . Machine Learning and classification models . High Performance Computing environments Blue Waters , TACC and Cloud Computing Azure . Technologies :",
"Principal Scientist . Molecular modelling Protein formulation and biophysics . I hold a M.Sc . in Biochemistry and a PhD in protein structure from the University of Copenhagen . For 20 years , I have worked with optimization of functional properties of industrial enzymes since 2011 in the Global Research Unit at Novo Nordisk A S with focus on functional and developability optimization of large proteins . I have experience with research project planning and execution from early discovery to development . I thrive in an innovative , flexible and dynamic working environment with cross disciplinary and international project teams .. Technologies :",proteins;characterization;formulation
Associate Computational Biologist . Neale Lab . . Technologies :,
"Associate Scientist Molecular Biology I Cell Biology I Metabolic diseases I Drug target Discovery . Research focus involves developing therapeutics to treat metabolic diseases . Contributing majorly in drug target discovery projects . Broad understanding of GPCR related targets . . Expert in monoclonal antibody , ADC , bispecific antibody , and small molecule screening , understanding drug mechanisms in pre clinical models in vitro and in vivo . Successful collaborations with multidisciplinary teams . Wide knowledge of in vitro , ex vivo and in vivo experiments . Expert for cell molecular biology experiments such as plasmid cloning , DNA transfection , qPCR , flow cytometry , CRISPR Cas9 , immunoassays , RNA scope , tissue spatial transcriptomics , histology other cell based assays . Experienced in determining effect of single molecule , combination or triple combination in mouse models of metabolic diseases . Well versed in scientific presentations , statistical analysis of research data , scientific interpretation and writing . Extensive 12 years life science experience of developing cancer and metabolic disease therapeutics . International research experience in preclinical screening of anti cancer drugs for major pharmaceutical clients . Experienced industry and academic research professional in the field of Biochemistry , Molecular Biology , Cell Biology , Oncology , Biotechnology and Pharmaceutical research . Expertise : New target discovery , Program leadership , Team management , Project management , Process development , Drug Development , Preclinical Research and Development . Expert in monoclonal antibody , antibody drug conjugate , bi specific antibody , and small molecule screening , understanding drug mechanisms in pre clinical models in vitro and in vivo . Leading successful collaborations with multidisciplinary teams , across departments , industries , and academic institutes . Experienced in cutting edge molecular biology and analytical methods , efficient science communicator and writer .. Technologies :",antibodies;membrane proteins;small molecules;screening
"Senior Research Scientist . . Self motivated senior molecular cell biologist with fifteen years of biologics and small molecule drug discovery experience from leading pharmaceutical companies Expertise in the design , generation and characterization of fit for purpose biologics drug molecules , including bispecific antibodies , Fc engineered antibodies and fusions with alternative scaffold proteins Extensive experience in Immuno Oncology by evaluation and optimization of Fc engineered antibodies for tumor immunotherapy Extensive expertise on drug target identification validation , HTS , assay development , mechanism of action studies Proven strong abilities to do innovative research , solve complex problems , and make critical scientific judgments with many prestigious publications Extensive experience in scientific presentation , project managements and research collaboration . Technologies :",antibodies;biologics;developing;engineering;screening
"Research Specialist III . Researcher structural TEM for biology and EM lab manager . Specialized in : Cryo TEM , negative staining and data processing . Automated data collection single particles and tomography . Protein , protein DNA and RNA complex structure determination . . Researcher in a structural TEM lab . Electron microscopy lab manager and electron microscopy and data processing intructor . Assessing new projects and collaborations , working with students as well as leading my own research projects . Specialties : biophysics , structural biology , transmission electron microscopy , cryo EM , negative staining , image data processing , single particles , 3D reconstruction of molecular complexes protein , protein DNA , tomography . Technologies : CryoEM",proteins;structure
"Senior Entomologist . Innovation Projects to Proof of Concept stage i.e. to identify , appraise and support emerging technologies in relation to insect control methods on a global scale . . I am a behavioural ecologist with interests ranging from analysis of individual behaviours to modelling population dynamics . Previous work has included describing mosquito host seeking behaviour using machine vision and machine learning , as well as individual based modelling of both natural and artificial systems , focusing on vector control interventions , for example bednet design . My work currently centres on innovation and product development with Rentokil Initial for the control of insect urban pest and disease vectors . Prior to mosquitoes I have worked with fish , beetle , aphid and parasitoid wasp species .. Technologies :",
"Director of Bioinformatics , Oncology . . Ph.D. in Computational Biology . Three times Illumina Value Award for driving tissue and liquid biopsy product dev and academia collaborations . 12 years experience in machine learning and bioinformatics . 10 years experience in developing clinical grade NGS tests in both NIPT and Oncology . Strong analytical and programming skills . Interested in building algorithms and predictive models to interpret large scale biological data . . Technologies :",
"PHD Student . Department for Structural Biochemistry AG Engel Research Topic : Assembly of eukaryotic ribosomes is centred around the four ribosomal RNAs rRNAs . The nascent ribosomal RNA precursor contains three of these rRNAs and is transcribed by the RNA polymerase Pol I machinery . In contrast to other polymerases , Pol I has evolved a minimal , but extremely specific and highly regulated set of transcription factors for the synthesis of its sole target . Over the past years , structural analysis of Pol I and its transcription machinery has revealed stunning differences but also striking similarities with Pol II and Pol III . We used X ray crystallography to solve the first 3D structure of the entire 14 subunit , 590 kDa Pol I enzyme from yeast at atomic resolution Engel et al . , Nature 2013 . Combining results from crystallography with recent advances in cryo electron microscopy cryo EM now allows the application of an integrated structural biology hybrid approach for the analysis of transient , regulatory complexes . This enabled us to study transcription initiation intermediates Engel et al . , Nature Communications 2016 , elongation complexes Neyer et al . , Nature 2016 and multi factor DNA RNA protein assemblies active in transcription Engel et al . , Cell 2017 . Continuing and expanding the structural analysis of Pol I and its transcription machinery with this integrated approach hold the promise to generate textbook knowledge about the critical process of rRNA synthesis common to all eukaryotic cells . In combination with biochemical analysis Lisica , Engel et al , PNAS 2016 and Engel , Meth . Mol . Biol . 2016 we pursue a hypothesis driven experimental approach . . As part of the group of Prof. Dr. Engel at the Department for Structural Biochemistry within the Biochemistry Center Regensburg at the University of Regensburg , I am working on my PhD thesis in the field of structural biochemistry using cryoEM and various other techniques . I have received my Master of Science and Bachelor of Science in biology from the University of Regensburg , Germany . My master thesis Analysis of archaella preparations from selected Pyrococcus furiosus strains was done in archaeal structural microbiology at the Centre for Electron Microscopy at the University of Regensburg in the group of Prof. Dr. R. Rachel . My bachelor thesis Heterologous expression of the transcription elongation factors Spt4 and Spt5 from Pyrococcus furiosus was done in archaeal molecular microbiology in the group of PD Dr. W. Hausner at the chair of Prof. Dr. M. Thomm .. Technologies : Xray;CryoEM",proteins;expression;structure
"Scientist TME , Clara Drug Discovery . . Data scientist , Computational Structural Biologist , Big Data enthusiast : Working at the interphase of GPCR Structural biology , Chemoinformatics , Drug discovery , Machine Learning , and High performance Cloud computing . Technologies :",
"Science Department Faculty Member . Teaches approximately one hundred and fifteen sophomores in high school level chemistry . Communicates with parents , counselors , and other members of the faculty on strategies to best meet the learning goals for each student . Prepares lesson plans to meet current NGSS teaching standards . Participates in various professional learning communities and offers input and feedback regarding the school s mission . . I am highly interested in the intersection of computer science , statistics , and their applications to human health . In recent years , the cost of genetic sequencing has reached a new low , allowing researchers to utilize far more data so that the study of complex biological models may be possible . It is quickly becoming an exciting field full of possibilities . I look forward to an exciting future in teaching , researching , and working in the medical field . During my time at Cornell , I have focused my studies using a broad range of classes , from biology laboratory courses to computer science and math courses . I 'd like to put those studies to good use , helping to advance biological research and our understanding of human health . Please contact me at : ajf256 cornell.edu . Technologies :",
Lab Manager . . . Technologies :,
"Graduate Student . . I 've worked in structural biology for five years . We focus on single particle analysis of ENaC , a highly flexible membrane protein . I 've developed functional assays , cloned new constructs , developed our purification workflow , and performed electrophysiological studies of the channel . Additionally , I built and maintained all of our lab 's computational infrastructure . I am our lab 's system administrator , and have helped set up several other lab 's computation resources . I also wrote and developed a variety of tools that are used daily in multiple labs at OHSU , including Appia , a web based chromatography processing package .. Technologies :",membrane proteins;structure
"Director , Bioinformatics Biostatistics Core . . . Technologies :",
"Vertex Fellow . . Experienced researcher with a demonstrated history of working in the biotechnology industry . Skilled in Mammalian Cell Culture , Molecular Biology , Tissue Engineering , Matlab , and Python . Strong research professional with a Doctor of Philosophy Ph.D. focused in Biomedical Engineering from Harvard University . . Technologies :",
"Senior Research Associate . . Currently working at R D Department and mainly involved in : High Throughput Screening of enzymes on different properties purification , stability , activity HTS friendly antibody detection , purification and quantitation using ELISA and analytical techniques Assay Development Downscaling application conditions to laboratory scale and setup reliable predictable assays FPLC HPLC related work i.e. enzyme purification , quantification , product analysis , sugar polymer analysis Molecular Biology gene cloning , expression , different PCR techniques . Technologies :",antibodies;screening;stability
"Scientist . . I am currently a Scientist on the Discovery Team at Metagenomi . I completed my PhD in Chemistry and Chemical Biology at UCSF where I studied ribosome targeting antibiotics and resistance through ribosome modification . I elucidated how mutants of the rRNA modifying enzyme Cfr obtained through directed evolution cause increased resistance . I performed structural analysis of stalled ribosome complexes obtained by cryo EM to determine the molecular basis of translation inhibition by oxazolidinone antibiotics . I received my BS in Chemistry concentrating in Biochemistry from UNC Chapel Hill . For my honors thesis , I performed stereoselective synthesis of fluorinated tryptophan analogs to interrogate the binding and recognition of methylated lysine by the HP1 chromodomain through unnatural amino acid mutagenesis . Publications 1 . Tsai K , Stojkovi V , John Lee D , Young ID , Szal T , Vazquez Laslop N , Mankin AS , Fraser JS , Fujimori DG . 2022 . Structural basis for context specific inhibition of translation by oxazolidinone antibiotics . Nat Struct Mol Biol . doi:10.1038 s41594 022 00723 9 Authors contributed equally 2 . Tsai K , Stojkovi V , Noda Garcia L , Young ID , Myasnikov AG , Kleinman J , Palla A , Floor SN , Frost A , Fraser JS , Tawfik DS , Fujimori DG . 2021 . Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance . eLife . doi:10.7554 eLife.70017 3 . Stojkovi V , Ulate MF , Hidalgo Villeda F , Aguilar E , Monge Cascante C , Pizarro Guajardo M , Tsai K , Tzoc E , Camorlinga M , Paredes Sabja D , Quesada G mez C , Fujimori DG , Rodr guez C. 2019 . cfr B , cfr C , and a New cfr Like Gene , cfr E , in Clostridium difficile Strains Recovered across Latin America . Antimicrob Agents Chemother 64 . doi:10.1128 AAC.01074 19 4 . Mavor D , Tsai MK , Kampmann M , Fraser JS . 2018 . Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance . Biol Open 7 . doi:10.1242 bio.036103 5 . Chang JC , Findley DJ , Cunningham CM , Tsai MK . 2014 . Considerations for Effective Lidar Deployment by Transportation Agencies . Transp Res Rec 2440:1 8 . doi:10.3141 2440 01 . Technologies : CryoEM",proteins;interaction;structure
"Staff Computational Systems Biologist . Responsibilities include research , development , and productization of algorithms and methods that operate over biological networks and genomic data , driving innovations for Ingenuity Pathway Analysis IPA and Variant Analysis VA products . In particular , leading design and implementation of statistical algorithms and other features available in VA e.g. statistical association filters , pedigree inference , ancestry prediction , druggable pathways , as well as developing and prototyping causal analysis algorithms for IPA e.g. Pathway Activity Analysis . IPA is a web based application to interpret biological data that has been broadly adopted in the life science research community . VA is a widely used tool to identify causal variants in human sequencing data . . Experienced scientist with expertise developing advanced computational algorithms in biology , chemistry , and physics . Proven ability to provide scientific and technical leadership , and deliver innovative solutions and product features . Experienced working in interdisciplinary and cross functional settings in collaboration with domain scientists and software engineering teams . Recent projects involve biological interpretation of genomic and gene expression data , network algorithms , ontology derived pathway models , and statistical genetics . Interests : predictive modeling of biological systems , gene regulatory networks , statistical and biological physics , machine learning , data analysis and visualization , computer science and software design patterns . Skilled programmer with extensive software development experience in Python and C including scientific computing using Numpy , Scipy , Pandas , scikit learn , and Matplotlib libraries .. Technologies :",
Scientist Electron Microscopy . . Structure biologist by training from membrane protein biochemistry to hands on single particle cryo EM . Now collecting experience of electron microscopy in a GMP environment .. Technologies : CryoEM,membrane proteins;structure
"Lead R D Scientist . Key responsibilities : . Developing and executing a research program technology program independently to support a project goal . Functional representation of Immunology Cell biology department ICB in four technical global project Ophthalmology Gene therapy , Oncology and Infectious diseases teams in antibody based drug discovery and development until Ph0 . Plan , design and supervise a research program technology program or experimental strategies within the context of department and or project goal in Ophthalmology , Gene therapy , Oncology and Infectious diseases . Key achievements : . Led an establishment of a tandem team concept between ICB and Lead ID departments to streamline collaboration and work between the departments . Wrote and presented target proposal for a new antibody based drug Immunology . Provided the key data for the patent filing Oncology . Led automation of cell based assays within the Immunology Cell biology department . Led collaboration with an academic partner University of Oslo . Three talks : Ab engineering for PK improvement underestimated indirect outcomes at Large Molecule DMPK exchange meeting Effector function meeting ; New insights into antibody hinge Fc functionality at Effector function meeting . Four scientific publications in high impact journals such as Science Translation Medicine or Journal of Experimental Medicine . Scientist by training with multidisciplinary experience and thriving in immunology and antibody based drug discovery fields with 15 publications in prestigious international peer reviewed journals as main author or co author . High sense of responsibility with an agile working culture . Has led research projects in academia and industry with collaboration with multiple teams across the globe Karolinska Institutet , Harvard Medical School and Roche Diagnostics .. Technologies :",antibodies;developing;engineering
"Associate Professor . . I currently hold a Royal Society University Research Fellowship at the University of Warwick where I lead a research group in modelling and simulation applied to a range of challenges in pharmaceutical science , biomedicince and bio nanomaterials science . I have a strong track record in collaborative research , working closely with both academic scientists from a range of disciplines and industrial partners . Keywords : modelling and simulation , computational chemistry , biomolecular simulation , molecular dynamics , multi scale modelling , data analysis , high performance computing , computational biophysics , computer aided design , drug design and discovery , drug delivery . Publications : http : www.researcherid.com rid C 2066 2009 Website : www.warwick.ac.uk go notmangroup . Technologies :",
"Scientist Protein Sciences . . My interest lies in connecting the dots between protein structure and it s function . Protein biochemist and biophysicist with 9 years of experience on working with membrane proteins folding using detergents , lipid vesicles , bicelles and nanodiscs and their characterization using Circular Dichroism and fluorescence spectroscopy , NanoDSF , MST , ITC , DSC , DLS , SEC MALS Currently working on large membrane protein complexes and understanding their structure using Cryo EM . Trained to prepare grids and do negative staining and visualizing the grids on Talos L120C .. Technologies : CryoEM;ITC;SLS DLS;DSC;MST;DSF;CD",membrane proteins;proteins;characterization;interaction;stability;structure
"Assistant Professor . Research focus : Transcriptional regulation Non coding RNAs in brain AI in disease prediction . Dr. Dong received a Ph.D. degree in Bioinformatics in the University of Bergen and a Postdoctoral fellowship in Bioinformatics and Integrative Biology at University of Massachusetts Medical School . Dr. Dong is now an Assistant Professor of Neurology in Harvard Medical School and the founding Director of Genomics and Bioinformatics Hub https : bioinformatics.bwh.harvard.edu in the Harvard affiliated Brigham and Women 's Hospital in Boston , leading the Bioinformatics team working on neurodegenerative diseases such as Parkinson 's disease , Alzheimer 's disease , Huntington 's disease , etc . He is interested in developing and applying computational methods to understand the transcriptional regulation of the human genome , by integrating genomic , transcriptomic , epigenetic , and clinical data from both healthy subjects and patients with neurological diseases . Dr. Dong has 40 publications with 19000 citations and an H index of 23 . He has made several web based tools to facilitate the research of long range gene regulation . He is familiar with various NGS data analysis , incl . ChIPseq , RNAseq , RNA PET , CAGE , and WGS data . He was an active member of the ENCODE consortium . He is particularly interested in the non coding RNAs miRNA , eRNA , circRNA , etc . in the brain . Dr. Dong is recently funded by the American Parkinson Disease Association APDA , NIH R01 , U01 , R41 , and Aligning Science Across Parkinson 's ASAP . See his website for more details : http : sterding.github.io Specialties : Knowledge of gene regulation , neurodegenerative diseases , comparative genomics , NGS lib design , and small RNA ; Skills in algorithm development , data integration , visualization , parallel computing , statistics , and various NGS data analysis .. Technologies :",
. . I am an aspiring medicinal chemist chemical biologist developping PROTACs for epigenetic proteins .. Technologies :,molecular glues;developing;interaction
"Director of Bioinformatics , iHope Genetic Health . Thrilled to be part of a dynamic team paving the way for equitable access to clinical whole genome sequencing , research and treatment across the globe through the iHope Genetic Health Program . . Vani Rajan brings a decade of bioinformatics experience in the clinical diagnostic setting . Her passion is in developing efficient , large scale processes to enable individuals access to their own genetic information . Prior to joining Genetic Alliance , she was a Manager of Bioinformatics at Illumina Inc , where she managed the bioinformatics operations supporting the service lab s clinical whole genome sequencing for proactive health and patients with rare and undiagnosed diseases . Additionally , she has pushed continuous process and analytical improvements to the laboratory and bioinformatics pipeline respectively through software efficiencies . Vani graduated from Georgia Tech in 2011 , with a Master of Bioinformatics , and Carnegie Mellon University in 2010 , with a Bachelor of Science in Electrical and Computer Engineering and a Bachelor of Science in Biomedical Engineering .. Technologies :",
"Masters Researcher . Working at the intersection of computer vision and psychology with Karttikeya Mangalam under Professor Jitendra Malik . . M.S. EECS student with deep interests in artificial intelligence , computer science , and mathematics . Motivated by theory and the scientific method , currently interested in replicating human behaviors in computer vision systems .. Technologies :",
"Head of Quantitative Research . . I am a computational physicist and quantitative researcher , with expertise in data science , machine learning , and applying machine learning to exciting problems in fundamental science and mathematical finance hedge fund quantitative research and decentralised finance . I use and develop advanced machine learning techniques , including deep neural networks and Bayesian inference . I have expertise in computer programming , particularly C and Python , advanced mathematics , theoretical physics , computational biology , quantitative finance , statistics , and applied data science . I am currently applying mathematical and quantitative finance strategies and models to the DeFi space , building up experience in blockchain , smart contracts , and fixed income derivatives strategies in cryptocurrency markets .. Technologies :",
"Director and Head of Clinical Pharmacology . . It 's fair to describe my research background as eclectic . During my bachelor 's degree , I studied Astrophysics at Bishop 's University . During this time , I developed computer models of low mass close binary star systems . I completed my bachelors degree in Physics , Biology and Mathematics in 2002 . I completed my PhD. in cardiovascular physiology in 2007 where I developed a novel and ambitious computer model of electronic interactions between cardiac myocytes and fibroblasts . During my post doctoral work , I studied the effect of hypoxia upon myocardial excitation contraction coupling . For this work , I earned a post doctoral fellowship from the American Heart Association ; the first such award to be won in the state of Hawaii in over a decade . I began my industry career as a Principal Pharmacometrics Scientist at the Novartis Institute for Biomedical Research in Cambridge , MA . I divided my time between the Computer Aided Drug Design CADD and engineering clusters where I developed computer models of drug interactions . As Associate Director of Pharmacometrics at Biogen , where I was the clinical pharmacology lead on multiple platform and pipeline projects in the area of neurodegenerative diseases . I provide quantitative clinical pharmacology and modeling support for putative treatments for both MS , spinal muscular atrophy , and Alzheimer 's disease . I have just accepted a position as Director and head of Clinical Pharmacology at Dyne Therapeutics where I will plan and implement the clinical development of the FORCE platform for Muscular Dystrophy . In this role , I will be responsible for understanding and predicting the therapeutic dose levels for this unique modality .. Technologies :",
PHD Student . . Student and young researcher in Copenhagen . Interested in protein structure and now learning cryo EM .. Technologies : CryoEM,proteins;structure
Staff Scientist . . . Technologies :,
"Senior Bioinformatics Software Engineer II . . My research is focused on providing high level scientific expertise to create pipeline tools that enable next generation sequencing analysis . This includes whole genome , exome , bulk RNA , small RNA , ATACseq , scRNASeq and epigenomics NGS datasets using internal and external cloud computing resources and high performance computing . . Technologies :",
"UK Dementia Research Insitute Emerging Leader . . Computer languages : Proficient in Perl , Bash scripts in Linux Unix environment Working knowledge of Python , C C , HTML , PBS scripts Statistical knowledge : Proficient in hypothesis testing continuous and categorical variables , ANOVA , logistic and linear regression , power calculations , non parametric hypothesis testing , association analysis , set based analysis , polygenic score analysis , whole genome association analysis , permutation tests , Principal Component Analysis PCA Statistical packages : SPSS , proficient in R Bioinformatics skills : Proven expertise in analysing DNA and RNA seq data SE PE ; directional and non directional Proven expertise in analysing gene expression data microarrays and RNA seq , including pathway analysis , e.g. GO InterPro categories analysis Proven expertise in handling and analysis of very large datasets Extensive expertise in mutation analysis : evolutionary conservation , nucleotide substitution rates , analysis of repetitive elements and micro lesions Experience in EM algorithm based clustering and tree based search algorithms Comprehensive knowledge of biological databases e.g. NCBI , UCSC and commonly used bioinformatics software Extensive experience in CNV analysis , including novel methodology Extensive experience in development of applications , including design of algorithms and implementation Extensive experience in support and maintenance of an array of Linux and Unix based multi processor servers software applications and hardware Lab based skills : Extensive experience in DNA handling , amplification and variant detection . Technologies :",
"Bioinformatics Scientist . . Neuroscientist , Bioinformatician , and Cloud Solutions Architect .. Technologies :",
"Senior QC Microbiologist . . I am currently working a six month contract at Amgen as a Microbiologist in the QC department , where I am gaining a high level of practical experience and skills . I hope to become part of a successful company with an aim to working in a scientific environment . I am an outgoing and competent person who works well with people . I have been employed in part time positions during my 4 years in college while maintaining a high level of academic work . I have completed an Honors Degree in Bio analytical Science in 2010 , through Tallaght Institute of Technology , following my degree I took part in the Innopharma lab training programme to further my knowledge and remain active within the pharmaceutical Science environment while I sought employment . Specialties : Medical Industrial microbiology : Culturing techniques , Fermentation , sterilisation etc . Immunodiagnostics : Immunology , Cell lines , polyconal antibody production , ab ag interactions , Immunoassays e. g. ELISA . Molecular diagnostics : DNA cloning Fingerprinting PCR methods , hybridisation techniques e. g Dot blots . Bio analytical techniques : Automated analysis , Chromatography e. g. HPLC , GC MS , CZE , NMR etc . Protein Bio chemistry : Separation of proteins Gel electrophoresis e. g. SDS page . . Technologies : NMR",antibodies;proteins;interaction
"Principal Bioinformatics Scientist . Genomics and Population Genomics Sequencing reference genomes and resequencing complete genomes of multiple individuals to identify , characterize and ultimately understand the DNA variation that contributes to phenotypes . Metagenomics and NGS Diagnostics Analysis of metagenomic data from high throughput sequencing for research and diagnostic applications including the design and validation of NGS diagnostics . Building and managing bioinformatics workflows for use in regulatory contexts . Adjunct Teaching I teach and develop CS department courses : Python programming with an emphasis on data science , Data structures and algorithms in Python , and Bioinformatics . These courses are targeted at non majors with the idea that computer science is the new math . . Computer scientist and bioinformatician with extensive experience in academia and the biotech industry . Throughout my career I 've enjoyed collaborative interdisciplinary projects at the intersections of computer science , statistics , and biology . I have specialized in the analysis of data derived from advanced sequencing technologies . I have authored 50 publications with over 6000 citations . As an adjunct , I enjoy developing and teaching interdisciplinary computer science courses accessible to non majors with the pretext that computer science is the new math .. Technologies :",
"Chief Scientific Officer . Heading the R D efforts to develop new services . Overseeing assay development , refinement and extensions . Supporting marketing and business efforts . Supporting customer projects and interactions . Heading collaborations and in vitro safety developments . . R D in diabetes and obesity biology , cancer biology , lipid metabolism , cell signaling , and more . Peptide and small molecule drug discovery , target ID and validation . Functional cell assays and biomarkers . In vitro safety assays . New Approach Methods in Toxicology . Drug target safety assessment . GPCR functional selectivity . Cell and molecular biology . Protein Sciences . Biologics production . Line management . Project management . Supervisor . Lab manager . Lab safety officer . Technologies :",
Senior Computational Chemist . Working on Oxford Drug Design 's novel antibacterial programme . . . Technologies :,
Senior Machine Learning Scientist . . I am a computational biologist and machine learning researcher working at Freenome in San Francisco . We are actively developing a blood test to detect early stage cancer .. Technologies :,
"Assistant Adjunct Professor Medicinal Chemist . As a member of the Institute for Neurodegenerative Diseases Drug Discovery group , I am working to advance our small molecule portfolio toward clinical trials . In partnership with other adjunct faculty at the Institute , including computational chemists , neurobiologists , cell biologists , analytical chemists and pharmacologists , I design and synthesize novel CNS drug candidates using cryo EM models , cellular and in vivo assay SAR data , ADME pharmacokinetics , and calculated drug like properties . A significant part of my role is to lead , train and mentor junior co workers in the chemistry lab , and I work closely with chemists at contract research organizations for analogs or small library synthesis and facilitate their progress by transferring synthetic routes and procedures from our laboratory at UCSF to the CRO . In addition to my contributions to medicinal chemistry , I initiate and contribute to the development of biological assays to support projects specific needs . . . Technologies : CryoEM",small molecules;developing;structure
"Principal Scientist II . . Career Goal : Drug design discovery positions in the biotech and pharma fields where I can utilize my expertise in cryo electron micoscopy and structural biology . Career Path : While obtaining my BS in Molecular and Biological Sciences at UC Davis I performed undergraduate research in professor Neil Hunters lab and in Professor Marc Facciotti 's lab for a total of two years . Additionally I was a member of the UC Davis international Genetically Engineered Machine iGEM team in which we placed as finalists . After my undergraduate education I explored the biotech industry in order to experience research in the private sector and explore new fields of science . I received a job at Amunix Operating Inc. as a Research Associate right out of college and worked there for two years . At Amunix I worked on large scale protein purification , formulation , and protein chemical conjugation . Gradually I also became interested in structural biology and decided to explore it further by working an additional part time job in professor Ted Jardetzky 's lab at Stanford studying x ray crystallography . After working both jobs for a time I decided to gain a PhD to gain greater career opportunities in industry and to learn the field of structural biology . Shortly after starting my PhD in Chemistry and Biochemistry at UCSD I found a great interest in cryo electron microscopy cryo EM and joined professor Andres Leschziner 's lab . After just four and a half years in my PhD I am now publishing my manuscript https : www.biorxiv.org content 10.1101 2020.01.06.895367v1 . My work includes the solution of a high resolution structure of the Parkinson 's Disease associated protein LRRK2 and collaborative biochemical and cellular work on the protein 's interaction with microtubule filaments with the Reck Peterson , Villa , and Knapp labs . I currently plan to return to industry in a position where my 4 years of single particle cryo EM and structural expertise is utilized for drug discovery and design efforts . . Technologies : Xray;CryoEM",proteins;small molecules;interaction;structure
"Chief Technology Officer , Automated Science . . Scientific Technologies is a new kind of technology enterprise . Its mission is to create the radically different , science based technologies that we urgently need to address the greatest challenges of our times . One of the core foundations of the firm is Automated Science as an approach for transforming how science is done and what science is possible . As Chief Technology Officer Automated Science , I lead the strategic and technological development of our pipeline for automated reasoning and mechanistic model construction , parametrisation and empirical evaluation . This pipeline will enable the Automated Science needed to deliver radical impact at global scale in areas ranging from energy , food , climate mitigation to the intersection of financial markets and putting capital to radical purpose .. Technologies :",
"Principal Scientist . . Business Administration : HD1 Foundation at Copenhagen Business School , CBS HD2 Specialization in Management Accounting amp ; Process Management at Copenhagen Business School , CBS Balanced Scorecard , Strategy Maps and Strategic Management Kaplan amp ; Norton Strategy Project in The Danish Maritime Safety Administration Farvandsv senet Health Sciences , Immunology and Biochemistry : Antigen Presentation and Protective Immunity Antibody Generation , Screening and Application Major Histocompatibility Class I , MHC I , Tapasin and Calreticulin Molecular Biology , Cloning Protein Chemistry , Protein Purification and Functional Characterization Immunochemistry Assay Development ELISA , AlphaScreen , SPA , FlashPlate , Surface Plasmon Resonance X Ray Protein Crystallography IT Development : Microsoft .NET Programming , C , MS Visual Studio 2005 2010 SharePoint 2007 , 2010 and ASP.NET Java Programming MySQL , MSSQL Database Structure Development , Implementation and Maintainance XML , SOAP Specialties : Business Administration : Strategy Development and Management Scientific Research : Human Immune System IT Development : Microsoft .NET , MSSQL and SharePoint . Technologies : Xray;SPR;ALPHA SCREEN",antibodies;peptides;characterization;interaction;screening
"Senior Scientist . Built semi mechanistic SARs CoV 2 viral dynamic model contributing towards the FDA EUA approval of EVUSHELD mAb Developed Technical reports for submission to the regulatory agencies FDA , MHRA , EMA , TGA . . Trained in computational immunology with expertise in systems modeling approaches . I graduated with a Ph.D. in Translational Biology , Medicine , and Health with an expertise in computational modeling of infectious diseases . I have a background in Biomedical Engineering . During my master 's , I worked towards an advanced certificate program in Bioinformatics . I have a keen interest in the field of applied systems modeling , computational biology , healthcare data analytics , and bioinformatics . My thesis work involved building ordinary differential based mathematical models along with a data analytics pipeline for modeling the host immune responses against infectious diseases . I am currently employed at AstraZeneca Pharmaceuticals as a Systems Modeler within the Sytems Medicine in the Clinical Pharmacology and Quantitative Pharmacology department . My recent work at AZ involves building semi mechanistic viral dynamic models which contributed towards the EUA of the mAb against COVID19 .. Technologies :",
Research Team Lead . Promoted to Team Leader at BioAscent . Leading a team of chemists in the design and synthesis of target molecules to meet client requirements . I am currently a Team Leader Medicinal Chemistry at BioAscent . My personal experience is within the field of synthetic organic chemistry and its application to drug discovery . This includes modern techniques such as Fragment Based Drug Discovery and Targeted Protein Degradation . Technologies :,molecular glues;small molecules;screening
"Principal Scientist , CVM Discovery . Multi OMICs data integration , single cell RNA Seq and spatial transcriptomics . . Technologies :",
"Senior Manager , Scientific Research . . Carri Lyn Mead earned her Bachelor of Science degree from the University of Waterloo , Ontario , Canada and her doctorate in Genetics from the University of British Columbia , Canada , focusing on molecular interactions between genes and proteins implicated in psychiatric disorders . In between her undergraduate and doctoral degrees , Carri Lyn pursued a computer consulting career as an application developer and IT specialist with IBM . In 2003 , after realizing that she missed working in the scientific community , Carri Lyn chose to go back to school for her graduate degree . After completing her doctoral research Carri Lyn chose to seek out a position at Illumina that would enable her to capitalize on her computational and business training while following her passion for science within a company that is transforming genomics and how it is being applied to the clinic . While at Illumina , Carri Lyn has worked as a Scientific Liaison within Scientific Affairs , as a Whole Genome Interpretation Data Scientist in the Clinical Services Laboratory , as a Software Product Owner for the foundational design of Illumina 's Variant Interpreter , and within the Core Product Management Group where she focuses on evaluating contextualizing new and emerging technologies .. Technologies :",
"Senior Scientist . . Supporting the research on new biological entities with the bioanalysis of pharmacokinetics studies Protein analytics on diverse aspects using ligand binding assays and mass spectrometry Doctorate in Proteomics and Bioanalytics More than eight years professional experience in the pharmaceutical industry Good team spirit , analytical mindset , accurate and well organized way of working , reliability , open minded personality , solution oriented methodology . Technologies :",
"Senior Scientist . Front end Innovation , product development , biologics and haemostatic medical devices . . Innovative and curious protein chemist MSc . , PhD. with R D experience 11 years in industry and academia . Motivated by making a difference against disease and discovering new unique medicines . Experienced with pre clinical discovery , HTP expression , purification screening SPR of therapeutic antibody repertoires and leading cross organizational project discovery teams . Hands on experience with the latest nano and fluorescence based methods for running HTP MTP drug screening campaigns . Educated with project management research management courses . Experienced from biotech and pharma industry with all phases of preclinical drug discovery . From ideations with partners to project scoping , discovery and transfer to development . Research areas incl . , Therapeutic antibodies , preclinical discovery , protein engineering and HTP characterization GPCR s and mol . pharm . investigation of new ligands within nutrient sensing metabolism . Enzymes , surface mechanism regulation and new lead application research projects . Peptides , receptor and membrane associating peptides , regulation and function . Strong networker and communicator with several patents high impact publication list . Extensive experience working in a Global environment , with interdisciplinary and cross organisational projects and external collaborators . Specialties : Protein Chemistry Biochemistry Biophysics Molecular Pharmacology Protein Design and Engineering Cancer Immunology GPCRs TNFRs ILRs Synaptic proteins Enzymes Antibodies SPR Fluorescence Confocal and Electron Microscopy Assay Development Cell signalling assays HTRF assays Endocytosis Lipids and membranes . Technologies : SPR",antibodies;enzymes;membrane proteins;small molecules;characterization;engineering;interaction;screening
"Director . . Academic with expertise in computational social science , data science and complex systems . Research active in social networks , the Web environmental science .. Technologies :",
"Senior Director Distinguished Scientist . Experienced manager , currently leading a department of 30 drug discovery scientists Member of leadership teams driving portfolio decisions Strong foundational understanding across diverse therapeutic areas Cancer Immunology , Immunology , Oncology , Infectious Disease , Ophthalmology , Neuroscience . Experienced scientist and leader in the field of drug discovery across multiple drug modalities including protein therapeutics antibodies and cytokines , mRNA , anti sense oligonucleotides ASO and RNAi . I also have experience in different delivery technologies including antibody conjugates and lipid nanoparticles . I have moved several candidate molecules from discovery through to development as project team lead . I am currently leading a drug discovery department that is focused on discovery of protein therapeutics , gene therapy AAV and mRNA , ASO RNAi and cell therapy .. Technologies :",antibodies;biologics;nucleic acids;proteins;developing
"Senior Scientist , Drug Product Development . . Expert in product development CMC of lipid based formulations Focus : liposomes , small molecules , siRNA . Experience in GMP production of sterile dosage forms . Writer of documentation used for filing IMPD IND ANDA . Proficient in applying Quality by Design principles in development of complex injectables familiar with Design of Experiments DoE . Experience in stability studies of viral vaccines . Practical knowledge in Continuous Improvement Lean Green Belt certified . Excellent scientific writing presentation skills . Passionate about training coaching others , learning knowledge sharing . Pro active , analytical , structured , disciplined , accurate , collaborative , creative , driver of change . Technologies :",carriers;formulation;stability
Postdoctoral Researcher . Cryo EM Single Particle Analysis ; RNA Polymerase . . Technologies : CryoEM,proteins;structure
"Post doctoral research fellow . Structural , biochemical and biophysical characterization of topoisomerase DNA complexes . Chercheuse dynamique et motiv e , j ai d velopp des comp tences dans l expression , la purification et la caract risation biophysique et biochimique de complexes biologiques au sein de diff rents organismes procaryotes et eucaryotes . J ai galement appris deux techniques principales de biologie structurale : la cryo microscopie lectronique et la cristallographie aux RX . Ces techniques m ont permis d aborder des sujets scientifiques une chelle mol culaire qui est importante dans le d veloppement de mol cules th rapeutiques . Au travers de mes diff rents projets de recherche , j ai pris un r el plaisir dans le d veloppement et l optimisation de protocoles biochimiques biophysiques . Ma capacit d adaptation et mon esprit d quipe m ont permis de travailler sur plusieurs projets en parall le et en collaboration avec des quipes pluridisciplinaires et internationales . Forte de ces exp riences , je souhaiterais mettre profit et enrichir mes comp tences en biologie au travers de nouveaux projets innovants appliqu s au domaine de la sant . Dynamic and motivated researcher , I have acquired skills in the expression , purification and biophysical biochemical characterization of biological complexes in different living organisms prokaryotes and eukaryotes . I also got advanced training in two main techniques of structural biology : cryo electron microscopy and X ray crystallography . Thanks to these techniques , I have developed skills to analyze different scientific projects at a molecular scale , important in drug design area . Throughout my various research projects , I really enjoyed developing and optimizing biochemical biophysical experiments . My ability to adapt and my team spirit have allowed me to work on several projects in parallel and in collaboration with multidisciplinary and international teams . With these experiences , I would like to use and strengthen my skills in biology through new innovative projects applied to the health field .. Technologies : Xray;CryoEM",nucleic acids;proteins;characterization;structure
"BioInformatics Scientist . Software Engineering Medical Ontologies Natural language processing Dynamic visualization Engineering and implementation of variant interpretation tools for the Illumina Clinical services Lab . Continued development of existing front end applications for the analysis and interpretation of variants in Rare Undiagnosed diseases Design and development of a phenotype to gene tools which allows users to enter phenotype terms , provides suggested phenotypes from a dropdown of ontology based terms , includes synonyms of those terms in searches , queries OMIM for associated genes , disambiguates gene names and de synonymizes results . This gene lists produced can be uploaded and used to rank variants against closest fit to given phenotypes Development of backend variant annotation and filtering pipeline for reducing the number of variants that genomic councelors have to look at when analyzing cases Development of graphical user interface based system for monitoring sequencing progress and predicting analysis completion dates , for use by project managers running our labs Product owned , researched , designed and implemented the Basespace Variant Interpreter structural variant genome browser , using Java , ElasticSearch , Angular.js and HTML5 Canvas . The browser allows filtering of structural variants on the fly , display of annotations regarding those variants , and easy comparison of variant calls with coverage and b allele frequencies . Interim product owner for Basespace Variant Interpreter during its transition from a fledgling project through Concept and Feasibility stages . Implemented a web based genomic data copying system which has delivered over 70 T of data to customers with high reliability including automated check summing on external disks . . hiring I have 8 years now of BioInformatics software engineering , and 10 years experience as an MD in the UK . I 've been fortunate to be involved in some cutting edge work . I 'm currently working on indexing tools and genome visualization for multi omics and have designed and implemented PubMed gene disease relationship mining using Biobert , with overlying graph database APIs for use in variant interpretation and gene curation . As part of that project we have been using machine vision for recognizing phenotypes in photocopied clinical notes and I ve become a bit of an ontology guru . I ve developed skills in multiple languages across multiple compute platforms including AWS and SGE and tend to identify and take on greenfield projects . From time to time I ve taken on a product ownership role where required . I was Variant Interpreter product owner during its transition from a fledgling project to passing the Concept and Feasibility stages . I also worked on the Illumina knowledge base , Variant Interpreter genome browser used by Genomics England and others .. Technologies :",
Forschender Doktorand . Structural cryo EM and functional studies on the human MHC I peptide loading complex PLC . . Technologies : CryoEM,peptides;proteins;structure
"Computational Chemist , Machine Learning . . Highly motivated researcher completing a PhD in Computational Biology at Cornell University under the mentorship of Dr. Haiyuan Yu . Interested in a range of network and structural biology topics including protein protein interactions , predicting interface residues of these interactions , and characterizing the impact of missense mutations on interaction stability . Recently completed work employing drug and protein docking to characterize the protein protein interactome between SARS CoV 2 and human . Currently investigating machine learning methods to enable rapid virtual screening and de novo drug design with a focus on protein protein interaction inhibitors . Anticipated completion of degree in Spring 2022 .. Technologies :",
"Senior Principal Scientist . Currently lead a research laboratory and team whose primary concentration and work is the development of novel and innovative pharmaceutical treatments for debilitating diseases , including Cancer , Neuropathic Pain , and Tuberculosis . Additionally , I have successfully mentored and aided the learning of 20 volunteers , students , and postdoctoral fellows . I have made significant scientific advances and contributions during my tenure in this position , including : . The discovery and development of a novel platform for targeted protein degradation . Identification of novel inhibitors of HCN1 for the treatment of neuropathic pain . The establishment of a medicinal chemistry effort to develop novel nucleoside analogs that are active against adenosine kinase and submission of a lead compound for preclinical tox studies . The invention and development of a series of longer lived fluorescent dyes that have better photophysical properties than nearly all commercially available materials . The discovery and development of novel dextran cyclodextrin conjugates for the treatment of Niemann Pick type C NPC disease . The development of analytical techniques that allow for near real time detection of drug metabolism and intermediate metabolites of amino acid metabolism . Additionally , since 2006 I have , and continue to perform teaching activities and program Directorship roles within Weill Cornell Medicine that allow me to contribute to the learning and development of the up and coming scientific community . Programs and functions include the following : . Vice Co Course Director Molecules , Genes , and Cells . Course Director Organic Mechanisms ; Chemical and Biological Foundations of Medicine . Associate Director for Basic Science Atkins Foundation Curriculum in Metabolic Diseases . Problem Based Learning Facilitator Biochemistry Small Group Leader Molecules , Genes , and Cells ; Human Structure and Function ; Host Defenses ; Essential Principles of Medicine . An innovative and collaborative research scientist with 15 years of experience leading multidisciplinary teams and managing projects from concept to completion . Able to communicate a clear vision and develop a strong culture of teamwork , while making critical decisions during challenges . Entrepreneurial at heart , with a strong core belief of leadership by example . Exceptional track record of research success , with multiple publications and patents .. Technologies : Xray;NMR",molecular glues;small molecules;interaction
"Senior Scientist . Preformulation Advanced Drug Delivery . Energetic researcher with specialization in the activities of develop and characterise protein peptide based biopharmaceuticals and advanced formulations with a well rounded technical skills set e.g. production , purification , biophysical characterisation , molecular biology methodologies , U HPLC , CE SDS and MS analysis for these activities . I am seeking for a challenging role in the biopharmaceutical industry that utilises my previous skills and experiences and at the same time allows me to develop my professional skills even further . I consider myself a detail oriented person with a strong analytical mind and problem solving capabilities , able to work with different projects simultaneously and a team player , while learning and applying new aptitudes in a fast paced environment . . Technologies :",biologics;carriers;peptides;proteins;characterization;formulation
"Summer Research Intern . Prepared BL21 DE3 and BL21gold cells for protein production and future plasmid usage , respectively . Expressed , lysed , and purified 26 target protein cages using 96 well plates Used negative staining EM to visualize cage cores that contain the cargo protein of interest . Studied and utilized biological coding programs such as Python and MobaXterm for construction and visualization of proteins . . I am a masters graduate who has earned their masters in chemistry with a specialization in biochemistry . I have 3 years working in a biochemistry and bioinform tica research lab where i worked with bacteria growth and purification , sub cloning inserts into plasmid vectors , protein expression purification , site specific cleavage and radioactive calcium overlay assays . I have been awarded a special recognition in graduate studies award for being above a 3.8 GPA as well as awarded the RISE MS to PhD fellowship in the masters program . I am currently in a summer research fellowship program at UCLA called the DOE IGP fellowship program where I am being mentored in Dr. Todd Yeates lab in specialization in PYMOL coding and Cryo EM techniques . Prior to the educational accomplishments I have obtained , I worked 5 years as a private security officer , a year in retail as a salesman and a quarter of a year in food industry . . Technologies : CryoEM",proteins;structure
"Professor . . My lab employs new cellular and molecular technologies to tackle the most urgent and clinically important problems in cancer therapy , including functional genomics , drug screens , proteomics and single cell approaches . Critically , these technologies often generate the scale and complexity of data that necessitate the development of new computational algorithms to maximize their impact and fully understand their relevance in the clinic . The lab is focused on identifying mechanisms of drug resistance and targetable synthetic lethal interactions in breast and lung cancers since these diseases are deadly in the metastatic setting and demonstrate suboptimal tumor responses even with our best , most targeted therapies . We are committed to the identification , mechanistic dissection and clinical translation of new targets and target combinations through broad collaborations with biotechnologists , chemists , clinicians and pharma . Interested in joining us Please get in touch Find out more at : http : cancersignaling.net . Technologies :",
"Associate Professor . . https : amuntslab.org Our group at SciLifeLab explores the frontiers of the currently developing cryo EM methodology to visualize macromolecules that play key roles in fundamental and medically relevant cellular processes . We focus on technically challenging subjects , for which the molecular mechanisms have been least understood . One of the ongoing projects is to determine how the bioenergetic units that fuel life become to be . The lab members employ structural , functional and evolutionary analysis to study macromolecules that shape biological systems in mitochondria and chloroplast . The research is supported by the ERC , Wallenberg Foundation , SSF Future Leaders , EMBO Young Investigator Program and Cancer Foundation Junior Investigator Award .. Technologies : CryoEM",proteins;structure
"Associate Professor in Bioinformatics . Teaching and research in the field of genomics and bioinformatics . . Researcher , manager and educator who uses DNA sequencing , bioinformatics and computational biology in a broad range of projects , but especially focusing on emerging infectious diseases of crops . Specific interests and expertise include : plants , crop genomes , pathogenomics , banana , enset , Pseudomonas , Xanthomonas , Phytophthora , Perl , databases , MySQL , Linux , R , Python , applied bioinformatics . Email : d.j.studholme exeter.ac.uk Twitter : https : twitter.com davidjstudholme ORCID : https : orcid.org 0000 0002 3010 6637 Web page : http : biosciences.exeter.ac.uk staff profile index.php web i d david studholme . Technologies :",
"Director of Graduate Studies , BU Bioinformatics Masters Program . . Adam 's primary research interest is to better understand the genomics characteristics of neurodegeneration in human tissue using bioinformatics and machine learning approaches . His neurodegenerative disease research involves identifying commonalities and differences between different neurodegenerative diseases , with the goal of finding common pathological mechanisms that may lead to novel treatment modalities . He has particular expertise in the analysis of post mortem human brain tissue and cerebrospinal fluid transcriptomes , and has made significant contributions to our understanding of Huntington 's , Parkinson 's , and Chronic Traumatic Encephalopathy CTE . He also has methodological interests in metatranscriptomics in contexts ranging from Caribbean coral ecologies to connections between the central nervous system and the human microbiome . In addition to his independent research , he serves as Director of Graduate Studies for the BU Bioinformatics Masters program , as Director of Bioinformatics for the VA PTSD Brain Bank , and is a member of the BU Alzheimer 's Disease Research Center and BU CTE Center .. Technologies :",
"Guest Ph.D. Researcher . . Working on the structural biology of membrane proteins involved in the drugs nutrient transport . More specifically , interested in the role of secondary active human membrane transporters from the Solute Carriers family SLCs in health and disease . My aim is to decipher protein protein interactions , structural details and dynamics of SLC transporters by using different techniques , including LCP crystallography , negative stain , and cryo electron microscopy .. Technologies : CryoEM",membrane proteins;interaction;structure
"Teaching Fellow . I am a Teaching Fellow at the University of Oxford 's Department of Oncology . My current role applies my experience with particle physics , medical imaging , radiotherapy , data management , and clinical trials to departmental teaching . I am Director of Studies for the Department 's MSc Radiation Biology course . . I am a Teaching Fellow at the University of Oxford 's Department of Oncology . My current role applies my experience with particle physics , medical imaging , radiotherapy , data management , and clinical trials to departmental teaching . I am Director of Studies for the MSc Radiation Biology course . I started out in particle physics , working on the Compact Muon Solenoid CMS and Monopole and Exotics Detector at the LHC MoEDAL experiments looking for dark matter and magnetic monopoles respectively . While a Public Engagement Fellow for the UK Science and Technology Facilities , Council , I worked extensively in engaging wider publics with research and large scale computing through the Institute for Research in Schools IRIS and GridPP Collaboration , and the CERN school research programme . I then entered the world of medical imaging through the analysis of clinical and research neuroimaging datasets , including the UK Biobank , and Magnetic Resonance guided Radiotherapy MRgRT through my work with the ViewRay MRIdian MR Linac . I read Natural Sciences at Sidney Sussex College , Cambridge , specialising in Experimental and Theoretical Physics , and I completed my PhD at Imperial College London s High Energy Physics group and CERN . Homepage : http : www.tomwhyntie.com Specialties : Particle physics , dosimetry , medical imaging , machine learning , image processing , problem solving , coding C , Python , data analysis , public speaking , bringing science to a wider audience .. Technologies :",
"Senior Staff Scientist . Computational Biology technical project lead . Currently focused on building a novel pan coronavirus test , as well as providing support for a number of different genomic engineering projects . . Experienced Computational biologist with a strong background in next generation sequencing analysis , cancer research , general data analysis and some bench work . Skilled in Molecular Biology , Bioinformatics , Perl , C , R and python . Strong research professional graduated from Utah State University with a bachelors in chemistry and a minor in computer science . Did my PhD work at the NIH in the lab of David Landsman and my postdoctoral work at Stanford with Andrew Fire . . Technologies :",
"Associate Scientist in Analytical Development . DNA extraction and purification under rigorous sterility specifications . Quantification of viral genomes through RT qPCR on In Process Controls and Drug Substance and analysis of generated data . Purity check and protein identification using SDS PAGE and Western BLOT . Analysis of the images and calculation of the purity . HPLC analyses on Waters and Dionex using Empower and Chromeleon software . . I was supposed to become an archaeologist . Eight year old me dreamed of exploring pyramids , discovering dusty yet priceless treasures . Then high school science classes ignited my passion for the living world . Preparatory school biology lectures fueled it . The complex molecular mechanisms that allow us to breathe , trees to grow , fascinated me . I worked hard and it paid off : I got admitted to the National School of Biomolecule Technology of Bordeaux . I avidly learnt about cells , nucleic acids , proteins , metabolisms , and somehow managed to memorize the full Krebs cycle . I enjoyed my classes and blossomed during my internships . I knew I would never leave the laboratory . After I obtained my biotechnology Master 's degree , I heard about a wonderful job opportunity in Belgium . Two interviews and a ten hour ride later , I was starting my mission in Novasep . I joined Novasep 's Downstream processing team in May 2019 as an Associate scientist in Process and product development . Our goal Work hand in hand with our clients to develop and optimize their viral vector and antibody purification processes in a way that is the best to satisfy their needs . Working for a company contributing to advances in gene therapy is extremely rewarding to me . . Contact me at : 33 6 . 16 . 45 . 22 . 10 or astrid . thiry outlook . fr . Technologies :",
"Principal Research Scientist . . I have more than 20 years of experience in research , formulation , stability and biophysical characterization of peptides and proteins . Extensive experience from working in projects , both as project manager , coordinator , and project team member ; mainly in corporate projects but also from an EU project As a formulation scientist my key competences are : Physical stability of peptides and their propensity for amyloid fibril formation Co formulation combination products of two peptides and all aspects related to this wrt . physical chemical stability , biophysical properties and PK properties pharmacokinetics Requirements for formulations for in vivo studies and commercial drug products , and the impact of molecular design and formulation on pharmacokinetics As project manager I was responsible for delivering a research project into development , which is now an insulin GLP 1 combination on the market . Moreover , I have experience in handover of research projects to CMC , non clinical and clinical development . For a period I served as Work Package Leader in an EU project . I have a strong focus on innovation and IP opportunities resulting in more than 20 invention disclosures , patent applications and patents . In addition I am author or co author on 20 scientific publications , posters , oral presentations , and dissertations . I understand the development process of medicinal drugs from idea over research and clinical development to commercialisation , together with a clinical understanding of diabetes and obesity , and a growing interest for NASH . As a person I am calm and patient , thorough and persistent . I am self driven but keen on sharing knowledge , ideas and questions with new as well as old colleagues ; scientists as well as lab technicians . I thrive in project groups and subteams that drive projects forward in common . . Technologies :",peptides;proteins;characterization;formulation;stability
"Associate Principal Scientist . . Polyglot scientist with 6 year experience in pharmaceutical and biotech companies , particularly interested in drug design , molecular modelling , cheminformatics , and scientific writing .. Technologies : CryoEM",
"Associate Professor . The Reichow Lab applies biochemical methods , coupled with atomic level imaging and structure determination by cryo electron microscopy cryoEM to understand protein function . These structures provided key insight toward understanding how these biological molecules carry out the astounding functions that allow us to live . This mechanistic understanding provides a blueprint for developing novel approaches aimed at treating their abnormal functions found in disease and cancers . To learn more , please visit our website www.reichowlab.com . Specialties : Structural Biology , Electron Microscopy , Membrane Protein Biology . Technologies : CryoEM",membrane proteins;structure
"Senior Scientist . Senior Scientist in AbbVie 's Neuroinflammation with a focus on Alzheimer 's Disease . I am a dedicated scientist who loves to push the boundaries of human knowledge a bit further to help meet patients need . In the past ten years I gained tremendous experiences of different biological areas like agriculture , sepsis and thrombosis , cancer , as well as neuroscience . These areas all shared my main focus immunology in different kind of facets . Due to my extensive flexibility and demonstrated ability to learn quickly , I always fulfilled my goal to extend common knowledge . One of major attributes is creativity which I use to solve scientific mysteries . During my PostDocs in the DKFZ Bayer alliance and at AbbVie s Neuroscience I gained extensive insights in drug development . During these positions I worked at different areas of preclinical testing both in vitro and in vivo . I am looking forward to further expanding my knowledge to help increasing humankind s medical insight .. Technologies :",
Assistant Professor . . . Technologies :,
Postdoctoral Associate . . . Technologies :,
"Scientist . . Research Interest : Biophysical and functional characterization of ion channels with electrophysiological recording and bioinformatical profilings ; Membrane protein structure function relationships ; Ion channel physiology , pathology , and pharmacology . Publications : https : scholar.google.com citations user GjzbobQAAAAJ hl en Hobbies and achievements : Reading Translation : Zealous reader and translator for interdisciplinary books covering popular science and art . Belief 1 : Science transcends language . Road Trip Hiking : Belief 2 : Either your body or your mind should be on its way . Technologies :",membrane proteins;characterization;structure
"Senior Research Associate . Providing high quality critical reagents to enable the development of therapeutic antibody candidates . Executing biochemical analysis to support the development of drug candidates from pre clinical to clinical development , using wide range of modern biochemical techniques e. g. , CE SDS , HPLC UPLC , icIEF , etc and documenting methodically . Subject Matter Expert SME of instrument s . Optimisation of existing workflow . . . RESEARCH INTERESTS AND EXPERIENCE . . Bio engineering Sciences , Bio chemistry . Protein Engineering and Protein Structure . Antibody Separations and Biochemical Analytics . In vivo and in vitro Protein Protein Interaction . In vitro Bio physic and Bio chemical assay development . Technologies :",antibodies;characterization;engineering
"Head of Bioinformatics . Tagomics is an early stage startup that is implementing innovative solutions for epigenetic biomarker discover for the development of blood based clinical diagnostic tests . . Expert bioinformatician with experience from early stage biotech from seed to series B and beyond and leading cross functional teams . Involved in setting strategy , budgeting , hiring and pitching . Technical Expertise : Genomics WGS Exome Transcriptomics RNA seq Microarray Epigenetics Rare diseases Human metabolism and metabolic modelling FBA Drug repurposing . Technologies :",
"Postdoctoral Research Scientist . My current project is devoted to structural and functional investigation and search for novel inhibitors of mammalian respiratory complex I using cryo electron microscopy . Postdoc advisor : Leonid Sazanov . Experienced Postdoctoral Researcher with a demonstrated history of working in the research industry . Skilled in structural biology , biochemistry , molecular and cell biology with over 10 years of work experience . Last three years I focused on Electron Microscopy using both negative stain and cryo EM from sample and grid preparation to image acquisition , image data processing and model building .. Technologies : CryoEM",proteins;structure
"Staff Scientist P.I. . High resolution electron cryo tomography on structure determination of highly dynamic protein and soft materials . Individual Particle Electron Tomography IPET A single molecule structure Tracking 3D structure of protein chemical reaction Protein dynamics Protein structure and function Cryo ET , Cryo Electron Tomography Cryo EM , Cryo Electron Microscopy Lipoprotein LDL , HDL and CETP Lipoprotein structure Specialties : Individual Particle Electron Tomography IPET A single molecule structure Protein dynamics Cryo ET , Cryo Electron Tomography HDL , LDL structure . Technologies : CryoEM",proteins;structure
"Research , Training , and Publication Manager . As the manager of the UK EQUATOR Centre s training programme , I develop and deliver academic writing skills training on how to write fantastic health research articles . Most of our training is aimed at early career researchers , clinicians , and students and focuses on journal articles , such as our flagship two day Publication School . I recently developed online self directed courses on thesis and transfer report writing for the University of Oxford Medical Sciences Division 's Skills Training Programme . I have also worked with language professionals , such as author editors and journal editors , on integrating reporting guidelines into their practice . When not teaching writing skills , I lend mine to both the UK EQUATOR Centre and wider Centre for Statistics in Medicine CSM , providing editing and writing support for articles , reports , and grant applications . The UK EQUATOR Centre has an extensive research programme investigating the quality of research methods and reporting . I am often involved in these projects in a supporting role , and track the impact of our training . . I am a scientist by training and a writer editor by trade . I am fascinated by all things science related and love reading about and sharing new discoveries . I am passionate about helping disseminate science , especially by making it more accessible to the public and by polishing research to sound as good as it is .. Technologies :",
"Senior Research Scientist , Biophysics . . Protein biophysicist with a passion for disease research , drug development , and environmental sustainability . Experience working in multi disciplinary and multi cultural teams of chemists , computational biologists , clinicians , cell biologists , and biochemists to solve complex problems with global impacts . Offers diverse knowledge of molecular biology , protein structure function , protein protein interactions , and display technologies for biologic drug discovery . With over 10 years of scientific training , I am able to conduct a wide variety of experimental techniques with close attention to detail and critically analyze data . In my current position , I routinely establish assays to measure protein ligand interactions and conduct mechanism of action studies . I have acquired expertise in technical writing and oral communication , as demonstrated by award of a predoctoral fellowship , peer reviewed scientific publications , and multiple poster awards from scientific conferences . Key competencies : Biophysics , protein engineering , enzyme kinetics , assay development , protein purification , mammalian cell culture , mRNA display , yeast surface display , single domain antibody fragments , and molecular biology techniques like Gibson Assembly .. Technologies :",proteins;small molecules;interaction;structure
"Postdoctoral fellow . . You see chaos , I see predictive patterns . Unique Data scientist and experimental biologist with strong expertise in systems and quantitative biology sequencing , proteomics , high content imaging , math , statistics , bioengineering aiming to contribute to the data generation and data driven decisions . I have 7 years of experience in the development of high throughput methodologies and in computational data analysis in high level research at top institutions EMBL , UCSF . Developed novel multi omics Mass spectrometry and microscopy based platforms . Designed an integrative analysis workflow for proteomics , sequencing , and images based screenings , as well as statistical and machine learning based pipelines to make accurate decisions and hypothesis . I will make your chaos predictive . Expertise : Using linear methods , clustering , dimensionality reduction , network analysis network propagation , deep learning Neural Networks , time series analysis , ODE modeling and other modeling techniques to solve scientific problems . Developing novel high content imaging and proteomic techniques . Using integrative analysis of omics data Proteomics , RNA seq , Image based techniques for generating data driven hypothesis . Multiomics based assay development . Leading scientific research projects . https : github.com DmitKu . Technologies :",
"Scientist , Computational Biology . . Computational Biologist with experience in Next Generation Sequencing Analysis .. Technologies :",
Cryo EM Specialist . . . Technologies : CryoEM,structure
"QA Chemist . . Specialties : Quality assurance , quality control , ELISA , validation , molecular and cellular biology , GMP documentation , virology , cell signaling , GPCR pharmacology , scientific reports , quality control during vaccine production . Technologies :",biologics;quality
Principal Scientist . . . Technologies :,
"Associate Director , Group Leader , Global Discovery Chemistry GDC . VIVA award , Novartis Leading Scientist . A passionate and motivated leader and skilled medicinal chemist with 20 years of experience in exploratory research and early clinical development CFZ533 , LNP023 . Record of successfully leading programs from target identification to clinical candidate selection and or preclinical safety evaluation LNP023 . In depth knowledge in drug discovery , medicinal chemistry , lead optimization , fragment based screening and fragment based drug discovery . Enjoy working in multidisciplinary team : excellent collaboration skills and strong partnerships established with internal and external partners across disciplines biologists , pharmacologists , DMPK , clinicians , safety , CROs . Project management skills and longstanding managerial experience in mentoring , coaching and leading associates and PhDs . Author of several peer reviewed scientific publications , presentations at international conferences and co inventor of 22 patents including AVE5530 with completed Phase 2 clinical study . Technologies :",proteins;small molecules;screening
Research Group Leader . . I am interested in depth understanding how biological systems are working . I am seeking these answers by combining my biochemical knowledge and super resolution microscopy expertise . I am particularly interested in : 1 . Sequence specific DNA labelling in living cells . 2 . Probe generation for super resolution microscopy nanoscopy and their applications for living cell imaging . 3 . DNA protein organization in the cell and various DNA protein labeling methods . 4 . Development and application of labeling methods for imaging of cellular structures . 5 . High throughput screening and standardization methods used for cell biology .. Technologies :,
"GSK fellow alumni and Director of Scientific Engagement Innovation in NCE Molecular Discovery . . My current role is Senior Director of Innovation in the NCE Molecular Discovery department in Medicinal Science and Technology . I am a GSK Alumni Senior Fellow and an Adjunct Professor at Imperial College chemistry department developing links of mutual benefit to GSK and IC . . I am currently deputy chair of the Society of Medicines Research SMR . My role is to act an internal science consultant promoting and challenging ideas at the interface of chemistry and biology both within GSK and through our external engagement with academia . Recent activities include : . o Leading our Cell Concentration project which delivers methodology for determining the total and free cellular concentration of discovery molecules . Active engagement with our Chemical Biology groups developing new tools and technologies to explore new targets . . o Active engagement in projects including gene editing , protein stabilization , protein degradation , CETSA , single cell protein quantification , MS imaging , and medicinal chemistry . Previously I was a Director in Chemical Sciences at GSK in the UK responsible for leading departments involved in computational chemistry , protein crystallography , biophysics and protein MS . . o Since joining Glaxo in 1986 , I have been involved in the introduction and development of many key concepts in drug discovery including Computational Chemistry , Fragment Screening , Automation in Protein Crystallography , MALDI tissue imaging , Molecular Complexity , RECAP analysis , Cell concentration screening , and ligandability assessment . . o I have been at the forefront of our efforts to reduce attrition in drug discovery through focussing on physicochemical properties of compounds through data analysis . . Technologies : Xray",molecular glues;proteins;small molecules;expression;stability
"Scientific Director . . My overall research interests lie within protein degradation and proteolysis targeting chimera Protacs , an approach to target proteins for degradation by small molecules . Specialties : Ubiquitination assays , E3 ligase screens , xenografts , ERAD , tumor models , CRISPR and transgenic animal work .. Technologies :",molecular glues;small molecules;interaction
"Senior Process Specialist Formulation . . Accomplished biochemist with specialization in structural biology X ray crystallography and cryo EM , cell culture , and protein purification . Excellent team player with abundant experience in multicultural settings and presentations in front of large audiences . Enthusiastic singer and hiker .. Technologies : Xray;CryoEM",proteins;structure
"Staff bioinformatics scientist . . Dev lead of the Variant Annotation tool at Illumina , Inc. A Variant annotator is a scientific software that provides detailed information about genetic variants .. Technologies :",
"Senior Scientist . . A scientist with 16 year experience in protein characterization and antibody engineering . Proficient in molecular cloning , protein purification and characterization , and structural biology . Experience in antibody humanization , BLI SPR kinetics assays . Developed Python scripts to analyze sequecing data of anitobdy libriary and antiobdy screening hits . . Technologies : BLI;SPR",antibodies;characterization;engineering;interaction;structure
"IT Bioinformatics Manager . . Experienced professional with extensive background in IT , bioinformatics and laboratory research . Management of groups in both research and IT . Development of cost effective and maintainable laboratory and scientific software systems to support research initiatives and generate competitive advantages for companies . Strengths in : Biochemistry and molecular biology Bioinformatics Genomics Software development Business analysis Project and portfolio management Personnel management , including coaching , mentoring and career development . Technologies :",
"Senior Associate Scientist . . MS in medicinal chemistry specializing in organic chemistry with 20 years of experience in synthetic organic and medicinal chemistry Extensive track record of drug discovery accomplishments 11 patents , 12 ACS conference presentations , and 15 peer reviewed publications as author and coauthor Expert in modern medicinal chemistry approaches discovered several linkers and modified E3 ligases ligands in developing therapeutic PROTAC mediated protein degradation Broad understanding of drug discovery and relevant disciplines chemistry , biology , toxicology , DMPK Involvement in external collaborative projects with CROs . Excellent communication skills both written and oral . Technologies :",molecular glues;screening
"Senior Scientist . . Structural biologist and biochemist with 12 years of experience in structural and functional studies of enzymes , transporter proteins from humans and plants . Expertise in membrane and soluble protein biochemistry , molecular biology , nanobody screening , X ray crystallography , Cryo EM , yeast fermentation , mammalian cell culture , cell sorting , surface plasmon resonance , and cutting edge optical techniques such as Bio Layer Interferometry BLI . Highly proficient in computer skills for bioinformatic analysis of protein structures and protein ligand protein protein interactions . Strong written , verbal communication , and editorial skills . Excellent supervisory experience with small , interdisciplinary teams of researchers in leading multiple projects and building successful collaborations .. Technologies : Xray;CryoEM;BLI;SPR",enzymes;membrane proteins;proteins;small molecules;interaction;structure
"Bioinformatics Warehouse Research Coder Manufacturing Stage Bartender . Bioinformatics , Warehouse , Research , Programmer Coder , Manufacturing , Stage Production , Bartender . SKILLS BIO TECH : 1 . Concepts Bioinformatics , Computer Modeling , Object Oriented Design , OLAP Design 2 . Languages C , C , HTML , XML , BioJava , BioPERL , JavaScript , PHP LAMP , UML 3 . Bio Databases Genbank , EMBL , Swiss Prot , Entrez , search engine , SDSC Workbench 4 . Bio Applications BLAST , FASTA , S W , CLUSTAL W , PAM , BLOSUM , Rooted Unrooted TreesOracle : Created multiple canvas forms using data blocks , triggers SQL stored 5 . Databases Oracle , SQLplus , MySQL , Molesoft , Crystal Reports , Star Schema Design Biological : General Biology , Microbiology Immunology , Biology , Biotech , Statistics BIO TECH DESIGN : 1 . C C Developed menu driven , object oriented . 2 . Internet Programming Designed developed software ; maintained web sites web applications using HTML , Cascading Style Sheets , PHP , Java Server Pages Dreamweaver 3 . Java Developed Apps . using object oriented methodology , inheritance , polymorphism . Wrote Java Applets using graphic GUI components 4 . SQL Created maintained relational database tables views ; establishing complex multi table relationships variety of joins procedures . 5 . Visual Basic Create a graphical user interface design to maintain a SQL database table . 6 . Crystal Reports Used to develop report apps . , populated by raw derived data , generated by complex , multi nested T SQL queries . 7 . UNIX Develop shell scripts . 8 . Bioinformatics basic tools for complete biotech procedures for sequence alignment , to build databases , analysis of DNA RNA protein properties . CLIENTS : OS 95 , Windows 10 , Mac 9.0 on , UNIX , Linux NETWORKING : TCP IP , ISO OSI , Ethernet , Proxies , VPN BIOLAB : Concepts w cGMP quality system ; basic knowledge of autoclaving glasswares autoclavable materials ; preparing common medium solutions reagents according to established SOPs . ARTS DESIGN : Molding Casting Foam Sculpting movie production set design , Sculptors Model , Graphic Design , Photoshop , Illustrator , Quark , Typography , Pastels , Acrylics , Oils , Scratchboard , Pottery , Photography , Dancer , Fashion Consultant Model . ADMIN SHIPPING : Clerical , typing 45 wpm , 10 key , business math , light accounting , Windows , Excel , Power Point , Shipping Verification w UPS , Courier , FEDEx , Interpersonal , fiber optics splicing , sales , sales reporting , stock inventory , warehouse , load , unload , puller , packer , palletizer , forklift cert . HOSPITALITY : Restaurant Manager , Train Staff , Chef , Cook , Host , Bar Manager , Bartender , Barback , Stocker , Order Inventory , POS , Corporate Retreats , Credit Cash , AZ state certified in basic manager liquor control courses .. Technologies :",
"Doctoral Student , SFB 1208 Fellow . Structural and functional characterization of ESCRT protein complex from Drosophila orthologs using Cryo EM and in vivo genetics . . Technologies : CryoEM",proteins;characterization;structure
"Scientist . . After my PhD in molecular and cellular biology , with a focus on oncology and my postdoc in protein engineering during which I developed new affinity peptides , I am now working in Salipro Biotech company . We have a unique platform to get membrane proteins in solution without any need of detergent . This enables accessibility of membrane protein drug target and allows the development of next generation therapeutics . As a person I am positive , driven and proactive . I am also curious and I enjoy learning .. Technologies :",membrane proteins;characterization
Associate Professor . . Interested in structural and functional characterization of membrane proteins . www.autzenlab.com . Technologies :,membrane proteins;structure
"Staff Biological Data Scientist . . Highly self motivated and focused on innovative research and engineering , I enjoy identifying , creating and delivering solutions to big problems through critical thinking and analysis . With a diverse background in mechanical engineering , molecular biology and computer science , and experience in market research and product development , Javier has built technologies to make a more predictive biology integrating cutting edge modeling , computation and experimental measurements . As synthetic biologist , his work has demonstrated how comprehensive computational models in bacteria can enable design , interpret complex behaviors , prioritize experiments , and facilitate discovery . 10 years of Systems and Synthetic Biology research experience managing multiple interdisciplinary research projects resulted in more than 35 scientific articles . 12 years of coding experience using script and object oriented programming languages : Awk , bash , C C , MatLab , Python R , Mathematica , Latex , Unix , Linux . Designed , implemented and presented time sensitive projects both in oral and written . Extensive mentoring experience guiding undergraduate and graduate students from various background at Polytechnic U. Valencia , cole Polytechnique Paris Saclay , UC Davis , UC Berkeley , Stanford , and Imperial College London . Specialties : Whole cell mathematical modeling , comprehensive integration of heterogeneous datasets , large scale dynamical modeling , multi scale mechanistic modeling . Software development , databases , statistics , machine learning , algorithms for multi objective optimization , data visualization . Experimentation in cloud labs ; ability to connect biology , computation and modeling . Customer segmentation , market research , licensing , business assessment , design thinking . Selected as Spanish Top Talent in 2017 by MIT Technology Review Innovators under 35 Highlighted by Web of Science PLoS ONE as Synthetic Biology Main Scientific Contributor National Interest Waiver EB2 . Technologies :",
"Principal Scientist , Computational Biology . . I am currently a computational biology principal scientist at Zentalis , building pipelines and infrastructure to support multi omics data analyses and collaborating with discovery biology to identify and understand mechanisms of cancer . My previous work experience was at Boundless Bio as principal bioinformatics scientist , performing research on extrachromosomal , circular DNA ecDNA . This work is an extension of my postdoctoral research in Dr. Vineet Bafna 's lab at UCSD , where I focused on understanding the impact of ecDNA on cancer biology and the role of viral integration in cancer cell evolution . I started my postgraduate career at the Carl R. Woese Institute of Genomic Biology at the University of Illinois in 2014 under the supervision of Dr. Rebecca Stumpf , Dr. Bryan White , and Dr. Tandy Warnow . My postdoctoral research topics analyses included comparative analyses of the microbiomes of primates , phylogenomic analyses of lice , and the development of novel methods for sequence homology detection and multiple sequence alignment .. Technologies :",
"professor emeritus of molecular physology . . Established a research group at the Institute of Physiology , University of Aarhus 1965 1900 to succeed in purification of the Na , K pump from mammalian kidney and to resolve the functions of the Na , K pump in the tubules of the mammalian kidney . From 1990 2005 professor of molecular physiology at the University of Copenhagen . Established a research group in the Biomembrane Research Center to develop molecular biological methods for heterologous expression of membrane proteins in yeast . Published more than 160 articles and invited reviews on purification , structure and physiological functions of the Na , K pump and K channels in mammalian kidney . Also several articles on the Ca pump in skeletal muscles and the H pump in higher plants . These articles received more than 7800 citationer ISI 2011 . Hirsch factor : 49 artikler cited 49 times or more . Lecturer or chairman at a large number of international symposia and congresses .. Technologies :",membrane proteins;expression
"Principal Bioinformatics Scientist II . Design bioinformatics methods pipelines and support assay optimization for product development in NIPT precision oncology . I am an experienced scientific professional with proven track record of solving complex biomedical problems using innovative , advanced data analytics . My expertise includes bioinformatics , signal image processing , statistics and machine learning . I am passionately dedicated to advancing precision medicine to make a difference in patients journey .. Technologies :",
"Associate Director R D Project Management and Development Strategies . R D project leader for NASH siRNA program . Drug discovery professional with 15 years of international experience in cardiometabolic research in academia and industry leading people , teams , projects , and collaborations . In depth knowledge of unmet medical needs in indications of cardiometabolic diseases and experience in small molecule , peptide , and antibody based drug discovery from target identification , validation up to early clinical development with a strategic perspective and vision for biomarker and translational research to facilitate early de risking and decision making . . Technologies :",antibodies;peptides;proteins;small molecules;developing
"Lead of Bioinformatics Team , Senior Computational Biologist . Lead the IDEXX Database development and maintenance . Lead the Bioinformatics Team to do product pipeline and platform development through the collaboration with IT team . Established and maintained the cloud computing environment for IDEXX . . Thirteen years of programming experience in bioinformatics . Ten years of large genomic data analysis experience . Independently designed novel algorithms including dynamic programming and parallel computing to solve next generation sequencing data analysis problems . Completed the software development and keep active software maintenance . Specialties : C C programming , Perl programming , R , database construction , Unix Linux , cluster farm usage LSF , SGE , high performance computing , parallel computing , version control Git , SVN , Hidden Markov Model , big next generation sequencing data analysis , cloud computing virtual machine , Docker , HLA typing , population evolutionary genetics , systems biology .. Technologies :",
"Research Associate Epigenomics . . Skilled in Bioinformatics , Biostatistics , Epigenomic Assays : ATAC seq , ChIP seq , Single Cell Genomics , Cell Culture , qPCR , Western Blot , Sequencing , Experimental Design , Data Analysis , Programming . Technologies :",
Research Fellow in Neuromorphic Olfaction and Robotics . . . Technologies :,
"Senior Computational Biologist . . Research scientist cross trained in computational and experimental biology . Extensive record bridging proteomics technology and computational statistical thinking to open problems in biology . My experiences include projects in areas of infectious diseases , exercise biology , and cancer . I have a passion for the acquisition , analysis , and integrations of large biological datasets in innovative ways to better understand the molecular basis of human diseases and drive the discovery of novel drug targets and therapeutics . List of publications : https : www.ncbi.nlm.nih.gov pubmed term Jean Beltran . Technologies :",
"Staff Scientist . . 10 years of research experience in the field of neuroscience with 4 years specializing in microglia physiology involved in neuroinflammation following injury and neurodegenerative diseases Excelled at working independently or as part of a team Excellent analytical skills i.e. identifying needs , gathering information , investigating ; observing , analyzing information data ; evaluating ; solving problems Laboratory skills : dissecting nervous system tissue , generate primary cell cultures i.e. neurons and microglia from neonatal and adult rat and mouse and cell line MLS 9 microglia Electrophysiology : whole cell and perforated patch clamp recordings Molecular Biology techniques : DNA , RNA , and protein isolation , PCR , real time PCR , data analysis for Nanostring , western blotting , assays for microplate readers , Ca2 imaging , immunocytochemistry , and fluorescence microscopy . Computer Skills : Microsoft Office , Origin , pClamp , AxioVision , Image J , GraphPad , SPSS , Endnote , Mendeley . Technologies :",
"Lab Manager . . Experienced Graduate Research Fellow with a demonstrated history of working in the higher education industry . Skilled in FTIR , GPC , UV Vis Spectroscopy , Rheology , and Differential Scanning Calorimetry . Strong research professional with a Doctor of Philosophy PhD focused in Polymer Plastics Engineering from The University of Akron . . Technologies : DSC",
"Technical Lead , Bioinformatics Engineering . . Experienced Bioinformatics Engineer with a demonstrated history of working in the biotechnology industry . Skilled in Bioinformatics Pipelines , Tools , Databases , Continuous Integration , Web Applications , R , and Algorithms . Strong research professional with a Master of Science M.S. focused in Computational Biology .. Technologies :",
Computational Biologist . . . Technologies :,
"Senior Bioinformatics Scientist . Working at the NIHR funded Biomedical Research Centre at Guy 's and St Thomas ' NHS Foundation Trust in affiliation with King s College London . I am involved in translational research including : developing data pre processing and statistical analysis pipelines , using R , Stan and MySQL . Using multiple analysis techniques and models , including Causal analysis , Mixed effects hierarchical models , dimension reduction and clustering , regression approaches with custom Bayesian regression models using numerical or monte carlo optimization techniques . . I am a biological data scientist with a Medical Degree , MSc with distinction and PhD in bioinformatics with extensive experience in providing bioinformatics solutions to big data problems using Causal models , Machine learning , Bayesian statistical and Graph Network based methods for estimation , prediction , decision making , clustering and dimension reduction . My portfolio includes many projects https : github.com uhkniazi including publications in Nature Materials IF : 47.66 , Lancet Infectious Diseases IF : 71.4 , Journal of Allergy and Clinical Immunology IF : 14.29 , Nature Communications IF : 17.69 and others . Some examples of achievements include : Biomarkers for peanut allergy prediction in children Journal of Allergy and Clinical Immunology 2021 ; The Journal of Allergy and Clinical Immunology : In Practice 2022 . Biomarkers for Tuberculosis diagnosis The Lancet Infectious Diseases 2021 . Predicting patient prognosis in COVID 19 Patients Nature Communications 2021 https : doi.org 10.1038 s41467 021 23494 1 . Statistical software development for identifying stranded DNA Methylation DISMISS : detection of stranded methylation in MeDIP Seq data . BMC Bioinformatics . 2016 . Whole genome analysis of a schistosomiasis transmitting freshwater snail Nature Communications 2017 ; http : www.bbc.co.uk news science environment 39928036 Patent : Biomarker discovery for diagnosis of active tuberculosis . filed 2016 . Biomarker for latent tuberculosis stratification Stratification of latent tuberculosis infection by cellular immune profiling . J Infect Dis 2017 . Developing software to calculate mutation rates in Influenza virus https : github.com uhkniazi HPRU Flu Evolution . My interests include : Causal models . Bayesian statistics . Graphs and networks . Biomarker discovery . Statistical and Machine Learning methods . Clustering , Dimension Reduction and Shrinkage . Markov Chain Monte Carlo MCMC simulations . High dimensional data modelling . Bioinformatics and Cheminformatics Longitudinal Case Control Studies . Next Generation Sequencing NGS data analysis . Single Cell Sequencing data analysis .. Technologies :",
"Research Data Analyst . Palmer Lab Genotyping pipeline development and optimization . Machine Learning , Bioinformatics , Computational Biology , Genetics , Genomics , Microbiome . Technologies :",
"Senior Principal Scientist . . Biochemist , Biomarkers and Proteomics Expert . 20 years experience in drug discovery and development , across various disease indications and therapeutic modalities . Latest focus : applying innovative technologies to therapeutic antibody development in immuno oncology programs . Most recent highlight : high impact scientific and experimental contributions to MHC bound peptide detection in patient tumors . Currently developping technical strategies for translational biomarker discovery and quantification . . Technologies :",antibodies;proteins;developing;interaction
"Principal Scientist Computational Antibody Protein Engineering . Enable virtual screening of antibodies sequences for binding to antigens by analyzing NGS outputs , B cell repertoires and other sources of antibody sequences Support novel biotherapeutics discovery by providing bioinformatics , molecular modeling and simulation based inputs to research plans directed at engineering novel biotherapeutics by implementing molecular modeling as well as machine learning based methods . Design sequence libraries for multi factorial optimization of candidates for antigen binding , stability , function and drug like properties . Work with multi disciplinary groups of experimentalists , including those involved in protein expression , purification , biophysical characterization and drug development . Proficiently execute assigned tasks in bioinformatics , homology based antibody modeling , molecular dynamics and Monte Carlo simulations . Establish an international reputation in area of expertise with publication and conference participation ; represent BIPI as a scientific leader in field of expertise at both internal and national international conferences , meetings and organizations . Comply all applicable regulations , performing all work in a safe manner ; maintain proper records in accordance with SOP s and policies . Contribute towards mentoring colleagues . Development of in silico tools for the design of biological therapeutics . Specialties : Antibody engineering , bispecific antibodies , structural biology , modeling of protein protein interactions , DNA and protein sequence analysis , software development and design .. Technologies :",
"Bioinformatician . Performed genome wide association studies GWAS and heritability analysis on data from various cancer studies . Experienced in genome imputation with 1000 Genomes and UK10k data . . Research interests : Molecular genetics and genomics , gene expression analysis RNA Seq , microarrays , eQTL analysis , data visualisation , germline WGS genetics , variant effect prediction , deep machine learning Specialities : Bioinformatics , biostatistics , genetics and genomics , 3D DNA HiC , promoter capture HiC , 3D de novo genome assembly , genome wide association studies , microarray data analysis , nonlinear regression , Mendelian randomisation , polygenetic genetic risk scores , Python , R , high performance computing , Currently investing the non coding parts of the genome , and the influence of enhancers on gene expression using perturbSeq . Technologies :",
Associate Principal Scientist Early CVRM PROTAC Lead . . . Technologies :,
"Postdoctoral Fellow . Coordinating projects in targeted , quantitative proteomics , structural proteomics and cryo electron microscopy cryo EM . . Structural proteomics , targeted proteomics and cryo EM . Technologies : CryoEM",proteins;structure
"Postdoctoral Research Fellow . . Self motivated and enterprising researcher with expertise in molecular biology and biochemistry in molecular machines such as topoisomerases and SMC complexes . Expert in recombinant protein purification using diverse expression systems bacteria , yeast and insect cells , biochemical and biophysical characterisation of protein complexes . Currently being trained in Cryo EM technique . Additionally , large experience in moving and setting up an entire new and vanguard biochemistry laboratory from EMBL Heidelberg to the recently inaugurated department of Biochemistry and Cell Biology in the Julius Maximilians Univertit t W rzburg .. Technologies : CryoEM",proteins;characterization;structure
"Head of Targeted Radiopharmaceuticals Research Early Development Oncology . . Project manager focused on the development of radiolabeled immunoconjugates antibody drug conjugates from research to early clinical development . Broad scientific background with excellent analytical and strategic skills , able to work independent and structured . Capable of handling several and complex projects in parallel . Leadership competence with data driven decision making skills . Team player with strong interpersonal , networking and relationship skills . Fluent in German , English , Norwegian and French .. Technologies :",antibodies;developing
"Postdoctoral Researcher . . What is going on inside our cells If you are as curious about that as I am , read on Our cells contain a whole zoo of marvelous machines proteins which fulfil all kinds of tasks . I want to help understanding this nanoscopic world by making it visible and help other scientists on their journey . The tool of choice nowadays is cryo electron microscopy . Either by looking at isolated complexes , so called Single particle analysis SPA , or by imaging the machines in their native context within cells which is referred to as cryo electron tomography cryo ET my favorite . I did my PhD in the Department of Prof. Wolfgang Baumeister MPI of Biochemistry and was trained by Prof. J rgen Plitzko MPI of Biochemistry and Julia Mahamid EMBL Heidelberg . When I started out with cryo ET , I was completely overwhelmed by the complexity of the method . Back then , I could not believe that I would ever be able to acquire my own data . But that is only half the work . Each cryo ET project is different and requires you to deal with several software packages and write your own analysis scripts to deceiver the secrets within cells . I started with barely any programming experience and was afraid I can not live up to the task . Well , I was wrong . Step by step and with the support of my amazing teachers I gained confidence with programming languages worked on SPA projects resulting in a paper and mastered the whole cryo ET workflow . My PhD time showed me the importance of dedicated teachers if you want to learn cryo ET . Furthermore , I understand that people new in the field are steamrolled by its complexity I have been there as well Hence , I would like to work in a research group or facility , where I can help scientists to get started , to use the microscopes and to analyze the data so that we can admire together this nanoscopic world that is underlying all life . I am a social person and all in for chat and activities outside of the everyday work . I was actively playing soccer for 18 years . That made me understand the importance of teamwork and of a positive atmosphere for success . I am a team player and able to generate a pleasant but productive working atmosphere . If you want to know more about me or my work , feel free to contact me . Technologies : CryoEM",proteins;structure
"Academic Employee . National Food Institute . Innovative scientist with 15 patent applications covering 4 clinical stage compounds . Supervisor , mentor and teacher for younger staff , post docs , Ph . D , attachment and bachelor students . Science communicator with experience writing teaching materials , SOP 's , project status reports , scientific papers and speaking at international conferences . Experienced project and group leader working on both science and technology projects . Experience managing projects with several external collaborators . Data analyst with multi variate statistics and machine learning experience . Experience with planning and outsourcing synthetic chemistry , assays profiling and managing CRO FTE s. Experience with most separation and analytical chemistry methods for analyzing organic and inorganic substances . Experience with most modalities including fragments , small molecules , macrocycles , irreversible inhibitors , protags , peptides including stapled and peptidomimetics . Extensive experience employing computational chemistry , chemoinformatics and ADME Tox tools Proficiency in writing and implementing web based interfaces for chemoinformatics , ADME Tox and computational chemistry software . Worked on diverse targets including kinases , GPCRs , transporters , proteases , transcription factors , PPIs and epigenetics . Human as well as bacterial and viral proteins . Mobile : 45 93959091 , e mail : anders colours.dk . Technologies :",
Researcher . Formulating a theory of particle number conserving Majorana zero modes in 1D p wave superconductors and 2D p ip superfluids . Advised by Dr. Ivar Martin . . . Technologies :,
"Research Specialist . Developing data processing and analysis pipelines to assist ongoing cancer research at MIT . I am a student and scientist working at the intersection of biology and computer science . With experience on a series of projects involving hardware hacking , data science , and biomedical simulation , I have developed my academic and professional skills . Currently , I am pursuing a graduate degree in computational biology to challenge myself further and discover new ways to improve healthcare .. Technologies :",
"Study Director Analytical Physical Chemistry . Method development and validation for quantification of pharmaceuticals , industrial and agro chemicals in various samples formulations , animal food , water . Physico chemical characterization of chemicals required for registration under REACH and EMA . . Method development and validation for quantification of pharmaceuticals , industrial and agro chemicals in various samples formulations , animal food , water . Physico chemical characterization of chemicals required for registration under REACH and EMA . Specialties : . Mass spectrometry : . MALDI ToF MS . LC ESI MS MS . Chromatography : . SEC and HPLC coupled with different detectors RI , MALLS , PAD , viscometer . Spectroscopy : . UV VIS IR . Fluorescence . H NMR . Upstream and downstream processing of proteins in E. coli , L. lactis and Pichia . Protein purification using HPLC and FPLC . Protein characterization . Immunochemical methods : . ELISA . Western blot . Antibody purification . DNA RNA isolation and purification , PCR . Different cloning techniques , vector systems applied with E. coli , L. lactis and Pichia pastoris . Bioinformatic tools . Technologies : NMR",
Scientist Application Development . . Protein Biochemist with six years hands on experience downstream processing large protein complexes virus like particles and vesicles development of novel purification protocols protein engineering enzyme kinetics structural biochemistry Cryo EM and X ray crystallography protein protein interaction molecular biology techniques open minded team player . Technologies : Xray;CryoEM,carriers;proteins;interaction;structure
"Senior Computational Biologist . . I enjoy doing research in quantitative , computational biology . Specialties and Interests : Functional Genomics , Gene Regulation , NGS data , Machine Learning , Predictive Modeling , Data Mining and Visualization , Bayesian Models , Developmental Biology , and Cancer Genomics . Link to Github page : https : github.com dineshmdh Example Project : https : github.com dineshmdh predicting gene expression . Technologies :",
"Postdoctoral Research Assistant . in the Team of Prof. Niels Volkmann , Structural Image Analysis 2021 to present in the Team of Prof. Dorit Hanein , Structural studies of macromolecular machines in cellula 2020 21 Working on Cryo EM Single Particle Analysis of Membrane Proteins in lipidic environments , aiming to achieve native 3D atomic structures to better understand highly relevant biological mechanisms . . Researcher , Biochemist , Life Sciences ORCID number : https : orcid.org 0000 0002 1593 5648 . Technologies : CryoEM",membrane proteins;proteins;structure
Quant Data Scientist . . Quant in oil analytics team . Building data analytics platform and quantitative trading infrastructure . Researching and developing machine learning and rule based systematic strategies with focus on energy commodities .. Technologies :,
"Senior Scientist , Bioinformatics . Oncology Integrative Analytics group in the department of Genome and Biomarker Sciences . . Experienced computational biologist specialized in handling and analyzing NGS multi omic data WES , WGS , RNA seq , scRNA seq . My research focuses on understanding how genetic variation impacts the gene function in anti cancer drug responses , such as immunotherapy and chemotherapy . . Technologies :",
"Visiting Academic Alexa AI . . Dr. Emilio Ferrara is Associate Professor at the University of Southern California , and Amazon Visiting Academic in Alexa AI . He s also Research Team Leader at the USC Information Sciences Institute , and Principal Investigator at the USC ISI Machine Intelligence and Data Science MINDS group . Ferrara 's research interests include using AI for modeling and predicting human behavior in techno social systems . Ferrara has published over 150 articles on AI , social networks , and network science , appeared in venues like Proceeding of the National Academy of Sciences , Communications of the ACM , Physical Review Letters ; his research has been featured on all major news outlets . He was named 2015 IBM Watson Big Data Influencer , he received the 2016 DARPA Young Faculty Award , the 2016 Complex Systems Society Junior Scientific Award , the 2018 DARPA Director 's Fellowship , and the 2019 USC Viterbi Research Award . His research is supported by DARPA , IARPA , Air Force , and the Office of Naval Research .. Technologies :",
"Research Fellow in Bioprocessing and glycan engineering . Research : A collaborative project funded by SFI , Enterprise Ireland and Agilent Technologies to promote AdvanceBio Gly X product lines for high throughput and high resolution glycan profiling , and produce homogeneous glycan forms of monoclonal antibodies by solid state chemo enzymatic transformation . Responsibility : . InstantPC N glycan GU database construction and cross validation . Experimental methodology design , development , optimization and cross validation . Upstream CHO cells culture . Downstream antibodies purification and characterization . Glycan analysis and In vitro chemoenzymatic glycanengineering . Glycan based disease biomarker discovery . Correlation between antibody functions and glycan remodelling . Project management and technology transfer . Upstream bioprocessing optimization and intensification . Downstream recombinant protein or antibodies purification and characterization . Antibody drug conjugation . Bioassay methodology development and cross validation . Cellular metabolism and medical diagnostic and prognostic biomarker discovery . Technologies :",antibodies;characterization;developing
"Senior Scientist Cell Based Assays . As the Senior Scientist in Cell Based Assays , I am responsible to implement the unit for cell based potency assays within the organization , and I am involved in the biopharmaceutical development process of our clients . I am responsible for the development and validation of cell based assays in GMP environment to assess the impact of pre existing antibodies and induced immune response . I will be establishing a bio analytical package to support the testing and release of antibody and drug products , as well as delivering data and reporting to our clients according to high scientific and quality standards . In adittion , I am responsible for managing and training of small team of 6 7 people with in depth technical knowledge in assay development . . I am a motivated Biomedical Scientist with extensive experience in Life Sciences , Cell molecular biology , and . Immunology . I have more than 8 years of relevant Preclinical R D experience in academia PhD and post doc and more than 2 years in biotech pharma in immunotherapeutic products and antibody technology including design , selection and evaluation in in vitro and in vivo models . I am currently responsible for the development and validation of cell based assays in GMP environment to assess the impact of novel therapeutic products mRNA vaccines , CAR T cells and antibodies and induced immune response . . Technologies :",antibodies;developing
Staff Machine Learning Scientist . . . Technologies :,
"Head of Science . Managing the Research Science its team its Strategy its marketing of a major software vendor for pharma biotech biologics top league of companies Initiated and led the team behind the award winning software Genedata Imagence , an AI deep learning based high content image analysis which won both , BioIT World Best Practices Award 2018 and the Best of Show Award at BioIT World in 2019 . Works hard on better real high throughput data analysis for large molecule assays Biologics , to enable industry leading analysis of Epitope Binning , Biosensor and Flow cytometry based data analysis and quality control . Uses statistical , and AI based models to reach a 100 automation of data analysis of complex mechanistic or biophysical assays , in production ready quality e.g. , in biophysical mechanistic screening , like modality of inhibition or slow binding or SPR . Evolves data quality control in both small molecule and for biologics drug discovery pipelines . Works with a global team global collaborators and global customers in all geographies . Solves analytical needs of cutting edge technology or new drug modalities , like e.g. for PROTAC assays to achieve accurate result paramaters , automatically , when lots of data is generated . Continuously work on Automation Data Science and the Lab of the Future concepts , discussions , real work . I believe in science and logical reasoning . A deep understanding of problems , the search for efficient best solutions and for their implementation based on agile , lean , efficient , reusable methods and defining standards drives my work . By initiating and executing research projects to provide truly working software solutions for ' hard ' problems on an industry enterprise scale . During consulting projects , product development and during application of cutting edge technologies with almost every leading pharma companies and research organizations . Specialties : Process Data Analysis Automation , Scientific Consulting , AI Deep Learning , Customer Relations , Automated Screening Technologies , Mechanistic Screening , Multivariate Data Analysis High Content Screening . Technologies : SPR",
"Postdoctoral Research Fellow . Project : Microfabricated cell culture platforms for cryo EM and mechanobiology . Advisors : Prof. Alex Dunn Chem . Eng . , Prof. Beth Pruitt Mech . Eng . , Prof. Bill Weis Biology Develop microsystem based methods for cryo electron microscopy cryo EM . Pioneered the use of extracellular matrix ECM micropatterning for 3D cryo EM of cells , dramatically improving the rate of data acquisition . Study endothelial cell cell junction architecture using cryo EM tomography . Develop microfluidic platforms to spatially control stem cell differentiation . Develop silicon microelectromechanical systems MEMS to shear cell monolayers . . A dream come true : the Engel lab will be opening its doors at the Technion 's Faculty of Mechanical Engineering October 2022 Our research lies at the intersection of microsystems and biology . We will develop new bio MEMS and cryo EM methods with a focus on understanding how cells sense mechanical forces from their microenvironment . I will be hiring a lab technician and graduate students so please do connect me to any potentially relevant candidates I am very much looking forward to mentoring , brainstorming , teaching and talking science over coffee in my new role at the Technion .. Technologies : CryoEM",
"Early Stage Researcher Cryo EM Scientist . . During my undergraduate studies , I focused on gaining expertise on protein biochemistry , computational biology and protein modelling , as well as protein crystallization and x ray crystallography . After completing my BSc , I decided to enhance my computational biology skills by completing an MSc in Systems Biology , where I specialized in Proteomics and Drug Repositioning . I am now an Early Stage researcher in the Kastritis Laboratory for Biomolecular Research , focusing on Cryo EM of large biomolecular assemblies , where I can employ all previous skills to derive insights on protein structure and interactions of the proteins taking part in complex processes .. Technologies : Xray;CryoEM",proteins;interaction;structure
Senior Scientist . . Protein chemist with project management experience . Expertise in the production and biochemical biophysical characterization of globular and disordered proteins . Area of expertise : Protein chemistry . Enzymology . Protein engineering . Sequence structure function . Protein oxidation . Protein misfolding and aggregation . Protein stability . Biochemical Biophysical Characterizations . Molecular modelling . Data analysis . Project and People management . . Technologies :,idps;proteins;characterization;engineering
"Sr QA Specialist C GT QA Ops Local Qualified Person . . QUALITY ASSURANCE : QA Specialist Cell Gene Therapy , QA Operations QUALITY CONTROL : Postgraduate QC Specialist ad interim LabCoordinator Teamlead , Nutrient Media Release QUALITY CONTROL : Postgraduate QC Specialist , Team Release Sterility Bioburden , QC Microbiology QUALITY ASSURANCE : Quality Engineer , Alcon Grieshaber AG RESEARCH : Microbiology Biochemistry , Institute of Medical Microbiology IMM RESEARCH : Cryo Electron Microscopy Cell Adhesion , Department of Biochemistry UZH DIPLOMA : M. SC . Biochemistry , UZH DIPLOMA : EFZ Construction Draftsman technical maturity , WSP AG . Technologies : CryoEM",biologics;quality
"Researcher . o Independent planning , execution and analysis of experiments and accurate documentation of research activities , ensuring follow ups and reporting on projects progress to collaborators o Reviewing manuscripts with complex scientific content for high impact factor journals such as ACS Omega since 2016 o Developed a new structural biology project idea and established international collaboration on it o Training of users for large scale protein expression bioreactor and crystallization robot o Development of new and successful expression and purification protocols for diverse protein families and determination of their structures using X ray crystallography and Cryo EM o Molecular modelling of a type IV pilus protein , in collaboration with University of Turku Keywords : XFEL protein crystallography , X ray data collection , Cryo EM , structural biology , organization , scientific project management , Chimera , Pymol , Rosetta , Coot , Phenix , CCP4 . An EPFL graduate with a rich chemistry , biochemistry and biotechnology background developed through my academic studies in a number of leading institutions . Passionate about project and information management , biotechnological innovation , process development and optimisation , scientific research and writing . I am a fast learner who enjoys working in multicultural and international environments . I am motivated to improve my skills and experience to make transformative contributions in biotechnology and pharmaceutical industry . You are more than welcome to contact me if you have any questions and want to network .. Technologies : Xray;CryoEM",proteins;expression;structure
"Computational Genomics Research Scientist . . Recent Ph.D. graduate with experimental and computational biology expertise . Experienced in data analysis using R , Python , Linux , and cloud computing AWS , GCP . Proficient in next generation sequencing data analysis , statistical analyses , experimental design , and molecular biology techniques . Current research focused on the relationship between the human gut microbiome and type 2 diabetes . Strong communication skills with experience presenting research at various conferences and developing lasting collaborations among research groups . Self motivated and independent learner . Teamwork , leadership , and service experiences in numerous organizations .. Technologies :",
"Scientific Application and Lab System Support . Advanced Desktop System support for Structural and Computational Biology , Oncology , Cancer Biology , and other Research departments . Primary duties include ; Application support for scientific applications such as ACD Labs , MDL Suite , ChemOffice , Crossfire Commander , Gene Codes Sequencher , Graphpad Prism , Mattlab , Pharsight Winonlin , and Lasergene , IDBS Biobook , Spotfire Decision Site DXP , Accelrys Discovery Studio , NONMEM , IPA , SAS JMP , Partek Genonics Suite , and EndNote . Primary support for application compatibility and dependencies such as Java , Sassafras KeyServer , and MDL Chime Pro . Analyze problems routed to queue and escalate issues where normal processes are failing to deliver timely solutions . Liaised with customers throughout the life of the call , and ensured customer satisfaction before closing calls . Resolved problems personally wherever possible or coordinated support from other business technical training specialists to complete problem analysis . Ensured issues allocated to team by call centers , and customer requests are analyzed effectively . Owned tasks throughout their life cycle . Worked proactively with designated customers to ensure high awareness of support service availability capabilities . Developed , maintained , and applied the highest levels of customer care professionalism . Observed and assessed the effectiveness of customer use for applications and offer proactive support to increase customer comfort and expertise in using applications . . Microsoft Certified Systems Engineer with extensive knowledge of the management , support , and troubleshooting of various networked systems on a variety of Operating Systems including Windows 7 , Windows XP , Windows 2000 , Windows NT , Windows 95 , Windows 3X , Apple OS 9.x and OS X , Red Hat and SUSE Linux , Novell 4.x , and Altiris Deployment and Notification Servers . A Certified System Technician . Thorough knowledge and experience in supporting most widely used scientific applications . Working experience with laboratory systems such as Rockmaker , FloJo , and Tecel .. Technologies :",
"Associate Professor of Neurology and Biomedical Engineering w tenure . I lead the Laboratory of Brain eScience LoBeS , a team of researchers from a broad range of academic backgrounds to study brain structural variability and its associations with brain disorders . The team , funded through both federal and nonfederal grant support , includes experts in engineering , computer science , computational biology , population genetics , and neuroscience . We develop and use advanced computational and data science approaches to combine and analyze large scale databases of brain scans , alongside demographic , clinical and genomic data to : 1 chart the course of dynamic brain changes throughout life ; 2 understand the relative contributions of various risk factors for disorders ; and 3 predict brain functional related outcomes . We are now focusing our efforts on mapping aging trajectories in the brain across populations , and alterations associated with risk for Alzheimer and related dementias , Parkinson disease , and a wide spectrum of mental illnesses and common features , including suicide risk . The lab is focused on developing and using markers of brain structure , microstructure , and connectivity patterns to understand the biological and mechanistic underpinnings of brain function , and use these features in addition to common clinical features to predict outcomes in relation to brain health and disease progression . . . Technologies :",
"Scientist II , Computational Biology . . Computational Biologist with applied research experience in the biotech industry . Skilled in Data Science , Mathematical Modeling , and Bioinformatics . . Technologies :",
"Scientist Product Analytical Development . . Development of physicochemical methods in area of AAV based gene therapy . . Have a broad experience in creations and characterizations of liposomes with cytostatics . pH gradient methods for charged API , direct encapsulation for hydrophobic API . Work in aseptic conditions , in clean rooms . . Experience in analytical methods development and validation according to ICH requirements . . Expert in HPLC , GC , GC MS , TLC , AAS , IR , SDS PAAG Electrophoresis , in quality control and drug development . Ultrafiltration , size exclusion chromatography , freeze drying . . Multistep peptide synthesis in solution by Boc Bzl technique , purification methods column . chromatography , ion exchange chromatography , preparative HPLC . . Work in GMP environment in modern pharmaceutical manufacturing . Experience in analytical instrument qualification , process validation , cleaning validation . . Experience of handling and safety works with potent API . . Technologies :",carriers;characterization;developing
"Staff bioinformatics scientist . . Despite ongoing research , the causes of many genetic disorders remain challenging to determine , and each failed attempt at detecting mutations is potentially life threatening to patients . As a bioinformatics scientist with a focus in clinical diagnosis , having a background in biology , statistics and computer science helps me recognize the hidden issues of regular NGS analysis and devise appropriate solutions . Improving the accuracy of mutation detection is the long term primary goal of mine . Through collaboration with my colleagues , I have developed algorithms to detect difficult disease causing mutations , including mitochondrial deletion , large size insertion deletion , Alu element insertion , and STR expansion . A statistical model is also established to detect gene conversion and potential false positive false negative calls for clinically important genes under pseudogene influence . Applying NGS data to detect structural chromosomal abnormality is one of my main focuses since NGS data provides better resolution compared to aCGH . My current project focuses on extending the algorithm to detect gene fusion and translocation . Skills Proficient in Python , R , Linux shell script , PHP and SQL . Prior experience in MYSQL , C C , Matlab , Perl , and SAS . Hands on experience with large scale WGS , RNA seq and ChIP seq data . Solid understanding and excellent skills in algorithm optimization , statistical analysis , and machine learning methods .. Technologies :",
"Researcher Senior Software Developer . Fundamental bioinformatics research on human aging and cells differentiation https : research.jetbrains.org groups biolabs Aging project : joint research project of Healthy Aging with Washington University in St. Louis , USA Done part of Chip Seq data analysis and Genes Enrichment analysis Introduced and implemented overlap metric which is used for Chip Seq peak caller tunning in SPAN SPAN Semisupervised Peak Analyzer https : research.jetbrains.org groups biolabs tools span peak analyzer Peak caller for ChIP Seq , ULI Chip Seq , ATAC Seq Implemented overlap metric used for peak caller tuning JBR genome browser with peak calling functionality , multiple locations mode , and more https : research.jetbrains.org groups biolabs tools jbr genome browser Implemented core features e.g tracks rendering , UI , etc Implemented tracks for BigWig , Methylation , Bed files rendering SnakeCharm https : plugins.jetbrains.com plugin 11947 snakecharm : A plugin for PyCharm and other IntelliJ Platfrom IDEs that adds Snakemake language support as Python dialect . Snakemake is a framework which is widely used by researchers for reproducible data analysis pipelines development . Implemented most part of the plugin : parser , syntax highlighting , code completion resolve Supervise interns and manage development tasks Big https : github.com jetbrains research big I support and improve Kotlin library for Bigwig and Bigbed files read write Educational activities : lecturer and scientific advisor Snakemake mini course for ITMO master degree students 2020 Masters Degree dissertations supervisor 2019 System Biology Workshop lectures 2018 2019 . I 'm a researcher 7 , data analyst 5 years , and software engineer 15 years in a bioinformatics group at JetBrains Research . My main research interests are in the fields of human aging and human epigenetics . Also , I 'm interested in Deep Learning and develop IoT as hobby projects . My work related duties and activities are : I develop new software and algorithms , do bioinformatics research and data analysis , teach and mentor students , give lectures in summer schools and workshops on computational biology , give projects for internships , interview and supervise interns for my projects , collaborate with researchers from other Universities .. Technologies :",
"Senior Scientist . . I 'm a protein biochemist who is versatile in all ascpects of protein preparation , characterization and crystallization . I can rely on a broad methodical knowledge in protein analytics , molecular biology , cell culturing , or FPLC based purification . I 'm familar with prokaryotic and eukaroytic expression systems as well as a wide range of biophysical methods for protein characterization and was able to solve various protein structures in projects with different backgrounds . . Technologies :",proteins;characterization;expression;structure
"Scientist II , Computational Biology . . Computational biologist and bioinformatician with diverse academic and industry experience in genomics , genetics , and neuroscience , especially focused on RNA biology . he him his I 'm Alex , and I received my Ph.D. in spring 2019 from the Genomics and Computational Biology program at the University of Pennsylvania Perelman School of Medicine in Li San Wang 's lab , part of the department of Pathology and Laboratory Medicine and the Penn Neurodegeneration Genomics Center . My thesis research was focused on understanding how noncoding genetic variants regulate gene expression and modulate disease risk . To do this , I developed algorithms http : inferno.lisanwanglab.org to unbiasedly identify the regulatory mechanisms affected by noncoding genetic variants , the target genes and relevant tissue contexts of those regulatory mechanisms focusing on enhancers and small RNAs , and the ultimate downstream biological processes modulating disease risk . These bioinformatics methods are trait agnostic , but I applied them in the CNS space , mainly neurodegenerative diseases Alzheimer 's Disease and Progressive Supranuclear Palsy as well as psychiatric traits such as schizophrenia . I have extensive experience handling many flavors of large scale biological data including genomics , transcriptomics , epigenomics , and Hi C and developing software principally using Python , R tidyverse , and bash . I also have experience in wet lab techniques including molecular cloning , protein biochemistry , transient transfection , cell culture , and luciferase assays . My PhD thesis research yielded several first and middle author papers stemming from interactions with researchers both inside and outside of my thesis lab . My collaborative nature also allowed me to perform research in many exciting fields including computational biology , epi genetics , neuroscience , health economics , and molecular biology . Recent ish cv available : https : www.dropbox.com s b8zs69saam33c4o alexandre amlie wolf cv.public.pdf dl 0 ORCID page : https : orcid.org 0000 0002 2073 1519 Personal website : https : alexamlie.github.io . Technologies :",
"Team Leader , Reagents . . Highly skilled , dedicated and successful pharmaceutical scientific professional with over 20 years of experience as a bench scientist in the fields of GPCR and Membrane Biochemistry Biophysics . Career as a scientific researcher has focused primary on the multifaceted therapeutic areas of pain , hypertension and immunology . Significant and effective contributor to productive Ion Channels and Pharmacology departments ; known by colleagues for being meticulous , and act with impeccable integrity . Expertise include developing , implementing and troubleshooting high quality , robust and reproducible in vitro and cell based biochemical functional assays for target engagement , profiling and high throughput assays . Interested in validation of new drug targets , discovery of novel therapeutics for major unmet medical needs and contributing to the development of new chemical entities using state of the art technologies .. Technologies :",membrane proteins;small molecules;interaction;screening
"CTO . Biosimilar development . Construct design , strain optimization , fermentation , mid stream process optimization , purification , formulation , up scaling , tech transfer , regulatory issues , EMA briefing book etc . Research interests : Over expression of proteins in Gram negative bacteria , especially proteins used in the pharmaceutical industry . Optimizing the expression of proteins in Gram negative bacteria . Process optimization Upstream processing Strain engineering Plasmid engineering development Growth and induction regimes Downstream processing Harvest and recovery Periplasmic release Purification Formulation Other merits of relevance Speaker in two sessions , Peptalk USA 2016 . Biosimilars Development conference Germany 2016 . PEGS protein engineering summit USA 2015 . BIO International convention USA 2015 . Speaker at PepTalk USA 2015 . CPHI worldwide convention Spain 2015 BIO International convention USA 2014 . PEGS Europe , Portugal 2014 . PEGS protein engineering summit USA 2014 . Protein Society Conference IX European Symposium Sweden , 2011 . Speaker at the FEBS conference Molecules of Life Sweden 2010 . EMBO Conference Regulation of Protein Targeting and Translocation France 2008 . Course EMBO Molecular and Cellular Biology of Membranes France 2007 Workshop EMBO New Methods in Membrane Protein Research Sweden 2007 ASM FEMS Conference Protein Traffic in Prokaryotes Greece 2006 . Course Biochemistry and Biophysics of Membranes Sweden 2006 Course Membrane Protein Preparation Sweden 2006 Course EMBO Young Investigator Germany 2005 Synopsis of publication record 1 Article in review . 14 original scientific publications in peer reviewed journals . 1 book chapter Methods in Molecular Biology 2010 . 1 book chapter in review Methods in Molecular Biology . 1 application note NEB . . Technologies :",biologics;developing;formulation
"Research Scientist at EMBL . My actual main focus is the the structure determination by SPA cryo EM of small protein complexes 80 150 KDa . Samples are prepared by collaborators , which work in the Grenoble area EMBL , IBS , LPVC , IAB . Importantly , I combine each scientific project with cryo EM training grids preparation , screening and data collection , processing . In the period 2018 2020 , I 've actively participated to the management of the EMBL Grenoble Electron Microscopy internal platform . Structural biologist in the field of host pathogen interaction with longstanding experience in molecular biology , biochemistry and X ray crystallography and SPA cryo EM experience .. Technologies : Xray;CryoEM",proteins;structure
"Senior Analytical Scientist . . Expert in analytical chemistry , membrane protein biochemistry and bioinorganic chemistry research . Method development and validation . Coordination , planning and execution of multiple research projects .. Technologies :",
"Bioinformatic Scientist in the Bioinformatics Core . . Life Science skills Skilled in statistics : basic probability , densities , distributions , sampling distributions , mean , variance , and covariance Dynamic Modeling : matrix models , differential equations , complex dynamics understanding models , assumptions , and implications DNA Sequence chromatogram assembly and error correction : Phred , Phrap , Consed , Chromas , staden package Pregap , Gap , Spin , Illumina Genome Analyzer Pipeline , MAQ , Bowtie cufflinks suite , Trinity , samtools , PicardTools , GATK , velvet , BLASR , Falcon Unzip , HGAP , and BWA . Nucleotide and protein sequence alignment analysis and annotation coding regions , transposable elements , splice junctions , etc : T Coffee , Dotter , RepeatMasker , BLAST and its derivatives BLASTX , BLASTP , etc . Understand the principles behind maximum likelihood estimation of phylogeny , Bayesian inference , hidden Markov models , bootstrapping , and model selection , adequacy , and averaging . Skilled in using the following for phylogenetic analysis : BayesTraits , Mega 4 , DNASP , Tassel , Mapmaker , and QTL Cartographer . Experience with using NGS big data on computational clusters to create production pipelines Computer Technical skills MS Office Suite : Word , Excel , Access , PowerPoint , Visio Proficient in configuring many types of network infrastructures to include Unix , Windows , and Mac Proficient with Python , Perl , Java , Javascript , SQL , and Shell programming and skilled with C , C , VBS , and R languages Proficient in creating webpages for operational support and using web traffic for data analytics Project Management Communication Skills Experienced in overseeing resources , time , and budget Experienced in delegating tasks to other colleagues Effective verbal communication and Strong written skills . Technologies :",
"Senior Research Scientist . 634.01 Peptide Characterization , Diabetes . Specialties : Expertise in : Protein stability , protein folding , protein aggregation , membrane proteins , protein detergent interactions , ligand binding , protein electrostatics , development of HPLC analyses Techniques : CD , fluorescence , DSC , ITC , AUC , SE HPLC , RP HPLC , HIC , DLS , CG MALS . Technologies : ITC;SLS DLS;DSC;AUC",membrane proteins;peptides;characterization;interaction;stability
"Senior Scientist Principal Investigator . New main responsibility for scientific projects at Nanion in the field of membrane transporters , both in house and customer related . Principal Investigator within the NeuroTrans program funded by the European Commission s Horizon 2020 framework . . Motivated PhD level biochemist working at Nanion Technologies Munich , since 2016 . Responsible for R D using the SURFE2R technology . Research projects , product development , marketing , sales and customer support . PhD at the Max Planck Institute of Biophysics Frankfurt , 2011 2016 . Started working on membrane transporters using electrophysiology , fluorescence and radioactive transport assays . Studied biochemistry at the Goethe University Frankfurt , 2005 2011 . Well trained in biophysical techniques , protein science , molecular and cell biology . High level of project management experience Frankfurt , 2008 2012 . Raised six figure sum by writing grant proposals . Initiated and supervised scientific projects , eLearning and teaching activities . . Technologies : Xray",
"PhD Molecular Biology Biochemistry . Versatile PhD with experience in both fundamental and applied research ; strong background in biochemistry molecular biology , with emphasis on enzymology and microbial biotechnology . Expertise in diverse scientific topics , including cytochrome P450 monooxygenase based biocatalysis , Nisin and Hemolysin A biogenesis , bacterial multi drug resistance , protein folding and protein secretion . . . Technologies :",enzymes;proteins;stability
"Senior Manager . . Research and development manager with nineteen years of experience from industrial R D , spanning product and business development , project and line management , pharmaceutical formulation and device research , pre formulation , analytical development , biophysics , instrument construction and process analytical technology . I have a positive leadership style where involvement , empowerment and coaching create the foundation for motivation and a good working environment . I thrive working in explorative project phases , across cultures and borders . I motivate my team to high engagement and delivery of both short and long term goals . I am open minded , have a clear communication and find stakeholder management at all levels a central part of my work . I am detail oriented and ensure business critical goals are met in time and quality . Key competencies : Management : People leadership , project management , team organisation , cross functional and external collaborations , competency development , strategic planning , lean product development . Scientific : Materials science , device drug product research , solid and liquid pharmaceutical formulations , pre formulation , physico chemical and molecular properties , molecular spectroscopy , chemometrics , computational chemistry .. Technologies :",formulation
"Computational Biology Data Science Director . . Dave is a senior technical leader and manager with more than 35 years of experience , emphasizing research and development as well as software medical device development in biotechnology and pharmaceutical industries and national laboratories . Currently he is the technical lead for an advanced development program at Amgen to explore medical devices built on mathematical modeling and simulation of human physiology . Previously , Dave was Amgen s Vice President of Research Development Informatics . Prior to joining Amgen , Dave was CIO and Vice President of Informatics and Information Technology at Signature Bioscience in San Francisco . Dave has also held positions with Affymetrix , Inc. , Sterling Winthrop , Inc. , Lawrence Berkeley National Lab , and Lawrence Livermore National Lab . Dave holds a Ph.D. in Applied Mathematics from the University of California Berkeley . Throughout his 35 year career , Dave has been awarded more than 15 patents in the field of database design and data visualizing techniques and has a similar number of patent applications pending . His technical interests include functional programming , formal specifications for scientific models and simulations , and the application of mathematical systems theory to biology , medicine , and drug discovery . Dave is a Fellow of the American Mathematical Society and a member of the Board of Trustees of the Institute for Pure and Applied Mathematics at the University of California Los Angeles . Dave has served as a grant proposal reviewer for the Physical Sciences Oncology branch of the NIH . . Technologies :",
"Associate Researcher , CHS Research Group Noroviruses . Characterization of Nanobodies Norovirus interaction by cryo electron microscopy and X ray crystallography to provide specific diagnostic tools . Supervisor : Dr. G. Hansman . Structural biology is amazing , the graphic beauty of protein assemblies highlights the genius design of Nature . For my part , the knowledge of protein mechanism offers me the possibility to design diagnostic and therapeutic tools . That 's the attractive challenge My experience first focused on the interaction mechanisms between a bacterial lectin and several ligands in order to design anti adhesion compounds useful as an alternative to antibiotics for cystic fibrosis patients carrying bacterial infections . Since then , I keep interest in host pathogen recognition , especially those involving glycan moieties . Being familiar with synchrotron beamline data collection , phasing methods MR , SAD , MAD , MIR and structure refinement , I like taking advantages of crossed approaches like thermodynamic and inhibition tests on microplates in the Structure Based Drug Design . The exploration of viruses and immune response during my postdoctoral research HIV , Kobuvirus , Rotavirus , Norovirus , gave me skills in molecular biology and biochemistry . To understand large particle assembly icosahedral capsid microtubules , it is necessary to carry out mammalian cells culture , samples purification , cryo EM data collection , single particle reconstruction and analysis of results . Solving this puzzle is fun . Technologies : Xray;CryoEM",antibodies;small molecules;interaction;structure
"Professor . Biochemistry , Protein structure , X ray crystallography , Protein purification , Biophysics . Research Interests : Structural biology , X ray crystallography , biophysical characterization of the signaling components of the visual signal transduction pathway , protein ligand interactions using SH3 domain containing proteins , blue light photoreceptors of the LOV family , natively unfolded proteins , protein aggregation using dynamic light scattering and CD spectroscopy . Experimental approach : The primary focus of my research is to understand the structure function relationships of soluble and membrane proteins of biological importance . My approach is to conduct these studies with techniques that allow a complete dissection of kinetic and structural properties of the proteins in static and dynamic states . The functional and thermodynamic properties on wild type and modified forms of the macromolecules generated by site directed mutagenesis are studied extensively using transient and steady state kinetics , as well as selected biophysical techniques . The functional information is then combined with the three dimensional structure determined by X ray crystallographic techniques . https : www.uni duesseldorf.de MathNat ipb index.php index 1338 detail 131 . Technologies : Xray;SLS DLS",proteins;small molecules;characterization;expression;interaction;stability;structure
"Tenure Track Professor . Faculty member and Principal Investigator in the College of Biological Sciences , Department of Plant Biology , UC Davis . My research group aims to unravel the biological mechanisms controlling fundamental signaling pathways using diverse interdisciplinary approaches including structural biology X ray crystallography and Cryo EM , biochemistry , molecular and cell biology in plant , fungi and mammalian systems . . Dr. Nitzan Shabek is a Tenure Track Professor and a Principal Investigator at the University of California , Davis . He is also a member of the Scientific Advisory Board of OerthBio LLC an agricultural biotech company and a joint venture between Bayer and Arvinas . His research group at UC Davis integrates cutting edge approaches from the fields of structural biology , biochemistry , molecular biology , and plant biology to elucidate signal transduction pathways and revealing their regulation by the Ubiquitin Proteasome System . His laboratory also addresses pathophysiological challenges through innovative bio engineering synthetic biology strategies . He received several distinct awards including the UC Davis Award for Innovation and Creativity , the National Science Foundation NSF CAREER Award , and the 2021 Neish Award . As a faculty member at UC Davis College of Biological Sciences , Prof. Shabek has been teaching Biochemistry classes as well as developing new educational approaches via Virtual Reality .. Technologies : Xray;CryoEM",molecular glues;proteins;structure
Researcher PHD Student . Cryo electron microscopy at the Beckmann Lab . . Technologies : CryoEM,structure
"Senior Principal Scientist . Structural Biology , Cryo EM , Drug Discovery . I am passioned about patient centered drug discovery and optimizations . Teamwork , good science , and strong data are the pillars of my work . I enjoy collaborating and applying new techniques towards personalized drug discovery . Mentoring and teaching has been central to my work . Skills Extensive experience in CryoEM , Membrane biology and Team leadership . Technologies : CryoEM",membrane proteins;structure
"Associate Director , Computational Chemistry . . I m a computational chemist with a foundation of knowledge in chemistry and biology , and a passion for drug design . In close collaboration with discovery and preclinical colleagues , I lead a group that focuses on designing , investigating , prioritizing and optimizing potential therapeutics with structure based , ligand based and informatics techniques .. Technologies :",
"Statistician President . Statistical and machine learning consulting . We bring together teams of focused analysts and engineers to solve your data needs . Medical Clinical trials , Design of experiments , ... Internet Multivariate A B testing , User attrition modeling , Click optimization , ... Industrial Streaming sensor data , Failure prediction , Equipment optimization , ... Analytics Classification , Neural Networks , Prediction , Survival analysis , Unsupervised methods , Visualization Design ... Languages R , Python , Java , C , SQL Big Data Spark , HBase , Cassandra , MapReduce , Scalable algorithms . Dr. Ian Fellows is a statistician and data scientist with research interests in the intersection of mathematical statistics and computer science . He has authored 24 papers and delved deeply into many sub disciplines including artificial intelligence , where in 2007 08 his Texas Hold em AI programs were ranked second in the world . In machine learning , his contributions to modeling social networks using exponential family models have found applications in disease modeling . He is also the primary author of the open source Deducer suite of packages , which provide an easy to use graphical interface to the programming language R. His work in designing Deducer s statistical visualization interfaces won the prestigious John Chambers award . Ian has held research appointments at UCLA and UCSD , as well as the position of Chief Scientist at Osprey Data , where he lead the data science team in building scalable algorithms and infrastructure for near real time analytics on sensor data . Since 2009 his analytics consulting company has had a proven track record of bringing data science teams together to solve big data problems for a diverse range of corporate clients in fields such as education , internet marketing , and statistical software development . Visit http : www.fellstat.com for more information . Technologies :",
"Senior Research Scientist . Injectable Formulation Research . Professional Profile A highly motivated multidisciplinary scientist who thrives on working with people and executing complex projects . Research and project management skills gained from working in internationally renowned centres across Europe : GSK London , MRC London , CNIO Madrid , NNF CPR DK , NN DK . My strength lies in my passion for scientific curiosity and engagement with focus on people and progress . Striving towards expanding and strengthening business understanding , shaping strategic discussions , creating organisational value and personal growth . Novo Nordisk valuable insight gained from working across R D from pre projects to G1 passage . As a formulation scientist my role includes biophysical characterisation of target products ; design short long term stability studies ; compare bi functional and co formulation studies and deliver on projects ranging from peptides to antibodies . As a drug product co ordinator , lead timely handover and technology transfer to CMC . Innovation projects allowed portfolio strategy and stakeholder management followed by driving facilitating the project across R D. Executive Management Program at IE Business school Building A Start Up : From Bench to Market . Artist oil painting and co owner of Gallery Bopa . . Technologies :",antibodies;peptides;characterization;formulation;stability
"Director , QARA Data Analytics . Lead data scientists , BI analysts and statistician to support dashboard reports , data analytics and visualization and statistical services under quality and regulatory fields . . Senior information centric expert with 10 years of advanced data strategy and analytics skills developed through both industry and academia Enriched experience of working under highly regulated environment in MedTech Pharma companies Master of Data Speaks philosophy interrogating data to generate meaningful outputs to assist decision making Certified training on leadership and management skills through world prestigious trainer Wilson Learning and Development Dimensions International . Expertise in managing multiple projects and collaboration with internal and external stakeholders by excellent communication Solid statistical knowledge and efficient computer programming Publication records of over 30 peer reviewed journal articles , along with 50 conference abstracts . Technologies :",
"Postdoctoral Researcher . . I am a postdoctoral fellow at EMBL Grenoble October 2019 present . I have recently been awarded a Marie Sk odowska Curie individual fellowship to research influenza virus transcription , primarily utilising protein production from mammalian cells and cryo electron microscopy . Previously , I completed my D.Phil in clinical medicine at the University of Oxford between October 2015 December 2019 . The focus of my research was to understand the receptor binding protein structure and biology of emerging paramyxoviruses . Prior to my doctoral work , , I was awarded a 1st for my Bsc in Microbiology with Virology Industry at the University of Leeds . During my undergraduate studies I worked at Biopharm Innovation Domantis GSK , Cambridge , as an industrial placement intern between July 2013 June 2014 .. Technologies : CryoEM",proteins;interaction;structure
"Application Scientist . . Single particle cryoEM expert with 11 years of experience building and maintaining cryoEM labs collaborating with hundreds of researchers and thousands of samples across three major universities to determine the structure of macromolecular complexes leading to 17 co authored papers from viruses to membrane proteins . In addition the hands on EM data collection and sample preparation , I provide feedback on experiments involving cryoEM and its potential possibilities and limitations in answering biological questions . I maintain an electronic database of images cross referenced by experiment . Provide images and language suitable for grants and publications . Educate through hands on and in lecture environments both EM fundamentals and specialized techniques . Skills : Sample preparation for Cryo EM , negative staining in solution , SEM , image analysis , tomography utilizing SerialEM , and 3D particle reconstructions . Equipment : Titan Krios , Talos Artica , Gatan K2 BioQuantuum , Vitrobot , JEOL 2100 200kV Cryo equipped Lab6 TEM with Ultrascan 4000 CCD for high resolution single particle data acquisition , JEOL 1400 120kV , Gatan CP3 , and a wet lab with centrifuge and ancillary sample prep equipment . . Technologies : CryoEM",
"Director CMC Protein Development . . 10 years industry experience in biologics development expert for cell line development engineering advancing coagulation factors , mAbs , VHH formats and AAV vectors from lead discovery to clinics . Technologies :",antibodies;carriers;structure
"Doctoral Student . Computational Method Development , Automatic Protein Structure Modelling , Teaching and Supervision of Students , Presenting Results at International Scientific Conferences . Computational method developer with a passion to solve problems and unravel puzzles of all kinds . After thinking a lot about elementary particles and fields during my bachelor 's degree , I changed directions . In my master 's thesis I sought to deepen my understanding of the human brain by analysing images acquired by diffusion weighted MRI . Precisely , I introduced a new measure to quantify structural connectivity between brain regions . At the moment I am doing my PhD in the field of computational Biophysics . My field of interest are now proteins , so called building blocks of life . I work with data acquired by cryo electron microscopy . My aim is , to develop software facilitating the analysis of these data , i.e. reconstructing the atomic structure of the examined proteins .. Technologies : CryoEM",
Principal Scientist . . I am a research scientist that does biological modelling and simulations . My research focuses on applying state of the art modelling techniques to study complex biological systems . . Technologies :,
Snr Postdoctoral Researcher . . Current research at University of Hull is the optimization of deep learning architectures for time series classification . Technologies :,
"Senior Algorithm Scientist . I am now focusing on camera algorithms R D , including computational photography , image processing and machine learning . . Experienced engineer scientist with a demonstrated history of working in the industry and higher education . Skilled in computer vision image processing , machine learning , secure computing , and cryptography . Strong research professional with a Doctor of Philosophy Ph.D. focused in Electrical and Computer Engineering from University of Oklahoma .. Technologies :",
"Scientific Associate DNA Encoded Library Screening DEL . Transfer of a novel technology called DNA encoded library screening DEL from an external biotechnology company onto a new established team and laboratory . Establishing of the whole DEL process to the Novartis environment . Continuous optimization of the selection screening method and data analyzing process . Assay development and screening of NIBR projects with the DEL technology . Key contact to provide biological and biochemical expertise and support to the library production teams . Follow up screening of selected compounds with biochemical assays . Planning of experiments , compiling of data , interpreting of results and communication presenting to . direct supervisor and project teams . Documentation in laboratory ebooks and establishing SOPs reports . 3 . 5 months internal sabbatical in chromatin profiling group CCB to learn technics like ChIP . Seq ChIP qPCR and chromosome conformation capture 4C technology . . Research Laboratory Scientist with experience in biological , biochemical and analytical laboratories . Knowledge from over 10 years in pharmaceutical industry . Proven experiences in planning , executing and analyzing independently experiments . Excellent in problem solving , outstanding organizational skills , providing high quality within given timelines and good communication skills . Extensive experience writing research reports and protocols . Active team player who fosters collaboration . Expertise includes : . DNA encoded library screening Drug target discovery and validation by biochemical and cellular assay development with high throughput screening and compound profiling Data analysis using different tools , e. g. Spotfire Enzymology Biophysics Molecular biology Epigenetics RNA interference . . Technologies :",small molecules;screening
"Senior Computational Biologist . . I am passionate about extracting knowledge from data using the best tools I can get my hands on . The question is always the most important component of data science . Therefore I strive to adapt my skills to the most efficient ways for getting the information required , even if that involves learning whole new set of skills . That said , I am obsessed with innovation and committed to a lifelong learning . We live in a very exciting time where we have free access to unprecedented volume of high quality information so I am constantly trying improve myself as a professional and as person .. Technologies :",
"Senior Scientist Mathematical Modeler . . My specialization exists at the interface between dry and wet lab approaches . I enjoy strategizing how to model complex phenomena based on the goal , the data , and the unavoidable assumptions . I 'm particularly fascinated with dynamical systems . I am a PhD level computational biologist with 8 years of academic research . I am passionate building and comparing predictive models trained on biological data . Highly knowledgeable in different forms of machine learning , python , and MAPK signaling biology . I love mentoring and collaborating When I 'm not at my computer , I go rock climbing , mountain biking , and backpacking .. Technologies :",
"Scientist . Antibody production , analysis , and engineering . . Technologies :",antibodies;characterization;engineering
"Researcher . Researcher and supervisor for electrophysiology , molecular biology , protein biochemistry , and molecular dynamics experiments to elucidate structure and function of membrane proteins relevant to human drug use and drug design . . I am a biochemist studying the molecular interactions between brain proteins and drugs that alter behavior and experience .. Technologies :",membrane proteins;proteins;interaction;structure
"Graduate Research Assistant . Graduate research and teaching assistant in the Department of Molecular Biosciences , advised by Dr. Arlen Johnson and Dr. David Taylor . Investigating the structures of intermediates of ribosome biogenesis , using yeast genetics and cryo electron microscopy . . . Technologies : CryoEM",proteins;structure
"Principle Computer Biologist . The HAVANA team carry out the manual analysis and annotation of vertebrate genome sequences , and generate the GENCODE geneset for the human ENCODE project . I play a key role in both the planning and implementation of our scientific strategy , and manage 7 members of staff . My recent achievements include : Developing pipelines for the integration of next generation datasets into gene annotation , including RNAseq , CAGE , ribosome profiling , mass spectrometry . Working to improve the usablity of our resources , in particular to help distinguish and understand functional transcription events . Promoting our resources at international meetings , presenting at conferences including ASHG , Genome Informatics , HGM , SMBE and AGBT . Detailing our work in several high impact publications , listed below . Coordinating our annotation with the ongoing efforts of the Genome Reference Consortium . Reaching out to other communities to show how we can aid them . In particular , I am now working with disease biologists and clinicians on the interpretation of variation linked to specific diseases . Organising and running workshops , for example a 2 day meeting focusing on protegenomics . Publications as first author : Improving GENCODE reference gene annotation using a high stringency proteogenomics workflow . Nat Commun . 2016 Creating reference gene annotation for the mouse C57BL6 J genome assembly . Mamm Genome . 2015 Functional transcriptomics in the post ENCODE era . Genome Res . 2013 The origins , evolution , and functional potential of alternative splicing in vertebrates . Mol Biol Evol . 2011 Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice . Genome Biol . 2008 Evolutionary implications of pericentromeric gene expression in humans . Cytogenet Genome Res . 2005 Neocentromeres in 15q24 26 map to duplicons which flanked an ancestral centromere in 15q25 . Genome Res . 2003 . I am a genome scientist , specifically a Principle Computer Biologist and manager at the Wellcome Trust Sanger Institute . My field of work concerns the study of the human transcriptome , and I have made significant contributions to the GENCODE and ENCODE projects . My particular interest is the function and evolution of transcriptional complexity , and I am now developing these ideas in the field of variation analysis . Specifically , I wish to understand how variation interpretation can be confounded by the existence of transcriptional complexity . I am also working on the development of proteogenomics methodologies to aid gene discovery , as well as the integration of novel datasets such as RNAseq and Hi C into annotation workflows . . Technologies :",
"Co Director . . I 'm a group leader of the Analysis , Visualisation and Informatics AVI group at Oxford University working on new ways to analyse and integrate biological research and clinical data . We 're developing new ways of visualising massive multi dimensional data sets using techniques from machine learning to immersive technologies such as virtual reality . My current areas of research include spatial proteomics , multiplex imaging , epigenetics and 3D genome modelling . My key areas of interest are developing software that allow scientists to get insight from the ever increasing amounts of data being generated in biomedicine . I am especially interested in visualisation and using supervised and unsupervised deep learning techniques on large datasets combined with easy to use interfaces to augment human intelligence . This has led to me setting up an Oxford spin out software visualisation company called Zegami . My latest research interest is spatial computing and we are developing applications in Virtual and Augmented Reality in the medical space . I 've been programming computers since the early 1980s and have loved biology from an early age . I got a microscope as a Christmas present when I was 9 and used to spend hours looking at biological specimens under it . Being able to combine computers and biology as a career is a dream come true As as result I studied a Microbiology BSc and then Computer Science MSc and got my first job working at Glaxo now GlaxoSmithkline to work on the ' new ' and exciting field of bioinformatics . I learnt so much there about bioinformatics and working in industry and after a few years decided to work at a bioinformatics start up in Australia . I made the decision to come back and work in the UK for an SME managing a proteomics bioinformatics group but wanted to get hands on again . As a result I moved to academia and set up a bioinformatics core facility at Oxford University . Working at Oxford University and developing your own research ideas is an amazing opportunity and am privileged to work with world class scientists and cutting edge techniques and equipment . I manage a team who are great mix of talented researchers and students .. Technologies :",
"BIOVIA Lead Scientist . . Computational chemist with many years experience of applying modelling informatics solutions in a drug discovery environment . Specialties : cheminformatics , structure based design , fragment based design . Technologies :",
"Specialist , CMC and Formulation . Translating AI generated insights into tangible medicines for patients in a truly agile organisation Formulation and CMC for personalised cancer immunotherapy and novel vaccines Analytical strategy , development and qualification Formulation of proteins , nucleic acids and adjuvants Collaboration with CROs CDMOs Stability studies Batch record reviews , OOS , root cause investigations , trouble shooting and problem solving . Pharmacist and PhD in chemistry with interdisciplinary knowledge and experience within proteins , peptides , nucleic acids , nanoparticles , polymer analysis and injection devices . 10 years of industrial experience at the interface of formulation , analytics and CMC , setting and executing analytical and formulation strategies . Drawing on my broad scientific experience , I am bridging disciplines and people to create world class solutions that drive projects . Key competencies : Analytical chemistry , biophysics , nanoparticles , formulation and CMC Respectful and assertive approach to people and projects Advanced problem solving and coordination skills Efficient communicator for multiple audiences Strong cooperation and networking skills across disciplines and cultures Hands on , resilient , and agile in my approach to work , I have contributed to multiple projects and innovations in pharmaceutical research and development and mentored several technicians , MSc and PhD students . I engage and build trustful and productive relations across disciplines and cultures through quality , integrity and transparency in everything I do . I listen to learn . I start with the end in mind and strive to create win win solutions for all stakeholders . I build bridges between people and disciplines . I deliver . I innovate .. Technologies :",biologics;nucleic acids;proteins;formulation;stability
"Postdoctoral Researcher . At the Center for Alzheimer s and Neurodegenerative Diseases , I focus on understanding and unraveling novel molecular mechanisms of protein aggregation in situ associated with neurodegenerative diseases using cryo correlative light electron microscopy cryo CLEM , cryo electron microscopy tomography cryo EM ET , and integrative modeling . . As a scientist , I am inspired to understand the biological mechanisms of neurodegenerative diseases at the cellular and molecular level for the purpose of therapeutic interventions . I have 12 years of solid research experience in industry and academia altogether . I am an independent researcher , and flexible to challenging and demanding atmosphere . Driven by curiosity , I want to dedicate my scientific career to translate the knowledge gained by basic research into potential therapy for neurodegenerative diseases .. Technologies : CryoEM",idps;structure
"Senior Scientist . Inhalation Product Development . Expertise in biophysical chemistry , protein technology and analytical chemistry .. Technologies :",
"Senior Bioinformatics Software Engineer . . Experienced Staff Scientist with a demonstrated history of working in the higher education industry . Skilled in Computer Science , Molecular Biology , Biotechnology , Java , and Biomedical Engineering . Strong research professional with a Doctor of Philosophy Ph.D. focused in Biomedical Informatics from Stanford University . . Technologies :",
"Scientist . . Graduate researcher with a demonstrated history of working in the higher education industry . Skilled in Molecular Biology , Cell Culture , Data Analysis , Protein Purification , Crystallization , and Cryo Electron Microscopy . Strong work ethic and education from Arizona State University . . Technologies : CryoEM",proteins;structure
"Medical Assessor Medicinsk utredare . . I have a long and solid research experience in Biochemistry , Biophysics and Structural Biology for studying Molecular Enzymology , Signaling and for development of potent and selective enzyme inhibitors . . Technologies :",enzymes;characterization;structure
"Scientist II . . Protein scientist Experienced in recombinant protein design , expression e. coli , insect Baculovirus , mammalian BacMam , transient transfection , purification and characterization for : Structural studies with X ray crystallography and Cryo EM Antibody discovery campaigns hybridoma and phage display Experienced in protein expression construct design for increased protein solubility and stability . Experienced in developing functional assays for validating protein reagents . Specialized in Automated High throughput technologies for : Baculovirus production Protein expression in E. coli , insect , and mammalian cells in miniaturized formats Antibody purification Purification optimizations of intracellular , transmembrane , and extracellular proteins Work Authorizations in : USA Greencard holder Canada Canadian Citizen Japan Special Permanent Resident . Technologies : Xray;CryoEM",antibodies;proteins;characterization;developing;expression;interaction;structure
"Senior Research Scientist . Senior Scientist , Oncology Safety Sciences , Oncology R D. . Build a platform with gastrointestinal GI organoids to investigate drug induced GI toxicity : . 1 . Assessing and predicting GI toxicity of the project compounds such as small molecule inhibitors , PROTAC and biologics such as Antibody Drug Conjugates , i. e. , ADCs with cytotoxicity assays on 3D intestinal organoids . . 2 . In vivo clinical adverse events to in vitro preclinical assays back translation assessment . 3 . Cross species translation assessment with intestinal organoids from species including mouse , rat , dog , and human . 4 . Genetic modifications with CRISPR Cas9 on GI organoids to support on off target assessment and mechanism of actions MoA studies . 5 . WB , Q PCR , flow cytometry with intestinal organoids to support MoA studies . Develop in vitro assays to study drug induced skeletal muscle toxicity : . 1 . Established rat L6 , and rat human primary skeletal muscle cell cultures myoblasts and myotubes in house . 2 . Set up cytotoxicity assays with skeletal muscle cells to predict drug induced skeletal muscle toxicity . 3 . Lauched lysate based and cell based biochemical assays to quantify activities of relevant enzymes in rat skeletal muscle cells . . Scientist with a strong background in cellular molecular biology , RNA biology , and toxicology .. Technologies :",antibodies;molecular glues;nucleic acids;small molecules;characterization
"Sr . Data Scientist . . Data Scientist with experience in generative deep learning models like Variational Autoencoders , anomaly detection for cybersecurity , and NLP using pre trained language models and LSTMs , among other projects . I have a keen interest in leveraging digital transformation to conceive novel use cases and applying machine learning methods to provide data driven solutions and actionable insights . My past work has also involved assembling parasite genomes from short reads and building 3D models of protein molecules using X ray crystallography and cryo EM .. Technologies : Xray;CryoEM",
"Research Associate . . Multi disciplinary scientist with a strong background and extensive experience in molecular biology , biochemistry , nucleic acid and protein chemistry , protein purification , enzyme kinetics , X ray crystallography and cryo EM single particle reconstitution . Vast knowledge in DNA repair , nonhomologous DNA end joining NHEJ , V D J recombination , severe combined immunodeficiency SCID , cancer , autoimmune diseases and bacterial glycogen starch synthesis . Worked independently and collaboratively with multidisciplinary teams . Assisted CROs in a NExT drug discovery project . Outstanding work ethic , detail oriented , strong leadership , communication , training and troubleshooting skills .. Technologies : Xray;CryoEM",proteins;structure
"Formulation Scientist . . I am a recent MSc graduate in Pharmaceutical Sciences , honored with the H.C. rsted Medal for graduating with excellence , and I am very enthusiastic about working with R D and production of biological therapeutics . I have a broad pharmaceutical background that I successfully applied for CMC development of peptide injectables and research in oral delivery of biopharmaceuticals . I have had analytical formulation product responsibilities and gained core competencies within peptide characterization , method development , HPLC and biophysics . I got a valuable insight into product development , manufacturing processes and regulations , which enables me to prepare protocols , design stability studies DoE , execute experiments , review documentation , and ensure pharmacopoeia compliance in a GXP regulated environment . As a person , I am curious , quality minded and a fast learner with a strong work ethic and analytical sense . I enjoy team collaboration with the focus on the common goal , and I value contributing to a positive working environment through a helpful and friendly attitude .. Technologies :",biologics;peptides;characterization;formulation
PHD Fellow . . I am a biotechnologist with specialisation in cell and molecular biotechnology and graduated in MSc Pharmaceutical Sciences . I have hands on experience in both in vitro and in vivo methodologies and I am currently working with cryo electron microscopy analysing protein structure and function . Check my latest paper on the structure and function of stator units of the bacterial flagellar motor : https : www.cell.com cell fulltext S0092 8674 20 31007 2 . Technologies : CryoEM,proteins;structure
"Research Assistant . The del M rmol lab studies the molecular mechanisms of sensory transduction , seeking to understand how animals detect the physical and chemical cues from their environment and transform them into cellular signals . In particular , we focus on the sense of smell in insect vectors of disease . In the del M rmol lab , we use cryo electron microscopy and a variety of biochemical , electrophysiological , and functional assays to dissect the structure and function of insect olfactory receptors involved in the detection of complex odors . . I received my Biology degree at the University of Texas with High Honors . I am now working at Harvard Medical School as a research assistant , studying the molecular aspects of olfactory reception in mosquitos . My long term goals include graduate medical education in order to determine how my love for molecular biology can compliment my interest in procedural medicine , orthopaedics , and orthobiologics . . Technologies : CryoEM",proteins;structure
"Director , Head of Therapeutic Oncology Research bei Nuvisan group . . Specialities : Drug Discovery , Project Managment , Preclinical Pharmacology , Target Validation , Chemical Biology , Lead Optimization , Epigenetics . Technologies : ITC;SPR",nucleic acids;proteins;small molecules;screening
"Head of Research Division of Computational Biology . The Division of Computational Biology brings together scientists with skills in developing and applying computational , mathematical and biophysical techniques to questions in biological and medical research . Members of the division either have their own wet lab or collaborate closely with wet lab experimentalists or clinicians to extract maximum value from experimental data that informs the development of predictive algorithms and models that may be tested experimentally . The Division shares a vision of Computational Biology as the focal point for the convergence of computing , mathematics and the physical sciences with experimental biology . The Division occupies one floor of the Discovery Centre building which is physically linked to the rest of the School of Life Sciences research complex MSI , WT and JBC buildings . We are actively seeking to make new group leader appointments in the Division . Address informal enquiries to Geoff Barton . For more information on current members of Computational Biology see : http : www.lifesci.dundee.ac.uk research cb . . Technologies :",
"Associate Professor . Organizer of International Scientific Meetings : Coorganizer of IUPHAR Teaching Section in Copenhagen , Denmark : Pre Conference Satellite Meeting to WorldPharma2010 , Faculty of Pharmaceutical Sciences , University of Copenhagen , 17 . 18 . juli 2010 . Departmental responsibilities were related to coordination of teaching activities , proper scheduling of different departmental courses during the semester , providing advise on the content of courses as well as on creating new courses when necessary , and finally evaluation of the courses in order to ensure that the department is capable of providing the students with good quality , attractive and coherent teaching : Chairman of the Teaching Committee at the Dept . of Pharmacology and Pharmacotherapy , Faculty of Pharmaceutical Sciences , University of Copenhagen : from January 2008 August 2012 . Member of Didactic Committee at the Faculty of Pharmaceutical Sciences , University of Copenhagen : from January 2008 March 2012 . Member of the Committee for Research and Innovation at the Dept . of Drug Design and Pharmacology , University of Copenhagen : August 2012 May 2019 . Invited lecture Scandinavia : 1 The Scandinavian Physiological Society Annual Meeting , August 14 16 , 2009 , Uppsala , Sweden . The title of talk : calcitonin gene related peptide CGRP receptors and signaling pathway in vasculature . 2 Annual DARC Symposium Danish Arrhythmia Research Centre , 02 . November 2006 , Henrik Dam Auditorium , The Panum Institute , Organizer : prof . S ren Peter Olesen . The title of talk : vascular tone in health and disease 3 Biologue Matchmaking meeting within the field of cardiovascular diseases held at NeuroSearch A S and chaired by Prof. S ren Peter Olesen , 25 . November 2005 . The title of talk : Calcitonin gene related peptide CGRP : Cardiovascular effects and potential therapeutic applications . . Throughout my academic career , I have been focusing on the regulation of vascular tone in health and disease diabetes type I II , stroke , hypertension , congestive heart failure , migraine , and age related changes . Coronary arteries are densely innervated by sensory nerve endings containing calcitonin gene related peptide CGRP . CGRP is a potent naturally occurring 37 amino acid vasodilatory neuropeptide that is released from the perivascular sensory nerve endings in the wall of flow regulating intramural coronary arteries during hypoxia and by low pH levels in the myocardium , thus suggesting a vasodilatory role under ischemic conditions . So far , our studies demonstrate a larger CGRP receptor density in resistance arteries internal lumen diameter 200 m compared to larger conductance arteries internal lumen diameter 200 m , indicating that receptor distribution , calcium handling , ion channels , and second messengers may be finely adjusted within the circulatory system , probably reflecting the physiological demands on the vascular segments . CGRP receptor consists of three components , calcitonin receptor like receptor CLR , a specific chaperone called receptor activity modifying protein 1 RAMP1 , and receptor component protein RCP . A novel family of chaperone proteins , called RAMPs RAMP1 , RAMP2 , and RAMP3 were identified as proteins escorting CLR to the plasma membrane to generate either CGRP when associated with RAMP1 or adrenomedullin receptors when associated with RAMP2 or RAMP3 . CLR belongs to class B of the G protein coupled receptor GPCR family and is linked to Gs protein . Our studies will shed light on the complexity of CGRP receptor pharmacology as well as its complex signaling pathway , thereby helping us understand its physiology as well as its role under different circulatory complications such as stroke , ischemia , hypertension , and migraine . Techniques and specialties : Myography wire and pressurized , Electric field stimulation , Langendorff perfused heart preparation , fluorescence microscopy , stereology , measurement of intracellular calcium concentration , Investigations of G protein coupled receptor signaling pathways , and other classical molecular biology methods .. Technologies :",
"Head Of Department . Leading early research activities in oral macromolecule delivery . Driving research strategy and prioritization . Exploring new avenues of treatment in diabetes , CVD , haemophilia and other life threatening diseases . . Passionate people manager and scientist . Currently heading Oral Drug Product Research at Novo Nordisk . Competencies : Leadership and management Preclinical research strategy Project management Outsourcing and academic collaborations Scientific skillsets : Protein biophysics and interaction Oral and injectable formulation of biologics Drug discovery HTS Small molecules , peptides , proteins and oligonucleotides as drug modalities . Technologies :",carriers;nucleic acids;peptides;proteins;small molecules;characterization;interaction;screening
"Senior Director , Computational Biology NGS Bioinformatics . R D Analytics , HPC Algorithms Software Hardware , AI , Cloud Local Software Engineering , Data and Network Management , Web UI . . Currently in charge of R D Analytics , HPC Algorithms Software Hardware , AI , Cloud Local Software Engineering , Data and Network Management , Web UI . Developer of core algorithms for application specific base calling , alignment , assembly , error correction , and SNV CNV Fusion Expression calling . Coded and integrated those methods into customer facing software on the local server and cloud infrastructures . Delivered multiple internal R D software tools used to improve sequencing chemistry , enzymes , library construction , templating , and signal collection hardware . R D Leader for Liquid Biopsy cfDNA and cfRNA analysis applications . Working with multidisciplinary teams of Molecular Biologists , Chemists , Hardware and Software engineers , and Clinical Genomics Oncologists Pathologists collaborators . Designed the whole solution , performed analysis and created software tools to enable novel library preparation , instrument , and sequencing technologies in order to develop an efficient algorithm to deliver best in class solution for detecting SNV CNV Fusion variants under 0.1 limit of detection . Manager of R D algorithm development team responsible for developing applications in the area of Oncology , Liquid Biopsies , Immuno Oncology , Immune Repertoire , Infectious Diseases , and Pharmaco Genomics . Have strong algorithm design , programming , mathematical modeling , and analytical skills . Spent lots of time analyzing patient samples or population derived NGS data from internal and external collaborators , and data with purposely constructed experimental designs to answer challenging biological and technology questions . Have good insights for explaining technology artifacts vs real biology based on sequencing data . Well familiar with PCP product development cycle , and with Agile software development life cycles . Author of 11 US Patents in computational methods and NGS application techniques . Published numerous high profile papers and recently presented at multiple top conferences in Oncology , Pathology , and Computational Biology Methods .. Technologies :",
"Instructor in Medicine , Division of Sleep and Circadian Disorders . Ongoing next generation sequencing analysis of healthy and disordered sleep and related comorbidities in the NHLBI TOPMed Consortium . Large scale electronic health record EHR analyses of sleep apnea and its relationship to COVID 19 and other disorders . . Specializing in human sleep , circadian rhythms and related comorbidities research using genetic epidemiology , GWAS , whole genome sequencing , and bioinformatics . 77 . Multi ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation . Nat Genet 2022 accepted . 76 . Assessing the Contribution of Rare Genetic Variants to Phenotypes of Chronic Obstructive Pulmonary Disease Using Whole Genome Sequence Data . Human Mol Genet 2022 accepted . 75 . Polygenic Transcriptome Risk Scores for COPD and Lung Function Improve Cross ethnic Portability of Prediction in the NHLBI TOPMed Program . AJHG 2022 accepted . 74 . Rare coding variants in RCN3 are associated with blood pressure . BMC Genomics 2022 Feb 19;23 1 : 148 . 73 . Pathway specific Polygenic Risk Scores PRS identify OSA related pathways differentially moderating genetic susceptibility to CAD . Circ Genom Precis Med 2022 accepted . 72 . Upregulated heme biosynthesis increases obstructive sleep apnea severity : a pathway based mendelian randomization study . Scientific Reports Sci Rep. 2022;12 1 : 1472 . 71 . Sleep Apnea Phenotyping and Relationship to Disease in a Large Clinical Biobank . JAMIA Open 2022;5 1 : ooab117 . 70 . Genetic determinants of telomere length from 109,122 ancestrally diverse whole genome sequences in TOPMed . Cell Genomics 2022 2:100084 . 68 . Rare coding variants in 35 genes associate with circulating lipid levels a multi ancestry analysis of 170,000 exomes . AJHG 2022 ; 109 1 : 81 96 . 67 . Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank . BMC Medicine 2022;20 1 : 5 . 66 . The power of genetic diversity in genome wide association studies of lipids . Nature . 2021 Dec 9 online ahead of print . 62 . Whole Genome Association Analyses of Sleep disordered Breathing Phenotypes in the NHLBI TOPMed Program . Genome Medicine 2021 Aug 26;13 1 : 136 . 54 . Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program . Nature 2021 ; 590 7845 : 290 299 . 51 . Sleep Apnea and Covid 19 Mortality and Hospitalization . AJRCCM 2020 ; 202 10 : 1462 1464 . Preprints 87 . MedRxiv 2022.02.16.22271055 . 86 . BioRxiv 2022.01.07.475305 . 85 . MedRxiv 2021.12.15.21267852 . 84 . BioRxiv 2021.12.10.471810 . 83 . BioRxiv 2021.12.07.470215 . 82 . BioRxiv 2021.11.05.467531 . 81 . BioRxiv 2021.10.11.463514 . 80 . BioRxiv 749010 . 79 . MedRxiv 2020.12.31.20234310 . 78 . MedRxiv 2020.11.13.20221812 . Full bibliography available at : https : orcid.org 0000 0003 1424 0673 . Technologies :",
"Senior Associate Scientist . API Commercial Scale Up supporting project management from Process Validation Characterisation , data interpretation , Lab Investigations , Protocol Report Authoring for BLA filing . Co ordination of Scale up analytical testing with multiple third party depts . , Event Deviation support troubleshooting to meet business needs . Co ordination of New Oncology Product Stability Management , Bioassay Analytical Method transfers , Verifications and Co Validations , Equipment procurement and qualification for expanding NPI portfolio . Implement Transfer Guidelines to support introduction of new technologies for global Bioassay team . Co ordination of Clinical and Release Sample testing of In Process , FVP , FLP , FB , PFS and Stability Bioanalytical testing within product testing group . Implement and author Training modules to support Analyst Training , Technical coaching training of area personnel on specific cell based bioassays and Process Impurity tests qPCR , Elisa and HCP . Perform Data and Method Technical Investigations DOE , review and approval Including Deviations , CAPA s and Change Controls . Technical liaison with Bioassay Method Development Group , external vendors and 3rd level institutions relevant government bodies As SME primary point of contact . Yellow Belt accreditation ; use of problem solving tools to determine root cause of events A3 , fishbone , 5 Why s . Participate in Process Improvement initiatives through Lean labs and encourage use of Kaizen tools , 6S within CRS team . Participate in risk assessments , inspections , audits , etc . and implement and follow up Change Controls and CAPA s assigned . Audit External Contract Facilities to support Outsourcing Initiatives . Cork CRS Bioassay representative for qPCR , HCP , Cell based Bioassay Methods and new Non Platform Method introduction to Cork CRS . . . Profile : Senior Associate Scientist who as a member of the PDMS dept . , Janssen Sciences Ireland JSI is committed to Process Validation Characterisation for commercial Scale Up of Large Molecule monoclonal antibody production . Previously as a member of the Clinical Release Stability dept in JSI , I was committed to Bioassay transfers co validations , cell culture , troubleshooting within the USP guidelines in a GLP , GMP , ISO regulated quality pharmaceutical environment . I have over 10 years experience in Microbiology , Medical Device Diagnostics , Clinical Research and Biopharmaceutical Manufacturing Facilities . Throughout this time , I have gained great experience across a variety of Project Management , Technical and Leadership roles within R D and Quality . I have a proven ability to work as a dedicated team member within my department and with various business units , but am also very capable of working independently . I have built up a solid reputation at a local level for being reliable and capable of making important interpersonal and analytical decisions . My scientific background allows me to be technically minded , while my quality based experience allows me to deal with issues in a compliant and effective manner . I have strong verbal and written communication skills and excellent interpersonal skills . . Technologies :",antibodies;quality
Associate Professor . . Medical Biotechnology research with focus on organoids and advanced imaging techniques . Always looking for interesting new projects and collaborations . Specialties : Membrane protein expression and crystallisation . Biochemistry . Crystallographic data collection and analysis . cryoET and in vivo structural biology . Organoids . X ray imaging techniques .. Technologies : Xray,membrane proteins;expression;structure
"Director Scientific Products , Scientific Product Line Manager . Responsible for team of product managers and portfolio of 100 products and tools for 600 Data and Computational Scientists at NIBR ; liaison for large scale compute and storage infrastructure needs spanning on prem and cloud options . . IT leader experienced in building cross functional teams delivering impactful informatics solutions .. Technologies :",
"Postdoctoral Researcher . 1 Proteomic analysis of transmembrane proteins GPCRs , Calcium ATPases 2 Large scale purification of transmembrane protein complexes for Cryo EM . . Technologies : CryoEM",membrane proteins;structure
"Senior Scientist . . I am motivated in understanding nature and people . I find great fulfillment when helping others to perform at their best and advocate for respect to diversity , trust , and collaboration . I have a deep scientific interest in understanding the fundamental principles that govern protein function and regulation with a focus on the cellular networks that are connected to cell death . I have a Ph.D. in Biology with experience in biochemistry , biophysics , molecular and cell biology , and quantitative light microscopy . I currently apply these methods to disclose essential steps for the regulation and execution of cell death as new potential targets in the clinics . I have strong experience in leading and working in interdisciplinary and multicultural teams , in addition to project management and training and supervision of students . I am enthusiastic about learning while solving concrete problems and open to new challenges . I like to set ambitious goals and reach them while working in teams .. Technologies :",proteins;small molecules;interaction
"Senior Scientist In Vivo Pharmacology . . Currently I 'm working as a Senior Scientist In Vivo Pharmacology at eTheRNA immunotherapies , a biotech company focused on developing first in class mRNA immunotherapies for the treatment of cancer and infectious diseases . Within the translational team I 'm responsible in setting up the preclinical strategy of several projects and outlining and reporting of PD , PK , immunogenicity and GLP safety toxicity studies . Thereby also contributing to preparation of regulatory documents . In addition , for one of the oncology projects I 'm assigned as project leader . My career in the biotech industry started after obtaining a double PhD in Pharmacy at the Vrije Universiteit Brussel and in Veterinary Sciences at the University of S o Paulo . I first started as an Associate Scientist in the Exploratory Pharmacology team at Ablynx , who develops single domain antibody fragments Nanobodies in several disease areas . Afterwards , I got the opportunity to work as a Senior R D Manager at Promethera Biosciences , developing cell based therapies for treatment of liver diseases . Recently , in November 2021 , I obtained a certification as Diplomate of the American Board of Toxicology DABT . . Technologies :",nucleic acids
"Associate Director , Immunology Program . . Associate Director of the Immunology program directed by Dr. Ramnik Xavier at the Broad Institute Former scientific Editor at Cell , with a focus on immunology , cancer , biophysics and computational biology PhD in immunology in the field of cancer immunology , and NK and T cell response , with 4 years post doctotral experience studying inflammation and neutrophil functions Proficient with flow cytometry , microscopy and intravital imaging , common biochemistry techniques Experience with bioinformatics RNAseq , image analysis and programming R , Python , Android for both research and business analytics Complete publication list : https : scholar.google.com citations user lFM9OHsAAAAJ hl en . Technologies :",
"Professor of Computer Science Bioinformatics . . I am broadly interested in bioinformatics and data science education and research , with much of my research involving undergraduate students . I regularly teach classes involving coding in Java , Python , and R ; computational and analytical methods in bioinformatics and data science ; and how to conduct and communicate research . Recent research projects have involved the development of a web application for analyzing genomic data ; a tool for quickly summarizing and searching cancer genomic literature ; and a COVID 19 dashboard for CT and its counties . Other recent work has involved the development and analysis of epidemiological simulations of COVID 19 , and the sentiment and network analyses of Twitter data . For more information about my teaching and research , please visit https : gdancik.github.io bioinformatics . Former students and others , please let me know if there are any job openings or internship opportunities at your company . . Technologies :",
"Scientist . . Our rapidly changing world has created new and emerging challenges to human health and environment . These problems do n't have simple solutions and require us to re think how we interact with complex , living systems . Using science , math , and computers we can build and test living systems in our imagination . These thought experiments can help us understand how cells work like economies , how tumors will respond to treatment , or how ecosystems are affected by environmental perturbations . As a scientist , I want to create insight into how these systems work . As an engineer , I want to design new strategies for therapeutic treatments , bioprocess optimization , and maximizing ecosystem productivity . I 've spent years acquiring a highly interdisciplinary education . I 've worked in clinical , translational , and basic biomedical research . I 've cross trained both as a bench scientist and as a computer modeler . In the lab , I 've done everything from animal surgeries to molecular biology . While working on my PhD , I helped biotech companies create quantitiative models of their therapeutic and manufacturing platforms . There are n't many scientists who demonstrate this kind of versatility . I am a committed science educator . Science is a gateway for teaching empathy , understanding , and a moral foundation based on reason . To solve challenges of the 21st century , we need deep , critical , scientific thinkers in every corner of society . . Technologies :",
"Project Leader . . In constant search for better pursuits in career and in life I am a detail oriented scientist with over 7 years of experience in Drug target integral membrane proteins inner and outer , at several leading academic institutions in India , Germany and Switzerland . I am skilled in various biophysical and biochemical techniques required for structural biology , biochemistry and biophysics , writing and evaluating scientific reports publications . Capable of working as a team member as well as independently . Fluent in English , Hindi , Punjabi and can converse in German B2 C1 .. Technologies :",membrane proteins;characterization;structure
"Associate Principal Scientist . Develop iPS , stem cells primary cells based phenotypic assays and run phenotypic screens Discipline lead for phenotypic assay technology and Flow Cytometry to define bottlenecks of phenotypic assays , identify implement cutting edge technologies and explore new technologies for setting up physiologically relevant in vitro models Study 3D culture cardiac models Design and propose target based and phenotype based screening strategies cascades with biological relevant assays and screening risk assessment Long term experience and deep knowledge on ion channel and receptors pharmacology and screening Worked as Campaign Leader for several ion channel target projects Several years experiences of running HTS screening of diverse targets including GPCRs , ion channels , Kinases , and peptidases Deep datahandling experiences knowledge of both large and small scale screening results . A researcher with significant experiences within the disciplines of assay design , cellular assay development , high throughput flow cytometry , screening of phenotype based and target based drug discovery projects .. Technologies :",membrane proteins;proteins;small molecules;interaction;screening
"Assistant Associate Professor . . Joanna Rorbach is a Group Leader at Karolinska Institute , Stockholm , with extended experience in molecular biology , genetics and biotechnology . Joanna work is focused on discovering the links between mitochondrial dysfunction and human disease . Her studies employ primary human samples , genetic , proteomic and cryo EM methods to reveal novel mechanisms and protein factors involved in mitochondrial function . Over the past years , she has co authored multiple publications , attracted highly competitive funding and received prestigious fellowships . Joanna holds a Ph.D. from University of Newcastle and conducted post doctoral training at the MRC MBU in Cambridge .. Technologies : CryoEM",proteins;structure
"Director , NGS Bioinformatics . . . Technologies :",
Vector Synthesis Research Associate II . . . Technologies :,
"Scientist I Biochemistry and Protein Engineering . . I am a highly motivated scientist with a PhD in Biochemistry and Molecular Biology . I currently have 1 first author publication in the journal Nature , and 8 co author publications . I have ten years of experience in the field of protein biochemistry , and my expertise is in enzymology and structural biology . I am interested in leveraging my diverse skill set and deep understanding of the scientific method for solving difficult problems .. Technologies :",enzymes;proteins;structure
"Senior Scientist in Protein Production and Biochemistry Consultant from Qrios . . Hi I am an enthusiastic and curious scientist with eleven years of experience in the field of protein science , molecular biology , biochemistry , and biotechnology . I obtained my PhD degree from Complutense University in Madrid working in the field of Industrial Biotechnology where I focused on the characterization of enzymes for their application in the industry for bioremediation and paper pulp bleaching . Later on , I have worked at Chalmers University on the protein engineering of enzymes for the sustainable production of bio based adipic acid . During my years working as a researcher , I have acquired a strong background on structure function studies , recombinant expression , purification and characterization of proteins , biochemical assay development , enzymology , molecular biology , genetic engineering techniques , microbiology and analytical chemistry . I have experience in project management , including project design , planning , execution and troubleshooting . I like to look for creative solutions to challenging research problems . I am used to analyse complex data and communicate scientific results in an efficiency way . Also , I am a team player and like to collaborate with others to accomplish a common goal . My colleagues use to describe me as an easy going and reliable person , that helps to create a productive work environment . I would like to work in a position where I can apply my knowledge and expertise to obtain high quality results useful for the society . Learning about new techniques and topics related with Life Science is also a very important goal for me . Thank you for visiting my profile Do not hesitate to contact me at versa1985 gmail.com . Technologies :",enzymes;proteins;characterization;expression
"Research Assistant . Cryo EM . Marina is an aspiring plant biologist and will begin her PhD in Plant Biology at UC Riverside starting Fall 2022 . She earned her BSc in Cellular and Molecular Biology from the University of La Verne and graduated from the Honors Program . She conducted her senior thesis research in the lab of Stacey Darling Novak where she studied first leaf formation in S. plicata identifying novel auxin mediated genes . Marina spent four years in industry at Lumos Diagnostics , Cibus and the San Diego County Public Health Lab before joining the Grotjahn and Williamson labs . The labs began their collaboration in 2019 and Marina is currently using cryo electron microscopy to visualize ribosomal intermediates in E.coli . Outside of research , Marina loves to spend time with her cats , make pies , camp , compost , and grow odd vegetables .. Technologies : CryoEM",proteins;structure
"Associate Director Group Leader for Translational Statistics . . Saran is a University of Pennsylvania and Harvard trained Ph.D. scientist with interdisciplinary training in biostatistics , bioinformatics and computer science and combined 10 years of education , research and working experience in academic , healthcare and pharmaceuticals sectors . His experience covers clinical trials design analysis , high dimensional statistical analysis , data mining and predictive modeling in pharmaceutical , healthcare and life science fields . . Technologies :",
"Bioinformatics Scientist . Working as a bioinformatics scientist under the core bioinformatics team at Guardant health , maintaining and developing bioinformatics pipelines and managing clinical relations . . Senior year Bioinformatics PhD candidate at Indiana University , working in a human microbiome lab under the direct supervision of Professor Yuzhen Ye : https : homes.luddy.indiana.edu yye lab index.php Passionate in general health and well being with a particular interest in understanding and improving human health , via integrating information from various levels . General interests include human microbiome especially the gut , understanding , assessing and predicting pathogenic and benign variants at the genome level via data mining and machine learning . General interest in applied machine learning and computational comparative genomics .. Technologies :",
"Research Scientist High Throughput Biology and Screening . . Internationally experienced Scientist with a demonstrated history of working in the fields of virology , high throughput screening , PROTACs and drug discovery . https : orcid.org 0000 0002 9660 8058 . Technologies :",molecular glues;small molecules;developing;screening
President of the Organization for Computational Neurosciences . . . Technologies :,
"Scientist , Structural Biology . Support gene to structure pipeline across multiple projects and project teams Communicate scientific results and prepare reports for internal and external purposes including regulatory submissions Participate and lead project based and technical team meetings to identify and solve problems , guide work towards project goals , communicate on going work and progress , and plan forward thinking strategies Proactively investigate new or different technologies , methods , and service providers to ensure our work is being done in a scientifically sound , efficient , and reasonable way . I am a highly motivated and team oriented biochemical scientist with skills in protein purification and X ray crystallography . During my graduate study and post doctoral study , I have solved over 20 macromolecular structures through X ray crystallography using proteins or ribosomes I ve purified . As a post doctoral fellow , I gained experience in the areas of teaching , training , and management . I have mentored both undergraduate and graduate students , laboratory technicians and other Ph . D postdoctoral fellows . I was also responsible for purchasing and configuring computational resources along with establishing a user reservation system for the university s new cryo EM core facility . I have utilized my technical expertise to perform tasks safely and stay on schedule .. Technologies : Xray;CryoEM",proteins;structure
"Principal Scientist , Translational Research . I am a Principal Scientist in the translational research division at Tempus Labs . . I am a Principal Scientist in the Translational Research division at Tempus Labs . My role is interdisciplinary , working at the intersection of data science , software engineering , cancer biology , and genomics . I am passionate about open source software , data science , and the R programming language . I build tools , software , and infrastructure to enable data science for genomics . I have been a core team member of two successful open source bioinformatics projects . I was at the Bioconductor Project https : bioconductor.org at Dana Farber Harvard Medical School and Roswell Park . My focus was on making R Bioconductor based genomic data science scalable on the cloud . I was also a core team member for the Galaxy Project https : galaxyproject.org at Johns Hopkins . Bioconductor and the Galaxy project are computational milestones in Bioinformatics , as listed in this Nature Review paper https : www.nature.com articles nature24286 bx2 . I 'm always looking to hear from interesting people . Feel free to contact me if you 'd like to connect .. Technologies :",
"PhD Fellow . Determining the structure of a bacteriophages using high resolution cryo EM and advanced molecular biology techniques . Project funded by the Leo Foundation Open Competition Grant 2019 . I am currently pursuing research in the field of structural biology analyzing bacteriophages using cryo EM and using other molecular biology techniques . Professional Competencies Bacteriophages propagation , purification and analysis CRISPR Cas based genome editing Cryo EM sample preparation , image processing and data analysis Proficient with RELION , CryoSPARC , cisTEM , Coot , Chimera and other EM data analysis tools Scientific communication and networking Bioinformatics basic I enjoy reading about different topics , ranging from science to pop culture . Productive networking over a cup of chai coffee is always welcome . Highly interested in innovation and entrepreneurship in life sciences .. Technologies : CryoEM",proteins;structure
"Computational Chemist . . I work in the fields of biophysics and computational biology . My research focuses on studying lipid interactions with membrane proteins and developing algorithms for characterising binding activities . In addition , I also have a strong background in python programming and mathematical modelling . I have developed a python package for calculating binding kinetics and used Markov State Modelling to study GPCR oligomerisation . Through my PhD training , I have also participated in projects of computer aided drug design and fragment based drug design . . Technologies :",
"Chemical Biology Therapeutics Associate Director , Data Science . . I am an experimental biologist turned bioinformatician turned data scientist , having first shifted from the bench during a decade of infectious diseases research that spanned my graduate career and my first seven years in industry . In 2018 , I changed course to leverage data science and chemical biology approaches across a broad portfolio of drug discovery projects within the Novartis Institutes for BioMedical Research . While my research on infectious diseases has waned greatly in recent years , I continue to help in the search for parasite anti infectives in collaboration with the co located Novartis Institute for Tropical Diseases . I am most interested in tool development , machine learning , and their application to problems in drug discovery research , particularly for induced proximity modalities . As the lead for the local CBT Data Science team , a small group of data scientists , I most enjoy collaborating with and enabling experimental colleagues , from helping with experimental design to visualizing and interpreting results . I 'm a father of four , an avid live music and sports fan , and an amateur musician . I serve as Director of Technology on the board of the Mockingbird Foundation , a nonprofit that raises and disburses funds to children 's music programs across the United States .. Technologies :",
Team Leader Particle Science . . . Technologies :,
Research Manager . . . Technologies :,
"Engineering Manager . Engineering manager for the two teams working on Auth , Profile , Trust and Communication . . I 've always found my main motivation in understanding problems and finding good solutions to them . In my previous career I tried to find new solutions for studies of membrane proteins . I then spent a couple of year writing code to improve the experience in the Blocket android app . Nowadays I mostly focus on understanding the technical aspects of our business needs in my domains , figuring out architectural problems and on helping for my team although I still do the occasional PR in Python , React , Android , ... . The kind of problems I 've worked on have changed over the years , but the driving motivation to understand the problem and solve it has stayed the same . Technologies :",
". . I got my Bachelor in chemistry from Baghdad University . In 2011 I started to study analytical chemistry at Lund University . To get experience in biochemical and related methods . I started in 2012 studying the program in Molecular Protein Science 2012 2014 at the department of Biochemistry and Structural Biology , Lund University My Master s degree work , which is planned to be finished in May 2014 , is in molecular biophysics . My work in the Master s program was divided into three parts : 1 . Protein expressed and purification . 2 . In vitro the enzyme was tested with different inhibitors and the IC 50 was predicted for every inhibitor . 3 . Protein crystallization must possess some specific properties for the formation and growths of the crystal therefore we used different methods such as Differential Scanning Fluorimetry DSF and Dynamic Light Scattering DLS to optimize those conditions . I used different conditions to optimize the protein crystals with various inhibitors I am very interested in my project structural biology , because I passed three advanced courses . The courses are : Structural Bioinformatics , Medicinal chemistry inhibitor design , inhibitor synthase and inhibitor scanning in vitro and inhibitor analysis in pharmacokinetics and Biochemistry advance energetic metabolism , protein structure and function and purification of a membrane protein .. Technologies : SLS DLS;DSF",membrane proteins;interaction;structure
"Staff Scientist Microscopist . . Specialties : Light Microscopy , Multi photon live cell confocal imaging Electron Microscopy TEM SEM Cryo Electron Microscopy . Technologies : CryoEM",structure
Bioinformatics Scientist . . . Technologies :,
PHD Graduate Student . Buchmann Institute for Molecular Life Sciences BMLS ; Prof. Frangakis group Cryo Electron Microscopy Tomography Antibiotic resistance of gram negative bacteria Structural Biology of membrane proteins in situ and in vitro . PhD student in Biochemistry and Cryo Electron Microscopy . . Technologies : CryoEM,membrane proteins;structure
Cryo EM Facility Manager . . . Technologies : CryoEM,
"PHD Student . PHD research on protein aggregation and neurodegeneration as part of the Graduate School of Quantitative Biosciences Munich QBM program . . My research career started with biotechnology , treaded through nanoscience , and concluded with a Ph.D. in Biochemistry that is currently awaiting defense . During my PhD I have learned important technical knowledge of yeast biochemistry and cryo electron microscopy , where my previous knowledge of genetic manipulation and microbiology proved invaluable . Not less important were teamwork and leadership skills which were essential when training newcomers to our department . At this point in my career , I have decided to make the jump from an academic research career to one either in industry or in public institutions . I aim to use my technical knowledge and human skills to pursue a career in management and hold positions of increasing responsibility .. Technologies : CryoEM",idps;structure
"Electron Microscopy Specialist . Microscopy : FEI Morgagni , Tecnai G2 20 , Glacios Cryo TEM , Hitachi TM 1000 , Tescan S8000 G Cryo FIB SEM Preparation techniques : conventional chemical fixation for transmission electron microscopy , sample preparation for scanning electron microscopy , critical point drying , high pressure freezing , freeze substitution , negative staining , plunge freezing immersion freezing for cryo EM , ultramicrotomy , sputtering of different metals , carbon grid production . Small things can make a big difference . Technologies : CryoEM",structure
"Director of iNANO . . Research : My research interests concern nuclear magnetic resonance NMR and magnetic resonance imaging MRI with specific focus on membrane proteins and fibrillating proteins and related diseases . Organization education : Director of Engineering Studies at Aarhus School of Engineering ASE . I am responsible for a newly started education in chemical engineering . Specialties : NMR , MRI . Technologies : NMR",idps;membrane proteins;structure
"Stability Scientist . . My competences include recombinant production , purification and characterization of fungal and plant enzymes and some of the most challenging and biomedically most interesting proteins ; ion channels of human and parasite origin . During my Ph.D. at the University of Copenhagen I was the first to purify the full length human hERG K channel , an ion channel of utmost importance to heart physiology and for drug screening , and the only two K channels encoded by the malaria parasite , plasmodium falciparum , it their active form . I developed expression , purification and fermentation protocols for production in S. cerevisiae and managed to purify material enough for electrophysiological characterization and structure determination . Based on my experience with these very challenging proteins I have obtained in depth experience with pilot plant scale yeast fermentation , expression optimization , detergents , protein purification using the kta explorer , ion channel characterization and DNA technology . Key words : Recombinant protein technology , Membrane protein expression , characterization and purification , Parasitology , Molecular techniques , Malaria , hERG , Ion channels , Electro physiology Biochemistry , Cell biology , Medical research , Vaccine technology , Cell culturing , Fermentation . Cloning , Sequencing , siRNA assays , FELASA accreditation , PCR , FACS , ELISA . . Technologies :",membrane proteins;characterization;expression;structure
"Head of Operations Senior Scientist CryoEM Core Facility , Center for Structural Systems Biology . . Biochemist with a strong structural biology background . Completed multiple projects in the areas of cryoEM , XFEL science and NMR . Focused on structure function relationship studies of helical assemblies , membrane proteins and protein complexes . Currently heading the cryoEM facility at CSSB with 2 Titan Krios , 1 Arctica , 1 Aquilos FIB SEM and an Talos L120 . With a team of EM specialists , supporting PhDs and postdoctoral researchers in visualizing infectious processes at high spatial resolution , and ultimately inside the cell exploiting single particle analysis and electron cryo tomography . Further engaged in research and development projects on campus that push the limits of CryoEM , the portfolio of facility , and growth of every team member . Projects include : integrative cryoEM XFEL SAXS approaches , tr cryo EM sample preparation , and cryo CLEM .. Technologies : CryoEM;NMR",membrane proteins;proteins;structure
"Associate Director , Data Science . Exploratory biomarkers in clinical development . Extensive experience in leading Translational Bioinformatics and Clinical Biomarkers efforts in Clinical Development . Specialties : Clinical Cancer Genomics Bioinformatics Clinical Biomarkers Assay Vendor selection , DTS , Clinical trial documents , sample logistics , CDx Machine learning : Scikit learn , Keras , Tensorflow Bioinformatics Data Analysis : Next generation sequencing Programming Languages : python , R , SQL , matlab , unix shell Biological Experiments : FACS , NGS library preparation , Cell Biology Experiments , Molecular Biology Experiments , Mouse Genetics . Technologies :",
"Principal Computational Biologist . https : www.bluestargenomics.com . Seasoned computational biologist with strong knowledge and experience in data analysis and experiment design for high dimension data , including : NGS , microarrays and proteomics technologies . Excellent working experience in the area of liquid biopsy , target identification validation , drug MOA , patient stratification and biomarker identification . Excellent skills in R , Perl and Java . . Technologies :",
"Computational Biology Researcher . Lead an independent project investigating how Xenopus laevis tadpoles identify physical deformity in others of their species , through a computational analysis pipeline . This research was funded by one of two 2020 2021 Arnold O. Beckman Scholarship awards at Tufts University Mar. 2020 Oct. 2021 Use state of the art computer vision software Ethovision XT15 to track movement and behavior of 30 tadpoles Design a robust Python program to identify collisions among tadpoles from noisy coordinate location data , calculate and report metrics of aggression in tadpole collisions , and visualize results Create Python scripts to split and clean 1,600,000 line data files , automate ImageJ image analysis and data collection , and organize files and directories for own research and to assist doctoral and post doctoral colleagues Present research at lab meetings , in written manuscripts and course papers , and in a poster at the 2021 Arnold and Mabel Beckman Foundation Symposium . . Technologies :",
"Research Director . . Application of machine learning and statistical physics methods in biophysics , structural and systems biology .. Technologies :",
"postdoc . . I am a cell biologist with a PhD in Biophysics , looking for new challenges outside the ivory tower of basic academic research . For over 10 years I have studied the microtubule cell skeleton along with it 's associated motor proteins . I am a passionate electron microscopist and have vast experience in Cryo EM as well as the subsequent image processing . When I sit in front of the microscope it feels like home . My work culminated in successfully completing projects determining the structures of Dynactin and Kinesin 8 . In my last project I focused on light microscopy techniques with optical trapping and TIRF microscopy . So that I will be able to link functional data with structural information .. Technologies : CryoEM",proteins;structure
"Head , Exploratory Statistics , AbbVie Bay Area . . Translational data scientist with extensive experience in bioinformatic statistical analysis of genetics genomics proteomics data and biomarker research in biotech pharmaceutical companies . Experienced leader in building and managing productive bioinformatics biostatistics teams . Currently focusing on biomarker data analysis for discovery and clinical trials in Oncology . Specialties : biomarker data analysis , statistical genetics , omics data analysis , survival analysis , machine learning , statistical consulting , experimental design , algorithm development , software development , oncology , autoimmune disease .. Technologies :",
Assistant Professor . Institut de Biologie Structurale Guy Schoehn group Structural analysis of hantavirus replication by cryo electron microscopy . . Technologies : CryoEM,proteins;structure
"Principal Scientist , Bioinformatics . . . Technologies :",
"QC Scientist in General Chemistry . . Over the past 13 years my professional experiences have given me technical , interpersonal and organizational skills . I have experience with managing projects , planning and conducting development and validation studies , technical transfer of analytical procedures , CMO collaboration as well as process validation . I have several years of experience with GMP , ISO13485 and compliance . I have worked with immunology from antibody production to characterization , as well as been responsible for several types of immunochemical and biochemical methods . I have a high quality mindset and an analytical approach to my tasks . I am used to plan , prioritize and execute my tasks to meet the agreed schedule and quality . I have a positive mindset , easy to get on with , flexible and reliable . I enjoy working with people and get inspired by being a part of a team , find solutions as well as learning new things . . Technologies :",
"Senior Computational Scientist . . Professional computational scientist software engineer with 20 years of experience developing software for scientific , medical , and imaging applications from the user interface level all the way down to hardware interfaces . I completed a master s degree in biological sciences biotechnology in 2012 and have since gained valuable experience in bioinformatics , computational biology , cloud computing , automation , robotics , and database technologies .. Technologies :",
PHD Student . Membrane protein biochemistry Cryo EM single particle analysis of membrane proteins Trainee supervision . . Technologies : CryoEM,membrane proteins;structure
"Staff Scientist , Research Informatics . Collaborate with researchers and provide support of genomic data analysis for basic research and translational studies , including NGS data analysis , data mining and interpretation , publishing manuscripts and writing grants . Research and implement translational research informatics platform , enhanced tranSMART by integrating with patient data in i2b2 and Machine Learning . Investigated on the computational deconvolution method using DNA methylation data for tumor profiling analysis . managed the research IT infrastructure which includes scientific software , LIMS Lab Information Management System , high performance computing infrastructure , and cluster storage resources . . Technologies :",
"Postdoctoral Researcher . Cryo tomography and subtomogram averaging . I am a Structural Biologist with expertise in molecular biology , protein biochemistry , single particle cryo EM and related computation especially image processing , model building and refinement in electron density maps . Dabbling in FIB milling , cryo tomography , subtomogram averaging .... Technologies : CryoEM",proteins;structure
"Senior research associate . Negative staining Cryo EM Production , purification et cristallisation de prot ines recombinantes Responsable plateforme de production en organisme procaryote . . Technologies : CryoEM",proteins;structure
"Postdoctoral Research Scholar . . I am currently working as a postdoctoral fellow in James Hurley 's group at Berkeley . I am focused on dynamic protein complexes and how they confer function . Currently in the context of autophagy initiation using Cryo EM , Cryo ET , cell biology and Cryo FIB SEM approaches .. Technologies : CryoEM",structure
"Senior Principal Bioinformatics Scientist . Lead technical teams responsible for real time software on DNA sequencing instruments , instrument control software for breadboards and prototypes , and compute hardware Received 2022 annual innovation award for signal processing improvements to primary analysis software Present technical roadmap proposals and updates for on instrument software to executive leadership team Contributed to the development of a strong software patent portfolio in the areas of signal processing , patterned flowcells , and AI ML for sequencing Program lead for the integration of Emedgene team and technology . I am a senior leader with over 15 years of experience building and mentoring technical teams , bringing early stage technology development to market , and leading strategic programs . My technical work on image and signal processing and compute hardware at Illumina has enabled the sub 1,000 genome and been recognized with a company wide , annual innovation award . I also led the post acquisition program that integrated Edico and ultimately led to DRAGEN becoming the most efficient and accurate secondary analysis of sequencing data . Specialties : Instrument control , system simulation , primary analysis , DNA sequencing , image processing , computational chemistry , molecular modeling , high performance computing , algorithm development , technical lead , program lead Keywords : John Vieceli , San Diego , Illumina , Biotech , Scientific , Engineering , Next Generation Sequencing , NGS , Genetics , Genomics , Software , Bioinformatics , Image Processing , Scientific Computing , Algorithm Development , High Performance Computing , Computer Science , GPU , FPGA , SIMD , AVX , AVX2 . Technologies :",
"Data Scientist Statistician . Data Scientist and Statistical Consultant in the Bay Area . As a contract consultant , I use my background in applied statistics , Bayesian modeling , and Machine Learning to model corporately owned data sets . . . Technologies :",
"Professor . . I started my research career at Uppsala University where I in 2006 received a PhD degree for the bioinformatic discovery of 24 human receptors and the overall receptor repertoires in dog , mouse , rat and chicken . In 2006 7 , I was at the European Molecular Biology Laboratory EMBL Bioinformatics Institute where I developed a global protein informatics standard and data exchange format for protein affinity reagents . In 2007 2008 , I made another postdoc at GlaxoSmithKline where I conducted computational drug design and developed chemogenomic methods for ligand drug discovery . Since late 2008 , I have been at the University of Copenhagen where I have expanded my research to scientific database development , data science and experimental structural biology . My research focuses on G protein coupled receptors GPCRs the most abundant targets of physiological hormones and neurotransmitters as well as therapeutic drugs . My group develops computational and data driven methods for interdisciplinary receptor research and drug discovery , spanning : Biased signalling towards safer drugs and specific signalling probes Computational drug design Data science approaches to uncover receptor function Experimental structural biology The online research infrastructure GPCRdb . Technologies :",membrane proteins;structure
"Scientist . Building on the accomplishments of my 1st year at OXGENE , I am conducting more independent and in depth research in the field of promoter and enhancer discovery as well as experimenting with other molecular aspects impacting the regulation of transgene expression and its specificity in the context of gene therapy . . R D Scientist keen on conducting practical , independent , in silico to bench biological research that combines high volume data analysis with follow up wet lab validation . Particularly interested in computational biology and the field of multi omics . Concurrently with my main job responsibilities , I am developing and optimising bioinformatic pipelines for epigenetic and single cell assays as well as experimenting with machine learning , Nanopore and PacBio sequencing data .. Technologies :",
"Senior Research Scientist . Assay development to support different projects within our different disease areas . Three years of experience of CETSA , from building of assays to delivery of data . Two years experience of assay build and data generation for a PROTACs project . . . Technologies :",molecular glues;developing
Principal Researcher . Technology development bispecific antibody screening and microfluidics . Concept generation and project management . born as Achim Boltz . Technologies :,antibodies;screening
Patent Scientist . . . Technologies :,
Biomedical Engineering Society Advisor . . Digital and audio signal processing Improve noise robustness of auditory system model for word recognition in presence of challenging background noise Algorithm optimization Signal processing and statistical analysis Speech and natural language processing Experienced in clinical studies and algorithm development Strong knowledge of Biomedical sensors and systems for measuring physiological signals . Technologies :,
"Scientist . Lead of the A eta Project from high throughput screening to Lead candidate molecule selection . Design of high throughput experiments , data collection and analysis of C. elegans phenotypes for drug discovery approaches in both Alzheimer s and Parkinson s diseases . Trained new staff with less experience and maintained effictive communication . Developed new Metabolic and Biochemical assays specific for different custom made C. elegans strains expressing target proteins : A eta , Syn , IAPP , TDP 43 and Tau in muscle and neurons . I am a hardworking , enthusiastic and goal driven researcher with five years of experience in Industry and Academia currently working as a Scientist and Visiting scientist at Wren therapeutics and The University of Cambridge , UK . Previously , I was a Research Student at the University of Nottingham , Queen s Medical Centre and also worked as a Research and Teaching Assistant at the North South University , Bangladesh . I am passionate about research in the field of Biochemistry and I am seeking to gain professional experience and develop enhanced skills . Effective team player as I have been part of the STEMNET group ; who steps out , adapts to different roles to achieve targets . The research projects I have been involved so far are focused on : a Cell membrane biology , mostly focused on membrane proteins ATP binding cassette G2 ABCG2 structure and functional analysis . b Expression of ABCG2 in Insect cells sf9 through the infection by baculovirus and generation transfected BiiC stocks . c Bacterial Cell culture , antibiotic resistance and biochemical analysis . d Proteomics , Protein modelling , Structural Biology and Molecular evolution through Bioinformatics . e C. Elegans study for drug discovery and development to cure Alzheimer 's and Parkinson 's disease .. Technologies :",idps;proteins;expression;interaction;screening
"R D scientist immuno oncology reseacher Nanomedicine researcher . I am conducting research on the efficiency of drug loaded nanoparticles in cancer therapy . I am also determining nanoparticles induced immune response and examining the presence of immune cells in tumors . My project focuses explicitly on a polymer based nanoparticle delivery system in tumor bearing mice . We use breast cancer , cervical cancer , and colorectal cancer xenograft patient derived PDX as well as cell lines models to develop passive or active targeted therapy . I am investigating the accumulation and pharmacokinetics of nanoparticles in animals . I also examine the toxicity and anti cancer efficacy of drug loaded nanoparticles in pre clinical models . . PhD in cancer nanomedicine and oncoimmunology I believe in leveraging scientific expertise , analytical skills , communication , modern technology , and professional network to propel success . I have experience on working with different stages of drug development . I have been a part of many successful collaborations with our national and international collaborators . I drove some interesting projects during this time and built good relations with our partners . 13 years of scientific experience within oncology , nanomedicine , Immunology , Neurodegenerative diseases , Gestation biology , Hematology , Respiratory physiology and Pathology . Developed extensive network of HCP KOLs in different medical fields . Knowledge and understanding of ICH GCP , clinical trials , drug discovery , drug safety and pharmaceutics . Proven ability to make valuable contribution to the team strategy through key insights and experience gained from the field . Additional education in healthcare innovation and entrepreneurship from BI Norwegian Management School and University of Oslo . Acquired knowledge in important entrepreneurial aspects , including market research , regulatory affairs , stakeholders customer needs , financial aspects , business plans , smart risks , and revenue generation . Ability to contemplate commercialization of research idea discovery . Trained medical students : Respiratory biology , Hematology , Immunology . Extensive experience in writing scientific articles and grant applications . Key skills : Scientific expertise , business acumen , emotional intelligence , active listener Problem solving and conflict resolution through teamwork , collaboration , and relationship building Networking and relationship builder , communication and presentation skills . Influence , persuasion , confidence , optimism , patience , time management Microsoft Office , PRISM , Adobe Illustrator , Photoshop , InDesign , Image processing softwares . Documentation , record keeping SOPs , Data management Flexible , agile , multicultural , teaching and training Certificates in GCP , Project Management Foundation , Health Innovation and Entrepreneurship , Project Management : Healthcare Projects , CAREiN .. Technologies :",
"Application Scientist . Expertise in chromatography and multi angle light scattering , high throughput dynamic light scattering , field flow fractionation , differential refractometry and differential viscometry . Method development for chromatography FFF , SEC , IEC Expertise in analysis of viral vectors , proteins , polymers and particles by light scattering . Presentation of analytical methods and systems Hardware installation Customer support . Application Scientist in the field of chromatography and multi angle static light scattering , high throughput dynamic light scattering , field flow fractionation , differential refractometry and differential viscometry . Expertise in analysis of viral vectors , proteins , polymers and particles by light scattering . Furthermore , knowledge in structure based protein design , expression and purification of proteins , optogenetics , analytic characterization , and interaction studies . Moreover , I was involved in project management , supervision of students and employees , cooperation with international working groups US , UK , SWE , FIN and presentation of results in front of an international audience .. Technologies : SLS DLS",carriers;expression;screening
Production Data Scientist . Perform data analysis for production support and failure investigations Maintain and develop new tools data retrieving scripts and visual dashboards to expand company s SPT Statistical Process Trending program Maintain and develop Minitab macros for generating trend graphs with control limits based on historical data analysis . . Technologies :,
Staff Scientist . X ray crystallography Cryo EM protein Production Single domain antibodies nanobodies Phage Display . I come from a multi disciplinary background with 15 years scientific experience obtained in internationally renowned research institutes . I have published my research in highly ranked scientific journals and won awards at both European and International conferences . As both an independent research group leader and now as staff scientist I am accomplished at managing multiple projects and personnel and in developing new projects using cutting edge molecular and biochemical techniques . . Technologies : Xray;CryoEM,antibodies;proteins;interaction;structure
Associate Professor . . Structural studies of membrane proteins and protein complexes by cryo electron microscopy and X ray crystallography .. Technologies : Xray;CryoEM,membrane proteins;proteins;structure
"Integration Scientist 1 . . Experienced Systems Integration Scientist with a demonstrated skillset in Next Generation Sequencing Technologies , Product Development , Laboratory Robotics , Bioinformatics , Ad hoc and Reusable Data Tools Development , and Project level Data Management . I thrive in the grey area between product developmental teams to help identify and improve developmental gaps inefficiencies , increase multidisciplinary team communication and collaboration , and develop best in class sequencing technologies .. Technologies :",
"PhD Fellow . . Driven by the passion of doing science for a purpose . Protein biochemist and structural biologist with 9 years of experience working on various multidisciplinary projects with a focus towards pharmacologically relevant protein targets . Acquired extensive research experience in different labs around the world Asia , North America and Europe . Skilled in expression plasmid optimization , protein purification using the AKTA systems , structural determination using X ray crystallography and cryo EM , biophysical and biochemical analysis of protein function and interactions , data analysis and effective scientific communication . Highly passionate about working in the pharmaceutical industry with the end goal of contributing towards patient relief and effective prognosis .. Technologies : Xray;CryoEM",proteins;characterization;expression;interaction;structure
"Senior Bioinformatics Developer . Develop pipelines for bioinformatic analysis of high throughput sequencing data , databases for metadata management . . Gordon Brown passed away July 2021 . I am his sister , Lynn ; I have been unable to close the account so far but wanted to let people know that he is no longer available for jobs . Thanks , Lynn Brown . Technologies :",
"Senior Principal Scientist , Group Lead , Tranlational Bioinformatics and Sciences . . A highly self motivated computational professional with multi disciplinary expertise . Extensive experience on designing computational approaches and bioinformatics solutions to support translational programs in Rare , Neurological , Immunology Inflammatory disease areas . Strong expertise on applying data mining , machine learning , statistics and network approaches on large scale heterogeneous omics data integrative and predictive analysis for drug discovery . Led and supported for over 80 projects under different drug discovery and development stages in Sanofi Genzyme , including disease mechanism understanding , drug target discovery validation , target indication expansion , drug MOA , biomarker identification , patient stratification , and drug repurposing . Experienced on informatics tools system design and development . Author and reviewer of a number of publications on renowned bioinformatic journals , book chapters and IEEE conferences . Works have been reported by various public medias such as ScienceDaily and European Orphanews . Specialties : Translational Bioinformatics Computational Biology Data Sciences Research Informatics Natural language processing with text mining tools Programming skills on JavaScript , R , Perl , Python , SQL . Informatics tools design and development High performance and parallel computing Data Visualization . Technologies :",
"Senior Director of Process Development . . Areas of expertise include : . Product and Technical Support : . process of manufacture of existing and new products . new technology introduction , development , process improvements , GLP and GMP compliances . creation of study plans , SOPs required for manufacturing , production batch records and reports for product related activities . execution and assessment of process data and correction of production issues . R D and analytical dept . execution of developmental trials , design of experiments . process and technology transfer to multiple international partners . train operators and other personnel on new technologies . co ordination and organisation of large team of scientist for GLP studies . Quality Control : . lead process team investigations into failures out of specifications ensuring corrective actions are implemented . responsible for upholding departmental quality compliance standards . provide support and review process for validation documentation . Reporting and Communication : . generation and presentation of bimonthly progress reports and annual reports to CSO and CEO . assessment and cost analysis on processes and equipment . EU consortia meeting and conference presentations . Immunological techniques : Flow cytometry BD FACSCanto , Calibur , Aria II , Miltenyi MACs Quant and Tyto , mixed lymphocyte assays immunosuppressive and immunogenicity , MACS sorting , alloantigen recall responses , alloantibody assays , cytotoxic T cell assays , phagocytosis assays , ELISA , histology H E . Cell Culture techniques : Isolation , culture , cryopreservation and characterisation of primary cells and cell lines . Molecular Biology and Virology techniques : RT PCR , PCR array , cloning , Adenovirus and Lentivirus production concentration titration , cell transduction and transfection . In vivo techniques . Data Analysis : FlowJo , GraphPad Prism and Excel . . Technologies :",
"Scientist I . . Biochemistry Ph.D. scientist Lab Bench Skills : Protein preparation and purification , NMR , AKTA chromatography , chromatographic methods : metal affinity ; ion exchange ; size exclusion , SDS PAGE , DNA cloning site directed mutagenesis , molecular biology , Gibson assembly , mammalian cell culture , bacterial cell culture esp . E. coli , sterile technique , PCR , RNA isolation , rt qPCR , LC MS , computational biology , Illumina next generation sequencing NGS library preparation Software : NMRpipe , Python , MATLAB , Pymol , Excel , Microsoft Word Human Languages : English native , French advanced . Technologies : NMR",
"Instrument Scientist Lab Manager . At Bernal Bio Labs , I lead research on biopharmaceutical monoclonal antibody process development , and support cutting edge research through trouble shooting , data driven decision making , statistical design of experiments DoE , bespoke data visualization solutions R and Plotly , and simulation based upstream downstream process optimization using advanced statistical and multi physics approaches . . Additionally , I ensure that large equipment including bench top and pilot scale bioreactors Applikon and Eppendorf , fast liquid chromatography systems KTA Cytiva , HPLCs Agilent , and Mass Spectrometers are kept in functioning order . Finally , it is also my responsibility to ensure that the laboratory facilities are kept safe , organized , and well stocked . . I am a result oriented scientist and bioprocess engineer with a strong mathematical and statistical background , experienced in upstream and downstream biopharmaceutical process development , Quality by Design tools , statistical design of experiments DoE , and simulation based optimization . I have experience leading international research teams and I can speak English , German , and Portuguese fluently . After having concluded my B. Eng . Hons in Bioprocess Engineering and Biotechnology with the highest GPA of the year , I was awarded a competitive scholarship to pursue a doctoral degree at the prestigious Max Planck Institute in preparative chromatography simulation and optimization , which I concluded with highest honors Summa cum Laude . I was then awarded a highly competitive post doctoral fellowship at the University of S o Paulo to apply simulation and Quality by Design tools including Bayesian inference and Design Space mapping in the development of the biopharmaceutical anti leukemic enzyme L asparaginase for the Brazilian public healthcare system , during which time I also established cooperations with the Universities of Cork and Loughborough . I now work as instrument scientist lab manager of the Bio Labs in the Bernal Institute University of Limerick , where I lead cutting edge research on monoclonal antibody purification , Bayesian modeling of bio pharmaceutical processes , and simulation of mRNA vaccine production processes . Additionally , I support the research of the Bernal Bio Labs users through the statistical design of experiments , data driven decision making , data interpretation , and visualization , as well as simulation based optimization . Furthermore , I also ensure that the laboratory facilities are kept organized and safe , while also maintaining laboratory equipment in working conditions . . Technologies :",antibodies;biologics;screening
"Director Of Bioinformatics . . Experienced leader growing high performance teams , managing change , and working in a fast paced biotechnology industry . Strong research professional skilled in Next Generation DNA Sequencing , Bioinformatics , Data Science , and Biotechnology .. Technologies :",
"Director , Integrative Genomics and Bioinformatics Core . . Experienced Bioinformatics Analyst with a demonstrated history of working in the research industry . Skilled in the analysis of all types of nucleic acid sequencing , proteomics , and other high throughput quantitative technologies . Strong research professional with a Doctor of Philosophy Ph.D. focused on Quantitative Computational Biology from Princeton University . . Technologies :",
"Head of Bioinformatics . . Advances in medical technology has created opportunities for major discoveries in scientific medical research , and raised hopes for potential breakthroughs in diseases such as cancer . This ongoing progress has stirred up much excitement and anticipation among professionals in the medical and scientific research community , myself included By combining my leading edge knowledge and expertise in the areas of gene technology , computational genetics and genomics , and genetic epidemiology , with state of the art technology and methodologies , I have made significant headway in various stages of medical research . As the CTO of a genetic testing company , I have made leaps of progress in developing a wide range of cutting edge genetic testing products , focusing on personalized medicine , disease risk prediction , personalized nutrition , and inborn talents , including leading the research on the validation of warfarin pharmacogenetic algorithms through a recent publication . From a business management standpoint , my systematic , yet flexible approach to meeting challenges has enabled me to effectively engage in handling multiple concurrent projects , such as dissertations , publications , public presentations , patents , and working with interdisciplinary teams toward higher performance standards for enhanced accuracy , efficiency , and productivity . As a seasoned and confident communicator , I possess the natural capacity for bringing people together in achieving common purposes ; including cultivating a culture and environment that encourages , nurtures , and rewards excellence , while emphasizing team cooperation . It is thus with a healthy dose of optimism that I welcome opportunities for applying my cross functioning skills and abilities across a broad range of key roles , and developing mutually beneficial partnerships for advancing scientific and medical research , technological development , and business growth . Technologies :",
"Staff Scientist . Molecular Graphics Laboratory Department of Molecular Biology , MB 5 The Scripps Research Institute http : mgl.scripps.edu . After 3 years of studying in the university Paris 5 to earn my Doctoral , I acquired skills in molecular modeling , in particular the structural study of protein protein study , in order to develop new therapeutic agents for the blood coagulation disorder . I was in a position at the university Paris 7 for 2 years , combining teaching and research in the fields of macromolecular assembly at the structural level including the application of current methodology and development of new methods . I was a postdoc at The Scripps Research Institute TSRI in the Molecular Graphics Laboratory MGL , working toward a better interaction with macromolecules tangible interface , augmented reality , 3D rendering , etc . . I am now a staff scientist at The Center for Computational Structural Biology CCSB created in 2018 as a successor of the Molecular Graphics Laboratory . I am the lead developer of ePMV , cellPACK and cellPAINT . https : ccsb.scripps.edu http : epmv.scripps.edu http : autopack.org https : ccsb.scripps.edu cellpaint Specialties : bioinformatic , molecular modeling , molecular docking , molecular graphism . Technologies :",
"Research Fellow . . I am a computational biologist , with more than 10 years professional experience of high quality scientific research at the intersection of molecular biology , computer science and statistics . My current research activities predominantly involve the development and application of biostatistics and machine learning methods regression , classification , supervised and unsupervised learning to a broad range of molecular and clinical datasets . Specialties : Bioinformatics and computational biology ; NGS data analysis ; sequence analysis ; protein function prediction ; structural bioinformatics ; statistical data analysis ; machine learning ; design and analysis of algorithms .. Technologies :",
"Researcher Cryo Electron Microscopy , Brichos Domains , Alzheimers Disease . Department of structural biotechnology at School of Technology and Health Associated at KI Dept Bioscinence and Nutrition and Neurobiology , Care Sciences and Society . I started my career as a musician cellist . Due to scoliosis , I had to give up this profession , but I was lucky to be able to change into the exciting field of life science and electron microscopy . From 20170601 : Structural determination of the Bri2 BRICHOS domain Alzheimer s disease AD is a fatal neurodegenerative disorder , where amyloid plaques , manly from the amyloid 42 A 42 , accumulate in the brain . The Bri2 BRICHOS domain has a physiological role in delaying A 40 and A 42 fibril formation and toxicity in vitro and in vivo . The anti amyloid chaperone activity of Bri2 BRICHOS makes it a promising treatment strategy for AD . The aim of the project is to obtain high resolution structural data from the Bri2 BRICHOS domain . Collaborators : Jan Johansson , Center for Alzheimer Research , KI ; and the group of prof . Hans Hebert , Department of Biosciences and Nutrition , KI , and School of Technology and Health , KTH Royal Institute of Technology , Novum , Huddinge . Novel 3D electron density maps are recently obtained . Further structural studies via high resolution single particle and cryo electron microscopy techniques will be performed . 2010 20170531 : Molecular structure , packing and release of gelforming mucins with relevance to Cystic fibrosis In many diseases , such as different inflammations in the airways and intestine , the expression of mucins is altered . In CF an extremely viscous fluid is built up . Understanding the N terminal calcium and pH dependent mechanisms of packing and secretion of mucins may be helpful in designing novel therapeutics . Collaborators : Gunnar C. Hansson mucin biology group , University of Gothenburg , Sweden ; the group of Hans Hebert , Karolinska Institutet KI and School of Technology and Health , Royal Institute of Technology , Huddinge , Sweden , Novel 3D electron density maps were recently obtained for all gel forming mucins . . Technologies : CryoEM",idps;structure
"Scientist Immunology and Microscopy . Assay development , Characterization and validation of engineered therapeutic antibodies , In vitro functional assays Eg . ADCC , CDC . . Dynamic and ambitious professional with 10 years of experience in research and life science industry in bioassay development and quality control . I m highly organised and skilled in building up cross functional teams . Colleagues describe me as well organised , reliable and efficient co worker . In my free time , I teach Yoga for beginners . Administrative and Quality : Project management , Creative and problem solving , technical report writing Industrial production and quality control : cGMP , SOP , QMS , ISO 13485 , regulation and guidelines . Technologies :",antibodies;characterization
"Senior Chemist . Support for filling and freeze drying process team , Aseptic Production Class A B facility . Work with deviations , CAPAs and change controls related to products and processes . Write standard operating procedures SOP , work instructions WIN , production documentation master formula production formula . Aseptic process simulation APS . Process optimisation projects , single use materials , cleaning monitoring and trending , APS strategy , product and process risk assessments . . Specialties : Aseptic filling of vaccines Class A B facility , freeze drying , APS , risk assessment , trending . API Production of biological diverse products for immunotherapy , unit operations , PQR , CPV , deviations , change controls , production documents , equipment qualification . Synthetic organic chemistry , Parallel chemistry , Drug discovery , Hit to lead optimization , Medicinal chemistry , Lead optimization of small molecules , GPCR nuclear receptor targets within CNS , nephrology and dermatology , Evaluation of IP space , EHS , Coordination of research outsourced to CRO . I am author co author of 15 publications and 6 patent applications . Technologies :",
"Statistics consultant . Biostatistics consulting and teaching for pharmaceutical and biotechnology companies in clinical trials , molecular diagnostics , medical devices and drug development . My work has led to FDA and CLIA approvals , articles in the New England Journal of Medicine and in Lancet , many patents , and products with several hundred million dollars in revenues . Biostatistics consulting for venture capital companies to evaluate investments in life sciences . Work with life science start ups to obtain funding . Advise on corporate strategy and product development . . Statistics consulting for clinical trials , pre clinical studies and basic research in pharmaceuticals , diagnostics , and devices .. Technologies :",
"Director of Bioinformatics . Developed Next Generation Sequencing NGS bioinformatics pipeline infrastructure for clinical diagnostics . Developed custom software for variant filtering , annotation and interpretation support . Supervised bioinformatics production . . Self driven , goal oriented bioinformatics software developer , data analyst , systems integrator and technology strategist with passion for detail and quality . 18 years bioinformatics group leadership management mentoring and infrastructure planning and implementation . 7 years Next Generation Sequencing data analysis and software development Bash , Java , Scala , Perl , Python . 18 years bioinformatics analysis and application of biomedical databases NCBI , UCSC , HGMD , OMIM , etc . . 27 years data analysis and analytical software development C , C , Java , Scala , Perl , Python , VBA , MATLAB , R . 16 years laboratory database and information system development MySQL , MS SQL Server , MS Access . 12 years research manuscript and grant authoring , and internal and external results presentation . 6 years development and management of SOPs and documentation for CLIA and CAP certification .. Technologies :",
"Manager , Application Scientists . . I am an Applications Engineer Life Sciences with expertise in Cryo Electron Microscopy . I am also a Structure Biologist with an interest in virus structures , virus receptor and antibody interactions and cell entry . My main interests include structure based vaccine design , epitope mapping , antivirals , virus receptor interaction and cell entry using high resolution CryoEM , FIB milling and Electron Diffraction , X ray crystallography , among others . . Specialties : Structural biology , Cryo electron microscopy , X ray crystallography , microED , molecular biology , biochemistry , protein structure and function , molecular graphics . Google Scholar : Abhay Kotecha . ORCID : 0000 0002 4480 5439 . Research gate : Abhaykot . Technologies : Xray;CryoEM",
"Graduate Research Fellow . Awarded the National Institute for General Medical Sciences NIGMS Initiative for Maximizing Student Development IMSD Fellowship at UCSF . IMSD is designed to support historically underrepresented and marginalized PhD students in basic science graduates programs . Currently performing a summer rotation as a Biological and Medical Informatics PhD student . . I am PhD Student at University of California San Francisco and I have a diversity of work experience that makes me particularly well suited to a variety of research or technological support positions . While on the job , and in my studies , I have learned the value of building trusted relationships with both team members and customers alike . Additionally , I approach every professional encounter with a high level of curiosity , positivity , and fervor for finding robust solutions . I have extensive experience delivering service : over the phone , remotely via network , in store , and without managerial oversight . Ultimately , I attribute my technical insight and research abilities to the extensive training I received under my mentors from leading academic institutions and to my personal dedication to understanding the world around us . I believe I would make a great addition to any team as I have a genuine interest in serving people and in finding ways for advanced knowledge to benefit us all .. Technologies :",
"Assistant Research Professor . . Experienced Assistant Research Professor with a demonstrated history of working in the higher education industry . Skilled in Materials Science , Transmission Electron Microscopy and Cryo Electron Microscopy , Nanotechnology , UV Vis Spectroscopy , and Powder X ray Diffraction . Strong research professional with a Doctor of Philosophy Ph.D. focused in Materials Chemistry from the University of Minnesota Twin Cities . . Technologies : Xray;CryoEM",
PhD Student . . . Technologies : CryoEM,
"Lead Scientist Research Development . Omics tecnologies for BioPharma . A highly self motivated and passionate Ph . D chemist with strong expertise in bioanalytical methods development , employing state of the art techniques : hyphenated chromatography mass spectrometry HPLC , UPLC , GC , MS and MSn using single and triple quadrupole MS , ion traps , Qq Tof , orbitrap for omics technologies in the fields of biology , chemistry and cultural heritage . I am currently working as lead scientist at Lonza Pharma Biotech applying LC MS based technologies for the characterization of biomolecules including protein therapeutics that continue to dominate the global pharmaceutical market and to grow significantly in the last few years . Turning academic ideas into commercial concepts , I am using top down , bottom up and middle down methods for enhanced protein characterization in terms of sequence determination , post translational modifications PTMs and higher order structure HOS analysis . Improvements in MS instrumentation along with improvements in ionization and dissociation methods that lead to high throughput high resolution MS based methodologies consist my main field of interest . During my undergraduate postgraduate studies I focused and specialized on : Proteomics Top down Bottom up proteomics Method development for protein extraction purification Liquid Liquid techniques , S trap , SPE columns , affinity resins Development of innovative kits with extremely high sensitivity for characterization of proteinaceous materials Protein characterization and quantitation by UV Vis spectroscopy , size exclusion hydrophobic interaction ion exchange chromatography , HPLC and LCMS Protein degradation with the investigation of Post Translational or chemical modifications with the use of bioinformatic tools Study of biochemical pathways Small molecule analysis Metabolomics Isolation and structure elucidation of secondary metabolites from natural sources or biological sources Development of analytical protocols for molecule extraction and latter characterization by mass spectrometry LC MS MS , GC MS or spectroscopic methods FT IR , Raman Development of UHPLC and LC MS methods for the quantification of small molecules in biological fluids or natural sources Validation of analytical methods according to the guidelines of FDA or EMA Pharmacokinetic studies in Natural Products Organic chemistry for drug design Techniques of organic synthesis and catalysis Isolation and purification of organic compounds by chromatographic methods Identification of organic compounds by NMR , GC MS , LC MS and FAR IR .. Technologies : NMR",biologics;characterization
"Senior Scientist . Cell culture process development for expression of antibody mixtures that address multiple oncology targets in a single drug product . API coordinator . Project management and tech transfer to CMOs . Cell line generation , cell banking and upstream process development Process characterization and validation . Leading upstream process characterization study design . Regulatory filing , Module 3 Six Sigma black belt statistics : QbD , DoE , predictive modelling . Toolbox : JMP Pro , Python . Scientific Data Management System built with Azure Databricks . Responsible for automation scripts Python , PySpark , SQL and scientific data management strategy across CMC area . . Experienced in Cell line generation , upstream and downstream process development , tech transfer and manufacturing . Subject matter expert in CMC process data science , DoE and applied statistics . Data Science in the CMC area scientific data management system owner and project leader . Spearheading automation of data processes and statistical analyses across several scientific areas ; lab automation , data wrangling , visualization and predictive modelling . Toolbox : JMP Pro , Python , SQL , Azure , Databricks . API coordinator Project management and tech transfer to CRO CMOs . Regulatory filing , IND , BLA Six Sigma Black Belt statistics . DoE approach to process development and statistical process control for manufacturing . Cell line generation and cell banking Upstream and downstream process development and manufacturing . Process characterization and validation . Leading upstream process characterization study design , execution and reporting .. Technologies :",
"Postdoctoral Research Fellow . . My long term research goal is to explore molecular drivers of disease at the interface between structural biology , biophysics , and biochemistry . Specifically , I aim to investigate the structure of disease related protein complexes to inform cellular studies and functional assays that guide drug development . In my graduate work , I combined structural biology , protein chemistry and biochemistry to explore the intricate interactions between chromatin binding proteins and the nucleosome , the fundamental repeating unit of chromatin and a robust regulatory hub that modulates the activity of numerous nuclear proteins . These transient interactions are frequently misregulated in cancer , and essential binding surfaces at these interfaces present an exciting opportunity as new therapeutic targets . My postdoctoral research has expanded my skillset into the field of membrane proteins , in which I combine single particle cryo EM and cryo ET with single molecule biophysical techniques to investigate the native architecture and arrangement of AMPA receptors , essential excitatory neurotransmitter gated ion channels that contribute to tumor growth and invasion in brain cancer . Research specialties : Cryo electron microscopy single particle cryo EM and cryo ET Confocal laser scanning microscopy LSM High performance liquid chromatography HPLC Fluorescence detection size exclusion chromatography FSEC Protein expression and purification recombinant and from native tissue Characterization of protein protein interactions using single molecule and population based biophysical assays Biochemical characterization of enzymatic activity Molecular biology 3D printing protein structures and other useful lab items Publications list : https : orcid.org 0000 0003 2334 3957 Outside of the lab , I love doing anything outside but especially playing soccer , hiking , and backpacking , music violin guitar , and travel .. Technologies : CryoEM",nucleic acids;proteins;characterization;interaction;structure
Research Specialist . . . Technologies :,
"Associate Scientist Target Discovery . Identify and characterize novel disease relevant targets in the following areas : . osteoarthritis , rheumatoid arthritis , polycystic kidney disease . Scientific responsibilities Develop phenotypic assay models ; perform , analyse and report experiments ; scientific literature research . Key Techniques Technologies : Fluorometric , luminescent and colorimetric readouts ; Protein quantification ELISA , MSD ; Immunocytochemistry ; mRNA profiling qPCR , QuantiGenePlex ; Cell culture . . . Technologies :",proteins;small molecules;characterization;screening
Computational Chemical Biologist . . . Technologies :,
Senior Principal Quantitative Scientist . . . Technologies :,
"Bioinformatics and Data Science Analyst Consultant . project based bioinformatics analysis , support , and engineering currently an RNA seq , circularRNA circRNA , pathway analysis , scRNA seq cancer normal cell classification . Software Bioinformatics Engineer interested in growth opportunities : bioinformatics , software engineering , info . security assurance , Machine Learning . 10 years bioinformatics support in Govt . Academic settings . Specialties : BioInformatics . Technologies :",
"Researcher . David Liu Lab : Evolution of biochemically optimized orthogonal transacting inteins . Molecular dynamics MD investigation of spCas9 biotechnologies . . I am fascinated with leveraging the physics and chemistry of biomolecules to engineer molecular biotechnologies . As a junior at MIT I am majoring in chemistry and computer science and minoring in physics . This integrated scientific toolkit allows me to investigate biomolecular systems from a first principles approach and tailor computational methods to address new challenges arising in the fields of computational chemistry and biology . For example , after entering college I discovered molecular dynamics MD which is a computational chemistry technique that allows me to simulate high molecular weight proteins and investigate conformational dynamics at an atomic level of detail . I have since used MD in the David Liu Lab to develop models of CRISPR Cas9 therapeutic activity based around recognizing previously undiscovered details of Cas9 s conformational dynamics . In addition to physical chemistry I am interested in understanding evolution as a process for generating immense diversity in the function of biomolecules from functionally distinct starting material . In particular I am inspired to direct the evolution of proteins utilized in genome modification to select for precision and selectivity in their activities .. Technologies :",
Research Associate . . Cryo electron microscopist with 5 years of experience in cryo electron tomography of cells and tissues . Passionate about structural biology of macromolecular machines that are vital of sustaining life with a special focus on elucidations of their structures in their native context . Believe such studies will be of enormous help regarding future drug design . Technologies : CryoEM,proteins;structure
"Lab Manager Protein Purification . . Protein biochemist with a background in protein expression , purification and biophysical characterization of proteins and protein complexes . Thorough knowledge of high throughput methods applicable in protein science , as well as specialized approaches for more challenging proteins .. Technologies : BLI",proteins;characterization;expression
"Senior Scientist . Computational Proteomics , Bioinformatics , Mass Spectrometry based Proteomics . bioinformatics , proteomics , computational biology . Technologies :",
Associate Professor . . Cryo electron microscopy Marcomolecular Crystallography Structural Biology Membrane Proteins . Technologies : CryoEM,membrane proteins;structure
"Senior Bioinformatician Proteomics . . I am an experienced bioinformatics researcher with a demonstrated history of working in the area of mass spectrometry based proteomics and multi omics , like genomics , transcriptomics , metaproteomics , etc . I have recently earned my Ph.D. degree from the University of Minnesota . As part of my Ph.D. , I worked to address the issue of large protein sequence databases that we often encounter in a proteogenomics and metaproteomics data analysis . Also , developed several multi omics tools and workflows for the Galaxy Platform . I am actively contributing to the Galaxy community towards providing an accessible platform with tools and workflows for bioinformatics research . I am involved in developing and wrapping new tools and workflows , as well as wrapping existing bioinformatics tools to make it accessible through Galaxy . Additionally , I have also contributed to Bioconda by submitting Conda recipes for existing bioinformatics tools for easy dependency management . Skilled in Python , Perl , R , Bioinformatics , Genomics , Proteomics , Transcriptomics , Workflows . I have been in bioinformatics for 15 years now including my Bachelor of Science B.Sc . degree from India and Master of Science M.Sc . from India , 4 years of working experience in research academia focused in Bioinformatics , Master of Science MS degree focused on Bioinformatics and Computational Biology from the University of Minnesota , and Ph.D. focused on Bioinformatics tool and workflow development on Galaxy for Proteogenomics , Metaproteomics , and Quantitative Proteo Transcriptomics . . Technologies :",
"Scientist . . Doctorate in Biochemistry with over eight years of analytical development and research experience . A productive and driven independent scientist that has strong technical writing skills and six publications . Advanced experience developing assays and analyzing amyloid protein interactions with small molecule drug targets , cholesterol , and liposomes through separation and spectroscopic techniques . Collaborated with other laboratory teams to solve complicated questions that led to scientific breakthroughs . Mentored junior scientists to be proficient leading to stronger collaborative teamwork and productivity . Detail oriented , organized , and solves difficult problems in a timely manner . Laboratory Skills and Techniques : Research , titrations , reflux , recrystalization , pH meters , buffer preparation , pipettors , analytical assay development , peptide protein synthesis , peptide protein purification and monomerization , gold nanoparticle synthesis , quantum dot synthesis , liposome preparation thin film hydration and extrusion techniques , peptide protein biophysical characterization , and inhibition quantification assays of peptide aggregation kinetics . Instrumentation : High performance liquid chromatography HPLC , mass spectrometry MALDI , FTIR and ATR , Raman , UV Vis , fluorescence and plate readers , atomic force microscopy AFM , dynamic light scattering DLS , circular dichroism CD , peptide synthesizer , and nuclear magnetic resonance NMR spectroscopy . Software : Origin , Gaussian , MFP 3D AFM software , Malvern Zetasizer , Agilent HPLC ChemStation , flexControl Voyager MALDI , ChemDraw , EndNote , and Microsoft Office Word , Excel , and PowerPoint .. Technologies : SLS DLS;CD;NMR",idps;small molecules;characterization;interaction;screening;stability
"Bio process developer Researcher DSP . Intravacc is an Institute of Translational Vaccinnology . Intravacc has a long history in developing vaccines . It promotes public health by developing vaccines from the laboratory to clinical study in man . To achieve this mission , our aim is to substantially reduce development risks and costs of new vaccines by bridging the translational gap between laboratory bench and market so in other words the gap between vaccine research done at Universities or sme 's and Industry . My work includes . Screening and setting up new processes for candidate vaccines , ranging from initial proof of concept using gradient cetrifugation , till scalable processes using more modern technologies . Volumes range from 1 . 5L till 100L. Setting up and implementation of a liquid handler for assay execution and HTPD work under BSL 2 . Screening new and old technologies for their potential use in processes and optimizing troubleshooting individual process steps . Optimizing a viral vaccine candidate and producing another viral candidate under GMP . . To paraphrase a bit I love to solve a problem wrapped in a mystery inside an enigma using modified old , current or experimental techniques and thrive at it . I currently work both on a farm dairy and in the pharma . My expertise lies with process development and purification DSP Downstream Processing both bacterial 1000L mammalian 1500L based . Scale up , scale down , intensification , troubleshooting optimization of production processes . All integrated with : Design of Experiment DoE , Quality by Design QbD , High Throughput Process Development HTPD , innovation techniques e. g. TRIZ , Lean for Six Sigma Green Belt , and Statistical Process Control SPC . Up to the GMP production of Clinical Material at maximum biosafety level 3 BSL 3 and transferring receiving processes to partners . Good theoretical knowledge of USP , cont processing . I modernized our current DSP lab facilities equipment and brought them into the 21st century and ready for beyond and was involved in the startup of a BSL3 vaccine production facility . Techniques include not limited to . Clarification NFF , centrifugation , precipitation flocculation , nano . Concentration CFF TFF , UC . Chromatography column , membrane , monolith . Inactivation Chemical , UV , thermal . Supporting laboratory infrastructure . Participating in qualification validation of equipment and process . My personality is best described by the acronym INTJ . I do not shy away from a challenge and have been involved in multiple successful court cases against the government , and recognized as a vaccine production safety expert . I 'm enthusiastic , driven , flexible , creative can think way outside of the box what box plunge in and do what is necessary , give 100 and continuously expand my skill set to overcome challenges presented . This led to several participations in scientific publications patents trade secrets conference participation presenting , oral , and posters . Due to my broader pharma biotech interest have a good overview of the current state of art , industry and can expand on it . Vaccines are a form of endogenous antibody therapy and the most complicated , widely available , cheapest biopharmaceutical with the highest possible safety built into them . There is indeed a small uncertainty on vaccines , but just because they can not deliver 100 safety , given how serious the disease risks are including a far higher risk from the actual virus , this is not a reason to not continue using vaccines . . Technologies :",biologics;expression
Bioinformatics Scientist . . . Technologies :,
"Bioinformatics Scientist . . Dr. Holman is a computational biologist with experience designing computational pipelines that apply machine learning , network modeling , statistical , and pathway analysis algorithms to mine high content datasets , including genetic , genomic , next generation sequencing and clinical data , to facilitate new drug target identification and development of genetic signatures applicable to patient stratification and diagnosis . He is experienced in both industry and academic settings , focused on drug discovery , translational medicine , and systems biology , with specific expertise in the neurobiology of HIV replication , and in silico selection of novel drug targets . He is fluent in general purpose programming and analysis languages including Perl , R and SQL , as well as domain specific analysis tools , such as Cytoscape , Hyphy and TopHat Cufflinks . Additionally , in the course of his work he has designed and implemented large SQL databases , both to facilitate in house research , and for deployment of the publicly available HIV Brain Sequence Database .. Technologies :",
"Sr . Director , Head of Translational Bioinformatics . . . Technologies :",
Data Science Manager Machine Learning Group Lead . . . Technologies :,
"Researcher PHD Student . . PhD student in structural biology using single particle analysis cryo EM to study viral polymerases . Dabbled in electron cryo tomography of viruses , nanodisc embedding and membrane proteins .. Technologies : CryoEM",membrane proteins;structure
"Principal Scientist . . Broadly trained and experienced Senior Scientist with more than 19 years of Pharma experience Experienced in laboratory management with proficiency in expression profiling by real time PCR , assay development , cell biology and antibody generation . Experienced project team representative with business writing , data presentation and project management skills . Confident , efficient , work independently and as a team player , willing to take on new challenges and acquire new skills . Technologies :",antibodies;developing
"Senior Scientist . . Accomplished and intuitive scientist who offers comprehensive experience in preformulation , formulation , product development and manufacturing Equipped with expertise in material properties , formulation development and manufacturing Apply cutting edge techniques to solve the problems Operate in a strong sense of urgency and thrives in a fast pace setting Area of Expertise : Preformulation form screen and selection Formulation and process development Amorphous formulation Continued process verification . Technologies :",formulation
"Postdoctoral Scientist . . I am a biochemist with 10 years of expertise and understanding of protein production , stability and structure with a focus on developing better drugs and therapeutics . I have received the EMBO Long Term 2 year grant for my current project . My current area of interest is the molecular organisation and interactions of transmembrane receptors that determine signalling events at the surface of immune , cancer and neuronal cells . I am a skilled project manager and a bench scientist with excellent command over scientific fundamentals and have a broad working knowledge . I am a specialist in a number of approaches , particularly mammalian cell culture ; High throughput biophysical assays including SPR , MST , BLI ; flow cytometry ; protein structure analysis ; protein purification and molecular biology techniques cloning , transfection , quantitative PCR , bio assay design optimization and small molecule drug discovery . I have key strengths in establishing collaborations , problem solving , independent thinking , thoughtful and careful execution of experimental work , ability to work on multiple projects in teams , developing daily work plans and keeping up to date with literature . I have written several research grants and international publications . I also possess great interpersonal , management , written and oral communication skills .. Technologies : BLI;SPR;MST",membrane proteins;expression;interaction;screening;stability;structure
"Principal Scientist . Principal scientist in BMS Infectious Diseases focusing on the discovery and development of antiviral therapeutics . Research efforts in my group are focused on the discovery and development of small molecule antivirals directed against multiple pathogens including HCV , HBV , Dengue and BVDV . Experienced in all stages of drug discovery from target selection to clinical nomination and first in human studies . In particular , played a key role in the discovery and advancement of HCV NS5A and NS5B inhibitors Daklinaza and Beclabuvir , including screen development , high throughput screening , target identification , mechanism of action studies and advancing leads through compound profiling and Phase 1 clinical studies . Expertise includes cellular and molecular biology , small molecule mechanism , biochemical and cell based assay development for compound identification and triage , biochemistry , genetics , and small molecule drug discovery process . . Technologies :",proteins;small molecules;screening
"Postdoctoral Researcher . Project : Alkylsodium reagents for organic synthesis in continuous flow . Continuous flow sodiation of benzylic and allylic C sp3 H bonds done with on demand generated hexane soluble alkylsodium base using a sodium packed bed reactor . Extreme nucleophilic nature of benzylic sodium species led to highly selective and efficient cross coupled products with alkyl chlorides and ring opening products with epoxides , oxetanes and aziridines . Developed a concise and sustainable synthetic route to Fingolimod Gilenya oral drug starting from commercially available p xylene with an overall yield of 45 . Efficient , passionate and purpose driven researcher with over 10 years of experience in organic synthesis and catalytic method development , continuous flow chemical synthesis , photoredox , small molecule drug discovery , medicinal , green organometallic and supramolecular chemistry . As a result oriented researcher , my passion and problem solving skills have resulted in over 11 publications in reputed journals including first authored high impact publications in JACS and Angewandte Chemie . As a lead author , I had proposed , designed and executed these projects which also reflects my skilled expertise and in depth knowledge in synthetic organic chemistry . . Working across laboratories in India , Hong Kong and Germany , I am highly adaptable collaborative and have strong teamwork , communication and networking skills . I have excellent standards of oral and written scientific communication skills as evidenced by the coveted Humboldt fellowship award along with several poster , oral presentation and travel grant awards in conferences across the globe . My leadership and mentoring skills were honed by supervising graduate and intern students towards project completion . . As a person constantly striving for innovative chemical solutions , I have worked in different areas of organic chemistry such as metal catalysis , asymmetric catalysis , supramolecular metal catalysis , highly reactive organometallic reagents in automation , photo catalysis and drug discovery research . Outstanding practical knowledge of product synthesis , purification and characterization skills . Expertise in multi step synthesis of small complex molecules . Skillful in purification methods : Flash column chromatography , crystallization , distillation and prep HPLC along with purity profile analysis of samples by GC , Chiral GC , LC MS and HPLC . Mastered sample characterization by NMR , Mass , FT IR , UV Vis Spectroscopy and Optical rotation . Expertise in packed bed reactor assisted highly reactive organometallic reagents synthesis in continuous flow . Experience in glove box and Schlenk line techniques to handle air sensitive compounds . Kinetics mechanistic studies , Isotope labeling experiments . Proficient with chemical databases such as SciFinder , Reaxys , and softwares such as ChemDraw , MNova , TopSpin , Origin , Mercury , EndNote . Email me at annapureddyraj gmail . com . Technologies : NMR",
"Amgen Scholars Senior Program Leader . Review applications and select participants Host and implement programming events Lead face to face meetings with three mentees Lead a team of program leaders to design programming . I am a student at Stanford University pursuing a Ph.D. in Biophysics . I find intracellular pathogens and how they interact with host metabolism very interesting . My other interests include life science venture creation , consulting , and patenting . Twitter : techmobio . Technologies :",
"Bioinformatics Scientist and Team Lead . . Experienced bioinformatics scientist with training in both dry lab and wet lab . Practical experience in protocols to generate sequencing data , applied statistics to design analysis pipelines , and web development tools to visualize results . In depth knowledge in ontologies and protein function prediction , as well as sequence analysis from multiple platforms and different types of experiments . Natural problem solving skills , and careful attention to details with creative and collaborative personality . . Technologies :",
Research Computing Analyst III . . . Technologies :,
"Postgraduate Fellow . Postgraduate fellowship in Francesca Coscia 's Lab https : humantechnopole.it en research groups coscia group applying biochemistry , biophysics and cryo EM to study thyroid biology . . . Technologies : CryoEM",proteins;characterization;structure
"Research Associate . . Khamal Kwesi Ampah holds a position as a Graduate Teaching Assistant in the University of Sheffield Biomedical Science Department . He is a PhD student in the same department and expected to graduate on 01 10 2016 . He has trained and supervised approximately 400 undergraduate students in basic laboratory techniques , cell and molecular biology . Khamal s experiences range from cell culturing , molecular cloning technique , signal transduction research Co Immunoprecitation and Western blot , immunofluorescence microscopy , protein purification , mass spectrometry to microbiological assays . Khamal is a team player . He was a member of immuno oncology team that developed an oral mucosal cancer vaccine business plan during a one week innovation summer camp organized by Merck Serono Biopharmaceutical Company , Darmstadt , Germany in July , 2014 . In addition , together with a team of five researchers , we presented a business plan on drug discovery with our hypothetical company named INNEUROTOX with a mission to target chronic inflammatory pain and transform lives through the discovery and commercialization of novel safer painkillers . Khamal is innovative , passionate , trustworthy , hard worker and has received several scholarships . He is a recipient of a three year University of Sheffield Prize Award with annual stipend of 16000 and free tuition fee . His current research focuses on the role of SNARE proteins in post Golgi trafficking and their relevance in antibody production . He also received a four year Ghana and China government scholarship to study Mandarin and MSc . Cell Biology in China , where his project focused on the molecular mechanisms underlying cancer cells migration . He is willing to relocate and has experienced different cultures . Khamal is self driven and productive . He is a co author of six peer review papers . He has given several talks and poster presentations . Khamal has interest in developing therapeutic drugs against cancer . Technologies :",
"Vice President , Research . I have the privilege to lead 80 of the best scientists to maximize the benefit people can get from the human genome . Our participant centric genetics research program drives : Target identification and validation to feed our therapeutic development program Our research collaborations with academia and industry R D for our consumer health and ancestry products We strive to do the best science , with the consumer at the heart of everything we do . . Experienced leader who loves science , scientists , and sharing science with colleagues , collaborators , and consumers . Specialties : genomics , genetics , scientific communication , product development , research regulations , data privacy .. Technologies :",
"Marie Sk odowska Curie Individual Fellow . . Experienced researcher with a track record of quantitative interdisciplinary work at the crossroads of physics , biology , applied mathematics and social science . Proficient in bringing together diverse computational and experimental methodologies to tackle complex problems . Skilled in agent based and individual based mathematical modeling , analysis of large multidimensional datasets , image processing , machine vision , natural language processing , network analysis , social media api . Current areas of interest include data science and big data , risk assesment , city analytics , remote sensing , computational social science , mathematical and computational biology .. Technologies :",
Salk Fellow Principal Investigator . . . Technologies :,
"PhD Graduate . Laboratory : Cibles Th rapeutiques et Conc ption de M dicaments CiTCoM Therapeutic Targets and Drug Design Eng Universit Paris Cit ex Paris Descartes Description : Development of an integrative molecular modeling solution to predict biomolecules 3D structures with significant implication for drug discovery field . The strategy aims to steer model to its target structure along a molecular modeling simulation implementing experimental structural data SAXS intensity . Domain : Molecular Modeling , Structural Computational Biology and Bioinformatics Hard Skills : Python , Fortran 90 , Bash Linux shell , LaTeX High Performance Computing Optimization of force field parameters Structural experimental data treatment : SAXS , X Ray Crystallography , NMR , Cryo EM , Chemical probing SHAPE Method of simulation : All Atom and Coarse Grained Molecular Dynamics Implicit and Explicit Solvant Enhanced Sampling Techniques : Temperature Replica Exchange Molecular Dynamics T REMD Normal Mode Analysis NMA Soft Skills : Communication and Vulgarization of highly technical topics Working with multidisciplinary teams . I am passionate about how fast artificial intelligence is taking root in the pharmaceutical industries and medical fields . More than ready and motivated to take up the challenge of applying such innovative approaches to drug discovery and development . Relying on my versatile profile from molecular modeler , structural biologist and biochemist perspectives , I have developed adaptability skills to resolve cross functional issues . I have demonstrated strong verbal communication skills through participation to congresses , teaching and supervising missions .. Technologies : Xray;CryoEM;NMR",
"Computational Biologist Principal Scientist . I work in a preclinical optical microscopy team focusing on image analysis workflows supporting drug discovery programs . This is part of the Lab Operations team , which broadly supports the Neuroscience Pain Research Unit programs across all disease areas of interest . The primary goal is to enable project teams to accurately and efficiently quantitate pre clinical microscopy data to drive robust decisions around target mechanisms and validation , compound effects , biomarkers and assay development . I work within a large matrix environment , collaborating across multiple groups including discovery biology , preclinical imaging , research statistics , and informatics . In this role , I analyze experiments employing various optical microscopy and video imaging modalities . Additionally , I implement and apply innovative image analysis methods and develop algorithms to analyze complex , multi dimensional images to help drive data driven drug discovery and development decisions . . . Technologies :",
Doctoral Candidate . . My name is Nate Burman . I am a graduate of Carroll College with a degree in Molecular Biology Biochemsitry and a Chemistry minor . I received my Masters of Science from Montana State University and I am currently pursuing a Ph.D. focused on biochemistry structural biology in Blake Wiedenheft 's Lab . My current work is centered on using combined Cryo Electron Tomography and Single Particle Analysis to develop visual proteomics models of macromolecular complexes within whole cells .. Technologies : CryoEM,proteins;structure
Transition Lead for Computational Biology Core . Managing the transition from the London Research Institute to the Francis Crick Institute for the Bioinformatics and Biostatistics Facility . . Technologies :,
"Senior Bioinformatics Scientist . Developing bioinformatics algorithms for molecular diagnostics , specifically biomarker assay and platform development , that leverage genomic and cell free DNA , in the domains of oncology , and organ health . . Bioinformatics Scientist working on problems in precision medicine leveraging genomics and transcriptomics , in the domains of oncology and organ transplant . Prior experience includes working in evolutionary bioinformatics , proteomics , systems biology , biophysics , graph theory , applied machine learning , deep learning , and quantum computing .. Technologies :",
Graduate Student . . Currently plunging into Cryo EM ; . Technologies : CryoEM,structure
"Research Director with the National Fund for Scientific Research . . Erik Goormaghtigh received a master degree and a PhD in chemistry from the Universit Libre de Bruxelles . After a two year post doc at UNC Chapel Hill , North Carolina , dedicated to the study of an ATPase , he received a position with the National Fund for Scientific Research , Belgium . He is now Research Director with this institution and Professor at the Universit Libre de Bruxelles . Since the late eighties , he developed infrared spectroscopy for the study of membrane proteins and lipids . Protein structure , orientation of secondary structure elements in the membrane and dynamics through H D exchange kinetics have been extensively investigated by infrared spectroscopy with the goal of understanding the minute conformational modifications that are responsible for transport activities . More recently , FTIR tools and FTIR imaging were developed in his laboratory for cell typing in cancers , antitumor drug modes of action and cell type sub type identification on cancer histological sections . He is the author of about 170 publications mostly related to infrared spectroscopy of biological membranes , proteins , cells and tissues . Technologies :",membrane proteins;proteins;structure
"Scientist 2 . VAE , CNN , Cryo EM , Data analysis using pandas . . Technologies : CryoEM",
"Director . 2022 present : Director , Biology Lead Protein Aggregation , Folding Clearance , H. Lundbeck A S Responsible for the scientific strategy within the Biology area Strategic support to Research Project leads and Biology Leads in linking biology to indication Secure knowledge transfer between projects within the area Represent projects within the area at upper management meetings Key driver for Business Development interactions within the area Evaluation of external research projects company assets Establishment and maintenance of external scientific collaborations Key contact person for scientific questions relating to the area As member for Next wave Forum in Lundbeck Research select and recommend explorative research activities and define critical path towards becoming a drug discovery project Daily scientific and people management of 2 Principal scientist , 1 technician , co supervision of PhD students . Twenty seven years experience in Drug Discovery within the Pharmaceutical Industry . Preclinical Research support to the development of new potential treatments of diseases in the central nervous system , in particular the Neurodegenerative diseases , Parkinson s disease and Alzheimer s disease . Extensive knowledge on the full value chain in Drug Discovery from Research to Marketing through work in Lundbeck s overall Strategy Team for Parkinson s disease and participation in cross functional talent groups . Nine years 1999 2008 experience in direct project management of multinational , cross functional research projects from target finding validation in vitro and in vivo to identification of a small molecule ready for clinical trials . Fifth teen years of experience , as head of department , in scientific and people management department sizes from 20 40 people . Current group from 2022 consist of 2 senior scientists , 1 technician , 3 associated PhD students . Five projects delivered to clinical development during this period . Management of external scientific collaborations with academic groups typically 10 15 collaborations . Twelve years experience in evaluating external assets 35 40 per year in collaboration with Business development Hands on experience in establishing cell based assays with disease relevant phenotypes endpoints and using these for target finding , target validation and profiling of efficacy of new potential drug candidates . Portfolio management . Chaired the Parkinson s Disease Team in Lundbeck Research for 5 years 2006 2010 . Therapeutic Biology Lead for Parkinson s Disease 2018 2020 . Main responsibility was to translate company strategy into specific research activities within Parkinson s disease and manage the activities during the early phases of drug discovery . Member of the Next wave Forum in Lundbeck Research 2018 overseeing early research activities and defining critical path towards becoming a drug discovery project . Research representative in the corporate Idea Fair 2019 2021 collecting ideas across the company on all aspects of improving company business . Biology Area Lead ; Protein Aggregation , Folding Clearance 2022 being responsible for strategic support to Research Project leads and Biology Leads in linking biology to indication . Strong external engagement in work facilitating commercialization of research at universities and increasing collaborations between academia and industry University of Aalborg , DK ; University of Aarhus , DK ; University of Lund , S ; MJ Fox Foundation , US . Technologies :",idps;small molecules;stability
"Scientist II . . I am an independent thinker , tinkerer , and astute observer . My research helps uncover quantitative physical principles of 4D genome folding and its relation to life and disease . I communicate and collaborate effectively with leading scientists in diverse fields spanning from embryology to microbiology . My key expertise includes the development of 3D genomics pipelines , super resolution imaging and data analysis , and modeling of polymer dynamics .. Technologies :",
"Professor of Bioinformatics . . Development of novel computational tools for the prediction of protein structures , functions and interactions from amino acid sequences . See : http : www.reading.ac.uk bioinf Prediction and experimental verification of the effects of mutations on protein folding and function Application of computational methods for understanding the molecular mechanisms of cardiovascular function and disease Development of algorithms for the evaluation of the quality of 3D models of proteins and setting data standards for theoretical model validation High performance computing for the large scale structure and functional annotation of the proteomes of organisms relevant to food security Participation in the biennial experiments for the Critical Assessment of Techniques for Protein Structure Prediction CASP Funding from BBSRC , MRC , Diamond Light Source , RCUK , International Governments . Technologies :",
"Research Scientist . . Ten years experience in expression and purification of membrane proteins for functional and structural studies . Developed target specific strategies for protein expression , affinity purification and reconstitution of proteins into artificial lipid environments . Trained in time resolved optical spectroscopy and fluorescence spectroscopy methods , as well as in standard biochemical and molecular biology approaches , including genetic manipulations in bacteria and yeast . Experienced in experimental design , problem solving , data analysis , and science communication . . Technologies :",membrane proteins;characterization;expression
"Scientist II Gene Therapy , Payload Engineering . . Passionate scientist with strong quantitative background and 6 years of experience in cell biology , genetic engineering , and biotechnology . Rigorous , results oriented , and hypothesis driven problem solver . Dedicated mentor and team player . Strong presentation skills . Fluent in English and German .. Technologies :",
"Research Biochemist . First author PDB depositions : 6GRL , 6HH7 and 6HH8 6HZN . These PDB files will be cited in 2 of my first author upcoming publications .. Published first author article using SAXS and Cryo EM . . I am educated to PhD level combining 9 years of research experience in biochemistry with teaching and research supervision , having long standing interest in drug discovery process . Through my professional experience I have accumulated considerable experience in protein expression purification structural studies through the field of biochemistry , taking responsibility to maintain instrument , do research with own initiative . I consider myself creative for problem solving and enjoy taking responsibilities . As a person I am highly motivated to play a great role in healthcare industry utilizing my aspiration and experience . Keywords : PCR , Primer design , Cloning , Protein Purification , Affinity Chromatography , Size Exclusion Chromatography , Protein Crystallization , Differential Scanning Fluorimetry , Dynamic Light Scattering , Lipidic Cubic Phase Crystallization , Crystal Growth Optimization , Crystal fishing and freezing , Crystal native and anomalous data collection , Crystal data processing , Crystal structure solving , Crystal structure refinement , Small Angle X ray Scattering , . Technologies : Xray;CryoEM;SLS DLS;DSF",proteins;characterization;expression;structure
"Senior Outsurcing Manager . . Fifteen years of R D experience in the pharmaceutical and biotech industry with a sound understanding of the pharmaceutical value chain Sound managerial and leadership experience with interdisciplinary and multicultural teams in local and global settings resulting in numerous successful drug discovery projects as well as technology and outsourcing collaborations Profound expertise in medicinal chemistry of small molecules , peptides , and enabling technologies with a track record of multiple drug candidates which entered into pre clinical and clinical development o Biological target classes : GPCR receptors , transporters , ion channels and enzymes o Therapeutic areas : neurological , psychiatric , and cardio metabolic diseases Enjoy managing and optimising organisational and disciplinary interfaces including science business , research development , chemistry biology , and between entities to enhance value creation Support innovation culture and LEAN thinking . Technologies :",membrane proteins;peptides;small molecules;interaction
Bioinformatics Scientist . . . Technologies :,
"Chief Technician . Supervisor of Life Science Soft Materials area . I received my master 's degree in natural science followed by a PhD in animal biology at the University of Milano Italy where I received my formation in electron microscopy . After a research period at Rutgers University in Camden , New Jersey USA I received in 2011 my second master s degree in molecular biology at the university of Pavia Italy . In 2010 I moved at the Istituto Italiano di Tecnologia IIT in Genoa , where since 2017 I am part of the staff of the Electron Microscopy Facility . During these years I deepened my knowledge on the electron microscope itself focusing my interest on data collection and data analysis with particular emphasis on cryo electron microscopy and cryo processing methods . In these fields I am author of over 80 publications in international scientific journals with a h index of 23 source : Web of Science .. Technologies : CryoEM",structure
". . Structural biologist working in drug discovery , studying the atomic structures of integral membrane proteins using cryo electron microscopy and X ray crystallography . Technologies : Xray;CryoEM",membrane proteins;structure
"Senior Research Scientist , Medicinal Chemistry . . HIGHLIGHTS Contributed to the drug discovery projects from lead identification through lead optimization in Oncology Kinases , Microtubule Targeting Agents , Antifolates , and PROTACs . Medicinal chemist with a strong background in the execution of multi step 15 organic synthesis . Proficient in catalytic , organometallic chemistry , peptide coupling , regioselective , ring formation reactions . Experienced in structure based drug design and ligand based drug design . Expert in chromatographic techniques , NMR , HPLC , and LC MS . Expert in computational programs such as Schrodinger Drug Discovery Suite Maestro , Glide , MacroModel , Prime , etc . , Chemical Computing Group MOE , Spartan , Discovery Studio , Sybyl , PyMOL , ACD Labs , ChemDraw , Chem3D , etc . Expert in ELN , Chromeleon , Advion , Topspin , CMC assist , MestreNova , MestRe C , Scifinder , Endnote , etc . Proficient in the analysis , interpretation , and visualization of the results of small molecule drug discovery projects . I enjoy working as part of a team to solve complex scientific problems that contribute to improving human health . My doctoral research was focused on the design and synthesis of microtubule targeting agents MTAs , Receptor Tyrosine Kinase inhibitors , Antifolates , and PROTACs for cancer .. Technologies : NMR",molecular glues;interaction;screening;stability
"Bioinformatics Consultant . . Multidisciplinary researcher and data analyst with a focus on extracting knowledge from even the noisiest , heterogeneous biological data via inferential statistics , Bayesian statistics and machine learning . Effective communicator and coordinator , verbally and graphically relaying results to collaborators from both technical and non technical backgrounds and guiding complex projects to completion . Experienced software developer , comfortably using Python , R , and C , along with standard Unix tools to develop efficient analysis pipelines . Strong commitment to good software engineering and data management principles .. Technologies :",
"Vice President , Molecular Sciences . . . Technologies : Xray;DSC",
Senior Scientist . . Structural biologist interested in using cryo EM and X ray crystallography to accelerate the drug discovery process . Experienced in deciphering the structure and function relationship of macromolecules that are associated with human dieseases .. Technologies : Xray;CryoEM,proteins;structure
"Senior Bioinformatics Scientist . . Researcher applying machine learning and data visualization techniques to high throughput sequencing data to answer questions across a range of biological fields . Broad interests and a passion for thinking deeply about data to learn domain knowledge . Biological experience includes : metagenomics , immunology , virology , marine biology , infectious diseases , developmental biology , microbiomes , and stem cell biology . Other interests include : quantum information and computational linguistics .. Technologies :",
"Ontology Informatics Consultant . Provision of ontology , information architecture informatics services within the Life Sciences . . Experienced consultant with a demonstrated history of working on software and informatics projects in the life sciences . Skilled in Technical Writing , Technical Project Management , Data Architecture and modelling UML , XML , XSD and JSON schema , Ontologies and other semantic technologies RDF , OWL , SPARQL . Deep experience in metadata management and cataloguing . Research and development professional with a PhD focused in Computational Biology protein structure analysis from University of Leeds . . Technologies :",
"R D Support Scientist . Coordinating and performing product and process improvement efforts and sustaining activities for CMS R D Cascadion assay system . . Experienced research scientist in the field of biochemisty and biotechnology , special knowledge in glycobiology . Versatile experience in hands on laboratory work as well as scientific research planning , project work and documentation . Knowledge in glycan and protein , especially antibody analytics , glycoengineering and protein expression . Specialties : Glycans , antibodies , chromatography and HPLC , mass spectrometry . Technologies :",antibodies;developing;expression
"Postdoctoral Associate . . I am a biochemist seeking to better understand how solute carrier SLC transporters , the second largest membrane protein families and emerging therapeutic targets , mediate metabolic flux and maintain cellular homeostasis . My expertise includes multiple biochemistry and structural biology methodologies . Experienced working with nematode C.elegans and mammalian cell culture .. Technologies :",membrane proteins;structure
"Computer Scientist in Genomics . Currently studying the Huntington HTT gene repeat instability using the 100,000 Genomes Project database . . Interested in everything to do with the brain and genomics . . Technologies :",
Research Fellow . . . Technologies :,
"Staff Scientist . Department of Cellular Logistics . I 'm a biochemist and structural biologist with experience in membrane protein biochemistry , cryo electron microscopy and X ray crystallography . My research focuses on the mechanisms of protein transport across membranes .. Technologies : Xray;CryoEM",membrane proteins;structure
"Senior Scientist . . Having more than a decade of experience in the field of cryo electron microscopy cryo EM and working on various structural biology projects , Kushal has explored the complete EM pipeline : from the benchwork to purification of macromolecules ; to sample preparation for cryo EM ; to collecting high resolution EM data ; to image processing and 3D reconstruction ; and finally to model building and analysis . Serving as an academic researcher for 10 years , he transitioned to industry to venture into new opportunities and possibilities . Currently , as a senior scientist at Vironova AB , he provides GMP compliant EM services to the pharma industry for the analysis of vaccines , gene therapy and drug delivery nanoparticles .. Technologies : CryoEM",carriers;structure
"Team Lead Conjugation . . I spent several years as a PhD student in the lab of Prof. Markus Wahl at the Freie Universit t Berlin working on molecular mechanisms of spliceosome activation and I obtained my doctoral degree in biochemistry in 2018 . My work was published in several renowned peer reviewed journals PNAS , eLife . I have a strong expertise in protein and RNA biochemistry , structural biology and enzyme kinetics . In 2018 , I joined EUROIMMUN as a Research Scientist in antibody development for IVD , with a main interest in antibody conjugation for chemiluminescent immunoassay technology .. Technologies :",antibodies;developing
"Konsulent . . P dagogisk antropolog med stor interesse , viden og erfaring i at unders ge kulturelle forhold og sociale processer i relationer , institutioner , organisationer og virksomheder . Jeg har specialiseret mig i det psykisk sociale arbejdsmilj , med s rligt fokus p ledelses medarbejder forhold , kommunikationsformer og identitetsskabelse . Jeg g r til arbejdsopgaver med en unders gende , analytisk og systematisk tilgang , og arbejder gerne ud fra et bredt spektrum af kvalitative og kvantitative metodiske redskaber . Jeg har spidskompetencer i at arbejde strategisk og s tte spot p nye sammenh nge og m nstre . Jeg drives af at v re med til at skabe v rdifulde praksisser , hvor udvikling , trivsel og l ring underst ttes . I mit arbejde kendetegnes jeg ved at v re udadvendt , dialogskabende , ih rdig , velorganiseret og handlekraftig . Samtidig ser jeg humor og en uformel omgangstone som en vigtig del af et godt arbejdsliv . Derudover har jeg en professionsbachelor som p dagog og har dybdeg ende faglig viden samt praksis erfaring indenfor b de dagtilbud , skole og social special omr det .. Technologies :",
Professor of Theoretical and Computational Biology . . . Technologies :,
"Scientist . . I am a Biotech Engineer with 7 years of experience in biotech and pharmaceutical industry . Currently I work as a Scientist in Process Development team at Kiadis Pharma . I 'm responsible for development and optimization of cell therapy products CMC , executing technology transfer activities , reviewing technical documentations . I have understanding and experience of cell therapy GMP manufacturing . Previously , I worked as a Scientist Assistant in Swiss biotech company , where I was responsible for upstream of mononuclear antibody production . All my gained experience skilled me to be fast learner while meeting rigorous tasks and demanding schedules . Moreover , I am able to work under time pressure as a part of the team and independently . I thrive on challenges and I will spend the time and effort it takes to fulfill it . . Technologies :",biologics;developing;quality
"Research Scientist Cryo EM . . I am a Protein Biochemist with several years of experience in membrane proteins and cryo electron microscopy . I have profound analytical skills and great communication skills in presenting complex science and data . Through working in international teams , I have gained intercultural experiences that shaped the way of my professional and personal life .. Technologies : CryoEM",membrane proteins;structure
"Quantitative Research Analyst . . I develop proprietary , and applying existing , machine learning and statistical techniques for use in a large medium low frequency daily to monthly prediction horizon systematic equities strategy which is traded globally . My main focus has been signal generation , although I have also worked on portfolio optimisation . Prior to working in finance , I was a posdoctoral researcher at the University of Nottingham where I conducted research into machine learning , statistics and computational biology . My work has appeared in top machine learning and applied maths journals including KDD 2015 in Sydney https : scholar.google.com citations user Ave6hfMAAAAJ hl en . I have a PhD in applied maths , awarded in 2010 . I came fourth in the Kaggle brain computer interface machine learning challenge for the classification of multi variate EEG time series signals . I was subsequently interviewed for the Kaggle winner s blog , which you can read online here https : medium.com kaggle blog winners interview bci challenge ner2015 f851dc2599a0 .. Technologies :",
"Cryo EM Research Professional . Cryo EM expert support for single particle structure determination projects in the Biochemistry department . Scientist with a PhD in Biochemistry and Molecular Biophysics from The University of Chicago , with additional skills working with C C and Python programming . Currently focused on the purification of diverse and difficult proteins and determining their structure s by cryo electron microscopy . I am interested particularly in structural biology , using computational tools to improve the accuracy and throughput of biochemistry wet lab techniques , and finding or creating software to effectively to solve biochemical and structural problems . Skills include : optimization of protein purification , chromatography , crystallography , cryo EM , protein DNA machines , FRET and fluorescence anisotropy , and computer hardware software for scientific needs .. Technologies : CryoEM;FP;FRET",proteins;structure
"Director Medicinal Protein Chemistry . . Following his PhD study in the Organic Chemistry department at the Radboud University in Nijmegen , The Netherlands , Patrick co founded and built Syntarga , a biopharmaceutical company developing Antibody Drug Conjugate technology . After Syntarga 's acquisition by Synthon in 2011 , he headed the Antibody Drug Conjugates department within Synthon Biopharmaceuticals , now Byondis . Since 2014 , he is leading the Medicinal Protein Chemistry department , focusing on the early stage development of both antibody drug conjugates and small molecule drugs . At the same time , he is also leading R D projects as a project manager . He has a focus on early stage R D and a strong interest in both platform and product development . . Keywords : Organic Chemistry , Protein Chemistry , Medicinal Chemistry , Project Management , R D Strategy , Pharmaceutical , Biotech Life Sciences Industries . Values : Teamwork , Collaboration , Incitement , Excellence , Growth , Enjoyment . Technologies :",antibodies;small molecules;engineering
"PhD Fellow . Optimization of fragment derived small molecule Keap1 inhibitors by advanced medicinal chemistry strategies macrocycles , prodrugs and PROTACs UBIMOTIF Marie Sk odowska Curie . . Technologies :",molecular glues;small molecules;developing
"Institute Research Investigator Structural Biology . . I am a membrane protein biochemist and have been using cryo EM as a tool to understand the structure function relationship of various membrane proteins by reconstituting them into lipid nanodiscs . Cryo EM is a very powerful technique to visualize protein and protein complexes in their close to native state . I have extensive experience in various biophysical methods and single particle image analysis , 3 D reconstruction of protein and protein complexes using cryo electron microscopy . . Technologies : CryoEM",membrane proteins;structure
Research Associate . New Antibody Product Research Alternative Immune Reactive Cells in Oncology AIRCO team . . Technologies :,antibodies;developing
". . Biochemist focusing on the function and structure of membrane proteins by studying cytochrome c oxidase kinetics with high time resolved spectroscopic methods such as flash photolysis and flow flash . Interested in : Developing better methods for science communication , both to non scientists and colleges . Improving collaborations and networks in and between universities and companies in the Stockholm Uppsala region . Specialties : Communicating science , membrane protein expression and purification , spectroscopy , enzyme kinetics , cytochrome c oxidase , proton pumping across biomembranes , flow flash technique , flash photolysis .. Technologies :",membrane proteins;structure
"Associate Scientific Director Team Leader AI Design Team . I have more than fifteen years of drug design experience supporting projects across all therapeutic areas from early target identification to late lead optimization , as well as rationalising design implications of clinical data . I have a strong track record in the business integration of data analytics , large scale multi task learning AI approaches and cloud environments into a pharmaceutical context and have created , coordinated and delivered various strategic innovation initiatives along such lines with multiple million Euros of budget . This includes , but is not limited to collaborating with many partners , covering academic groups , data analysts , software engineers , medicinal chemists , biologists , and other drug development companies . I have successfully delivered business value to therapeutic area projects using AI and are leading a team of multiple FTE to support our internal drug design project teams as well as driving the strategic AI initiatives . In addition , I am an avid problem solver , am used to working successfully in a fast paced dynamic environment and am a strong believer in diverse teams to reach a business integration and cutting edge innovation . Additional skills : project coordination , team leader , contract negotiations , structure based drug design , fragment based drug design , drug resistance modelling , MBTI : ENTJ . I have more than fifteen years of drug design experience supporting projects across all therapeutic areas from early target identification to late lead optimization , as well as rationalizing design implications of clinical data . I have a strong track record in the business integration of data analytics , large scale multi task learning AI approaches and cloud environments into a pharmaceutical context and have created , coordinated and delivered various strategic innovation initiatives along such lines with multiple million Euros of budget . This includes , but is not limited to collaborating with many partners , covering academic groups , data analysts , software engineers , medicinal chemists , biologists , and other drug development companies . I have successfully delivered business value to therapeutic area projects using AI and are leading a team of multiple FTE to support our internal drug design project teams as well as driving the strategic AI initiatives . In addition , I am an avid problem solver , am used to working successfully in a fast paced dynamic environment and am a strong believer in diverse teams to reach a business integration and cutting edge innovation . Due to a computer science background I am also strategically interested in risk reduction and data analytics . I am an avid problem solver , am used to working successfully in a fast paced dynamic environment and am a strong believer in diverse teams to reach a business integration and cutting edge innovation . Additional skills : project coordination , team leader , contract negotiations , structure based drug design , fragment based drug design , drug resistance modelling , pro activity , information management , computer science expertise , high reading affinity , MBTI : ENTJ . Technologies :",
"Assistant Professor . I am starting up my own group in the Department of Molecular and Cellular Biology . Our research will focus on the structures and functions of electron transport membrane proteins . . I am an Assistant Professor of Molecular and Cellular Biology at UC Davis . Previously I was a Marie Sk odowska Curie fellow at IST Austria in the laboratory of Dr. Leonid Sazanov . I did my PhD at the Rockefeller University in the Laboratory of Molecular Neurobiology and Biophysics with Dr. Roderick MacKinnon . I am interested in continuing research in the biophysics of membrane proteins . With a special interest in structure function studies using single molecule cryoEM . Please check out the video below to watch the public presentation portion of my thesis defense . Introduction by Rod MacKinnon . My full thesis can be found here : http : dspace2.rockefeller.edu jspui handle 10209 554 See below for a list of selected publications or check out my ReseachGate profile for a complete list . Specialties : Membrane protein biochemistry , biophysics and structure .. Technologies :",membrane proteins;characterization;structure
"Bioinformatics manager . . Since I was in high school , science based subjects intrigued me , especially biology . I was also fascinated by computer science . Therefore , I chose to get my BSc in Biology and MSc in Bioinformatics , thus succeed in combining those two fields of study . As a Newly Graduated with a MSc in Bioinformatics , I am looking for opportunities to apply and further develop my bioinformatics skills . In my two years of lab experience I have learned to be a productive team player and developed strong communication skills . Time management and prioritization of tasks was also crucial to meet certain deadlines . While attending the Post Graduate Program and working in the lab I have also developed skills that are more related to IT , including , knowledge of working with operating systems WINDOWS , UNIX , LINUX and Mac OSX , Programming C , Perl , Python and Java , Database Design and Management in MySQL and use of Bioinformatics as well as Biostatistics tools . I am currently seeking a position in bioinformatics . Particularly , I am interested in programming , analysis of biomolecular sequences and biomolecular structures , molecular recognitions and structural drug design .. Technologies :",
"Head of Cryo Electron Microscopy Core Facility . . As Head of the Cryo Electron Microscopy Core Facility at Human Technopole , I am responsible for maintaining a facility capable of state of the art multi flavoured electron microscopy single particle , single cell , electron tomography and CLEM .. Technologies : CryoEM",
"Process Scientist . . Sr . Manufacturing Process Specialist Process Owner . Process Owner of Mosaic , DSP a New Product Introduction NPI , Mosaic is a protein HIV preventive vaccine regimen in phase 3 clinical trials . . Process Owner of RSV f , DSP in transition from NPI to commercial production , RSV f is a protein based on the production of adenoviral vectors to activate the human immune system . . Process Owner of Sylvant USP DSP , a commercially established oncology protein IgG , and is recently in decommissioning . Perform impact assessment to determine potential product equipment license impact because of the quality issue . Investigation lead and define corrections and or CPA s. Participates in comprehensive engineering activities to develop and implement effective , high quality process and design guidelines for dissemination throughout the division . . Provide complex design reviews and feedback for improvements in manufacturability . Implements equipment , materials , and process performance requirements , perform vendor searches and equipment evaluation to ensure the adequate capacity to produce quality products in required quantities at an effective cost . . Facilitate experiments and capability studies , develop process specifications , and design and procure process tools . . Evaluate and advise on the selection of suitable equipment for optimized , balanced line performance . Process analyses of new systems and equipment with the intent of achieving continuous improvement of present methods . . Edit and publish process documentation and training materials for processes , materials , and equipment . Conduct all activities in strict accordance with cGMP regulations and EH S policy . Highly innovative , proactive , and creative Sr . process scientist with a strong sense of ownership . . I feel uncomfortable when people suggest : It can t be done I like challenges and I am resourceful in finding solutions . . In previous work : . I created and implemented a new production process for the purification of antibodies of Mastivax s . replacement of antibiotics . . Co inventor of the patented DSM technology Single use antibody purification . Developed a new cGMP compliant technology EBA , RHOBUST and implemented this for global . DSM sites and its customers . . Technologies :",biologics;carriers;developing
Scientist . . Neslihan Ta is an environmental microbial ecologist and a Research Scientist in the Climate Ecosystems Division at Berkeley Lab . Dr. Ta studies microbial transformation of natural and anthropogenic carbon in terrestrial and aquatic ecosystems . She received her Ph.D. and MSc from Wageningen University in the Netherlands . Dr. Ta s current research projects spans from studying impact of climate change in soil microbial functions in the Arctic to fate of terrestrial carbon in aquatic ecosystems . Dr. Ta s expertise lies on applications of multi omic technologies in order to understand microbial function in the environment .. Technologies :,
"Researcher . . With extensive experience in the field of Bioinformatics , Bacteriology , Molecular Biology , Protein Biochemistry , Structural biology and Drug discovery , I wish to continue my research in these areas . I have a huge interest in understanding host pathogen interactions using various techniques and data analytics , thus hoping to contribute towards discovering mechanisms enabling the development of improved diagnostics and treatment strategies , thus contributing towards developing a better future . I enjoy reading and learning PhotoVideography in my free time . Google Scholar : http : scholar.google.co.in citations user ML7X29AAAAAJ hl en Research Gate : https : www.researchgate.net profile Sanjiv Kumar2 contributions ev prf act Thank you for visiting my profile . Please let me know if you have any questions Email : drsanjivk gmail.com . Feel free to connect .. Technologies : DSC;CD",membrane proteins;interaction
Postdoctoral Researcher . Beckmann group at the Gene center Munich Structural studies of co translational quality control using cryo EM . . Currently researching quality control response to aberrant translation using cryo EM . For an up to date publication list please check : https : www.researchgate.net profile Petr Tesina https : scholar.google.com citations user e eUxZoAAAAJ . Technologies : CryoEM,quality;structure
"Senior Staff Scientist Mass Spectrometry . Clinical proteomics mass spectrometry . Experienced Staff scientist with a demonstrated history of working in the biotechnology industry . Skilled in Membrane Proteins , Liquid Chromatography Mass Spectrometry LC MS , Clinical Proteomics , Protein Purification and targeted Mass Spectrometry . Strong LC MS experimental design professional with a Doctor of Philosophy Ph.D. focused in Biological chemistry from the University of Ioannina .. Technologies :",
"Vice President Enzyme Research . . Industrial biotechnology holds the promise of solving a large amount of the problems associated with a densely populated world and a changing climate . Recent developments in automation , data driven molecular discovery and experimental methods have made it possible to develop new biotech solutions enzymes , drugs , microbes and production strains faster than ever before . The next few decades will likely see a revolution in how widely these solutions are adapted across industries from food production to chemical engineering to provide a greener better world for all of us . I am currently heading up the Enzyme Research area at Novozymes . My daily tasks include developing business and R D strategies as well as ensuring progress in our discovery projects . I have almost a decade of academic experience as Senior Lecturer at University College Dublin . 25 years of research experience in bioinformatics , programming , data analysis , protein analysis and protein engineering design , with protein electrostatics and protein stability as a specialty . 50 peer reviewed papers , 8000 citations , H index of 34 , 8 patents . List of publications including number of citations is available at Google Scholar : http : scholar.google.ca citations user CvQ4t90AAAAJ Specialties : Protein engineering , data driven molecule optimization , protein pKa calculations , Structural bioinformatics , enzyme structure function studies , algorithm development for protein structural energy calculations . Technologies :",enzymes;proteins;characterization;engineering;stability
"Bioinformatics Core Director . . I am setting up a Bioinformatics Core at The University of Sheffield . We will provide high quality Bioinformatics service to assist researchers in the planning , analysis , visualisation and interpretation of their high throughput data . We will also provide training courses on essential data analysis skills and more specialised training in the analysis of NGS related data . http : sbc.shef.ac.uk . Technologies :",
"ProRector for Research ProRettore alla Ricerca of the University of Pavia . . My principal research interest is the elucidation of the intricate mechanisms of protein protein interaction and signaling . The various processes that fall under the description of molecular recognition ranging from transient inter molecular interactions , conformational changes , proteolysis mediated activation and inhibition , to many others represent for me one of the most fascinating aspects of nature elegance and complexity . I merge structural biology with biochemistry and biophysics to characterize large macromolecular complexes and elucidate their structure function relationship to put the molecular insights in the proper biological context . I am co author of 40 publications in international peer reviewed scientific journals of high profile including Science , PNAS , J. Neurosci , Cell Reports and JACS 15 papers as first author and 3 book chapters 2 of them as first author . I am a board member of AIRIcerca , the association of Italian researchers aiming at increasing the networking opportunities among researchers and promoting scientific knowledge among the Italian population , and I am currently serving as Editor in Chief of the association 's science popularization journal AIRInforma .. Technologies : Xray;CryoEM;NMR",proteins;characterization;interaction;structure
Principal Scientist . . . Technologies :,
"Staff Scientist , Bioinformatics Software Engineer . Led the design and development of the annotations pipeline of Ion Reporter IR , a leading bioinformatics analysis software suite , built upon the cloud on Amazon AWS and local servers . Designed and developed an automated end to end software workflow which consists of millions of records from multiple public and private genomic annotation databases that helps customers annotate their genomic variants to efficiently analyze and identify driver mutations in clinical research . Designed and implemented a novel algorithm PATENT US 20130091126 A1 to resolve ambiguous indels when annotating variants using Genome Analysis Toolkit GATK . Team lead of a remote software engineering team at Bangalore , India for the past 5 years . Planned software deliverables , distributed and discussed ongoing work with the team , guided and performed code reviews . Designed and implemented a new software pipeline in Python to analyze Alpha Beta diversity using QIIME Quantitative Insights Into Microbial Ecology for Metagenomics16S NGS based workflows . Designed and developed novel application features in Java , Python and mongoDB using GIT for source code version control , maven for dependency control and Eclipse IDE and participated in scrums and sprint planning following agile production software development life cycle SDLC . Involved in development of a software analysis pipeline to detect CNVs Copy Number Variants from Ion Torrent sequencing reads using a machine learning approach utilizing Hidden Markov Models . Designed and developed a distributed Java workflow , inspired by the Map Reduce pattern for the CNV pipeline . Led the efforts to successfully support GRCh38 Human Reference genome with alternate loci in IR software with minimal architecture design changes both in the code and representation of the data in the database tables . Contributed to the development of HGVS notations of variants into IR . . Software Engineer with experience in software development , machine learning , data analysis and bioinformatics . 8 years of programming experience in agile production software development life cycle in industry . 3 years of postdoctoral experience performing extensive in depth statistical data analysis of large scale gene expression , DNA methylation , genotyping , microarray and NGS Next Generation Sequencing data sets . Excellent communication and management skills with 5 years of experience as a software team lead . Skills Programming languages : Java , Python , C C , R Bioconductor , Shell script . Bioinformatics tools : UCSC Genome Browser , Genepattern , Cluster JavaTree , Circos , CLC Genomics workbench , Expander , GeneSpring , Cytoscape , GSEA , NIA Array Analysis tool , SAMtools , GATK Databases and infrastructure : mySQL , MongoDB , Hadoop Web applications : JavaScript , HTML Operating systems and tools : Git , Maven , SVN , Eclipse , JIRA , Stash , Windows , UNIX , Linux , MAC OS , CPLEX , ClearCase , Dreamweaver , Vim . Specialties : Software design and development , programming , machine learning , data analysis , statistics , bioinformatics , next generation sequencing , microarrays , algorithms , DNA methylation , epigenetics . Technologies :",
Science Lead . . . Technologies :,
"Associate Director , Bioinformatics Computational Biology . . A diversly trained computational scientist that is driven by the goal to improve human health by creating and using new computational technologies with high throughput molecular data . I have 10 years of experience working in ' omics ' era data science in both academic and industry settings . Currently , I work as a bioinformatics computational biologist , contributing to the drug discovery process with advanced analytics of internal and external datasets , identifying or developing new analytical methods , and collaborating with lab scientists to advance drug discovery programs . My previous roles as a bioinformatics research scientist have entailed a wide range of NGS data analysis and methods development projects .. Technologies :",
"Associate Director , Bioinformatics . . . Technologies :",
"Automation Scientist . Oxford Nanopore Technologies is a multidisciplinary company employing nanopore science , molecular biology , electronics , informatics and more to deliver sequencing platforms in fully scalable formats from pocket to population size genetic sequencers . As an automation scientist I work on development , optimisation and validation of automation solutions for ONT sequencing kits . . Driven and committed biotechnologist with research and industry experience . I 've worked in microbiology , molecular biology , computational biology and clinical diagnostic laboratories . My special interests are in genetics , metabolism , systems biology , and microbiology .. Technologies :",
Higgins Professor of Natural Sciences . . . Technologies :,
"Scientist II . Protein Biochemist Structural Biology Group . I am a protein biochemist with over ten years of combined doctoral , postdoctoral , and industry research experience in the life sciences . I have extensive knowledge of protein biochemistry and molecular biology methodologies with specific expertise in the following : Protein expression and purification bacterial and mammalian cell culture Antibody engineering Protein characterization , including biophysical and binding assay analysis SEC MALS , DLS , DSF , BLI Mammalian cell culture and cell based assay development Lentivirus production and viral neutralization assays pseudotyped SARS2 , Ebola , and HIV Design and implementation of in vivo studies for immunological vaccine characterization Construct design , mutagenesis , and molecular cloning Single molecule fluorescence microscopy . Technologies : SLS DLS;BLI;DSF",antibodies;proteins;characterization;engineering;interaction;structure
"Senior Lecturer in Computational Biology Machine Learning . . Kevin Bryson is an Senior Lecturer in Computational Biology Machine Learning in the University of Glasgow School of Computing Science . His lab focuses on applying computational , mathematical and statistical approaches to understand clinically relevant biological systems with the aim to integrate diverse data sources and techniques to develop models that can diagnose and stratify diseases . He is the Director of the MSc IT and SD degree programmes . He teaches machine learning deep learning , Java programming and databases .. Technologies :",
"Manufacturing Science Technology Scientist . Improved and developed bacterial and viral vaccines for global health and immunization programs run by WHO GPEI , PAHO and UNICEF for polio , tetanus , diphtheria , besides bacterial products for immunotherapy of cancer . Provided troubleshooting solutions related to deviations and formulation challenges . Designed experimental plans with a close look on practical work based on scientific guidelines aiming at addressing shortage on supply of vaccines worldwide . I specialize in formulation , drug product development , manufacturing and physicochemical preclinical characterization of vaccines , novel drug delivery systems for targeted and controlled release of active small and large molecules via oral , intravenous and intramuscular administration routes . I have experience with scale up and technology transfers . Additionally , I perform PK BE data analysis , modelling and simulations . Specialties : . Formulation of viral vaccines and bacterial products for cancer . In vitro in vivo correlation IVIVC and pharmacokinetic PK predictions . Pre and clinical data analysis , statistics , modelling and simulation . Design of experiments DOE , Quality by Design QbD . Technology transfer from pilot to pivotal phases and CMOs . Analytical method development e. g. U HPLC , M DSC , TGA , PXRD , rheology , DLS , and others . Formulation of microparticles based on natural and synthetic polymers . Design of lipid based formulations for oral delivery of poorly soluble drugs . Development of liposomes for targeting of atherosclerotic plaques for therapy and imaging . Physicochemical , toxicological and kinetics characterization of novel drug carriers . Writing of scientific material in English , French and Portuguese . Teaching on Pharmacology , Pharmacy Practice , Quality Control , Medicinal Chemistry , Cosmetics and English . Technologies : SLS DLS",biologics;carriers;characterization;developing;formulation
"Senior computational biologist . . A computational biologist with extensive wet lab experiences . A goal oriented problem solver by developing custom made computational pipelines . Interested in using integrative omics analysis to identify therapeutic targets and biomarkers , then designing and doing experiments to validate .. Technologies :",
"Scientist , Computational Chemist . Computer Aided Drug Design Structure Based Drug Design Ligand Based Drug Design Docking Protein Ligand Interactions Pharmacophore Modeling Virtual library screening Machine Learning drug discovery . Six years of Pharmaceutical Industry research expertise , an EU Marie Curie Individual Fellow in Computational Drug Design and Computational Chemistry , and Ph.D. Candidate with two years postdoc experience . Experience and competence in protein protein docking , structure ligand based drug design techniques , Chemo informatics with a strong background in modern computational chemistry . Committed team player , flexible and reliable with excellent communication .. Technologies :",
"Scientist . . My work at MSD for 19 years started as a senior Operator in the manufacturing department . I performed down stream purification processes in a cleanroom environmetal under strict GMP conditions . . After more than 3 years of work in the manufacuring facility , I worked as a lab technician . In this function methodology and troubleshooting were the main goals . In this position I expanded my knowledge about chromatographic techniques by performing troubleshooting activities and process characterization studies including the analytical analyses sush as HPLC analysis using Chemstation , ELISA , SDS PAGE , and 2D electrophoresis . . During the years I developed myself to an associate scientist level and have been employed within the PDC Process Analytics department . Main activities of the PA department is providing intermediate process support to the USP and DSP project teams using different analytical methods to determine charged variants , aggregates as well as process related impurities . Good scientific knowledge with regards to HPLC , Empower and ELISA methods was obtained , as well as in depth process knowledge to facilitate the analysis of process intermediates , obtained from monoclonal antibody process development studies . During this function I have various contacts within the local and global network , in order to provide appropriate analytical support and scheduling of the samples requests . Furthermore I have been . responsible for the automation of analytical methods using the Tecan Freedom EVO high throughput and the Waters Patrol automated analysis system on line sample analysis , to contribute to continuous processing . I am a flexible person with extensive knowledge of downstream processing as well as analytical methods . . Technologies :",
Bioinformatician . Clustering of cancer transcripts . . Technologies :,
"Scientist IV , Biotherapeutics . Mass Spectrometry Lab , Biotherapeutics Department Mass spec analysis of intact mass , deglycosylated , reduced , limited digestion and peptide mapping of antibodies , antigens and fusion proteins . Proficient in characterization studies of biologics at forced degradation conditions and gaining expertise in structural analysis of antigen antibodies epitope and paratope mapping by HDX MS . . Motivated , energetic and driven professional with 20 years experience in Pharma . Current role focusing on protein and antibody characterization by HRMS , proficient in intact analysis , peptide mapping , forced degradation studies liabilities identification . Gained significant experience in using HDX analysis for epitope and paratope mapping .. Past roles focused on in vivo PK and bioanalysis . Provides bioanalytical support for various stages research projects by LC MS MS for small molecules and biomarkers . Highly knowledgeable and experienced with bioanalytical method development and validations , extensive experience with small molecules and biomarkers . LIMS systems : IDBS e Workbook BioBook , Watson , GeneData Biologic Proficient in PMi and HDExaminer . Biologics team representative for several early stage discovery projects . Passionate about applying technology to practical applications in a high energy environment . Expertise in organizing executing programs , both science and non science related . Strong oral and written communication skills . Good interpersonal and team work skills .. Technologies :",biologics;characterization;stability
"Scientific Group Leader , Target Structural Enablement . . I specialize in protein purification and structure determination by cryo electron microscopy cryo EM .. Technologies : CryoEM",proteins;structure
"Protein Scientist I . . PROFESSIONAL SUMMARY Highly motivated , detail oriented research scientist with 15 years of research experience in protein purification and characterization , molecular biology , virology , immunology , mammalian cell culture , and experimental mouse models Actively involved in expression , purification involving AKTA systems and biochemical characterization of various recombinant proteins including protein domains and enzymes from bacterial or insect cells in a highly collaborative environment within tight deadlines Developed new methods and improved existing purification methods to generate higher and better yields of challenging proteins Eminent virologist with years of BSL 2 2 experience in viral manipulation , infection , growth , and isolation as well as performing viral titer assays and quantification of virus expression by qPCR Years of expertise in cell line development from vector construction , lentivirus production and transduction , cell culture maintenance and clone screening to cell line characterization Experienced in molecular biology tools including DNA RNA isolation , Northern Southern blotting , PCR , qPCR , DNA sequencing and analysis of sequence data , site directed mutagenesis and CRISPR Cas9 mediated genome editing Extensive experience in cell signaling and mechanism of action studies using various biochemical and immunological techniques like Western blot , immunoprecipitation , ELISA , flow cytometry including FACS and immunofluorescence using confocal microscopy Excellent organizational skills and the ability to prioritize and execute work on multiple , complex projects in diverse areas simultaneously Great ability to build collaborative work relationships required for timely completion of research projects Outstanding written , oral and interpersonal communication skills Consistently earned praise for the ability to lead , motivate and develop associates as well as generate high level of energy and enthusiasm among staff members . Technologies :",proteins;characterization;expression
"Independent Life Science Consultant . perform project management . ensure strategic re focusing of programs e. g. for start ups or spin outs . identify the best opportunities for their technology know how as well as in or out licensing opportunities . develop focused and result driven scientific programs . identify the right partners to make outsourcing work . help create and or grow the team . create a corporate culture introducing a strong result oriented vision focused on the final product . perform due diligence and business intelligence for investors and or Companies . Peter Tomme graduated in 1985 as a Bachelor in Chemistry from the University Ghent , Belgium , where he also earned his PhD in Biochemistry in 1991 . Today , he is an independent Pharma Biotech Management Consultant . In 2006 , he joined TiGenix as R D Director where he was responsible for product and pipeline portfolio development until the end of 2010 . He was part of the team that successfully developed ChondroCelect , the first Advanced Therapy Medicinal Product approved by EMA . In 1999 he was co founder and R D Director of Galapagos where he established the technology platform and target discovery in a large number of therapeutic areas . Peter also served on the Management Teams of both Companies and was part of the teams that successfully concluded the IPO of Galapagos and TiGenix , respectively . Prior to joining Galapagos , he was a Director at Tibotec and part of the drug discovery team for HIV and HCV . He started his professional career in 1994 at the University of British Columbia , Vancouver , Canada as a Research Staff Member specialized in Protein Engineering and the development of pharmaceutical and industrial proteins . Peter is also co founder of CBD Technologies and was involved in the establishment of Arcarios , a young drug development company for bone and joint diseases . Specialties : Biotech R D , therapeutic product development biologicals , cell therapies , general drug discovery , translational medicine development , protein engineering , genomics , stem cell research development , CMC and process improvements , general and operational management . Technologies :",
"Analytical Scientist . Bioneer : FARMA is a business unit of Bioneer located at the Department of Pharmacy , University of Copenhagen with many years experience in all aspects of drug development and characterization . We provide analysis , pre formulation , formulation , as well as in vitro and in vivo evaluation , of both biological and small moleculare drugs . We specialize in oral drug delivery and have developed a range of in vitro models simulating the behavior of drugs and drug products in the gastro intestinal tract . We use cell culture models to assess drug permeability and absorption mechanism . . Cand.scient in nanoscience , PhD in biophysical chemistry . Formulations drug delivery Lipids surfactants excipients Proteins peptides Biomolecule interactions HPLC , FPLC , LC MS Scattering techniques : NR , SANS , SAXS . Technologies :",biologics;carriers;peptides;proteins;characterization;formulation
"Principal Bioinformatics Scientist . . I am interested in solving computationally challenging data science problems from biology and medicine using machine learning , statistics and algorithms .. Technologies :",
"Postdoctoral Research Fellow . Small molecules targeting RNA triple helix and structural elucidation using CryoEM . During my undergraduation , I enjoyed learning chemistry in close relation with biology and was placed among top 15 students out of several hundred . During Master s at Department of Chemistry , Central college campus , Bangalore University , Bangalore , I got strong theoretical and practical training in different aspects of chemistry , which include broad area of inorganic , organic , physical and analytical chemistry in the first year . I specialized in organic chemistry during the second year . In 2011 , I cleared Council of Scientific and Industrial Research Junior Research Fellowship CSIR JRF , securing all India ranking 69 in chemical science . Later , as junior and senior research fellow at Department of Chemistry , Indian Institute of Technology , Kanpur IIT Kanpur , I worked on rational design and development of novel metalorganic framework and lattice inclusion compounds and attended an international summer school on Topological Methods for Expert Systems in Materials Science at Samara State University , Samara , Russia . In 2016 , I joined Nanyang Technological University , Singapore to pursue my doctoral degree under the supervision of Asst . Prof. Chen Gang . My graduate research interest was focused on i the rational design and synthesis of duplex binding Peptide Nucleic Acid dbPNA monomers displaying sequence and structure specific binding to RNA duplex through the Hoogsteen hydrogen bonding and ii fluorescent PNA monomers , which can be used as a diagnosing tool to understand the nucleic acid microenvironment and structural polymorphism that prevail in the nature . As a postdoctoral research associate at Department of Chemistry Biochemistry , University of Notre Dame , I am currently working on small molecules binding to and regulating the activity of the MALAT1 triple helix and other biologically important RNA triple helices . My research interest also focused on elucidating the three dimensional structure of the MALAT1 triple helix in complex with small molecules and proteins using Cryo electron microscopy techniques . Overall , the 10 years of my research journey helped me to develop many skills in different fields of science from synthesis , characterization , to applications with an opportunity to mentor more than twenty students for their masters under graduate dissertations .. Technologies : CryoEM",nucleic acids;small molecules;interaction;structure
"Sr Manager Analytical Development Molecular Bio Assays . Vaccines Process Analytical Development VPAD Janssen Vaccines Leading a Team of 10 dedicated Scientists , Associate Scientists Lab Technicians Development of Molecular Bio Assays and Microbiological Methods for Release , Stability , Characterization and Process Development Qualification , Validation , Verification of Analytical Assays according to Regulatory Guidelines Coordination and leading of Assay Transfer from Development to GMP Quality Control QC Scientific support of Quality Control QC labs Quality Deviation Management Health Authority Inspections Product Characterization Comparability AD QC Technical Integrator for Cell Gene Therapy Products . Talent wins games , but teamwork and intelligence win championships . Michael Jordan . Technologies : CryoEM",biologics;characterization;stability
Scientist . . . Technologies :,
"Scientist . . Ph.D. study and postdoctoral experience in single particle cryo EM research , image processing and 3D reconstruction Extensively trained in membrane protein biochemistry , molecular cloning , yeast genetics and nuclear magnetic resonance NMR spectrometry . Technologies : CryoEM;NMR",membrane proteins;structure
"Biomathematician Biostatistician . . A statistician and computer scientist with many years of working experience in developing and applying statistical methods and bioinformatics tools in the fields of structure bioinformatics , statistical genomics , cancer genomics and gene therapy .. Technologies :",
Senior Research Associate I . . M.Sc . in Molecular Biotechnology . Natural Sciences enthusiast . Working on protein degradation .. Technologies :,molecular glues;interaction
"Research Investigator . . My primary field of interest is protein biochemistry and structural biology . During the course of my career , I have extensively studied structure function relationship of both soluble and membrane proteins in bacterial and mammalian cells . By working in these core specializations , I have amassed invaluable experience in molecular cloning , protein engineering , protein purification , assay development , cell culturing bacteria , insect , and mammalian cells , X ray crystallography and cryo electron microscopy . In addition , I m well versed in thorough functional analysis of proteins using a multitude of biochemical , biophysical , and immunochemical tools .. Technologies : Xray;CryoEM",membrane proteins;proteins;engineering;structure
"PhD Researcher . . PhD Student at University of Bristol from September 2019 Keen to build tools for biomolecular design and functionalisation of proteins . wet and dry experimentalist , interdisciplinary enthusiast . Technologies :",
"Senior Machine Learning Deep Learning Scientist . . Recovering academic and freelance scientist . Interested in genomics , bioinformatics , and machine learning .. Technologies :",
Postdoctoral Research Associate . . Experience in cryogenic electron microscopy cryo EM Familiar with molecular simulation and modeling Having basic programming skills . Technologies : CryoEM,proteins;structure
"Senior Scientist . Protein Purification and Chemistry . Protein Drug Development Protein Chemistry Protein Stability , Protein Analysis , Protein Purification , Chromatography , Filtration , Protein Formulation , Tech Transfer Lab to Pilot , Project Management . Technologies :",proteins;characterization;expression;formulation;structure
"Senior Director , Discovery Bioinformatics . . I develop methods to use health information to guide therapeutic strategy . The goal is to personalize treatments , rather than treating cohorts of patients with a standard care and hoping some percentage of them respond . This includes utilizing cloud based storage to house big data , state of the art machine learning algorithms , and massively parallel computing , to build accurate and robust predictors , as well as web technologies to power intuitive exploration and reuse of those predictors .. Technologies :",
"Director , Digital Transformation Sciences . . . Technologies :",
"Senior Scientist . Bioneer A S is a small CRO and we also deliver recombinant proteins for our customers . I 'm responsible for the protein purification , protein characterization and product development in the protein chemistry area . For protein production we use different prokaryotic expression systems as well as mammalian cell systems CHO and HEK293 cells . Some of my larger projects the recent year has been with in protein purification process development , technology development and protein pre formulation studies . For protein analytics we mostly used SEC HPLC , RP HPLC , SDS PAGE , capillary electrophoresis CE SDS and cIEF on a Sciex PA800plus . Bioneer A S also deliver services in : Human disease models Molecular histology and detection Drug formulation and characterization . Specialties : Protein purification process development . Protein chemistry and enzymology . Enzyme kinetics and assay development . Protein design and rational protein engineering . Recombinant protein expression in E.coli , Pichia pastoris and Aspergillus oryzae . Glycoside hydrolases . Protein formulation and Protein stabilization . Solubilization of inclusion bodies and protein refolding . Protein crystallography . Studying metal ions in proteins bioinorganic chemistry . Protein structure function analysis . . Technologies : Xray",proteins;characterization;expression;formulation
Head of Bioinformatics . . . Technologies :,
"Research Engineer . Taking care of the NanoImaging Core Facility at Institut Pasteur for Cryo EM applications Sample Freezing , SPA , Cryo ET , lamellae Milling , and provide Cryo EM Training Course . Work on Glacios Cryo TEM , Titan Krios G3i Cryo TEM , and Aquilos Cryo FIB Systems . . Technologies : CryoEM",
Bioinformatics Scientist . . Bioinformatics Computational molecular biology Data analysis Algorithm development Machine learning Statistics C Java Bash R python . Technologies :,
Facility Manager . . . Technologies : CryoEM,
"Research Associate in Bioinformatics PostDoc . . I have more than 10 years experience in data analysis and developing efficient computational models algorithms for different computational problems . My general interest include Numerical Analysis , Data Modelling , Data Management , Data Statistics Analysis , Algorithms Design , Analysis Optimisation , Complex Network and Computational Systems Biology . I have 2 degrees M.Eng . and M.Sc . in Computer Science and obtained my PhD in Mathematics . I can help you with : Algorithm Development Algorithm Analysis Optimization Mathematical Statistical Models Numerical Analysis Data Analysis especially large scale complex datasets modeling and analysis Statistical Methods Tools e.g. , Nonparametric Statistics , Bayesian Statistics , Probabilistic Graphical Models , Hypothesis Test Design , etc . Machine Learning , Data Mining Pattern Recognition Programming and Software Developing High proficiency in mainstream programming languages , such as C C , Matlab , R , Java , SQL , Python Bioinformatics Systems Biology Teaching Tutoring Scientific Presentation Interdisciplinary Collaboration I am an experienced programmer primarily Matlab and R , and also familiar with other programming languages such as C C , Java , Python , Visual Basic , SQL and etc . . I am also experienced in large scale data analysis and data management . I am familiar with different operating systems e.g. , Unix Linux , Windows , Mac OS , statistical models tools and the bioinformatics resources tools e.g. , David , ENCODE , Ensemble , GSEA , Cytoscape , The relevant Matlab toolboxes and R packages . In addition , I have a lot of teaching experience e.g. , giving lectures , delivering tutorials labs , marking , supervising , etc . . In summary , I have demonstrated skills in writing , programming , publication and presentation . From the training courses during my studies and my employment history , I also gained a lot of communication , collaboration , teamwork , management and leadership skills .. Technologies :",
"Sr . Informatics Engineer . All things AWS . . Extensive experience in statistical analysis and data visualization . Solid understanding of software development life cycle processes including requirements gathering , analysis and design , development tools and technologies , release and version control .. Technologies :",
"Scientist . . Highly focused and results driven medicinal organic chemist with experience working as part of a team in academic and industrial laboratories . Currently working in drug discovery developing novel ligands that bind to E3 ligases for eventual application in PROTAC design . Applying both structure and ligand based drug design strategies to progress HTS and virtual screen hits to the clinic . Completed PhD investigating autocatalytic reactions , their mechanisms and applications . Generated project ideas which led to successful experimental results culminating in 3 first author papers . Presented scientific research through posters and oral presentations at international conferences , strengthening my communication abilities . Leadership skills from supervising undergraduate and graduate students .. Technologies :",molecular glues;small molecules;developing;structure
"Machine Learning Research Intern . Startup backed by investors including a16z , GV , Obvious Ventures and Lux Capital , out of Harvard s Church Lab , working on building ML models towards sequence prediction and design of adeno associated viruses AAV for gene therapies . Exploring SOTA DL approaches in protein representation learning transformers , bayesian optimization on novel sequence structural representations MSAs , cryo EM for capsid engineering . . Hey , I 'm Seyone , an 18 year old working at the intersection of machine learning and biochemistry . This summer , I 'll be working at Dyno Therapeutics , an a16z backed biotech startup out of Harvard 's Church Lab , at the intersection of ML guided protein design in NYC . Alongside my work there , I 'm on the open source developer team for DeepChem , a project aiming to build scientific drug discovery tools using machine learning , based out of Stanford University Last summer , I interned on the R D team at Nurix Therapeutics , a public biotech company in San Francisco aiming to discover immuno oncology drugs that harness the body s natural process to control protein levels . Previously , I work on researching cutting edge applications for drug discovery using machine learning , as a research intern in the Matter Lab at the University of Toronto . I was supervised by Prof. Alan Aspuru Guzik . My work is supported by the Emergent Ventures Fellowship from Dr. Tyler Cowen and the Thiel Foundation , alongside the Masason Foundation . In the past , I 've worked at Integrate.ai , building out SaaS AI products for Fortune 500 companies . When I 'm not working on research or programming , I like to go biking , hiking and cook . Please feel free to contact me at seyonec gmail dot com , and check out my website at https : www.linkedin.com redir phishing page url https 3A 2F 2Fseyonechithrananda 2ecom 2Fabout . Technologies : CryoEM",
"Graduate Student Ward Lab . I investigate the structure function of membrane proteins . . I am a graduate student at The Scripps Research Institute , with an emphasis in Structural Biology . I use Cryo EM and Mass Spec to investigate the structure function of membrane proteins of clinical significance . By combining structural and chemical biology , I aim to develop novel therapeutics for rare diseases . Before graduate school , I taught high school math and science . Through this experience , I developed strong interpersonal and management skills that I continue to implement in the laboratory . I also have extensive experience as a student leader . As an undergraduate , I represented over 20,000 students as an elected member of the academic senate and as a lobbyist in Sacramento . I 'm always eager to learn from others with experience in science , education , and related fields . I am also deeply interested in police monitoring , non profit management , and the biotech industry . I can be reached through my profile and at leonandre22 gmail.com .. Technologies : CryoEM",membrane proteins;structure
"Director Of Bioinformatics . . Experienced genomics and bioinformatics scientist with a demonstrated history of working in the research industry . Extensive experience applying next generation sequencing to multidisciplinary fields such as oncology , large scale population genomics , evolutionary and developmental biology . Experience in both wet lab techniques and computational methods . Proven leadership experience in building a 10 people bioinformatics team for building software tools for high quality analysis of NGS data . I have led several high impact projects that have resulted in publications in top tier journals .. Technologies :",
"Principal Scientist II . Oncoimmunology ML Deep learning . I am leading the bioinformatics algorithm development team at Roche Pleasanton , CA . . Technologies :",
"Research Data Analyst . Developed RNA ranker , a tool for ranking therapies based on RNA overexpression , using R Shiny for Treehouse Childhood Cancer Initiative . Create tumor board presentations from pediatric RNA Seq data for clinical partners at Stanford , UCSF , British Columbia Cancer Agency , and Nationwide Children s Hospital . Oversee undergraduate researchers in reviewing publications and variant databases COSMIC , cBioPortal , CIViCdb to generate an internal database of variant pathogenicity . . I am a data scientist with a background in mental health and therapy . I combine my analytical background as an Applied Behavioral Analyst with my passion for computer programming . My interest in Artificial Intelligence development gave me the impetus to begin Udacity 's Machine Learning Engineer Nanodegree program . By learning how to code in Python and use machine learning tools like Scikit learn , pandas , and TensorFlow I hope to develop tools that will increase human productivity and well being . . Technologies :",
"Senior Principal Scientist . . My research interests encompass pharmacology , biochemistry , enzymology , chemical and structural biology . In particular , enzyme kinetic and chemical mechanisms , the study of small molecule target engagement , mechanism of action , binding kinetics , biophysical biochemical characterization , and residence time , in the hits to leads and leads optimization stages . I have significant experience in kinase and enzyme drug discovery , as well as targeted protein degradation . I enjoy applying multidisciplinary approaches to solve challenging drug discovery issues . Specialties : Biochemical and Cellular Assay development , Molecular and Cellular Pharmacology , Protein biochemistry , Enzymology , Biophysics , Targeted Protein Degradation . Technologies :",enzymes;molecular glues;proteins;small molecules;characterization;interaction;screening
"Bioinformatician . . A scientist with academic research experience of over 7 years . I specialize in the genomics and epigenomics of cancer development . My primary research interests are in Myeloid and Lymphoid malignancies . I also develop and contribute to open source computational tools for genomic data analysis . Research interests : Bioinformatics , Leukemia , Personalized medicine , PROTACs . Technical skills : R , Rust , Python .. Technologies :",molecular glues;developing
"PhD Candidate . Working under Dr. Wen Jiang , studying tau , alpha synuclein , and prion filament structures associated with neurodegenerative diseases including Alzheimer s and Parkinson s using cryo electron microscopy cryoEM and cryo electron tomography cryoET . Hockmeyer Hall of Structural Biology Department of Biological Sciences . Graduate student in the field of biophysics and structural biology . Research focus is utilizing cryo electron microscopy to study neurodegenerative filaments . Technologies : CryoEM",idps;structure
Postdoctoral Researcher . . I 'm a Basel based researcher with an interdisciplinary background in biotechnology and microfluidics . I 'm currently working on a droplet based screening system to identify antibodies against new variants of the corona virus . . During my PhD and my PostDoc I have been leading intradepartmental projects and collaborations with companies such as IBM and MEMO Therapeutics . . Technologies :,antibodies;screening
"Research Development Team Lead . Research and development of efficient and high quality deep learning methods for image processing . . Experienced Senior Research Associate with a demonstrated history of working in the higher education industry . Skilled in Mathematical Modeling , Bioinformatics , Computer Science , Statistical Modeling , and Pattern Recognition . Strong research professional with a Doctor of Philosophy PhD focused in Computer Science from Imperial College London . . Technologies :",
"Senior Bioinformatics Cloud Engineer . Second Genome leverages its proprietary drug discovery platform to identify effective peptides , proteins , and small molecule therapeutics that can address unmet medical needs . I architected a new AWS ETL automated pipeline including smart orchestration to ingest public and proprietary data to generate genomic , peptide , RNA seq , or clinical derived features . Patent pending . Collaborated with wet lab scientists and product managers to architect new AWS bioinformatics workflows and communicated frequently about the project progress , prioritization , and roadblocks . Built , optimized , and maintained microservices to automate the execution of common microbiome informatics tasks : Nucleotide Sequence QC : adapter trimming , rRNA , host , and low quality reads removal . Taxonomy identification : sourmash and metacache Functional genes identification : diamond , using kegg and biocyc DB as a reference Genomic assemblies spades and megahit Build CI CD with pytest , AWS codebuild , and infrastructure as code to foster agile software development . Build protein insecticidal toxicity models using public data and features inferred from protein sequence , using MemeFimo , HMMER , USearch , PlasFlow , and iFeature features . Used SHAP values and intrinsic feature importance to infer the biological reason for high scoring proteins Benchmark of our internal Scikit learn , Jupyter ML workflows vs BioDiscML for proprietary Colorectal Cancer CRC datasets . . Courageous computational biologist , software engineer and data scientist , looking constantely to expand technical and scientific knowledege and answer complex biological questions . With degrees in computer engineering and computational biology . Have studied the integration of computation and biology in different questions , doctoral studies focused on human and environmental microbiomes ranging from human skin to marine mammals , air , water , soil , and agriculture . Seeking to apply bioinformatics , computational biology and machine learning methods to model complex microbiological systems , including microbial communities networks and microbe environment interconnections . Applying analytical skills to topics highly relevant to society with great economic impact , most notably agriculture and human health .. Technologies :",
"Doctoral Candidate , pharmaceutical and medicinal chemistry . drug design and synthesis peptide chemistry LC MS and NMR analytic antiviral drugs and proteolysis targeting chimera PROTAC technology Dozent f r Arzneimittelanalytik . Doctoral Candidate at Rheinische Friedrich Wilhelms Universit t Bonn Registered pharmacist M.Sc . in drug design at Goethe Universit t Frankfurt am Main State examination in pharmacy at Goethe Universit t Frankfurt am Main . Technologies : NMR",molecular glues;peptides;developing
Scientific Researcher . Researcher working with electron cryo microscopy Cryo EM at Stockholm University studying the evolution of the mitochondrial ribosome . . . Technologies : CryoEM,structure
"Assistant Professor . 1 Design , conduct , interpret and report on Single cell and bulk transcriptomic , single cell epigenome , and proteomic studies that lead to discovery of biomarkers and therapeutic targets . High throughput Single cell and bulk transcriptomic , single cell epigenome , and proteomic data management and analysis with R , python , and SQL . 2 Supervise Technicians to conduct lung immune inflammation and fibrosis research with both in vitro and in vivo models , such as bleomycin and LPS induced lung injury models , genetic conditional knockout and lineage tracing mouse models , 2D and 3D AT2 cell culture , FACS based cell subpopulation separation , Single cell RNA seq and ATAC seq , mRNA mediated vesicular therapeutic approach . 3 Manage multiple research projects , responsible for independent experiment design , execution , and reporting , such as the determination of the role of growth hormone receptor in AT2 cell niche , regeneration , and differentiation , mechanism of CCXCL14 and Tbx4 in regulating pulmonary fibrosis . 4 Apply new NIH grant , support NIH funded projects . 5 Present data both within institution and external conferences . 6 Collaborate with other scientists to conduct research within institution and external organizations . . Coming from a medical background , with 15 years experience in Research and Development life science Computational biology studies and 10 years experience in gene expression analysis . Ph . D expert in lung immune and degenerative diseases . Specialized in both in vivo and in vitro disease modeling systems lung injury and repair , aging related cellular and molecular mechanisms of fibrosis , stem progenitor cells , mesenchymal immune cell interaction , cellular subpopulations and transcriptional regulations , extracellular vesicles and etc . Quantitative bulk RNA seq , single cell RNA seq ATAC seq , CRISPR screen , and proteomic analysis DE , GO , clustering , data visualization , cellular velocity , delineation trajectory by machine learning etc . . Proven ability in computer programing , including R Bioconductor , MEFISTO , Seurat , Signac , edgeR , DESeq2 , Cuffdiff2 , ggplot2 , dplyr , tidyr , tidyverse and etc , python muon , panda , scanpy , numpy , matplotlib , gseapy , CRISPR seq , and etc , SQL , Jupyter notebook , as well as git version control systems github and etc . Hands on experience with HPC cloud based Linux system . Confocal Imaging Zeiss , Leica confocal Fluorescence , immunohistochemical techniques IF , IHC , ISH , RNA scope , multi parameter FACS , protein expression analysis Western blot , ELISA , genetic engineering CRISPR Cas9 , and statistical analysis . Proven scientific track record in systemic and computational biology research including multiple publications and journal review experience . Excellent scientific communication skills exemplified by various papers including first authored papers on Science Advance , Cell Report , and JCI , PubMed : https : www.ncbi.nlm.nih.gov myncbi ting.xie.1 bibliography public , presentations , and grant experience . Patented discoveries in lung disease . Proven ability to work independently and as a team player to collaborate with experimental scientists . Proven ability in project management , supervision , and mentoring of undergraduate students , junior postdocs , and technical staff . Skill : Single cell RNA seq ATAC seq , Spatial genomics , Proteomics , Epigenomics , multi omics Data Analysis , Python , R , SQL , Pyspark , SparkR , GATK , Hail , Linux Shell , Docker , Virtual Box , Bioinformatics , cloud based HPC Linux computing Lung Research , immunology , molecular biology , genetics , stem cells , mesenchymal cells , matrix biolog Confocal and EM imaging , 2D and 3D cell culture , Flow cytometry , Western Blotting . Technologies :",
"Senior Research Scientist . . As appears on paper , I am an experienced and skilled biochemist with competencies spanning targeted metabolomics , evolution , molecular biology and biochemistry . Beyond paper , I am a proficient and engaging spirit with contagious enthusiasm . I have always enjoyed compiling a huge amount of creativity into my workflow often bending the classical ways of experimental setups . Scientific key areas Protein chemistry Pathway discovery Enzyme design and optimization Technological key areas Heterologous expression and purification protein , metabolites Liquid chromatography and mass spectrometry HPLC , LC MS , LC QTOF MS MS Synthetic lipid systems Vesicles , Nanodiscs , microsomes . Technologies :",membrane proteins;engineering;expression
"Senior Research Scientist . . I am passionate about research that is relevant for pharmaceutical industries and public health . I am primarily experienced in structural biology and protein formulation . I have been working with different protein drugs and investigating their stability using variety of methods . During my personal and academic life , I became independent , very organized , and responsible . I adapt easily to a new work environment and I am very interested in working in multidisciplinary and multicultural teams . I am highly interested in learning new subjects that could aid me in becoming more versatile in my profession .. Technologies :",proteins;formulation;stability;structure
"Scientist . R D . I am a molecular biologist passionate about deciphering the function of proteins with a combination of structural and biophysical techniques . With previous pharmaceutical and industrial experience , as well as more than 7 years of research on challenging topics , I have gained profound expertise in gene cloning , protein expression , purification and characterisation . Throughout my previous work , I have always enjoyed trouble shooting and keeping my tasks and environment organised . I am familiar with working on parallel projects , where planning and prioritising is a must in order to meet deadlines . I love to collaborate with partners so that together we could reach a greater goal that can not be realised alone . I value creative solutions and enjoy learning new things . I approach problems in a systematic , meticulous manner . My colleagues often describe me as positive , supportive , resourceful and trustworthy . I look forward to using my knowledge and analytical mindset in my future job where I can further develop myself with new input and challenges . Should there be any questions , please feel free to contact me via LinkedIn or by email wangshu.jiang.b gmail.com . . Technologies :",proteins;characterization;expression;structure
Machine learning Software Scientist . In collaboration with the Swiss National Supercomputing Centre CSCS and the Swiss Data Science Center SDSC I am designing a new data processing architecture to process and compress automatically the large amount of data 40 GB s collected at the macromolecular crystallography beamline . . Machine learning computational thinking molecular modelling programming scripting data analysis data visualization scientific communication I am a machine learning scientist with a background in molecular modelling and machine learning . I love working in talented teams to solve complex problems using innovative technologies . . Technologies :,
"Senior Research Associate II . Generation of stable cell lines using CRISPR Cas9 and lentivirus transduction to validate the compounds developed by the company . Establish and perform in vitro cellular assays for target validation and compound testing . Generation of stable expression iPS cells using lentivirus and differentiation . I am a fast learner in a scientific environment , and proactive in addressing problems , with consistent follow through to meet goals . I also approach all tasks in an organized , methodical fashion and keep well organized , complete lab notes . I have strong work ethic and enjoy working in a fast paced , international , and multidisciplinary environment . Thanks to my experience in various laboratories and biotech companies , and thanks to my current position at CZ Biohub and my former position at Cairn Biosciences , I developed the following technical skills : . Molecular Biology : Cloning , Primer design , PCR , gel electrophoresis , BLAST , Nanodrop , DNA extraction . Cell culture , stable cell line generation , FACS . Mass spectrometry sample preparation and analysis using Perseus . High Content Screening : Optimization , use of lab automation liquid dispenser , Titertek plate washer , Biomek , analysis . Fluorescence and confocal microscopy . Digital droplet PCR analysis : determination of copy number variation . I have been also involved in the lab organisation of all the organizations I worked in . . Technologies :",
Chief Scientific Officer at Biotalys . . Nanobody Explorative Technologies NExT towards the next generation Nanobodies . Management of a Nanobody technology innovation portfolio . supervision of a team of technology oriented project leaders . outlining technology innovation strategy . managing academic and industrial collaborations . . Technologies :,antibodies;developing
"Senior Manager , Principal Scientist . . PROFESSIONAL STATEMENT Blends an extensive and accomplished academic background with successful industry experience to provide proven exceptional critical thinking , problem solving , and technical skills to employers . Expertise spans areas that include immunology , molecular biology , cell signaling , autoimmune disease , immuno oncology including CAR T cell therapy . Industry experience working in the areas of early research , lead identification preclinical , translational and QC clinical has been acquired in organizations at various stages of maturation from early Innovimmune to growing ICOS Corp to mature BMS , Novartis , Celgene which has provided me with a great variety of views of the drug development process and the challenges involved . KEY SKILLS Extensive molecular cloning experience and DNA RNA PCR based methods . Substantial flow cytometry expertise 13 colors most familiar with LSRII and LSRFortessa machines , intracellular , phopsho flow , sorting , proliferation , viability , etc . Vast array of cell based assay techniques see attached CV below for exhaustive list . Considerable background in a multitude of cell culture techniques and cell types , as well as co cultures . Transient and stable transfections plus viral transductions . Variety of in vivo mouse skills including induction of autoimmunity . Successfully led lead ID for an oncology drug program . Excellent written and presentation skills . AREAS OF EXPERTISE Immunology Molecular Biology Cell Biology Cell Signaling e.g. PI3 K , MAPK , NFkB , IP3 DAG , etc Chemokines Autoimmunity GPCRs NRs In vivo mouse Feel free to contact me : darrancronshaw gmail.com . Open networker to people in related professional fields or avocations see ' additional info interests ' in LinkedIn profile .. Technologies :",biologics;developing
Associate Professor . . . Technologies :,
"Head Biostatistics . NEXUS Personalized Health Technologies ETHZ , . Clinical Bioinformatics Unit : . Supervising a team of professional biostatisticians . Contributions as co PI or partner to grant applications . Management of data analysis projects . Our analysis portfolio is focused to : . anyOMICS analysis . Single cell analysis . Machine Learning , Deep Learning , AI . Clinical outcome prediction , biomarker discovery validation . Spectral , time series time to event analysis . High dimensional statistical modeling regression , classification , prediction . Data analysis for personalized and translational medicine . In my role as head of biostatistics I am leading a small team of professional biostatisticians within the technology platform NEXUS at ETH Zurich . In addition , I am a senior scientist with a biophysics and statistics background . I am passionate about squeezing out data to extract as much information as possible . My specialty is the analysis of high dimensional and complex data , single molecule or single cell data , and image analysis . Currently I am enabling personalized medicine by supporting clinical decisions using OMICS tools . In the past , In the past I was developing methods and instruments for high resolution microscopy , fluorescence spectroscopy , and high content screening . I have a 7 year industry experience in image based drug discovery and compound screening . . Technologies :",
Senior Scientist . . I am a research scientist with 10 years of experience in Cell and Molecular Biology . I am passionate about learning new things and techniques as well as employing my knowledge and skills to yield solutions to various challenges in science and technology to help people .. Technologies :,
"Special Consultant . . I am a curious , open minded , and PhD in molecular structural biology . I have eight years of hands on experience in recombinant protein production techniques and structural biology , 6 years of single particle cryo TEM experience . I am used to working both independently and in teams , making project related decisions , managing collaborations , and reporting results .. Technologies : CryoEM",proteins;expression;structure
"Scientific Investigator , Computational Biology . . Experienced Scientist with a demonstrated history of working in the research industry . Highly skilled data analyst with strong research background and diligent attention to details , ready to incorporate and investigate complex biological and cellular data to tackle different challenges in science . Excellent understanding of biological and pharmaceuticals data analyses including genomics , multi omics and network based drug discovery .. Technologies :",
"PhD Researcher at KU Leuven and Janssen Pharmaceutical Companies of Johnson Johnson . . PhD Researcher in Pharmaceutical Sciences . Currently working on the development of intrabodies to target Tau pathology in Alzheimer 's Disease . This project is a collaboration between the Laboratory for Therapeutic and Diagnostic Antibodies KU Leuven and the Neuroscience Department of Janssen Pharmaceutical Companies of Johnson Johnson Beerse , Belgium , co funded by VLAIO as a Baekeland mandate . . Technologies :",antibodies;idps;interaction
"Lead of Technology Development , Clinical Sciences and Interpretation . . Our mission at Jungla is to empower the precision medicine industry with quantitative genetic and genomic testing . We are inspired by patients , genomes and the innovative , cross disciplinary technology development . As such , our platform integrates advances in genomics , cell engineering , computational biophysics , and computer science to bring state of the art genome interpretation to patients . This work brings together advances in functional genomics , computational biophysics , cellular engineering , machine learning , security , and a high performance computing platform to deliver robust , comprehensive , and clear clinical guidance . We thrive on integrating diverse areas of expertise in cross disciplinary teams and innovation as new capabilities in clinical settings . If you are interested in what we are building , we d love to hear from you . I grew up in France and San Diego , and I spend my weekends cooking , running and tinkering with new technology .. Technologies :",
Senior Bioinformatics Research Engineer . . . Technologies :,
"Principal Bioinformatics Scientist II , Roche Sequencing Solutions . . Extensive 20 years algorithm development experience in Computational Molecular Biology . Recent accomplishments include : A novel algorithm for prediction of genomic Copy Number Variation based on continuous signal interpolation . It is sensitive to short variations down to 100 bps and has relatively low novelty rate . The algorithm became part of Revolocity sequencing technology built by Complete Genomics and its performance was presented at ASHG 2015 . Proprietary time efficient algorithm for MS MS unrestricted database search of peptides with unanticipated modifications . The algorithm was placed 2 nd out of 17 in the annual iPRG 2013 blind study . Areas of expertise : statistical methods for DNA and protein sequence analysis , NGS , large scale genomic variation , multiple sequence alignment , Hidden Markov Models , evolutionary inference , protein clustering , and MSMS spectrometry . Programming experience : C C , Perl , Python , MATLAB , Unix . . Technologies :",
"Senior Director , Computational Biology . . Solving the problems of the Bio Pharma Industry through research , analytics and hypothesis generation to extract high value information from public and proprietary data . I am a biologist with knowledge across computing , statistics and the drug discovery development process . I combine these in interesting ways to find solutions to challenging problems . Exceptionally organized individual contributor , team player or lead , able to prioritize and execute on multiple fronts on time and on target . Specialties : computational biology , bioinformatics , genomics , systems biology , pathway analysis , software development , R , Python , Perl , SQL , PL SQL , HTML CSS JavaScript , communication written and verbal , problem solving . Technologies :",
"Scientist II . Hepatitis B virus HBV and its subviral agent Hepatitis D Virus HDV are a major global health problem with 350 million people chronically infected worldwide of which about 700,000 die every year with HBV HDV related complications including liver cancer . To date , there is no functional cure for chronically infected patients . At Assembly Biosciences , I work on small molecule viral entry and assembly inhibitors , as well as immune modulators , to develop a cure for chronic HBV HDV infections . . Hepatitis B virus HBV and its subviral agent Hepatitis D Virus HDV are a major global health problem . At Assembly Biosciences , I work on small molecule viral entry and assembly inhibitors , as well as immune modulators , to develop a cure for chronic HBV HDV infections . Previously , I worked as an Assistant Scientist at the Morgridge Institute for Research in the lab of Dr. Paul Ahlquist where I worked with a highly advanced Nodavirus model system to study replication complex RC assembly , structure and function via a combination of cryo electron microscopy and biochemical techniques . A detailed molecular understanding of viral RCs is essential to find novel drug targets to inhibit the replication and spread of RNA viruses such as SARS and MERS coronaviruses , Dengue , Zika and Hepatitis C viruses . As a graduate research assistant at University of Wisconsin Madison in the lab of Dr. Dan Loeb , I studied the replication of HBV by fixed and time lapse fluorescence imaging techniques to track the viral components in cells during HBV replication . Our work led to crucial insights in the trafficking of viral core and polymerase proteins in cells and also highlighted a novel role for the viral polymerase at the mitochondria which can be explored for better drug design and eradication of the virus from chronically infected patients . Before that , I worked as an Application Specialist at Hemogenomics Pvt . Ltd , where I set up and maintained NAT nucleic acid testing lab facilities for blood banks in hospitals in Mumbai .. Technologies : CryoEM",proteins;structure
"Senior Manager . Advanced Analytical and Structural Chemistry CMC D D Small Molecule Analysis and Characterization LC MS , NMR and solid state characterization technologies . Project Management People Management Project Coordination Small Molecule Characterization Protein Analysis and Characterization Protein Stability and Biophysics Protein Formulation LC MS Hydrogen Deuterium Exchange Mass Spectrometry . Technologies : NMR",small molecules;characterization;developing
"Biochemist . . Interested in research areas of structural biology , protein design , biochemistry , and any other inspiring fields . Technologies :",proteins;engineering;structure
"Doctoral Researcher . University of Pittsburgh School of Computing and Informatics SCI fellowship recipient . Working under Dr. Yanshan Wang , on Clinical Natural Language Processing , Information Retrieval Extraction , Knowledge Discovery from Clinical Texts and Electronic Health Records EHRs Biomedical data mining from unstructured clinical data Designing natural language processing systems for clinical information extraction Building informatics frameworks for the secondary use of EHRs for clinical research . Doctoral Researcher , working under Dr. Yanshan Wang , on Clinical NLP and Healthcare AI research . Specialized in Information Retrieval Extraction , Text mining and Machine Learning in Clinical data science and Biomedicine . 5 years of experience in developing Healthcare AI models . Interested in NLP , Information retrieval , recommendation systems , causal inference , literature based discovery , knowledge graphs , fairness and explainability of machine learning models . Self directed engineer and Research scientist , who excels at driving new research ideas from conception and experimentation to production . A machine learning researcher who envisions a world of artificial intelligence and relentlessly works towards it . Kaggle : https : www.kaggle.com sonish2383 GitHub : https : github.com sonishsivarajkumar Twitter : https : twitter.com sonish sivaraj . Technologies :",
Head of Bioinformatics . . . Technologies :,
York Against Cancer 30th Anniversary Research Fellow in Cancer Informatics . . . Technologies :,
Undergraduate Researcher . Investigating mechanisms behind toxic protein accumulation . . Technologies :,
"Chemical Engineering Ph.D. Candidate . Co advised by Dr. Keith Keitz and Dr. Lauren Webb , I am researching ways to develop biosensing and therapeutic solutions for amyloid diseases such as Alzheimer 's Disease and Type II diabetes , which are a class of incurable diseases that are currently among the top 7 leading causes of death in the US . I am uncovering the mechanisms that lead to their toxicity , using in vitro model surfaces biomimetic self assembled monolayers SAMs , functionalized mesoporous silicas to control the structure of these amyloidogenic protein aggregates amyloid and bridge the gap to match structures observed in vivo . My goal is to classify these polymorphs to determine what fundamental structural and biochemical features shared across amyloid aggregates lead to their toxicity in these diseases , analyzing the observed structural polymorphs using infrared spectroscopy , fluorescence , microscopy AFM , cryo EM , and bioinformatics machine learning , structural class averaging . . . Technologies : CryoEM",idps;structure
Senior Informatics Sales Specialist . . . Technologies :,
"Kommunikationskonsulent . Projektansat til at f forfattet en l kker , omfangsrig portef lje med Innovation og Medborgerskabs mange fantastiske projekter . . S ger job tekst , projektkoordinering , borgerinddragelse , kulturanalyse , research , web m.m . Fuldtid deltid . stjylland . Kontakt mig p mettemu hotmail.com eller 28497245 . Tak Den korte version om en del af mig : Den gode historie er drivkraften i st rstedelen af det , jeg skriver . Jeg trives med at kunne bringe formidlingen i jenh jde , og synes det er virkelig effektivt , n r afsender og modtager indg r en form for dialog . Derud over sv rger jeg til at fors de kommunikation med humor , rlighed og uformelt glimt i jet Kan dog godt v re formel , n r jeg skal . Se bare : Jeg er cand.mag i etnografi og socialantropologi med sidefag i medievidenskab og visuel kommunikation , og har videreuddannet mig inden for formidling p nettet , b de i skrift , billeder og lyd p Danmarks Journalisth jskole tilsat en uddannelse som digital koordinator . Det betyder , at jeg har en bred tv rfaglighed : Tekstproduktion I d og konceptudvikling Borgerinddragelse Kommunikation ekstern og intern Afd kning af m lgrupper Research Evaluering Kundeservice Vejledning Det gode event Jeg kan alts arbejde med visuelle medier , kommunikation og formidling , b de med et kulturelt fokus og et kommercielt fokus . Derud over elsker jeg at projektlede Jeg har oparbejdet et god evne til at tilegne mig viden har arbejdet inden for flere forskellige brancher , hvor jeg har m tte s tte mig ind i , hidtil stort set , ukendte omr der . Derfor falder det mig i dag nemt , at lede et projekt fra A Z , som den selvhjulpne katalysator jeg er , og indhente den forn dne viden til at g re projektet vellykket .. Technologies :",
"Postdoctoral Researcher Project Group Leader . . Goal oriented professional with expertise in designing , organizing , executing and evaluating research projects . My approaches to solving research problems are creative and up to date with modern technology . I employ a wide range of different biochemical and biophysical methods , combined with protein structure determination by cryo electron microscopy , to uncover mechanisms underlying fundamental processes , such as replication , transcription and DNA repair . I also have experience in solving mechanisms of antiviral drugs , as well as designing high throughput assay for drug screening , such as the current effort to find novel inhibitors of coronavirus replication . I thrive in diverse , international and collaborative environments , as part of a team and or organizing and leading team effort . I enjoy communicating science , data and research to different type of audiences .. Technologies : CryoEM",proteins;structure
"Computational Chemist . Provide computer aid drug design support to help clients design , screening and optimize drug like small molecules . Develop and apply machine learning methods to generate drug like small molecules . . . Technologies :",
"Associate Computational Biologist . In my time at DFCI , I have contributed to the development of an NLP pipeline in Python to annotate the metadata of samples in the Gene Expression Omnibus . The pipeline utilizes a combination of standard NLP preprocessing techniques as well as an implementation of the Schwartz Hearst algorithm for identifying biological acronym expansion pairs in free text . To make effective predictions , the pipeline builds a directed acyclic graph from words in the text to standardized ontology terms and uses weighted edges for improved accuracy and decision making . I have also been working on a method to annotate single cell ATAC seq data using a Latent Dirichlet Allocation Topic Model trained on bulk ATAC seq data . The model is trained using PyTorch 's LDA module with Sklearn 's Logistic regression to predict cell types . The model is able to predict on single cell data with a 90 accuracy on test sets . . I 'm an Associate Computational Biologist at Dana Farber Cancer Institute in the Liu Lab . This past spring , I graduated from NYU Tandon School of Engineering with a B.S. in Biotechnology and Computer Science . During my time there , I worked as an Assistant Lab Technician in the Department of Microbiology at NYU Langone Medical Center , and became adept in laboratory techniques such as tissue culture , plasmid preparation , bacterial transformation , Western Blotting , DC isolation from mice , and viral titration . I also completed my Senior Honors Thesis in the Department of Translational Research , analyzing multi omic data from the Milieu Interieur Consortium . In my current position at the Liu Lab , I am further developing my statistical and software programming skills in R and Python and have taken courses in C , and am looking forward to growing and learning more in this position . Outside of my academic studies , I have a BA in Indian Classical dance and am avidly pursuing a career as a solo artist , in addition to work . I regularly perform , teach , and produce my own original choreography and content . Email : asd474 nyu.edu Phone : 908 267 1994 . Technologies :",
"Research Fellow . . I am currently working as a research fellow at Dana Farber Cancer Institute . I completed my doctoral studies in field of Metabolomics and NMR spectroscopy , from Indian Institute of Science , Bangalore . My undergraduate training was in Biological Science and Bioengineering from Indian Institute of Technology Kanpur . I have worked as a research assistant for an year in a Computational Systems Biology research group at National University of Singapore .. Technologies : NMR",
"Head of Immuno Oncology Research Unit I . Anti cancer drug discovery in the field of Immuno Oncology , project portfolio responsibilites . Overseeing and leading in vitro and in vivo pre clinical research and development activities from target discovery , through lead generation and lead optimization , to support early clinical development . Leading interdisciplinary project teams developing SMOL , PROTAC and BMOL cancer therapeutics . Preparation of submission relevant regulatory documents including Pharma Reports , Briefing Book , Investigators Brochure , IND . . During my 20 years of research and leadership at the top notch academic and industrial organizations my goal was always to make an impact on human life , with particular focus on delivering better anti cancer therapeutics to improve and extend the lives of cancer patients . . Technologies : Xray;ITC;AUC;NMR",molecular glues;developing
"PHD Student . Rotations in developmental biology , cell migration and cryo EM . Project focused on method development in cryo EM , establishment of new equipment on campus , development and optimization of sample preparation steps and imaging methods . Problem solving and support of fellow students . Aiding in science communication and outreach programs . Organization of the Young Scientist Symposium 2019 . . . Technologies : CryoEM",structure
"Scientific Researcher . Working in an exciting field of Neuroimaging Neuroinformatics . Highly motivated Research Professional with extensive experience and working knowledge in Virology , Molecular Biology , Immunology and Drug development practices . Optimize , troubleshoot and implement target specific assays for use in antibody and small molecule screening and functional characterization . Expert in all flow cytometry aspects and provide consulting services to major companies helping set up flow cytometry assays and trouble shoot issues regarding validation of the documents . Collaborate with Analytical Development and QC teams to complete method development reports , method validation protocols , by authoring or reviewing method validation related technical documents , statistical analysis of data , and reports . Review raw material testing assay development report , formulation characterization report and other technical reports if any . All activities to be done following global regulations i.e. ICH guidance , FDA EMA GMP Regulations , etc . . Technologies :",biologics;characterization;quality
Senior Research Associate . . . Technologies :,
"Director , Bioinformatics . . . Technologies :",
"Computational Biologist . Computational Biologist developing and applying computational methods to integrate functional genomic and biomedical data to make better drugs for patients . . I 'm currently a 5th year PhD student in David Gifford s lab , where I work at the interface of biology and machine learning . In particular , I have been working on developing and evaluating methods for identifying transcription factors that are involved in defining cell type using chromatin accessibility profiling to study the areas of the genome that are accessible or inaccessible in a given cell type . As an undergraduate , I was trained as a computer scientist but did my research in a biology lab that studied planarian regeneration . I worked on a wide array of projects that ranged from implementing search algorithms in C for a database to characterize unknown molecular components from planarian regulatory networks that were reverse engineered from experimental data , image analysis to count isopotential domains from whole body planaria images of membrane potential , to exploring training techniques of artificial neural networks that increase robustness of post training perturbation of the model parameters . My goal is to apply my expertise in bioinformatics to drug discovery and human health by working closely with experimental collaborators to combine new and publicly available data to answer unsolved problems . . Technologies :",
"Senior Scientist , Data Sciences . . Computational Biologist with 5 years of experience in machine learning , predictive modeling , and algorithm development .. Technologies :",
"Senior Scientist . . Applied research scientist with broad industrial experience in using mathematical modeling and simulation to analyze the behavior of complex biological systems , most recently in drug discovery and development . Background in computer science , mathematics , and biology . Specialties : mathematical modeling of cellular signal processing ; population pharmacokinetics pharmacodynamics ; clinical trial simulation ; Disease areas : cancer , cystic fibrosis , sickle cell disease .. Technologies :",
"Associate Director , Data Science Bioinformatics , Oncology R D . . Computer Science PhD with experience in Bioinformatics , Machine learning deep learning , cloud computing and web development . Worked in multiple interdisciplinary projects involving genomics and metagenomics applications . Received the 2018 outstanding student award in multidisciplinary research . Fluent in multiple programming languages including python , javascript web applications , nodejs , java , C , typeScript , HTML , Bash among others .. Technologies :",
"resident physician scientist , UCLA Neurosurgery . . . Technologies :",
"Deputy Director and Director of Research of the Bayes Centre . . Between 2008 and 2011 , I completed a doctorate in Computational Biology at the University of Oxford . The core of my doctoral research was the development of computational methods for the simulation of ventricular cardiac electrophysiology . My contributions became the basis of multiple subsequent Ph.D. projects and were pivotal for the success of the EU FP7 grant VPH preDiCT . During the project we had the opportunity to work closely with pharmaceutical companies in order to explore how mathematical modelling and simulation can be brought into their drug cardiotoxicity research pipeline . My work was also selected for presentation at the Heart Rhythm 2011 conference , one of the biggest international meetings on cardiac science , including basic , translational , and clinical research . In 2011 , I joined the Centre for Mathematics and Physics in the Life Sciences and Experimental Biology CoMPLEX , UCL , where I worked on characterising the relationship between haemodynamics and vascular remodelling with a combination of computational and experimental methods . My work featured in the New Scientist magazine 2906 , Feb 2013 and has been published in journals and international conferences . During this time , I realised that a strong interaction between experimental and computational techniques is required in order to address the most pressing questions on how blood vessels respond to normal and abnormal flow conditions during development and disease . In 2015 , I joined the The University of Edinburgh with a prestigious Chancellor s Fellowship where I established my first research group at the Centre for Medical Informatics , Usher Institute . Promotion to Senior Lecturer followed in 2019 . The research activities of my group have been supported with funding from Fondation Leducq , European Commission , EPSRC , MRC , British Heart Foundation , The Alan Turing Institute , and Diabetes UK . In May 2021 , I was appointed Deputy Director of The Bayes Centre , the University s innovation hub for Data Science and Artificial Intelligence , where I am also responsible for research strategy and delivery through my role of Director of Research . You can learn more about The Bayes Centre and the opportunities it provides on Education , Research , Entrepreneurship , and Industrial Partnerships here : https : www.ed.ac.uk bayes . Technologies :",
"Senior Scientist . . A professional who has expertise in the fields of molecular biology , protein biochemistry , antibody engineering and equally well trained as application scientist for modern Flow cytometers . A team player , high level of motivation as well as intercultural understanding characterizes my work style . . The following are highlights of my key skills : . Excellent organizational , analytical , and systematic troubleshooting skills . Concise communications , acting as an interface between cross functional teams . Efficient and creative when it comes to experimental challenges . Team player with a synergistic attitude towards my team . I believe in shared knowledge and gained skills . I can also focus on individual projects with minimal direct supervision . Innovative , independent , driven , and results oriented . Flexibility to adapt to evolving requirements . Effective time management . Experienced as Field application scientist and trainer for flow cytometer based EDIM Epitope Detection In Monocytes test . Great technical competence in molecular biology lab and equipment handling . Highly experienced in molecular cloning techniques mRNA isolation , cDNA preparation , PCR , site directed mutagenesis , generation of expression constructs , Cloning , expression and characterization of proteins . Also involved in devising a protocol for non invasive , cost efficient and early detection of Alzheimer s Disease associated pathological changes . Cell culture techniques adherent and suspension . Hybridoma technology Monoclonal antibody generation and their characterization . Recombinant antibody techniques generation of synthetic plasmids with recombinant antibodies genes for recombinant antibodies production in mammalian cell lines , E. coli . Antibody screening from semi synthetic and synthetic libraries synthetic Shark libraries using Yeast display technique and synthetic cameloid library using Phage display techniques , high throughput panning and sorting procedures . Long standing experience with modern flow cytometers . Staining of whole blood PBMCs . Fluorescence microscopy RCMIA Rare Cell Multiprobe Imaging Analyzer . Technologies :",
"Computational Biologist . Develop pipelines , create visualizations for the analysis of RNA Seq data . Outstanding Problem Solver with strong analytical , statistical and programming abilities Solve complex biological problems by designing and implementing novel algorithms and creating analysis pipelines . Identify biologically meaningful subsets in large data sets using statistical and machine learning techniques . Excellent listening skills . Enjoy creating visualizations to effectively communicate results . Quick learner , self starter , collaborator . Computer Languages Tools Used Professionally Most recently used first : Linux including bash scripting , R , Matlab , Perl , Lisp , Java , SQL , C Biological Data Types Used : NGS , genome chip , microarray expression , flow cytometry and mass spectrometry data . Technologies :",
"Founder , Consultant and Scientist . Five years supporting 10 Pharma and biotech companies with R D pharmacology : Candidate selection , data analysis interpretation troubleshooting , scientific communication , education and training . Aiding life science companies Promega , Montana Molecular , PerkinElmer develop novel assay technologies and identifying new applications for existing products . Developing data analysis platforms for companies to streamline and simplify their pharmacology analysis and data visualization . . My passion is helping people solve problems . In 2016 I founded the consultancy company Pharmechanics LLC to support pharmaceutical , life science and academic scientists in developing new therapeutics and understanding drug target systems . Services include strategic consulting , data analysis troubleshooting especially in lead optimization candidate selection , and scientific communication . For five years I have supported Pharma and biotech clients with R D pharmacology , enabling projects to move forward and the best drug candidates to be selected . With a wealth of experience of in vitro pharmacology in the pharmaceutical industry I can help you resolve the issues that are creating challenges in your drug discovery project . For life science companies developing novel tools for drug discovery , I identify novel utilities and create new data analysis methodologies to increase the application and value of the products . For example , working with Montana Molecular we have developed new kinetic analysis platforms for biosensors that enable routine quantification of the kinetics of signaling for drug discovery . For the scientific community , I develop new open source data analysis methods that enable investigators to analyze their data in new ways , to extract extra value from new pharmacology methodologies . I run workshops and seminars to train scientists in pharmacology data analysis , including for the National Institutes of Health Assay Guidance Manual . I have published 30 first senior author papers on drug discovery , molecular pharmacology and data analysis . My scientific specialty is the kinetic analysis of drug action . I am recognized for applying kinetics to the development of effective therapeutics , e.g. GPCR antagonists , and for developing new kinetic analysis methods . Before founding Pharmechanics in 2016 , I was a pharmacology leader in the pharmaceutical industry for 15 years at Neurocrine Biosciences , guiding the in vitro biology for 30 drug discovery campaigns , especially on GPCRs and transporters . My postdoctoral and postgraduate research focused on molecular analytical pharmacology of GPCRs . Contact me at sam.hoare pharmechanics.com .. Technologies :",
"Sr . Bioinformatics Scientist . Designed and implemented a Wafer Request System Web App . Tools used : Laravel , Html , CSS , Javascript , JQuery , PHP , MySQL , MongoDB , JSON Developed tools for analyzing RNA seq data . Tools used : C , Qt Developed algorithms and pipelines for designing probes and simulating synthesis for micro arrays . Tools used : C , Qt Developed a pipeline and a software including front and back ends for designing micro array chip masks . Tools used : C , Qt , Python , Boost , Ruby , KLayout Designed and developed databases , web applications , and user interfaces for building Laboratory Information Management System for NGS preparation pipeline . Tools used : MySQL , Laravel , PHP , Html , CSS , Javascript , JQuery , XML , JSON Developed algorithms and effective software tools for image de skewing Tools used : OpenCV , Visual Studio , C , Qt , Python , NumPy , ImageJ Used Tribe Code software and whole genome NGS data from individuals for inferring their ancestry Additional tools used in this analysis : Samtools , BWA , Bowtie , Blast , GATK Tookit . I have a great passion in understanding biology based on analyzing genomic data . To address this , over many years I developed a wide spectrum of skills and experiences . Particularly , I developed state of the art computationally tractable algorithms , statistical methods and models , designed and implemented efficient software tools using various computer programming languages . I applied my developed tools to various genomic data sets from HIV , human , and oysters populations . In addition , I gained strong skills in effective design , problem solving , self directing , and leading projects . . Technologies :",
Scientist . . . Technologies :,
"Biacore Field Application Specialist . . Over 20 years experience in Drug Discovery with 2 major Pharmaceutical companies with a proven track record of supporting GPCR , kinase and neurotransmitter transporter projects from assay development through to late stage optimisation . . For the past 9 years have specialised in SPR with a strong focus in small molecule and fragment based drug discovery whilst working at the Beatson DDU and with a variety of targets and molecules whilst working with 2 successful CRO 's . Specialties : Areas of expertise : . SPR working with small molecules and larger macromolecules . Fragment screening using SPR . Biacore 8 K , B4000 and T200 SPR instruments . Cell culture management . High throughput screening cell supply . Developing and implementing cell based assays utilising a broad range of platforms including fluorescence , luminescence and radio isotopes . Line management . Preparation of client proposals and costing . Planning and managing projects . Technologies : SPR",proteins;small molecules;interaction;screening
"Statistician . . Analysis : Expertise in the use of statistical designs and analyses , hypothesis testing ANOVA , multiple comparison tests , parametric and non parametric , categorical data analysis , statistical process control , sampling plans , regression methods , multivariate techniques , measurements analysis , experimental and sample design , simulation and probability theory . Tools : Influence the use of statistical tools across the organization to drive more efficient use of data and better decision making . Thus , solid and demonstrable experience in quantitative and statistical analysis with a clear understanding of statistical and quantitative methods . Resourcefulness : Leverage internal and external resources to identify , implement , and sustain new ways to mine , analyze and interpret data to better enable the organization to deliver against required business results . Collaboration : Collaborate with scientists , biologists , statisticians , and chemists to produce client reports , peer reviewed publications . Consult with members of the scientific team to ensure accuracy of data analysis and graphical presentations . Research : Remain current on advances in lipid metabolism and protein metabolism , and on the relevant disease literature to provide context and background for internal research aimed at developing diagnostics for diabetes and cardiovascular diseases . Communication : Effectively translate statistical concepts and issues to non statistical audiences . Interpersonal : Good team player , great business ethics , and skilled at interacting with people . Computer : Languages SAS , S plus , R , Minitab , Matlab , C , and Pascal , Operating Systems Windows , Unix , Applications MS Office . Specialties : Assist with experimental design and statistical analyses appropriate for diagnostic assay development . Statistical programming and report writing . Collaborate and assist with biomarker discovery and validation efforts to facilitate the migration of diagnostic prognostic projects from discovery to development and manufacturing as regulatory approved commercial products .. Technologies :",
"Bioinformatics Scientist . 1 Provide bioinformatics and biostatistics support for biomarker discovery . 2 Develop bioinformatics analysis and visualization pipelines for biomarker discovery . . Boinformatics and Biostatistics 1 Inter discipline : Bioinformatics , biostatistics , mathematics , and computer science . 2 Algorithm development and statistical computational skills for large scale sequences and microarray . 3 Computing support for scientists from biology and medicine . 4 Developing bio computing tools and pipe lines to process , visualize and analyze large scale data : Sequences and microarray for biomarker discovery , by using R , BioConductor , Tcl Tk , Rstudio Shiny rCharts HighCharts , Spotfire , and LAMP Linux , Apache , MySQL , PHP Perl Python .. Technologies :",
"Bioinformatics Manager . . Proven research scientist with solid track of machine learning , Bioinformatics and software engineering R D , produced patents and world class publications in addition to commercializing research into products . . Technologies :",
"Director CMC , Analytical Development and Formulation . Department head for Analytical Development and Formulation Development of stem cell derived ATMPs . Building of the department , expansion of analytical capabilities and procedures to support CMC development . Giving guidance for CMC development strategies for ATMP programs . Due Diligences for new ATMP products . Drug Product specification owner and definition of analytical control strategies for a variety of clinical indications . Development of tech transfer approaches and guidance for transition of CMC technologies into GMP environments . . Pharmaceutical product development professional with experience in the CMC development of a variety of biotechnological products , ranging from therapeutic antibodies and vaccines to therapeutic oligonucleotides and cell therapy .. Technologies :",biologics;formulation;quality
"Senior Development Scientist . Subject matter expert on APIs and enzymes produced from E. Coli and CHO cells Involved in multiple outsourced projects ranging from pre clinical to phase 3 Part of CDMO assessments , evaluation and recommendations for production of protein or polynucleotide based APIs Collaborating with and supporting CDMOs during technical transfers , development and productions Providing technical overview of CDMO performance for project management team Downstream CMC process responsible for ATMPs such as plasmid DNA , mRNA and AAVs Setting up in house laboratory to perform process development on pDNA and mRNA . Responsible for development of downstream purification processes for therapeutic proteins , enzymes and polynucleotides pDNA and mRNA Working close together with global CMO and CDMO 's Core skills within protein expression and purification , peptide synthesis and bioconjugation Hands on experience with protein peptide polynucleotide chromatography and filtration technologies Involved in ATMP projects within CMC API development . Technologies :",enzymes;proteins;developing;expression
Senior Research Associate . Biomedical engineering and Bioengineering . . Technologies :,
Principal Scientist I . . . Technologies : Xray;NMR,
"Researcher . . Qualified Ph.D. Scholar in biotechnology has expertise in protein biology , molecular biology , biochemistry , biophysics , computer literacy with 9 years of working experience to carry exceptional and extended studies . Specialities : Proficient in mammalian cell culture suspension adherent , insect and bacterial cell culture , virus generation . Expert in protein both membrane and soluble proteins purification from mammalian or bacterial cells of recombinantly expressed protein or a native protein . Protein structure solution using X ray crystallography , and cryo EM techniques . Experience of team leadership quality , expert advice on collaborative projects , good communication , and presentation skills , project streamline and management skills . Skilled in independent project designing , method development , scientific writing . Working experience on international and national projects . Besides research , I do poetry and enjoy writing in my free time . The constant urge to address challenging questions , observe and solve problems encouraged me to get involved in the science field . . Technologies : Xray;CryoEM",membrane proteins;proteins;structure
"Associate Professor of Biological Engineering . . Biology computes ... from individual cells deciding how to differentiate during development , to social insects coordinating their actions when scavenging for food ; the ability to perform complex computations and process information enables life . I head up the Biocompute Lab at the University of Bristol , which explores the molecular scale mechanisms that individual cells and groups of cells use to make sense of their world . We apply tools and methods from the field of synthetic biology to create new living systems from the ground up . By studying these artificial systems using novel techniques we are developing based on sequencing , microfluidics and computational modelling , we aim to better understand the rules governing how biological parts are best pieced together to perform useful computations . Understanding the computational architecture of cells opens new ways of reprogramming them to tackle problems spanning the sustainable production of materials to novel therapeutics . It also provides key insights into how biology controls the complex processes and structures sustaining life .. Technologies :",
"Scientist Cell culture process development . Upstream development project lead for a fragment antibody process mammalian cells , CHO : . supervise and coordinate process development and process optimization activities matrix environment . ensure toxicology production GLPs . coordinate technology transfer to pilot scale production . support CMC regulatory filings . Protein purification : . affinity and ion exchange chromatography . Bio analytics : . support upstream development activities with the analysis of in process monitoring samples . HPLC for cation exchange , affinity and size exclusion chromatographies . RP UPLC for amino acid analysis . capillary gel electrophoresis . High throughput liquid handling system TECAN : . focus on increasing the lab performance for routine activities . bridging with lab scale methods in place e. g. , sample preparation for analytics . development of enzymatic assays for the analysis of cell metabolites . development of antibody mini purifications . training of end users and support . Implementation of electronic laboratory notebook : . focus on gain in time efficiency for data capture , data trending and searchability as well as on data integrity . cross functional collaboration . . . Biotechnology engineer with 5 years experience in biopharmaceutical companies . Specialized in the QbD based development of mammalian cell culture upstream processes . Knowledge in protein purification and bio analytics HPLC , UPLC as well . Develop and implement purification and analytical methods on high throughput liquid handler . Develop and implement of an electronic lab notebook within the UPS department , in alignment with the vision of the global team . Technologies :",antibodies;developing
PHD Student . Investigation of membrane protein structure and function by Cryogenic electron microscopy cryo EM and biochemical biophysical approaches . . . Technologies : CryoEM,membrane proteins;characterization;structure
"Senior Scientist . Developing novel computational methods to discover drugs for rare diseases . . Computational Science Engineering Ph.D. with research experience in parallel computing and computational biology . Worked on techniques to improve genome assembly using NGS paired reads . Proficient in C , Open MP , MPI , Python . Currently working on designing methods to improve drug discovery at Unravel biosciences .. Technologies :",
Researcher . . Ph.D. in biophysics . Open to works from both academia and industry on biophysics and biochemistry techniques .. Technologies :,
"AD Senior Principal Scientist . . Specialized Skills Process Modeling : Experienced in the implementation of theoretical and simulation techniques to perform analyses of chemical and biochemical phenomena at the atomistic , mesoscale , and continuum levels . Programming : Knowledge of Shell Scripting , Perl , Fortran , Python and C. Proficient in the use of specialized molecular simulation packages e.g. , CHARMM , GROMACS and AMBER , CADD tools e.g. , Schrodinger Suite , docking programs e.g. , Glide , Flexx , Autodock Vina , ADME predictors e.g. , ACD Suite , ChemSilico , data centric programing tools e.g. , MATLAB , and high level engineering software .. Technologies :",
"Senior Associate Scientist level 3 . . Surface Plasmon Resonance SPR on ProteOn XPR36 , Biacore T100 and MASS 2 . Bio Layer Interferometry BLI on Octet RED384 . Kinetic Exclusion Assay with KinExA 3200 with autosampler . Antibody Phage Display Technology . Nanobody Phage Display Technology . AlphaScreen , ELISA . Multiplex screening using iQue IntelliCyt R Sartorius and FLEXMAP 3D Luminex corp . . Flow cytometry using iQue IntelliCyt R Sartorius and MACS Quant 10 Myltenyi Biotec . Lab Automation . Technology Transfers throughout Europe . Technologies : BLI;SPR;ALPHA SCREEN",antibodies;small molecules;interaction;screening
"Staff Scientist . . Experienced biochemist and neuroscientist with interests in neurodegenerative disease biochemistry , biomarkers and drug design . Critical thinker with an eye for detail . Recognized for research through awards including pre doctoral and post doctoral training grants from the NIH , the Outstanding Young Alumni Award from The Albany Academies , the 2012 Mazz Prize from the UCLA Department of Neurology , a Rapid Grant Award from the UCLA Claude Pepper Older Americans Independence Center and the UCLA Clinical and Translational Science Institute , the 2013 Young Investigator Award from the California Southland Chapter of the Alzheimer s Association , and the 2017 Turken Research Award from the UCLA Easton Center for Alzheimer 's Research . Technical expertise in : Biochemical : Protein cross linking , protein electrophoresis , continuous protein electrophoresis , recombinant protein expression from E.coli , HPLC FPLC and other chromatographic techniques . Microscopy : Transmission electron microscopy , scanning electron microscopy , atomic force microscopy , light microscopy , fluorescence microscopy , confocal microscopy . Spectroscopy : Fluorescence , circular dichroism and optical absorption spectroscopy . Molecular biology : cloning , nucleic acid isolation , PCR , site directed mutagenesis , and western blot , antibody characterization . In Vivo animal models : Wild type and trangenic animal models for mixed demetia microvascular stroke and Alzheimer 's disease , neuronal cell isolation , single cell population selection . Specialties : Neurodegenerative diseases including extensive experience in Alzheimer 's disease and Parkinson 's disease , white matter stroke , amyloid protein oligomerization and aggregation , protein purification , heme proteins , protein biochemistry , biophysical characterization , protein folding and molecular biology .. Technologies : CD",idps;expression;screening;stability
"Principal Scientist . . Data scientist and machine learning expert focusing on data analysis . Experience in bioinformatics analysis and artificial biological systems ALife . Experience in data analysis , statistical analysis and machine learning feature selection , rule extraction , classification and clustering to analyze big data . Looking to utilize my analytical strengths and grow my technical skills within an organization that rewards dedication , success , and satisfaction . Specialties : Machine Learning , big data , statistical analysis , Artificial life , Multi agent systems , Evolution , Ecological Modeling .. Technologies :",
"Professor of Bioinformatics . I am currently Professor of Bioinformatics and Head of the Bioinformatics Group in the Department of Computer Science . I am also Director of the Bloomsbury Centre for Bioinformatics , which is a joint Research Centre between UCL and Birkbeck College and which also provides bioinformatics training and support services to biomedical researchers . My appointment is held jointly with the Department of Structural and Molecular Biology . . I received my B.Sc . in Physics from Imperial College and then went on to do an M.Sc . in Biochemistry at Kings College London , followed by a PhD in computational biology at University College London starting in 1989 . After completing a Wellcome Trust Biomathematics Fellowship at UCL , in 1995 I was awarded a Royal Society University Research Fellowship to allow me to set up my own lab at the University of Warwick . In 1999 , age 32 , I took up what was apparently the first Chair of Bioinformatics in the UK , at Brunel University . In 2001 , I was appointed Professor of Bioinformatics at University College London a joint appointment between the departments of Biochemistry and Computer Science . I am also currently the Director of the Bloomsbury Centre for Bioinformatics , a joint research centre between UCL and Birkbeck College . My lab aims to develop and apply state of the art mathematical , statistical and computational techniques to problems now arising in the life sciences , particularly those driven by the post genomic phase of biological research . I am the author of a number of very well known bioinformatics applications and web servers : THREADER , GenTHREADER , PSIPRED and MEMSAT . I was also involved in the early development of the CATH protein structure classification scheme developed at UCL . Although I have consulted for a few different companies , including GSK , my main industry experience was as a co founder of Inpharmatica Ltd. , which was founded in 1998 as a spin out company from University College London . The company used a combination of bioinformatics and chemoinformatics to look at the relationships between the structure and function of proteins , and the binding of chemical groups to these proteins leading to the discovery of novel drugs . The company was acquired by Galapagos NV in 2007 . Specialties : Structural bioinformatics , machine learning , algorithm development , high performance computing , GPGPU techniques , genome analysis , Hidden Markov Models , Support Vector Machines SVMs , neural networks , text mining . Technologies :",
"Undergraduate Bioinformatics Researcher . Current project on improving the Mutational Signatures refitting tool SigProfilerSingleSample under Dr. Ludmil B. Alexandrov , PhD avg . 15 hours week of volunteering o Benchmark all existing Mutational Signatures assignment tools o Execute result data qualitative and quantitative analysis to target the best performing tools for improvements on the algorithm of SigProfilerSingleSample tool from the Alexandrov Group . Incoming Master of Biomedical Informatics student at Harvard University . Skilled in computer science algorithms C , C , Java , Python , R , Swift and software development . Strong engineering background in biology and bioinformatics while pursuing a Bachelor of Science focused in Bioengineering : Bioinformatics from the University of California San Diego . Currently seeking SDE MLE interns jobs . . Technologies :",
"Scientist at Air Force Research Lab . . I am devoted to aiding the search for the next generation of rechargeable batteries with various electron microscopy techniques , including cryogenic electron microscopy . I 've been pivotal in bringing Sandia 's cryo EM labs online and developing its unique cryo EM procedures . Please reach out to me if you 'd like to become a user of the cryo EM suite or any of Sandia 's TEMs . My graduate work in the department of Materials Science and Engineering at North Carolina State University involved resistance degradation mechanisms of commercially relevant titanates , TiO2 , SrTiO3 and BaTiO3 and their relationship with point and linear defects . My interests include energy storage materials , electron microscopy , in situ electron microscopy , and device failure analysis .. Technologies : CryoEM",
"Director of Bioinformatics . At a high level , I manage and analyze data generated from human samples resulting from clinical trials using the protein microarray platform and to work with clients to plan and execute specific projects . ADI is a contract research organization CRO that analyzes clinical sample data in close collaboration with clients to plan projects , and then ADI executes the entire project in house . The steps that I manage for each project include initial project planning and discussion of primary and secondary hypotheses to be tested , statistical analysis plan SAP , experimental design , internal data quality assessment and experimental repeats if necessary , automated generation of reproducible report executing the SAP , and communication of results to clients . I develop and maintain software to automate as much of the analytical pipeline as possible , including : 1 optimization of experimental designs to minimize the effects of technical variation on statistical analysis and conclusions and to maximize sensitivity of detection 2 data extraction and format transformations 3 generation of reproducible HTML based reports as primary deliverable for clients Other frequent activities outside of the regular project cycle include : 1 Diagnosing technical problems from data irregularities and patterns . 2 Designing R D experiments to test theories on observed technical issues . 3 Curating datasets for training and testing prediction methods , applying statistical and machine learning models e.g. support vector machines , generalized linear models , and performing cross validation to estimate generalization accuracy of multi biomarker models . 4 Providing training in programming , statistical analysis , data visualization , and the protein microarray technology to scientists and technicians within the company and to visiting researchers . . . Technologies :",
"Director of Advanced Research Computing . . Research computing strategy High performance computing Research facilitation enablement Service development delivery Solution design Opportunity creation leverage Leadership and management Business case development , financial planning and budget management . Technologies :",
"Utredare . Verksam vid Enheten f r Medicinteknik , inom gruppen Regelverk och v gledning . Driven , ambitious and result oriented senior operations leader scientist with almost 20 years of experience from work within the industry and university sectors . PhD in biophysics and MSc in medical radiation physics . My experience from research and development stretches from clinical trials of diagnostic imaging methods in neurology , oncology and cardiology to basic research in protein chemistry and spectroscopy . Main areas of interest : Product development , project and operations management within the Life Science and Healthcare areas with focus on science and technology . Collaboration in multidisciplinary , international project teams . Specialist areas : Medical imaging methods for anatomical and functional diagnostics CT , MR , PET , SPECT Data processing and image analysis Farmacokinetic modeling and simulation Medical physics and dosimetry Spectroscopic methods and measurement technology Application areas : Neurodegenerative diseases , e g Alzheimer 's disease Cancer tumor detection , quantification and therapy monitoring Heart failure In vivo pharmaceutical imaging trials of the brain Structure , dynamics , folding , interaction , and aggregation of proteins Good communicator in writing and speech with 20 publications in scientific journals and numerous presentations at international conferences and meetings . Experience from teaching and supervision .. Technologies :",proteins;developing
Research Chemist . . . Technologies :,
"Senior Director , Bioinformatics Scientific Computing . . Experienced bioinformatics professional with expertise in several areas of genomics and technology . Proven problem solver with the flexibility to efficiently accomplish a variety of tasks in an individual or team setting , demonstrated proficiency in multiple operating systems and in knowledge of computer software and programming , and effective communication skills in interaction with a variety of professional educational levels .. Technologies :",
"Senior Research Scientist . . Experienced Researcher with a strong background in enzyme kinetics . Experienced and skilled in biophysical characterization , in protein purification and heterologous expression in bacterial and fungal cells . Skills : protein chemistry and stability nDSF , TSA , enzyme assays and kinetics , structure activity relationships , protein purification , chromatography HPLC , IC , biophysical characterization proteins , calorimetry in the biophysical science DSC , TAM , molecule interactions MST , ITC , lab automation incl . liquid handling , data analysis and development of workflows using Python .. Technologies : ITC;DSC;MST",enzymes;proteins;characterization;expression;interaction;stability
"Scientist II . . A highly motivated Ph.D. scientist with a background in the field of cancer biology , neurobiology , miRNA and Exosomes . Have independently designed , executed , analyzed , and published data from hypothesis driven research projects . Published research articles in peer reviewed high visibility journals , including Molecular Cancer therapeutics , Molecular Neurobiology , JBC etc . An effective collaborator and a team player with excellent verbal and written skills and strong interpersonal skills . Track record of quickly adapting and mastering diverse research areas and techniques . Skills include Cell culture , Molecular and Cell Biology techniques ; Anchorage and Suspension Cell Culture ; Primary Culture ; Transfections ; siRNA gene silencing ; miRNA studies ; Exosomes isolation and characterization ; Cell based assays ; microscopy ; Western Blotting ; Immunostaining ; Immunoprecipitation ; FACS ; RNA , DNA and plasmid isolation ; qRT PCR ; xCellligence RTCA assays , Transformation ; Hybridoma culture ; monoclonal antibody production , handling mice . Let s Connect E mail : navjotshah gmail.com . Technologies :",antibodies;expression
"Vice President . VP of Therapeutic area focusing on Inflammation , Immunometabolism , Pain , and Regenerative medicine . We aim to discover innovative medicine with curative potential in cardio metabolic , women s health , respiratory and liver end organ damage . Apply traditional , new , novel modalities , cell gene therapy , as well as digital medicine to bring medicines with curative potential to patients . Apply AI and ML to speed up target identification and drug discovery peocess . . Leading and portfolio management of a team of 50 scientists and managers focusing on Inflammation Immunology , Pain , and Tissue repair regeneration . Applied traditional small molecule , new peptide antibody , and novel PROTAC , X Chem modalities , as well as cell gene therapy to bring medicines with the curative potential to patients . Experienced in Machine Learning ML and Artificial Intelligence AI in discovery research , as well as digital medicine Experienced Drug hunter in broad modalities in Alzheimer s disease , metabolic diseases , diabetes , obesity , and NASH , with track records . Deep and broad experience and expertise in Biomarker research and implementation of precision medicine strategy in metabolic , CV Inflammatory diseases , pain , and Alzheimer 's disease . Broad experience in international regulatory affairs . Excellent communication skills and strong network in academic Biotech environment .. Technologies :",molecular glues;small molecules;peptides;antibodies;developing
"Principal Scientist , Crystallography . Providing crystal structures to drug discovery project teams . Managing and developing global structural database . . Experienced Industrial Protein Crystallographer . Wide project knowledge . Specialised in apoptosis and kinase signalling targets in oncology . Discovery of Mcl 1 specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia Nature communications 9 1 , 1 14 216 2018 Crystal structure of DNA recombination protein RuvA and a model for its binding to the Holliday junction Science 274 5286 , 415 421 196 1996 Crystal structure of E. coli RuvA with bound DNA Holliday junction at 6 resolution Nature structural biology 5 6 , 441 446 170 1998 Development of a novel B cell lymphoma 6 BCL6 PROTAC to provide insight into small molecule targeting of BCL6 ACS chemical biology 13 11 , 3131 3141 65 2018 Structure based design of non natural peptidic macrocyclic Mcl 1 inhibitors ACS medicinal chemistry letters 8 2 , 239 244 53 2017 Using isoelectric point to determine the pH for initial protein crystallization trials Bioinformatics 2015 , 1 8 , doi : 10.1093 bioinformatics btv011 35 2015 Computational design of epitope specific functional antibodies Cell reports 25 8 , 2121 2131 . e5 30 2018 Analysis of crystallization data in the Protein Data Bank Acta Crystallographica Section F : Structural Biology Communications 71 10 20 2015 A manual low cost protein crystallization plate jig for in situ diffraction in the home laboratory D Hargreaves Journal of applied crystallography 45 1 , 138 140 13 2012 Antibody fragments structurally enable a drug discovery campaign on the cancer target Mcl 1 Acta Crystallographica Section D : Structural Biology 75 11 , 1003 1014 2 2019 Evaluation of the therapeutic potential of phosphine oxide pyrazole inhibitors in tumors harboring EGFR C797S mutation Cancer Research 79 13 Supplement , 4451 4451 1 2019 Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S Mediated Resistance Journal of Medicinal Chemistry 2021 . Technologies :",proteins;interaction;structure
Senior Bioinformatics Scientist . . . Technologies :,
Senior Scientist . . . Technologies :,
Researcher in Structural Biology . Studying protein and protein RNA complexes using electron cryo microscopy cryo EM . . Researcher and engineer with ten years of experience in the area of molecular biophysics with work in both computational and experimental structural biology . Skills : Problem solver that think outside of the box Dissecting and visualizing complex data Learning new methods and tools . Technologies : CryoEM,nucleic acids;proteins;structure
". . Software engineering , CS in general , pivoting towards application in biosciences . I held previous positions aiding in analysis of software predicting tumor heterogeneity Python and image analysis for synthetic vesicles under cryogenic electron microscopy cryo EM trying to identify lipid rafts Mathematic . I would benefit greatly from more practical experience in CS and hope to establish some symbiotic relationship .. Technologies : CryoEM",
"Data Science Product Manager . . Throughout my career my interest has remained in exploration and advancement of technology , irrespective of the field : from modelling complex biological systems , gene regulatory networks and small molecule interactions , to developing financial trading strategies operating on cryptocurrency exchanges and product bidding strategies focused on search engine optimisations . My goal is to build upon my experience and knowledge in consumer facing industries and aid in the planning and development of novel tools and products .. Technologies :",
"Director of Precision Medicine and Computational Biology Data Science . . I have a strong background in computer science and statistics . I built up my competences first as a student in one of France top engineer schools , then as PhD student with Jean Philippe Vert and Emmanuel Barillot and finally as a post doctorate scientist with Christina Leslie . My interests in computational biology led me to Institut Curie and then to Memorial Sloan Kettering Cancer Center . In both places , I designed and implemented new computational methods for the analysis of expression and copy number data . As a research scientist in the bioinformatics core at Memorial Sloan Kettering , I learned to analyze high throughput sequencing data in a clinical and in a research setting . I built upon these skills as I took on the role of Computational Research Leader at the Center for Hematologic Malignancies at Memorial Sloan Kettering Cancer Center . Under the supervision of Ross Levine , I developed and lead efforts to analyze RNA and DNA high throughput sequencing data . My work included both gene level and functional level analysis and strong collaborations with clinicians as well as with wet lab biologists . In 2017 , I joined Rockefeller University where , as the Vincent Meyer clinical scholar and an Instructor in Clinical Investigation , I will research the genetic factors causing susceptibilities to infectious diseases under the mentorship of Jean Laurent Casanova . Specialties : Research , computational biology , machine learning , cancer research , immunology , genomics , high throughput sequencing .. Technologies :",
"Director DMPK and Principal Scientist . . Director DMPK and Principal Scientist in R D Early REspiratory Immunology Senior DMPK Design Leader with more than 13 years of research experience in the Pharmaceutical industry transforming Hits into Drugs . Worked in more than 40 Drug Discovery and Early Development Projects from Early Drug Discovery up to Late Development and regulatory applications in multiple areas and targets by oral and inhaled route : ie . cardiovascular , metabolism , gastrointestinal , renal , respiratory , lung regeneration , inflammation antivirals and autoimmune . Responsible for the progression , selection and quality absorption , distribution , metabolism and excretion properties and the right pharmacokinetic profile in human of NCEs up to the Candidate CD stage and development compounds , setting up and executing the in vitro and in vivo DMPK strategy in projects including PK and PK PD , leading a team of ADME , Biotransformation and Modelling Simulation Scientists and advising senior management on potential risks of progression of compounds . Extensive experience as a manager , responsible for leading and motivating the DMPK PhysChem team to deliver robust and cost effective screening ADME data and ad hoc assays for LG campaigns and LO projects . Experience in outsourcing DMPK , including in vivo PK , studies to CROs , participation in Drug Discovery collaborations , due diligences and out and in licensing activities . I provide scientific and strategic leadership using strong matrix leadership capabilities and coach , mentor and help the long term development of scientists , while building organizational capability via leading strategic initiatives that contribute to the achievement of Business goals within approved budgets , plans and timelines . Specialities : DMPK , ADME Tox , formulation , biopharmaceutics , solubility , dissolution , absorption , distribution , metabolism , excretion , Drug Design , screening , PhysChem properties , Lead generation , Lead Optimisation , Drug metabolism and transporters , in vitro in vivo , Drug Interactions , PK PD , Human PK prediction , formulation , solid state , crystallisation , inhaled delivery , Protacs , Biologics , New Modalities , bRoF. Technologies :",
"Principal Scientist , Computational Science . . I am a computational biologist engaged in developing novel computational tools to extract biological knowledge from the tremendous amount of valuable public data . My research focuses on data integration , unsupervised feature extraction , and biological feature interpretation .. Technologies :",
"Postdoctoral Fellow . . I am a PhD level protein scientist with experience in purification , biochemical characterization , and structural determination by single particle cryo EM and X ray crystallography . My graduate and postdoctoral level research projects have encompassed systems involved in photosensation , aerobic respiration , secondary messenger signal transduction , and hormone metabolism of plant , bacterial , and mammalian origin . My current research interest lies in studying the interactions of proteins with partner proteins and small molecules to create their characteristic biochemical responses to environmental conditions or metabolic needs . I have experience with sample preparation in vitreous ice for single particle cryo EM as well as data collection and processing . As a crystallographer , I have background in vapor diffusion and lipidic cubic phase crystallization with and without robotic liquid handling systems . In pursuit of structural solutions , I have worked extensively on the chromatographic purification and characterization of recombinantly expressed proteins . I have worked with soluble and membrane bound proteins at all levels of structural biophysics from construct design and orthologue screening to intricate structural characterization . My strengths include design , implementation , evaluation , and troubleshooting of expression and purification protocols ; meticulous and detail oriented structural refinement ; protein structural functional analysis from multiple structures ; and scientific writing that emphasizes the logical connections from current work to past and future experiments . I seek opportunities to improve , exploit , and diversify my skills while finding answers to fundamentally important scientific questions .. Technologies : Xray;CryoEM",proteins;small molecules;characterization;interaction;structure
"Head of Informatics . . I 'm a data scientist and engineer with a background in computational biology and neuroscience . I thrive working with and building teams to tackle complicated problems and deliver valuable , elegant , and documented solutions .. Technologies :",
"Mathematician Postdoctoral Fellow . Plans and carries out mathematical modeling and computer programming work to study cardiac arrhythmia mechanisms , signaling pathways , and mechano chemo transduction . Promotes and advances projects that emphasize the application of mathematical theories to model problems in life sciences . Provides mathematical assistance to labs in statistics , data analysis , and data rendition . Additionally , creates tools using R Shiny or Python for image analysis e.g. , protein labeling , and correlation between channels . Participates in the design of lab experiments and in suggesting statistical methods suitable for data analysis . Works on modeling calcium dynamics in heart cells through the use of Finite Element Analysis FEA , and solver simulation software such as COMSOL Multiphysics and Matlab . Introduced and leads R Shiny software deployment for Trainees and non programmers to be used for the emph streamlined analysis of experimentally acquired data . Supervises and guides undergraduate researchers in fields such as pharmacology , bioengineering , mathematics , and computer science in learning about mathematical modeling through programming and critical thinking . . Experienced applied mathematician and statistician with a variety of versatile skills developed through years of research in mathematical modeling and simulations ; scientific computing ; and data analysis . Research interest include mathematical biology , pharmacology , pharmacodynamics , statistical inference , and general inverse problems . Scientific Expertise includes the following : Critical thinking , Ability to distill condensed information to a wider audience , Skillful at data analysis , data summary , and data rendition , Autonomy in leading research , Experienced in mentoring . Selected Technical Expertise : Matlab , R including Shiny , and Python for statistical and numerical computing , Parallel computing on HPC clusters , including MPI with C C and pbdr packages for R , Expert programmer in JavaScript JQuery Ajax , PHP , HTML CSS , MySQL SQLite for database management , Linux environments , especially Ubuntu and Debian . See the attached document for my detailed Resume .. Technologies :",
"Principal Bioinformatician . . A competent and motivated data analyst who has extensive experience of statistics and probability , as well as a software engineer with computer programming skills , . Contributing extensively to team work with people in different fields and always displays a willing and helpful manner when resolving problems . Working for more than five years as a biological data analyst , I am proficient in Perl , Matlab , R , Python , C and Java Programming , handling in various types of datasets . I am also familiar with website development and database maintenance by MySQL , HTML , CGI , CSS . Through my professional research on NGS data analysis , I have acquired considerable experience in designing statistical model , developing project workflow and manipulating high dimensionality data , giving reasonable solutions related to the practical problems as well . I specialize in identifying future trends , usage patterns and growth patterns through data mining and machine learning that assist to make good decisions . Specializing In a . Data Analysis : statistical modeling , data simulating , evaluating , proposing solutions b . Software Development : programming , algorithm design , application development c . Database Development : data collection , database development Profile Research Fellow in the University of Nottingham Doctor of Engineering in Bioinformatics from the University of Tokyo MEng BEng in Bio Medical Engineering from Southeast University Fluent in English and Mandarin . Technologies :",
"PHD Student . . PhD student at DTU Bioengineering , Department of Biomedicine and Biotechnology Working with protein structure of E3 ubiquitin ligase using cryo EM as a technique . Top 3 jobs and education : 1 Cand . scient in Biochemistry specialized within protein chemistry , University of Copenhagen March 2017 2 2 years of student relevant working experience from a research department for Diabetes and metabolism , Rigshospitalet 3 1 year working experience in quality control , Novo Nordisk Top 5 skills : 1 Approve analytical test results 2 Molecular cell biological techniques e.g. cell cultivation , immunoprecipitation , SDS PAGE , Western Blotting , Immunofluorescence microscopy 3 Independent project management 4 Constructive approach to problem solving 5 Strives for optimizing working procedures Attitude : Always ask why . Technologies : CryoEM",enzymes;molecular glues;structure
Principal Scientist Analytical Development Project Lead . . . Technologies :,
"Chief Scientific Officer and Board member JJP Biologics . . In my 25 years full of passion for the discovery and development of novel antibody therapeutics , led me to be involved in the trajectory of preclinical preparation and design of first into man studies of various novel antibody based medicine , of which ibalizumab has obtained market approval . I have been an inventor of 20 patent applications across different disease areas . currently focused on designing antibody based precision medicine accompanied by a relevant companion diagnostic CDx . Through my extensive academic collaborations , I have gained extensive experience in molecular and cellular immunology evidenced by my co authorship of over 320 publications in international scientific journals in the field of medical biotechnology . As the CSO at Polpharma Biologics Utrecht , I am responsible for our innovative antibody pipeline , which includes humanized antagonist anti CD89 and its CDx . Furthermore , I am responsible for the development of our high producing cell lines and CMC development . I have developed our CHOBC platform and discovered our novel SPOT and SLIM technologies . Moreover , I developed a modulation toolbox to optimize CQAs . To evaluate the biosimilars in vitro , a complete bio assay toolbox has been designed to study interaction on living cells . At Polpharma Biologics , we leverage our biological knowledge and platform expertise for other Biotech companies to successfully develop their drugs from idea to commercialization . biosimilarmedicine cdmoservices NBE CMCdevelopment academiccollaboration precisionmedicine companiondiagnostic Specialties : Preclinical development of recombinant novel and biosimilar antibodies . This includes generation and selection of novel antibody therapeutics , the generating high producing stable cell lines , CMC development , development of potency , analytical and immunogenicity assays , selection and development of CDx , design of POC studies in animals , design of regulatory toxicology package to support first into man studies .. Technologies :",biologics;characterization;developing
"Postdoctoral Researcher . . Experienced Doctoral Researcher with a demonstrated history of working in the biotechnology industry . Skilled in NMR spectroscopy of biomolecules proteins and nucleic acids and their complexes , Biophysical Techniques Isothermal Titration Calorimetry etc . , X Ray crystallography , Statistical Data Analysis , SDS PAGE , Molecular Biology and Biotechnology . Strong research professional with a 5 year Dual Degree Bachelor of Technology BTech Masters of Technology MTech focused in Biotechnology from Jaypee Institute of Information Technology , Noida . . Technologies : Xray;CryoEM;ITC;NMR",nucleic acids;proteins;interaction;structure
"Senior Application Engineer . As a field applications engineer in the Materials and Structural Analysis Division of Thermo Fisher Scientific , I provide world class technical support to our organization and our cus tomers : Our customers . My primary responsibility has been to our customers and their success . I have provided onsite and remote trainings for Tomography and Single Particle Cryo TEM on Thermo Fisher Scientific Autoloader Krios , Arctica , Glacios systems . This includes single particle sample preparation , suggestions for optimal data collection , and structure reconstruction . I also serve as the IT stakeholder in our team and provide customized solutions to integrate our microscopes into our customers internal networks . Our service organization . I have provided technical trainings to service engineers , service supervisors , and service managers in the AMER and APAC regions in advanced microscope alignments and data collections targeted towards our customers needs in single particle Cryo TEM and Tomography . This includes educating our field organization on the newest technologies in Cryo TEM released by our business unit , and providing support for system acceptance tests post installation . I have also developed a cloud data processing pipeline using Amazon Web Services AWS for use in the reconstruction of data for our Workflow Validation offering . Our sales organization . As a subject matter expert in Micro Electron Diffraction Mi croED I have given pre sales conferences in Shanghai , Campinas , and Otago to inform customers the benefits of MicroED for their studies and to promote Thermo Fisher offerings in MicroED world wide . I have also provided MicroED data collection and data processing trainings for our Hillsboro and Netherlands Nanoports . Our product marketing and development organization . As a subject matter expert in MicroED I have advised R D , product marketing , and product development for the development of Thermo Fisher s MicroED product offering . . Over a decade of experience in supervising and participating in gene to structure collaborations in academia and industry delivering client focused results with high attention to detail . Advanced expertise in structure refinement and structure solution via x ray diffraction and cryo EM MicroED , single particle analysis , and tomography of many difficult biological targets including structured RNA , soluble proteins , amyloid peptides , and membrane proteins . Extensive knowledge of biomolecular modeling of ligands to proteins and RNA . Also capable bench biochemist in the generation and purification of biological samples , stabilization of multi protein complexes , and preparation of samples for cryo EM and crystallography . Specialties : crystallography , RNA , structural biology , difficult structure solution , large macromolecular complexes , membrane protein structure , small angle scattering , cryo electron microscopy , protein purification .. Technologies : Xray;CryoEM",
"Principal Scientist . . A highly self motivated research scientist with a strong passion for drug discovery In depth knowledge of cancer biology , immuno oncology and epigenetics Lead of multiple preclinical drug development programs in oncology , immune oncology , inflammatory diseases and osteoarthritis Expertise in target discovery , validation , assay development , mechanism of action and PK PD studies Experience in managing scientists and overseeing CROs . Technologies :",small molecules
Research Assistant III Lab Manager . . Currently living in San Diego and working in the Lyumkis Lab purifying proteins for cryo EM and biochemical studies related to chromatin remodelers . B.S. in Biochemistry from Montana State University where I studied AAV2 lipososmal cleavage using mass spectrometry within the Bothner Lab .. Technologies : CryoEM,proteins;structure
"Principal Scientist Computational Biology . As a member of the Integrative Biology Group in Internal Medicine Research Unit , my current role includes : 1 . providing image various optical microscopy images including histology , tissue images , plate well based cellular image etc and statistical analysis for OMTC ; 2 . driving automated image analysis for medical image e.g. MRI image in a large scale for public human data sets e.g. UK BioBank ; 3 . Leading the computational analysis for rodent behavior assay development based on machine learning and computer vision techniques ; 4 . Practitioning of integrative multi omics data analysis especially focusing on the combination of genomic and image data analysis . . Over the past years , I have been developing , applying and validating image data processing pipelines and statistical analysis methods to large amount of biological and clinical data to investigate progression mechanisms of diseases and or evaluate drug effect etc . I have been delivering high quality quantitative analysis solutions for decision making in a timely manner . An experienced and results driven researcher on image processing , computer vision , machine learning and statistical modeling . 10 years of experience in applying image processing , machine learning and statistics modeling to a wide range of biomedical problems . A fast learner , systematic analyzer , independent problem solver , and team player with strong communication skills and 20 publications . Technical Skills Programming Languages : Python , R , MATLAB , C and SAS Machine learning tools : Scikit learn , Pytorch , Keras , Tensorflow .. Technologies :",
"Project Group Leader . Supervision of graduate students , Master students , technicians in projects related to human membrane proteins and their regulatory complexes . DFG Project : https : gepris.dfg.de gepris projekt 491930377 language en Conception and planning of collaborative projects within Germany and abroad . Acquisition of funding for independent research programs . . Protein scientist with a keen interest in combining structural biology and cell based assays to understand protein function . I have broad experience in recombinant production , structure determination and biochemical characterization of membrane proteins and their complexes . Currently developing cell based assays to enable activity screening of numerous membrane protein targets .. Technologies :",membrane proteins;characterization;structure
"Senior Scientist Antibody Engineering . Identification of neutralizing antibodies for infectious diseases . Tumor disassociation , isolation and expansion of tumor inducing lymphocytes TIL . scFv bacterial library construction using PBMCs from convalescent patients . Characterization of scFv VHH functional clones screened and recovered using proprietory nanoreactor platform . Reformatting of lead scFv VHH candidates into full length IgG and VHH Fc fusions , and their expression in the mammalian expression system . Protein A purification and characterization of lead candidates using ELISA , western blotting , neutralization assay , SPR Biacore . Single cell cloning optimization for memory B cells recovered using proprietory nanoreactor platform . Antibody functional assays on PDMS surface and microcapillary arrays in nanoscale . I am specialized in Cell and Molecular biology , with more than 10 years of experience in virology and infections diseases . I am committed to understanding how molecular biology and recombinant protein engineering can be utilized to improve currently available therapeutics . I thrive in a fast paced and dynamic team environment that challenges my capacity for problem solving and troubleshooting . I have extensive experience in the design of antibodies and antibody fusions , and protein expression , purification and characterization ; a self motivated researcher who knows how to analyze and interpret data proficiently and a supportive team member who managed multiple projects in parallel and tight deadlines . Specialities Mammalian cell culture , cell based assays , in vivo models Antibody protein engineering Antibody fragments such as nanobody VHH single domain antibodies , scFv and monoclonal antibodies , molecular cloning , PCR qPCR Protein expression in yeast Pichia pastoris , plants Nicotiana benthamiana , bacteria E. coli and mammalian cells Protein purification AKTA explorer and biochemical biophysical characterization ELISA , western blotting , pharmacokinetics Mass spectrometry . Technologies : SPR",antibodies;characterization;engineering;interaction
"AV TechBio Fellow . ARTIS Ventures is a leading early stage venture capital firm in San Francisco , pioneering investments at the intersection of life sciences and computer sciences what we call TechBio . ARTIS invests at the convergence of these two industry trends . Investment focus areas include AI Drug Discovery , Synthetic Biology , Gene Editing , Digital Health , and more . Cooking something ground breaking HMU . Join us and let 's build more iconic companies that matter Check out our team and portfolio companies , incl . Outpace Bio , Locus Biosciences , Inc. , Excision BioTherapeutics , Freenome , Stemcentrx , Inc. more , at https : www.av.co people . I immigrated from Vietnam to the US at 15 . Despite having to learn English from scratch , I became the first in my family to attend college , thanks to scholarships mentors through orgs , incl . the Bill Melinda Gates , Dell , Greenhouse Scholars , National Institutes of Health , National Association for the Education of Homeless Children and Youth Following my graduation from Duke University in 2016 where I conducted HIV vaccine research at the Duke Human Vaccine Institute , I joined the US NIH Vaccine Research Center as a UGSP fellow to work on HIV cure In 2018 , I moved to Europe to pursue an Erasmus MSc degree in Vaccinology on full academic scholarship by the LIVE program , rotating through Spain , Belgium France . Meanwhile , I worked remotely as a research manager for an international research network in public health in Hanoi , Vietnam Following my internship at GSK Vaccines , I received 3 full academic PhD scholarships from Oxford . As a DPhil student , I apply high dimensional computational experimental tools to discover human CD8 T cells in lymphoid tissues . Manipulating the immune system through immune cells has applications in immunotherapy vaccine R D against viruses , cancers , autoimmune neurodegenerative diseases Building teams with good people to : Develop a cell based immuno modulatory vaccine to prevent multiple ageing related neurodegenerative diseases at once Invent ML app to organize knowledge connect people to the right team and resources to discover make their dream come true Life goal : Building a Centre of Learning to provide high impact , hands on skill training traditional schools do not teach to children and youths in under served communities The Centre will be built inside a community based flower garden and staffed by retired professionals and teachers . Learning how to use accumulated knowledge to change society The Signal and the Noise by Nate Silver They never decide it s too hard or not worth the effort . Babies don t worry about making mistakes or humiliating themselves . They walk , they fall , they get up . They just barge forward . Mindset by Carol Dweck they would rather back the individual than the solution ... that the right solution may never get airborne if it it is driven by the wrong person . But the right person will find the right solution even if that has n't yet happened . And they want to work with someone they believe in . Life 's a Pitch by Stephen Bayley Roger Mavity Twitter QNNDuke TikTok nhatquang73 . Technologies :",
"Director , Project Biology . I provide project leadership to small molecule drug discovery programmes , working with collaborators and or project teams to set overall strategic objectives including target candidate profiles and am responsible for the delivery of lead and candidate milestones through to pre clinical development . By providing leadership to multi disciplinary teams , I advance programs from the partnered and internal pipeline to deliver clinical candidates . Other key responsibilities include : Lead the biology aspects specifically , ensuring relevant and robust data is generated to drive discovery forward Provide effective coordination of functions , ensuring appropriate resourcing and timing of activities to maximise the impact of the project team . Development of successful internal and external relationships with partners , academic leaders and contract research organisations CROs . Implement drug discovery cascades , define relevant assay systems and endpoints , working with internal biology teams and external partners . . I have 10 years of experience working as project leader , team leader and subject matter expert in pharmaceutical industry and academia . I combine broad scientific expertise in advanced imaging , AI and high content data analysis , advanced cellular models , and different drug modalities small molecules , PROTAC , ASO , antibodies . I bring extensive leadership experience working on oncology , cardiovascular , metabolic and kidney projects , as well as previously on infectious diseases . I have strong analytical and communication skills , can manage multiple projects at a time and I work well independently . However , I thrive most in cross functional teams working together with others . In my current position I provide biology project leadership to small molecule drug discovery programmes , working with collaborators and or multi disciplinary project teams to set overall strategic objectives including target candidate profiles . I am responsible for the delivery of lead and candidate milestones from the partnered and internal pipeline to deliver clinical candidates . Email me at Mullers . Erik gmail.com Key Achievements : Progression of drug targets towards the clinic Leading a team of 8 scientists PhD in Virology and Cell Biology Authored 20 publications Supervised 15 Postdocs PhD candidates undergraduates Developed several novel assays Led international collaborations and conferences Core Skills : Project leadership Team leadership Drug development Molecular biology , cell biology Data analysis Advanced cellular imaging Assay development Supervision Scientific communication speaking , presenting , publishing Personal Qualities : Strong communication skills Excellent organisation and analytical skills Detail oriented Committed team leader Quick learner . Technologies :",molecular glues;small molecules;developing;screening
"Associate Principal Scientist . . Cryo electron microscopy expert enabling small molecule discovery for difficult targets . Proven track record of high impact structure determination in academic and pharmaceutical settings . Proven funding record for academic and social outreach projects . Strong analytical skills with graduate training in engineering , mathematics , medical sciences , and biochemistry . Experience in assay , product , and business development . Demonstrated commitment to diversity and inclusion .. Technologies : CryoEM",proteins;small molecules;structure
Senior Bioinformatics Scientist . . . Technologies :,
"Senior Director of Target and Drug Discovery . . I received my PhD at the Friedrich Miescher Institute of the Novartis Research Foundation in Basel , working in the field of immunology . My specific focus was transcriptional regulation in B cells . I then joined the Experimental Hematology group at the University Hospital Basel working on Myeloproliferative Neoplasms MPN . During that time , our group discovered a highly recurrent mutation in the kinase JAK2 that has led to an approved therapeutic . My work included generation of a transgenic mouse model for JAK2 V617F driven disease that yielded valuable insights into the pathogenesis of MPN . In 2008 I took on a position as lab head at the Novartis Insitutes for BioMedical Research NIBR in the disease area Oncology in Basel . My main responsibility to date is the co leadership of large drug discovery teams . In addition , I contribute to the discovery and validation of novel oncology targets . In the meantime , my first project has reached the stage of clinical development , giving me the opportunity to contribute to translational research . Finally , I mentor postdocs and master students and thereby have the opportunity to also pursue research that leads to publications .. Technologies :",small molecules;screening
"Analytical Scientist . . Specialties : Protein Chemistry Analytical Chemistry Biophysical Characterisation of Proteins and Peptides : Self association , Aggregation and Fibrillation Size Exclusion Chromatography SEC Field Flow Fractionation FFF Static Light Scattering SLS Multi Angle Light Scattering MALS Dynamic Light Scattering DLS ThT Assays Structure in Solution and Crystals : Circular Dichroism CD Small Angle X ray Scattering SAXS X ray Crystallography . Technologies : Xray;SLS DLS;CD",peptides;proteins;characterization;stability;structure
"Scientific Assistant . Structure determination of membrane proteins by single particle cryo EM . . I have been in the cryo EM field for over 14 years and have worked on everything from tiny RNA molecules back in the day , before there were direct electron detectors and motion correction to large protein assemblies like the nuclear pore complex . In the last three years , I have been in the membrane protein field , with focus on several of the liver membrane transporters . I love challenging projects and particularly those that drive technology development . Looking for job opportunities that will allow me to follow my own crazy ideas and collaborate with others on exciting new projects .. Technologies : CryoEM",membrane proteins;structure
"Associate Principal Scientist . . A dynamic and motivated industry researcher with demonstrated expertise in systems biology , infectious disease , oncology , and project management , committed to the development of new medicines . A strong analytical thinker and a creative problem solver with broad experience in scientific data analysis and a deep understanding of biological principles and computational techniques . A versatile and resourceful professional that thrives in interdisciplinary and collaborative team environments . A quick and fearless learner , an effective big picture thinker , an effectual organizer , and an excellent presenter . . Technologies :",
"Computational Chemist . . A computational chemist with Ph.D. in computational chemistry , and nine years of drug discovery experience in pharmaceutical industry , with expertise in every stage of small molecule drug discovery , including target assessment , HTS triage , ligand based and structural based virtual screening , library design , scaffold hopping , SAR analysis , cheminfomatics , protein ligand interaction free energy calculation , molecular dynamics , etc .. Technologies :",
"Scientist . . My intellectual curiosity and passion for asking questions led me to pursue my Ph.D. in Biochemistry and Molecular Biophysics . I have worked on several relevant projects that provided me with the skill sets I need to be an effective postdoc . Within one of my projects , I successfully expressed human complement protein factor H fH by HEK 293 and freestyle F 293 cells , refolded and purified it with size exclusion and affinity columns by tangential flow filtration and GE Akta fast protein liquid chromatography . To explore the protein interactions , I used Biacore T200 surface plasmon resonance to detect the minimal binding partner within fH and Beta C protein , a Group B Streptococcal surface protein . I also screened and optimized the Beta C protein crystals by both Crystal Phoenix protein crystallization robot and manually hangover drops , successfully shoot crystals through Argonne National Lab , and built crystal structure models with a resolution of 2.36 by Phenix and Pymol . My passion for teaching has provided me with a unique skill set that I believe will be critical for a successful career . During my two and a half years teaching assistantship as a Ph.D. and master , my communication skills strengthened as I challenged myself to understand and respond to students questions while they tackled complex biological concepts . I also mentored new graduate students and let them fit quicker and feel more comfortable in our lab . The analytical and communication skills I have honed throughout my education will provide a strong foundation as I devote myself to the life sciences . I am specifically interested in protein protein interactions and structural analysis due to its unique approach to understand proteins and think the combination of crystallography and Cryo EM will be the trend in the protein structural field . Till now , I have ten peer reviewed publications , including five first author papers , and one of them was on the cover and top reads of the issue .. Technologies : CryoEM;SPR",proteins;interaction;structure
"Vaccinator . . Driven cell biologist with a passion for applied biotechnology and cell signaling . Aspire to solve real life problems within human health and sustainability by hands on lab work . 8 months of experience in yeast GPCR biosensor research development expertise : cell based biosensors , R D , biotechnology , cell signaling , molecular biology , microbiology Techniques : bacterial , yeast and mammalian cell cultivation , USER cloning , transformation and protein expression in mammalian and yeast cell lines , cell induction protocols , fluorescence microscopy , confocal laser scanning microscopy , GC MS analysis , sterol extraction Contact : 45 24836844 Lukasronildhansen outlook.dk . Technologies :",
". . I am an experienced Postdoctoral Researcher with a demonstrated history of working in the field of life sciences . I consider myself a biochemist who uses structural biology tools to examine and analyse biological problems . Having used X ray crystallography for several years to study structures of proteins involved in metabolic pathways and fertilization protein complexes , I am currently focussing on investigating membrane transporters using single particle cryoEM . I am skilled in recombinant DNA technology , protein expression in various systems and protein purification using different methods to get crystallization quality or cryoEM suitable samples . . Technologies : Xray",membrane proteins;structure
"Graduate Research Fellow . . An enthusiastic learner and hoping to do some good for humanity . Graduated from IIT Kanpur with a Bachelor in CSE . My academic and research interests are primarily Computational Biology and Bioinformatics , Machine Learning , Data Science . Currently pursuing PhD at USC .. Technologies :",
"Development Scientist . Coordination of CMC API process chemistry development . . Highly trained synthetic chemist with experience in both academia and industry . Research background spans reaction methodology , chemical biology , organometallic chemistry and chemical education . Strong verbal and written communicator with a proven track record of both leading projects and working within large , multidisciplinary teams . Inquisitive , creative thinker with an independent mindset and a passion for taking on new challenges and making a difference in the world through science . Currently a Development Scientist with Novo Nordisk working on API chemical process development for clinical trials .. Technologies : Xray;MST",
Research Assistant . Phage display library . Antibody screening . Bio panning assay . Functional assay . . Technologies :,antibodies;interaction;screening
"Bioinformatics Scientist . Performing statistical and machine learning modeling for precision epigenomic medicine . . Data scientist experienced in analysis of Next Generation Sequencing cancer genomics . Interested in applied computational models , interdisciplinary projects , algorithmic thinking , mastering machine learning and statistical analysis . Proficient knowledge in R and Python .. Technologies :",
Computational Scientist . . . Technologies :,
PhD Student at Max Planck Institute . Structural biochemistry Cryo EM Muscle cells . . Technologies : CryoEM,proteins;structure
"Associate Computational Biologist . Worked closely with my PI to design secure , interactive , federated analysis to ensure genetic privacy . Used applied cryptographic techniques to implement pipeline for secure genomic analysis in Golang . Processed large genetic databases and designed experiments to evaluate accuracy and efficiency of the aforementioned pipeline . . I want to leverage my background in biology and computer science to build tools to better inform the way we approach healthcare .. Technologies :",
"Graduate Researcher . Neuroimaging EEG fNIRS researcher and machine learning engineer . Built wearable brain computer interface by designing novel pipelines as well as implementing novel algorithms from journals for regression and classification . Conceptualized ideas . Designed experiments . Built and organized database . Developed stimulus presentation and UI . Built hardware using 3D printer and machinery tools . Developed data acquisition . Developed and validated pipelines for signal processing , regression , classification , data visualization and statistical tests . Codes optimized with parallelization and high performance computing . Replicated and validated pipelines for real time hybrid EEG fNIRS brain computer interface for detection of both overt and imaginary finger tapping cortical activity . Contributed to Homer3 , an open source software for fNIRS data analysis . Currently writing 2 papers for publication for high impact journals . Teaching assistant for electro mechanical laboratory based course . Used oscilloscopes , function generators , digital multimeter , breadboard circuit , and op amps for different sensors for strain , temperature , pressure , wind turbines , etc . Debugged faulty breadboards and burnt capacitors . Supervised labs and graded lab reports . average students ' rating : 4.43 5 Teaching assistant for probability statistics course . Led discussion sections and graded homework and exams . average students ' rating : 4.23 5 Supervised undergraduate and graduate research assistants . Modeled multi cast device to device wireless communication using Palm Distribution for Spatial Poisson Point Process for Wireless Communication class . Modeled RNA probe as detector of antibiotic resistance with partition function using Boltzmann weight for Computational Biology class . Improved design in Arduino powered alternative assistive communication . Organizer of BU Hearing Research Center weekly seminars . Invited researchers , planned itinerary and logistics for seminars . . Researcher and engineer with a strong background in signal processing , machine learning and software hardware programming . Ph.D. candidate anticipating to graduate by the end of summer or early fall 2022 .. Technologies :",
"Staff Research Scientist Manager . . Machine learning researcher , tech lead and manager . Passionate about creating and driving theory based machine learning projects and bringing them to production . Strives to work in a fast paced , creative and collaborative environment on hard open ended problems with real world impact .. Technologies :",
"MRC Senior Fellow . . My research focuses on understanding how molecular biology shapes brain function in healthy and diseased brains . In the healthy brain I aim at answering questions such as Which genes are responsible for variations in neural activity in the resting brain whereas in the diseased brain I want to understand which processes are causing severe malfunctions leading to neuropsychiatric and neurodegenerative disorders such as Major Depressive Disorder and Alzheimer s disease . My goal is to understand the molecular biology behind these disorders ; down the road such an understanding may result in new drug candidates . Furthermore , I am interested in developing disease biomarkers that assist in early detection of the disorder and in personalizing the treatment . Thus , my research interests are centered on topics in neuroimaging , molecular genetics , and machine learning and their combinations .. Technologies :",
"Assistant professor Forskarassistent . UCMR ; Bacterial Cytoskeleton Structure , Intermediate Filament Structure and Assembly Studies by Cryo Electron Microscopy . . Technologies : CryoEM",proteins;structure
"Lecturer in Translational Cancer Bioinformatics . . Professional member , British Computer Society ; STEM Ambassador ; TechWomen100 Award 2018 ; Women in Tech Award Data Scientist 2018 ; BCSNI IT Professional of the Year 2019 . Background in mathematics and computing . Currently working in Bioinformatics biostatistics within stratified medicine . Interested in : data mining , unsupervised supervised learning , prognostic predictive biomarkers . Course director : MSc Bioinformatics and Computational Genomics .. Technologies :",
"Scientist I , Computational Biology . Run analysis pipelines on data generated from novel CRISPR Cas9 assays . Evaluate , integrate , and extend existing bioinformatics and next generation sequencing NGS tools as well as create new tools and algorithms for analyzing genomic data . Work with preclinical teams to deliver insights and recommendations to decision makers for novel CRISPR based gene editing therapies . Extend pipelines with functions that leverage novel molecular biology and troubleshoot issues , implement test cases , and fix bugs . Convert research prototype scripts into robust scientific software optimized for performance , scalability , and adherence to coding best practices . . Senior Bioinformatics Engineer with 5 years of experience working with next generation sequencing NGS data sets to perform tasks such as whole genome sequencing , gene expression analysis , targeted deep sequencing , genome annotation , and others . I build novel pipelines and codebases for processing genomic data that is used to create cell based gene therapies , including chimeric antigen receptor CAR T cell immunotherapies . Much of my current research centers on predicting , evaluating , and mitigating CRISPR Cas9 mediated off target editing events . I have a B.S. in computer science and strong interests in biology and programming , with a particular focus on genomics . I thoroughly enjoy the processing , visualization , and analysis of complex data sets , especially as they relate to human health and disease .. Technologies :",
"Ph.D. Candidate . . I am a First Generation College Student and Scientist in my family . My work ethic stems from watching my famoly work hard for a place in this country . Many of my science teachers and professors of the past helped shaped me and my passion to do quality research . I am looking for a position that will utilize and challenge my years of experience in protein purification , solutions biophysics , and structural biology . The nature of the projects I led can be described in one word , optimization . Optimizing expression and purification protocols for high yield and purity without sacrificing protein activity . Optimizing buffer , protein labeling , and experimental setup strategies for characterizing my proteins of interest by obtaining reproducible and clean measurments on multiple instruments such as : ITC , FP , BLI , DSF , AUC , DLS , and MP . Optimizing crystal growth conditions and cryo EM grid sample conditions for many fruitful data collections . The skills I have gained in the past 8 years was not done alone . I am a quick learner who enjoys working in highly collaborative environment . I work well underpressure in both my science and communication . Wish me luck in finding a good fit .. Technologies : CryoEM;ITC;SLS DLS;BLI;AUC;DSF;FP",proteins;characterization;expression;interaction;structure
"Analytical Chemist . GMP based works Stability study Drug release . Analytical pharmaceutical research and development pharmacist with experience in drug registration and worked as a Common Technical Dossier Writer . I also served as an Influenza Vaccine Project coordinator as well as a Monoclonal Antibody Research Assistant . I did my master s at the University of Tartu , Estonia , and Uppsala University , Sweden , and completed my master s Research project which was to Validate and do targeted metabolomic profiling using a Biocrates MxP Quant 500 Kit in plasma and matching cerebrospinal fluid samples in patients with the neurological disease Myalgic Encephalomyelitis . Therefore , I have a solid experience in LC MS from this thesis . My latest strong career highlight is Analytical chemist in the stability and release testing where I keep on developing GMP work and review , deviation management . I succeeded in developing an analytical method in tablet medicine for drug registration , including developing the Assay , Identifying Impurities , Dissolution method and ensuring that the Stability indication method functioned as well as transforming all the data into the registration form . I also oversaw the Bioequivalent Study and the Biowaiver study of tablet based medicine . Therefore , I have a solid knowledge of international medicinal guidance , such as the International Conference on Harmonization ICH Q2 R1 , Q1A R2 , Pharmacopoeias including USP , BP , and Ph . Eur . During my final year internship at Pharmacy School in Thailand , I developed a serum free medium plate form for selecting high producer mammalian cells instead of a serum containing medium to decrease the time consumed in for host cell line development , which is one of the upstream process developments . During my undergraduate studies , I also maintained several part time jobs in pharmacy stores where I learned to interact with customers , handle sales as well as keep an eye on stock control . I am looking for professional work in which I could improve my talent in analytical chemistry , drug development , quality assurance , and regulations . I am the one who is willing to learn new knowledge .. Technologies :",
Principal Scientist . . . Technologies :,
"Computational Biologist . I apply computational biology and informatics to integrate complex data types , supporting key decision making across GSK 's R D pipeline at all phases . I work closely with multi disciplinary teams of biologists , chemists , and clinical scientists to develop and implement novel computational approaches for the analysis of large , project specific genetic and genomics data relevant to multiple disease areas . The computational and transcriptomics analyses I perform directly impact target discovery and drug discovery pipeline , with the goal of ultimately helping patients with unmet medical needs . . I am a computational biologist with experience in developing and implementing novel computational approaches for the analysis of large scale genomics data . I currently enable target discovery and drug discovery pipeline decisions at GlaxoSmithKline . I also have deep experience in computational biophysics , including elucidating the dynamic effects of disease associated mutations , post translational modifications , and evolutionary changes on the function of macromolecules . . Technologies :",
"Doctoral Candidate . Supervised by Dr Sonja Lorenz Investigating mechanisms of HECT E3 ubiquitin ligases using cryo EM , crystallography , and biochemistry . . . Technologies : CryoEM",enzymes;molecular glues;interaction;structure
"Senior Research Officer . . Specialties : Transmission Electron Microscopy , Cryo Electron Tomography , . Technologies : CryoEM",
"Senior Scientist . . A protein biophysicist and biochemist with over 10 years of international experience in the study of protein interactions with HDX MS . Expertise in developing MS based methodologies for the characterization of membrane protein complexes , PPIs , small molecule protein interactions and fragment screening for drug discovery . Experienced with the operation and maintenance of LC MS systems . Team work , analytical and problem solving skills cultivated across over 10 interdisciplinary projects , through close collaboration with structural and computational biologists , cell biologists and medicinal chemists . Enthusiastic and creative colleague who has a drive to seek innovative solutions to solve challenging scientific problems . . Technologies :",membrane proteins;proteins;small molecules;interaction;screening
"Bioinformatics Scientist . Using statistics and computer to power biotechnology and healthcare . 1 . Developing bioinformatics pipelines to analyze omics data based on AWS and nextflow . 2 . Automating analytical report generation based on Rmarkdown . 3 . Digesting cellular heterogeneity in biological samples based on epigenetic and RNA markers . . For continuously improving human wellness , I have been devoted into the field of biotechnology for more than 15 years , aiming to develop efficient and affordable healthcare products . To this end , my research has focused on gene regulation the core process of tissue organ development and the basis of disease progression . With my expertise in bioinformatics , statistics , and evolutionary biology , I am on the way .. Technologies :",
"Stem cell laboratory . . I m a highly enthusiastic and ambitious biochemist , specialized in molecular immunology especially B cell T cell interaction and protein analytics PROTACS in cancer cells . I have a progressive and open mind and are willing to explore new challenges and opportunities to excel further . Currently , I m screening and characterizing blood cancer patients and stem cell donors . . Technologies :",molecular glues;developing;interaction
"Bioinformatics Lead . . Data scientist deeply rooted within bioinformatics and structural biology . Thrilled by new , daring projects on the verge of impossibility . Interested in novel , multidisciplinary , challenging projects . Soft spot for translational science and intellectual property issues . Specialities : data science , machine learning , deep learning , data exploration , computational immunology , drug discovery , protein structure prediction , membrane proteins , bioinformatics , structural biology . In the past : data networks , network security , general IT infrastructure and IT management . . Technologies :",
"Principal Scientist , New Antibody Product Research . Working as Principal Scientist at Genmab , a biotechnology company that creates and develops differentiated human antibody therapeutics for the treatment of cancer . I have extensive experience in the discovery and characterization of therapeutic monoclonal antibodies and am also involved in antibody innovation and the development of novel antibody formats . . My main areas of interest include adaptive immunology , oncology and antibody biology and engineering . . I work as Principal Scientist in the Antibody Science Department at Genmab , a biotechnology company that creates and develops differentiated human antibody therapeutics for the treatment of cancer . I have extensive experience in the discovery and characterization of therapeutic monoclonal antibodies and am also involved in antibody innovation and the development of novel antibody formats . . My main areas of interest include adaptive immunology , oncology and antibody biology and engineering . . . Technologies :",antibodies;characterization;developing;engineering
"Associate Principal Scientist . Computational analysis of fungal genomes to identify novel therapeutics . I 'm an innovative scientist with over 12 years of experience in using both experimental and computational techniques to tackle challenging biological problems of global importance . Specialties Systems biology , metabolic modeling , metabolic engineering , transcriptional regulatory network inference and analysis , computational biology , strain development , molecular biology , next generation sequencing . Current research focus Understanding how cells process the numerous signals they encounter in nature into meaningful responses requires the acquisition of in depth knowledge of their regulatory and metabolic features . One approach to facilitating this process of knowledge acquisition involves the use of predictive models that integrate data from different types of biological networks . The application of such approaches can very powerful and have broad and far reaching implications . My current research is focused on the use of computational and experimental approaches to study different algal species with the aim of improving their yields of biomass and triacylglycerols oils that could potentially be used in manufacture of renewable fuels .. Technologies :",
PHD Student . Cryo EM Ubiquitin E3 ligases . . Technologies : CryoEM,molecular glues;proteins;structure
"Laboratory Head . Laboratory Head Exploratory Analytical Development CMC developability assessment of novel drug substances and respective formulations oral and parenteral , across indications at the interface between research and development Physicochemical characterization of drug substances and drug products stability , solubility , dissolution Part of interdisciplinary project teams with stakeholders from research and development functions e.g. medicinal chemistry , pharmacology , toxicology , DMPK and formulation development . I am an organic chemist with 4 years of R D experience in the pharmaceutical industry , and currently part of a highly skilled and passionate team shaping the way of novel drug candidates to early stage clinical development . Pursuing my passion for life sciences , I expanded my strong background in small molecule analytics PhD at University of Cologne , Germany by computational methods Fulbright fellow at University of Notre Dame , US and techniques in synthetic and structural biology PostDoc at Imperial College London , UK .. Technologies :",small molecules;developing;formulation
"Associate Principal Scientist . . Medicinal chemist working to find novel treatments for patient suffering from cardiovascular , metabolic and renal diseases . Currently working as a chemistry lead with a team of internal and CRO based chemists on the development and optimization of selective protein degraders , using the PROTAC MoA. As part of the cross disciplinary project core team , I am specifically responsible for PROTAC design , synthesis and profiling , chemistry strategy , and milestone deliveries , but also support and interact closely with adjacent disciplines . Experience from both small molecule and PROTAC projects , in early and later phase of preclinical development , and a strong believer in technology driven medicinal chemistry , including the strategic application of modern synthesis , high throughput experimentation and automation , and artificial intelligence augmented drug design .. Technologies :",molecular glues;small molecules;developing;screening
"Principal Scientist . . Expertise in membrane protein X ray crystallography : screening and optimizing crystallization conditions , data collection , de novo phasing , model building , and refinement Extensive experience in biochemical and biophysical characterization of membrane proteins Interest in protein structure and function , enzymology , and drug discovery and design . Technologies : Xray",membrane proteins;characterization;structure
"Senior Research Scientist . . SKILLS AT A GLANCE Assay Development and HTP screening : Using fluorescent and colorimetric assays to detect metabolites of interest in vitro with purified enzymes or cell lysates , and in vivo screening of S. cerevisiae production strains expressing enzyme variants . Protein Engineering : To increase activity , specificity and stability , and decreasing product inhibition using rational Based on Literature , MSA , Homology modelling etc . and random Homology model guided site saturation mutagenesis engineering strategies . Protein Characterization : Purification by FPLC kta , Microcalorimetry TAM , ITC and DSC , Analysis of binding affinity and physicochemical properties thermostability and reaction optimum . Laboratory Automation : Of enzymatic assays , cloning protocols , strain screening , fermentation and AC sample handling using Hamilton STAR and Zymark Rapidplate liquid handlers . Cloning and Metabolic Engineering of S. cerevisiae , B. subtilis and E. coli with a Biobrick platform USER cloning , and Crispr Cas9 technologies .. Technologies : ITC;DSC",enzymes;proteins;small molecules;characterization;engineering;screening;stability
"Principal Scientist Discovery Project Team Lead . . Biochemistry and Biophysics . drug targets . membrane protein expression and purification . biochemical and biophysical characterization . FBLD . SPR Biacore . Drug discovery . Project team member . fragments . binding assays . NMR . MST . MICROSCALE THERMOPHORESIS . SAW . SURFACE ACOUSTIC WAVE . Residence time . . selected publications . . Gr dler U , Schwarz D , Dresing V , Musil D , Bomke J , Frech M , Greiner H , J kel S , Rysiok T , M ller Pompalla D , Wegener A. Structural and biophysical characterization of the Syk activation switch . J Mol Biol . 2013 . . Stefer S , Reitz S , Wang F , Wild K , Pang YY , Schwarz D , Bomke J , Hein C , L hr F , Bernhard F , Denic V , D tsch V , Sinning I. Structural Basis for Tail Anchored Membrane Protein Biogenesis by the Get3 Receptor Complex . Science . 2011 . . Schwarz D , Daley D , Beckhaus T , D tsch V , Bernhard F. Cell free expression profiling of E. coli inner membrane proteins . Proteomics . 2010 . . Schwarz D , D tsch V , Bernhard F. Production of membrane proteins using cell free expression systems . Proteomics . 2008 . . Keller T , Schwarz D , Bernhard F , D tsch V , Hunte C , Gorboulev V , Koepsell H. Cell free expression and functional reconstitution of eukaryotic drug transporters . Biochemistry . 2008 . . Schwarz D , Junge F , Durst F , Fr lich N , Schneider B , Reckel S , Sobhanifar S , D tsch V , Bernhard F. Preparative scale expression of membrane proteins in Escherichia coli based continuous exchange cell free systems . Nat Protoc . 2007 . . Schwarz D , Klammt C , Koglin A , L hr F , Schneider B , D tsch V , Bernhard F. Preparative scale cell free expression systems : new tools for the large scale preparation of integral membrane proteins for functional and structural studies . Methods . 2007 . . Klammt C , Schwarz D , Fendler K , Haase W , D tsch V , Bernhard F. Evaluation of detergents for the soluble expression of alpha helical and beta barrel type integral membrane proteins by a preparative scale individual cell free expression system . FEBS J. 2005 contributed equally . Technologies : SPR;MST;NMR",membrane proteins;proteins;characterization;expression;interaction;screening
"Associate Computational Biologist . . Bioinformatics professional with a proclivity for life science and programming . I am keen to work in a fulfilling environment that constantly challenges me , helps me learn and grow both personally and professionally and , allows me to realize my full potential through my tenacity and diligence . I enjoy meeting new people and discovering different perspectives and have an unquenchable desire for frenzied knowledge .. Technologies :",
"Research Scientist Biopolymers . . I am a Post Doctoral Research Scientist having an experience of more than 9 years in the field performing diverse functions of Research and Development , Teaching and Lab Administration . I am currently spearheading with Zentrum f r Molekulare Biologie in der Heidelberg Universit t ZMBH as Post Doctoral Scientist , accountable for studying the functional aspects of the heat shock protein 90 Hsp90 using a variety of Biophysical techniques . I am an academically astute professional , holding Ph.D. and M.Phil . degrees in Biophysical Chemistry from Cambridge University , United Kingdom . I am proficient at interfacing with different teams and work in team spirit and integrated the twin fundamentals of research and development for translating the conceptualizations into solutions . I hold experience in handling entire spectrum of research and development activities include analyzing data , processing and publishing results , creating new research proposals , and interacting with multidisciplinary teams . Through innovative approaches , technical know how and sound exposure gained via handling research and development projects , I have gained the ability to implement research methodology to projects involving diverse experimental and analytical techniques , interpreting the research results and summarizing the research findings for presentation and or publication . During my past experience I served in the capacity of Laboratory Teacher and Research Associate . I possess keen teaching and development acumen and the ability to deliver lectures on Chemistry and Biophysical Chemistry topics . I am also skilled at handling Chemistry lab equipments . Keen to utilize my technical and analytical skills to support the research and development projects . To discuss my experiences , feel free to connect with me on LinkedIn . Technologies :",proteins;characterization
"Lecturer . . I am currently a lecturer and tutor in computational mathematics at Goldsmiths University . I have had research appointments at The Alan Turing Institute , PHE , Imperial College London , University of Surrey , Max Planck Institute for Complex Systems , Institute of Theoretical Physics in Amsterdam UvA . My interdisciplinary research bridges Biology , the Physical Sciences , Social Sciences and Computer Science . I have worked and published in several fields of research , including theoretical physics , biological physics , systems biology , epidemiology and Machine Learning applied to social sciences . My work has been highlighted for relevance by the American Physical Society and has accrued more than 125 K accesses on nature.com .. Technologies :",
"Head of Medicinal Chemlistry . . Longstanding experience of multidisciplinary project leadership . Project Leader in the fields of Neurology CNS , Route Scouting and Process Chemistry 7 projects managed . Multiple launches of new projects 4 new projects successful launch for 10 proposed . Project leadership at various stages of Drug Discovery , from Hit ID until Early Development , including back up programs 7 projects managed so far , Phase I and Phase II compound identification . Lead of experienced Synthetic Medicinal Chemists up to 5 PhD s and graduates . Operational experience of department leadership . Head of External Chemistry , New Medicines , Medicinal Chemistry up to 74 external chemists on board . Member of Chemistry Department leadership team . Global Operation through Optimization of the UCB Compound Library , 4 year project aimed at increasing the size , quality and diversity of UCB proprietary compound library . Specific scientific areas of expertise . Hit ID and Lead Optimization . Experienced Medicinal Chemist with significant contributions as Lead Chemist into a variety of preclinical programs hit identification , hit to lead , lead optimization and candidates selection phases . Expert knowledge of GPCR s , enzymes , ion channels transporters drug discovery . Responsible for the chemical strategies and Hit ID . Strong internal and external network . Chemistry problem solver . Technologies :",small molecules;developing
"Senior Researcher . Project : Combining in silico screening , structural investigation , lipid identification and assay development to unravel the specificity of Glucose Transporters . Project : Structural basis for the delivery of activated sialic acid into Golgi for sialyation . . Structural biologist combining expertise in Biochemistry cloning , expression , purification , stabilization and engineering of soluble or membrane proteins , characterization and assay development , Biophysics Protein crystallography , ITC , SPR , MST ... and Bioinformatics sequences analysis , de novo and homology modeling , molecular dynamic simulation , small molecule protein protein protein docking . I have a strong interest in linking protein dynamic with function and to apply my discoveries into drug design . With a team orientated mindset , I value collaboration , exchange and mentoring as central to catalyze creativity , motivation , and efficiency . Curiosity driven , I strongly believe that method development is essential to push the limit of discovery and therefore I always try to apply or create new approaches or technologies in order to reach my goals .. Technologies : Xray;ITC;SPR;MST",membrane proteins;characterization;engineering;interaction;stability;structure
"Director , Bioinformatics . Managing a team of bioinformaticians and data scientists to develop solutions that enable in silico novel antibody and drug discovery . . Managing a team of bioinformaticians and data scientists to develop solutions that enable in silico novel antibody and drug discovery .. Technologies :",
"Clinical Bioinformatics Analyst I . Develop annotated genomic profiles of somatic aberrations based on massively parallel sequencing Next Generation Sequencing or NGS data in cancer patient samples study . Review genomic variant calls using propriety and publicly available tools , including but not limited to the Integrative Genomics Viewer IGV , in close collaboration with the scientific team Provide test results according to Standard Operation Procedures SOPs with the best possible quality within defined turn around times . Collaborate with technical teams in specifying requirements for tools to enhance workflow efficiency and robustness . Research Studying at Temple University has allowed me to pursue research with world reknown factuly and state of the art equipment . I am combining my knowledge of science in genetics with programming skills in Python 3 and R to assist in the advancement in knowledge . I pursued Bioinformatic research in the Institute of Genomics and Evolutionary Medicine iGEM at Temple University in Cancer Phylogenetics . Through this position , I have had the opportunity to present my research in university sponsored poster presentations and publish as a co author in several peer reviewed journals . Education I have completed my undergraduate degree with a Bachelor of Science in Biology in Spring 2021 Aspirations After finishing my studies , I will be pursuing a full time opportunity to strengthen my experience in a laboratory setting . In the future , I hope to pursue further education in Molecular Biology , Biostatistics , Computational Biology , or Bioinformatics . With my background in cancer research , I am especially interested in precision medicine and pharmacogenomics .. Technologies :",
"Global Study Manager . Clinical trials project management , budget monitoring , risk timeline management . I work as a Global Study Manager with a background in platform management , Structure Biology Cryo electron microscopy . Clinical trials project management Risk , timelines milestones management Budgeting monitoring Team coordination management Accountable for the implementation , monitoring and reporting of performance metrics Key contact for clients ; Liaison between Client Data management Research platform management . Technologies : CryoEM",
"Senior Research Associate . Senior Research Associate , Biology at Nura Bio formerly Proneurotech , Inc. https : nurabio.com Designed and executed critical experiments enabling a gene to structure workflow to support pipeline discovery programs Cloned and screened protein fusion constructs for recombinant expression of proteins prone to aggregation Purified soluble , insoluble , membrane bound bacterial and mammalian proteins to support small molecule drug discovery Optimized purification workflows using chromatography methods to improve protein yield , sample quality homogeneity Characterized protein using biophysical Octet BLI , SPR , DSF and biochemical activity assay techniques to assess quality Screened and optimized crystallization conditions to obtain well diffracting crystals to collect high quality structural data Performed crystal manipulations like crystal soak , crystal harvest , and cryoprotection to enable synchrotron data collection Processed raw datasets and solved protein structures using advanced crystallography software like HKL2000 , Phenix , Coot Managed the onboarding of Benchling , an electronic lab notebook and sample management platform , for the company . I am currently a Protein Biochemistry Research associate at Nura Bio formerly Proneurotech , Inc. specializing in Structural Biology and Molecular Biology . I recognize myself as an independent scientific researcher with over two years experience working in oncology and antibacterial drug discovery research . I have successfully demonstrated ability to work in a fast paced , collaborative work environment with attention to data reproducibility . I regard myself as an creative , flexible , adaptable , and accountable biotechnology professional with a background and experience in diverse applications of molecular biology and protein biochemistry .. Technologies : BLI;SPR;DSF",proteins;small molecules;characterization;expression;interaction;screening
Assistant Professor . Structure function studies between selected histone demethylases nucleosomes and their role in epigenetic regulation and interactions potential drug molecule . I 'm a research scientist actively involved in projects understanding epigenetics and oxidative stress from a societal point of view .. Technologies : Xray;CryoEM,proteins;interaction;structure
"Senior Postdoctoral Fellow . Structural biology of virus host interactions and structure based design of improved vaccines . Experienced research scientist with expertise in structural biology and protein science . Skilled in the application Cryo EM , X ray crystallography and biophysics to determine the atomic structure of proteins and viruses and elucidate structure function relationships , with the aim of developing novel therapeutics and vaccines .. Technologies : Xray;CryoEM",proteins;characterization;interaction;structure
"Scientist , Protein Science . . Integrative scientist with a focus on structural biology . Experienced with the full pipeline of mutagenesis , protein expression , purification and structural determination of multiple , large protein complexes from diverse cell types . Well versed in generating and characterizing large DNA protein complexes utilizing multiple biochemical assays , including western blotting , negative stain electron microscopy and the full pipeline of cryo EM from data collection Talos Arctica to data processing cryoSPARC , Relion etc . . Effective leader who has managed multiple students who have since moved to respectable positions . Constructive communicator , reflected by several award earning presentations , with ample experience collaborating in a team . . Technologies : CryoEM",proteins;structure
Associate Computational Scientist . . . Technologies :,
"Senior Scientist protein crystallography . Aim : Structural based drug design , protein production , biophysics Protein engineering , protein production , crystallization and structure determination Hit validation and characterisation , ligand binding experiments Intact MS , ITC , thermalshift assays Project management : experimental design , work schedules , resource planning , proposal writing , regular client updates . Enjoying challenges , I am an experienced biochemist with a demonstrated history of working in the biotechnology and pharmaceuticals industries . Skilled in Protein Chemistry , Biophysics , Biotechnology , Structural Biology , and Drug Discovery . Strong research professional with a PhD in biosciences from Ecole Polytechnique , France .. Technologies : ITC",molecular glues;nucleic acids;proteins;small molecules;engineering;interaction;structure
"Biochemist . Biophysical analysis of proteins and peptides e.g FT IR , DLS , Fluorescence , absorbance and Thioflavin T based fibrillation analysis . ELISA analysis GMP laboratory production support and problem solving Development , robustness and validation of analysis . . Technologies : SLS DLS",peptides;proteins;characterization
"Postdoctoral Scholar . . Dr. Zhang has a broad background in molecular biology , biochemistry , biophysics and pharmacology , with expertise in isolating membrane proteins , assembling lipid systems , imaging signaling pathways , processing massive data and detailing dynamic information . G protein coupled receptors GPCRs and channels play the vital role in signal transduction and comprise nearly one third of membrane proteins which targeted by approximately half of drugs marketed . He has been working on molecular understanding of their functionalities reconstituted into a lipid environment by combining method development , biochemical assay and single particle cryo EM . He devotes himself to exploring the power of cryo EM for visualizing transitional intermediates during dynamic processes in atomic detail .. Technologies : CryoEM",membrane proteins;structure
"Senior Computational Biologist . Led the pipeline development and data analysis for multiplexed cell permeability assays Led customized NGS pipeline development , data analysis and biomarker discovery to support the company 's leading beta catenin program . Produced impactful results that helped the company reaching in vitro PoC and in vivo milestones , and obtain series C funding Initiated and performed machine learning studies to predict peptide properties and cell line sensitivity , and to identify biomarkers Developed visualization tools . Specialties : bioinformatics , computational biology , algorithm and software development , proteomics and genomics , cancer , immunology . Technologies :",
"Associate Manager . Associate Manager in DAPI Analytical Support , Biophysics Support IT Equipment . . Technologies :",
"Manager , Cell Informatics . . I m a result driven , self motivated and qualified computer scientist and computational biologist with 20 years of experience in high quality bioinformatics service and advanced analytics provision for genomic biomedical research and drug discovery . Specialties : Bioinformatics , Computational Biology , High throughput Sequencing Data Analysis , High throughput Phenotyping , Advanced Analytics , HPC , Distributed Systems , Cloud Computing , Database Applications , Object Oriented Software Design and Programming . Technologies :",
"Senior Scientist , Computational Biology . . . Technologies :",
Senior Director . . . Technologies :,
"Associate Scientist . . Highly motivated graduate from the University of Rochester , seeking work experience in the field of biological sciences . Specifically interested in industrial laboratories working in cellular biology and genomics , but very open to opportunities related to other fields of biology .. Technologies :",
"Research Analyst . . International healthcare equity research . CFA charterholder . Multidisciplinary academic and industry background in computer science , bioinformatics , genetics , cellular and molecular biology . Professional Postdoctoral Master 's degree in Bioscience management . Passed Regulatory Affairs Certification exam in 2014 . . Technologies :",
"Advisor Biology . . I am a result oriented protein biochemist biophysicist with 14 years of experience in the field of structural biology with the aspiration to apply my knowledge of protein structure function relationship in developing products that would have a direct impact on society . In that regard , I am specifically interested in becoming a part of the pharmaceutical healthcare sector , to develop drugs and vaccines against diseases and or molecular diagnostic solutions . Highlights : An independent thinker with outstanding technical skills in the area of protein chemistry that range from expression purification of soluble and membrane proteins to their complete characterization , structure determination , and their interactions with other proteins ligands . A problem solving individual with highly analytical mind and effective time management skills , who has successfully completed several difficult research projects that have provided answers to complex biological questions , resulting in 10 publications . An excellent team player with exceptional communication skills and experience of working in multidisciplinary environments and mentoring more than 15 researchers at various career levels . Technical skills : Cloning , expression purification of soluble and membrane proteins . Biochemical characterization of proteins , enzymatic assays . Structural biology : X ray crystallography , NMR , electron microscopy negative stain , cryo , microED Assay development for protein protein and protein ligand interactions using biophysical techniques like 2D HSQC NMR , fluorescence , CD spectroscopy , MST , ITC , SEC MALS . Computational skills : Shell Scripting ; programming in R , protein DNA sequence analysis ; protein ligand docking ; protein homology modeling ; molecular visualization modeling analysis software Coot , PyMol , and Chimera . About the background photo : that 's one place and its inhabitants that I care about , above all . Not that I do n't care about the rest of the universe , but that seems to be in no avoidable danger any time soon .. Technologies : Xray;ITC;MST;NMR",membrane proteins;proteins;characterization;interaction;structure
Principal Scientist Pharmacology Team Leader . . Experienced Scientist with a demonstrated history of working in the biotechnology industry . Skilled in Biomedical Engineering Quantitative Systems Pharmacology . Strong research professional with a Doctor of Philosophy PhD focused in Bioengineering and Biomedical Engineering from The Johns Hopkins University School of Medicine . . Technologies :,
"Research Fellow . . Alessia Visconti 's research activity deals with the study of the genetics of human diseases . Her work focuses on the identification of genetic and epigenetics variants influencing the risk of common diseases or of related quantitative phenotypes . She has also worked on the problem of knowledge discovery in biological data , developing new approaches tailored to solve biological tasks , and on the reverse engineering of gene regulatory networks . More recently she became interested in the studying of the human gut metagenome .. Technologies :",
"Sr . Informatics Data Scientist . . Research data scientist working in the fields of algorithm design and data analysis with strong programming background . Experience designing custom algorithms predictive , recommendations and others , designing and training AI models , designing and querying relational databases , analyzing scientific data , rapid prototyping in scripting languages and developing production level software . . Technologies :",
"Director , Head of Screening . . 20 years of experience in pharmaceutical drug discovery as a team player and project leader in multidisciplinary teams . Expert in oncology research , signal transduction , cell cycle , immune oncology , DNA damage signalling . Assay development and HTS expert in biochemical and cell based screening . Management of and negotiations with external collaboration and outsourcing partners . Since January 2020 heading the high throughput screening team of 40 scientists and technicians at the Innovation Campus Berlin at Bayer AG .. Technologies :",small molecules;screening
"QC Chemist . Troubleshooting of enzyme activity methods Global quality meetings Internal project management Ad hoc problem solving Evaluation of data Leadership of instrument teams Leadership of LEAN board meetings , including coordination Internal auditor ISO9001:2015 . PhD : Characterization and protein engineering of galactanase in a thesis titled understanding and predicting thermostability : galactanases as experimental model system under the main supervision of associated professor Leila Lo Leggio . M.Sc : Characterization of galactanase , Structure determination of chitosanase and crystallization of galactosidase in a thesis titled Structural and biochemical studies of enzymes hydrolysing glycosidic bonds . B.Sc : Investigation of the kinetic mechanism of sorbitol dehydrogenase .. Technologies :",enzymes;characterization
Chief Scientific Officer . . . Technologies :,
"Assistant Professor . . The Li Group at UCLA develops materials for energy and environmental applications . To make breakthroughs in these areas , advanced electron microscopy techniques e.g. cryo EM will be developed to establish fundamental guiding principles for the design and synthesis of next generation materials . More info : https : sites.google.com view li groupucla home https : samueli.ucla.edu people yuzhang li . Technologies : CryoEM",
"Professor Emeritus Director of Research . Structural Biology of Receptor Activation and DNA Repair , Structural Bioinformatics and Structure guided Fragment based Drug Discovery . Tom Blundell researches on molecular and structural biology of growth factors , receptor activation , signal transduction and DNA repair , important in cancer and other diseases . He has published 500 research papers , including 30 in Nature . He was founding CEO of BBSRC 1991 1996 Chair from 2009 , Chairman of Royal Commission on Environment 1998 2005 , Deputy Chair of Institute of Cancer Research since 2008 and President of UK Science Council since 2011 . He has written extensive software for structural bioinformatics and developed new approaches to structure guided and fragment based drug discovery . In 1999 he co founded Astex Therapeutics , an oncology company that has eight drugs in clinical trials and that was sold in 2013 as Astex Pharma to Otsuka for 886 million . In his academic lab he is focusing on the design of new antimicrobials for tuberculosis funded by FP7 MM4 TB and Gates HIT TB and targeting protein protein interactions for cancer therapeutics .. Technologies :",proteins;small molecules;screening;structure
"Researcher . Project : Structural dynamics of membrane transport proteins Key techniques : Protein production and purification , Nanodisc technology , Time Resolved X ray Solution Scattering TR XSS , and Transmission Electron Microscopy TEM . I have a PhD in biochemistry and I am currently working as a postdoctoral researcher at Ume University , Sweden . My research focuses on structural and biophysical studies of membrane transport proteins . Specialties : Membrane protein production and purification , protein reconstitution in liposomes and nanodiscs , biochemical and biophysical analysis of protein complexes . I am currently doing structural biology using Time Resolved X ray Solution Scattering TR XSS and Transmission Electron Microscopy TEM .. Technologies : Xray",membrane proteins;characterization
"Centre Director Systems Biology and Bioinformatics . This Centre co ordinates research , training , facilities and outreach in Bioinformatics and Systems Biology at Imperial College London . . An experience protein bioinformatician and chemoinformatician in the university sector with experience of a start up . Experience in developing world leading algorithms to model protein structure , function , interactions , networks and systems together with development of chemoinformatics software to identify novel hits and leads for drug discovery . Available for consultancy , lecturing and contract research . Scientific management Experience at co ordinating research teams Director of Centre for Integrative Systems Biology and Bioinformatics at Imperial College London see www.imperial.ac.uk cisbio Bioinformatics Head of protein bioinformatics group that developed the Phyre2 web server for protein structure prediction that has over 500,000 hits by the community . www.sbg.bio.ic.ac.uk . Developed other protein modelling tools including protein docking and protein function prediction . Systems biology Research into algorithms for the comparison of protein protein networks and into gap filling in metabolic networks . Analysis of nsSNPs from a network perspective . Medical informatics Developer of new approaches to understand the effect of nsSNPS on proteins and their likelihood to cause disease . Spin out Founder and Director of Equinox Pharma Ltd www.equinoxpharma.com which exploits chemoinformatics for drug discovery . Computer aided drug discovery Co developer of Equinox s INDDEx approach for logic based drug discovery which finds comprehensible rules for structure activity relationships and performs exceptionally well at scaffold hopping in computational screening to find novel hits . Scientific journals Experience at scientific publishing via journal boards including Associate Editor of Journal of Molecular Biology . Teaching Extensive experience of postgraduate and undergraduate teaching in bioinformatics and theoretical systems biology Deputy Director of MSc in Bioinformatics and Theoretical Systems Biology at Imperial College .. Technologies :",
"Scientific Advisor . Incubating transformative solutions to central challenges to biotechnology . . Systems biologist focused on developing comprehensive computational models to enable personalized and predictive medicine and rational bioengineering . Focused on innovative research and engineering . Experienced in molecular cell biology , computational modeling , software engineering , and scientific visualization . Committed to teaching and mentorship .. Technologies :",
"Principal Scientist . . Specialties : Machine Learning , Optimization , Data Mining , Operations Research , Artificial Intelligence , Game Theory , Multi Agent Systems , Robotics , Algorithms , Computational Complexity , Bioinformatics , Digital Marketing .. Technologies :",
"Research Associate IV . . Experienced Protein Scientist with a demonstrated history of working in the biochemistry biophysics research . Skilled in Protein biochemistry , Fluorescence spectrometry , High throughput assay development , Biotechnology , Nuclear Magnetic Resonance NMR , CD spectroscopy . Strong research professional with a Doctor of Philosophy focused in Pharmaceutical and Bioanalytical Chemistry , and Master 's in Computer Aided Drug Design . . Technologies : NMR",proteins;characterization;screening
"Akademischer Mitarbeiter . . I am a Doctoral Student at the Institue for protein Biochemistry , University of Ulm . I work in the field of Structure Biology in the Cryo Electron Microscopy section .. Technologies : CryoEM",proteins;structure
"Computational Research Scientist . . Experienced Computational Biologist with a demonstrated history of working in the research industry . Skilled in Research in structural biology , Data Analysis , Programming and Methods development . Strong research professional with a Doctor of Philosophy Ph.D. in Biophysics from Institute of Mathematical Problems of Biology of Russian Academy of Sciences . Experience in Computational biology at Lawrence Berkeley National Laboratory USA . . Technologies :",
"Scientist II . . Chemical engineering Ph . D with a diverse background in bioprocessing , biochemical engineering , and cell and gene therapy . Skilled in molecular biology techniques , bioprocess development , and computational methods . Demonstrated leader and mentor .. Technologies :",
"Principal Scientist . . Current Industry Expertise : ADME Sciences , PBPK modeling , PK PD Efficacy , NONMEM and QSP modeling and simulation M S in Inflammation and Immunology Portfolio projects in Rheumatoid Arthritis , Inflammatory Bowel Disease , Topical Applications and Internal Medicine Obesity Academic Expertise : Systems Biology , Signal Transduction , Arts of Modeling , Simulation and Optimization Professional Service : Science camps for high school students , Editorial and reviewer duties , Mentoring students belonging to the LGBTQ spectrum in STEM fields I prefer working with people with joy in their hearts , courage in their actions , excellence in their pursuits , equity in their relationships . Technologies :",
"Nanofabrication Research Service Center NRSC Equipment Trainer and Maintenance . At Texas State University , Nanofabrication Research Service Center NRSC facilitates a large clean room area occupied by different deposition , etching and device manufacturing equipment . Besides working as equipment trainer , I also participate in HV UHV equipment maintenance e.g. , sputter target replacement , cryo pump regeneration , deposition chamber cleaning etc . . Nanofabrication Research Service Center NRSC equipment trainer and maintenance . Participated in project based teamwork graduate level experimental course works on thin films deposition characterization techniques and have a strong hands on research experience in cleanroom area with the expertise on semiconductor fab processing e.g. thin films deposition , device fabrication and their characterizations . Specialties : Growth : PVD : DC RF Sputtering , Electron Beam Evaporation , Pulsed Laser Deposition PLD , Atomic Layer Deposition ALD Metrology Characterizations : Ellipsometry , XRD , XRR , AFM , SEM , FIB , XPS , Electrical Characterizations I V , C V , Hall Measurements . Fab processing : Design of Experiment , Wet Etch , Thin Film Deposition , Photolithography , Lift off . Devices : Schottky Diodes , RRAM , MOSCAP . Maintenance : Nanofabrication Research Service Center NRSC equipment trainer , HV UHV equipment maintenance e.g. , sputter target replacement , cryo pump regeneration , deposition chamber cleaning etc . Programming Language : Python , MATLAB , Predictive Data Science Machine Learning Statistical Process Control SPC . Technologies :",
"Postdoctoral Researcher . Using cutting edge methods to directly visualize gene products in cells in their living state with special emphasis on cytoskeletal assemblies and molecular motors Experience in the gene to structure pipeline , including construct design , standard molecular biology techniques , recombinant protein expression , followed by in situ molecular imaging using cryo electron tomography cryo ET Method development for cryo electron microscopy cryo EM Utilization of cryo FIB milling of frozen hydrated biological samples Experience using software for 3D reconstructions of cryo tomography samples Experience characterizing the performance of an imaging system such as a direct detection camera or energy filtered detector . Dedicated and persistent researcher with a solid background in biochemistry , biophysics , molecular and structural biology . Extensive experience in biochemical and biophysical characterization of nucleic acid and protein , recombinant protein expression and purification , X ray protein crystallography , and CryoEM ET .. Technologies : Xray;CryoEM",nucleic acids;proteins;expression;structure
". . A young professional with clinical pharmacy working experience in Estonia , Spain and Portugal . Eagerness to venture into the scientific world led me to pursue a master 's degree in Pharmaceutical Sciences at KU . The culmination of my time at KU is a 60 ECTS project on the functional studies of GPCR G protein interface determining selectivity with Rasmussen lab .. Technologies :",
"Turing Research Fellow . Building a research team in computational biology , particularly developing new statistical and computational methods for designing genetic experiments . see https : daphneezer.wordpress.com and https : scholar.google.co.uk citations user kY0ZQoIAAAAJ hl en An EPSRC funded research associate position is available in my group . PhD students are encouraged to apply through the Alan Turing Institute . How can we utilise crowdsourced science to its full potential How can we optimise the design of experiments to save time and effort while maximising biological insights How can we develop new statistical tools to extract more meaning from existing datasets such as normalising them to be able to do meta analysis or utilising the functional structure of the data to have a more detailed analysis . . Technologies :",
"Senior Application Scientist . . I am a life scientist with a background in developmental biology . My research has focussed on questions of nano biosafety , regulation of stem cells , maintenance of cell polarity , and neuropeptide GPCR signalling systems . I approached these problems with methods that range from in silico to in vitro and in vivo . I have successfully driven research projects in international and interdisciplinary collaborations and I thrive on the synergy created by professionals that share a vision and strive after the same goal . For many years I have been teaching students in cell biology , developmental biology and human physiology . My colleagues appreciate my analytical and creative approach to problem solving and that I am always willing to share my knowledge and ideas or lend a helping hand . Students and friends value my ability to explain complex subjects with passion and patience . In my working environment I value structure , transparency , direct communication , and a positive , open atmosphere .. Technologies :",
". . J'ai obtenu mon doctorat en biologie structurale en 2020 durant lequel j'ai pratiqu et g rer divers projets de mod lisation mol culaire , traitements et interpr tation de donn es de microscopie lectronique . J'ai effectu une ann e de postdoctorat dans laquelle j'ai acquis de nouvelles exp riences en microscopie lectronique et plus pr cis ment en sonde ionique focalis e FIB . Mes domaines de pr dilection sont la microscopie lectronique et la mod lisation mol culaire . J'ai pu explorer et pratiquer diverses m thodes do nt la cryo EM en particules simples , cryo tomographie et FIB . J'ai travaill sous environnement Linux et Windows , je maitrise les outils du package Microsoft Powerpoint , Word , etc ainsi qu'une panoplie de logiciels sp cialis s dans les domaines de la microscopie lectronique et mod lisation mol culaire . Je suis d sormais la recherche d'une nouvelle opportunit dans une entreprise dynamique dans laquelle me projeter pour m ' panouir professionnellement et long terme . Je suis galement ouvert des propositions en dehors de mon champ d'expertise puisque j'aime apprendre , et d velopper de nouvelles comp tences . N'h sitez pas me contacter mes coordonn es de mon profil LinkedIn pour en discuter .. Technologies : CryoEM",structure
"Postdoctoral Scholar . Recombinant Natural sourced membrane ion channel reconstitution in lipid nanodisc Sample preparation for negative stain imaging , cryoEM grids frizzing , screening Data acquisition using SerialEM in Titan Krios , image processing in relion , cryoSPARC . A benchmark structural biologist and protein biochemist with 7 years experience gleaned a handsome amount of ideas , methods , techniques now time for transferring those scientific findings to the community . Sharpened the knot solving aptitude in research from stubborn protein expression , purification , enzyme catalysis , product formation to product separation , sketching the project plan and bring it to the benchmark . Conducted research in different platform including Protein Biochemistry Structural Biology CryoEM and X ray crystallography Bioanalytical Chemistry converging those application in one point making and characterizing multi variant scaffold of therapeutic agent in drug discovery . Research Skills : Molecular Cell Biology : Construct design dibac , multibac , PCR , Agarose gel electrophoresis , DNA gel purification , DNA pieces assembly , Plasmid preparation , Transformation DH5 alpha transposition DH10BAC , Bacmid isolation . Protein Expression : Mammalian cell culture Integral Membrane Protein expression in HEK293 cell lines . Insect cell culture Preparation of recombinant baculoviruses and gene expression with Bac to Bac expression system , membrane protein expression in sf9 cells , High five cells . Bacterial cell culture Protein expression in E. coli strain including BL21 DE3 , SoluBL21 , T7 Express lysY Iq . Protein Purification : Recombinant and native sourced protein purification by Affinity SEC Ion Exchange Chromatography AKTA FPLC Unicorn , BioRad ChromLab Protein Complex Assembly : Multiprotein complex association of megadalton size analyzed by SEC MALS , Size exclusion chromatography and immobilized by crosslinking for cryoEM structure determination . Structural Biology : Negative stain imaging using Tecnai T12 transmission elelctron microscopy CryoEM sample preparation , grids freezing , grids screening using Glacios Cryo TEM TEM single particle data processing in Relion , cryoSPARC . Separation Detection : High Performance Liquid Chromatography HPLC , MALDI TOF , NMR Spectroscopy others : Western Blot , UV vis , Fluorescence spectroscopy , Dynamic Light Scattering DLS , Differential Scanning Fluorimetry DSF , Isothermal Titration Calorimetry ITC SKETCH THE INNOVATION IN THE SKYBOARD , MAKE IT HAPPEN , HAND IT IN TO THE COMMUNITY Email : Kazi.lingkon outlook.com Phone : 419 973 6660 . Technologies : Xray;ITC;SLS DLS;DSF;NMR",membrane proteins;proteins;characterization;structure
Graduate Student . . Interested in cryo EM and cryo ET methodologies and its applications to neurobiology and cell biology . Currently a PhD student in Elizabeth Wright 's lab in the Department of Biochemistry .. Technologies : CryoEM,proteins;structure
Lead Biology Project Manager . . I am passionate about science and drug discovery enabling to dissolve diseases and bring benefit to the patients . Currently I am working in an interdisciplinary team as project lead and scientist . During my PhD I worked on an interuniversity target discovery project . In my future career I would love to proceed in target discovery and project management in a biotech pharma environment . . Technologies :,small molecules
"Senior Expert Science Technology . . I am currently a formulation project leader at Novartis technical research and development . . As formulation project leader I executed a number of early phase projects including complex parenteral dosage form from preclinical to clinical stage . I possess a strong understanding of formulation and process development , quality improvement techniques , root cause investigation , risk assessment etc . I have gained good knowledge of scale up GMP manufacturing from lab to pilot plant for complex parenteral formulations e. g. , PLGA microparticles , oparticle , liposomes , sgRNA , etc . . I supervised several postdocs and trainees . I am actively collaborating with universities around the globe and I believe collaboration is the key to great innovations . . for info about my publications see below : . https : scholar . google . com citations user 3Gf6Z4kAAAAJ hl en . Technologies :",
Head of Research Software Engineering . . . Technologies :,
"Project Director , Research Services Division . . Medicinal chemist and project leader with over ten year experience in drug discovery development . Strong cutting edge knowledge and working experience on modern medicinal chemistry , drug design , screening tools for drug discovery , and lead optimization . Demonstrate leadership , establish and manage collaborations with internal external collaborators , scientific advisors and consultants . Track record on scientific publications and recognized review experience for top ranked peer reviewed journals in medicinal chemistry . Multi lingual speaker and excellent communicator deliver comprehensive scientific presentations to internal and external collaborators and stakeholders . . Key Skills : organic synthesis , chemo enzymatic synthesis , carbohydrate chemistry , analytical chemistry , organic process R D , computer aided drug design , lead optimization , structure activity relationship SAR , pharmacodynamic pharmacokinetic ADME studies , combinatorial library screening , high throughput screening , liposome oparticle formulations , glycan polymer glycan protein conjugation , in vitro protein ligand binding assays , hands on animal models in immunology , scientific writing reviewing . Technologies : ITC;SPR;FP",proteins;small molecules;interaction;screening
"Research Specialist in biomolecular NMR and scientific computing . Major expertise in structural molecular biology , data processing , data analytics , biomolecular NMR , biomedical project management and scientific computing . . The Biomolecular NMR Spectroscopy Platform BNSP at the ETH in Z rich serves the advancement of research in the area of nuclear magnetic resonance NMR within the Department of Biology . . . I have a profound interest in bio medical research , especially biomolecular NMR , and cutting edge information technology . 16 years of experience as a scientist in the pharmaceutical industry and academia . Record of achievements in scientific computing data science machine learning and statistical modeling : delivered data mining solutions for pharmaceutical research . . Strong track record of scientific achievements in biomedical research , especially biomolecular nuclear magnetic resonance NMR . Successfully contributed to drug discovery project in major pharmaceutical company . Expert for lead discovery , fragment based drug discovery and structure based drug design . Therapeutic areas : Oncology , Infectious disease , Inflammation , Neuroscience . I have more than ten years of experience as a project manager in biomedical research and contributed to various successful drug discovery projects in oncology , inflammation and cardiovascular diseases as an expert for lead finding and early stage pharmaceutical research . My skills cover structure determination of proteins and RNA using NMR , computational biology , molecular modeling , structure based drug design , cheminformatics , protein ligand docking , MD , homology modeling , chemical library design , biophysical studies for proteins and RNA NMR , DSF , SPR , ITC , DSC . Assay technologies TR FRET , FP , FLT . Specific computational skills : . Data science , big data , data mining , KNIME , machine learning , deep learning , Python : pandas and scikit learn , R , Linux , UNIX , MS Windows , Mac OS , AWS , Scripting , bash , tcsh , awk , sed , Java SE8 , C , Web development , HTML , CSS , JavaScript , Database , SQL and noSQL , Molecular modeling , computational biology , cheminformatics , NMR , MOE , Pymol , RDKit , CHARMM , Matlab , Mathematica . Technologies : ITC;DSC;SPR;DSF;NMR;FP;FRET",proteins;small molecules;interaction;screening;structure
"PHD Student . . I 'm a person with a drive for immunology and the molecular science behind possible treatment approaches against cancer , viral infections , or immunodeficiencies . The study projects I 've done have been focusing on targeted therapy and personalized medicine , fx . antibody delivery across the blood brain barrier , detection of tumor antigens , targeted therapy via utilization of dendritic cells and monocytes including adoptive cells therapy as another immuno therapeutical option . Additionally , projects about the positive effect of laughter on acute pain and surgical treatment options against obesity in relation to public health have been my projects during the first years as medicine with industrial specialization student at Aalborg University . My latest project at the Department of Clinical Immunology , at AAUH , was about developing a biological scientific screening tool in order to diagnose autoimmune illnesses . The screening tool can detect autoantibodies reactive towards essential signaling protein receptors as the G protein coupled receptors GPCR such as the beta 2 adrenergic receptor or the muscarinic receptor 3 or 4 . The project has also implemented a functional assay to detect the cellular activation to these receptors in the milieu of autoantibodies from plasma samples achieved from autoimmune ill patients . As a person , I 'm ambitious and committed to my work , especially if the work is immuno physiology and the work leads to new knowledge . Also , I acknowledge my team members , fx . what role they want to play in a group . I myself , am an initiator and can very well function as a leader of a group . As an example , I 'm a board member of the Dansk Retriever Klub Region Nordjylland , where I organize gun dog training , working tests , and hunting related events . I sometimes participate with my own working dog , a dark colored golden retriever . If I may say so , I do have skills with throwing pigeons for the hunting dogs . Feel free to ask me anything about this area , and I will elaborate . During my time at Aalborg University , I volunteered as the chairman for a university run called UniRun from 2013 2016 . When I 'm not working I love a fresh run , nice food , and good company from friends , colleagues , or my partner . So if you want to experience me fully enjoyed , you can take me out running , followed by a light lunch or delightful dinner and talk about dog training or immunology . Cover image borrowed from Cambridge Bioscience https : www.bioscience.co.uk cpl robust neutrophil extracellular trap assay kit . Technologies :",antibodies;membrane proteins;interaction
"Statistical Genetics Researcher . PIs : Alexander Gusev and Alkes Price Developed statistical methods to characterize the genetic basis of complex diseases including diabetes , schizophrenia , and cancer in human populations Derived a novel method of moments estimator of a quantity known as heritability mediated by gene expression levels . Established unbiasedness of estimator via derivations and simulations . Applied method to real human disease genetics data from UK Biobank and RNA seq data from the Genotype Tissue Expression Consortium . Wrote first author publication in Nature Genetics cited 100 times since publication in 2020 . Check out my personal website here : https : douglasyao.github.io I 'm a PhD student in the Bioinformatics and Integrative Genomics program at Harvard Medical School . My interests are in developing statistical methods to understand the genetic mechanisms of complex disorders such as diabetes , schizophrenia , and cancer from genome wide association studies . I 'm also developing multiplexing strategies for high throughput cell based assays that read out the full transcriptome across 1000s of treatment conditions such as CRISPR perturbations and drug treatments , with the goal of increasing the throughput of such assays by 1 to several orders of magnitude over existing approaches . . Technologies :",
"Manager of Assay Research and Development . . I am a collaborative and results driven Biochemist . I enjoying mentoring other scientists , and especially enjoy taking a deep dive into seemingly intractable technical problems . Some of my specific skills include : Assay development Training of other scientists Conformance to current Good Manufacturing Practices cGMP Structural biology X ray crystallography and cryo EM Recombinant protein expression and purification Synthesis and purification of nucleic acids High throughput robotics Molecular Biology . Technologies : Xray;CryoEM",nucleic acids;proteins;structure
"Research Engineer CDI . Member of the molecular biophysics core facility in Institut Pasteur . Characterization of secondary and tertiary structure of biomolecules in solution . Characterization of hydrodynamic properties of biomolecules in solution such as intrinsic viscosity , molecular mass , oligomerization state , stochiometry and interactions . Official implementation in 2017 of the service of Quality control of purified proteins mostly dedicated to Institut Pasteur teams . More than 500 protein samples have been tested since the service creation . Spread knowledge with the cours de Biochimie des prot ines and the Integrative and cellular structural biology EMBO course . Advice users and research teams . Practical skills : Analytical ultracentrifugation XL I and Optima Static light scattering Omnisec Dynamic light scattering DynamoPlatereader III MALDI TOF UltrafleXtreme NanoDSF Prometheus Viscosizer TD Circular dichroism J1500 UV and fluorescence spectroscopy I train people on these instruments . . Research Engineer at the molecular biophysics facility , Institut Pasteur . Since 2022 : In charge of the spectroscopic line with circular dichroism device , stationary phase fluorimetry , differential scanning fluorimetry and UV spectroscopy . The responsibility includes the training of new users , the maintenance and know how of instruments , the understanding of the technology allowing the monitoring of short , medium and long term interaction with researchers , beginners or experts who need to complete their studies by biophysical measurements . Since 2017 : I run the quality control of purified proteins service . This service was officially launched in 2017 to help the research teams of Institut Pasteur and outside that had troubles in purifying their protein of interest and especially had difficulty to complete their downstream applications Cryo EM , X Ray crystallography , activity tests , binding tests , etc . I have set up an experimental workflow that allows research teams to obtain a full qualitative control QC of their purified proteins using DLS , MALDI TOF , UV spectroscopy , nanoDSF and to help them to identify conditions in which their proteins is best behaved . Currently , around 350 proteins year are analyzed . Since 2015 : I collaborate with research teams of Institut Pasteur and other research centers on the characterization of the mass , size , shape , and stoichiometry of their biomolecules . To solve these questions , I use several and complementary approaches such as analytical ultracentrifugation Optima AUC and Proteome Lab XLI , dynamic light scattering DynaPro PlateReader 3 , SEC MALS Omnisec and Taylor Dispersion Viscosizer TD . As some questions are more challenging than others , I implement new experimental strategy using my expertise . This added value is recognized in scientific papers that I have co authored https : scholar.google.com citations user g8y3NR8AAAAJ hl fr oi ao . Development part : I have published work on the determination of intrinsic viscosities of biomolecules using the Viscosizer TD . https : doi.org 10.1007 s00249 020 01492 3 . Technologies : Xray;CryoEM;SLS DLS;AUC;DSF;CD",proteins;characterization;structure
"Postdoctoral Fellow . . AHA Postdoctoral Fellow interested in proteins that help shape and organize cellular organelles and their involvement in human diseases . I use biochemistry and structural studies , like cryo ET , cryo EM and X ray Crystallography to understand how protein complexes function at membranes .. Technologies : Xray;CryoEM",membrane proteins;structure
"Bioanalytical Scientific Monitor . Bionalytical Monitor for Clinical studies and outsourcing . Highly motivated and pro active scientist with almost fifth teen years experience in drug discovery and more than five years in drug development in regulated environment . Area of expertise : . Hybridoma and B Cell managing for Antibody discovery campaign . managing and programming semi and full automated platforms Tecan , Hamilton , Beckman Coulter , Gyros . cell biology , biochemistry , cell imaging . assay development and validation for PK PD IG and study samples analysisin GxP regulated environment . data managing with good hand on of statistical software . implementation of secured and data with electronic notebook eLN in regulated environment . training to end user for software and new technologies . Technologies :",antibodies;developing
"Scientist Lab Manager . . Specialties : I have 10 years of experience with animal cell cultivation in suspension and adherence ; expertise in cultivation process development , small and pilot scale . During this time , I have taken part in different projects for process development for CHO HEK cells , proliferation of human cells for biopharmaceutical process optimisation , including production of biopharmaceutical protein antibody , glycoprotein in view of clinical Phase1 for toxicological tests or as tool for research . I am working as a lab manager and researcher in Dr. Veronique Chotteau group , CETEG , Dept . Industrial Biotechnology , Engineering Sciences in Chemistry , Biotechnology , and Health , CBH , KTH . I find it stimulating to work in a target oriented environment where I can use my analytical and professional skills . My responsibilities have been coordinating , planning and leading many biopharmaceutical projects with process development optimisation and protein production . I am involved in the execution , data analysis , and documentation . I am also responsible for CETEG day to day activity planning , educational and training of the students and staff . In general , my qualifications and skills have been gained from several years of experiences as a researcher , senior process scientist , project coordinator , project leader , teacher and validating . Moreover , I have also experience with E.coli cultivation process development , Recombinant protein production , process development , fed batch bioreactor cultivations , membrane proteins and surface display molecular biology cell physiology Protein purification Plasmid DNA purification GMP production . Technologies :",antibodies;expression
"Senior Scientist , Microbial Physiology . Participate in initial strain characterization , production , testing and release of cell banks for GMP as well as development of DS production of Live Biotherapeutical products LBP with focus on process development by small scale fermentation platform . Dedicated and experienced scientist with a broad expertise obtained through many years in industrial biotech R D. Motivated by obtaining results in a challenging , honest and good collaboration . Proven results based on in depth knowledge , analytical capabilities and thoroughness . Expertise within microbiology , small scale fermentation , microbial physiology , cell banking , automated assays and data management . Hands on experience in the laboratory . Major achievements include optimization of microbial systems for production of enzymes and biological compounds by development of small scale fermentation methods and assays combined with mutagenesis , automation , high throughput screening and data management . Many improved production strains Aspergillus and Bacillus have been delivered . Recent experiences within strict anaerobic bacteria for live biotherapeutic products . This includes cell banking , strain risk assessments and cell bank characterization phenotypic and genotypic incl . antimicrobial susceptibility testing relevant to potency , safety and GMP production . Also media and process development based on small scale screening platform . COMPETENCES : GENERAL ISO certified work GMP Knowledge of LEAN Electronic documentation Review , reporting Data management Statistical analysis , basic level Reporting , presentations Project management International collaboration Patenting Supervision of technicians Hands on in laboratory TECHNOLOGIES Microbiology Bacteriology Fermentation in MTP , 10 1000 l Fermentation in flask 10 200ml Bioreactor fermentation , 1 L , basic level Microbial physiology Cell banking Assay development Enzymes Lab automation , basic level High throughput screening Strain improvement Classical mutagenesis Molecular biology Bioinformatics , basic level Electrophoresis Immunological methods . Technologies :",
"Research Engineer in biochemistry wetlab of Bioinformatics Unit at Institut Pasteur . Project : Cryo electrotomography study of the Heme Acquisition System produced in bacteria minicells Missions : Optimization of expression in E. coli and purification conditions of membrane and soluble proteins . Optimization of cryo EM conditions for structural analysis of several membrane complexes . Lab Manager of wetlab of the Unit . Skills : Cryo EM : Able to run a complete workflow on a Glacios microscope . Lacey and carbon grid preparation freezing , clipping , loading . Data acquisition for 2d pictures . Tomography should be learned next year with the cryoEM platform of Institut Pasteur of Paris . Biochemostry : autonomous protein purification on AKTA systems affinity chromatography , gel filtration . Lab Manager : PhD students formation , orders , stocks . English : profesionnal use . Langage I mostly use to teach PhD students to our lab techniques . . . Technologies : CryoEM",membrane proteins;proteins;expression;structure
"Senior Scientist , Bioinformatics . . I am a computer scientist working on computational tools that enable new biological insights . My Ph.D. and initial post graduate work were in formal system verification . I then retrained into bioinformatics , seeking to contribute to biomedical applications , and joined the Broad Institute . Topics of my work include assembling of human and pathogen genomes from high throughput sequencing data , finding genetic variants subject to positive selection pressure , and simulating the spread of mutations through populations .. Technologies :",
"Scientist R D Genetics . Primary responsibilities are tending to the data science needs of the long read sequencing team . Developing deep knowledge of core principles of long read sequencing platforms . PacBio , ONT , Bionano Offering computational support to amplification free targeted sequencing experiments on a PacBio Sequel IIe instrument . Assessing off target effects in sequencing data and identifying root causes upstream . Building pipelines and automated workflows for any required data science applications . e.g. primer design Generating clear , comprehensive tables and visualizations for presentations and reports . Attending virtual events and reviewing literature to keep up to date on recent developments in long read sequencing . Further tasks include : Offering insight to optimization of cloud based bioinformatic pipelines . Aiding in instrument installation and networking . Attending meetings with collaborators and taking detailed minutes . . Genomics Scientist at Quest Diagnostics . Master of Science in Biomedical Engineering . Primarily proficient in computational genomics and untargeted metabolomics analysis .. Technologies :",
"Associate Scientific Director . Team lead protein crystallography 5 scientists Structural research and crystallography support for cancer research and cancer immunology projects . Pillar co lead for WP4 protein production in the IMI2 funded EUbOPEN Consortium . BI representative in the SGC and EUbOPEN chemical probe Joint Management Committees . . I am a trained protein crystallographer with ten years of industrial experience . Combining my CRO and drug discovery experience I developed a strong passion for fragment based drug discovery approaches and supporting or leading teams on the difficult track from NTC proposal to H2L chemistry . Currently , I am leading the protein crystallography team at the Boehringer Ingelheim site in Vienna . In my role as BI representative on the SGC Joint Meeting Committee and WP4 Protein production co lead in the IMI funded EUbOpen consortium I support open science initiatives .. Technologies : Xray",proteins;small molecules;engineering;structure
"Senior Bioinformatician for the Department of Immunology . Working with department faculty , staff , and students on analysis of their data using various machine learning and statistical techniques . I also work as a liaison for department personnel with members of IS , Bioinformatics , and the Broad , as well as teaching students and post doc 's . In addition I created and run the departments bioinformatics seminar series , and manage the departments bioinformatics budget . Software development in Perl , MATLAB , R , PHP , Javascript Provide statistics support Use machine learning in the analysis of experimental results Developing software pipelines for image analysis and the the analysis of NGS data Management of multi lab projects leading to publication Developing Division strategy regarding resources for data analysis Responsible for teaching courses on software engineering and data analysis Teach Software development in R Fall Teach RNA seq analysis Spring Teach Applied Statistics Fall Experimental Design Clinical Trial Design Statistics and Sample size Management of Students and research scientists Full stack developer Manage the departments Bioinformatics Seminar Series . Bioinformatician with over 10 years of experience in software engineering , statistics , machine learning , and systems administration . In terms of software development I am a full stack developer , and a system administrator with experience on Windows Server in production environments . I also have over 10 years of experience in software engineering for machine learning and scientific computing applications in biotech . I am currently interested in using machine learning and data science techniques to solve issues with heart failure , and immunology cancer . I now spend most of my time looking for ways to apply statistical models to problems in cancer immunology , usually written in R and python on a SLURM HPC cluster . In addition to my research I teach applied statistics at HMS and am the head teaching fellow for several machine learning courses at Harvard .. Technologies :",
"Senior Research Project Leader . Biotherapeutics Discovery , CRO Manager , Mentor . . Senior Research Project Leader with long term experience in Drug Discovery . Delivered clinical candidates currently in Phase I and II . Project leader in Biotherapeutics Biologics pre clinical research . Experience in antibody discovery , profiling and optimization . Leadership in multidisciplinary and transatlantic teams through internal and external collaborations . Team oriented work style , organized and process driven . Likes to teach and mentor . . Technologies :",antibodies;biologics;engineering;screening
"Senior Scientist . Senior Formulation Scientist at Oral Formulation Research department Solid dosage forms for the oral delivery of peptide and protein therapeutics Enhancing oral bioavailability of biomacromolecules through technological innovation . Background PhD in Pharmaceutical Sciences cum laude , 2016 10 years hands on experience in oral drug delivery , particularly therapeutic peptides and proteins 10 years hands on experience in lipid and or biopolymer based nanoparticles and other advanced drug delivery systems Specialised in permeability solubility stability enhancement , targeted delivery controlled release Gastrointestinal physiology ; digestion and absorption dynamics , including in vitro modeling Solid dosage forms for oral delivery of biologics PK PD analysis Food hydrocolloids and influence of food digestion on oral drug bioavailability Achievements : PhD 2012 2016 : Key contribution to a large scale European project with multiple collaborators and a global leading pharmaceutical company . 2 patents and 4 high impact papers JCR x 2 , ADDR , AM . Outstanding PhD Thesis Award of 2016 . Postdoc 2017 2020 : Successful delivery of government and industry funded research projects . Co supervision of 5 PhD and MSc students . 1 patent and 5 high quality papers JCR , JCIS , etc . . Catalyst Leader Grant from the Royal Society of New Zealand 2019 . Research Officer at Massey University 2020 2021 : Successful management of relationships with multidisciplinary specialists , including partners from academia and from industry . Leading an industry academia cofounded research centre for new product development . Accredited as PhD supervisor . Senior Scientist at Novo Nordisk 2021 Present : Research early development of solid dosage forms for oral peptide delivery Other relevant : Review Editor of 1 international journal Frontiers in Drug Delivery . Reviewer for 20 international journals such as Journal of Controlled Release , Drug Delivery and Translational Research , ACS Biomaterials Science Engineering , Food Hydrocolloids , etc . A few invited talks in universities and conferences .. Technologies :",peptides;developing;formulation
PostDoc Scientist in Antibody Development . . Recent publications : Megabodies expand the nanobody toolkit for protein structure determination by single particle cryo EM . Nature Methods 2021 DOI : https : doi.org 10.1038 s41592 020 01001 6 Single particle cryo EM at atomic resolution . Nature 2020 DOI : ttps : doi.org 10.1038 s41586 020 2829 0 Nanobodies to study protein conformational states . Current Opinion in Structural Biology 2020 DOI : https : doi.org 10.1016 j.sbi.2020.01.003 An improved yeast surface display platform for the screening of nanobody immune libraries . Scientific Reports 2019 DOI : https : doi.org 10.1038 s41598 018 37212 3 Cryo EM structure of the human 1 3 2 GABAA receptor in a lipid bilayer . Nature 2019 DOI : https : doi.org 10.1038 s41586 018 0833 4 GABAA receptor signalling mechanisms revealed by structural pharmacology . Nature 2019 DOI : https : doi.org 10.1038 s41586 018 0832 5 . Technologies : CryoEM,antibodies;structure
"Principal Computational Scientist . . First and foremost , I consider myself to be a lifelong learner . This is the main reason why I decided to pursue a career in multidisciplinary science . Here , I have had the opportunity to develop skills and competencies in a wide range of bleeding edge research techniques in the fields of Bioinformatics , Structural Biology , Molecular Simulation , and Machine Learning . With this diverse , multidisciplinary toolkit of skills , I feel that I am able to provide answers to challenging questions using unique strategies . My many years of performing scientific research have helped me to become comfortable in the analysis of large , complex data sets . Indeed , as a matter of routine , I use statistical packages R Statistics and scripting languages Python , Perl , C shell to analyse and process image and simulation data . While I can work independently or as part of a team , my best achievements have resulted from taking a leading role within the multidisciplinary team of researchers . As the project lead , I like to identify and use the key competencies of the individual team members . This strategy has led to a number of successful publications . . Technologies :",
"Scientist I . . I 'm a biochemist with experience in developing native mass spectrometry , cryo electron microscopy , and cryo electron tomography techniques to study dynamic protein and protein : nucleic acid complexes . My graduate studies focused on building collision induced dissociation assays for probing conformational changes in kinase : inhibitor interactions and protein : peptide interactions . Currently , I 'm working on a cryo electron microscopy cryo electron tomography pipeline to assess heterogenous ribosome assembly intermediates . I enjoy pushing the envelope in new technologies to study systems that frustrate traditional biophysical technologies . Outside of benchwork , I am passionate about science communication and outreach .. Technologies : CryoEM",nucleic acids;peptides;proteins;interaction;structure
"Vice President . Vice President of Partnerships and Portfolio within RNA and Gene Therapies in Research Early Development , Novo Nordisk . . Vice President with more than 12 years of experience from working in the pharmaceutical industry . I have an in depth understanding of the pharmaceutical research development value chain from early target discovery and validation to handover to CMC and clinical development . I am highly experienced in applying a broad range of technology platforms to study , analyze and characterize peptide , protein and oligonucleotide based drugs for the treatment of diseases such as diabetes and obesity as well as cardiometabolic disorders . I have solid experience with project management of interdisciplinary projects and I have an excellent understanding of drug delivery technologies and physiological delivery routes . I am a very experienced leader and have a great ability for creating motivation , drive and positive energy that leads to high performing teams . I possess strong communication and presentation skills and I am highly experienced in initiating and driving collaborations with both academia and biotech external partners .. Technologies :",nucleic acids;peptides;proteins;small molecules;screening
"Team Lead , Software and Bioinformatics . Manage a group of directly reporting full time employees including senior software engineer , software engineer and bioinformatician . Lead and perform strategic planning for software development , algorithm implementation and system architecture . Responsible for hiring , performance review and task allocation . . Technically proficient professional offering extensive experience in managing interdisciplinary teams and projects . Well versed in various programming languages . Practiced in bioinformatics , software engineering and product management . Comfortable serving as team lead or individual contributor .. Technologies :",
"Bioinformatics Scientist II . R D , variant biomarker discovery and detection , algorithm development , software development . My recent experience has been focused on all stages of the product development life cycle : from early conception and biomarker identification to algorithm development and clinical validation . I excel in small and large collaborative R D teams of molecular biologists , software engineers , and statisticians . My roles often involve model development , data analysis , data management , pipeline development , and software management . Software development experience ranges from quick prototyping to late stage software design and testing following ISO standards and compliance . My passion for discovery lives alongside enabling my teams to analyze and understand their own data . Creating low barrier tools with high data accessibility expands engagement , increases development , and enhances cooperation for all team members . Relevant Skills Proficient languages : Python , R , Perl , bash , PHP , SQL Intermediate languages : Java , C , MATLAB Sequencing : QC , alignment , bisulfite sequencing Microbiome : 16S , metagenomics , annotation Automated analysis pipeline reports Multivariate statistical analysis , regression , classification Model parameter optimization , data exploration Supervised unsupervised machine learning techniques Cluster computing , AWS Prototyping and ad hoc analysis . Technologies :",
Head of R D Digital Technology in San Francisco . Lead the Digital Technology team responsible for the delivery of all Informatics IT products and services at three Pfizer R D sites in the San Francisco Bay Area . . Experienced Informatics IT leader in the biotech and pharmaceutical industry . Passionate about transforming people 's lives with innovative digital technologies .. Technologies :,
"Clinical Research Supervisor Protocol Project Manager . Pancreatic and Gastroesophageal Cancers Gastrointestinal Oncology , Helen Diller Family Comprehensive Cancer Center . I am on a mission to use my background in computational biology to make people 's lives better . It amazes me to think about the potential in applying today 's technological advances to a healthcare setting . The time I spent during my undergraduate career studying several areas of biology and the fundamentals of computer science has prepared me to tackle this challenge head on . I have been able to walk away from my four years of college with a variety of lab and analytical skills , the ability to learn quickly , and the motivation to always give my best effort . Knowing that I am making an impact on someone else 's future through my work is an exciting feeling . I am always ready to jump in to something new wherever my work takes me . When I 'm not at work , I 'm likely spending my time with my family , my turtle , or my camera . . Technologies :",
"Senior Scientist . . Highly experienced in gene to structure workflows X ray and cryo EM . Expertise in all facets of X ray crystallography . Highly experienced protein biochemist . Deep knowledge of protein structure and function . Skilled in a broad range of biochemical , spectroscopic and biophysical techniques . Track record in academic and industry based settings . Motivated leader of research and excellent team player . Superb communication skills .. Technologies : Xray;CryoEM",proteins;structure
"Senior Bioinformatician . Conduct end to end analyses of large scale data driven problems , consisting of independent research , data exploration , pipelining and visualisation , leading to actionable conclusions . Lead the design and implementation of in house packages in Python and R that are used in production and include unit tests and version control with git . Represent the bioinformatics team in cross company meetings for Microbiotica s culture collection program Communicate complex methods , analyses and results effectively in an interdisciplinary environment . . Technologies :",
"Researcher . I work as a researcher at the Department of Immunology , crystallizing a target protein involved in human health . . I 'm an experienced structural biologist focusing on the molecular basis of human disease , with a broad repertoire of methods . Key skills : X ray crystallography Protein expression and purification Membrane proteins Lipidic cubic phase crystallisation LCP Drug development Microbiology Molecular biology Surface plasmon resonance Cell biology Microbiology Antibodies Immunology Science communication . Technologies : Xray;SPR",antibodies;membrane proteins;expression;interaction;structure
"Senior Bioinformatics Scientist . . Experienced computational biologist with a demonstrated history of working in the biotechnology industry . Skilled in prokaryotic eukaryotic genomics , statistical data analysis and molecular biology . Strong research professional with a Doctor of Philosophy Ph.D. focused in Genomic Sciences Genomics from University of Liverpool . . Technologies :",
"Pre Doctoral Fellow . Detailed studies on organelle dynamics and effected metabolite pathways in gene knockout knockdown parasite will throw light on organelle associated cellular homeostasis pathways in the malaria parasite . Overall our studies will also help us to validate these candidates as new drug targets in the parasite . Expertise in culturing and subculturing adherent mammalian cell lines , transfection , cell counting , cryopreservation of cell lines . Efficient in cultivation of Plasmodium falciparum parasite cell culture and cell based immunological assay development , generation and maintenance of stable transgenic lines Molecular cloning and gene expression Experienced in protein biology purification , antibody generation , immunoblotting and Co immunoprecipitation Trained in SPR and Confocal microscopy Proficiency in training and managing laboratory technician and students Lab management and part of organizing committees of workshops and symposia Digitals skills : Microsoft office package , photoshop , ImageJ . I am an enthusiastic , hard working and dedicated individual with a strong interest in Cell Biology . Skilled research fellow with good experience of working in the biotechnology industry . Highly experienced in Mammalian Cell Culture , Parasite Cell Culture as well as Bacterial Cell Culture , Protein Expression and Purification , Immunoprecipitation , Fluorescence Microscopy , Surface Plasmon Resonance . Resilient and focused research professional with good work experience .. Technologies : SPR",
Postdoctoral Scholar Fellow . . Study on structures of pathogens and immune related molecules using single particles cryo EM .. Technologies : CryoEM,proteins;structure
"Senior computational biologist . Lead design and development of computational systems for bioinformatics analysis of sequence and protein structure for applications in bio defense . . It is my goal to apply my extensive background and training in biological research , computer science , and computational systems development and modeling to address the antibiotic resistance crisis . Specialties : pathogen biology , bioinformatics , biological modeling , protein structural informatics , technical writing and editing , team leadership https : www.researchgate.net profile Carol Zhou ev hdr xprf . Technologies :",
"Principle Scientist . Multi project research on developing and characterizing novel protein and RNA based vaccines . 15 years of research experience in fundamental biomedical research : biochemistry , biophysics and molecular biology , rational improvement of specificity of gene editing technology , fundamental research in broad areas of cell biology and immunology , innate DNA repair machinery and retro virology , antigen antibody interactions , structural and stability investigation of antigens , R D of novel analytical assays . Research excellence substantiated by 23 high impact factor publications and recognized through numerous professional awards .. Technologies :",antibodies;proteins;characterization;interaction;screening
"Cryo EM Facility Manager . . Julio Ortiz began his career in electron microscopy , under the supervision of Dr. Ra l Padr n at the Venezuelan Institute for Scientific Research IVIC . He moved to Germany where he applied cryo electron microscopy to actomyosin complexes supervised by Dr. Rasmus Schroeder in the Department of Dr. Ken Holmes Max Plank Institute for Medical Research . Turning his attention to tomography and associated techniques , Julio Ortiz went to the Max Planck Institute of Biochemistry in Martinsried for his post doctoral studies in the Dept . of Dr. Wolfgang Baumeister . He contributed to the development of an approach that proved one can obtain meaningful macromolecular structures by classifying and averaging subtomograms essentially moving single particle analysis from 2D to 3D. He presented the first ribosomal atlas of an intact cell S. melliferum . Ortiz and coworkers revealed the native 3D organization of polysomes and solved the structure of hibernating ribosomes inside intact bacterial cells . His expertise covers a broad range of techniques in cryo electron microscopy , from single particle analysis to focused ion beam micromachinery for cellular tomography . After having served at the Netherlands Centre for Electron Nanoscopy NeCEN and the Institute of Genetics and of Molecular and Cellular Biology IGBMC , and the Forschungszentrum J lich as Cryo EM facility manager , he joined Thermo Fisher Scientific as Sr . Software Product Marketing Manager .. Technologies : CryoEM",proteins;structure
"Postdoctoral Researcher . My current research focuses on the development of novel late stage C H functionalization methods to streamline the synthesis of PROTACs PROteolysis TArgeting Chimeras , using automatized HTE techniques . This work is supervised by Magnus Johansson , Johan Johansson and Stig Friis , in collaboration with Prof. Lutz Ackermann at the University of G ttingen Germany . . ORCID ID : https : orcid.org 0000 0002 9232 1236 . In 2020 , I obtained a PhD in Organic Chemistry from Imperial College London , where I worked on the Pd catalysed C sp3 H arylation of saturated N heterocycles . I am currently a Postdoctoral Fellow at AstraZeneca Sweden focusing on late stage C H functionalization strategies for PROTACs synthesis . Outside of the lab , I am passionate about travelling and reading ; I enjoy running and , of course , cooking .. Technologies :",molecular glues;developing;screening
"Research Scientist Small molecule screening for cancer drug development . . My research expertise has spanned diverse areas in biochemistry , biophysics , molecular evolution , and cancer immunotherapy . Pursuing scientific research has been enriching in several ways as in addition to science , it has trained me in project people management , public speaking , and scientific writing . Before starting my research career , I graduated with an engineering degree in food technology . During this course , I was trained in food chemistry , food microbiology , and food processing engineering . For my future career , I am seeking permanent positions as an R D scientist in the areas of protein biophysics biochemistry and science writer or editorial positions . Transferable skills : Project management People management Time management Conflict resolution Mentoring Grant Writing Science Communication Technical expertise : Protein Purification Molecular cloning Enzyme kinetics Circular dichroism spectrophotometry NMR spectroscopy MALDI mass spectrometry Isothermal Titration Calorimetry ITC Biolayer Interferometry BLI Microscale Thermophoresis MST Dynamic Light Scattering DLS SELEX Yeast surface display Instruments used : GE AKTA Basic FPLC and VARIAN RP HPLC systems Spectrophotometers from HITACHI , Applied photosystems and Biokine MALDI TOF TOF mass spectrometer from Bruker Daltonics and Agilent Technologies Bruker Avance NMR spectrometers Auto ITC and PEAQ ITC instruments from GE Octet RED , octet QK and octet Blitz instruments from ForteBio MST instrument from nanotemper , Gryphon robot for preparing crystal screens and ARI UV imager for crystal visualization Data analysis skills : Graph Pad prism and JMP In silico structural and sequence analyses ; spdbv , pymol and ccp4 , BLAST , clustal omega , T Coffee Acquisition and analysis of NMR spectra ; topspin and ccpnmr Solution of cryo EM maps using cryosparc Structure modeling and refinement using COOT and Phenix . Technologies : CryoEM;ITC;SLS DLS;BLI;MST;CD;NMR",proteins;small molecules;characterization;interaction;screening;structure
"Senior Research Software Engineer High Performance Computing . . I am a research software engineer for high performance computing for medicine , life and environmental science . Technologies :",
"Dean , College of Physical and Mathematical Sciences . The College of Physical and Mathematical Sciences CPMS at Brigham Young University houses seven departments : Chemistry Biochemistry , Computer Science , Geological Sciences , Mathematics , Mathematics Education , Physics Astronomy , and Statistics . Together , we work toward achieving our two fold mission : To provide the environment , the mentors , the tools , and the experiences in fundamental science and mathematics that students all across campus need in order to contribute in their various fields and become lifelong learners . To investigate , understand , and appreciate the beauty and complexity of the universe while enhancing reverence for its Creator . Prospective candidates and students can visit my office at N 181 Eyring Science Center ESC Mon Fri 8 am 5 pm closed for University Devotionals Forums on Tuesdays 11 am 12 pm . You can reach the office by phone at 801 422 2674 or by email at cpms byu.edu . . I m a world class elite scientist , proven scientific leader , and professor of biochemistry who is now serving as the Dean of the College of Physical and Mathematical Sciences at Brigham Young University BYU in Provo , Utah . I earned my doctorate working on electron microscopy of RNA polymerase and other protein complexes with Dr. Roger Kornberg who later won the Nobel prize for structural studies of transcription at Stanford University . I continued my work in protein electron microscopy as a Damon Runyon Walter Winchell post doctoral fellow under the supervision of Dr. Kenneth Downing at the Lawrence Berkeley National Lab . There , my interests expanded to include electron tomography of whole cells . During my 18 year career as Professor of Biology and Biophysics at the California Institute of Technology Caltech , my research focused on three main areas : the ultrastructure of small cells , the structural biology of HIV , and the further development of cryo EM technology . Together with my colleagues , I have published nearly 200 papers in these areas , most in top journals , with over 14 K citations . My lab developed a searchable tomography database and populated it with 50 K cryotomograms of over 100 different viral and microbial samples . Among my most prominent discoveries has been the structure and function of the bacterial type VI secretion system , a poison tipped spring loaded molecular dagger , and the architecture of the type IV pilus responsible for cell motility . All this work is now summarized in a free electronic textbook , the Atlas of Bacterial and Archaeal Cell Structure . In addition to my scientific work , I m passionate about teaching students about biophysical methods and mentoring up and coming scientists . I m best known by students from my popular course , Getting Started in Cryo EM , which has over 1 M hits . To date , 14 scientists I trained have gone on to become professors , and I have two decades of experience leading a lab of 15 20 scientists . In 2020 , I came to BYU to lead the College of Physical and Mathematical Sciences because of my personal faith and commitment to fostering advancement for BYU s students and faculty . I welcome contacts from prospective candidates considering working for the college , students considering BYU and the College of Physical and Mathematical Sciences , and employers interested in our students for internships or future employees . You can reach out to me here on LinkedIn or via email at Grant Jensen byu.edu .. Technologies : CryoEM",proteins;structure
Sr Computational Scientist . GATK methods development . . Technologies :,
"RnD Scientist II in Machine Learning , Health Product . . . Technologies :",
Senior Scientist . . Combining strong background in Computational Structural Biology with a cand.scient nanotech and lab training . My interest is in combining experiment and computational simulations to solve challenges in biotech . I enjoy all aspects of science communication as well as taking the lead in challenging projects .. Technologies :,
"Principal Scientist . . Committed researcher and teamplayer with a solid foundation as a mass spectrometrist and an interest in digital transformation . I have a problem focused and critical mindset and enjoy solving a challenging problem in a team . I am a skilled communicator of complex scientific results to different stakeholders , and a good multi tasker that can organize and supervise project teams to excel in a short timeframe . In recent years , I have developed my expertise within digitalization by applying data science to repetitive or laborious work tasks . During my career in pharmaceutical sciences , I have worked on and managed a wide variety of research projects both in industry and academia , amongst others : LC MS bioanalysis for early PK PD and ADME studies from plasma and tissue immunogenicity assessment of novel drug candidates by MHC associated peptide proteomics cardiac shot gun proteomics to discover new disease mechanisms affinity proteomics to identify drug targets in the brain structure activity relationship studies of protein peptide interactions using HDX MS . Technologies : SPR",
"Postdoctoral Scholar . Investigating structure property relationships for solid lipid nanoparticles LNPs with applications in gene therapy in Sahay lab Characterizing lipid membrane properties using thermal analysis , small angle X ray scattering , electron microscopy , and fluorescent assays Heading cryo electron microscopy efforts , including generating funds via grants 30k , image acquisition , processing , and 3D reconstruction Extensive experience in scientific writing paper , grants , and reviews . Analytical Chemist with broad experience in Organic , Materials , Colloidal , Polymer , and Biological chemistry . Self motivated researcher with excellent problem solving and critical thinking skills equally experienced working with a team both as a member and a supervisor .. Technologies : Xray;CryoEM",carriers;characterization;stability;structure
"Sr . Laboratory Director . Applying cryo EM to antibody epitope mapping from vaccine trials , including HIV . Protein biochemist and structural biologist in the field of HIV vaccine design . Duties include design and expression of novel immunogens in mammalian cells , stringent purification protocols for animal immunization studies , and quality control assessment of antigens alone or in presence of adjuvants buffers using a combination of biolayer interferometry , differential scanning calorimetry , isothermal titration calorimetry , and electron microscopy . Assessment includes samples from GMP level production . Additional projects involve high resolution epitope mapping and structural determination of HIV Env trimers using cryoelectron microscopy , with a focus on trimer dynamics . https : www.ncbi.nlm.nih.gov myncbi 1LypwukJvMUQ7 bibliography public . Technologies : CryoEM;ITC;DSC;BLI",antibodies;characterization;interaction;stability;structure
"Associate Director , Bioinformatics . . I am a Bioinformatics PhD with experience analyzing a variety of next generation sequencing to answer different biological questions . Sequencing has the potential to greatly advance human health and this goal comes with many challenges that I am eager to solve . Although I have a deep love for biology , I am broadly interested in the development and application of computational and statistical methods that extract meaningful information from large scale data sets . All interesting problems are welcome .. Technologies :",
Research Scholar . Working on the elucidation of the high resolution structure of apolipoprotein B 100 by cryo EM . . . Technologies : CryoEM,proteins;structure
"Bioinformatics Scientist . Computational biology to study diverse mechanisms of gene regulation . Bioinformatic studies of cell state from single cell high throughput sequencing data . . Experienced at generating discoveries through working in collaborative teams that can include synthetic chemists , virologists , structural biologists and cell biologists . Expert at methods development , computational modeling , machine learning and molecular simulation . Research activities include analysis of high throughput sequencing data or simulations to study drug resistance in infectious disease , gene regulation in cell cycle , cellular differentiation and cancer .. Technologies :",
Computational Biology Senior Software Engineer . . . Technologies :,
"Associate Director , Computational Biology . . . Technologies :",
"Director of Informatics . Head R D Systems and Data Science . Serving as an Information Technology professional for 20 years across biotechnology and pharmaceutical industries while managing decisions , design , and support of software systems and data science within research , development , pre clinical , and clinical groups . Specialties : Biotechnology Biology Chemistry . Technologies :",
"Researcher . Executing and developing cross linking mass spectrometry of protein complexes . Analytical scientist with extensive knowledge in protein mass spectrometry and structural biology , with core expertise in host pathogen interactions and antibody characterization . Key areas of expertise include a unique combination of protein biochemistry , cross linking mass spectrometry and single particle cryoEM . Ambitious , detail oriented and methodical researcher successful in developing and leading research projects and method development . Key roles in experimental research design , implementation , data analysis , data evaluation and supervision . Reliable and collaborative team player with excellent communication and problem solving skills . Academic research interest is to explore structural and molecular level mechanism of host pathogen interactions during an infection , and how pathogens use defined virulence determinants to target central components of the host s immune system . . Technologies :",antibodies;proteins;interaction;structure
"Assistant Professor . Structural biology of lysosomal membrane proteins protein complexes by single particle cryoEM cryo electron tomography . I have always been intrigued by the molecular mechanisms that drive cellular function , especially at the membranes . This led me to pursue my doctoral studies at the Max Planck Institute of Molecular Physiology in Dortmund , Germany . Following which I moved to European Molecular Biology Laboratory EMBL , where I worked towards delineating the aforementioned mechanisms in the native cellular context . I am currently heading an independent research group at the Life Sciences Institute , University of Michigan . . Technologies : CryoEM",membrane proteins;structure
Bioinformatician . . . Technologies :,
"Scientist , Machine Learning and Computational Biology . . I am presently a Computational Scientist at Tessera Therapeutics where I develop efficient algorithms and accurate machine learning models for Gene Writing and Gene Rewriting . These are a set of new biotechnologies that enables one to write therapeutic messages into the genome to alter genes and cure diseases . Prior to this , I was a graduate student with Prof. Howard Salis at Penn State University , where I trained as a Computational Synthetic Biologist . There , I developed and experimentally verified novel optimization algorithms and predictive models to engineer synthetic genetic parts , systems , and genomes with tailored design and synthesis constraints . During my PhD research , I published several papers in top tier science journals including a first author paper in Nature Biotechnology . In my free time , I enjoy Sci Fi and Horror .. Technologies :",
"Principal Scientist . Structural Biology , Protein Crystallography , Drugability Assessments , Hit to Lead Optimization and Lead Optimization , Fragment Screening . . Technologies : Xray",proteins;small molecules;screening;structure
"Senior Computational Biologist I . . Seven year experience in cancer genome sequencing data analysis with python , R , and MATLAB . I developed a cancer driver gene identification method that outperformed eight top notch cancer gene identification tools in 3 out of 4 metrics , including a 51 improvement in overlap with the known cancer genes , and a 102 improvement in consistency over the most popular tool . Expertise : 1 . Programming : Proficient in Python ; some experience with MATLAB , R ; basic knowledge of Perl , SQL 2 . Statistics and Machine learning : Parametric and nonparametric statistics ; Probability distribution ; Hypothesis testing ; Regression Linear , Logistic ; Classification KNN , Decision Tree , Random Forest ; Clustering 3 . Domain knowledge : Cancer genetics ; Oncology ; Next Generation Sequencing NGS ; Biochemistry ; Proteomics 4 . Communication : Collaborated with experimental scientists and physicians ; Teaching experience . Technologies :",
Research Intern Wendler lab . Recipient of the DAAD RISE 2022 working to solve the 3D structure of S25DH using cryo EM and optimising carbon coating for self developed EM grids . . Technologies : CryoEM,proteins;structure
"Staff Research Scientist . Cryo EM Scientist for EMBL and ESRF . I am expert in single particle electron cryo microscopy cryo EM and structural biology with a deep interdisciplinary scientific background . Currently , I am part of a team running an cryo EM facilty at ESRF and EMBL Grenoble . In the field of structural biology I specialized in cryo EM with a broad experience in different samples , microscopes and image processing tools . I am interested to link the understanding of the molecular machinery of life , and the translation of structural knowledge for pharmaceutical research application and small molecule design . . Technologies : CryoEM",proteins;small molecules;structure
"Research Development Scientist . . 12 years experience in Research Development , including 3 years in postdoctoral academic research and 10 years in industrial R D. Worked as Product Owner PO in Life Science 's technologies , As a PO , Developed new Analytical tools Sensorgram Comparison in Biacore T200 platform 21 CFR part 11 SW for Biosimilars characterization by practicing the Scrum Agile methodologies . Experienced in multidisciplinary R D including Organic Chemistry , Polymer chemistry , Antibody conjugation chemistry , Life science s technologies , Biosensors and Nanomaterial s. Experienced in New Product Development process , from feasibility to design transfer to manu facturing . Led the projects by working with various cross functional teams QA , Eng , Mfg . Skilled in Kaizen , Problem solving process , project visual management and risk management . Hands on experience in various instrumentation data analysis : i Chromatography techniques for small organic molecules large bio molecules purification ; ii Antibody binding affinity studies SPR Biacore ITC , iii Structural characterizations NMR , Mass , IR Fluorescence ; iv Nanomaterial s characterizations TGA , AFM Raman . Published 15 articles , 1 book chapter 10 conference proceedings , resulted with citations 500 h index of 12 . Specialities in R D : Organic synthesis , Bio manufacturing technologies , Antibody conjugation , Bio molecular interaction studies , Protein analytical 's , Biosensors , Nanoparticles Graphene chemistry , Polymer Chemistry , Fluorescent probes . Functional Managerial skills : Technical lead , people manager lab manager . Product owner Scrum methodology . Provided trainings to customers , presented product demo in symposiums . NPI process , Six Sigma , Scrum methodology , Kaizen , Problem solving process and Risk management . Supervised master s graduate students in various multidisciplinary research projects .. Technologies : ITC;SPR;NMR",antibodies;biologics;small molecules;interaction;structure
"Advanced Screening Scientist . . Creative scientist with 10 years experience in protein biochemistry , structural biology , assay development , high throughput screening , molecular biology , biophysics , and cell biology . Paired with a passion for science I enjoy to tackle scientific problems . This has resulted in several publications that can be accessed through my ResearchGate profile : https : www.researchgate.net profile Tobias Rumpf . Technologies :",nucleic acids;developing;screening;structure
"Director and developer of the antibody discovery platform . Developed and direct the antibody discovery platform for the Division of Immunology and Allergy at the Lausanne University Hospital CHUV in Switzerland . Research is focused on discovery of novel neutralizing antibodies to infectious diseases with fully human antibodies isolated from virus specific B cells in post infected or vaccinated donors . The antibody discovery platform combines an in depth experience and knowledge of cellular immunology , development of sensitive high throughput biochemical assays , cell based neutralization assays and virology expertise to discover the rare antibodies with best in class properties . Cryo electron microscopy has been use to determine the structures of our antibody antigen complexes at a molecular level . Anti COVID antibodies P2G3 and P5C3 , reported in Nature Microbiology and Cell Reports , display highly potent neutralizing activity against all SARS COV 2 variants of concern including Omicron BA.1 , BA.1.1 , BA.2 and are more potent than virtually all authorized or clinically advanced anti SARS CoV 2 mAbs . These antibodies bind two distinct epitopes on the viral Spike protein making it much more difficult for the virus to escape both antibodies when used in combination . Apart from identifying antibodies with potent cell culture based neutralization activity , the antibody discovery platform has strong collaborations with different groups throughout Europe for testing anti viral efficacy in animal models . We demonstrated that P2G3 alone confers complete prophylactic protection when administered to monkey prior to infection with SARS CoV 2 Omicron virus . P2G3 used in combination with P5C3 also confers excellent therapeutic efficacy in clearing virus and inhibiting active viral replication of the Omicron variant with administration of the antibody cocktail after infection of the monkeys . . . Technologies : CryoEM",antibodies;developing;screening;structure
"Bioinformatics Scientist . . Metagenomic analysis using next generation whole genome shotgun sequencing data and computational pipeline development in a Unix environment for bioinformatics applications . Development of a web application as a theoretical model for functional metagenomics analysis and metabolic reconstruction . Upstream process development experience for production of monoclonal antibodies using mammalian expression systems . Biotech operations expertise in microbial fermentation and cell culture , operating bioreactors ranging in size from 250 mL to 200 liters . Link to a list of my publications via Google Scholar list on this profile is incomplete : https : scholar.google.com citations user KygfdVgAAAAJ hl en oi ao Computing skills : Strong proficiency : Perl ; C ; SQL MySQL ; Excel VBA ; bash shell scripting Some proficiency : C ; Java ; R ; Python ; MATLAB Simulink ; Web Development using Perl CGI and HTML templates , Java based applications using Java servlets , JSP , JDBC , JavaScript Other software packages : MS Office Word , Excel , PowerPoint . Technologies :",
"Research Fellow . . I am a research fellow at the University of Birmingham , leading a semantic healthcare research group within the Gkoutos lab . I have established my own theme of research surrounding the creation and application of novel algorithms to learn from multi modal and multi contextual biomedical and clinical data . I have an honorary contract at University Hospitals Birmingham and work closely with clinicians at the Queen Elizabeth Hospital to perform research that has direct implications for patient care , such as discovery of rare disease patients unknown to specialist clinics .. Technologies :",
"Head of Scientific Computing . Currently , I am leading a team of 11 developers including a few students and STPs working in the areas of applied computing to Radiation Protection , Radiotherapy Physics , Nuclear Medicine Physics and Imaging in general . The team also develop software throughout the wider trust including a few medical devices . App development is prevalent throughout the teams portfolio as well as many projects looking at standardisation throughout healthcare and deep learning AI and decision support systems mainly with medical images . . . Technologies :",
"Senior Research Fellow . . Experienced bioinformatician with a focus on high throughput sequencing analysis in medical genomics . Strong publication record as a collaborator with world class research groups in rare diseases , population , and cancer genomics .. Technologies :",
"Associate Scientist . . Experienced Biophysicist specializing in Biopharmaceutical Purification Development . Skilled in Chromatography , Protein Biophysical Chemistry , Biochemistry , Bio analytical Characterization , Molecular Biology , Biotechnology , Cell Culture , and Computational Modeling . Strong professional background with a Doctor of Philosophy PhD focused in Biophysics from University of Wisconsin Madison .. Technologies :",biologics;proteins;characterization
"Professor of Physical Chemistry and Director , Centre for Computational Science . . . Technologies :",
". . Initially trained as a computer scientist , I went on to computational biology and eventually experimental biology as well . Areas of focus have included developing computational and experimental methods for assaying regulatory genomics , host microbiome interactions , bacterial genomics , single cell genomics , spermatogenesis , and now NK cell biology and immunotherapy .. Technologies :",
Analytical Scientist . Analytical Scientist in the Protein Analytical Chemistry PAC team . . Technologies : SPR;NMR,proteins;characterization
"Associate Product Manager Intern . AI Powered Search for Salesforce B2B Commerce . I am a UC Berkeley senior pursuing a dual degree in Electrical Engineering Computer Science and Business Administration as part of the Management , Entrepreneurship , and Technology M.E.T. program . I am currently looking for 2023 opportunities in product management , machine learning , and computational biology neuroscience . Please feel free to reach me at anacismaru berkeley.edu . Technologies :",
"Senior Researcher in Computational Chemistry . Understand through computational approach what molecular properties convey cell permeability , oral bioavailability , and target binding to drugs beyond the rule of 5 space , particularly macrocycles and PROTACs . The computational approach includes Artificial Intelligence , Biomolecular simulations , Ligand and structure based modeling , molecular properties , etc . . Experienced Computational Chemist with a demonstrated history of working in the higher education industry . Skilled in Pharmaceutical Research , Marcocyclic conformational sampling , cell permeability , Cheminformatics , ADME , PROTAC modeling and biomolecular simulations . Strong research professional with a PhD focused in Computational Medicinal Chemistry from K benhavns Universitet .. Technologies :",
"Postdoctoral Research Associate . . Following my PhD and postdoctoral positions elucidating the mechanism of the challenging membrane protein , mitochondrial complex I , I began my current position at Domainex as an assay biologist . Here I am utilising a wide wide variety of techniques to generate bespoke assays that drive developments in drug discovery and industrial science . I find assay development a highly stimulating pursuit , requiring me to solve new problems and draw from a wide knowledge and skill base every day . . Technologies : NMR",membrane proteins;small molecules;developing
"Analytical Project Lead . Global Drug Development Technical Research Development , Oberhaching , Germany . Senior analytical scientist with cross cultural working experience . Experienced in managing global technical projects in late stage biopharmaceutical development , regulatory submissions and network teams . Broad technical expertise in chromatography , mass spectrometry and biotherapeutic protein and vaccine characterization . . Technologies :",biologics;characterization
Associate Statistical Scientist . . . Technologies :,
"Vice President , Head of Computational Sciences . I lead the Computational Sciences team . Our work spans computational biology , bioinformatics , data science , and software engineering . Our responsibilities include : Developing and validating analysis pipelines for NGS assays to quantify gene editing and detect potential off target effects existing and novel off target assays , RNA seq , WGS , scWGS , etc . Supporting protein and RNA engineering efforts through phylogenetic analysis , structural modeling , protein design , and novel enzyme discovery Using computational approaches including AI ML to select optimal base editing strategies and prioritize therapeutic targets Building a robust cloud infrastructure for scientific computing Developing software to automate data management and data analysis , as well as building and maintaining databases that power Beam 's scientific efforts Supporting lab automation and LIMS development . . Technologies :",
"Director Research Fellow . . 20 years of experience in Biopharma R D Versed in drug discovery in the fields of autoimmunity and Oncology , tackling such diverse target classes as GPCR , NHR , cytokines and their receptors Extensively experienced in leading biology teams and cross disciplinary teams to deliver drug candidates Delivered six clinical candidates , both small molecule and biologic based , and enabled over 10 IND filings Served on several clinical development teams and contributed to selecting indications , designing and implementing clinical trials Established facilitated several collaborations with academic institutions , both inside and outside the US , complementing BMS ' capacity in deepening biologic understanding of diseases and targets as well as in elucidating pharmacologic modes of action of clinical candidates Recognized for his scientific accomplishments at BMS as the recipient of a Biology Leadership Award , a Technology Innovation Award , four Innovation Grant awards , and five Triumph Awards Co authored over 40 peer reviewed publications and holds three patents Trained in both Medicine and Research : M.D. Weifang Medical Univ . , China , MS Shanghai Medical Univ . PhD in Microbiology Immunology Univ . of Missouri Columbia , and postdoc Art Weiss ' lab , HHMI , UCSF . Technologies :",biologics;membrane proteins;proteins;screening
"Principal Scientist Head of Structural Chemistry . Headed the Structural Chemistry team 3 4 FTE s at two sites in support of a large portfolio of drug discovery projects comprising five therapeutic areas . Established various Biophysics methods for compound characterization and validation of target engagement e.g. by SPR , NMR , TSA . Supported all Lead Discovery efforts by implementing quantitative higher throughput assays to study small molecule behavior in solution e.g. aggregation , solubility , target engagement by NMR , DLS , HPLC . Guided the development of novel Biophysical assays focused on enhancing the understanding of the biochemistry of ubiquitin ligases and other related enzymes involved in cellular protein degradation . Assays of interest include both protein ligand and protein protein interaction techniques with focus on screening and validation novel ligands for E3 ligases , PROTACs and molecular glues by NMR , SPR , among other enabling technologies . Elucidated ternary complex formation and related structure function relations for multiple difficult to drug target proteins . Worked closely and collaboratively in multi disciplinary teams of structural and molecular biologists , medicinal chemists , and pharmacologists . Characterized small molecule ligands and degraders using Biophysics for in depth understanding of target engagement , selectivity , and mechanism of action within the induced proximity platform . Demonstrated that biophysical validation increases success of downstream technologies X ray crystallography , cryo EM , cellular assays . Implemented robust processes for high throughput analytical data generation including NMR and LC MS with automated structure verification that led to more efficient in house small molecule library design and enabled rapid QC of externally synthesized molecules . Collaborated closely with screening , compound management and separations groups in validating compound integrity , and gathered analytical data in unified databases in a fully automated fashion . . Experienced drug hunter with 20 years of successful industrial application of structure guided drug design , leading to multiple approved drugs , advanced leads development candidates . Expert in using Biophysics driven lead generation to assist the development of highly efficient drugs for novel targets including protein protein interaction and membrane proteins . Leader of Biophysics efforts within multidisciplinary teams to support early discovery of Targeted Protein Degradation drugs , including the characterization of E3 ubiquitin ligases , and the evaluation of new modalities , such as PROTACS and molecular glue degraders . Key contributor to discovery and development of drug candidates that ultimately received FDA marketing approval , including the first mutant KRAS targeted inhibitor LUMAKRAS sotorasib , multiple precision oncology drugs such as ICLUSIG ponatinib , ALUNBRIG brigatinib , EXKIVITY mobocertinib , drug eluting coronary artery stent EluNIR ridaforolimus and MRI contrast agent VASOVIST gadofosveset . Subject matter expert for molecular structure analysis of small molecules , API , drug substance and product , impurity analysis by NMR and LC MS including on natural products . Author of numerous regulatory documents CMC section supporting IND and NDA filings . Senior level scientific leader with Ph.D. in biophysical chemistry with postdoctoral studies at Columbia University in New York . Highly motivated , team oriented and goal driven group leader with strong publication record . Superior team building , experimental design , execution , analytical , and interpretive abilities . Significant project leadership experience . Managed scientists with special emphasis on teaching , scientific mentoring , and career development .. Technologies : Xray;CryoEM;SLS DLS;SPR;NMR",molecular glues;small molecules;characterization;developing;screening;structure
"Review Editor in Membrane Physiology and Membrane Biophysics . Department Pharmakologie und Toxikologie , Medizinische Fakult t. Screening and Testing compounds targeting endo lysosomal ion channels with biochemical and cell based assays on primary neurons isolated from LSDs mouse model and on neurons derived from iPSC carrying LSDs mutations generated using CrisprCas9 technology . During my scientific career , I conducted research focused on the discovery of new druggable targets and the development of pharmacological strategies to treat rare genetic diseases by using cell biology approaches and high content imaging technology Opera and Harmony from PerkinElmer . I used automated protocols to transfect cells with siRNA oligonucleotides using the Hamilton Starlet liquid handling station together with various FDA molecule libraries . . Technologies :",small molecules;interaction;screening
"PhD Candidate , McHugh Lab . Understanding the in vivo biological function of specific long non coding RNA protein complexes , and performing further studies on their structure , folding and binding . Techniques used include : Cell culture , Western and Northern Blot , qPCR , RNA Immunoprecipitation , Sucrose density ultracentrifugation , Fluorescence microscopy and micro patterining , Transmission and Cryo Electron Microscopy . I am a graduate student pursuing a PhD in Biochemistry and Molecular Biophysics at the University of California , San Diego . I am currently advised by Dr. Colleen McHugh and am working in the field of lcnRNA biology .. Technologies : CryoEM;AUC",nucleic acids;proteins;interaction
"Biophysicist PhD Candidate Research Scientist HHMI Gilliam Fellow . My work focuses on developing new biophysical techniques to study how force activated ion channels are activated by cell generated forces in live cells and its downstream functions . This imaging based approach provides important insights into the molecular and biophysical mechanisms by which these channels are endogenously activated . My findings have led to a first author publication which was also featured as one of the editor s picks in the 2019 Communication Biology Anniversary collection My research findings , academic accomplishments and a continued commitment towards being a leader in increasing diversity inclusion in the STEM fields led to being awarded the prestigious HHMI Gilliam Fellowship for Advanced Study Identified and cultivated relationships with several collaborating labs and experts within the mechanobiology and bioengineering fields . As a PhD scientist , I have developed extensive expertise in image analysis , computational microscopy and stem cell biophysics which I regularly draw upon throughout my research projects . My experience in biomedical research has led to strong project management and experimental design experience . This can be seen in the effective collaborations that I have developed across multiple institutions . I independently led teams and managed these projects across multiple stages which ultimately has led to several publications currently in submission and under review at high impact journals . I enjoy communicating my science across audiences and am passionate about outreach and working to increase the visibility of Native Americans in STEM . Feel free to connect . Technologies :",
"Senior Cryo EM Expert . . I am a structural biologist and strive to understand fundamental molecular process of life . I employ various methods , especially cryo electron microscopy to elucidate structure of biological macromolecules to understand their working , interactions and regulation ; processes that enable life . Technologies : CryoEM",proteins;interaction;structure
"Research Technician . . Experienced and knowledgeable in drug discovery , evaluation and development having worked with both small molecules and biologicals in oncology and more recently in vaccine development Extensive experience in the pharmaceutical industry and in academic research laboratories Presented oral and poster presentations at national and international oncology conferences . Co author of 24 papers including two as first author published in journals including Nature Communications , Cancer Research and Journal of Virology . ORCID iD https : orcid.org 0000 0002 3945 7708 . Technologies :",small molecules;developing
Principal Scientist . My role in the Synthetic and Medicinal Chemistry Core is to facilitate structure based drug design through techniques of X ray crystallography and CRYO electron microscopy . . . Technologies : Xray;CryoEM,proteins;small molecules;structure
Associate Bioinformatics Scientist . . I 've gained experience contributing to both academic and industry based software development projects . In prior roles I 've helped make sense of biologically relevant data ; ranging from electronic health records to single cell RNA seq reads . . Technologies :,
"Chief Scientific Officer . . Jared is passionate about the development of novel instrumentation and methods for top down proteomics and native mass spectrometry . He graduated from The University of Texas at Austin in 2013 with a Ph.D. in Analytical chemistry under supervision from Prof. Jennifer Brodbelt . During his graduate studies , Jared s efforts were broadly aimed at the development of novel tandem mass spectrometry MS MS methods for proteomics applications . Most notable was his development of 193 nm ultraviolet photodissociation UVPD for top down proteomics . As a postdoctoral researcher at the Pacific Northwest National Laboratory PNNL , Jared became an expert in Fourier transform mass spectrometry FTMS while leading development of a 21 tesla Fourier transform ion cyclotron resonance mass spectrometer FTICR MS . In 2016 , he was promoted to a senior research scientist at PNNL and led efforts to develop and apply novel FTMS instrumentation and methods to top down proteomics and native mass spectrometry . Through industrial collaborators , Jared was introduced to and began collaborating with the team at e MSion , Inc. in 2017 . This fruitful collaboration led to advances in de novo antibody structure characterization and novel approaches to the characterization of native protein complexes . Jared joined e MSion as Chief Scientific Officer in February of 2020 .. Technologies :",
"Senior Scientist Scientific data manager . . Diligent and competent professional with rich , cross functional expertise in Pharma IT and Bioinformatics Industry . Currently working with Evotec . Self motivated with result oriented approach , can rapidly identify problems , initiate change and implement effective program in challenging and diverse environment . Posses keen acumen in analyzing and understanding of Pharma and Biotech Industry requirements . Competencies range from Computational Drug discovery and analysis , Pipeline Pilot Platform and protocol development , Chemoinformatics Unix Linux Shell scripting , Computer Programming C C , High Performance Computing , Data base creation Oracle 10 g , interpretation , review and management . Knowledge of Biological tools and techniques . Designing research methods . Composing abstract , summarizing studies , writing research papers . Project lead and Mentoring in training programs . Can assure quality timely delivery in high pressure environment with strict deadlines .. Technologies :",
"Senior Research Engineer . . Anthony Anukam is a researcher with special interests in analytical chemistry ; the biochemical and thermochemical conversion of biomass ; sustainable energy and chemicals production from forest based resources , residues , and by products as well as renewable wastes ; biomass pretreatment , fractionation , and characterization using various advanced analytical instruments ; thermal energy systems combustion kinetics and process simulation ; optimization and operation of lab scale bioconversion and biorefinery plants ; and emission measurements from thermal energy systems as well as life cycle and techno economic assessments of biorefinery technologies . As part of his research activities , he operates and interprets data from a variety of cutting edge analytical techniques such as chromatographic techniques GC , LC , HPLC , GPC ; spectroscopic techniques FTIR , Raman , NMR ; thermal techniques TGA , DSC , DTA ; electron microscopy SEM , TEM , Cryo EM ; etc . His research activities also incorporate data analysis with modeling and process simulations of different energy systems . As a certified higher education teacher , Anthony has taught a variety of courses at different higher education institutions in Africa and Europe with diverse cultural backgrounds . Some of the courses he has taught include general chemistry , analytical chemistry , environmental chemistry , physical chemistry , and combustion chemistry .. Technologies : CryoEM;DSC;NMR",
"Director , Novartis Leading Scientist , Hit Generation Science . Leading a team of scientists in MedChem , Peptide Discovery , and DNA encoded chemistry for projects across multiple disease areas . Scientific leadership for scouting , implementing and driving new lead generation approaches . . Contribute to strategy vision for hit generation science in the areas of difficult targets , library science encoded library technologies . . MedChem lead for two external research collaborations on multiple targets from various disease areas . Key projects . Establishing and driving peptide discovery platform projects . Leadership of the Novartis Peptidream collaboration driving several research targets . Leading the Novartis Nuevolution collaboration internalizing DNA encoded library technologies . MIT collaboration on segmented flow technology for MedChem . More than 20 years of drug discovery experience in a pharmaceutical company . 10 years of leadership experience at director level building groups and nurturing talents . Strong background in small molecule medicinal chemistry , lead discovery and peptide chemistry . Solid international network in industry and academia and recognized in scientific community . Excellent analytical capabilities and very effective under time deadline pressure . Ability to operate effectively in local global teams and across multiple disease areas . Successful leadership of several external collaborations . Expertise : . Drug Discovery MedChem . DNA encoded libraries ribisomal display technology Peptidream technology . Discovery of leads for difficult targets , e. g. protein protein interaction . Novel approaches to inhibit kinases . Fragment Based Drug Discovery . Flow chemistry platform for MedChem . Peptide medicinal chemistry . Antibody Drug Conjugates ADC . Scout evaluate external technologies . Implemetation of new technologies . Technologies : NMR",peptides;proteins;small molecules;interaction;screening
"Professor of Health Informatics . . The aim of my scientific research is to introduce verifiable process models into complex scientific applications . Provenance data , executable artifacts , and semi structured adaptive workflows are just some of the aspects that share the same theoretic apparatus , and can be connected into multi level process models . This effort spans multiple areas , from process algebras and formal verification , to provenance graphs , and benefits multiple application domains from clinical trials and Electronic Health Record population studies via bioinformatics to business process modelling and organisational workflows . Publications available at : https : sites.google.com site vasacurcin publications . Technologies :",
Senior Scientist Antibody Discovery . . . Technologies :,
"Undergraduate Researcher . Leveraged my knowledge of Python to create a program to compare imputed datasets with whole genome sequences to analyze TOPMed imputation panel diversity and accuracy Curated genomic datasets using Plink to filter out single nucleotide polymorphisms to prepare clean datapoints for genome imputation Implemented use of USC s high performance computing cluster to efficiently compile metadata by running scripts , managing data , and sharing results with group members . I am a fourth year student in the undergraduate Quantitative Biology program at USC and have been accepted into the QBIO progressive masters program . I have a specific interest and background in genetics . Through my undergraduate studies and extracurricular activities I have developed and honed my research and programming skills as well as expanded my knowledge of biology . My studies in the Quantitative Biology program have allowed me to explore and understand the field of genetics through computational data analysis and the importance of each singular nucleotide in our DNA . My coursework in upper level QBIO and Computer science classes have been especially helpful in blending the programming skills C , R and Python with the life science classes at the backbone of my studies . I am currently working in Dr. Charleston Chiang s lab at the USC Center for Genetic Epidemiology with a team to analyze the accuracy of genome sequence imputation in populations not heavily represented in reference panels , working directly with the Linux command line to run analyses of sequence datasets . Through various projects and coursework , I have really found a passion for genetics that I am eager to bring into the workforce .. Technologies :",
"Professor . . Principal Investigator with strong leadership skills , project management and a solid scientific background . High success rate Troubleshooter Loyal Extensive international network Currently handle 16 different active research projects . Managing a research group of 8 12 persons for 10 years Supervision , project management , data analysis . Ability to ask the right questions , both for initiating projects and for helping others bringing their projects further . Key objectives in LolandLab : Elucidation of structure function relationships in membrane proteins ; assessment of ligand binding sites , identification of protein conformational changes during activity , visualization of protien structure . Research Methods : Biophysics Fluorescence , FRET , tmFRET , x ray crystalization , Hydrogen Deuterium exchange MS , molecular pharmacology and biology , biochemistry , protein expression purification . Received two prestigious awards from the Danish Council for Independent Research : Young Elite Researcher Prize 2005 , Sapere Aude Research Leader award 2012 Published 67 peer reviewed research papers and 1 patent application , including publications in Nature Neuroscience , Nature Communications , Science Advances , PNAS , JACS , Nature Methods , Biol Psych , JCI and 10 papers in Journal of Biological Chemistry . H factor : 24 , 2300 citations . Participated in 30 international conferences ; all with a scientific presentation as invited or selected speaker or with poster presentation . Member of the International Transmembrane Transporter Society executive committee . Board member in Integrative Structural Biology at University of Copenhagen .. Technologies : Xray;FRET",membrane proteins;structure;characterization;interaction
"Researcher . IBPC UPR 9080 CNRS Laboratoire de Biochimie Th orique Modeling Ligand Gated Ion Channels nicotinic , GABA and P2X receptors activation mechanism with homology modeling and normal mode analysis ; Study of the binding of ligands docking ; study of pathological mutations related to epilepsy and myasthenia . . Modeling of protein structure function relationships including allostery . Current focus on the gating mechanism of ligand gated ion channels nicotinic , GABA and P2X receptors . Analysis of the effect of mutations and effect of ligands including drugs . Specialties : Homology Modeling , Docking , Normal Mode Analysis , Molecular Dynamics .. Technologies : Xray;CryoEM",membrane proteins;interaction;structure
". . I have been involved with various projects that revolve around enzymes involved in antiviral defense systems . My 6 years experience with protein purification , X ray crystallography and UPLC MS have led me to discover novel small molecules and deduce structures of several proteins especially those involved in antiphage and antiviral immune responses . Understanding such defense systems could help design drugs that target viral and antiviral enzymes with better efficacy . My extensive biochemical , kinetic and structural studies on oxygen sensitive enzymes , nucleotidyltransferases , nucleases , NAD hydrolases and others led me to publish my works in a peer reviewed journals . These include our recent work on an antiphage defense systems has been published in Nature Communications . I have previously worked with antiviral Radical SAM enzymes which led me to publish my manuscript in another peer reviewed journal . I am currently working on two more manuscripts that revolves around analyzing higher order protein structures and undergoing training for Cryo TEM which would be useful tool for further structural studies . I am actively seeking opportunities in structural biology and biochemistry . Given my background in X ray crystallography , protein biochemistry and cryo EM along with my ability to troubleshoot critical problems and multitasking , I believe I would be a good fit for the same . I have also been actively involved with teaching undergraduate and graduate students throughout my graduate career .. Technologies : Xray;CryoEM",enzymes;small molecules;structure
"Senior Bioinformatician . Leading the development of a bioinformatics capability within Fera and to provide bioinformatics analysis and support for projects using Next Generation Sequencing technology . Development of methods and approaches for analysing NGS data , in particular for DNA meta barcoding data , and contribution to scientific papers and project reports . I am working within the Detection and Surveillance Technologies Team , which undertakes research on the detection , identification and characterisation of both harmful and beneficial organisms in the agricultural and natural environment . Using state of the art molecular biology techniques , the team develops methods to detect pathogens and profile the diversity of organisms in a wide range of sample types , including plants , food , soil and water , and is at the forefront of adapting these techniques for use in the field . The team also undertakes research on the biology of bacteria , viruses and fungi that pose a risk to agriculture , embracing new and emerging genomic technologies as well as more traditional microbiological skills . . . Technologies :",
"Scientific Data Manager . Management of marine scientific data at the UK Polar Data Centre , British Antarctic Survey . Scientific project coordination and data knowledge management , user support and training , research operations support , leveraging interdisciplinary research experience . Specialties : marine environment data , data standards and integration , bioinformatics , genomics , molecular biology . . Technologies :",
"Associate Principal Bioinformatician . . I am a believer in the power of big data and am interested in using data science to tackle some of society 's most complicated problems . I am a bioinformatician by training and my primary research interests center on developing models and techniques to effectively leverage large scale genomic data to advance the frontiers of personalized medicine , particularly in oncology . . Technologies :",
"Group Leader , Computational Biology . . I currently hold a full time position within the Methods Group in the Data Sciences Platform at the Broad Institute , as well as affiliate status in Michael Talkowski 's lab at Massachusetts General Hospital . I am technical lead of the Genome Analysis Toolkit Structural Variation GATK SV discovery pipeline and supervise an interdisciplinary team of computational biologists , software engineers , and academic trainees across the two institutions . I oversee structural variant call set generation for large scale whole genome sequencing WGS projects including the Genome Aggregation Database gnomAD and All of Us . My responsibilities also include developing scalable and robust tools , machine learning models , and cloud based pipelines for genomic analyses . I previously developed the GATK PathSeq pipeline for pathogen detection and discovery using deep WGS and RNA seq in collaboration with Matthew Meyerson 's lab at Dana Farber .. Technologies :",
"Principal Scientist Computational Biology . . I am a creative scientist and engineer with a highly cross disciplinary education and research background , combining systems biology and bioinformatics with synthetic biology , molecular physiology and metabolic engineering . I currently work as a Computational Biologist in the Data Science group at Sonata Therapeutics formerly Inzen where I apply , develop , and biologically interpret NGS omics data analyses e.g. proteomics , RNA Seq to further Drug Discovery Development around Sonata 's platform and programs e.g. in immuno oncology . Previously I worked in the Computational Biology Group of Biogen in support of translational drug discovery in neurodegenerative diseases and biotherapeutic protein manufacturing development . I obtained my PhD in Chemical Biological Engineering from the University of Colorado Boulder where I combined Genetic Genomic tools targeted genome recombineering , Next Gen Sequencing with Systems Biology tools metabolic flux growth kinetics modeling to improve the application and design of directed evolution mutant library selections and obtain superior microbial strains for conversion of cellulosic sugars to bioproducts . Before that I worked in industrial biotechnology across R D departments genetics , bioprocess engineering , bioinformatics group , first as an MS intern and later as an Assistant Bioinformatics Scientist at DSM N.V. Delft , Netherlands . During my 15 years of research experience in biotechnology I have worked behind the computer dry lab as well as at the bench wet lab doing molecular biology on a variety of organisms : from human disease mechanisms and mammalian cell lines at Biogen , Sonata , to E.coli PhD in Colorado , Penicillium DSM and Yeast MS BS at TU Delft . Specific scientific interests in Computational Biology , Genomics , Systems Biology , Multivariate Statistics , Synthetic Biology , Metabolic Engineering , Bioinformatics , Molecular Biology , Drug Discovery and Development , Bioprocess Engineering . General interests in Data Science , Business Development in Biotechnology , Renewable Energy , and Intellectual Property .. Technologies :",
Project Scientist . Member of the Computational Crystallography Initiative http : cci.lbl.gov . Pursuing a career in structural and computational biology . Full publication list : http : cci.lbl.gov publications aaron brewster.html . Technologies :,
Lecturer in Healthcare Sciences . . . Technologies :,
"Ph.D. Student in Molecular Life Sciences . . Technical Skills Proficient in Molecular cloning in prokaryotes Lambda red recombineering , CRISPR cas9 genetic engineering Mammalian cell culturing Western Blot , SDS PAGE , agarose gel electrophoresis Fluorescence , confocal microscopy Protein purification IMAC , Size exclusion chromatography DNA , RNA , protein extraction and purification from bacteria , Zebrafish embryos , yeast In vitro transcription and translation PCR colony PCR , RT PCR Bioinformatics : Designing CRISPR targets gene knockout , NGS data analysis Handling Vertebrate Automated Screening Technology Handling zebrafish as a model system Husbandry , Fin amputation , Imaging , genotyping Handling plate reader fluorescence and absorbance Library preparation for next generation sequencing NGS and analyzing NGS data Stopped flow and quench flow Rapid kinetics techniques High Performance Liquid Chromatography HPLC Processing and analyzing small angle X ray scattering data and cryo Electron Microscopy data Circular dichroism CD spectroscopy Familiar with Gas chromatography GC , High performance liquid chromatography . ImageJ , Cell profiler Image analysis . . Operation of liquid handling robot Nimbus , Hamilton Publications : 1 Abdalaal H , Pundir S , Ge X , Sanyal S , N svall J. Collateral Toxicity Limits the Evolution of Bacterial Release Factor 2 toward Total Omnipotence . Mol Biol Evol . 2020 Oct 1;37 10 : 2918 2930 . doi : 10.1093 molbev msaa129 . PMID : 32437534 ; PMCID : PMC7530605 . : shared first author 2 Pundir S , Ge X , Sanyal S. GGQ methylation enhances both speed and accuracy of stop codon recognition by bacterial class I release factors . J Biol Chem . 2021 Jan Jun;296:100681 . doi : 10.1016 j.jbc.2021.100681 . Epub 2021 Apr 20 . PMID : 33887323 ; PMCID : PMC8131318 .. Technologies : Xray;CryoEM;CD",
Scientist . . . Technologies :,
"Phyre2 Scientific Advisory Board Memeber . . Having to step back from leading a team of 17 people in a structural biology setting , supporting small molecule drug discovery , due to illness I now spend my time managing projects and writing proposals . I recently aided in the industrialisation of the XChem X ray fragment screening hosted at Diamond Light source for rapid identification of new starting points for drug discovery . This is now a routine process in action . http : www . diamond . ac . uk industry Case Studies Case Study Fragments . html . I am currently a member of the scientific advisory board for the Phyre2 software suite . A system for structure prediction and also mutation analysis . . Technologies : Xray;NMR",small molecules;interaction;structure
"PHD Researcher . Biophysical characterization of biomolecules with solution and solid state NMR , X ray crystallography and Cryo EM . . Technologies : Xray;CryoEM;NMR",peptides;characterization;structure
"Associate Professor . . I am an associate professor and group leader with strong interdisciplinary background in biology , chemistry , biophysics and nanoscience and expertise in investigation of membrane proteins as well as interface of nanomaterials with biological samples . Through my career , I have measured the strong impact and numerous benefits of collaborative projects and networks to bring my research activities at a predominant international position . This has been achieved by building of long term national and international collaborations with both academic and industrial partners My research Group exploits novel nanomaterials for the development of several types of biosensors : 1 in cell biosensors suitable for the fundamental investigation of membrane protein signalling and the establishment of novel generation of cellular assays for drug discovery ; 2 2D and 3D protein arrays suitable for bioanalytics , proteomics and diagnostics . These novel tools are exploited for the investigation of membrane proteins in vitro and in cells . http : nano.ku.dk english research Nanobio martinez group . Technologies :",membrane proteins;characterization
"Senior Scientist in CMC Cell Therapy . . Experienced Quality Expert in ATMP with a demonstrated history of working in the pharmaceuticals industry . Knowledge within GMP for Advanced Therapy Medical Products . Skilled in cell biology , in vitro assays , monoclonal antibodies , Identifying mechanism of action of mAb drug candidates , FACS , ELISA , high through put potency and efficacy screening assays and Cancer Research . Strong quality assurance professional and QP delegate with a PhD in Medical science from University of Copenhagen .. Technologies :",antibodies;quality
"Principal Scientist . . Extensive experience in computational modeling and simulations , with emphasis in biological systems . Significant experience in computer programming and algorithm development , with a focus on data analysis and visualization tools for computational biology applications . I am a highly motivated scientist with excellent bilingual verbal and written communication skills , the ability to work in a highly collaborative and intellectually challenging environment , and the ability to learn new skills rapidly . I have a strong interest in developing and applying new methods to assist biomedical research through computational data analysis . My goal is to contribute to the design of new treatments for major diseases . Technologies :",
"Scientist , Computational Biology . . I am a computational scientist at Immunitas Therapeutics where I apply computational and statistical methods to single cell RNA seq and spatial transcriptomics data in order to discover new immunotherapies for challenging cancers . I received my Ph.D. in computer sciences from the University of Wisconsin Madison in 2019 and then went on to complete a Postdoctoral Fellowship at the Morgridge Institute for Research in Madison , Wisconsin . In my academic life , I researched and developed new computational and statistical methods for extracting the untapped knowledge contained in large , heterogeneous biomedical datasets in order to address outstanding questions in cell biology , human health , and disease .. Technologies :",
"Research Engineer at Institut Pasteur . Developing cryo CLEM and in situ cellular Cryo tomography workflow . I am a specialist in cell biology and electron microscopy with a Ph.D. in Microbiology by Federal University of Rio de Janeiro with a post doc in cell biology and ultrastructure of protozoan parasites at the same university using conventional EM and cryo EM sample preparation high pressure freezing and freeze substitution associated with 3D techniques FIB SEM slice and view and tomography serial sectioning . In 2015 I joined the Brazilian Center for Research in Physics CBPF for 10months in a post doc in the intracellular traffic of nanoparticles of iron oxide and nanostructured hydroxyapatite in mammalian cells , using the FIB SEM slice and view and lamellae preparation techniques in a 3D approach . In 2016 I joined the Philippe Bastin group to study Trypanosoma brucei intraflagellar transport using conventional EM , cryo techniques HPF and FS , and 3D approach FIB SEM slice and view and Amira software associated with fluorescence live cell imaging and basic molecular biology and biochemistry techniques . Since 2019 I am a Research Engineer at Institut Pasteur , developing the Cryo CLEM workflow and Cryo Tomography using photopatterning and cryo lamellae preparation for different biological systems . . Technologies : CryoEM",structure
"Senior Scientist . . I m a research scientist with a broad experience in protein biochemistry . During my academic and industry career I ve worked extensively with protein stability , purification , and nanostructure interactions . I always seek to expand my skillset and for the last few years I ve used programming to solve both small , repetitive data handling tasks as well as more advanced data fitting and analysis automation .. Technologies :",proteins;interaction;stability
"Senior Research Scientist PROTACs degrader drugs . Cell assay development and profiling of PROTAC protein degraders : Endogenous protein turnover studies proteomics , complex phenotypic readouts imaging , degradation assays . Project scoping in early drug development . . Fascinated by biology and the power of mass spectrometry . Expertise in cell biology , protein biology degradation PROTACs , chemo proteomics , interpretation of complex data as well as pharmaceutical drug development . Enjoying strategic design of cutting edge and collaborative research .. Technologies :",molecular glues;developing
"Scientist . Scientist . Next generation synchrotron X ray facilities such as NSLS II will yield data thousands of times more rapidly than existing X ray facilities . To exploit this capability , we must vastly improve the speed and precision of specimen preparation . To this end , I am exploring acoustic droplet ejection ADE technologies to exploit protein crystals for high throughput applications such as fragment based drug discovery and time resolved crystallography .. Technologies : Xray",screening;structure
Associate Professor of Health Informatics and Computer Science . . . Technologies :,
"Sequencing service lab head , Genetics Genomics . . I am a creative interdisciplinary life scientist with extensive experience in molecular cell biology , small molecules discovery and in depth expertise in high throughput sequencing . I am often described as an enthusiastic and efficient person with great integrity who is highly focused on results and innovation to demonstrate technology feasibility and implementation .. Technologies : SPR",
"Senior Director , Computational Sciences and Engineering . Lead development of analysis and software engineering for Inscripta 's DNA editing technologies . Includes architecting computational systems , design and development of analytical algorithms and pipelines , software design processes , and team management . . Currently , I lead development of computational systems and analyses for DNA editing technologies at Inscripta . Previously , I developed micro services systems and algorithms to analyze machine metadata from installed Dell EMC products . I have lead and performed bioinformatic analysis , statistical analysis and mathematical modeling of data for fetal diagnostics . I was a faculty member in computer science with research interests in bioinformatics , data mining , text mining and high performance computing . I have a broad computer science background , with experience in human computer interaction , computational algebra , collaborative computing in addition to my research interests . I was involved in SeWHiP , a consortium for building high performance computing infrastructure in Southeast Wisconsin to assist with the research goals of the academic community in the region . Specialties : data science , bioinformatics , data mining , text mining , machine learning , artificial intelligence , statistics , symbolic computation , high performance computing , algorithms Resume : http : craig.jasna struble.net static strublecaresume.pdf . Technologies :",
"Associate Director , Bioinformatics Lead . . . Technologies :",
"PHD Fellow . PhD Fellow in the group of Professor Thomas Frimurer Computational Chemistry Molecular Pharmacology Group Computational Chemistry Unit Have a look at our platform We are involved in multiple collaborative probe drug discovery projects and are interested in more We specialize in structure and ligand based drug design for GPCRs . https : cbmr.ku.dk researchfacilities ccu . PhD Fellow in Computational Chemistry Molecular Pharmacology at the Frimurer Group , located at the Center For Basic Metabolic Research University of Copenhagen Hi My name is David , I 'm a drug discovery scientist with bench level experience across a variety of chemistry sub fields medicinal chemistry , process chemistry , and chemical biology . My primary background revolves around synthetic organic chemistry , but I am always looking to integrate my skill set into new areas of science and support teams with what I know . I 've had the privilege of working with promising therapeutic discovery modalities such as nuerodegenerative phenotypic screening at Yumanity Therapeutics , novel lab to plant flow chemistry development at Snapdragon Chemistry , as well as exploring cutting edge target ID deconvolution tools in the Chemical Biology Proteomics department at AstraZeneca . Recently , I 've taken great interest in computational approaches to towards life sciences , based on my experience in the Computational Medicinal Chemistry department at AstraZeneca , where I utilized a reinforcement learning based de novo design platform towards the optimization of kinase inhibitors . Most recently , I have begun my PhD at the University of Copenhagen , as a member of the Copenhagen Bioscience Programme . I 'm always on the look out for interesting approaches to drug discovery , please feel free to reach out with your newest publications , reviews , blogs , or where ever else the latest news is being disseminated . Technologies :",molecular glues;membrane proteins;developing;structure
Senior Research Fellow . . . Technologies :,
Senior Scientist Lab Head . X ray crystallography and cryo EM . Publications : https : www.ncbi.nlm.nih.gov pubmed term ulrich 2C alexander . Technologies : Xray;CryoEM,structure
"Expert Scientist on Rotation at gRED . . 20 years of broad and solid hands on experience in Academia , Biotechnology and early late phase Product development and Project Management in the Biotechnology and Pharmaceutical Industry Novartis , ROCHE . Entrepreneurial mindset as demonstrated by co founding of the Anglo Japanese Biotechnology Company IC Vec Ltd. Documented track record in leading cutting edge projects , innovation patents publications 30 and drug development in early and late phase for NCE and NBEs , technology transfer to CRO CMO . Acknowledged expert skills in nucleic acid based medicines siRNA , ASO , mRNA including Lipid Nanoparticle LNP delivery approaches , and advanced analytics for the characterization of macromolecules and LNPs e. g. CLINAM panelist together with experts from Moderna , BioNTech etc . on the future of mRNA based therapeutics , TIDES speaker invitee . Industry recognized innovator NVS Leading Scientist Award and strategic thinker . Excellent soft skills , as demonstrated leadership in a matrix organization to shape next generation nucleic acid based medicines at ROCHE . Analytical thinker with an excellent eye for the essential tasks . Prefers to work in a people oriented , scientific , dynamic and innovative environment . . Technologies :",carriers;nucleic acids;characterization
"Computational Biologist III . . Computational biologist at Calico Labs , developing tools for single cell analysis and regulatory genomics . Ph . D trained in Christina Leslie s at Weill Cornell , developing machine learning models to study complex biological systems . Highlights : Computational Biology : transcription factor binding site prediction , drug sensitivity prediction , single cell RNA ATAC analysis , next generation sequencing analysis . Machine Learning : CNN , generalized linear models , multitask learning , word embedding . My website : https : hy395.github.io . Technologies :",
Scientist Bioinformatics . . . Technologies :,
"Research Intern . . My research interests involve the study of biomolecules especially protein protein interactions , lipid membrane interfaces using various computational approaches . I am also interested in bioinformatics , data science , computational structural biology and drug discovery .. Technologies :",
"Research Internship . Characterization of translational inhibitors using biochemical techniques and carrying out disome assays for preparing samples in the quest to decipher the mechanism of action using cryo EM . I am interested in structural , biochemical and molecular biology . In my field , I have had the experience to work on disome assays using a bicistronic template in the quest to decipher the precise mechanism of action of drugs . Therefore , in my Masters , I characterized translational inhibitors biochemically , an exciting part of my career in our quest to combat bacterial resistance . I have had the opportunity to conduct collaborative research in Germany , at the University of Hamburg working on drug discovery project to elucidate the mechanism of action of potent inhibitors . Having amassed skills in sucrose gradient fractionation of ribosomes , the experience has broadened my scientific growth in science and utilizing different experimental techniques for cryo EM preparation .. Technologies : CryoEM",proteins;small molecules;screening;structure
"Senior Scientist , Panel Development . . Highly skilled professional with diverse experience in the biotechnology industry . Over 10 years experience in small molecule drug discovery ADME : cell culture techniques , cell based radiolabeled assays , in vitro metabolism , and analysis using HPLC and LC MS MS . Background includes experience with assay development , quality management , ISO certification process and internal auditing , QC methods development , product development , acceptance testing , document control , and design control .. Technologies :",
"Research Chemist . . Experienced synthetic medicinal chemist . PhD , 32 step alkaloid synthesis . Postdocs include a 24 step polyketide synthesis . After transitioning to drug development in 2009 was heavily involved identifying and progressing DNDI 0690 to phase 1 clinical trials by synthesizing over 160 compounds over two year period . Currently designing and synthesizing various inhibitors and proteolysis targeting chimeras PROTACs for the Helmholtz Zentrum in Munich . . Technologies :",molecular glues;developing
Senior Scientist . . . Technologies :,
"Postdoctoral Fellow . Lipid effects on the voltage gated potassium channels . Structural and functional study of the macromolecular complexes by Cryo Electron Microscopy . Proficient with electrophysiological techniques : studying the lipid effect on the ion channels through patch clamp recording and planar lipid bilayer recording Proficient with structural biology : resolving the structure of macromolecular complexes by electron Cryo microscopy , single particle analysis and 3D reconstruction Combined multiple methods calcium imaging , capacitance measurement and carbon fiber electrode recording to investigate neurotransmitter release . Familiar with membrane protein expression and purification Experienced with molecular cloning , FPLC , PAGE , western blot , cell culture . Technologies : CryoEM",membrane proteins;structure
"Physical Biochemistry Intern . Protein structure characterization via cryo EM including map and model building , refinement , and analysis . I am a PhD candidate training in biophysics . Specifically , I 'm interested in using cryo EM to study bacterial host phage interactions at the molecular level . During my training , I hope to better understand workflows and structure determination by cryo EM . In my previous research experience at NEIU , I used serial femtosecond x ray crystallography to study a red light photoreceptor , called bacteriophytochrome , from the soil bacteria Stigmatella aurantiaca . During this time I conducted experiments at Argonne National Laboratory Lemont , Illinois , SLAC National Accelerator Laboratory Menlo Park , California , and the Spring 8 Angstrom Compact free electron Laser Hyogo , Japan . My purpose is to build my scientific toolbox in order to better understand processes at the molecular and cellular level .. Technologies : Xray;CryoEM",proteins;interaction;structure
"Research Scientist . Biochemist and Structural biologist . My research focuses on the study of molecular mechanisms involved in replication and pathogenesis of RNA viruses . Specifically , I use X ray crystallography and cryo electron microscopy in conjunction with RNA engineering to understand the structure and function of viral RNA elements in the context of virus infection . . . Technologies : Xray;CryoEM",nucleic acids;developing;structure
"Field Application Scientist III . Working as an integral member of the Biopharma Team providing technical expertise to the Bio Rad sales organization and customers in the field . As a Biopharma Field Application Scientist , I serve as a critical liaison between Bio Rad and biopharma research customers , providing pre and post sale training and application support on our Proteomics portfolio of Next Generation Chromatography NGC , Western Blotting , Gel and Blot Imagers , and Bioplex instrumentation . I closely work with Field Sales Representatives and deliver trainings , presentations , product demonstrations and technical seminars to individuals and groups with diverse needs and experience levels . Primary Responsibilities : 1 . Live demonstration of our Proteomics portfolio instrumentation , software and consumables . 2 . Provide training on and assistance with data analysis , troubleshooting , and optimization for each of these technologies . 3 . Assist customers with experimental design , assay design , and reporting of results . . Life Sciences , Biotechnology R D Professional , MBA Candidate with extensive experience in managing projects , people , and operations in laboratory environments . Seeking a position to fully utilize steeped scientific background and merge with an MBA curriculum focused on Marketing and Strategy . Scientific Specialties : Assay Development , Virology , Immunology , Cancer Biology Research , Experiment Design in Life Science Molecular Biology , Biochemistry , Cell Biology , High Consequence Pathogens SARS CoV 2 , Ebola , Zika , Flu Specialties : Marketing , Strategy , Scientific Research , Data Analysis , Marketing Research , Project Management , Process Improvement , Product Development , Business Development Leadership : Team Building , Cross Functional Collaboration , Organizational Communications , Presentations Winner : Nano start up business plan competition with Latona Therapeutics , organized by the National Institute of Health and the Center of Advancing Innovation Technologies : MS Office Suite , Advanced Excel , R , Adobe Suite , Google Suite , GraphPad Prism , Tableau Languages : English Fluent , Hindi Fluent Bengali Native Please feel free to reach out to me at : nilanjan.mpb gmail.com . Technologies :",
"Research scientist . Study of viruses using cryo electron microscopy , X ray crystallography , and biochemical methods . Michael Rossmann lab . . . Technologies : Xray;CryoEM",proteins;structure
"Senior Formulation Scientist . . I am an ambitious person who takes pride in succeeding in small as well as large tasks . My main area of expertise lies within protein stability and formulation and manufacturing of pharmaceuticals , food supplements and medical devices . More specifically , I have a PhD with focus on protein fibrillation and how proteins are stabilized by different plant extracts . During my PhD I obtained experience using fluorescence based plate reader assays , HPLC , SEC , DSC , ITC , CE , CD and FTIR as well as experimental design , analytical problem solving and scientific writing . Through my current position as product development scientist at Bifodan I have gained experience with GMP , project and stakeholder management , formulation of new and innovative dosage forms , acquisition and setup of new equipment , raw material characterization , process development , upscaling , change control , stability studies , preparation of technical and regulatory documents as well as insight in B2B sales , pricing and product launches . Last but not least , I recently concluded the education of occupational safety and a GMP course .. Technologies : ITC;DSC",biologics;characterization;formulation;stability
"Senior Scientist . Leading a team with direct reports to manage multiple projects including designing and development along with conjugation , scale up , and transfer . Managing the development of QC , in process , and external controls for various products to the scale per CLSI guidelines . Responsible for designing of crucial V V studies per regulatory guidelines . Working cross departmentally to solve production and manufacturing problems by implementing conventional scientific knowledge to unconventional use thus significantly reducing the COGS . Managed outsourced antibody development and characterization while working with the vendors . . Driven professional with excellent scientific acumen and proven track record in the areas of Immunoassays , In Vitro Diagnostics IVD , and Bioassays towards New Product Development NPD within GLP and cGMP industrial , academic , clinical , and mixed environments . Up for a role involving leading and managing people towards solving scientific and business challenges . o Expert in leading scientific teams through supervision , mentorship , and motivation resulting in successful translation of concepts to products o Established in planning and managing the project phases from feasibility to development along with V V , scale up , and transfer o Strong Knowledge of FDA CE mark CLSI regulatory processes and associated compliance documentation o Hands on with Phase Gating and Design Control for new projects along with progress tracking , milestone delivery , and budgeting o Excellent understanding of Product life cycle that allows me to lead derisking via effective risk and gap analysis o Possess strong data analysis , troubleshooting problem solving CAPA , RCA skills o Expertise in managing multi partner collaborative interdisciplinary projects from Class I IVD medical devices including point of cares POCs to Class III high throughput multiplexed IVDs o Expert in cross departmental functioning due to strong interdisciplinarity in my training o Serving as a KOL in Immunoassay designing , development , verification , and validation o Engaged with market analysis industry o Excellent command on biological , chemical , physical , and engineering designing concepts o Expert in Point of care POC device prototyping and development including microfluidic Lab on a Chip and chromatographic Lateral Flow tools o Over 15 years of experience designing and developing direct and indirect Immunoassays in ELISA , Fluorescence FIA , Electrochemiluminescence ECL , Chemiluminescence CIA formats o Skilled in bioanalytical method development using Monoclonal , Polyclonal and other affinity reagents for the detection of low abundance soluble and surface protein biomarkers , DNA , glycans , small molecules , cytokines , and growth factors o Hands on with sophisticated tools like MSD , Protein Simple , BIAcore and techniques like bioconjugation , cell based bioassays , Anti Drug Antibody Assays ADAs , nano micro material designing and synthesis . Technologies :",antibodies;biologics;characterization;developing;screening
"Associate Director , QA GMP . Antibody Drug Development QP Delegate Lead Auditor CMO , Quality Agreements Driving Changes , Stakeholder and CMO Management Cell Bank , Biological Intermediate , Drug Substance , Drug Product Review and Release IMP Certification to Clinical Trials Comparators and AMP PPQ QC , Method Qualification , OOS , Stability Expiry . Educated pharmacist M.Sc . in Pharmacy and GMP and ISO 9001 lead auditor with leadership skills and solid QA experience from working in Denmark and abroad . Experience in clinical and commercial manufacturing DS , DP , IMP and product release , process validation , facility and equipment qualification , and projects including tech transfer of new products from clinical to commercial manufacturing . Strong quality mindset and ability to work in and with Quality Management Systems . Key words : QP , cGMP , quality management system , change control , document control , CMO , lead auditor , deviations handling , validation , inspections .. Technologies :",antibodies;quality;stability
"Research Investigator . Artificial intelligence , Machine learning , Computer Aided drug design CADD for drug discovery . I enjoy creating innovative tools and methods and am a good team player willing to add value to any research or business . I am a Kaggle Expert in data science competition https : www.kaggle.com tong2016 and have hands on data science experiences in : Machine learning , Deep Learning , Data analysis and Statistics , Database using Pytorch , Tensorflow , Keras , Scikit Learn , Pandas , SQL , Flask Also I have 20 years experience in computational chemistry and bioinformatics : Computational de novo antibody design , Artificial intelligence in drug discovery , computer aided drug design CADD , protein engineering and modeling , next generation sequencing data analysis , metagenomics using MOE , Schrodinger , Rosetta , Amber , Gromacs , SPAdes etc .. Technologies :",
Post Doctoral Researcher Drug Discovery Chemistry . Synthesis of histone methyltransferase inhibitors especially against KMT9 10 and PROTACs as interesting mechanistic tools for cancer therapy in the Jung lab . . Technologies :,molecular glues;developing
"Sr . Director , Oncology Bioinformatics . . Recognized leader in oncology bioinformatics and its application in drug development . Expertise in cancer next generation sequencing NGS , mutation detection and interpretation in cancer patients and their application in translational research .. Technologies :",
"Consultant on science and CFD trading . Assisted in developing a system for weighting vehicles in moving . Developed trading strategies for major indexes and currencies . . If you would like to get in touch , please drop me an e mail at n.damean yahoo.com more than 20 years research and development experience in industry and academics include : micro fluidics , micro droplets , micro and nano technologies and devices , biotechnologies , sensors and actuators , measurement techniques , heat management , automation and control , materials , optics , modelling and simulation , numerical methods , software programming . 10 years teaching experience in engineering mathematics , heat transfer and fluid flow , measurement science , automation and control . PhD Micro Systems , PhD Measurement and Control , MS Mathematics , MS Electrical Eng .. Technologies :",
Associate Principal Scientist . Cell engineering Disease models and Cellular Models for drug screening and Protac validation Toxicological aspects of Cas9 expression : investigation in vitro and in vivo . . . Technologies :,
"Staff Scientist . Senior scientist , independently leading projects within area of expertise , supervising , coordinating , and training junior scientists BS MS PhD . Project lead : structural biology cryoEM of host viral RNA protein complexes involved in translation . Project lead : viral hijacking of host small RNA regulation . Project coordinator : structural biology of PIWI protein complexes . Supervised multiple technicians and postdocs in protein and RNA production , structural methods , and assay development in vitro cell culture . Acquired and analyzed data , generated models , presented at conferences . Established in vitro translation assays for viral reporter genomes using chemiluminescence and fluorescence in 384 well format . Tested effects on translation by small molecules , oligonucleotides , and RNA protein complexes . Established workflow for generation of viral RNA reporter genomes preparation of T7 RNA polymerase , in vitro transcription , purification of RNA genomes , assay development for translation in 384 well format . Used alpha fold to generate models for hypothesis generation . Developed biophysical and functional assays . Synthesized , purified , and evaluated bifunctional compounds targeting RNA in vitro in cell culture . . I use insights from structural and molecular virology to develop tools for RNA therapeutics , with a focus on non coding RNA and translation regulation . I am a passionate , driven , and curious RNA biologist , with solid expertise in integrating structural X ray crystallography and cryoEM and molecular biology with biochemical , biophysical , and cellular methods . I have managed and trained junior scientists in projects ranging from structural biology to cell biology , within academia and for industry collaborations . I have trained and led teams in a defense setting , and have a strong experience in coaching junior team leaders . I am experienced in teaching and curriculum development , and grant writing for research projects and resource allocation .. Technologies : Xray",proteins;structure
"Academy Research Fellow . . During my research career , I have mastered several topics . I have developed efficient stochastic methods for modeling intracellular signaling and single cells , written extensive reviews about postsynaptic signal transduction models for synaptic plasticity as well as astrocyte and astrocyte neuron interaction models , implemented several models to test the reproducibility and comparability of the models , and developed models for neurons , astrocytes , and astrocyte neuron interactions especially related to synaptic plasticity and learning . I also grow oats , barley , and caraway at our family farm in Finland MTY Manninen Minna and Tiina .. Technologies :",
Project Group Leader . . . Technologies : CryoEM,
"Head of Medicinal Chemistry . . Drug discovery chemist , team leader and project leader experienced in : Drug clinical candidate and PET tracer discovery Neuroscience and Oncology therapeutic area People leadership , coaching , mentoring , development Project leadership , matrix leadership , leading cross functional teams Hit lead generation and optimization SBDD and FBDD Synthetic chemistry Parallel medicinal chemistry automation Academic pharma partnerships Due diligences Challenging targets including protein protein interactions , enzymes , proteases , allosteric mechanisms Antibody drug conjugates Artificial Intelligence and Machine Learning applied to drug discovery Working with CRO 's worldwide Intranasal drug delivery research Patent writing . Technologies :",proteins;small molecules;interaction;screening
"Cryo EM Specialist . . Working in the Simone Mattei Team at the Imaging Centre at EMBL Heidelberg as a Cryo EM Specialist providing cutting edge electron microscopy service to users . Previously , I 've worked in the Lab of James Hurley at UC Berkeley , USA , as an EMBO Postdoctoral Fellow using electron microscopy to get a structural and mechanistic understanding of how cells signal nutrient availability . I also implemented new hardware and software solutions that all users in the lab can make the most out of their data . During my scientific education , I 've learned electron microscopy in the Lab of Carsten Sachse at EMBL Heidelberg , Germany , during my PhD thesis and applied it to understand fundamentals of autophagy and to develop new data processing strategies . During my undergraduate studies which involved an 8 month master thesis , I employed NMR spectroscopy , isothermal titration calorimetry and in vitro assays to study aspects of mRNA degradation in the Lab of Remco Sprangers at the Max Planck Institute in T bingen , Germany .. Technologies : CryoEM;ITC;NMR",nucleic acids;structure
"Graduate Research Assistant . . I am a structural biologist interested in investigating the intricate mechanism behind various enzymatic functions using cryo EM . My Ph.D. work is focused on studying the various aspects of replication fidelity of human mitochondrial DNA polymerase gamma . Specifically , I am studying the mechanisms behind 1 proofreading during DNA replication , 2 metal dependent translesion DNA synthesis , 3 long distance lesion recognition ' memory ' , and 4 drug interaction with nucleoside reverse transcriptase inhibitor NRTI . To date , I have one co first author and one co author publications .. Technologies : CryoEM",proteins;interaction;structure
"Bioinformatics Scientist . . I bring a computational focus to the study of complex data generated in systems biology . I am passionate about generating concrete results in cancer biology , immunology , and DNA packaging by developing hands on algorithms that elucidate the structure of the complex networks underlying data . My background combines research in computational systems biology , applied statistics and the mathematics of high dimensional spaces . . Technologies :",
"Scientist . . Dedicated , enthusiastic , and committed scientist . I am a collaborative leader , driving innovation to develop bioanalytical and biophysical concepts . My priority is to work interdisciplinary , concerning a wide range of analytical techniques and the active interaction with outstanding scientists from different scientific areas and countries . I achieved extensive expertise in ; quantitative bioanalytical e.g. HPLC MS , flow cytometry , enzymatic activities , ELISA , immunogenicity , pharmacokinetics PK , and biophysical e.g. ITC , FTIR , and Fluorescence Spectroscopy assays . At BioAgilytix , we want to join our hands and expertise with your organization , to efficiently progress your innovation with the highest quality science .. Technologies : ITC",enzymes;proteins;characterization;interaction
Scientist . . Research scientist at the Swedish Defence Research Agency . Specialized in biochemistry and structural biology . Has been seen doing various flavours of bioinformatics and project management . Technologies :,proteins;structure
Research Fellow part time . Physiological analysis of membrane proteins in Dionaea muscipula . . Technologies :,
"Senior Scientist . DMPK . More than 12 years of academic and industry lab experiences ; Trained and skilled in molecular biology , protein production and purification , glycomodification of protein , drug discovery and rodent work ; 7 years of experience in monoclonal antibody generation from hybridomas , in vitro antibody effector function analyses , luminex and BLI operations , viral transduction and cell line generation ; strong problem solving and data analysis skills ; experienced in equipment operational trainings and presentations .. Technologies : BLI",antibodies;expression;interaction;screening
"Professor . . My research focuses on understanding the formation of functional hierarchically structured materials in order to apply that understanding to make new materials . We use self assembly , driven by interactions between nanoscopic species micelles , nanoparticles , polymers in solution and at interfaces to form materials with organized structures from nm to cm . Understanding interactions between surfaces , nanoparticles and other species is central to our control over structure and thus function . We use time resolved grazing incidence X ray neutron reflectivity , liquid diffraction and small angle scattering to study formation mechanisms final structures . A range of other complementary techniques including TEM , SEM , AFM , NMR , light scattering , surface tension , conductivity , XRD , SESANS , USANS USAXS , gas adsorption are also used to characterise our materials across length scales from tens of ngstroms to microns . At present research areas in the group include self assembly in deep eutectic solvents , the impact of solvent structure on solvation and nanoparticle growth , gels and emulsions prepared using partially oxidised cellulose nanofibrils and their interactions with other biopolymers , novel bio derived surfactants , mesoporous inorganic materials and polymer stabilised lipid nanodiscs for membrane protein supports . Extensive collaborations with other groups in industry and academia apply the novel materials synthesised in our group to applications from delivery of active species , to catalysis and green gels or emulsions .. Technologies : Xray;SLS DLS;NMR",
"Postdoctoral Researcher . Structural Based Drug Design for corona enteroviruses proteases inhibitors and target protein degradation PROTACs . . Experienced Graduate Researcher with a demonstrated history of working in Protein Science . Skilled in X ray crystallography , Biophysics techniques , Structural Biology , Protein Purification , and Protein characterization . Strong research professional with a Doctor of Philosophy Ph.D. focused in Biochemistry , Biophysics , and Molecular Biology .. Technologies : Xray",molecular glues;proteins;developing;characterization;structure
"Assistant Professor . . I work with proteins and their ligands , focused on studying their structural and functional relationship and characterising the atomic details of their interaction . The main tool for this has been NMR spectroscopy ; however , I have also worked with cryoEM , crystallography , protein ligand binding docking computer calculations , molecular modeling and isothermal titration calorimetry . My scientific interest lies within protein science and the discovery of the modus operandi of proteins . My research career has taken me through areas such as cancer and malaria research , RNA biology and studying the side effects from antibiotics . Specialties : Protein science , cancer research , RNA biology , malaria , structural biology , Quartz Crystal Microbalance binding kinetics , ITC , mass spectrometry .. Technologies : ITC;NMR",nucleic acids;proteins;small molecules;interaction;structure
"Director , Bioinformatics Scientific Data Engineering . . Beginning as a molecular biologist at the Salk Institute , most of the last twenty years have been spent working in the pharmaceutical industry providing bioinformatics solutions for biologics drug development , most recently as Associate Director . Whether it was characterizing the soluble proteome at Bayer , or developing new antibody epitope prediction methods at Monogram Biosciences , or building a software development team that created multiple LIMS and cutting edge antibody sequence analysis programs at Xoma , significant impacts have been made at each organization by enhancing capabilities , increasing throughput and creating value . Most recently , work at Xoma was recognized by winning the BioIT World Best Practices Award in 2016 . Authored ten scientific publications , twelve major scientific abstracts and seven patent applications 3 issued . Experience includes hands on research , software and database development , bioinformatics analysis , interdisciplinary teamwork with biologists , business development and legal departments , and management of software development and bioinformatics teams . Strong experience in scientific software development in the areas of genetics , antibody and protein engineering , including next gen sequencing NGS and laboratory information management systems LIMS . Excels at analyzing complex situations and synthesizing new solutions to improve business processes and maximize use of technology . Enjoys the challenge of new scientific problems that allow leadership of a team of creative people to develop innovative solutions that deliver significant impact . Specialties : Python , R , PHP , Perl , HTML , SQL , Django , Jupyter , iPython , PostgreSQL , Oracle , MySQL , database architecture , software design , Accelrys DiscoveryStudio , SAMtools , Knime , MacOS , Linux , Windows , GitHub , protein modeling , antibody structure analysis , NGS , Next gen sequence analysis , Javascript , UI UX , HMMER , CLUSTALW , Biovia ELN . Technologies :",
"Associate Director Medical Affairs . . Associate Director , Medical affairs , solid tumors . Leading Nordic medical affairs team within solid tumors . Working mainly with a TROP2 targeted antibody drug conjugate in development for treatment of a variety of solid tumors .. Technologies :",
"Research Scientist I . . Chemistry Ph.D. with a demonstrated history of working in the chemicals industry . Skilled in protein expression , purification , and structure analysis using solid state NMR , Atomic Force Microscopy AFM , and cryogenic electron microscopy cryo EM . Experienced in elemental analysis using ICP MS and ICP OES .. Technologies : CryoEM;NMR",proteins;expression;structure
Senior Research Fellow . . . Technologies :,
"Scientist . . Highly motivated , productive and extensive experienced scientist with 15 years in cellular and molecular biology especially in two fields , signal transduction and protein modification including ubiquitination . Expertise on multiple levels : molecular biology techniques biochemistry , protein purification and in vitro enzyme assay , in vitro cell based techniques CRISPR Cas9 , signal transduction and light imaging and in vivo utilization of animal models . Demonstrated ability to lead and complete research project in timely manner . Flexible , collaborative , and dedicated team player interested in interdisciplinary approaches and with experience in multidisciplinary collaborations Specialities : Biochemistry , Cell Biology , Molecular Biology , Signal transduction , Genetic , Development Biology , Protein degradation . Technologies :",proteins;characterization
Chief Scientific Officer . . . Technologies :,
"Computational Biologist . . I am seeking new challenges at the interface between computing and biology that combine my interests in microelectronics and data analytics . My prior experience has been in the analysis of complex biological data . This includes microarray expression , genotyping SNP chips , protein expression , and assay qualification . Computational Biology is the field that can synthesize the vast amount of data and identify the patterns . Solving problems in today 's rapidly changing environment takes a team approach . I most recently led a group of computational biologists and an interdisciplinary group to identify biomarkers for oncology therapeutics . Specialties : Bioinformatics , data mining , statistical analysis , microarray analysis , sequence analysis , protein folding , computer programming C , Matlab , Java , and assay development and qualification .. Technologies :",
"Purification Academic . . I am an MSc in chemical engineering from DTU Chemistry with a special interest in computational chemistry and protein chemistry . I am currently working as a scientist at MipSalus ApS in the manufacture of a drug for PKU patients , where my primary focus is on chromatography and the purification of the drug . While studying , my focus was on computational chemistry , where I have participated in multiple research projects on protein stability using MD simulations . At MipSalus , I predominantly work in the laboratory , where I purify the drug . For this , I pack columns , study the affinity of functional groups regarding the drug , and I am in the process of upscaling the chromatography for production . Furthermore , I train new colleagues in chromatography and make protocols for various processes in the production of the drug . For the protocols , I perform literature studies on the theory giving new employees an overview of the processes and why those processes were chosen . On a daily basis , I perform data handling and analyze the results , and thoroughly document the findings . With my background as a computational chemist , I have managed to incorporate my programming skills in the laboratory by programming the pipetting robot to pipette viscous liquids . Words that describe me : independent , initiative , organized , determined , goal oriented , and always in pursuit of new knowledge . I am always looking for new opportunities and to further improve myself as a scientist . It is said about me that I am a good colleague and a fast learner . Special IT tools in which I have gained experience : Gromacs , Amber , Matlab , Python , Linux , Chimera , Pymol , VMD . Some of the essential scientific projects I have participated in while studying have been embossed by computational chemistry in the use of MD simulations , SAXS curve fitting , SAXS guided MD simulations , and enforced rotational MD simulations to examine protein stability , protein composition , and protein conformations . I have developed a manual on how to perform MD simulations and SAXS guided MD simulations using Gromacs for new students at DTU . I am acquainted with machine learning and its tools in Matlab . Keywords : Chromatography Laboratory chemist Computational chemist Protein chemist HPLC Agar plating Bioburden Up scaling Analysis and data handling Documentation Literature studies Programming RLBA Unicorn KTA Matlab Python Gromacs Amber Linux Pymol VMD MD simulations Protein stability Teaching Opentrons Pipetting robot Excel Buffer preparation Protocol SOP writing Manual writing and developing Dialysis Microscopy Resin . Technologies :",
Junior Group Leader . Understanding the molecular mechanism of microbiome driven diseases using Cryo EM . . Technologies : CryoEM,structure
"Bioinformatician . . I aspire to bring together knowledge and technical skills in chemistry , physics , informatics , and biology and apply them to systems which can benefit from an integrative approach . Currently focusing on research in Molecular biology . Exploration oriented , analytical , and thorough . Experienced in system optimization , automation , streamlining , and simplification , and forming models frameworks from first principles . Willing to work both on strategy and planning , or implementation . Passionate about education and personnel training . Extensive experience with protein expression and purification , protein crystallography , cryo EM , bioinformatics , data analysis , and common Molecular biology techniques . Additional direct experience with instrument maintenance and software development geared towards automation and digitization in Life Sciences .. Technologies : Xray;CryoEM",
"Senior laboratory Scientist . I am working as senior laboratory scientist at TATAA biocenter in Gothenburg . I am involved in performing various scientific projects using molecular biology tools : Nucleic acid isolation quality control qPCR performance data analysis NGS Next Generation Sequencing Supporting core facility customers . Welcome to my Profile Driven and energetic individual with a lifelong passion for scientific discovery . Ph.D. degree in molecular and cell biology , with 15 years of work expertise in life science area . Throughout my career , I acquired a diverse scientific expertise making it easy to engage in communication of cutting edge science , or serve as an interface between researchers and the public sector . My colleagues often describe me as social , professional , flexible , problem solving with good planning and organisational abilities , thus contributing to a happy atmosphere in the team Relevant Competences : Molecular biology and bioinformatics tools PCR methods RT PCR , qPCR Nucleic acid analysis , Fluorescence and confocal microscopy Molecular cloning and recombinant protein expression Biological membrane proteins , extracellular localization and function Genetic transformation of micro organisms and higher plants Plant microbe interaction Photosynthetic light reaction in plants and green organisms Abiotic stress in plants mechanisms and adaptations Laboratory Automation : Operation ; Maintenance ; Programming ; Configuration of robotic workstation and liquid handlers epMotion 5070 , Opentrons OT 2 , PIPETMAX Gilson ; Workflow Automation System , from sample preparation to assay setup Skills and expertise : Molecular Biology , Cell Biology and biphysics : PCR methods , performance and data analysis DNA , RNA extraction quantification , quality control Protein purification , quantification fluorescnce and Confocal Microscopy Photosynthesis specific methods : chlorophyll fluorescence , electrochromism , carbon fixation Bioinformatics and genetic engineering : Software applications : SnapGene , BLAST , ClustalW , Primers 3Plus , GenEx Molecular cloning recombinant protein expression Genetic transformation of bacteria , yeast and higher plants Cell culture and in vitro work : In vitro cell culture Microinjection of cRNA into oocytes Immunocytochemistry SDS PAGE Western Blot ELISA , Fragment analyzer Computer Skills : Microsoft Office Suite , Word processing , Data processing and Presentation software Image Processing Illustration and video editing software Knowledge in using languages html , CSS and JavaScript Thank you for visiting my profile and don t to contact me if you have any question Email : azeezbeebo gmail.com Cell phone : 4673 310 28 33 . Technologies :",
"Staff Research Associate 2 . Managed Dr. Andrew Sharabi s laboratory in the Department of Radiation Medicine and Applied Sciences within the Moores Cancer Center of UCSD Health . Investigated HPV oncoproteins using multiple computational biology methods , including sequence homology . Learning both Python and R. Managed laboratory databases of patient samples from multiple clinical trials , including a trial with seven other sister sites . Processed a variety of patient blood and solid tissue samples for these trials . Managed and irradiated multiple tumor types , cell lines , tissues , and materials for clients as manager and sole operator of the Radiation Medicine Shared Resource Facility in the Moores Cancer Center . Assumed management and sole operation in August 2021 . Operated both a Precision X Ray SmART stereotactic X Ray irradiator and a JL Shepherd and Co Cs 137 gamma irradiator . Full time , 40 hours week Promoted in April 2022 to Staff Research Associate 2 . Experienced Staff Research Associate with background in molecular biology . Currently interested in tumor immunology and bioinformatics computational biology . Proven management and supervisor experience across multiple positions . Oracle Financial Cloud , Microsoft Office , FlowJo , Prism , RStudio , Python , and Alphafold enthusiast . Sport climber , boulderer , and a previous climbing competition team coach .. Technologies : Xray",
"Senior Scientist , Computational Medicinal Chemist . . Alisha is an accomplished , self motivated Computational Chemist skilled at leveraging innovative tools such as virtual docking , machine learning , cheminformatics , and method evolution to accelerate the development of drugs that positively impact the lives of patients . She currently serves as a lead Computational Chemist for the Center for the Development of Therapeutics at the Broad Institute of Harvard and MIT , where she is responsible for managing up to three projects simultaneously . Alisha designs and computationally triages compounds using pharmacophore models , predicted ADMET properties , quantum mechanics , molecular dynamics , and QSAR models . She has also gained extensive experience partnering with structural biologists , chemists , protein scientists , and biophysicists , as well as practicing clinicians to advance transformative and challenging projects and achieve meaningful benchmarks . As a recognized expert across multiple computational chemistry platforms Schr dinger , MOE , Forge , Spark , Pipeline Pilot , and OpenEye , Alisha regularly collaborates with external computation groups to discuss , develop , and refine new computational methods . Across her professional and academic tenure , Alisha has been recognized with multiple grants and awards for excellence in research . Her strong work ethic , innovative mindset , and commitment to open collaboration , have also resulted in three first author academic publications .. Technologies :",
"Senior Research Scientist . . I am a research scientist with 14 years of research experience in computational structural biology with strong focus on protein design , docking , molecular simulations , bioinformatics as well as machine learning techniques . I am also well versed in protein biochemistry , highthroughput screening techniques and molecular biology . My technical skills include : Protein design and engineering Rosetta Molecular modeling and simulations Schrodinger , Modeller , Amber , CHARMM , GROMACS , NAMD Template based and template free docking Small molecule library screening and cheminformatics Molecular Biology Cloning , DNA and RNA purification , PCR Protein Engineering Expression Purification Bacterial , AKTA systems High throughput screening techniques Yeast surface display and FACS Biochemical Protein Characterization BLI , HPLC , CD , SAXS Cloning and library construction MiSeq NGS prep and analysis Data science and analytics Python , Shell , Perl , MATLAB , C , Fortran Bioinformatics . Technologies : BLI",proteins;characterization;engineering;interaction
"Bioinformatics Scientist II . My role includes operations and development in the bioinformatics team Bioinformatics Operations Analyzes and refines business and user requirements , and to facilitate bioinformatics systems and software solutions through the entire software development lifecycle . Performs validation studies for bioinformatics software changes and compiles relevant documentations in accordance with Design Control process . Obtains deployment approvals from relevant stakeholders and determines deployment windows with stakeholders . Bioinformatics Development Analyzes requirements and sets up development plan Ensures development meet all product development criteria and quality control measures . Provides development report and technical report for each release Provides development and testing together with documentation to ensure changes meet designed functionalities . . I got my undergraduate degree in Computer Science and my Ph.D. in Molecular Biology . My Ph.D. thesis was focused on the data analysis generated by NGS from Illumina platform . I have a strong background in Illumina sequencing platform , from bench experience working with molecular biology techniques , to a substantial software development and data analysis experience in genomics . Technologies :",
Wissenschaftlicher Mitarbeiter MedWiss . . Chemische Biologie Chemische Synthese von PROTACs f r humane und bakterielle Proteine Synthese zyklischer Peptide und niedermolekularer Wirkstoffe Instrumentelle Analytik GVP und Pharmakovigilanz . Technologies :,molecular glues;developing
"Research Scientist . . I have long standing and comprehensive experience in practical work in laboratories , especially regarding protein engineering , purification and handling . I am specialised in spectroscopy particularly in nuclear magnetic resonance NMR and I am used to work with both bacterial and mammalian cells . During the last few years I have gained a lot of experience regarding the development of descriptive mathematical data models and writing corresponding data analysis programs . On top of that I have been in charge of a multitude of master and bachelor students whose projects I designed and supervised . Furthermore I have experience in teaching and communication of science and scientific concepts to peers and people without scientific background . . Technologies : NMR",proteins;characterization;expression
"Research fellow . I am currently joining the Biomedical Engineering Department in a project called AI Neurology , aiming to develop a deployable software for Stroke . . I am a highly trained mathematician specialising in high performance scientific computing , the human brain network , machine learning and complex systems analysis looking for new challenges and opportunities in developing a new artificial intelligence technology .. Technologies :",
"Vice President , Cancer Immunology Immune Modulation . Drug discovery with the focus on innovative immune modulating concepts for the treatment of human diseases caused by a deregulated immune system , including cancer , chronic inflammation and autoimmune diseases . Approaches include small molecules , biotherapeutics , vaccines and oncolytic viruses . . . Technologies :",antibodies;biologics;small molecules;developing
"Posdoctoral Researcher . Institute of Structural biology BNMRZ Biomolecular NMR spectroscopy . Researcher in Integrative structural biology with a main focus on NMR spectroscopy , but also using X rays , cryo EM and any techniques from biophysics . I am mainly interested in investigating protein conformational changes and protein protein interactions that underline biological functions .. Technologies : Xray;CryoEM;NMR",proteins;interaction;structure
"Principal Scientist . Lead Discovery , Small Molecule Research , Therapeutic Modalities , Roche Pharma Research and Early Development pRED . . Technologies :",small molecules;interaction
"Scientific Investigator Computational Biologist . Member of the Genetic Data Sciences Team since May 2020 . . I am an experienced bioinformatician data scientist who is passionate about delivering high quality data and informative analyses to colleagues . I love the challenge of using using complex algorithms to infer exciting insights and then to be able to shrink warp the results into easily understandable reports and pictures . I have been fortunate to work in some great institutes and with some great groups . This has varied from large software projects like Ensembl , to more intimate projects , working one on one with scientists and biologists . Both ends of the spectrum have their own challenges but this is what makes things interesting Either working one to one and many to many , still means that you must strive to make your work comprehensible to whatever audience . I 'm driven to make data analysis as clear and concise to biologists and scientists without a technical background . Equally providing technical advice to colleagues with a similar technical backgrounds to mine should also be clear and concise . While working in large institutes is great , working in great institutes is also bad because of silo mentalities . So one of my common memes in my various work places has been to get colleagues with different , but complementary skills , to talk to each other Coffee meet ups , short spot light presentations of a potted history of a person 's career and interests have been some of the tricks that I 've tried . Specialties : Computational genomics , Next Generation Sequence analysis , exome analysis , comparative genomics , DNA sequence analysis , Personalized cancer medicine , automated clinical document generation , data integration , data interpretation . Programming languages : Perl , R programming language , Bioconductor , Python . High performance compute clusters , computational pipeline development , Docker , algorithm integration , ad hoc bioinformatic solutions , algorithm development , database implementations , DAS , website design and implementation .. Technologies :",
Machine Learning Scientist . . . Technologies :,
"Sr . Postdoc . Engineered developed a genetically encoded nanoantibody derived nanoparticle probes containing targeting module functional module . This probe can target proteins , DNA , or RNA in vivo and be used on fluorescence microscopy and electron microscopy , also potentially on Cryo EMT , MRI , X ray . This probe has multiple advantages over nanogold particle probes that are frequently used in EM imaging field . R D experiences in the establishment of a company IconOVir Contribute to design and establishing oncolytic adenovirus libraries and screen for synthetic adenoviruses that can specifically kill P53 or RB negative cancer cells , or specifically target cancer sites in multiple cancel animal models , et al . The work in the period resulted in one co inventor patent and two first author papers in preparation . . Hi everyone , Thanks for viewing my profile . Here are my summarised skills . Let me know if you are interested and I would be to very happy to share with you a few interesting stories . A strong background in synthetic biology , biomedical engineering viruses , cells , DNA , and proteins , biochemistry , cell biology , virology , and fluorescence microscopy . Get a challenging structure based nanoantibody VHH , or single chain antibody scFv engineering project to work . Expertise with molecular cloning techniques enzyme digestion ligation , Gibson assembly , In fusion cloning , Gateway cloning , Slic cloning , Golden Gate cloning , QuickChange site directed mutagenesis . Familiar with protein purification from E.coli and mammalian cells . Expertise in the protein charaterization native gel , SDS PAGE , and western blot . Expert with statistic data analysis ex : Prism and presentation power point . Excellent oral and written communication skills in english , multiple experiences of presentation in international conferences . An innovator with track record in molecular design of biologics , of creative and proactive approach to problem solving , and strong analytical skills . Strong track record of paper publications 6 first author papers and one invention patent . Love synthetic biology and biological engineering . A team worker that enjoys communicating with people and eagers to learn new techniques . R D experience in the early lab investigation stage of gene therapy company Iconovir oncolytic adenovirus engineering , library establishment , and mid high throughput cell level screening . Experienced in CRISPR , TALEN , PiggyBac gene editing . Familiar with lentivirus , retrovirus , adenovirus , AAV production . Skilled in studying protein protein interaction yeast two hybrid , epitope tagging co IP , endogenous protein co IP and protein DNA interactions CHIP , CHIP seq , EMSA . Experiences in Next generation sequencing NGS RNA seq , CHIP seq .. Technologies : Xray",antibodies;biologics;carriers;characterization
"Senior Scientist . . Keltic Pharma Therapeutics is a spin out company based on the work of Professor Andrew Tobin , Andrew Jamieson , and Graeme Milligan . Located in the new Advanced Research Centre at the University of Glasgow , commercially headed by Dr Elaine Sullivan CEO , we are aiming to find the next generation lead anti malarial therapeutic . . By trade , I m a research scientist with sixteen years of academic and industrial experience . After post doc ing in both the US and UK , in 2017 I transitioned into industry where my focus has been in the drug discovery sector . . Previous placements include : the University of Aberdeen , Glasgow , and California , San Diego ; GlaxoSmithKline , BASF , Novabiotics , Commercial Microbiology , Scottish Water Solutions Bardon Aggregate , and the Medical Research Council Technology . I have contributed to 17 papers , published in journals including Nature , Communications Biology , FASEB and Molecular Pharmacology . . Areas of scientific expertise : . GPCRs , molecular pharmacology , biased signalling , BRET receptor characterisation assays , residence time and kinetic assessments ; small molecule and fragment screening from small scale target characterisation to HTS ; general assay development ; correcting failing and problematic assays ; enzyme and kinase assay development ; primary human and immortalised cell culture ; development and screening of assays using primary cells . . Technologies :",small molecules;interaction;screening
Senior scientist at Cryo EM Knowledge Hub . . . Technologies : CryoEM,
"Senior Formulation Scientist . Formulation development for pDNA drug candidates against virus infections and cancer . . 10 years of industrial experience in formulation development , method development and stability assessment General knowledge of biologic drug development and CMC process from discovery to IND submission Familiarity with USP , PhE and regulatory requirements for biologics Experience in writing Module 3 IND submission documentation Ability to lead , coach , develop and manage a team of scientists and technicians Experience in managing external collaborations with CRO CMO Innovative , with a passion for driving scientific excellence and a continuous improvement mind set Thorough knowledge of physico chemical properties of proteins and peptides including antibodies , which plays a critical role in formulation development and stability assessment 12 years academic experience in investigation of protein structure , stability , thermodynamics and intermolecular interactions Deep understanding of characterization methods for macromolecules and their applicability for stability investigation Technical know how of operation principles and capabilities of biophysical and analytical equipment Track record of scientific publications in peer reviewed journals . Technologies :",antibodies;biologics;formulation;quality;stability
"Research Scientist . Specialized assay scientist in high through put screening team . Activity and Chemico physical stability testing . Development of custom substrates for highly specific performance screening . Data Science Python . . Assay scientist with key compentency in developing small scale model assays used for both high throughput and manual screening . Primarliy within protein and enzyme applications . Key personal qualities include curious , analytical pragmatic , structured and result oriented . Professionally trained and experienced in organic chemistry MSc and biophysics PhD .. Technologies :",enzymes;proteins;screening;stability
"Director , UCL Advanced Research Computing Centre . I am Director of the Advanced Research Computing Centre at University College London . UCL ARC has a hybrid mission : to provide the computing , data , software and networking infrastructure and skills that empower computational science and digital scholarship across the university and its partners , and to deliver world leading research in digital research infrastructures and their application . . I am Director of the Centre for Advanced Research Computing at University College London . UCL ARC has a hybrid mission : to provide the computing , data , software and networking infrastructure and skills that empower computational science and digital scholarship across the university and its partners , and to deliver world leading research in digital research infrastructures and their application .. Technologies :",
"Associate Director , Principal Scientist Project Team Leader . Department of Drug Discovery Oncology Biology . Experienced and accomplished project team leader and research scientist in oncology drug discovery in the pharmaceutical biotech industry , with a solid track record of successfully translating small molecules from discovery into clinical development : . Project team leader with demonstrated ability to effectively lead and manage multi disciplinary research teams composed of PhD level scientists with various expertise on medicinal chemistry , structure based drug discovery , HTS screening , biochemical and cell based assay development , formulation , pharmacology , DMPK , toxicology , and translational medicine . Strong social and leadership skills , supervising others efficiently by providing value added feedback coaching , guidance , objective setting , and performance management to team members . Research scientist with in depth understanding of cancer biology , intracellular signaling and gene regulation pathways and with thorough know how in biochemistry , molecular cellular biology , and biomarker discovery validation to support innovative drug discovery and translational research of small molecules . Intellectually flexible with a diverse expertise working on kinase , kinesin and protein protein interaction inhibitors , as well as epigenetic regulators ; can quickly assimilate new subjects and techniques , identify key concepts , and solve problems creatively . Proven ability to successfully establish and coordinate international collaborations with various internal groups , and with external partners such as academic institutions and industries in US , EU , Japan and China . Hands on experience in filing Investigator Brochures , clinical protocols , and IND IMPD regulatory documentations , to support US FDA and EU EMEA approval for first in man clinical studies . Accomplished writer , editor , and public speaker , with a strong record of scientific achievements . Able to present complex material in a clear , concise , and persuasive manner . . Technologies :",proteins;small molecules;interaction;screening
Senior Director of Software and Computational Biology . . Quantapore is hiring .... Technologies :,
"Bioinformatics Scientist 2 . . Senior computational biologist and mathematician with a broad range of experience in high throughput , multi omics , high dimensional data analysis and mathematical modeling . My work is guided by questions on tumor oncogenesis and evolution , as well as host immune responses to viral infection . I am skilled in the analysis and interpretation of scRNA seq RNA seq WES WGS , with 3 years of supervisory experience and project management .. Technologies :",
"Associate Professor : Biomedical Engineering , Bioinformatics , Microbiology , NEIDL . We are an interdisciplinary lab at the interface of genomics , molecular biology , computational biology , electrical engineering , and technology development . We develop computational and high throughput experimental methods to study the systems biology of microbial organisms and translate the resulting knowledge into biomedical applications including biosensors and wearables . . Professor , scientist , engineer , and manager with 20 years experience working in both biotech and academia . Skilled in Computer Science , Bioinformatics , Genomics , Life Sciences , Molecular Biology , and Electrical and Biomedical Engineering .. Technologies :",
"Senior Scientist , Bioinformatician . . Established and highly motivated bioinformatics scientist with expertise in scientific programming , data analysis , protein engineering and structural bioinformatics ; harbors a strong passion for innovative research and creative problem solving . Computational Methods Software Engineering High throughput Data Analysis LIMS Platform Development Library Design Sequence targeted Drug Design Protein Engineering Structural Analysis and Modeling Sequence activity Analysis Multi disciplinary Teams Project Guidance and Management Specialities : PERL , C , SQL , data analysis pipelines . Technologies :",
Scientific Technical Leader I . . I am interested in exploring new ways of adapting technology and business to the field of healthcare . ps . I do n't work in Software Engineering or Testing and request not to be approached for such roles .. Technologies :,
"Assistant Professor . . My lab studies the misfolded proteins and self propagating protein seeds of neurodegenerative diseases including Alzheimer s , chronic traumatic encephalopathy , and prion diseases . We use ultrasensitive diagnostic assays , cryo electron microscopy , cellular and animal models to understand the structural underpinnings and biological mechanisms that contribute to the formation and accumulation of neurodegenerative disease associated protein seeds .. Technologies : CryoEM",idps;structure
"Senior Scientist . Senior research scientist within Global Biotherapeutic Technologies GBT department of Pfizer . Project work involves antibody generation , engineering and characterisation . . Specialties : Molecular Biology . Protein display and library technologies . Antibody engineering . Mammalian cell culture . Tissue sample manipulation vaccine production . In vitro and biosensor based assay development . Data analysis and interpretation . Report and manuscript preparation . Technologies : SPR",antibodies;characterization;engineering
"Head of Electron Microscopy AFMB Marseille . . Specialties : Protein DNA X ray crystallography , Cryo electron microscopy , Structural and Molecular Biology . Technologies : Xray;CryoEM",nucleic acids;proteins;structure
"Senior Scientist . Novel HSP90 inhibitor development for human prostate bladder cancer Work focused on the overexpression of Heat Shock 90 Protein Hsp90 in prostate bladder cancers and the development of novel Hsp90 inhibitors as chemo drug for cancer treatments Hsp90 recombinant protein purification using HPLC and FPLC Study the specific binding of the drugs to different isoforms of Hsp90 using FL spectrophotometry Perform cell based luciferase refolding assay , and determine the IC50 number of the Hsp90 inhibitors Immuno histochemical evaluation the anti proliferative and cytotoxic effects of Hsp90 inhibitors Quantify protein expression using Western blots UV Fluorescent probes Protein extraction and DNA isolation from drug treated cancer cells Tumor M2 PK : A Novel Urine Marker of Bladder Cancer Design and develop 96 well plate assay to investigate urine glucose values in diabetes patients Assess bladder cancer cell proliferation under differential glucose levels by hexosaminidase assay Perform Western blot and Blue native analysis for protein expression of PKM2 in cancer cells Study PKM2 dimer tetramer conversion and inhibition by Shikonin an anti cancer herb Develop , optimize and standardize ELISA to analyze PKM2 values in human urine sample of bladder cancer patients Techniques : Proteins purification by AKTA Xpress purification system GE Healthcare ; Intrinsic fluorescence measurements by a SprectraMax M5 Spectrophotometer ; Spectroscopic analysis of proteins and DNA using the CD , Nano Drop and BioTek Synergy HT systems ; Automated capillary electrophoresis and western blotting using Invitrogen E Base and iBlot ; Near Infrared Fluorescence western blot analysis using LiCor Odyssey system , Imaging and analysis of gels and westerns using the UVP Chemi Doc It Imager . PhD in Biophysical Chemistry area with over 13 years working experience Wide knowledge on protein related research , especially in purification , quantification and characterization Hands on experiences on a variety of analytical methods such as specific binding assays , Electrophoresis Western Blot , and ELISAs Expert on characterization of drug stability and in vitro drug activity test Excellent experiences on bioanalytical assay development , quantitative qualitative analysis of pharmaceutical products and biological samples Cell Culture , Protein extraction and RNA isolation , Plasmid Purification PCR and RT PCR , Transfections and infections on multiple cancer cells lines With expertise in HPLC , LC MS , FPLC , FTIR , FL , DLS , CD , UV Vis , DSC , TLC , and Cryo EM Execute multiple simultaneous projects that require creating study protocols , experimental design , updating SOPs , and planning timelines . Trains , coaches or mentors students in laboratory techniques and research projects . Extensive computer skills in data analysis and management Great ability to function well within multidisciplinary teams . Technologies : CryoEM;SLS DLS;DSC",biologics;small molecules;characterization;interaction
"Scientist II . Method development , method validation , and sample analysis under GLP conditions for anti drug antibody assays , pharmacokinetics assays , and neutralizing antibody assays , serving clients in the pharmaceutical biotech industry . . PhD graduate from Rutgers University whose thesis project dealt with HIV 1 latency , where our lab worked to deduce the different molecular pathways involved in forming and maintaining the latent state , with the goal of searching for small molecule drugs that can reverse it . Currently a Scientist II at a contract research organization , where we serve the pharma biotech industry to analyze samples clinical and pre clinical to support their products ; much of our work deals with biologics . I 've worked to develop and validate methods under GLP conditions and used them to analyze samples . Technical Skills : Mammalian tissue culture , PBMC purification , lentiviral vector construction and production , PCR , qPCR , DNA RNA extraction and purification , transformation , transfection , luciferase based cell assays , plasmid preparation , ELISA , MSD , Watson LIMS . Technologies :",antibodies;biologics;quality
"Scientific Review Officer . . I am a scientist , team leader , project manager and liaison with over 31 years of experience in the biomedical field . My credentials include a consistent track record in biomedical research planning and development of collaborative strategies , publication in top gear journals Science , Nature , PNAS , strong communication skills , and excellence in human relations , staff recruitment and retention . As liaison , I designed and implemented strategies where academic and corporate biomedical resources were effectively merged to ensure a successful and timely completion of collaborative projects . My research endeavors have taken me through multiple fields , from cancer biology to neuroscience neurodegenerative diseases , immunology immune synapse , inflammasome , virology HIV , Flock House Virus and cell biology integrins , GAP junctions , cadherins , catenins , Golgi apparatus and organelle behavior during mitosis , providing me with an excellent , broad view of biomedical research . The common thread between these different fields has always been structural and morphological work , using mid to high resolution imaging techniques light , electron and cryo , with emphasis on approaches to correlated light and EM cryo EM , along with molecular probes development , assessment and implementation to undercover novel mechanisms of action for key proteins and cellular elements . Of particular significance have been the seventeen years spent working at the National Center for Microscopy and Imaging Research UCSD , in close interaction with R.Y Tsien Nobel Prize for Chemistry , 2008 and his group . I m currently employed at Scintillon in San Diego where I continue to tackle projects in need for correlative light and electron microscopy , with particular emphasis on cryo electron microscopy and cryo electron tomography .. Technologies : CryoEM",proteins;structure
"Development Regulatory Bioanalysis Research Scientist . Development validation of small large molecules peptides , free total proteins bio analytical methods by LC MS MS PK , ADA biomarkers . Preclinical and Clinical samples analysis by LC MS MS methods GLP environment . . Skillsand experience : MS MS HPLC , UPLC 2DLC quantitative analysis for small large molecules peptides proteins Development validation of LC MS MS methods GLP environment Development validation of hybrid LBA MS assays by Immuno Capture : free total antibody PK , targets biomarkers and Anti Drug Antibodies ADA measurement Scientific presentations Fr Eng Drawing : Adobe illustrator , Sketchup Bioanalysis of preclinical Clinical samples Identification by GC MS In Process Control Quality Control analysis . Technologies :",peptides;small molecules
"Data Analytics Programme Manager . Manage R D cross functional projects in pet healthcare Provide technical leadership on experimental and RWE data analysis Statistics , IT Manage stakeholders across the different divisions Comms , Legal , R D . I am a data scientist working on the development and application of statistical and machine learning algorithms to gain insights from complex multidimensional data , with a particular focus on bioinformatics , healthcare data , and petcare data . I have a background in Computer Science B.Sc . and M.Sc . , applied Mathematics and Statistics Ph.D. , and computational biology bioinformatics . I have been working in collaborative teams composed of data scientists , machine learning researchers , engineers , physicists , biologists , mathematicians , and computer scientists to solve a variety of computational and statistical problems . I developed new computational methodologies and tools to investigate biological systems by analyzing a variety of data including expression data , networks , karyotypes , epidemiological data , healthcare data , and anatomical features . I have an extensive experience in programming , designing complex statistical pipelines , producing informative graphical visualizations , and building interactive interfaces to explore data .. Technologies :",
"Postdoctoral Research Associate . I am a postdoctoral research associate in the group of Dr Rivka Isaacson , based in the Department of Chemistry at King 's College London . My BBSRC funded project is being conducted in collaboration with Dr Amy Camp of Mount Holyoke , USA and Dr Marta Carroni at SciLifeLab , Sweden . Together we 're aiming to characterize novel proteins involved in the sporulation process of Bacillus subtilis . . I m a protein biochemist undertaking a postdoctoral research position based within the Department of Chemistry at King s College London . I have a PhD from the University of Liverpool where I used a variety of biophysical techniques , primarily NMR and TEM , to study alpha synuclein , a protein which plays a key role in Parkinson s disease . This has left me with a love of proteins and the suite of biophysical techniques used to study them , especially in the context of neurodegeneration . More generally , I am fascinated by the biochemical and biophysical underpinnings of disease . As part of my postdoctoral work I am now trying to harness these same biophysical techniques , whilst also developing new skills in cryo EM , to probe the 3D structure of several proteins involved in the process of spore formation in Bacillus subtilis . Over my scientific career thus far I have handled various types of proteins considered particularly challenging , including intrinsically disordered proteins IDPs , membrane proteins , and redox sensitive proteins . I thus have an awareness of some of the more unique aspects of their handling preparation e.g. ultracentrifugation , detergents , transient stable transfections , necessity of reducing agents etc . My key skills include : Recombinant protein expression E.coli , HEK 293 Protein purification Protein NMR 1Ds , HSQCs , WaterLOGSYs , NOESYs , COSYs , TOCSYs Transmission Electron Microscopy TEM Protein crystallography Circular dichroism Fluorescence assays e.g. thioflavin T Cell culture Western blotting Liquid scintillation counting In summary , I love proteins and enjoy working in convivial , multi disciplinary environments to understand them in greater detail .. Technologies : Xray;CryoEM;AUC;CD;NMR",idps;proteins;characterization;structure
Bioinformatics and Data Scientist . . Computational Biologist and Bioinformatician interested in tackling open questions at the frontier of cancer genomics and immunogenomics . See my google scholar page https : scholar.google.com citations user AAyVb8AAAAJ hl en oi ao for my list of peer reviewed publications .. Technologies :,
"Senior Director of Bioinformatics . . I am a bioinformatician and computational biologist with extensive experience working on type 2 diabetes mellitus , oncology , and multiple sclerosis . I graduated with my Ph.D. in Biomedical Engineering from Boston University in 2010 from the Computational Genomics Laboratory and worked in early and translational Oncology Research at the Novartis Institutes for Biomedical Research in Cambridge , MA , USA until March of 2015 . From March of 2015 until June of 2021 , I was employed at Verily formerly Google x Life Sciences . My responsibilities ran the gamut , but I was most recently the Technical Lead for Computational Biology in Verily formerly Google x Life Sciences , where I split my time between leading research and development of machine learning methods for life science data , writing and vetting analytics plans for various ongoing scientific studies , and together with the people manager of computational biology making sure team members are set up to succeed have positive impact . I was also the Scientific Lead on various internal studies within Verily looking to generate evidence and test specific hypotheses on cardiometabolic diseases such as type 2 diabetes mellitus using clinical and molecular data collected as part of Project Baseline . I 'm currently employed at PrognomiQ as the Director of Bioinformatics , where we are looking to deploy state of the art , high throughput and reproducible multi omics towards early detection and treatment of complex diseases . I enjoy strategizing and setting direction , but also getting my hands dirty writing and reviewing code , doing statistical analyses , generating and communicating reports , and mentoring growing junior colleagues . It 's been fun .. Technologies :",
Wissenschaftlicher Mitarbeiter . . Cancer Selectivity Nanobodies PROTACs Exploring nano biotechnologies to gain cancer selective constructs . Technologies :,molecular glues;antibodies;developing
"Associate Director . . Energetic and motivated computational chemist with extensive expertise in development and implementation of algorithms and tools for protein modeling and computer aided drug design . Experience of working with multi disciplinary teams including organic medicinal chemists , crystallographers , biologists and pharmacologists . Specialties : molecular modeling , protein engineering , development of biomolecular force fields , virtual ligand screening , docking , crystal structure prediction of complex organic compounds . Technologies :",
"Process Development Scientist II . . Experienced Protein Biochemist with 12 years of experience in protein structure function studies and characterization of challenging proteins . Established track record in molecular biology , cloning , protein purification , biophysical and functional characterization DLS , SPR , Spectroscopy , native MS , Western Blot , CD , structural characterization bioinformatics , X ray crystallography and cryo EM and Enzymology enzyme activity assay development . Experienced in working with soluble , membrane and membrane interacting proteins . Proven leadership qualities with experience in leading collaborative efforts , providing mentorship and training to students . Excellent communication skills .. Technologies : Xray;CryoEM;SLS DLS;SPR",enzymes;membrane proteins;proteins;characterization;interaction;structure
"Postdoctoral fellow , group of P.Schultz , Department of Integrated Structural Biology . Structural studies of large molecular complexes involved in transcription initiation and repair by cryo EM microscopy . . . Technologies : CryoEM",peptides;proteins;structure
"Principal Scientist . . RNA Structural Biology ; RNA Biochemistry , RNA Biology , and RNA protein Complex ; RNA targeted small molecule drug discovery ; Structure and Function of Telomeres and Telomerase ; In cell NMR and protein biophysics under physiologically relevant conditions . Specialties : Structural Biology , NMR , cryo EM , Computational Modeling Publications H index 16 ; citations 1800 are available on Google Scholar : https : scholar.google.com citations user eK iKd4AAAAJ hl en . Technologies : CryoEM;NMR",nucleic acids;proteins;interaction;structure
"Senior Director , Head of Bioinformatics . Developing and deploying existing and new analyses and pipelines to engineer B cells using CRISPR for therapeutic use . . Currently working in a startup developing therapeutics based on B cell engineering . Engineered B cells can secrete proteins vital for addressing medical needs . Previously worked in a startup on developing new oncology drugs taking advantage of synthetic lethality , developing new analyses for genome wide CRISPR screens and mining publicly available cancer data . Worked on featured snippets , a part of Google 's search group . This is the box you see at the top when you type in a query like why is the sky blue . Most of this work is in C and Python . Principal developer of the open source software MolBioLib on SourceForge , that is a C 11 framework for rapid development of tools , particularly those related to bioinformatics . It has been used in 11 published papers , with several more papers pending . It was also used as the primary framework at Seres Therapeutics for their primary analysis pipeline . Experienced in microarray , Sanger , and next generation DNA RNA sequencing algorithm development , annotation , and amalgamation and analysis of multiple data sources including immunodeficiency causing variants , RNA Seq , RIP Seq , ChIP Seq , cDNA , chromosomal conformation , and bacterial 16S region . Experienced in large scale production software development , massively parallel systems , efficient methods of solving nonlinear time dependent PDEs , and nonlinear dynamical systems chaos theory . Specialties : C , algorithms , natural language processing , bioinformatics , microbiome , numerical analysis , finite element methods . Technologies :",
"Bioinformatics Specialist . 1 . Inventing new methodology for aligning cryo electron tomographic tilt series . 2 . Developing AreTomo , a multi threaded and multi GPU Linux application that fully automates the entire process from CTF correction , to tomographic tilt series alignment and reconstruction of 3D volumes . 3 . Developed MotionCor2 , a multi threaded and multi GPU Linux application that corrects electron beam induced sample motion . 13 licences have been issued to industrial users in 2018 including Pfizer and Amgen . 4 . Developed distributed multi GPU linux application for high thoughput electron tomographic reconstruction 5 . Developed a robust and efficient predicative data collection scheme for the acquisition of electron tomographic tilt series and implemented into UcsfTomo , a highly acclaimed windows application that enables full automation of tomographic data collection without human intervention . 6 . Routinely providing consultation to scholars not only at UCSF but also worldwide . . As an enthusiastic scientist and software developer , I endeavor to solve challenging data collection and image processing problems in cryo electron tomography cryoET and cryo electron microscopy cryoEM . My interest covers inventing new methodology , developing parallel algorithms , and implementing multi threaded and mult GPU CUDA applications . As the author of UCSFTomo and MotionCor2 , two highly acclaimed applications routinely used in cryoET and cryoEM , I am very proud of my work that helps so many people in cryoET and cryoEM communities . . Technologies : CryoEM",
"Research Tech III . Research and Development in collaboration with postdocs and graduate students Understand mechanisms of ebola glycoproteins , coronavirus spike glycoproteins and nucleocapsids by structural and functional studies under BSL2 conditions Perform the entire cycle of molecular cloning including primer design , PCR , plasmid preps and sequence verification for cloning viral structural proteins into different vector backbones . Study key residues in viral glycoproteins for neutralizing activity by mechanisms such as site directed mutagenesis . Express Ebola viral glycoproteins , coronavirus nucleocapsid proteins and antibodies from different expression systems including bacteria , insect and mammalian systems . Purify proteins using AKTA FPLC systems that employ affinity columns such as streptactin and proteinA , ion exchange columns such as monoQ and size exclusion Superose columns for applications such as cryoEM imaging and X ray crystallography . Make protein antibody and protein RNA complexes and isolate different oligomeric protein states using size exclusion chromatography Prepare , screen and optimize negative stain grids of protein complexes in a Titan Halo side entry electron microscope Freeze samples on grids under cryo conditions using the Vitrobot Setup data collection on Titan Halo using serialEM and EPU Process micrographs obtained from electron microscope to obtain 3D electron density maps Characterize binding activity of antibodies by ELISA and cell surface staining Determine IC50 of neutralizing antibodies by performing a pseudovirus neutralization assay . I am currently working as a Research Technician in Erica Ollmann Saphire lab at La Jolla Institute for Immunology LJI . My expertise lies in the field of molecular cloning and protein sciences . I have also gathered 2 yrs experience in the field of structural biology , mainly cryo EM and the use of electron microscopes . Prior to LJI , I was a research associate at Active Motif where I learnt to express , purify and validate antibodies for the commercial pipeline . I have 2 years hands on research experience in a molecular biology lab at UCR where I earned my masters degree with a thesis and 3 months of internship experience from Teco Diagnostics . I have an undergraduate degree in Electronics Engineering and 5 years work experience in software industry . My skill sets include : ELECTRON MICROSCOPY SKILLS Use , handle , transfer and store grids for negative stain and cryo . Make and optimize grid preparation for negative stain , screen grids and setup data collection in a Titan Halo side entry electron microscope CryoEM sample prep Clip grids for cryoTEM Process negative stain and cryo datasets to obtain low and high resolution electron density maps LABORATORY SKILLS Nucleic acid Molecular Cloning both restriction enzyme dependent and seamless Gibson cloning : Competent in the complete cloning cycle including techniques like primer design , PCR , DNA extraction , agarose gel electrophoresis and DNA sequence analysis Site directed mutagenesis Experience working with BioXp 3200 automated DNA fragments synthesis platform for synthesis of gene blocks RNA isolation by invitro transcription Protein Recombinant protein expression and purification from E. coli metal affinity based column chromatography , mammalian 293 T and CHO cells and insect systems Schneider S2 cells AKTA FPLC systems Use , maintain and troubleshoot Antibody digestion from IgG to Fabs for structural studies Centrifugal filters Amicon , vivaspin and zeba Pseudovirus neutralization assays Octet BLI SDS page gels , western blots , dot blots , immunoprecipitation FRET assays , MTS assays , ELISA , Luminex based assays SOFTWARE SKILLS Bioinformatics : BLAST , Chimera Software tools for cryoEM data analysis CISTEM , cryosparc Imaging : ImageJ , Imagelab Snapgene viewer , Chromas , VectorNTI , CLC Sequence Viewer , GraphPad Prism Filemaker database , LIMS Thermoscientific Cellnsight CX 5 SQL , python basic programming , bash scripting MS office : Word , Excel , Powerpoint . Technologies : Xray;CryoEM;BLI;FRET",proteins;characterization;structure
"Principal Bioinformatics Workflow Developer . making analysis pipelines run harder , better , faster , stronger . I shout at genomes for money . Technologies :",
"Research Fellow . Using deep learning models to assist , simplify and streamline cryo electron microscopy data acquisition cryoRL and data processing MicAssess Leading the development of an easy to use and customizable web application for cryo EM data processing cryoHub Interested in developing 3D reconstruction algorithms in cryo EM . Using deep learning models to assist , simplify and streamline cryo electron microscopy data acquisition cryoRL and data processing MicAssess Leading the development of an easy to use and customizable web application for cryo EM data processing cryoHub Interested in developing 3D reconstruction algorithms for single particle cryo EM . Technologies : CryoEM",
"Scientist Structural Biologist . . I 'm a structural biologist for Loxo Oncology in Boulder , Colorado , interested in using X ray crystallography and cryo electron microscopy in combination with biochemical assays to probe the structure and function of medically relevant proteins .. Technologies : Xray;CryoEM",proteins;structure
Deputy Head of Computing . . . Technologies :,
"Senior Director , QSP . . I am a computational biologist with several years of experience in bioinformatics , computational structural and systems biology , and mathematical modelling . With my mathematical and bioinformatics background , I did my PhD at Cambridge University , where I investigated and made an evolutionary analysis of the local structural environment of amino acids , developed a method CRESCENDO to predict the functional sites of protein families and applied it in sequence structure homology recognition and protein protein docking . After my PhD , I worked at MRC NIMR , London , to carry out my postdoctoral research on de novo protein structure prediction , refinement and ranking of the predicted protein models based on the functional site potential . Following MRC NIMR , I worked at EMBL EBI , as a Project Leader for BioModels , a repository of mathematical models of biological biomedical systems . Currently , I am working at Certara as a Principal Scientist Quantitative Systems Pharmacology . . Technologies :",
"Postdoctoral Researcher . My current research is focused on functional and structural characterization of ribosomal complexes in mammals in healthy and cancer cells using mainly in vitro protein translation assays , fluorescence , microfludics and cryo electron microscopy . . Multidisciplinary Scientist with 9 year international experience in structural biology and biochemistry . My research interests were always focused on structure function relationship of macromolecules implicated in diseases malaria , colorectal cancer , heamatologic diseases . PhD in Structural Biology EU funded FP7 Marie Curie research network focused on pre clinical drug development for infectious diseases and MSc in Biophysics . Research areas : protein nucleic acids interactions , drug discovery , structural biology , colorectal cancer , parasitology Full professional competence in English , French and Polish .. Technologies : CryoEM",proteins;structure
"Director Computer Science , SRI . Computer science innovation and research for long term positive impact . A list of scientific publications : http : scholar.google.com citations hl en user VMn7Ss0AAAAJ . Leading long term high impact research and development . Specialties : Information security , formal methods , computational biology , nanoelectronics Government research , value creation , management of innovation . Technologies :",
Senior Scientist . . I am a Scientist with demonstrated work capacity in both translational and fundamental research . Energetic research professional with a Ph.D. degree in Biomedical Sciences and skills in Functional Genomics and Proteomics Research . Competent in applying Computational and Bioinformatics tools .. Technologies :,
"Microbiologist . . As a biotechnologist microbiologist I worked for several years in university research laboratories . However , I have also spent research work at research centers and public environmental protection agencies . Many years of extensive experience in development and validation of molecular biological assays , fascination with research , scientific analysis of experiments , performance of biochemical working methods , questions in biochemistry and molecular microbiology complete my professional domain . I have also experience with biophysical characterization of the nucleic acid binding and unwinding activity of protein , with analysis of their role within eukaryotic and prokaryotic genome . Currently I deal with molecular diagnostics in the medical field , with particular attention to COVID19 challenges .. Technologies :",nucleic acids;proteins;interaction
"Associate Director , Bioinformatics and Data Science . . . Technologies :",
"Vice President . This area is fully embedded in early drug development turning scientific ideas into great drug discovery programmes to benefit the patients . We work across all NN indications and with multiple drug modalities . The area consists of six individual department representing centre of excellence capabilities within assay , analysis characterization . The Structure Interactions department uses a wide range of cutting edge SPR , ITC , X ray and cryo EM technology platforms to characterize the structure and binding properties of peptide and protein ligands The Screening Bioassay Technology department develops high throughput cellular and immunochemical assays to ensure high throughput screening of drug candidates by using various read out and advanced technical solutions . The team also provides insights spanning immunogenicity risk , cellular binding and uptake mechanism , absorption predictions by using advanced in vitro models . The Research Bioanalysis department quantifies biomarkers and peptide protein analogues from in vivo studies using automated immunoassays to aid firm PK PD understanding . The Discovery ADME department uses advanced LC MS platforms for bioanalysis and metabolism studies of plasma samples . The MS Characterization department uses state of the art LC MS platforms for the physicochemical characterization of new drug candidates including chemical stability , and impurity formation . The Analysis Separation department develops analytical separation and chromatographic analysis methods for drug candidate formulations and in process analysis . . I am heading Assay , Analysis and Characterization , an area in Research Early Development in NN . This area is fully embedded in early drug development turning scientific ideas into great drug discovery programmes to benefit the patients . We work across all NN indications and with multiple drug modalities . The area consists of six individual department 90 FTEs representing centre of excellence capabilities within assay , analysis characterization .. Technologies : Xray;CryoEM;ITC;SPR",peptides;proteins;small molecules;characterization;interaction;screening;structure
"Senior Scientist . BIOLOGICAL DIVERSITY BY DESIGN Seres Therapeutics has built a proprietary discovery and design platform that enables us to understand the dysbiosis associated with specific diseases . PRODUCT PIPELINE We are developing a novel class of biological drugs designed to treat disease by restoring the function of a dysbiotic microbiome . CLINICAL TRIALS We have multiple active clinical studies to evaluate our microbiome therapy clinical candidates . . Experienced computational biologist with over a decade of expertise in next generation sequencing , expression analysis , comparative genomics , and systems biology . All views are my own .. Technologies :",
"Senior Staff Bioinformatics Scientist . . I am a computational scientist who specializes in microscopy , machine learning and computer vision problems . I have 8 years of experience in the biotechnology industry and provide leadership in informatics efforts to bring the sequencing platforms to market and 12 years working on image analysis problems I also have an extensive background in computer vision problems in cryo electron microscopy and machine learning problems in proteomics . I am an expert in C C , Python with expertise in multi threading , networking and vectorization . I have over 15 years of experience in software design , object oriented program and algorithm development . Specialties : Microscopy , computer vision , machine learning , microscopy , proteomics , C , C , Python and DNA sequencing .. Technologies : CryoEM",
"Graduate Research Assistant . Currently a graduate research assistant and PhD candidate at Iowa State University in the lab of Baoyu Stone Chen . I study structural biology and biochemistry of actin remodelers Wave and Wash , specializing in single particle cryo electron microscopy . . . Technologies : CryoEM",proteins;structure
"Scientist Drug Product Process Development . . I 'm a Chemical Engineer with 6 years of experience in process development and scale up of pharmaceutical drug products . I am passionate about process engineering , product development and production management . My intellectual curiosity has always driven me to venture into various avenues for solving a problem . I aspire to create a unique and reputable image for me in my field of interest . Specific industries of interest : Pharmaceuticals FMCG Energy Experience : Deep expertise in development of long acting injectable , microspheres , nano suspensions and liposomes Have experience in batch execution in GMP facilities , equipment validation and qualification URS , FAT , IQ OQ PQ activities Extensively worked on process optimization of pharmaceutical unit operations using Quality by deisgn QbD based approach , mechanistic modelling and process analytical tools PAT like FBRM , SOPAT , and PVM Quantitative and analytical mind well suited to make strategic decisions in fast paced environment Assiduous , affable and enjoy collaborative teamwork Education : Master 's in Chemical Engineering Academic projects : Spatial temporal modelling of spin coating on flat patterned substrates Multiphase validation of granular flow in STAR CCM Adsorbed natural gas ANG canister assembly for vehicular transportation Specialties Modelling software ANSYS , Visimix , MATLAB , DynoChem , STAR CCM . Technologies :",
"Anne McLaren Research Fellow . A transitionary role that gives me the opportunity to start my own research group studying human microbial communities using bioinformatics , mathematics , and microbial culture . . I am an independent group leader at the University of Nottingham studying the human microbiome using computational methods . I am always interested in new collaborations and opportunities ; please contact me at fiona.whelan nottingham.ac.uk .. Technologies :",
"Bioinformatician . . After working in the field for 3 years as a bioinformatic scientist at Salgomed , I have decided to continue my education at TU Munich working to receive a master 's degree in informatics . I have a computer science degree specializing in bioinformatics from UC San Diego . My strengths include working at the command line and using python to analyze and generate complex biological data and networks . My goal is to continue to use my expertise in the bioinformatic field to aide and contribute to the growing research and enterprises surrounding medical diagnostics , and treatment . . Technologies :",
"Assistant Professor . . Experienced professional with versatile skills in molecular , computational and structural biology . Competences comprise : Project and team management in interdisciplinary settings Excellent verbal and written communication skills Course planning and execution Consulting and supervision Patent prosecution Budgeting Specialties : Expert in viral infectious diseases High resolution cryo electron microscopy of challenging macromolecular complexes Modeling of molecular structure Molecular dynamics simulations Vaccine design Drug design Bacterial and mammalian cell culturing Protein expression purification RNA transcription purification Bioinformatics AFM on bio molecules Work including radioactive Isotopes Cloning techniques Statistical analysis Software method development and bench marking Data mining and digital signal processing . Technologies : CryoEM",proteins;structure
"Computational Biologist . Integrating metagenomics and metabolomics to identify metabolite pathways in microbiomes Developing methodology to automatically identify , score , and analyze synthetic modifications in viruses to determine if a virus is natural or engineered . Computational biology postdoctoral researcher with a focus on developing methodology for transcriptomic , genomic , and microbiome analyses . I work with human clinical , plant , mice , and microbial data across multiple omics layers .. Technologies :",
"Postdoctoral Associate . Postdoc in the lab of Andew Ward . Structural and biophysical approaches to cryo EM polyclonal epitope mapping EMPEM in the field of HIV vaccine development . . I am a researcher with versatile skills in molecular biology , biochemistry , biophysics , virology and protein chemistry from Dr. Irwin Chaiken Lab at Drexel University College of Medicine . I am also a family chef and enjoy cooking for my family and friends , and connecting with people . Skills : Biophysics surface plasmon resonance SPR Biacore3000 and S200 models , Isothermal Titration Calorimetry ITC , and ELISA . Protein science construct design , subcloning , site directed mutagenesis , PCR , protein expression in bacterial and mammalian expression system HEK293S and HEK293F , protein purification FPLC AKTA pure system with Unicorn 7.2 analysis software IMAC , , protein characterization SDS PAGE , electrophoresis , immunoblotting , analytical gel filtration , spectroscopic assessment . Cell culture techniques E.coli bacterial and mammalian cell culture HEK , CEM lymphoblast and HeLa , transfection , transient expression of proteins , cell based assays colorimetric , fluorometric , flow cytometry . Virology HIV 1 virus production , purification , virus validation , bioassays , virus passaging , inhibitor dose escalation assay . Software Biacore BiaEvaluation , Scrubber 2 , AKTA Unicorn 7.2 , UCSF Chimera v1.14.1 , Pymol , OriginLab , GraphPad Prism 8 , CompuSyn , Image J , MATLAB . . Technologies : CryoEM;ITC;SPR",antibodies;biologics;proteins;developing;interaction;structure
"Postdoctoral Researcher . Membrane protein structure and function , primarily using cryo EM methods . . I utilize structural biology methods to investigate membrane protein function Tamir Gonen Lab .. Technologies : CryoEM",membrane proteins;structure
"Senior Associate Scientist . . Experienced and enthusiastic research professional with a strong background in structural biology of novel bacterial pathogens , HIV 1 Envelopes , SARS CoV 2 spike , and their antibodies for vaccine design using x ray crystallography , cryo EM , and homology modeling . Demonstrated ability to work hands on , coordinate , and collaborate with experts of diverse backgrounds in structural biology , protein biochemistry , DNA and protein analysis , vaccine design , cell culture , binding analysis , computational biology , and molecular biology . Strong record of public speaking and written communication skills evident by 13 publications , 23 PDB depositions , 15 EMDB depositions , 7 international conference presentations , and 3 awards .. Technologies : Xray;CryoEM",antibodies;proteins;interaction;structure
"Technical Support Scientist . I provide technical support by phone and email for customers using Agilent 's automated electrophoresis instruments including the Bioanalyzer , Tapestation , Fragment Analyzer , etc . . I am a young , multi disciplinary biotechnologist with experience in bioinformatics , molecular biology , and biochemistry . A fast learner with a variety of skills from low level programming and data analysis , to cell culture and protein and DNA manipulation . I can fill wetlab roles , drylab roles , or roles requiring comfort in both .. Technologies :",
"Postdoctoral Scholar . . Postdoctoral researcher in Dr. Daniel Southworth 's lab at the Institute for Neurodegenerative Diseases , UCSF . I am an experienced biophysicist , currently working on studying chaperone protein complexes in Alzheimer 's disease using Cryo EM .. Technologies : CryoEM",idps;structure
"Principal Scientist Protein Therapeutics . Responsible for planning and executing multiple analytical and biophysical methods as SPR LSA , HPLC SEC MALS , DSF and other wet lab techniques . As a biophysicist and structural biologist , I have more than five years of experience in the isolation and characterization of soluble and membrane protein , and in my career I have successfully proven management , communication and organization skills as a member of a large research group Prof. Michel , Nobel Laureate and a student supervisor in the Max Planck Institute for Biophysics . In this regard , international scientific stays in renowned places have helped me to constantly improve these characteristics . I am constantly looking forward to apply my strong background in membrane and metallo protein biochemistry as well as my expert knowledge in the implementation of biochemical biophysical methods to an application oriented , creative and international environment .. Technologies : SPR;DSF",membrane proteins;proteins;characterization;interaction
PhD candidate . Knapp Group ; Drug development Development of degrader systems and molecular glues in mammalian cell lines . As a PhD student in the IMI project EUbOPEN and the SGC Frankfurt I am working on cellular systems for development and optimisation of PROTACS and other degraders as well as in crystallography for the identification and optimization of chemical probes and drugs . I strive to use my knowledge of synthetic biology to combine it with current cell biology methods to develop new technologies . Google scholar : https : scholar.google.de citations user jOQsOzoAAAAJ hl de . Technologies :,molecular glues;interaction;structure
"Principal Scientist . Protein Homeostasis Centre of Excellence Structural Biology Search for new modalities of targeted protein degradation and stabilization . I am a biochemist structural biologist with a focus on understanding disease associated protein functions through their structures . I am passionate about basic biomedical science research and therapeutics . A visionary with extensive research experience in diverse geographies Asia , Europe and North America over the past 12 years . I am a fast learner , a team player and adapt quickly to new work environments . I have gained extensive research experience in Protein RNA Biochemistry X ray Crystallography and Cryo EM . My expertise include cloning , protein engineering to protein purification , protein crystal structure determination and structure solution . I am experienced in biochemical and biophysical assay development and cell culture . Besides wet lab I am also trained in computer programming and Bioinformatics data analysis derived from proteomics and genomics . I am particularly interested in protein drug interactions and protein protein interaction pathways involved in cellular processes and diseases .. Technologies : Xray;CryoEM",proteins;small molecules;engineering;interaction;structure
"Associate Director of Bioinformatics . . I am an enthusiastic and versatile computational scientist and team leader seeking to advance biomedical research . I currently work on the Connectivity Map CMap project , where we have built the world 's largest compendium of gene expression profiles . The goal of CMap is to provide a lookup table for functional annotation of perturbagens and to thereby facilitate the discovery of relationships between drugs , genes , and disease . I also work on the PRISM project where we perform high throughput cell viability screens across hundreds of cancer cell lines , and leverage multi omic cell line characteristics to develop biomarker hypotheses . Specialties : Bioinformatics , Python , R , SQL , Linux , biological research , data collection analysis , team management , excellent communication skills . Technologies :",
"Principal Research Scientist Group Leader Discovery Biology . I lead a team of research scientists responsible for the hit to lead , and lead to candidate discovery and research phases for veterinary biopharmaceuticals and vaccines . In the therapeutic antibody space , my team is responsible for antibody discovery , species ation , affinity and effector engineering , lead optimization , and cell line generation . In the vaccine space , my team focus on viral reverse genetics , vector design , nucleic acid RNA and DNA vector platforms , and protein antigen engineering . We employ a wide variety of contemporary research techniques including structure based antigen design , antibody engineering , and synthetic biology . Fundamental applications of molecular biology , immunology , cell biology , and protein biochemistry are core to our work . . Group Leader , AH Discovery Biology . Technologies :",antibodies;biologics;carriers;proteins;small molecules;engineering;interaction;screening
"Genomic Applications Scientist . . I 'm currently a Genomic Applications Scientist at Oxford Nanopore Technologies , working on exciting long read sequencing applications projects . I 'm also a strong believer in education and promoting knowledge . I enjoy teaching as well as giving public talks . Main topics include algorithms , complexity , software , programming , and bioinformatics .. Technologies :",
"Research Biochemist . I am a senior scientist in the laboratories of Dr. David Agard and Dr. Nevan Krogan in the Departments of Biochemistry and Biophysics and Cellular and Molecular Pharmacology at UCSF . I study the structure and function of centrosomes , an organelle in mammalian cells that nucleates and organizes microtubules . Microtubules play vital roles in the movement of cargoes throughout the cells , and separating chromosomes when cells divide . I am also a team lead for protein purification in the UCSF Quantitative Biology Institure 's Coronavirus Research Consortium . I am also pursuing high resolution cryo EM structures of BRCA1 complexes important in breast cancer , and have worked on the Tau protein interactome important in neurodegenerative diseases . . I am a senior scientist in the laboratories of Dr. David Agard in the Department of Biochemistry Biophysics and Dr. Nevan Krogan in the Department of Cellular and Molecular Pharmacology at UCSF . We use biochemistry , cell biology , biophysics , mass spectrometry and structural biology cryo EM techniques to understand the structure function relationships of macro molecular machines . I am currently working on several projects : I study the structure and function of the microtubule nucleating machinery in the centrosome . Microtubules play vital roles in the movement of cargoes throughout the cells , and in separating chromosomes when cells divide . The centrioles within centrosomes are necessary for forming cilia . Both centrosomes and centrioles have important implications in human diseases such as cancer and ciliopathies . In response to the SARS CoV2 pandemic , the UCSF Quantitative Biology Institute QBI formed an international consortium QBI Coronavirus Research Group , or QCRG of researchers aimed at understanding how the virus interacts with and co opts processes in human cells . I am working as a protein purification team lead in the structural biology group of QCRG . Our goal is to use cryo electron microscopy and x ray crystallography to solve high resolution structures of viral host protein complexes . http : qbi.ucsf.edu qcrg structuralbiology . As part of the Cancer Cell Map Initiative , I am pursuing high resolution cryo EM structures of BRCA1 containing complexes that are important in breast cancer . I have also worked on the interactome of Tau protein in iPSC derived human neurons by mass spectrometry . Our goal is to understand how Tau protein is involved in neurodegenerative diseases such as Fronto Temporal Dementia and Alzheimer 's . . Technologies : Xray;CryoEM",idps;proteins;interaction;structure
"Associate Principal Scientist , Biophysics . . Proactive Biophysicist Dr. rer . nat . with profound expertise in characterising small molecule target interactions fragment based drug discovery lead development , protein protein and protein lipid interactions . Interdisciplinary project management of challenging protein targets and capability development . Mentoring in biophysical fragment screens in drug discovery . . Maintece and application of the following methods : NMR , SPR , TIRF microscopy , confocal microscopy , ITC , FCS , fluorescence spectroscopy , IRRAS , model membrane systems , cytotoxic tests , statistical analysis , biochemistry , microfluidics , clean room class 100 . Biological topics : diverse cancer targets incl small GTPases , neurotransmission synaptic vesicle fusion , amyloids . I enjoy solving problems analytically and am a motivated speaker presenter several poster prizes at international conferences . Additionally , I am able to coordinate and complete projects in a timely and concise manner . I care about data integrity and am consulting collaborators regarding their biophysical setups . . During my international scientific education in renowned labs in Germany , US , France and UK , I have had the opportunity to deepen my experience in scientific communication . I am an active member of the Publication committee of Biophysical journal . As I am eager to bring people together to openly discuss , I have recently organised a workshop Biophysics in Drug Discovery Not just a black box . The purpose of this meeting was to talk about technical issues when using Biophysical methods . It was fully organised but then had to be cancelled due to Covid . It has been postponed to 2022 . In my previous position , I also setup a new seminar series Know your method at the CRUK Beatson Institute teaching about the correct application and publication of diverse methods . During my PhD , I was involved in setting up a conference at the Max Planck Institute New Frontiers in Chemical Biology . I am known to be a proactive person who is eager to help and collaborate . Moreover , I am known to work with integrity and attention to detail on my projects . Data integrity is also very important to me . Therefore , I always try to improve and discuss data with my colleagues . . Technologies : ITC;SPR;NMR",idps;proteins;small molecules;interaction;screening
Scientist II . . . Technologies :,
"Laborleiterin Spezialistin Proteinbiochemie . Responsibilities : Management and organization of a wet lab of an interdisciplinary research group . Our group aims to develop new solid state NMR techniques on biologically relevant samples to enable structural investigations that crystallography or cryo EM do not provide . My main responsibility is to manage and scientifically supervise the research group members in their daily lab work 1 post doc , 5 PhD students , 1 master student , 1 technical assistant , 1 trainee . I assure the quality of samples and experiments , the implementation and compliance of lab safety regulations , the functionality of lab equipment as well as proper training of lab members . I also significantly participate in the recruitment and selection of new staff members . Beside these responsibilities I develop and optimize expression and purification strategies for different Amyloid peptides a , IAPP , SAA that play a crucial role in certain human diseases Alzheimer s Disease , type II diabetes , amyloidosis . In my current project I investigate the impact of glucose on the oligomerization state of a 42 . . I enjoy working at the interface of structural biology , cell biology and biophysics to gain knowledge of the function of challenging protein complexes . As a passionate wet lab person , I love to devise , realize and optimize experimental strategies and to find the best set of methods to answer scientific questions . My work style is structured , efficient , precise and persistent with distinct analytical skills and an eye for details . In addition , I am a proficient speaker and feel comfortable to present my projects , also in front of big audiences or to explain my work to non experts . As I am managing a multicultural and interdisciplinary research laboratory , I can draw on my excellent communication , organization and staff leadership skills . I am an active listener , a good motivator and like to train people with different educational backgrounds currently chemists and physicists and at different educational levels currently post docs to trainees . Despite the heterogeneity of our research lab members , I succeed to convey the importance of teamwork that now guarantees knowledge exchange , a supportive working atmosphere and smooth work flows . The lab members value me as a quick problem solver for both scientific problems as well as problems concerning the lab organization or equipment . For the first , I profit from my longstanding and extensive research experience . For the latter , my assertiveness , interpersonal and technical skills are a plus . I see need for and would like to apply my skills in the following areas : Research and development Process optimization Method development Quality control quality assurance Lab management Scientific or research services Education training Application support If my profile and skill set matches your requirements , please do not hesitate to contact me . . Technologies : CryoEM;NMR",proteins;structure
Principal Scientist . . Experimental biophysicist interested in protein dynamics .. Technologies :,proteins
Research Associate Biochemistry in Membrane Proteins . Production et purification de r cepteurs coupl s aux Prot ines G RCPG Production et purification de fragments d anticorps en vue de stabiliser le complexe RCPG Prot ines G tude structurale et fonctionnelle de complexes RCPG Prot ines G en cryo EM et SPR Cristallisation de RCPG en phase cubique LCP . Master de Biologie structurale int grative et Bio informatique Facult des Sciences de la vie Universit de Strasbourg . Technologies : CryoEM;SPR,antibodies;membrane proteins;expression;structure
Senior Research Fellow . . A dedicated and enthusiastic antibody engineering scientist with more than 10 years experience in developing antibody based therapeutics . . Technologies :,antibodies;developing;engineering
"EIPOD postdoc fellow . Time resolved and in cell cryogenic electron tomography ... no less . Hi , I am an interdisciplinary microscopy engineer with strong interest in methods development for structural biology and neuroscience . After graduating from the research engineering school ESPCI Paris physics , chemistry and biotechnology , I embraced biology with a bridging master Bioengineering Innovation in Neuroscience and a PhD in Neuroscience under the direction of Dr. Triller , in cole Normale Superieure ENS . During my PhD , I have developed 3D correlative light electron microscopy 3D CLEM approaches to quantify the morphological features of identified dendritic spines within intact neuronal circuits . I have set up workflows to combine confocal and super resolutive PALM microscopy with Transmission EM TEM and Serial Block face EM SBEM in brain tissue samples , and I collaborated with a postdoctoral fellow in ENS to constrain a model of signal compartmentalization in dendritic spines with the morphological data I collected https : doi.org 10.1371 journal.pbio.3001375 . I then moved to EMBL Heidelberg in fall 2020 to embrace structural biology and develop high throughput methods for cryogenic electron microscopy cryo EM an imaging approach that can provide native molecular structures with near atomic resolution . Emerging time resolved TR cryo EM technologies aim at capturing and imaging short lived reaction intermediates on cryo EM grids to determine the mechanism of essential biochemical events . Developing new , more robust methods of sample preparation will enable overcoming the intrinsic heterogeneity of TR cryo EM samples . During my stay at EMBL , I also develop workflows to improve the feasibility of cryo electron tomography cryo ET in large cells . My research will provide leverage to interrogate the structural basis of fast biological processes in intact cells . Personally , I have joyful and collaborative temper ; I am patient , rigorous and dedicated to whatever I do . I thrive in international environments and enjoy a culturally rich life wenn m glich . Thanks for reading ; feel free to contact me at olivier.gemin embl.de ; have a nice day and my best regards Olivier Gemin . Technologies : CryoEM",proteins;structure
"Senior Computational Scientist . Working in Joshua Levin 's group at the Stanley Center . Involves various projects related to the analysis of NGS data , particularly analyzing single cell RNA Seq data with the hope of better understanding neuropsychiatric diseases . . Computational biologist in the Stanley Center at the Broad Institute , with interests ranging from single cell analysis to privacy preserving genomic analysis .. Technologies :",
"Senior Scientist . Target Discovery Oncology Integrative Analytics group in the department of Genome and Biomarker Sciences Merck Research Laboratories MRL . . Bioinformatics and Computational Medicine researcher with a successful track record of integration , analysis , visualization , and interpretation of pre clinical and high throuput data . Expert in developing algorithms to apply machine learning , heterogeneous data integration , and , ' omic data and sizeable networks analysis to study complex genetic diseases e.g. , cancer and autoimmune disease , therapeutics response prediction , and computational functional genomics . Over fifteen years of working and presenting in highly multidisciplinary teams of MDs , computational scientists , and biologists . , and , writing articles and grant applications .. Technologies :",
"Research Fellow . . https : bkellman.github.io Main interests revolve around pediatric diseases , network biology , biostatistics , glycobiology , and metabolomics . Models should be simple and biologically constrained . . Technologies :",
"Research Technician . Perform routine laboratory maintenance and research activities such as electron microscopy sample processing and imaging , cryo electron microscopy grid screening , cryo sample preparation , negative staining and imaging . Perform administrative duties such as : laboratory management including maintaining reagents , glassware , and routine instrument management tasks ; assisting in record keeping ; and ordering supplies and billing . Provides technical and administrative support for a research project . Collects and enters data . Assists with preparation of manuscripts and other documents . Train and collaborate with incoming graduate students , postdoctoral fellows , and visiting researchers . . . Technologies : CryoEM",proteins;structure
"Scientist . . Experienced Scientist with a demonstrated history of working in the hospital health care industry . Strong research professional skilled in Life Sciences , Genomics , Cancer , Molecular Biology , and Sequencing .. Technologies :",
"Principal Scientist . . 15 years of experience in bioinformatics , genomics , and computational work , with 10 years of analyzing next generation sequencing data and 6 years at industry setting . Built industrial level bioinformatics pipelines in containerized images for analyzing DNA seq , single cell RNA seq , and genotype phenotype data , for both clinical and research purposes . The pipelines can be portable in both cloud computing and on premise systems . Experienced bioinformatician familiar with SAMtools , BWA MEM , GATK , Sentieon , DeepVariant , Parabricks , DRAGEN , STAR , Cell Ranger , PLINK , REGENIE , etc . Established scientific and technical collaboration relationships with strategic partners such as Sentieon and NVIDIA . Developed a Hi C analysis protocol for identifying long range DNA DNA interactions . The protocol handles mapping raw paired end reads , normalizing the data , integrating functional genomics data e.g. ChIP seq , DNase seq , etc . , and categorizing the predicted interacting enhancer promoter pairs .. Technologies :",
"Vice President , Head of Research . . I seek to improve diseases understanding at the molecular level and apply this knowledge to design , test , and develop novel therapeutics . I am passionate about finding biological problems with clinical applications and apply innovative technologies to bring therapeutics to the clinic . I believe in close partnership between biology and technology to jointly design , execute , and advance projects . I enjoy leading , mentoring , and developing a diverse team of talented scientists with broad areas of expertise including antibody engineering , protein chemistry , biochemistry , immuno oncology , structural as well as computational biology .. Technologies : CryoEM;SLS DLS;SPR;FRET",antibodies;developing;engineering;structure
"Associate Director , Computational Drug Discovery . Machine learning , predictive modeling , structural modeling , data science , cheminformatics . Data Science , Artificial Intelligence , Machine Learning , Big Data , Predictive Prescriptive Modeling and Analytics , Scientific Computing , Bioinformatics , R D Informatics , Cheminformatics . Computational chemistry . Computer aided drug design . ADMET modeling . Biophysics . Medicinal chemistry . Biomarkers . Gene expression analysis . Computational protein design .. Technologies :",
Senior Bioinformatics Scientist . . G scholar : https : scholar.google.com citations user Suh l7EAAAAJ . Technologies :,
Senior Scientist . . Experienced Postdoctoral chemist skilled in peptide synthesis and medicinal chemistry with 2 years research experience working in agriculture industry in Germany . Strong research professional with a Doctor of Philosophy PhD focused in Pharmacology and Peptide Chemistry from University of Auckland . I have experience with a multitude of biochemical and biophysical techniques for evaluating bioactivity and structure of new chemical entities . I am interested in the fast growing field of new modalities for targeting new therapeutic areas .. Technologies :,peptides;proteins;small molecules;characterization;structure
"Senior Scientist . Currently working on optimization and upscaling of bacterial pseudomonas fermentation in 2 L , 300 L and 5000 L bioreactor for production of lipopeptides . . Since 2002 , I have been working with yeast molecular genetics and cell biology , protein engineering , enzymology , development of recombinant protein expression systems using bacteria , yeast and mammalian cells as host , bioreactor fermentation , cell culture and facility , assay development GPCRs , enzyme , cell based and ELISA , purification and characterization of enzymes protease and carbohydrase , membrane protein aquaporin and monoclonal antibodies mAbs . With positive attitude , genuine technical interest and curiosity by nature , self motivated and engaged , with outstanding skills in implementation of new methods and technologies as well as further optimization , with demonstrated ability for interdisciplinary work and collaboration . Specific skills : 1 Pilot bioreactor fermentation of microorganisms and mammalian cells for recombinant protein production . 2 Downstream protein enzyme and mAbs purification , process development ultrafiltration diafiltration , IMAC , HIC , size exclusion and IEX chromatography on KTA Unicorn platforms . 3 Random , site directed gene mutagenesis , gene deletion and insertion into yeast genome . 4 Construction of various gene libraries BAC , YAC , phage , cDNA and SAGE library and genomic physical map . 5 Construction of protein expression vector plasmid specifically for bacteria , yeast and mammalian cells . 6 DNA Fingerprinting RFLP , AFLP , PFGE Analysis for genotyping . 7 Mammalian cell culture and stable cell line development using FACS . 8 Construction of DNA encoded combinatorial molecule library for drug discovery . 9 Protein peptide identification by SDS PAGE in gel trypsin digestion and LC MS MS . 10 DNA , vector and protein sequence analysis using vector NTI , SEQtools etc . . 11 NGS next generation sequencing sample preparation and large scale data analysis . 12 Microbial cell analysis under microscope and fluorescence microscope .. Technologies :",antibodies;enzymes;membrane proteins;proteins;engineering;structure
"Senior Research Associate . . 4 years professional in Research in Biotechnology , I work as a Research Associate in Drug Discovery at F star for 3 years focusing on the discovery , engineering , and characterisation of complex antibody constructs . Scientific and technically curious mindset with a dynamism approach to research project . Seeking to capitalise on my expertise in a role with the opportunity to lead a project and further develop my skills .. Technologies :",antibodies;characterization;engineering
Researcher PHD Student . Specialising in Cryo EM applications in material science . . . Technologies : CryoEM,
"Lecturer . T CADD Lectures 2x 45 min Topics 2020 2022 : PROTACs , mRNA and SM inhib . of SARS CoV2 , Cancer Immunotherapy , CAR T cells , Prodrugs Curing HCV Infection , HIV , Fluorine in Medicinal Chemistry , Treatment of Multiple Sclerosis , Treatment of Diabetes FXa inhibitor interrupted case study , All around TNFalpha , Kinase in Signal Transduction BTK ; JAKs TYK2 Inhib . introduction Drug Discovery . . Technologies :",molecular glues;developing
"Professor of Computer Science . . Faramarz Valafar is a Professor of Biomedical Informatics , Computer Science , and Joint Doctoral Programs in Epidemiology , Global Health , Electrical and Computer Engineering , and Bioengineering at San Diego State University . He is the founding Director of the Bioinformatics and Medical Informatics Research Center and its associated graduate program . He is the Principal Investigator of the Laboratory for Pathogenesis of Clinical Drug Resistance and Persistence http : tuberculosis.sdsu.edu His areas of expertise lie in Genomics , Epigenetics , and Systems Biology of Infectious Diseases especially Tuberculosis , as well as in data mining and pattern recognition using deep learning , especially in life sciences . He has received several multi year grants from the National Institutes of Health for projects in his area of work including a ten year grant from NIAID to study drug resistance in tuberculosis , as well as contracts from the local industry both as a consultant and as a subcontractor . His recent work includes proteomic , epi genomic , transcriptomic , methylomic , functional genomics of genetic dark matter , and systems biological medical data analysis for drug target identification and design , and functional elucidation of novel genetic proteomic products in drug resistant tuberculosis , cancer diagnosis , reconstruction of gene regulatory networks , prediction of effects of Hydroxyurea on sickle cell anemia patients , and automated structure determination of complex carbohydrates from their NMR and GC EIMS spectra .. Technologies : NMR",
"Staff Scientist . Comp bio . I am a multidisciplinary scientist with formal training and or research experience in medicine MD , anatomic and clinical pathology residency , artificial intelligence PhD , computer science , molecular biology , and neuroscience . I am passionate about increasing maximal healthspan by engineering novel therapeutics . I spend much of my free time exploring and evaluating the potential of different scientific research and domains .. Technologies :",
"Staff Scientist , Bioinformatics . . Mentoring and enhancing the computational skills of early career bench scientists and computational biologists enabling them to perform screening analyses . Developing and maintaining bioinformatics tools to analyze functional genomics screening data involving various modalities of CRISPR Cas such as CRISPRko , CRISPRa , CRISPRi and base editing . Developing analysis pipelines for various types of NGS data Developing tools to design and pick efficient guides for genome wide and custom libraries for screening with various existing CRISPR Cas modalities and to test and optimize new CRISPR Cas technologies . Benchmarking in house bioinformatics tools and analysis methods to published methods . Collaborating with software engineering and the operations team to plan and develop tools for teammates and external researchers . Interacting effectively with internal and external researchers from various backgrounds to help them with their computational needs . Presenting concise results of computational analyses to team members and collaborators .. Technologies :",
"Scientist II , Computational Biology . . . Technologies :",
"Research Assistant I Computational Biology , Nephrology . . I am a graduate of the University of Rochester and received a B.S. in Data Science with a concentration in Biology and a minor in Japanese . While a student , I gained computational experience in various sectors of biology including evolutionary genomics , clinical cancer research , and software development . When I 'm not debugging code or learning something new , you can find me reading fantasy novels , playing tabletop games , or getting lost in the woods .. Technologies :",
"Postdoctoral Research Fellow . Working with Professor Karl Deisseroth Neuroscience , Optogenetics . Areas of Expertise : Protein engineering , Computational protein design Rosetta suite , AlphaFold , Membrane proteins , Structural biology including drug binding , Channelrhodopsins , Ion channels , Mammalian protein expression and purification , Electrophysiology neuron and HEK cell patch clamping , Systems neuroscience , Protein biochemistry , Cell signaling , Cloning and Construct Design . . . Technologies :",membrane proteins;small molecules;engineering;interaction;structure
"Principal Scientist , Biochemistry , Biophysics Structural biology Lead . . Small molecules drug discovery , hit finding and optimization through structural biology and biophysics . Team and projects supervision . 13 experience in DNA binding proteins , complexes of proteins , membrane proteins enzymes , ion channels , GPCRs , transporters . . Technologies :",membrane proteins;nucleic acids;proteins;small molecules;screening;structure
"Senior Director , Bioinformatics . Head the Bioinformatics Group , provide leadership and strategies in Bioinformatics and Computational Biology for all stages of drug development from target discovery to in vitro and in vivo studies to clinical trials to drug approval and post marketing stages with a focus on discovery biological research to help understand various molecular mechanisms especially mechanisms of primary and acquired drug resistance , translational science medicine and molecular and companion diagnostics developments in oncology immuno oncology . Oversee pre clinical molecular data analyses , translational clinical biomarker data analyses and reporting , including preparation of biomarker data packages and reports for submission to regulatory agencies such as FDA and EMA etc . Vice Chair of the Pharmacyclics Science , Technology and Informatics Committee . Member of the Pharmacyclics Biomarker Governance Committee . Member of the Pharmacyclics Information Technology R D Applications Steering Committee . Member of the AbbVie Bioinformatics Steering Committee . Member of the AbbVie Early Development Advisory Committee EDAC for Apoptosis B Cell Signalling Emerging Science . . Subject matter expert and strategic leader in big data advanced analytics and data science with over 25 years of academic industry experiences specialized in statistical genetics genomics , bioinformatics computational biology , biomedical clinical informatics and biostatistics . Track record of high honors and achievements . Served as Grant Reviewer for National Institutes of Health NIH Bioengineering Sciences Technologies : Integrative Analysis for Translational Bioinformatics Section . Served as Grant Reviewer for National Science Foundation NSF Evolutionary Quantitative Genetics Division . Served as National Cancer Institute NCI Designated Developer and Mentor of the Microarray Repository Group in the Integrative Cancer Research Workspace of NCI Cancer Biomedical Informatics Grid caBIG . Served as National Cancer Institute NCI Designated Developer and Mentor of the Informatics for Proteomics Group in the Integrative Cancer Research Workspace of NCI Cancer Biomedical Informatics Grid caBIG . Extensive work experiences in various scientific and therapeutic areas , especially in oncology , immuno oncology , immunology , nutrigenomics , virology infectious diseases .. Technologies :",
"Research Fellow . . Experienced Research Scientist . Skills : Mathematical Modelling , Numerical Simulation , Computational biology , Data analysis ; Fortran , MATLAB , C , Python , Excel ; Image processing , 3D Reconstruction ; Finite Difference Method , Finite Element Analysis FEA , Parallel Computing ; Biomedical engineering , Electrophysiology , Biomechanics .. Technologies :",
"Sr Staff Scientist Automation . Automation Assay Development . I lead the automation team within the Assay Development group at Regeneron . My group develops fully automated ELISAs for the testing of preclinical and clinical samples for drug levels and immunogenicity . We have six state of the art integrated Thermo Scientific automation systems with Tecan liquid handlers . Chemiluminescence and MSD Meso Scale Devices are our detection platforms . We use Gemini and Evoware and Polara and Momentum scheduling software . I have written programs to automate and verify anti drug antibody ADA assays on the automation systems . I manage three automation associates . I am the study director for verification of all PK and ADA automated assays . I am responsible for writing SOPs and verification and qualification protocols as per GLP guidelines . My group is also responsible for the maintenance and verification of all lab equipment including readers and washers for the Assay Development and Clinical and Non Clinical Bioanalysis groups . I have 10 years of experience in the development , verification and execution of automated pharmacokinetic PK and immunogenicity ADA assays to support bioanalysis of clinical samples . In addition , I have about 10 years of experience in small molecule drug discovery research specifically in the automation of HTS assays . I have hands on expertise with a wide spectrum of biochemical , cell based and immunological assays and screening techniques , that are transferable between different therapeutic areas including oncology , infections and autoimmune disorders . I also have experience as an application scientist working on hardware and software development for instrumentation . Specialties : Automation of PK ADA assays , Tecan , Polara , ELISA , GLP , Biochemical cellular assay development , High Throughput Screening HTS , SAR analysis , Mode of action assays , enzyme kinetics , application solutions for instrumentations . Technologies :",small molecules;screening
"Bioinformatics Scientist Machine Learning . . Bioinformatics Data Scientist Specialties : bioinformatics , genomics , algorithm and methodology design and development , machine learning , deep learning , pattern recognition , data mining , data science , algorithm design , Bayesian and classical statistical inference , statistical and mathematical modeling , big data , regression analysis , classification , clustering , regularizer design , MapReduce , software engineering .. Technologies :",
Principal Scientist . . My primary goal is to use any kind of computational methods that help to get the meaningful biological insights and benefit therapeutical pipeline .. Technologies :,
"Visiting Research Fellow . Investigating exercise in relation to disease prevention and reducing age related complications Overseeing a multi disciplined study including exercise physiology , genomics , and computational biology bioinformatics by investigating cell free DNA and exercise . Skills utilized : set up and manage clinical exercise studies , hired and managed research assistants , analyzed and communicated research results through journal publications , writing manuscripts , writing grants . An exercise biologist who enjoys the science and application . I 'm equally comforatable doing research as a compuational biologist investigating muscle metabolism and training collegiate athletes or the general population . My scientific exepertise is in sports nutrition and exercise biology and metabolism . My clinical expertise is training and developing high school and collegiate athletes and the general populaton . Current Research Focus : Exercise in relation to disease prevention and reducing age related complications . Specialties : Experience with athletic , post rehab , and general populations Expert in muscle energetics and amino acid supplementation . Technologies :",
"Principal Scientist , Clinical Translational Science . Provide Scientific expertise in Sobi Theuraputic areas and engage in academic collaborations . Currently I work as Principal Scientist in the Clinical Translational Science Department where I provide scientific expertise both to our projects and in evaluation of external projects . I also engage in academic collaborations to advance scientific knowledge in Sobis therapeutic areas . Previously I worked as a Project leader for research Projects and had a scientific lead role in development Projects . I was also involved in protein engineering where I contributed with structure based computational techniques and knowledge on construct design . In my previous role as a senior scientist in computational biology my responsibilies included construct design , regarding fusion partner selection , mutagenesis for selected properties such as solubility , expressability and stability . Specialties : Computational Biology : Protein homology modelling , Sequence based methods , MD simulations , Sequence database administration , Protein protein docking .. Technologies :",
"Senior Laboratory Research Scientist . . A highly motivated and hard working individual with an impressive range of Biology and Computing skills , including BSc Hons and Ph.D. qualifications in the field of Bioinformatics . An internationally certified Shotokan Karate Instructor , and an internationally certified PADI Open Water Diver . I have a passion for travelling , having spent the last couple of years travelling independently to over 18 countries , including 10 weeks backpacking across India . I am an avid volunteer worker , which has included poverty alleviation in the Dominican Republic as well as working as an unpaid Karate instructor for the last decade . During my mid teens I volunteered at the Wellcome Trust Sanger Institute in Hinxton . I currently work as a bioinformatician at the UCL Cancer Institute , analysing 3C , UMI 4C and Hi C data , with the aim of understanding chromatin structure .. Technologies :",
"Associate Professor . Research Membrane protein structural biology and teaching PhD MSc undergraduate students , . My main interest is to understand the details of structure function relationship of proteins . In the past i have worked on elucidating structures of protein : protein complexes and enzymes . My current and probably future interest is in the field of membrane proteins , more specifically secondary active transporters , and their role in health and disease .. Technologies :",membrane proteins;structure
"Principal Scientist . . A highly skilled , independent and self motivated scientist with interdisciplinary background and excellent communication skills ; 5 Years of pharmaceutical and medical device industry experience in analytical method development and formulation development of small molecule protein peptide nucleic acid based therapeutics , anchored by a strong publication record . TECHNICAL SKILLS : Expertise in analytical method development and qualification for identification , quantitation and impurity profiling of small molecule , protein , peptide and nucleic acid based therapeutics using multiple techniques : Chromatography : HPLC UPLC with UV , RI , CAD , ELSD , MALS and MS detectors for reversed phase , HILIC , SEC , IEX and IP RP based LC separation ; Mass Spectrometry : native MS , ion mobility MS , LC MS MS and ICP MS ; Electrophoresis : CE and cIEF ; Spectroscopy : UV vis , FTIR , fluorescence microscopy , fluorometer , CD and DLS ; Calorimetry : ITC , DSC , TGA and DSF ; Proficient in instrument related software and Python scripting ; Skilled in automated data processing and statistical analysis ; Proficient in pre formulation and formulation development of small molecules and biologics for various dosage forms oral liquid , liposome and polymeric microsphere using QbD and DOE approaches ; Experience in protein purification , protein biophysical assay development and hemostasis assay development ; Experience in regulated GLP and GMP environment ; Excellent communication and technical writing skills ; Strong project management capability in cross functional and multi task environments . Technologies : ITC;SLS DLS;DSC;DSF",biologics;nucleic acids;peptides;proteins;characterization;formulation;interaction
"Postdoctoral Researcher . Electron microscopy , CRYO EM , materials science . . Technologies : CryoEM",
"Staff Scientist , Bioinformatics . . I have several years of research experience encompassing life sciences , mathematics and informatics at premier institutions in collaborative , multidisciplinary environments . While I count informatics and computational skills as my core expertise , my abiding and overarching interest however , remains biology . Over the years I have employed bioinformatics and statistical techniques to make biological sense or facilitate biomarker discovery in RNA Seq , GWAS , Metabolomics and Proteomic datasets . I am fascinated by cloud computing and the AI ML frameworks and continue to build on my expertize in these areas through work and certifications such AWS 's Developer and Big Data speciality certifications and Google 's TensorFlow certification . In my current position at ThermoFisher Scientific , I am spearheading a project that utilizes Next Generation Sequencing as a Quality Control tool to build the next generation of Microarrays .. Technologies :",
"Application Scientist Research Professor . The Pennsylvania State University Department of Biochemistry and Molecular Biology Assistant Research Professor Galaxy Project https : galaxyproject.org https : usegalaxy.org https : help.galaxyproject.org https : github.com jennaj https : galaxyproject.org people jennifer jackson https : science.psu.edu bmb people jlj22 https : biostar.usegalaxy.org retired archive . Scientist , Manager , Optimist , Innovator . Technologies :",
"Principal Scientist . Department of Biophysics and Injectable Formulation . Research , Novo Nordisk . I have experience with a broad range of biophysical and biochemical techniques to study peptides , proteins and in particular antibodies , with the primary focus on physical and chemical stability . My interests and project responsibilities have included molecule screening , protein engineering , formulation development , investigation of mode of action , technology development , external collaborations , project management , and patent processes . Currently I work as a principal scientist with focus on biophysics and formulation in early discovery projects .. Technologies :",antibodies;biologics;characterization;engineering;formulation;stability
Computational Biologist . . . Technologies :,
"Consultant . . Microbiologist with over 9 years experience in Pharma Healthcare related fields . I want to be in a fast paced environment , working with people as part of a team , where I can combine my scientific knowledge , science communication and problem solving skills , gained during my PhD , with my business mindset . Innovation and Leadership Activities : Consulted with department to drive program innovation through data analysis and market research . Seasoned mentor and active team player Marketed the department through social media and managed Microbiology Graduate Program Social Media Team Instagram : UGAMibocrograd , Twitter : UGAMicroGrad , Facebook : UGAMicroGrad Highly skilled in Microsoft 365 Suite , including Teams , Outlook , Forms and OneDrive . Networked with University resources to execute a Sexual Harassment Workshop targeted at STEM graduate students Lobbied for and negotiated improved graduate student health insurance Research Experience and Interests : Microbial physiologist with background in natural product discovery and prokaryotic primary metabolism Active member in graduate community , improving graduate student life , with a focus on communication and transparency Seven years experience with prokaryotic Iron homeostasis Trained in biochemical techniques and instrumentation Proficient in molecular biology techniques . Experience in grant writing 11 semesters of teaching experience Research Techniques : Cryo Electron Microscopy Protein Purification Protein Crystalization Cell Culturing of Streptomyces , Mycobacteria , Staphyloccus , Baccillus species and E. coli HPLC Transmission Electron Microscopy UV vis Spectroscopy Differential Scanning Fluorometry Isothermal Calorimetry Western Blotting Cloning Gibson , PIPE , Traditional . Technologies : CryoEM;ITC",
"Vice President Research and Early Development . Leadership of the LEO Research unit From target identification to human PoC. Strategy and execution of disease research and drug discovery . New medicines based on small molecule drugs , biologicals and regenerative medicine technologies . Latest activities : Relocation to and operating 6 mth out of Cambridge MA Setting up LEO Rare Disease activities operating out of San Francisco , CA . Drug discovery leadership , Fast to PoC , Immunology , External innovation platforms 20 years with biomedical research 18 years with pharmaceutical R D in the private sector 14 years with management and leadership 200 employees 10 years with portfolio and governance board positions Thorsten 's experience spans broadly across research with significant experience from drug discovery and early drug development . Thorsten 's key expertise sits in immune disorders and inflammatory diseases , especially skin diseases and dermatology , where he also brings business development M A expertise and more recently gained commercial exposure as well . Most of Thorsten 's operations have been conducted out of Copenhagen Denmark but he has a broad network of global collaborators and in 2019 relocated 5 months to Boston Cambridge US to extend his international collaborations . Thorsten and his team has over the years in LEO brought 12 molecules into clinical testing with the most progressed reaching phase 3 . On top 2 new products based on reformulation has been commercialized . Key words are : Target identification and validation Small molecule , antibody drug discovery , regenerative medicine Translational experimental platforms linking biochemistry , preclinical animal models and PoC clinical testing Repositioning , reformulation and life cycle management Business development , R D partnerships and project acquisitions External innovation Rare disease drug development Patent prosecution and patent litigation .. Technologies :",antibodies;biologics;small molecules;developing
"Vice Chair . . I 'm a statistician with a focus on medicine , biology , and statistical computing . I have extensive experience in research and analytics for large scale modeling , variable selection methods , and biostatistics . I 'm interested in biologic or medical problems that do n't have an easy or obvious solution . I enjoy teaching , both one on one and classes . Specialties : Proficient : R , SAS , Matlab , LaTeX , high dimensional analytic methodologies , human genetics Competent : Stata , Perl , HTML , CSS , C , Java , cardiology . Technologies :",
"Associate Scientist BioTD AD Separations and Biochemistry . . Enthusiastic hard working individual currently working in clinical release and stability analytical development . Routinely performs analytical testing using A280 and SoloVPE spectrophotometry and capillary electrophoresis SDS . Competent with software 's including LIMS , Empower , Smart QC and Excel . Schedules weekly team testing in line with business needs . Active member of the 6S team and environmental health and safety team . . Other experiences include a 6 month wet lab research project in the Conway Institute UCD focusing on phage display and discovery of novel antibody fragments against a target antigen . Carried out protein expression in bacterial hosts to obtain the target antigen followed by successive rounds of phage display on immunotubes to isolate antibody fragments from a semi synthetic library . . Previously undertook a 5 month industrial placement as a member of the process optimisation group in TS MS in Eli Lilly and Company . Performed bench scale reactions and in process testing for process validation studies and documentation . This involved organic synthesis in a step by step scaled down reaction which was monitored via HPLC and GC analysis at several stages throughout the process . . Technologies :",stability
"Senior Scientist . . Experienced Research Scientist with a demonstrated history of working in the biotechnology industry . Highly skilled in peptide drug design , peptide synthesis and purification , Liquid Chromatography Mass Spectrometry LC MS , protein expression and purification , crystallization and biophysics . Strong professional with project and team coordination experience . . Technologies :",peptides;proteins;characterization;expression;structure
"Principal Scientist , Bioanalysis . . PhD Biochemist with over 10 years of experience in early and late stage of drug discovery development in oncology and metabolic diseases using molecular biology , cell biology and protein chemistry techniques Extensive background in cancer biology lung , prostate , lymphoma , multiple myeloma Significant experience in NASH NAFLD Fibrosis Strong leadership quality as demonstrated by independently leading several key drug discovery projects Demonstrated mentoring experience with junior scientists as direct reports to meet the project goals Established track record in successful grant and patent applications Significant experience in designing small molecule screening strategies , executing screening platform , and directing functional studies toward target validation Strong expertise in developing cellular models to understand Mechanism of action MOA in relapsed and refractory disease progression Contribute biomarker identification and validation strategies to build drug discovery programs in the field of targeted oncology with small molecules approach Exceptional oral and written communication skills patent application , SOP writing , technology transfer , journal publications , and conference proceedings Strong interpersonal and problem solving skills with ability to work independently in multi disciplinary teams Working experiences with functional areas of drug development that include biology , medicinal chemistry , and in vivo pharmacology and toxicology Experienced in cell based High Throughput Screening assay method development Working experiences with CROs to design vectors and plasmids or biochemical methods development for enzyme assays Deep understanding of GCP and regulatory protocols and requirement to ensure compliance Highly organized and experienced in working in a fast paced , matrixed , cross functional environment Specialties : Oncology , Biomarker Identification and Validation , Cell Signaling , Cell Based High Throughput Screening Assay , Immunology . Technologies :",small molecules;screening
"Senior Scientist Group leader Antibody and Protein Engineering . SECTION : . Biologics Research . ROLES , RESPONSIBILITIES EXPERTISE : . Managing up to 3 Molecular Biology Labs with 8 technicians and responsible for all molecular biology related work packages . Responsible for engineering , humanization of antibodies and bispecific molecules . Successful project leader of cross functional antibody discovery and optimization projects in the indication areas Ophthalmology , Haemophilia , Inflammation and Lung diseases . Leading a cross functional team to establish a bispecific antibody platform including manufacturing , analytics and cell line development . Monitoring the budget of external contracts covering molecular biology related cost centres DNA synthesis , primer , sequencing . Evaluation of external providers for molecular biology related services and implementation in standard processes . . Technologies :",antibodies;proteins;engineering
". . Scientist PhD , In vitro , Biology , Molecular , Pharmacology , Signal transduction , Mechanism of action , Human biology , Medicine , Cell culture , Laboratory , Bioassay , Innovation , Troubleshooting , Documentation , Drug discovery , G protein coupled receptor GPCR , Research , Development , R D , Diabetes , Obesity , Screening , Experiment , Analysis , Pharmaceutical Industry . Technologies :",membrane proteins;developing;screening
"Senior Principal Computational Biologist . . I received my PhD degree in the fields of Bioinformatics and Computational biology with strong background in both biology and computer engineering . I have research experiences in various biological problems , including adaptive evolution of haloarchaea , statistical simulation of chemical reaction system , splicing related tumorigenesis , with specialized interest and expertise in genome wide and transcriptome wide analysis of pediatric adult cancer biology and immuno oncology . I also have strong experiences in computational applications including various state of art algorithms , dealing with large scale biological data , especially NGS data including WGS , WES , RNASeq , scRNASeq , Chipseq , ATACseq , WGBS etc . , experience with HPC clusters and being proficient with most popular programming languages , experience in large scale data standardization , integration and data mining .. Technologies :",
"Member of the Board , Division of Medicinal Chemistry and Chemical Biology . The DMCCB comprises about 750 scientists interested in medicinal chemistry , chemical biology and related fields of research . It organizes scientific events and interacts with other country organizations to represent the Swiss medicinal chemistry and chemical biology community . Co organized the ' Basel Symposium ' 2022 on Intrinsically Disordered Proteins as Drug Targets . . Experienced molecular modeler and computational scientist contributing in a goal oriented and ambitious environment . Started with managing IT infrastructures and developing customer oriented software solutions . Over the last 9 years I have been deeply involved with hands on computer aided drug design projects on lectins , GPCRs , proteases , short chain dehydrogenases , CYP450s , nuclear receptors and microbial enzymes . The skill to explain highly complex matters in an understandable way is what profiles a modeler that excels . . Technologies : Xray;ITC;SPR;NMR",
"Group leader , Max Planck Institute of Biophysics Frankfurt am Main , Germany . Research focus : Antibody and obody technology , Yeast Display , eukaryotic membrane proteins , G protein coupled receptors , transport proteins , ABC transporter , cryoelectron microscopy . Methods development : Transport assays for ABC transport proteins using fluorescence activated cell sorting FACS , high yield fermentation strategies for methylotrophic yeast Pichia pastoris , scaffold design for obodies . Staff responsibilities : 3 7 PhD students , 2 technical assistants , 1 postdoc . . I am a passionate scientist with a focus on antibody technology and eukaryotic membrane proteins . In addition to my leading position in the laboratory , with the training of Ph . D. and diploma students , in recent years I have worked as a consultant for companies in the biotech industry or as their cooperation partner . The current pandemic has shown how important antibodies can be to fight diseases . Besides conventional antibodies e. g. IgG 's , so called single domain antibodies nanobodies are becoming increasingly important . At the Max Planck Institute of Biophysics , I was able to set up a nanobody platform Yeast Display that allows us to select high affinity nanobodies against membrane and soluble proteins within a few weeks . As recently shown , thanks to these nanobodies , we can now solve structures of small membrane proteins by cryoelectron microscopy . In addition to the classical nanobody formats , I am developing larger scaffolds that can be used for color labeling of target proteins besides their use in structural biology . . I am convinced that in the near future , in addition to research applications , antibodies and their derivatives will play an increasingly important role in the development of biotherapeutics . . My other passion is the research of eukaryotic membrane proteins . These molecules play a crucial role in all aspects of life . Among their important tasks in the cell are communication , production of energy equivalents , enzymatic activities , and the import or export of various substances . Although membrane proteins make up only one third of the human genome , they are targeted by more than 60 of the drugs on the market . Due to their low natural abundance and difficult handling , the structure and function of many of these molecules have not yet been explored . . In addition to G protein coupled receptors and their associated G proteins , I am also interested in eukaryotic transport proteins . These transporters play a major role e. g. , in fighting cancer cells or pathogenic yeasts . Recently , we were able to solve the structure of an ABC B transporter and characterize its transport behavior with different substrates publication submitted . . Technologies : NMR",antibodies;membrane proteins;characterization;structure
"Senior Scientist , Biophysics . Siduma Therapeutics is the latest Craig Crews company leveraging its extensive heterobifunctional molecule discovery and development expertise towards a new , disruptive therapeutic platform targeting disease causing proteins . . Senior Scientist , Biophysics , Siduma Therapeutics , Inc. Siduma Therapeutics is the latest Craig Crews company leveraging its extensive heterobifunctional molecule discovery and development expertise towards a new , disruptive therapeutic platform targeting disease causing proteins . Postdoctoral fellowship , Yale University ; PhD in Biophysics , University of Michigan . Two fold research interests in biophysics and structural biology based approaches to characterize molecular bases of macromolecular recognition events , namely protein protein interactions PPIs , and rational design and development of small molecule inhibitors and heterobifunctional small molecule PROTAC ligands against difficult to prosecute pharmacological targets PPIs , transcription factors , epigenetic complexes implicated in human disease .. Technologies : Xray;NMR",molecular glues;proteins;small molecules;interaction;screening
". . I hold a PhD in Molecular Biology from Aarhus University . During my PhD I have studied the structure and function of a protein involved in ciliary transport of membrane proteins . My PhD study has given me extensive knowledge and expertise in molecular cloning , protein expression and purification , biochemistry , and structural biology . In addition , I have a good understanding of many fields of Molecular Biology and I have a strong ability to learn new skills and gain knowledge within new fields . I have a sense of quality and a structured work approach which is beneficial in quality related positions . I am a good listener and throughout my studies I have gained good collaborative skills through internal as well as external collaborations . I am curious as person and I like to expand my knowledge . I am therefore very positive towards new challenges .. Technologies :",membrane proteins;structure
"Career Development Fellow . . As a theoretical biologist , I am passionate about evolution and development , but I am also broadly interested and enjoy applying my analytical skills to a variety of research questions and programming problems . Besides doing research , I enjoy learning new skills and teaching .. Technologies :",
"Lecturer in Bioinformatics . . My background consists of strong programming skills as well as significant training in genomics and molecular biology , which allow me to contribute in multidisciplinary areas such as bioinformatics and computational biology . My research focuses on deriving mechanistic insights through data analysis , integration and interpretation of omics data , with the aim to understand how genetic changes influence gene regulation and affect complex phenotypes . My principal aims at Cardiff University are to identify potential molecular targets for therapeutic intervention in schizophrenia and other psychiatric disorders , in collaboration with Takeda Pharmaceutical Company Limited . At Imeprial College London my principal focus was to investigate the precise mechanisms by which NF B promotes malignant cell survival in Multiple Myeloma and Diffuse Large B Cell Lymphoma and how NF B controls bioenergetic pathways participating in Colon Cancer pathogenesis . During my Ph.D. in Biocomputing group at Sapienza University of Rome , I had the opportunity to analyse several experiments produced by Next Generation Sequencing technologies and to develop specific tools able to improve some critical steps of the analyses , solve problems derived by system complexity and provide user friendly results . I also dealt with different biomedical problems such as the contribution of long non coding RNAs in muscle differentiation , the identification of molecules involved in HBV replications or the generation of a high resolution profile of antigen specific antibody repertoires . Before starting my Ph.D. , I worked for two years in the Department of Biology and Cellular and Molecular Pathology at University of Naples Federico II , where I gained experience in the development and management of biobanks as well as in the design and statistical analysis of observational studies . Meanwhile , I further advanced the work started during my master dissertation on simulating models of gene environment interactions in populations affected by complex diseases . . Technologies :",
"Senior Staff Scientist . . A computational scientist interested in solving challenging problems at the interface of life science , Chemistry , Physics , and computational sciences . Strong aptitude for public health problems including single molecule biophysics to multiscale modeling , drug discovery delivery , membrane proteins , enzymes , carbohydrates infectious diseases , computational immunology , computational vaccine design ; Specialties : Extensive experience in Computational Biomolecular dynamics , molecular simulation packages Gromacs , NAMD , LAMMPS ; Combining Science and Engineering : Computer aided Design of novel bionanomaterials . High Performance Computing ; cloud computing . Informatics and Analytics : structural Bioinformatics ; NextGen Sequencing , chemical informatics , Data Science .. Technologies :",small molecules;developing
Postdoctoral Research Fellow . Structural characterizations of DNA polymerases . Cryo EM studies of macromolecular complex involved in DNA repair and replication . . . Technologies : CryoEM,nucleic acids;proteins;structure
"Sr . Director , Computational Biology . . Currently leading a cross disciplinary team of scientists working to implement , generate and analyze data from state of the art immune profiling technologies in preclinical , translational and clinical space in the field of Immuno oncology . Extensive experience with data generation and analysis of next gen sequencing technologies epigenetics , DNA , RNA for both bulk and single cell , flow cytometry , cyTOF and multiplex Immunohistochemisty IHC Immunoflourescence IF . Computational Biologist by training with significant expertise in development of fit for purpose cross platform analytical methods and solutions aimed at answering biologically relevant questions and hypotheses . Experience in target identification and validation for preclinical research and identification of biomarkers for Translational Medicine programs by integrating large scale molecular and clinical data Specialties : Computational biology bioinformatics , translational research , target discovery and validation , biomarker identification and implementation , data mining , algorithm development , multidimensional data analysis , RNA seq , single cell RNAseq , cyTOF , multiplex IF . Technologies :",
"Senior Staff Scientist . . Computational biologist with 20 years of research experience in genomics , molecular biology , genetics , epigenetics , bioenergy , plant development , and plant pathology . 10 years of experience in Next Generation Sequencing technologies . Currently supporting product development in the areas of genomics , cancer biology , and infectious disease . Experienced in the development of lab protocols ranging from experimental design to wet lab procedures and analysis pipeline development to enable new methods and new biological insights . Highly interested in combining computational biology , genomic , genetic , and synthetic biology approaches for industrial biotechnology solutions for bioenergy , agriculture , and human health .. Technologies :",
"Scientific coordinator Project manager Protherwal . Scientific coordination of Protherwal , a research project that brings together with IBA teams from all the French speaking universities of Belgium in radiophysics , physics , biology , chemistry , imaging , and medicine . This project is funded by the Walloon Region . Project manager for the creation of a proton therapy center in Charleroi dedicated to research and patient treatment . . A seasoned project manager and scientist with proven scientific knowledge in clinical and preclinical imaging , with strong experience in strategic and operational management of multidisciplinary projects , highly focused on providing the most tailored and comprehensive services to biotech companies and academic partners . . Offering leadership and expertise in collaboration management , project writing , project planning and budgeting , service pricing , procurement and installation of large high tech equipment . With specific experience in characterizing the therapeutic value of new molecules from peptides and antibody fragments to cell therapy using various imaging approaches , study design , implementation and optimization of clinical and preclinical imaging protocols , image and data analysis , statistics , evaluation and reporting . Guided by values of respect , responsibility , integrity , and scientific rigor , open to innovative ideas and new collaborations . . Technologies :",
Principal Scientist II . Chemical Biology Therapeutics Protein Sciences . Lead for membrane protein targets . Driving technology development and structural biology efforts . Drug Discovery Drug Delivery Technologies Molecular Biology Structural Biology Membrane Proteins Transcription Factors Protein Complexes Biophysics Photography . Technologies :,membrane proteins;proteins;screening;structure
"Doctoral Researcher . . I am a PhD student at ETH Z rich and Paul Scherrer Institute with experience in structural biology , particularly Cryo electron microscopy , cryo electron tomography , correlative light microscopy , confocal light microscopy FRAP , FRET and biochemistry working mostly with mammalian cell systems . I am particularly interested in cellular signalling and intercellular communication . . Technologies : CryoEM;FRET",proteins;characterization;structure
"Principal Scientist Head of X ray crystallography . Continue focus on the structural biology of membrane protein GPCR and GPCR G protein complexes . I am responsible for all X ray crystallography activities in the company , driving multi target collaboration with external clients , managing a team of scientist and the application of serial crystallography at synchrotron and XFEL for drug discovery projects . I am a structural biologist with 15 years industrial experience . I have worked in various pioneering biotechs , and covered research areas including fragment based drug discovery , structure based drug design , membrane protein GPCRs G protein complexes and serial X ray crystallography . Currently responsible for all crystallography activities in the company , driving multi target collaboration projects with external clients and managing a team of scientists . . Specialties : Protein crystallography . Protein engineering . Construct design , expression and purification . Biophysical analysis of protein and protein ligand interaction . Membrane protein GPCR expression , purification and crystallization Lipidic Cubic Phase , bicelle and vapour diffusion approach . GPCR G protein complexes . Serial crystallography . Synchrotron data collection and processing . . Technologies : Xray",membrane proteins;proteins;small molecules;expression;interaction;structure
"Senior Research Development Scientist . . I am a scientist , and most of my career has been conducted at the University of Aalborg DK . My current research is focused on interfacing genetically modified proteins with cyclodextrins or cyclodextrin polymers , for the purpose of site directed photo covalent protein immobilization on surfaces or photo labeling of proteins . Genetic engineering is based on the incorporation of non natural amino acids . Particular emphasis is placed on recombinant antibodies scFv . The project is aimed at 1 understanding the fundamental aspects of protein CD interactions ; 2 to develop a method for protein photo coupling to surfaces modified with cyclodextrins or modified cyclodextrins for biosensors and molecular diagnostics . My other research interest is the study of a class of small cytosolic proteins involved in transport and signaling of long chain fatty acids , namely fatty acid binding proteins FABP . The research has been focused on understanding some of the biophysics stability , self aggregation of the brain type , FABP7 , and its function s in glial cell biology . Specialties : Protein chemistry , Protein Recombinant Expression , Gene Technology , Biochemistry , Analytical Chemistry , Spectroscopy , Chromatography , Surface science . Technologies :",antibodies;carriers;engineering;interaction;stability
"Postdoc researcher . 1 . Recent postdoc research at UCSF focused on the study of enamel matrix protein self assembly and the protein mediated mineralization processes . Via tissue studies on a transgenic mouse model , we successfully identified unique functional amyloid nanoribbons to be the templates that guide enamel apatite nanofiber formation . In vitro amelogenin nanoribbons were successfully constructed and proved to maintain the ability to guide oriented apatite mineralization . These findings provided deeper insights into the complex enamel formation mechanisms and can also inspire fabricating enamel like materials with advanced mechanical properties . Related studies achieved 2 paradigm shifting research papers 1 first author paper as from the cover publication in The Proceedings of the National Academy of Sciences PNAS . and 2 critical review papers 1 first author as well as a NIH RO1 funding of 3.5 million dollars over 5 years . 2 . Ongoing research focused on pathological biomineralization of renal calculi . Our study provides novel insights into kidney stone formation where the interplay between microbe and host immune response produced an organic network facilitating unwanted stone deposition . The ' double edged sword ' effect of the immune response was demonstrated in pathological biomineralization context for the first time . . Experienced researcher with 6 years of post doctoral training in biochemistry and biomaterials . Development and fulfillment leader of new and existing biochemistry projects with an ability to utilize state of the art technologies for delivering high quality , rigorous results . Diverse research background including protein chemistry , protein engineering , protein assemblies , and protein inorganic interactions . Top down thinker with ability to integrate individual research programs into grander biological context . Strategic decision maker based on thorough and factual information research . Ability to manage project execution with specific steps and detailed planning . Value emotional stability and mental clarity .. Technologies :",idps;proteins;characterization
"Senior Research Associate . Biochemical Analysis of antibody products in early CMC . Characterization of antibody candidates with formulation , high concentration and time course stability studies . Assay development and qualification . Analytical techniques UV Vis , HPLC , CE SDS , DLS , Visual Inspection , Viscometry , Biacore SPR . Biochemist MSc currently working on Biochemical analysis of antibody products . Artur graduated with an MSc and BSc in Biochemistry from the University of Porto , Portugal . He has worked in labs studying Neurodegeneration and Cancer , using cell culture , cloning , recombinant protein expression , protein purification , protein QC , cell and protein assays . He 's competent with FPLC systems Akta and Unicorn liquid chromatography techniques ProA , IEX , HIC , SEC , and HPLC Waters UPLC and Empower . keywords : Protein Science , Biotherapeutics , Chromatography .. Technologies : SLS DLS;SPR",antibodies;characterization;formulation;interaction;stability
"Chemist . Development and validation of new analytical methods Participate in cross organizational project meetings Transfer of analytical methods to QC and production sites . Highly structured and self motivated analytical chemist with a biophysical background . 5 years of research experience with the biotech industry . Strong background in the development , validation and implementation of bio analytical methods . A proven team player able to work independently . First class problem solving skills . Experienced in design and statistical analysis of experiments . Solid IT knowledge with medium level programming skills . Skills : protein chemistry and stability , enzyme assays and kinetics , mathematical modeling of enzyme kinetics , structure activity relationships , protein purification , chromatography HPLC , IC , assay development and implementation , biosensor technology , biophysical characterization of liposomes and proteins , calorimetry in the biophysical science , electroanalytical chemistry . Technologies :",carriers;enzymes;proteins;characterization;interaction;stability
"Doctoral Researcher . My project deals with characterizing SPT6 and its role in RNAPII transcription . For this , I used Auxin Inducible Degron system which achieved acute and targeted depletion of the protein of interest . First , I established AID tagged SPT6 expressing U2OS knockin cell line with CRISPR Cas9 system . Further , we could achieve complete depletion within 4 hrs . Next , we characterised the nascent transcription 4sU seq , DRB 4sU seq , RNAPII occupancy ChIP seq , transcription rate SLAM seq , mathematical modeling , and RNAPII interactome Quantitative MassSpec . That gave us novel insights into function od SPT6 in transcriptional regulation . My working group : Dr. Elmar Wolf : https : www.biozentrum.uni wuerzburg.de molbio research groups ag wolf My other supervisors Prof. Matthias Geyer : http : www.geyer lab.com matthias geyer group leader Prof. Hermann Schindelin : https : www.uni wuerzburg.de rvz forschung forschungsgruppen ag schindelin . I am currently pursuing my PhD at Elmar Wolf 's lab in University of Wuerzburg , Germany . I am interested in understanding the basic RNAPII transcription machinery . We want to understand the role of MYC interacting elongation factors like SPT5 and SPT6 . As transcription is a highly dynamic process , we use acute depletion of protein within 4 6 hours , for studying their direct function . Recently , using AID system for acutely depleting SPT6 , we were able to kinetically differentiate the role SPT6 in RNAPII transcription . Further , I also work on interface of target validation using PROTACs and also , exploring novel transcription factors by screening methods . The key techniques that I use are molecular cloning , CRISPR knockin , targeted protein degradation , basic biochemistry methods , ChIP sequencing , Mass Spectrometry , 4sU sequencing , SLAM seq and basic NGS analysis . I have a keen interest in taking inspiration from nature for everyday solution , or better defined as Biomimicry . Further , apart from quality scientific research , I am keen towards communicating my scientific findings to the general public .. Technologies :",molecular glues;developing;screening;interaction
"Machine Learning Researcher . . Specialities : Machine learning , computational biology , computer vision , human computer interaction , gesture and pattern recognition .. Technologies :",
"Senior Staff Scientist . . Experienced pharmaceutical scientist with broad experience in academic and industry settings . Authored 15 publications including as a corresponding author , 2 patent applications and multiple abstracts at international conferences . Currently managing a team responsible for potency bioassay development as well as for potency and effector function support of preclinical and clinical stage programs . Contributing with technical writing and co authoring of internal reports , regulatory fillings reports post IND and BLA as well as support towards responses to health authority questions . . Technologies : Xray",
"Clinical Bioinformatics Scientist . . Computational biologist with a broad skill set , a successful track record in bioinformatics and data analysis and over five years of management experience . Self motivated , innovative , quick learning with outstanding communication skills . Excellent ability to collaborate with diverse teams and professionals to develop scientific understanding . Broad experience in next generation sequence data and drug discovery with six years of industry experience . Strong background in molecular biology , chemistry , biochemistry , biophysics and structural biology . Able to see the big pictures with simultaneous strong attention to details . SPECIALTIES : Perl , Python , shell script , Oracle SQL HQL , R , and grid computing . Algorithm and tools development , statistics , computational tools evaluation , data integration , analysis and visualization , data mining and text mining . RNAseq , transcriptomics , proteomics , metagenomics , microbiome , comparative genomics , genomic variant discovery and interpretation , genome sequencing , sequence alignment and genome assembly , genome annotation , database creation curation and maintenance , pathway analysis and interpretation , microarray and gene expression analysis . Team management and project management . PUBLICATION LIST : https : publons.com researcher 3238342 qiandong zeng . Technologies :",
"Product Informatics Expert . 3rd rotation Manufacturing Science and Technology Data Analytics Supports the development of analytic capabilities in Vaccines manufacturing for data driven decision making Developing a machine learning model that identifies points for optimization in the fermentation process . Configuring an algorithm to provide real time recommendations for yield improvement . . Career Objective : to enable the utilization of big data and data driven decision making in the healthcare industry Computational Tools : Matlab , R , Python , SQL , Git , Spotfire Skills and Experience : project and stakeholder management , management of matrixed teams , development and deployment of pharmacodynamic models , user acceptance testing , problem solving , agile development . Technologies :",
"Chief Scientific Officer . Leading research across a portfolio of project to identify and develop a range of next generation protein degradation projects . Amphista is advancing a range of completely novel targeted protein degradation TPD mechanisms which address known limitations of current TPD approaches through : i identifying degraders with improved drug like properties , ii broadening the target and cell type scope of degradation and iii reducing resistance potential for degraders used in oncology applications . Discovering new medicines is difficult , I 've spent 20 years doing it so can attest to that . Today though , there are more options , more technologies , more ideas than ever before for helping patients in new ways . There are many unknowns but one thing is certain if we do n't embrace the new ideas and try a few of them , we 're unlikely to succeed building businesses and new therapies using existing dogma . As one of the pioneers of the wave of protein degradation PROTAC therapies now taking the industry by storm , I 'm always interested in learning about new ways to solve old problems and turning ideas into great medicines .. Technologies :",molecular glues;interaction
"Associate Director , Computational Biology . . Experienced scientist with a demonstrated history of working in the pharmaceutical and biotech industry . Skilled in Bioinformatics and Data Analysis . Strong research professional with a Doctor of Philosophy Ph.D. focused in Genetics Minor in Statistics from Pennsylvania State University . . Technologies :",
"Applied Bioinformatics Scientist . Enriched the full length gene consensus repertoire by over 10 folds using a self designed computational algorithm that addresses high error rates in nanopore reads for transgene insertion assay Developed methods that correctly classified 99 of Multiplexed Array Sequencing MAS Seq reads as unusable due to incorrectly sequenced cell barcodes from Deep Mutational Scanning data Achieved a 20 fold increase in off target regions using full length PacBio reads instead of short Illumina reads in AAV gene delivery system Conducted analysis of single cell data from various modalities to better understand the epigenetics of pancreatic neuroendocrine tumors Tested and deployed a novel statistical method to detect mutations from tag based single cell RNA Seq data Incorporated a compendium of computational approaches to predict short repeat regions in the human genome of ALS patients using short read data Interviewed more than 5 candidates for several mid senior to senior roles . Efficient self driven graduate research assistant with success in independent and collaborative research environments . Proven public speaking skills and experienced in presenting at conferences . Highly skilled in conducting research , compiling comprehensive literature reviews and publishing . Passionate bioinformatician with experience in a wide variety of next generation sequencing datasets . Detail oriented and committed to advancing understanding of genomics . Specialities : NGS data processing , Machine learning , Deep learning , Biological databases , Statistical analysis Technologies : Python , R , Java , C , C . Technologies :",
"Co Founder Managing Director at Heisenware GmbH . . Experienced Senior Software Engineer with a demonstrated history of working in the research industry . Skilled in Research and Development R D , I IoT Architecture , Fullstack Software Development embedded to cloud , Node.js , Python and modern C with a Dr. rer . nat . focused in 3D Cryo Electron Microscopy from Max Planck Institute for Biophysical Chemistry . Author of the open source software VRPC https : vrpc.io .. Technologies : CryoEM",
"Bioinformatics Scientist III . . There is something about the job I do , is it dopamine rush from solving challenging problems , is it the constant nagging my brain about a problem until a solution clicks , is it the joy of coding to shape an idea into a reality , or is it the ultimate satisfaction of knowing about the work I do might eventually help people out and make their lives healthier . Perhaps , It is the cocktail of above all that keep me motivated and keep me loving my job of Bioinformatician . I have recently moved to Los Angeles , California I have a work permit after working as a Senior Research Scientist and a Global Scientific Consultant in the Bioinformatics team of the R D department at Eone Diagnomics Genome Center EDGC , South Korea . I have been a proud member of EDGC , seeing it grow from being a small start up company to go public , and it gives me immense satisfaction about the part I played in its growth . My job profile at EDGC involved developing pipelines WGS , WES , targeted panels , liquid biopsy , epigenetics related , data analysis , development of algorithms tools , maintenance of the code , documentation , article writing , and guidance to newcomers . I want to emphasize some of the major highlights of my work experiences so far in my carrier . A recent project at EDGC was to develop cancer detection panels of various cancer types using machine learning algorithms on the NGS based epigenetic data . I designed and developed the NGS based epigenetic data analysis pipeline , statistical modeling to identify the cancer specific markers , and implemented machine learning algorithms to identify cancer patient samples . I was involved in developing custom targeted panels for the liquid biopsy based cancer screening and monitoring service . I designed and developed a patient specific DNA markers selection algorithm , primer identification algorithm for the target markers , and pipeline to analyze patient specific custom targeted panel data . I have experience developing NGS analysis related in house tools such as sequence data preprocessing , PCR duplicate removal and error correction , in house variant caller , variant annotator , SNV classifier , etc . Experience with proteomics , molecular dynamics , in silico drug discovery , and scientific writing from my Ph.D. work . Comfortable with Remote Work culture as I remote worked as a global scientific consultant for three months . Now I am actively looking to pour my experience into something meaningful and challenging in Bioinformatics while getting opportunities to learn something new . Let s get connected if our interests align .. Technologies :",
"Postdoctoral Research Fellow . AFM T l thon Fellowship Application Number : 23210 . Experienced researcher in protein structure analysis and determination . PhD and postdoctoral experience in S o Paulo State University UNESP , Brazil and ENS Paris Saclay France developing experimental structural studies using high performance liquid chromatography , protein crystallography , SAXS , circular dichroism , fluorescence spectroscopy and computational approaches using normal modes and molecular dynamics simulations . I also has teaching experience , working as a professor in high school , technical schools and higher education Sao Paulo State University UNESP Brazil in the disciplines of Biophysics , Radiobiology and Molecular Biology . Currently , I am a postdoctoral researcher at Sorbonne Universit performing the structural characterization of a Kir potassium channel using cryo EM and single particle analysis . . Technologies : Xray;CryoEM;CD",membrane proteins;proteins;characterization;structure
"Principal Scientist Lead Discovery . . Biochemist motivated to provide high quality protein reagents , structural and biophysical data to advance drug discovery efforts . Core skills : parallel protein engineering and production , X ray crystallography , cryo EM , biophysical methods structure based analysis . Principal Scientist , Roche , Switzerland 2022 current Senior Scientist , Roche , Switzerland 2019 2022 Postdoctoral Scientist , Genentech , USA 2016 2019 Ph.D. Structural Biology , The University of Queensland , Australia 2012 2015 Research Associate , BioMarin Pharmaceuticals , USA 2011 M.Sc . Eng . Biotechnology , Polytech Marseille , France 2008 2011 M.Sc . Structural Biology , Aix Marseille University , France 2010 2011 . Technologies : Xray;CryoEM",proteins;small molecules;interaction;screening;structure
"Chief Pharmacologist VP of Non Clinical Development . . As of 1st January 2019 , I am employed by Galimedix as Chief Pharmacologist VP of Non Clinical Development . My last position at Merz Pharmaceuticals was Principle Scientific Expert Pharmacology in the division R D CNS . At the peak of my managerial responsibilities at Merz I was directly responsible for the department in vitro pharmacology . This group consisted of four full time academic employees and five full time technical assistants . In addition , I directly supervised eight doctoral these s and several postdoctoral academics sandwich students . Techniques mastered used included electrophysiology , molecular biology , biochemistry , protein protein interactions and phenotypic screening . My personal hands on methodological expertise is largely focused on electrophysiological techniques such as whole cell and single channel patch clamp , two electrode voltage clamp , fEPSPs LTP and in vivo single unit recordings . My core academic competence is in the neuropharmacology neurophysiology of ligand gated ion channels and GPCRs with a strong focus on the glutamatergic system , as well as protein protein interactions with a strong focus on ABeta . . Biggest successes include elucidating the unique mechanism of action of memantine 37 papers that aided the registration of this compound for the treatment of Alzheimer s disease and the discovery of novel compounds such as neramexane 10 papers . Specialties : Electrophysiology , phenotypic screeing , repurposing , neuropharmacology , ion channels , GPCRs , protein protein interactions and adipose tissue pharmacology . I have published 92 orginal papers , 23 reviews , 214 conference abstracts , 28 patents . I am an editor reviewer for academic journals and fluent in German . Technologies : SLS DLS;SPR;NMR;FRET",membrane proteins;proteins;interaction
Head of Cryo EM Lab . . . Technologies : CryoEM,structure
"Scientist Biophysics . . Research interests include Biophysics , iPS , Organ on a chip , microfluidics , biosensors , protein therapies , drug design , FBLD molecular modeling . . Technologies :",
"R D Scientist . . Working within R D of clinical flow cytometry to help bring new and exiting products to marked Versatile clinical researcher with practical product development experience within the fields of optical biophysics , exotic fluorescence molecules , bioconjugation , antibodies , nanomedicine , flow cytometry , microscopy , artificial intelligence AI and more . . Technologies :",
"PHD Student . Birol Lab Single Molecule Biophysics probing Quantitative Neuroscience https : www.mdc berlin.de birol PhD project decipher initial molecular events and underlying mechanisms that drive alpha synuclein pathology and its contribution to early onset of neurodegenerative diseases utilising state of the art single molecule techniques correlative super resolution light and Cryo electron microscopy studying biophysical properties and dynamics of interactions between alpha synuclein and neuronal organellar membrane systems elucidating the role dys functional alpha synuclein membrane interactions have in inclusion body formation , hallmark of synucleinopathies like Parkinson 's Disease . . Technologies :",idps;interaction;structure
"Scientist . . Highly motivated biochemist biophysicist with 12 years of research experience across a broad range of fields , with strong skills in leadership and multidisciplinary collaboration . I have worked in fast paced environments with very high standards for research quality , and with emphasis on creative problem solving . Research experience includes antibody engineering , protein RNA biochemistry , structural biology , biophysics , immunology and neuroscience .. Technologies :",antibodies;nucleic acids;proteins;engineering;interaction
"Scientist . Department of In Vitro Biology Member of the In Vitro Biology Assay Development lab focusing on the development and validation of a wide array of in vitro assay protocols for a diverse client base that includes pharmaceutical and biotechnology companies . . Highly skilled research biologist with broad based drug discovery knowledge coupled with a strong desire to continue developing scientific capabilities . Major strengths include assay development , molecular biology and protein production . Additional experience encompasses immunobiology , biochemistry , enzyme kinetics and small rodent handling dosing . Proven ability to deliver products by maintaining focus on project requirements , timelines and priorities . Graduate of Wyatt s Light Scattering University LSU Training for Dynamic Light Scattering DLS systems in Santa Barbara , CA . POST GRADUATE COURSE WORK Advances in Molecular Biology University of Delaware Advanced Immunobiology Fairleigh Dickinson University Human Physiology I II Fairleigh Dickinson University Immunology Seton Hall University Biostatistics Seton Hall University . Technologies : SLS DLS",biologics;proteins;expression;screening
"Scientist Computational Biologist . Design , develop , implement , and optimize computational core capabilities to illuminate the dark matter in plants . Lead , perform , analyze , and visualize discoveries for partnership progras . Computational biologist , statistical and probabilistic programmer , and software engineer who infers maximally accurate and precise probabilistic models to understand complex systems in biology . Passionate about developing and implementing technologies that lead to a healthier and more environmentally sustainable world .. Technologies :",
Senior Scientist . . . Technologies :,
PhD Candidate . PhD candidate at the institute of Biochemistry at Free University Berlin . Group of Prof. Dr. Markus Wahl and Dr. Bernhard Loll . Topic : Catalytic Understanding of Bioactive Enzymes . . PhD candidate of biochemistry at FU Berlin . Doing research at the institute of structural biochemistry . Highly interested in structural and functional biochemistry of biocatalytic enzymes . Cryo EM X ray . Technologies : Xray;CryoEM,enzymes;characterization;structure
"Research Associate . Master 's thesis : PROTAC Synthesis , Cancer Drug Development Group . . Technologies :",molecular glues;developing
"Senior Scientist . . I have worked professionally with protein purification and characterization since 1995 , and within the same area during my student years up to a Ph . D. 1993 focused on membrane proteins . During my years 1993 2000 at Pharmacia later Pharmacia Upjohn my focus was on purification and characterization of target proteins for pharmaceutical small molecules research and development Drug Discovery . Included was also activity assay development and structural studies . At Amersham Pharmacia GE Healthcare in Uppsala 2000 now I have been involved in several research and product development projects in the area of chromatographic protein purification and electrophoresis .. Technologies :",
"Principal Scientist . Medicinal chemistry for oncology and immuno oncology programs . . Medicinal chemist with expertise from hit to lead through lead optimization in multiple therapeutic areas oncology , neuroscience , and virology . Experienced in small molecule discovery as well as alternate modalities including antibody drug conjugates .. Technologies :",antibodies;small molecules
Graduate Research Assistant . Characterization and Design of Next Generation Battery Materials Yi Cui Group Developed novel electrochemical tools for characterizing Gibbs free energy and entropy of solvation in lithium battery electrolytes Developed a method to grow graphene on silicon anodes through thermal surface modification and characterized the SEI on graphene coating using cryo EM . . Technologies : CryoEM,
Internal Science Portfolio Communications . . . Technologies : CryoEM,
"Fluid Biomarkers Specialist , Biobank Manager . Experimental Medicine . . . Fluid biomarker specialist in neurodegenerative diseases and CNS related disorders : I have work with fluid biomarkers for clinical trials , pre clinical research and translational medicine as well as with fluid biomarker discovery as diagnostic tool for neurodegenerative diseases . I have experience with analytical method development , context of use conceptualization for method development and collaboration with contract research organizations CROs . I have also experience with PK and ADA assays as well as GLP for biologics antibody and protein drugs . As Biobank Manager , I have gained experience with biobanking from international trials , writing of laboratory manuals and applications for ethical committees VEK .. Technologies :",
"Senior Principal Scientific Researcher . . Biological Electron Microscopy and Ultrastructural Pathology Applications : Characterization of Amyloid Fibrils Tau , Synuclein , Amyloid b Characterization and Identification of Pathogenic Viruses Influenza Virus , SARS Coronavirus , La Crosse Encephalitis Virus , Poliovirus , Varicella Zoster Virus and Herpes Simplex Virus Characterization of Nanoparticles Ultrastructural Pathology for Safety Assessment Various Tissues Correlated Fluorescence and Immunogold Localization of Drug Targets in Cells and Tissues Correlated Fluorescence and Immunogold Localization of Therapeutic Molecules in Cells and Tissues Methods and Techniques : Correlative Light and Electron Microscopy CLEM Freeze Substitution Processing of Cells and Tissues for CLEM Immunogold EM Tokuyasu Method Cryo Immunogold EM Biological Scanning Electron Microscopy Serial Section Array Scanning EM 3D EM Negative Staining EM Ultrastructural Interpretation 3D Reconstruction and Modeling . Technologies :",idps;proteins;structure
"Development scientist . I primarily work on developing and upscaling downstream processes for proteins and peptides . Secondly I use python to automate my data analysis and develop new methods for optimising protein stability and purification . . As A PhD I have independently managed scientific projects , established international collaborations and performed state of the art research . I love learning new techniques and am driven by my desire for knowledge , which is why I prefer to engage in challenging projects . I have chosen to specialize in biochemical biophysical characterization of proteins , due to my inherent interest in this topic and have during my PhD worked on characterizing the structural features determining substrate specificity in microsomal cytochromes P450 . I have also been given the opportunity to perform a variety of teaching activities as well as outreach . Academic research has taught me how to : independently drive a project from initial idea to completion , engage both practical and theoretical problems using an analytical approach and to form successful collaborations . I now wish to apply my skills in a position where the outcome is more readily observable . . Technologies :",peptides;proteins;characterization
"Associate Scientist . Working in selections technology . Speciality Yeast display . yeast staining , FACS , selection , binding assays . 6 years experience in biotechnology and Protein Biology . Technologies :",proteins;interaction
"Postdoctoral Researcher . . Molecular and structural biologist specialized in membrane proteins and generating high affinity binders with a background in physical chemistry , chemical engineering , biophysics , biochemistry and protein engineering . Involved in multiple research projects in collaboration with both academic and industrial partners . Skilled in project conceptualization and design , construct design , protein expression and purification , protein protein and protein drug interaction analysis , as well as functional and structural analysis of membrane proteins . Comprehensive technical , engineering and laboratory skills .. Technologies :",membrane proteins;proteins;small molecules;engineering;expression;interaction;structure
"Bioinformatician . . Skilled developer with over 14 years experience in both academic and commercial environments Fluent in several programming languages incl . Python , Bash , Java , statistics programs e.g. R and scientific libraries incl . BioPython , ggplot2 Familiar with the most commonly used computational environments OS , virtualisation including computation on high performance clusters Proven ability to adopt new technologies and solve complex problems analytically Successful communicator and teacher able to plan and execute workshops , lectures and scientific presentations to both specific and broad audiences . Technologies :",
Postdoctoral Associate . Patapoutian and Ward Labs Research field : Structural basis of mechanosensation . Biochemist and structural biologist with 10 years of experience studying challenging membrane protein targets .. Technologies :,membrane proteins;structure
"Reader in Software Engineering . . University Senior Lecturer in Software Engineering . Always on the lookout for interesting collaborations , especially with IT industry . Research interests : software engineering , model driven engineering , non functional properties , model optimisation , component based software engineering . Technologies :",
"Head Of Image based Screening Systems . Scientist at Lead Discovery Wuppertal . Leading a cell biological lab up to 3 TA with a focus on target ID , lead discovery and lead optimization , thereby supporting small molecule projects along the early drug discovery value chain . Lead the lead discovery activities on an ion channel project that lead to the achievement of a major pre clinical decision point for further lead optimization . Secured a highly competitive funding scheme for a cross divisional Bayer project for 2 years to explore advanced analytic approaches Machine Learning for analysis of high throughput screening data sets . Co leading the pharma part of project since Q4 2019 , which compromises a diverse team of data scientists , biologists and different business functions across 6 different sites . Responsible for communication with external partners , internal stakeholders and the upper management . Co responsible for the setup of imaging based technologies at Lead Discovery in Wuppertal with a focus on phenotyping through High Content Screening with a strong focus on collaboration with our digital functions . Strong collaborative approach as highlighted by the involvement in multiple collaborations , ranging from small start ups to larger alliances . Further , leveraging internal collaborations for setting up novel workstreams to explore novel targets or disease mechanisms , leading to multiple target proposals . Co leading a cross divisional life science community Crop Science , Pharma , Consumer Health with a focus on Advanced Microscopy Methods to explore novel techniques and network with external partners . Applying a broad method toolbox in research , including cell line development clonal isolation , genetic perturbations siRNA and CRISPR , different readout paradigms fluorescence , luminescence , imaging . Generation of big data sets for advanced analysis using custom written analysis routines in collaboration with data scientists . . Dedicated and interdisciplinary trained scientist with 4 year experience in preclinical R D at Bayer Pharma leading the novel department Image based Screening Systems at Lead Identification and Characterization since 2022 . In depth knowledge of applying an analytical mindset to drive forward preclinical small molecule drug discovery programs and expert knowledge in the areas of microscopy including High Content Screening and live cellular assay systems . Strong background in in vitro assays , novel technology and target exploration as well as disease mechanism understanding . Recognized leader as well as strong entrepreneurial and innovation mindset as demonstrated through acquisition of internal competitive research funding leading cross divisional cross functional groups . Strong communicator allowing efficient interactions with employees , management as well as internal and external collaboration partners CROs , academic , biotech .. Technologies :",
"Full Professor . The goal of the Fernandez Busnadiego lab is to unravel the structural basis of fundamental cellular mechanisms , as well as their alterations in human disease . To that end , we employ multidisciplinary approaches pivoting on state of the art cryo electron tomography see e.g. B uerlein et al . , Cell 2017 ; Guo et al . , Cell 2018 ; Collado et al . , bioRxiv 2019 . . Protein aggregates are often found in neuronal cells of patients suffering from neurodegenerative diseases such as Alzheimer 's or Parkinson 's . However , little is known about the morphological characteristics of these aggregates in their native environment . Our group seeks to understand the detailed structure and cellular interactions of protein aggregates within optimally preserved cells to gain insights into their mechanisms of toxicity . To that end we employ cryo electron tomography , a technique that allows 3D visualization of the cell interior at molecular resolution . More information at : http : www.biochem.mpg.de 4857860 06 neuro disease . Technologies : CryoEM",idps;interaction;structure
"Senior Scientist . I work as a computational chemist with a focus on structure based approaches , supporting several drug design projects covering different therapeutic areas and modalities . . Computational chemist with a focus on structure based approaches . I 'm gaining industry experience in supporting drug design projects covering different therapeutic areas and modalities , spanning from early target assessment up to LI LO . I apply molecular modelling , core hopping , library enumeration , molecular dynamics , FEP calculations , machine learning , quantum mechanics , and QM ML methods , among others , where appropriate . I am a co author of several patents arising from my industry work . During my postdoc , I was awarded a Marie Curie Fellowship to carry out research in targeted protein degradation , and as a team , we presented the first X ray crystal structure of a PROTAC in ternary complex with an E3 ligase and a target protein .. Technologies : Xray",
"Postdoctoral Research Scientist . Structure function relationships for integral membrane proteins . . Most modern diseases are due to the deregulation of proteins function . To design inhibitors or drugs , it is crucial to gets detailed information on the folding structure , dynamics , and macromolecular interactions of interest proteins . Using the solution and solid state Nuclear Magnetic Resonance spectroscopy and a variety of complementary biophysical methods ITC , SPR , X ray , CD , I characterized various challenging proteins such as NDM 1 metalloprotein , CK MM more than 60kDa , Alpha Synuclein IDPs , TSPO membrane protein and Adhesin P1 fibrilar protein . These proteins are interesting therapeutic targets because involved in pathway regulation e.g. lysosomal pathway degradation , or in diseases e.g. dental caries formation , cancer , antibiotic resistance . My biochemistry skills allowed me to control each stage of the study : from DNA plasmid to functional studies , through protein production . . Technologies : Xray;ITC;SPR;NMR",membrane proteins;small molecules;characterization;interaction;structure
"Senior Scientist , Computational Biology . . OBJECTIVE : In active search for a challenging opportunity in data analysis , data science , computational biology , bioinformatics , algorithm development , microfluidics , biotech areas . Research and development professional with expertise in designing data analysis algorithms , creating software prototypes , modeling complex systems . Multiindustry expertise including DNA mapping , synthetic biology , PCR based multiplexed assays , microfluidics . Proven ability to solve complex problems , to make sense of convoluted data . Expertise in statistical methods , strong knowledge of applied math . Exceptional analytical skills . Excellent self starter with high adaptability . Knowledge of machine learning , Bayesian analysis and other data analysis approaches . Specialties : Modeling of complex systems , Algorithm development , Data analysis , Machine learning , Bayesian analysis , Bioinformatics , Computational biology , Applied mathematics . Technologies :",
"PHD Fellow . Drug discovery , Cryo EM , TEM , structural biology , biochemistry , Molecular biology Cell work , Immunoassays , mouse models , CRISPR , . Jeg er en h rdt arbejdende , motiveret og organiseret person , med gode brede , tv rfaglige kompetencer indenfor natur og sundhedsvidenskab . Mit prim re vidensomr de ligger indenfor molekyl rbiologi , sygdomme p molekyl rt plan , proteomics , genetik og cellebiologi og jeg har praktisk erfaring fra den biomedicinske forskning . Jeg trives i et udfordrende milj og med komplicerede opgaver , med fokus p kvalitet og faglighed . Jeg nsker et arbejdsmilj fokuseret p effektivitet , men med plads til humor , teamwork og kollegaskab . Desuden har jeg erfaring med undervisning , forskning og en udvidet international forst else . Disse kvalifikationer har jeg opn et igennem mine studier p Aarhus Universitet , som kandidat og bachelorstuderende , studenterunderviser og som udvekslingsstuderende p University of California San Diego samt gennem min praktiske forskning og laboratoriearbejde i et internationalt anerkendt laboratorie i USA , samt Danmark . Yderemere har jeg en baggrund som salgsassistent , hvilket giver mig en forst else for kommunikation , salg og service . N gleord : Cand.scient , molekyl rbiologi , project management , biomedicine , proteomics , genetics , bioteknologi , molekyl r medicin , projektstyring , molecular biology , histology , cell biology , laboratorie . Technologies : CryoEM",proteins;structure
Manager Bioinformatics Data Science . . . Technologies :,
"Senior Research Scientist . PROTAC Toolbox Chemistry Lead Senior Research Scientist SRS with dual responsibilities in the teams of FBLG PROTACs and iLAB within the Discovery Sciences department . Responsible for a company wide automated synthetic chemistry platform build in PROTACs . Professional Committee Membership : Organising member of the Gothenburg Friday Chemistry Seminar Series Dec 2020 present Discovery Sciences Employee Ambassador Nov 2020 present Chemistry Lab Forum Representative Sep 2019 Feb 2022 . Organic and bio organic chemistry researcher Methodical , organised and enthusiastic chemistry researcher with a passion for delivering scientific solutions to challening problems . Skilled chemist with unique combination of organic synthesis , API development and peptide chemistry . Excellent oral communication and presentation skills experience of producing oral and poster presentations at national and international conferences Experience of working in cGMP environments . Experience in the use of automated solid phase peptide synthesiser to produce of library of peptides . In depth experience of analytical techniques : 1D and 2D NMR , LCMS , HPLC normal and reverse phase , XRPD , IR and polarimetry . PC proficient in : Microsoft Office , ChemDraw , Reaxys , SciFinder , electronic laboratory notebooks and various NMR processing software e.g. ACD Labs , MestReNova , Spinworks , WinNMR and Topspin .. Technologies : NMR",molecular glues;peptides;developing
Senior Principal Scientist . . . Technologies :,
"Postdoctoral Researcher . . Postdoctoral Researcher in the Cell Biology department at the University of Texas Southwestern Medical Center . I earned my Ph.D. in Biochemistry and Molecular Biology at Michigan State University , where I studied bacteriophages and giant viruses . My current research focuses on the structural changes that occur during virus host interaction through the use of in situ structural biology techniques , including cryo focused ion beam milling , cryo correlated light and electron microscopy , cryo electron tomography , and subtomogram averaging . I have experience in protein expression and purification , cell culture , virus culture , and standard biochemical and molecular biology techniques . In addition , I have experience writing grants and scientific manuscripts . I am a big proponent of scientific outreach , and during my Ph.D. , I helped establish an ongoing outreach program between MSU and a high school in Lincoln , Nebraska .. Technologies : CryoEM",proteins;expression;structure
Senior Bioinformatics Engineer . . . Technologies :,
"Senior Bioinformatics Scientist . . Computational biology specialist with a broad array of skills . Diverse programming and scripting experience in Perl , Python , C , C , php , R , etc .. Adept in High Performance Computing environments , from advanced usage to cluster design and installation . Database and web development design . Hands on genomic level experimental design and lab experience . Specialties : Programming , Server Architechure , Statistics , Biology . Technologies :",
"Senior Scientist Chemistry . Synthesis of novel drug DNA conjugates for various protein targets using on DNA and off DNA chemical reactions , followed by their purification HPLC and characterization LC MS . Implementation of novel therapeutical approaches in DNA encoded chemical library technology DELT . Optimization of DEL selection process on multiple protein targets . Management of multiple projects in a dynamic and efficient manner . Drug discovery oriented scientist with 7 years of experience in synthetic organic chemistry methods and analytical tools and extensive knowledge of manipulating small , large , and conjugated molecules , leading to the successful generation of DNA encoded chemical libraries , membrane mimetic systems , and drug candidates . Technologies :",small molecules;developing
"ISSF research fellow . I was awarded this short fellowship to continue and expand upon the research undertaken during my PhD. My research is mainly concerned with developing novel state of the art neural network architectures for self supervised learning of immune receptor repertoire sequence data , as well as developing HPC based immunoinformatics tools . . I am currently a Wellcome Trust ISSF fellow at the ISMB working on development of novel deep learning approaches , including self supervised learning , knowledge distillation and transfer learning , to be used in immune repertoire research . During my PhD I developed novel deep neural network models , to analyse ultra high throughput sequencing data , for systems understanding of convergence in immunoglobulin repertoires at the population level . My past experiences , at the BSc and MSc levels , are primarily in computational and statistical approaches applied to evolutionary genomics and phylogenetics . I have applied these skills to various microbiology research projects I was involved with over the course of my undergraduate and Master 's degrees . As an evolutionary and systems biologist by training , I am interested in utilising systems approaches for discovering general principles underlying the complexity of biological systems , in particular , by using large omics datasets .. Technologies :",
"Weed Control Chemistry Lead . LifeScience Chemistry . Innovation Data Science . Collaborations . LifeScience Technologies New Modalities . Functional Excellence Chemistry . Specialties : Medicinal LifeScience Chemistry . Protein Degraders Protacs , Molecular Glues . Proteases . GPCRs . Kinases . Fragment Based Drug Discovery , DELT Screens . Parallel Synthesis . Solid Phase Synthesis . Technologies :",membrane proteins;molecular glues;proteins;screening
Senior Research Scientist . Formulation development of peptide and protein drugs . . Technologies :,peptides;proteins;formulation
Head of genomics services . . . Technologies :,
"Postdoctoral Scholar . I have continued my research in the field of group II intron structural biology in the lab of Dr. Navtej Toor . My work has transitioned to cryo Electron Microscopy , which I am using to determine the structures of RNA protein complexes . . . Technologies : CryoEM",nucleic acids;proteins;interaction;structure
"Associate Scientist . Topic : argenx develops novel human antibody medicines to unlock novel complex targets addressing diseases that are underserved by current therapies . Development , optimization and selection for the clinic of the lead Antibodies generates from the ArgenX plateform . Scientific support to the project including the redaction of scientific reports , patent and regular presentation of the project updates to the team and collaborators . Participation to the redaction of scientific publications Science , 2019 and patents . Development and optimization of new bioassay . CROs management and communication to collaborators . . Techniques used : Library construction , phage display , ELISA , MSD , SPR T3000 T200 , BLI Octet Red96 , antibodies production and optimization HIS engineering , germlining , liabilities correction , flow cytometry Fortessa X20 and cellular assays . Others : . Organisation of internal communication events academy . Electronical Labnote Book responsible : Daily support of ELN users , training and optimization of the system . Training and onboarding of new colleagues . Software used : GraphPad , BIA evaluation , Flowing software , FlowJo , Clone Manager , Octet softwares , . Dynamic scientist with more than 8 years of experience in the fields of Immunology and Molecular Biology . Since the obtention of my master 's degree , I first studied the role of the CD27 CD70 signalling pathway before joining Ablynx Sanofi in 2014 , where I was responsible for the Nanobodies screening and selection of the drug candidates . Since 2016 , I have been working at argenx , where I first had the opportunity to generate , characterize lead molecules and select the most promising candidates for the clinic through in vitro and in vivo studies POC , PK and PD studies . Since 2019 I am involved in the technical , scientific support and management of early discovery projects . COMPETENCES . Antibodies engineering : . More than 8 years of experience in the generation , screening and selection of lead human antibodies or VHH against evaluated targets . Broad Technical skills : . From library construction , phage display , screening and characterization SPR , flow cytometry , engineering , stability studies , PK and PD evaluation up to lead nomination . Collaboraors management : . Management and supervision of collaborators and CROs , discussion with KOLs . Trainings : . Training of new comers , team members 6 in total and supervision of student . Reporting : . Writing of scientific publications Persson EK , Science,2019 and Van De Walle I , J Allergy Clin Immunol , 2021 , patent applications and internal reports . TECHNICAL SKILLS . Library construction scFv , Fab and VHH , selection via phage display , production and purification of pre lead molecules in bacteria and mammalian cells Transfection , Purification . PK PD studies , including detection of ADA immunogenicity . Antibody VHH engineering , including pH dependency Histidine engineering , mutagenesis liabilities removal and germlining of pre lead molecules Library approach and CDRs grafting . Establishment and optimization of protein and cell based assays , including ELISA MSD , SPR , BLI , FACS , PK , PD , T cell activation and proliferation assay . Cell culture , PBMC isolation , cells purification . TRANSVERSAL SKILLS . Presentation of project updates and results to the team and external collaborators . Organization and management of the activities with the collaborators Universities , CRO . Redaction of scientific reports , Patents PCT filling and Publications Persson EK , Science,2019 and Van De Walle I , J Allergy Clin Immunol , 2021 . Supervision , training and onboarding of students and junior Research Associates . Organization of internal communication events R D day and academy events . Technologies : BLI;SPR",antibodies;characterization;developing;interaction
Principal Scientist . . I am a highly trained medicinal chemist . Currently I am a Principal Scientist at Halda Therapeutics OpCo . Prior to this position I was a Research Assistant Professor at the Icahn School of Medicine at Mount Sinai ISMMS . I have a Ph.D. in Medicinal Chemistry and have completed several years of postdoctoral training . My primary research goal has been small molecule drug discovery . I have also interned at Mount Sinai Innovation Partners : the technology transfer office for ISMMS and understand the key points required to commercialize a technology . . Technologies :,small molecules
"Director , Computational Biology , Clinical Biomarkers Diagnostics . Support Amgen clinical trials in Oncology , Inflammation and Cardiovascular disease through Precision Medicine Bioinformatics and Computational Biology Lead functional team and support cross functional product development through collaboration , communication , technology development and provision of clinical and translational data insights Support the formulation and execution of biomarker and diagnostic development through fit for purpose computational and statistical analyses Development and custodianship of the precision medicine data platform , serving as the central data system for biomarker and omics data across all Amgen clinical trials Development and application of novel and fit for purpose AI ML methods and predictive analytics in the context of generation of clinical and translational data insights supporting Amgen clinical trials and internal translational analyses Collaborative formulation of standards for biomarker and omics data , cross functional governance models for accessing data associated with Amgen clinical trials Working cross functionally with clinical teams , data management , biostatistics , medical and therapeutic area functions Contributing to external publications , abstracts , communications and discussions with KOLs Leadership , team building and cultivation of positive work culture . . Technologies :",
"Principal Scientist Medicinal Chemisrty . . Chronic and incurable diseases affect approximately 133 million Americans , representing about 40 of the total population of the country . Common diseases like cancer , diabetes , stroke , mental illness etc . are responsible for 1.3 trillion lost economic output annually . Can we fight back to improve the situation Can we strengthen our economy through a healthier and efficient nation I am a synthetic organic chemist . I am passionate about it as it provides me a broad platform and scope to discover drugs for many common and uncommon diseases . Vast application of organic chemistry creates an opportunity to explore interdisciplinary fields and I am excited to explore the unique opportunity organic chemistry gifts me everyday . Interests : Medicinal Chemistry , Process Chemistry , Small Molecule Drug Discovery . Expertise and Technical Skill : Multi step organic synthesis Natural product synthesis Method development Organometallic chemistry Computational chemistry Small molecule purification and characterization NMR spectroscopy LC MS Mass spectrometry FT IR and UV spectroscopy Gas chromatography HPLC Biotage Microwave reactor Schlenk and Glove box Scifinder and Reaxys search . Technologies : NMR",small molecules;developing
"Privatdozent . Privatdozent in structural and molecular biology of gene regulation and signalling , method development in structural biology , X ray crystallography , NMR and cryo EM . Lecturing of structural methods and biochemistry at BSc and MSc level . Researcher and academic lecturer in structural biology and biochemistry Field of special interest : information processing in biomolecular logic circuits Technical portfolio : structural and molecular biology , biochemistry , biomolecular X ray crystallography , cryo electron microscopy , solution and solid state NMR , bioinformatics , chemometrics , biophysics , protein expression and purification methods . Technologies : Xray;CryoEM;NMR",proteins;structure
"Senior Scientist Synthetic Medicinal Chemistry . Delivery of lead compounds small molecules and PROTACs for the treatment of chronic respiratory diseases within the Early Respiratory and Immunology department . Development of synthetic protocols for the generation of pharmacologically relevant scaffolds in drug discovery . . Dedicated chemist with four years of postdoctoral research and two years of industrial experience in synthetic organic chemistry , medicinal chemistry and quantum mechanical calculations . Well prepared to contribute to a high throughput , challenging environment with focus on drug discovery to cure severe diseases , and synthetic method development for medicinal applications . Laboratory experience in stereoselective synthesis of natural compounds , bioactive small molecules and PROTACs . Comprehensive knowledge in drug discovery lead generation and lead optimization , metal , organo and biocatalysis , rational catalyst design , and isotope labelling strategies for mechanistic analyses . Solid foundation of modern laboratory methods and techniques . Expertize in DFT and post Hartree Fock calculations for reaction pathway simulations and physicochemical property calculations of molecules .. Technologies :",molecular glues;developing
. . MPhil candidate in Biochemistry . Passionate and self motivating in learning more knowledge about cryo electron microscopy cryo EM and Cryo ET . Interested in structural biology and relate protein functions to cellular events .. Technologies : CryoEM,proteins;structure
"Computational Biologist . . I m an experimental protein biochemist biophysicist with a growing interest in computational protein prediction design . I have strong expertise in characterizing protein structure and dynamics for drug discovery using a broad range of structural biology tools , including cryogenic electron microscopy cryo EM , liquid state nuclear magnetic resonance NMR , X ray crystallography , molecular dynamics MD simulations , and mass spectrometry MS . I am proficient at determining protein ligand and protein protein interactions using microscale thermophoresis MST , fluorescence polarization FP , and hydrogen deuterium exchange MS . I am also adept at protein characterization tools such as circular dichroism CD and multi angle light scattering MALS . Additionally , I have over 12 years of experience in molecular cloning , protein expression , and protein purification using affinity chromatography , ion exchange chromatography IEC , and size exclusion chromatography SEC . Furthermore , I have experience in bioinformatics , machine learning , UNIX command line , Python , MATLAB , Mathematica , R , and C .. Technologies : Xray;CryoEM;SLS DLS;MST;CD;NMR;FP",proteins;small molecules;characterization;expression;interaction;structure
"Scientist II Structural Biology CryoEM . Responsible for establishing an internal cryoEM facility . Maintain resources , develop and improve high throughput single particle EM workflows . Set up and optimized in house computational resources for efficient data analysis . Staying current with the developments in the field and initialize resource upgrades to achieve higher resolutions and throughput . Work closely with colleagues on training and company relevant structural biology projects . . Structural biologist and microscopist with passion for facility design , throughput optimization , and training . Excited to apply cryo electron microscopy , tomography , microED , and single particle methods to study structure and function of challenging proteins and complexes .. Technologies : CryoEM",proteins;structure
"Head of Bioinformatics and Software . Head of Bioinformatics , Computational Biology , Data Analysis , Software Infrastructure , Database Architecture and Algorithm Development for a single cell sequencing NGS platform . Also assisting the CEO and CSO with scientific strategy and direction . Responsibilities include : 1 . Development and maintenance of on premise and cloud compute infrastructure and resources . Currently using AWS for our backend cloud native infrastructure , leveraging tools such as AWS Batch , RDS , DocumentDB , ECR . Code base is mostly Python and some SQL scripts . Using Jupyter and Plotly Dash for front end . Built REST API layer for server client communication over HTTP . 2 . Bioinformatics data analysis assay QC , genome alignment , structural variant calling and analysis . Currently using bioinformatics tools such as FastQC , BWA , BEDtools , Picard tools , SAMtools , BCFtools , Varscan2 , EBCall , Mutect2 , GATK , UCSC tools . These have all been containerized for modular use . Container deployment , runtime and management is handled by AWS Batch and Docker . Workflow is handled using Jupyter notebooks and Boto3 . Exploratory data analysis using Jupyter notebooks and RStudio . 3 . Research and development on new biological assays for high resolution cancer diagnostics . 4 . Development of data abstraction layer that interfaces with front end and back end resources . Currently using R , Python , SQLAlchemy , PyMongo , Boto3 . 5 . Development of our LIMS database and inventory experiment workflow management . Currently using MySQL as our relational database and MongoDB as our NoSQL database store . 6 . Management of Continuous Integration Continuous Development CI CD environment using Bitbucket Pipelines and CodeBuild , and version control using Bitbucket . 7 . Project management using JIRA Atlassian . 8 . Algorithm development graph based methods for clustering . . Leader and expert in bioinformatics and cloud computing infrastructure for biotech and pharmaceutical companies , particularly those focused on next generation sequencing . I have a hybrid education in Computer Engineering and Molecular Biology , with 15 years of experience in both wet lab and compute technologies . My academic education was at Caltech , UCSD and SDSU . I am currently leading all bioinformatics and cloud infrastructure efforts at Factorial Biotechnologies . On the software infrastructure side , the goal is to build an integrated , cloud based platform for sequencing sample processing , sample tracking , data storage and management , QC , and data analysis . On the bioinformatics side , the goal is to combine existing methods with novel algorithms for sequencing data analysis . I was the 2nd hire at my previous company Encoded Therapeutics , and led all bioinformatics , data and software infrastructure efforts . I established bioinformatics data pipelines , implemented both AWS cloud and on premise compute and data storage environments , designed high throughput sequencing assays , developed a genomics database , set up interactive genomics visualization tools , and performed all data interpretation and analysis for the company . My bioinformatics infrastructure now supports over 100 employees and my analysis work has directly contributed to 300 M in investor funding . I like to work within in a team environment , and enjoy collaborating with laboratory biologists , data scientists , IT specialists , software engineers and business development teams . I also enjoy managing my own small team . I have many high profile biology publications from my time in academic research , and have deep R D knowledge in genomics , molecular biology , bioinformatics and computing .. Technologies :",
"Senior Cell Biologist . . I was working as a postdoc at Max Planck institute of Molecular Physiology in Dortmund in the lab of Prof. Herbert Waldmann , performing high throughput screening of small molecule libraries and the Phenotype characterization of a cell , using cell painting assay , proteomics technology , FACS and cell imaging . I have more than 6 years professional experience in protein purification and culturing different cell lines . . Technologies :",proteins;small molecules;interaction;screening
"Associate Director , Computational Biology . . Specialties : Next Generation Sequencing , RNA seq , ChIP seq , ATAC seq , Epigenetics , Cancer Biology , Immunotherapy , Automation of NGS analysis and Visualization , Machine Learning , Statistics . Programming Languages : R , Shell Scripting , Python , Perl , C C , Java . OS : UNIX , Linux , Windows , MacOS . Technologies :",
"Associate Computational Biologist . Works closely with cell biologists , geneticists , neuroscientists and software engineers on an interdisciplinary research team investigating the genetic bases of neurological and psychiatric diseases . Responsible for processing and organizing sequencing data from experiments and interpretation of results . Develops software applications and data processing workflows , co authors papers , and works collaboratively to understand the biological stories from experiments that yield sequencing data . . Associate Computational Biologist at the Broad Institute of MIT and Harvard . 4 years of experience working with biological data and developing software around it . Passionate about using computers to make connections within and draw conclusions about the natural world . Curious thinker and enthusiastic collaborator .. Technologies :",
"Research Fellow . Dr. George Church 's group Harvard Medical School Wyss Institute for Biologically Inspired Engineering Concentration : Deep learning , Network integration , NGS analysis , database , Statistics , Genomics . Dr. Li Li is a research fellow in the Department of Genetics at Harvard Medical School . She was trained in Computational Biology at the University of Cologne and ETH . Her main research interests are machine learning , network studies , clinical informatics , and next generation sequencing . She conducted research on network analysis on different diseases , machine learning models for protein chemical interactions , and algorithms of SNP prediction . In Harvard , she is working on developing mathematical models to screen candidate genes for gene therapy . Dr. Li is an editor of Health and Medical Informatics , a panel committee member of NIPS , a committee member of Machine Learning in Health Care , and a reviewer of many top journals , including Bioinformatics , BMC genetics , and AMIA . She has also received many high ranked awards , such as Final prize of MIT solve , Best solution of Harvard BD2 K PIC SURE API , and First place of MIT datathon .. Technologies :",
"Scientist Cellular Immunologist Flow Cytometry Specialist . Supervise flow cytometry and antibody labeling labs , train and educate new users on operation of flow cytometry machines and provide technical supervision for all users assay development , panel designs , and data analyses ; collaborate with investigators to facilitate development of novel applications and to upgrade current technologies available at the company ; develop new or more complex flow cytometry based assays to study biologic and small molecule candidates ; evaluate new and emerging technologies ; influence assay selection strategies , and provide oversight in technology development and implementation . . Experience : Immunology and Vaccine Research , Industry Laboratory Management , Product Development , Technology Transfer Expertise : Multi parameter Immunofluorescence Assay , Immunophenotyping , Cell Sorting , Antibody labeling , Protein Synthesis and Purification , Analyses of Immunofluorescence Data FlowJo , Statistical and Graphic Analyses GraphPad Prism , Familiarity with GCLP Compliance , training and writing Standard Operating Procedures SOPs . Technologies :",
"Life Sciences Innovation Management Business Development . BUSINESS INTELLIGENCE . Assess the merit and strategic fit of biologic targeted therapy . Scientific , Medical Commercial rationale . Multidisciplinary evaluation of targeted cancer immuno modulation therapies . Provide strategic basis for R D , partnering acquisition . Objective opinion . Key opinion leader network in Immunotherapy arena . Analyze high financial risk decisions . Key publications . Molenaar M et al . Cell . 1996 Aug 9;86 3 : 391 9 . Molenaar M et al . Mech Dev . 1998 Jul;75 1 2 : 151 4 . Roose J , Molenaar M et al . Nature . 1998 Oct 8;395 6702 : 608 12 . Molenaar M et al . Int J Dev Biol . 1999;43 7 : 675 80 . Molenaar M et al . Mech Dev . 2000 Mar 1;91 1 2 : 311 5 . Molenaar M. Thesis March 2000 . A dual action of XTcf 3 in body axis formation . . WO2005100402 . Anti P selectin antibodies . WO2007000169 Non human mammalian arthritis model featuring human antibodies against citrullinated proteins . . Miranda Molenaar has over 20 years of experience in the Biotech Industry , managing intellectual property assets , providing competitive and business intelligence analyses to enable business negotiations and strategic decisions . Her solid scientific background lies predominantly in immunology , passive and active immuno therapeutics , oncology and autoimmune diseases , which finds basis in a university degree and a high impact PhD thesis in Medical Biology , followed by several key positions in research and development at Crucell and Genmab and numerous consultancy projects in close collaboration with renowned scientists in the fields of expertise . During these years Miranda served as member of strategic management , patent work group , licensing committee , drug development teams , business development teams and acted at numerous occasions at the interface of external and internal experts with management teams . She gained broad experience in the science , product business development for all kinds of innovative biotechnology based platform technologies . Miranda exploits her analytical skills and know how to enable strategic decisions from discovery to late stage development and company investments . Companies that used her expertise include tech transfer offices , small venture funded to mid sized biotech companies , Venture Capitalists , and Patent Law firms in the field of Life Sciences . Miranda is part of an international and interdisciplinary network of key opinion leaders , specialists , and champions active in this field . Specialties : Strong analytical skills . Intellectual Property strategy . Business Development Strategy . ONCOLOGY AUTOIMMUNITY INFLAMMATION . Immunotherapy . Antibody therapy development . Therapeutic vaccine development . Cell therapy development . Organoid technology . Technologies :",
"Manager , Bioinformatics . . . Technologies :",
"Lab Head Medicinal Chemistry Novel Modalities . . Medicinal chemist working on small molecule drugs and novel modalities PROTACs , bifunctional modulators , molecular glues etc . for the treatment of cancer and other diseases .. Technologies :",molecular glues;small molecules;developing
"Assistant Professor . Scientific focus : DNA nanotechnology based tools and devices for applications in biophysics , molecular biology , nanomedicine , material science , and nano photonics ; development of a next generation DNA synthesis technology for oligonucleotides and de novo gene synthesis . . Our research group is developing DNA based tools for single molecule cryo electron microscopy of membrane proteins .. Technologies : CryoEM",membrane proteins;structure
". . Biophysical chemist with a doctorate in nanobiotechnology . Inter disciplinary research experience involving chemistry , material pharmaceutical sciences , biophysics , cell biology , nanomedicine and chemical neuroscience . Worked with four pioneer scientists in their respective fields : Horst Vogel Biophysical Chemistry , David R. Colman Neuroscience , R. Bruce Lennox Nanochemistry Materials Science and Patrick Couvreur Nanomedicine Biopharmaceutical Technology . Teaching skills at grad and undergrad level . Experience in supervising MSc . , and Ph.D. students . Research expertise in : liposomes supported bilayers ; organic synthesis ; bioconjugation ; confocal fluorescence microscopy spectroscopy ; cells ; drug delivery ; immunocytochemistry ; Cryo EM . Currently looking for challenging independent researcher teaching positions .. Technologies : CryoEM",structure
"Cryo EM Applications Specialist . Working with negative stain and cryo electron microscopy mainly single particle analysis in the EM Facility at iNANO , Aarhus University . . . Technologies : CryoEM",structure
"Assistant Scientist . Guidance and expertise for determining appropriate sample conditions for cryo EM sample grid preparation using a novel device integrating cryo EM with native mass spectrometry technology Oversight on the selection , installation , and imaging parameters for an in house resource to screen and analyze cryo EM samples prepared with the novel device Subsequent image analysis to understand effects of varied experimental conditions on protein samples deposited on EM grids after transmission through a mass spectrometer , and when applicable additional single particle analysis cisTEM Training on TEM operation , best practices , and image acquisition using SerialEM ; training guidance for sample preparation for negative stain or with a FEI TFS plunge freezing device . Curious and creative research scientist with ten years of experience working in cryo EM . Extensive work operating FEI TFS transmission electron microscopes using low dose image conditions for single particle analysis or tomography related projects . Experience with multiple grid sample freezing devices and adept at devising new freezing strategies for challenging samples . Significant experience in TEM facility operations oversight , project design implementation . I enjoy working within a team effort that fosters project development and growth but am also comfortable working independently . I am interested opportunities that seek to expand the utility and versatility of this remarkable method .. Technologies : CryoEM",proteins;structure
"Senior Scientist . . Experienced Senior Scientist with a demonstrated history of working in the biotechnology and biopharma industry . Highly skilled in cell therapy development , antibody discovery , protein engineering and structural biology . . Strong research professional with a PhD focused in GPCR biology from Imperial College London . . Enjoys R , python programming and data analytics . . Technologies : NMR",antibodies;engineering;structure
"Principal Scientist . . PhD in organic and peptide chemistry . Substantial experience in protein chemistry , biology , pharmacology , drug development , project management , and patent strategies . More than 12 years experience in biopharmaceutical research . My research focus has primarily been within chemical and enzymatic modification of therapeutic proteins . Design of protein drugs . Development of processes for manufacture of modified proteins , purification and analytical methods . Author co author of 11 scientific publications as well as several patent applications . I have supervised two PhD students and has acted as external examiner at University of Copenhagen at several occasions . Technologies :",biologics;enzymes;proteins;developing
Senior Principal Scientist . My team works within Pfizers Biomedicine design BMD addressing various biotherapeutic project requirements from lead discovery to optimisation . We are based in Dublin Ireland . . Specialties : Antibody optimisation . Protein display and library technologies . Hybridoma production techniques . In vitro and biosensor based assay development .. Technologies :,biologics;engineering
"Bioinformatics Scientist II . . Experienced Bioinformatics Scientist with 3 years of experience in NGS analysis using python , perl and C in cancer genomics in analyzing large genomic datasets , annotating variants and designing pipelines . Over 8 years of experience with RNA and DNA Seq analysis . Single Cell Analysis o Developed custom analysis to identify multiplexed samples with Hashtags and classify the cells as Epithelial or Lymphocytic based on the UMI counts of antibodies . Generating t SNE plots based on the distance matrix for antibody counts for each cell . o Clustering and expression analysis based on mRNA and Antibody derived tags using 10x genomics pipeline and Seurat package . NGS analysis o Both DNA and RNA on high performance cluster for cancer variant detection , copy number variation and fusion transcripts . Includes UMI analysis to confirm variants . Developing synthetic datasets to confirm functionality of pipelines including synthetics fastq and bam files . Good written verbal communication skills and ability to work in a collaborative environment as well as an independent worker . . Technologies :",
"Scientist . . Experience in computer aided drug design strategies , including structure based drug design , Molecular Docking , Molecular simulations , Virtual Screening , Free Energy Perturbation methods , Homology modelling . Ph.D. in X ray crystallography focusing on protein protein and protein DNA complexes . Experience with biochemical and statistical analysis , knowledge of chemical and biochemical databases including PDB , ChEMBL , ZINC database . Knowledge of application systems including DOCK , GLIDE , RDKit , Schr dinger suite . Experience with GPCR purification and biology . Experience with preparation of negative stain grids for Cryo EM . Knowledge in scientific programming Python .. Technologies : Xray;CryoEM",membrane proteins;nucleic acids;proteins;interaction;structure
"Regulatory Submission Manager for COVID products . Authoring and support for CMC regulatory submissions to multiple global markets for the Vaxzevria Vaccine . An academic researcher by training , I have been a process validation lead for Bioreactor based mAb and vaccine programs . A year ago , I have started to support the associated regulatory submissions to multiple global markets . Since more than eight years , I have dedicated my efforts to the late stage development and validation of upstream and downstream processes for the GMP manufacturing of biological therapeutics , applying a Quality by Design approach . For Vaxzevria , I have been leading the validation strategy and tech transfer for two CMOs in a global network of over 25 CMOs . Before , I acted as a project lead and validation lead for several NBE and Biosimilar projects , after having acted as as DSP validation expert SME . I recently started supporting all types of regulatory submissions for COVID vaccine and antibody programs . Within the field of scientific writing , I am experienced in documentation directly or indirectly addressing the health authorities . I have several years of experience as an academic postdoctoral researcher in the field of molecular infection biology . I am also a certified medical writer and science journalist .. Technologies :",
"Postdoctoral Researcher . In The Hanein lab we use Cryo EM single particle and tomography approaches to determine three dimensional structures of macromolecular assemblies in fully hydrated state , close to their native environment , in situ . We combine cryo focused ion beam cryo FIB for the thinning of frozen hydrated biological specimens with cryo electron tomography cryo ET analysis in unperturbed cells . In the lab I am specialised in cryo EM image processing single particle reconstruction and mainly subtomogram averaging . Nowadays , it is the bottleneck of these technologies , a very new field in continuous change with many things to be done and discovered . . I finished my bachelor s degree in Biology at the Complutense University of Madrid in 2014 . Following this , I completed my Master s degree in Microbiology gaining experience in Molecular Biology and Biochemistry while working on biodegradation of oil by higher fungi . During an internship at the Biological Research Center in Madrid , I began working in the field of Nuclear Magnetic Resonance NMR for the first time with molecular recognition and chemical glycobiology . In 2016 , I obtained a place on the Pasteur Paris University International Doctoral Program Marie Sk odowska Curie actions H2020 and joined the group of I aki Guijarro Biological NMR Technological Platform . During my PhD , I worked on the structural and characterization of Functional Amyloids from the fungal pathogen Aspergillus fumigatus . I obtained the PhD degree in December 2019 . After , I joined the The Hanein lab to work on Cryo EM single particle and tomography approaches to determine three dimensional structures of macromolecular assemblies in fully hydrated state , close to their native environment . I am specialised in cryo EM image processing single particle reconstruction and mainly subtomogram averaging which is the bottleneck of these technologies , a very new field in continuous change with many things to be done and discovered . . Technologies : CryoEM;NMR",proteins;structure
"Principal Scientist . Design , architect , and built one stop shop platform integrated informatics solution for drug discovery to access and manipulate internal and external R D data and support scientific decision making Design , architect , and support global Research sample management activities for biology . Provides computational sciences expertise and support for chemistry and biology departments . Play a Technology expert and Architect role . . Specialties : Data Science , Research IS , Software development , Database development , Cheminformatics , Molecular Modeling . Technologies :",
"Postdoctoral Fellow . Studying the role of the Tau protein in Alzheimer 's Disease using a variety of techniques . Gaining expertise in mammalian cell culture , stem cell culture , a primary tissue culture . Cellular imaging in live and fixed cells using fluorescent microscopy on an array of instruments . . PhD. in biochemistry with advanced analytic skills , a strong publication record , and a even stronger work ethic . Skilled in protein and nucleic acid biochemistry , structural biology , bioinformatics , mammalian stem cell culture , fluorescence microscopy , and data science . Experience programming in Matlab , Python , Java , and C .. Technologies :",idps;proteins;characterization
"PHD Student . Group of Christian Loew Structural Biology Unit EMBL Hamburg Cryogenic Electron Microscopy Cryo EM on integral membrane proteins X ray crystallography LCP , vapor diffusion Molecular cloning , expression , and purification of proteins using mammalian cell culture HEK cells Reconstitution of membrane proteins in membrane mimetics nanodiscs , saposin , amphipoles , detergents . . Technologies : Xray;CryoEM",membrane proteins;structure
"Postdoctoral Scientist . . CV : Feb 2022 to date Postdoc , EMBL Heidelberg Nov 2021 PhD in Biochemistry Summa cum laude , Max Planck Institute of Biophysics department of Structural Biology and Goethe Universitaet Frankfurt am Main , Germany . Jul 2015 Master s degree in Cellular and Molecular Biology 110 110 cum laude , University of Cagliari Italy . Jul Nov 2014 visiting scientist , International Institute of Molecular and Cell Biology , department of Structural Biology Warsaw , Poland . Main tasks : purification , characterization and crystallisation of plant and microbial membrane proteins . Nov 2013 Bachelor s degree in Biology 110 110 cum laude , University of Cagliari Italy Jul Sept 2013 visiting scientist , Harvard Medical School Boston , USA , Department of cancer biology . Main tasks : Assessment of the tumour suppressive effect of miRNA libraries for the treatment of human osteosarcoma by lipo and lentiviral transfection . Wet lab skills : Culture of bacterial , yeast , and human cancer cell lines ; Cell viability assays ; Heterologous protein expression in bacteria and human cells heat shock , lipotransfection ; Protein purification and analysis : detergent solubilization , chromatography FPLC , electrophoresis BN and SDS PAGE , in gel activity assays , immunoblotting , immunopurification , acetonic and PEG precipitation ; DNA isolation , quantification , PCR ; Organelle isolation blending , cell disruption , sonication and purification by differential centrifugation and density gradient sucrose , percoll , optiprep ; Pigment extraction and quantification via UV Vis spectrophotometry ; bright field phase contrast microscopy analysis . Advanced technical skills : biological specimen preparation for transmission and scanning electron microscopy negative staining and vitrification ; autonomous operation of cryo Focused Ion Beam Scanning Electron Microscopes e.g. FEI Aquilos ; autonomous operation of 300 kV electron cryo microscopes e.g. FEI Titan Krios and data collection for single particle analysis and tomography ; tomographic data reconstruction and high resolution 3D structure determination . Computer skills : proficient in Macintosh , Windows and Linux based operative systems ; proficient in Linux bash and MATLAB scripting ; basic knowledge of Pyton scripting ; proficient with the Microsoft office package Word , Excel , Powerpoint etc . , LaTeX , and citation tools e.g. Endnote , Mendeley ; intermediate knowledge of 3D graphic analysis and animation softwares e.g. Chimera , Cinema4D . Languages : Italian mother tongue English C level , advanced German A level , basic . Technologies :",proteins;expression;structure
"Research And Development Scientist . . I am interested in variational approximate inference in probabilistic models and probabilistic modelling in general . Please check the link above for what I like to work on . Not a great hashtag warrior , in the best case , I understand 20 of what people post here .. Technologies :",
"Associate Director , Bioinformatics , Oncology . . Computer Scientist , Computational Biologist , and Bioinformatician , with over 10 years of experience in research development and design implementation of algorithms and computational methods towards biological data analysis for the purpose of genetic biomarker identification and discovery . Proven ability and desire to develop computational strategies and efficient software for analysis of large scale , high throughput data , followed by effective communication of findings via scientific publications and conference presentations . Next generation sequencing NGS analysis , single nucleotide polymorphism SNP array analysis . Programming proficiency in Java , C , and C , with experience in Cloud Computing . Familiarity with AWK , Shell , Python , and SQL . Experience with resources : RefSeq , HapMap , COSMIC , 1000 Genomes , dbSNP , and TCGA . Technologies :",
"Senior Research Staff Scientist . I conduct research in the Information and Systems Sciences Laboratory where I am a member of the Center for Human Machine Collaboration and the Center for Autonomy Computing : Principal investigator on a research program related to predicting rotator cuff injury in workers . Task lead on a research program related to analysis of capabilities and development of metrics for neuromorphic computing platforms . Program manager on a research program related to AI techniques for vehicle engine control . Principal investigator on a research program related to developing statistical and machine learning based prognostic tools for worker injury risk assessment . Principal investigator on a DHS program , Continuous Behavior based Authentication for Mobile Devices . Task lead investigating state space observability on dynamic networks for a Government sponsor . Researcher on a program with a corporate sponsor related to autonomous driving . Program manager on a collaborative research program investigating applications using brain inspired neuromorphic hardware . Principal investigator on research programs with related to airline cabin usability and factory floor process simulations . Principal investigator on a research program with a corporate sponsor and the FAA directed at establishing new injury criteria for future seating configurations . Principal investigator on shared research programs related to goal directed neuromuscular control of movement for enhanced human machine interfaces . Developed robotic calibration solutions involving robotic wire insertion . HRL program manager on KRNS MEANING , part of the IARPA KRNS Knowledge Representation of Neural Systems program . Investigated biologically inspired motor control using networks of artificial spiking neurons for the DARPA SyNAPSE program . Contributed to the DARPA Phoenix program related to telepresence and control of space based robotic systems for harvesting satellites in geosynchronous orbit . . I currently work at HRL Laboratories formerly Hughes Research Laboratories in the Information and Systems Sciences Lab . I 've previously worked at Sandia National Laboratories and General Dynamics Electric Boat in a variety of roles from project engineering to research and development . Specialties : Biomechanics , robotics , control theory , and autonomous systems .. Technologies :",
"Postdoctoral Researcher . Finding new ways to destabilize MYCN , which is a main genetic abnormality in Neuroblastoma . MYCN protien which is a main oncogenic modality in neuroblastoma and several other cancers in undruggable . I identified its partners which modify MYCN posttranslationally . My idea is to target MYCN modifications thorugh inhibiting its arginine methylation and thereby repressing its transcriptional activity . In collaboration with GSK I am currently evaluating preclinical effects of argininge methytransferase inhibitors . I am also involved in developing new PROTACs in collaboration with Tocris Biosciences , UK . During my period in Bristol , as a Co PI I procured two grants to study drug resistance in neuroblastoma and evaluating PRMT5 inhibitors in Rhabdomyosarcoma . Whilst at the University of Bristol , I am involved in giving lectures to third year undergraduate students Developmental Genetics Embryonal Cancers . I am also responsible for taking tutorials for first and second year undergraduate students 4 8 hours per year . I have taken tutorials on the Normal and Tumour cells , Cellular and Molecular Pathology , and Disease and Defence units . I assess the presentation skills of the students and give written feedback . I am regularly involved in supervision of research projects of undergraduate , postgraduate taught and PhD students . My AFHEA training helped in designing innovative methods of teaching . For example , I implemented and engaged students with hands on experience right from the start of the project . Also I effectively engage students in their projects by giving small problems and encourage to come up with solutions on their own . . Seeking a academic position particularly in cancer drug discovery where there is a scope of learning and contributing my expertise towards the progress of the projects . My research interests include : identification and validation of novel anticancer targets and mode of action of small molecule inhibitors that target aberrant cancer signalling pathways , harnessing evidence based medicine to treat sub set of tumours that are highly sensitive to specific anticancer drugs and identification of novel biomarkers which could help predict sensitivity resistance to targeted drugs . Motivated to translate basic research into the clinic for better cancer treatment Specialties : Animal tissue culture , cell based assays ELISA , MTT , alamar blue , luciferase promoter activity , galactosidase senescence and Caspase 3 7 assays etc . , clonogenic assays , drug combination studies , SDS PAGE Western blotting , Flow Cytometry Cell cycle , mitotic index pH3 ser10 , TUNEL assay , PgP , MRP , and Cyclin B1 expression , BrdU , BrU staining , CHIP , gene cloning , qRT PCR , DNA microarrays Affymetrix based , RNA interference siRNA , shRNA , immunoprecipitation , protein degradation assays , immunofluorescence , mass spectrometry basics , basic knowledge of data analysis of OMICS data , routine bioinformatics databases tools and statistical analysis . Technologies :",small molecules;interaction
Professor of Computational and Systems Biology . . . Technologies :,
"PHD Fellow . Nicholas M.I. Taylor 's group Determining the structure of Photorhabdus virulence cassettes , extracellular contractile injection systems , with their cargo variability and limits , by using advanced molecular biology techniques and high resolution cryo electron microscopy . Project funded by LaCaixa Foundation Postgraduate Fellowship Abroad 2021 . I am a motivated , curious and hard working junior researcher in Life Sciences . I have fulfilling experience in experimental design and laboratory tasks , being autonomous in overall planning of experiments and critical in data interpretation . I have strong organizational skills that enable me to efficiently coordinate multiple projects and meet deadlines under pressure , without compromising quality of work or safety . I consider myself an energetic person who loves science , research , swimming , climbing , cooking , travelling , dancing , and spending time with my family . A combination of all these aspects , in properly healthy doses , makes me feel the happiest .. Technologies : CryoEM",proteins;structure
"Scientist in Biophysical Characterization . . I am an expert in the biophysical characterisation of proteins . I have experience with co development and marketing of state of the art biophysical instrumentation , user training and support , science communication , as well as collaboration with academia and industry . Colleagues describe me as supportive , patient , structured , reliable and enthusiastic . I am passionate about supporting researchers in the life science sector so they can obtain reliable and trustworthy data .. Technologies :",proteins;characterization
"Chemistry Group Leader . . Medicinal chemist with 40 publications patents . Major contributor to the development of the FDA approved ADC Zynlonta . Experienced in the field of antibody drug conjugates payload design and synthesis . Collaborative team player , mentor and line manager . Lead chemist on AstraZeneca s Tesirine SG3249 discovery and preclinical development program . External collaborations chemistry support and driver . Synthetic campaign outsourcing from bulk intermediates on Kg scale , to highly potent API purification and isolation . Health and safety group representative . Interests in modern oncology chemistry technologies and fields such as PROTACs , DDR , and IO . Speakers at several forums , including World ADC , and Royal Society of Chemistry conferences . Aim to contribute to and drive oncology drug discovery projects .. Technologies :",antibodies;molecular glues;small molecules;developing
Associate Principal Scientist . . . Technologies : SPR;NMR;FP,
"Senior Director , Research Informatics IT . SENIOR DIRECTOR , RESEARCH INFORMATICS IT April 2018 present Principal liaison between drug development teams and research informatics and IT efforts . Ensuring the alignment of global research stakeholders ' expectations with possibilities within research informatics and within the field of computer science as a whole Providing leadership and direction to research informatics and IT teams , managing and collaborating with a staff of scientists , software developers , IT professionals , engineers , and contractors . DIRECTOR , BIOINFORMATICS January 2005 April 2018 Developed integration strategies for the close alignment and expansion of research informatics and IT infrastructures across Kyorin Pharmaceutical s global research sites . Designed and coordinated the implementation , acquisition , and integration of research informatics and IT solutions in support of ActivX s technology platforms , corporate IT infrastructure , and Kyorin s global drug discovery efforts . Developed , implemented , and validated algorithms for the visual and quantitative analysis of highly complex proteomics data . Provided computational biology solutions utilizing various sequence and structural bioinformatics techniques including virtual screening and molecular docking approaches to aid in the design and improvement of drug candidate molecules and proprietary probes . Conducted next generation sequencing NGS and statistical data analysis PROJECT LEADER , BIOINFORMATICS July 2002 January 2005 Designed and developed Laboratory Information Management System LIMS components in multiple programming languages based on multi tier enterprise systems architecture design models . Designed and implemented the full integration of robotic liquid handlers , automation systems , and scientific instruments into a unified data pipeline infrastructure . . Technology leader with a deep understanding of research informatics data and a love for science and tool building . Passionate about enabling scientists to accelerate drug discovery and experienced implementing , supporting , and applying cutting edge software and hardware solutions to solve new data challenges . Conversant in multiple scientific and technological domains , including genomics , biology , chemistry , data science , information technology , software development , and data management . Proven record of leading projects to increase operational efficiency and improve collaboration among scientific and biotechnology teams . Adaptable strategic thinker able to define objectives clearly ; highly motivated to set and achieve challenging goals .. Technologies :",
"Scientist . Responsible for developing downstream recovery and purification for recombinant peptide based antigens to be tested in pre clinical and clinical trials . I have many hours hands on laboratory experience with everything except for fermentation , working on candidates for malaria , pneumonia and turbuculosis in collaboration with multiple international partners . Development of downstream processes for recovery and purification 1 . Recovery of peptides Depth filtration Tangential Flow Filtration removing cell debris , endotoxin etc . 2 . Purification of peptides KTA Ion exchange , affinity and size exclusion chromatography , Tangential Flow Filtration concentration and buffer exchange Supporting upstream fermentation team 1 . E. Coli L. Lactis fermentation 2 . Knowledge sharing and scientific discussions Upscaling of processes and writing protocols In process analysis 1 . Gel electrophoresis techniques SDS PAGE , Western Blot etc . 2 . High performance liquid chromatography e.g. size exclusion 3 . Dynamic light scattering 4 . Absorbance quantification Manufacturing batches for pre clinical and clinical trials Risk Assessments Improving quality systems in compliance with GMP . I work at Statens Serum Institut as bioprocessing scientist in vaccine development . We develop and set up vaccine pilot batch production under GMP conditions for clinical trials and non GMP for preclinical trials . I currently develop downstream processes for purification and filtration of antigens biologics . This includes choosing and setting up chromatography steps , tangential flow filtration , in process controls , stability studies of the antigen , risk assessment of the whole process to e.g. avoid microbiologic , and finally to upscale the process when it 's time to move forward to creating a GMP batch for clinical trials . Points of expertise : Process development Purification of protein strategies to remove impurities e.g. HCP , enzymes , DNA , endotoxin Fermentation E. Coli L. Lactis Stability studies e.g. intermediates with enzymes as factor , or drug substance in formulation buffer Gel electrophoresis e.g. SDS PAGE and Western Blot HPLC e.g. size exclusion GMP Quality systems Risk assesment Tech transfer Upscaling Previously I have worked with formulation and analysis of pharmaceuticals applying e.g. HPLC , DSC and Raman Spectroscopy . The latter I 've applied during a research stay at the University of Otago , New Zealand , where I developed a method for analysis of amorphous drugs and formulations . Additionally , I am a skilled data programmer using MATLAB and Python for both automation of data processing and multivariate analysis .. Technologies : DSC",peptides;characterization;quality;stability
"Sir Henry Wellcome Fellow . At Manchester , my research focus centres on evolution during interbacterial competition . Using modelling and lab based evolution , I am studying how bacteria evolve during attacks by toxin armed competitors . My aim is to characterise the emergence of new resistance mechanisms , and elucidate their impact on competitive microbial communities . . . Technologies :",
"Postdoctoral Fellow . Cryo Electron Microscopy , Structural Biology , Chemical Biology . . Technologies : CryoEM",structure
"Senior Scientist . Danish medium sized pharmaceutical company with strong focus on dermatology and skin disorders such as atopic dermatitis , psoriasis , eczema and rare diseases . DMPK representative in several cross functional project core teams and with close collaboration with especially chemistry design teams , but also toxicology and pharmacology . Daily management of DMPK in vitro and phys chem team 4 6 persons , scientists and technincians with focus on stability studies including metabolite identification microsomes , hepatocytes , whole blood and human keratinocytes , permeability Caco 2 and plasma protein binding , as well as logD and solubility measurements . Responsible for outsourcing of in vitro DDI studies and data interpretation . Involved in general Discovery DMPK Strategy work and responsible for strategies with focus on Beyond Rule of 5 molecules and small peptides . . Skilled and curious DMPK scientist and leader with 15 years experience from Drug Discovery in small biotech to Big pharma . Responsible for in vitro DMPK assays , outsourcing , and day to day management of in vitro and phys chem teams 4 6 persons , as well as hands on experience . Experienced member of cross functional project core teams , and DMPK representative in Med Chem teams in several successful Discovery projects . Result oriented with strong focus on collaboration and problem solving , and with broad experience from DMPK strategy work with focus on small molecules as well as beyond Ro5 modalities such as PROTACs and small peptides . 10 publications in peer review journals or in press . Social foodie and wine lover with a passion of meeting new people . Married with two beautiful kids . . Technologies :",
"Human Genetics Researcher . I use computational approaches PrediXcan and its extensions on large behavioral datasets in order to pinpoint specific genes within the 16p11.2 and 22q11.2 copy number variants that are contributing to behavioral traits . The first article from this study Integration of genetic , transcriptomic , and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes is available on BioRxiv . I have also been involved in outreach through the Science and Education Partnership program , as well as chaired Admissions and Recruitment for graduate students to our department . . I conduct research in human psychiatric genetics in the Lauren Weiss Lab at UC San Francisco . I enjoy applying GWAS and post GWAS approaches to big cohort datasets in order to answer questions about human behavior . Previously , have tried my hand at computer graphics based simulations and RNA seq analysis including single cell . I will be on the job market towards mid 2021 and am looking primarily at non academic careers ; however I am open to discussing opportunities in academia . I am a hard working independent learner who is eager to take on challenges . I enjoy collaborating with others as part of a team , and I find collaboration makes difficult tasks run more smoothly . In addition , I am passionate about teaching , training , and science education for the general public . . Technologies :",
"POSTDOCTORAL RESEARCH FELLOW . . My research includes single particle cryo EM analysis for atomic resolution structure determination of biological molecules , as well as cryo ET of cells and organelles towards subnanometer resolution . . Technologies : CryoEM",proteins;structure
Scientist . . . Technologies :,
"Scientist and Head of PhysChem . . Scientist Lab Head PhysChem with expertise in Solubility , Lipophilicity and Stability matters for several types of Small Molecules , PROTACs and small peptides .. Technologies :",peptides;stability
"Laboratory Technician . Lab Technician Fromme Lab Bioenergy Studying the structural basis of the PSI LHCI Cyt b6f supercomplex utilizing SPA Cryo EM Develop new processing and visualization scripts for X ray Emission Spectroscopy data Analyze Cryo EM data using Relion and VMD MDFF to determine 3D protein structure . I am a Masters student at Arizona State University pursuing a degree in Biomedical Informatics with a certificate in computational life sciences . I work at the Center for Applied Structural Discovery where we focus on determining the structure , molecular dynamics , and the overall system of many crucial proteins responsible for Photosynthesis PSII , PSI , cyt b6f , PC , ATP Synthase , etc . My responsibilities range from protein isolation purification , Cryo EM , and X ray crystallography depending on the protein . I also have experience analyzing EM data , serial crystallography data and X ray emission spectroscopy data collected from various labs around the world . I have experience collecting serial femtosecond crystallography biophysics data from various international accelerator laboratories including the EuXFEL in Germany and SLAC in Stanford , CA . I have also joined a team that is developing a new data processing pipeline for X Ray Emissions Spectroscopy data in hopes to better observe the oxidation state changes in the oxygen evolving complex inside Photosystem II during photoexcitation . On top of my job , I also volunteer at the Center for Personalized Diagnostics where I am developing new data fusion deep learning software to assist in diagnosing developmental dyslexia using multi omics datasets . I am using machine learning in order to better explore data containing genomic , metabolomic , phenotypic , and possibly micro biome data for dyslexic and normal cases . The field of multimodal data fusion and deep learning is still fairly new in regards to systems biology so we are excited to push the boundary and see what comes from it .. Technologies : Xray;CryoEM",proteins;structure
Americas service support . Cryo Electron Microscopes . . Technologies : CryoEM,
"Postdoctoral Associate . . A highly motivated postdoctoral research associate with extensive experience in cryo electron microscopy , including hands on experience in sample grid preparation with Vitrobot and CP3 , independently operating the microscope Titan Krios , Glacios and Talos F200 . Expertise in structure determination software including Relion , cryosparc , EMAN2 and model building software including Chimera , Coot , Rosetta and Phenix .. Technologies : CryoEM",proteins;structure
"Postdoctoral Fellow . Identified the mechanistic link between disrupted folate metabolism and adenine auxotrophy by utilizing genome wide genetic screens and large scale drug screens 90,000 compounds Developed biochemical and cell based assays of folate and purine metabolic pathways Designed experimental pipelines for high throughput phenotypic screening for modulators of subcellular MTHFD1 function Designed and optimized in vitro assays for novel PROTACs in collaboration with an in house chemist . Experienced Postdoctoral Researcher with a demonstrated history of working in the research industry . Skilled in Molecular Biology , High Throughput Drug Screening , Biotechnology , Cell Culture , and Microscopy . Strong research professional with a PhD in Bioengineering from UC Berkeley UCSF . . Technologies :",molecular glues;proteins;small molecules;interaction;screening
Scientist . . . Technologies :,
"Professor in Decision Sciences . . Experienced Academic with a demonstrated history of interdisciplinary research , knowledge transfer , teaching and leadership in higher education . Skilled in Optimisation , Data Science Machine Learning , Operations Research and Applications Contexts including Logistics , Marketing , Healthcare and Computational Biology . Experience of research in a variety of international contexts including Germany , Australia , Belgium , US and UK .. Technologies :",
Clinical Research Data Manager . . . Technologies :,
"Senior Research Associate . Molekyl r biologi . I work primarily with amylases . Protein engineering , Site directed mutagenesis , Bacillus expression . Cloning in Bacillus , Screening of libraries in Bacillus , and amylase activity and stability assay . Technologies :",proteins;engineering;stability
"Senior Scientist . DMPK Developing computational and mathematical PKPD models to determine FIH dose projections and guiding early feasibility analysis . Developing QSAR models for predicting ADMET endpoints using ML and DL techniques . Developing shiny applications for various projects for non experts . In depth knowledge of Mechanistic PK PD model development for large and small molecules , Machine learning techniques , programming in Matlab , R , Python . Experienced in 1 Building optimization algorithms 2 Building mechanistic population PKPD models using Nonmem , Monolix , Matlab , R 3 Analyzing Omics data . 4 Building basic PBPK model using simcyp , PKSim 5 Building shiny apps to communicate PKPD model results 6 Developing QSAR models for predicting ADMET endpoints using ML and DL techniques .. Technologies :",
"Principal Investigator . Advisor : Eva Nogales , PhD . Passionate research scientist uncovering mechanisms of molecular and cellular biology through protein RNA biochemistry and cutting edge structural methods including cryo EM cryo ET . Currently a Principal Investigator at a Stealth Biotech in SF NIH NIGMS K99 R00 awardee Helen Hay Postdoctoral Fellow : UC Berkeley Eva Nogales Lab and MIT Thomas Schwartz Lab PhD : Johns Hopkins University , Biochemistry , Cellular and Molecular Biology Rachel Green Lab .. Technologies : CryoEM",nucleic acids;proteins;structure
"Research Scientist . . Highly ambitious , hard working and solution oriented scientist , possessing a high personal drive to always learn new things and to get better in my line of work . My experience has taught me that I am very motivated when challenged in a environment with big responsibilities and strong commitment During my professional carrier I have had several roles in the field of New Product Development and Introduction NPD NPI , including Quality Assurance , Research Scientist and Project Coordinator . I have through these roles worked in close collaboration with highly skilled colleagues across all departments and functions of the company . I have during these collaborations attained high knowledge and experience with Design Control , Risk Management and New Product Development . I am very solution oriented , and have quickly gained strong communication skills coupled with a great ability to coordinate and execute assignments with different stakeholders , while setting direction and driving high quality work . My personal drive and motivation is at its highest when working on innovative or ground breaking project , where I will be challenged to create valuable and sustainable solutions . I always approach all assignments with curiosity , professionalism and humor , as I believe that an informal yet professional work space is the ideal environment for innovation and motivation . Hard Skills : Process and Method Validation Research and Development Antibody Development and Characterization Proteomics and Probes IHC and ISH Statistical writing Quality Assurance Planning Time Management Process Optimization Risk Management Design Change Control Biotechnology , Biochemistry , Pathology Immunology cGxP Soft Skills : Pragmatic Mindset Good Communication Interpersonal Skills Negotiation Conflict Management Structured Logical Committed Persistent Reliable Responsible Solution Oriented Attention to Detail Ambitious Self motivated IT Skills Microsoft Office : Word , Excel , PowerPoint and Sharepoint ERP : SAP and Oracle . Technologies :",antibodies;characterization
"Technician . Cryo electron microscopy . Biologist skilled in Cryo and Classic Electron Microscopy , sample preparation , data analysis , science , protein purification and expression . PhD focused in structural biology electron microscopy . . Technologies : CryoEM",proteins;expression;structure
"Principal Research Associate . . Biomedical Scientist currently working as Principal Research Associate at Dragonfly Therapeutics . Been 25 years in the pharmaceutical industry , most recent as Principal Technician at LEO pharma and before that as Specialist at Alligator Bioscience in Lund . Main areas are protein characterization HPLC UHPLC , DLS , MALS , CD , ELISA , endotoxin analysis and formulation of proteins . Also some experience of expression and purification of antibodies and compatibility studies for clinical trials .. Technologies : SLS DLS",antibodies;proteins;characterization;formulation;structure
"Research Scientist 2 , strain development . . Scientist with over 10 years of experience in research and development . . I have been working on multiple R D projects in a multinational environment , delivering yeast strains with improved metabolic pathway and titers as well as mammalian cell strains with improved antibodies titers . . Strong experience in synthetic biology , metabolic engineering and biochemistry for the synthesis flavors , fragrances and active pharmaceutical ingredients . Skilled in mammalian cell culture for the production of antibodies . . Technologies :",antibodies;expression
"Principal Investigator Discovery Molecular Biology . . Highly accomplished structural biologist , protein engineer , and molecular biologist with 28 peer reviewed publications . Created multiple expression libraries for mammalian and bacterial expression of viral and human proteins . Completed three small molecule fragment screening by X ray crystallography campaigns against infectious disease targets . Demonstrated experienced in the vector construction , expression and purification of recombinant proteins , as well as structural biology , enzymology , analytics , directed evolution , assay design and development . Headed a fragment hit to lead development project through strong , concise , and consistent written and oral communication . Enthusiastic and inventive with proven outstanding leadership skills . Technologies : Xray",proteins;small molecules;engineering;expression;screening;structure
Cell and Molecular Biologist . . . Technologies :,
"Research Associate , Microbiology . Cultures filamentous fungi from vials of frozen vegetative mycelium on agar plates Streaks new cultures , organizes growing cultures , monitors growth , separates mixed cultures , harvests mycelium once cultures reach maturity , runs genomic DNA extractions . Experienced programmer , handles all lab data manipulation for the Strain Collection team Excel and Python , works closely with software developers on LIMS integration with our biology workflow LifeMine is a drug discovery startup made possible by the recent plummet in the cost of DNA sequencing . We sequence the genomes of a diverse set of fungi , then search their genomes for possible leads for novel medicines . More information about the company , the team , and recent publications are all publicly available at lifeminetx.com . . Research Associate , experienced in many types of molecular biology and microbiology assays . Bachelor 's of Science in Molecular Biology , and a Minor in Mathematics from Binghamton University . Intellectual interests : I love listening to long form podcasts , interviews , audio books , and lectures . Some favorite podcasters authors professors : Tim Ferris , Sam Harris , Rhonda Patrick , Peter Attia , Lex Fridman , Yuval Noah Harari , Bret Weinstein , Sean Carroll , Douglas Hofstadter . Favorite topics : evidenced based health and well being , philosophy of mind , neuroscience , mathematics , machine intelligence , evolutionary biology , ethics , morality , and cutting edge technologies like robotics , synthetic biology , brain computer interface . Hobbies : non dual insight meditation mindfulness , natural language acquisition working hard on Swedish .. Technologies :",
"Lecturer in Bioinformatics . . I was graduated as a medical doctor in Russia in 1992 Pavlov State Medical University , St. Petersburg , Bachelor in Medicine as recognized by UK NARIC . For several years I combined clinical work in emergency medicine and in medical oncology . In 1998 I completed a PhD project that studied sources of oestrogen in breast cancer patients Petrov Institute of Oncology , St. Petersburg , Russia . After PhD , supported by the Royal Society , I went for a postdoctoral fellowship to Edinburgh University , where I studied mechanisms and markers of endocrine resistance in breast cancer . Working with data rich methods qPCR microarrays I became interested in data analysis and fully switched to bioinformatics . After completion of MSc in Bioinformatics Cranfield University , 2012 I worked in the Department of Medical Genetics in the University of Cambridge , where I provided bioinformatics support for a variety of studies in heritable predisposition to cancer . Throughout my research career I published many well cited articles about cancer and bioinformatics see publications at https : scholar.google.com citations hl en user hGLjJ kAAAAJ . In 2021 I returned to Cranfield University in a capacity of a Lecturer in Bioinformatics . Till recently , my career has been heavily biased toward research . However , I also always enjoyed teaching . I supervised MSc and MPhil projects in Cranfield and Cambridge Universities . I run a course about RNA sequencing data analysis in EMBL EBI Hinxton , UK . For several years I contributed to teaching in Edinburgh University as an invited Lecturer . I completed PgCert in Academic Practices ; and I am a Fellow of The Higher Education Academy UK . See http : larionov.co.uk for more detail .. Technologies :",
"Director , Head of Diagnostic Bioinformatics . . I am computational biologist expert in combining experimental data with theoretical methods , analysing large data sets and figuring out relevant patterns in them . Key techniques and skills Computational modelling in bioinformatics e.g. sequence alignment , genomic pipelines , motif search , variant calling and in structural biology e.g. structure refinement , free energy calculations Statistical analysis of large data sets e.g. dimensionality reduction , pattern recognition , tailored approaches to data analysis e.g. time series analysis , rare event sampling Skilled programmer C C , Python , Unix Shell , experienced user of high performance computer resources Excellent teamwork skills collaborating with a wide range of chemists and biologist to tackle challenging research projects see list of peer reviewed publications Proficiency communicating scientific ideas in manuscripts and in oral communications , extensive experience in writing and evaluating scientific research proposals . Technologies :",
"Senior Scientist . Improve efficiency , robustness and compliance of approx . 10 API Active Pharmaceutical Ingredient production routes . Perform trouble shooting on process deviations . Perform process surveillance . . I am a result oriented medicinal chemist PhD with 15 years international experience in pharmaceutical industry and with profound knowledge of the drug discovery process . I have extensive managerial experience , both as project manager and line manager . With my open , empathic and accessible management style I am able to create a positive atmosphere in which people feel free to operate , perform to high standards and are able to develop themselves . I am structured and have eye for detail . With my analytical way of thinking combined with my creativity I am able to generate new ideas based on complex data sets and convert these into working plans or streamlined procedures . I am a team player with a drive to improve processes . Specialties : medicinal chemistry , synthetic organic chemistry , drug discovery , drug design , PET tracer design , nuclear receptors , GPCRs , kinases , endocrinology , fertility , contraception , oncology , immunology , sexual dysfunction , pain , project management , people management , coaching , process improvement , in depth knowledge of Excel , logistics . Technologies :",
"PhD in Neuroscience . I am a PhD researcher in the L land group , at the Department of Neuroscience , University of Copenhagen . I am investigating the structure and function of human Neurotransmitter Sodium Symporters NSSs in complex with CNS targeting drugs via cryo EM cryo electron microscopy and pharmacological radioligand binding competition assays . . pharmacist and PhD student : structural biophysics of neurotransporters in complex with CNS drugs , L land group , University of Copenhagen . Technologies : CryoEM",membrane proteins;interaction;structure
"Advances Workflow Specialist . State of the art Electron microscopy and convencional histology techniques . I started my career in science at Instituto Gulbenkian da Ciencia under the supervision of Prof. Leonor Saude . Due to my ongoing interest in Biology , Anatomy , and Pathology , in 2007 I received my undergraduate degree as a Biomedical Scientist and in a few years , already working as a Histotechnologist at Instituto de Medicina Molecular , I enrolled on master program studying the Histomorphometric and genetic profile in patients with osteoporosis . It was as an Electron Microscopy specialist supervisor in Histology and Comparative Pathology Facility that I have developed strong autonomy and some leadership skills . My responsibilities were coordination of the Department of Electron Microscopy and direct supervision over technical staff . I enrolled in projects that required cryo ultramicrotomy of chemically fixed samples Tokuyasu technique , immuno Gold labelling and CLEM , also rtTEM and negative staining of biological and non biological samples . In a more clinical context , I was involved in the re establishment of the Primary Ciliary Dyskinesia service in Portugal . I recently started to work as a Thoracic Research Associate at the Royal Brompton Hospital , working with the Primary Ciliary Dyskinesia PCD team under the Supervision of Professor Claire Hogg . My role is to help develop as artificial intelligence deep machine learning tool to help in the diagnosis of PCD , to make it quicker , friendlier and hopefully even more reliable . I am also involved in many diverse projects in Portugal and in the UK , that involve high resolution Tomography , cryo EM and negative staining of biological material . I am also involved in COVID 19 related projects . Technologies : CryoEM",
"Senior Principal Scientist . Medicinal Chemistry for the indication NASH . . Current topics of interest : NASH animalhealth oncology immuno oncology , DNA repair , oncogene signalling endocrinology . Activities focus on design of drug like SMOLs , PROTACs , covalent inhibitors , chemical probes design of DNA encoded libraries . Lars is one of the main inventors of BAY 1895344 Elimusertib , Bayer s ATR Inhibitor , which is currently investigated in phase I clinical trials see NCT03188965 . Join my science network on LinkedIn and follow me on Twitter : WortmannLars . Technologies :",molecular glues;developing
"Research Scientist . Group of Surface and Colloid Chemistry , Department of Application Systems Analysis , Division of Protein Chemistry Assays . . I am a Physicist with a PhD degree and 12 years of research and hands on experience within the fields of Experimental Biophysics and Surface and Colloid Chemistry . During these years , I have moved among different disciplines , countries , in academia and industry , and worked with dynamic and international teams . I have also gained experience in project management and Agile ways of working , and thrive with teamwork and communication among colleagues of different backgrounds and disciplines . Currently , I am a Research Scientist at Novozymes , working in the development and implementation of different biophysical , surface and colloid techniques to the mechanistic understanding of enzymes , their interactions with substrates and formulation components , and their application mainly in biological detergents and in food . Before this , I worked as postdoc and assistant professor at the Dep . Pharmacy , University of Copenhagen , when I focused on understanding the structural effects and interactions of antimicrobial peptides , nanoparticles and oxidation on lipid membranes , for which I employed neutron reflectometry , SAXS , QCM D , FTIR ATR , DLS and fluorescence . Previously , I was a postdoc at the University of Southern Denmark Odense , working on the application of micropipette manipulation to characterize different interfacial and colloidal systems , such as liposomes , surfactant and lipid coated interfaces , microparticles and emulsions , as vehicles for peptides and hydrophobic drugs . I have a BSc in Theoretical Physics , a MSc in Biomedical Physics , and a PhD with distinction cum laude from Complutense University Madrid , Spain , with stays at the University of British Columbia Canada and Universitat Jaume I Spain . My research during my PhD studies was around the lipid protein interactions , structural and mechanical effects of the two hydrophobic lung surfactant proteins on lipid membranes , crucial for the design and development of clinical surfactants for lung therapy .. Technologies : SLS DLS",enzymes;characterization;formulation;interaction
"Research Associate II , Autoimmunity Transplantation Inflammation . Generating biochemical profiling data for compound screening Developing and optimizing in vitro enzymatic assays using LC MS as readout Exploring alternative methods antibody based detection , ELISA and FRET based assays , biotin pull down assay , protein degraders Expression of recombinant proteins in mammalian cells Cloning , mutagenesis and design of plasmids Cell culture and cell transfection In vitro translation of proteins Western blot and WES JESS technology , qPCR , HTRF , immunofluorescence , FACS . . Technologies : FRET",molecular glues;small molecules;characterization;expression
"Principal Scientist , Computational Biology . . Experienced data scientist developing computational strategies to interpret Big Data from genomics , illuminating how neurons and immune cells work .. Technologies :",
"Scientist . . Experienced Scientist working in the Biotech Industry . Strong research professional skilled in Protein Chemistry such as Protein Engineering and Design , Protein Interactions , Phage Display , Protein Purification , Protein stability Structure .. Technologies :",proteins;engineering;interaction;stability
"Senior Bioinformatician . . Software developer Bioinformatician with over 15 years experience working in both the Bioinformatics and Genetics domains . I combine extensive experience in software development with an understanding of science of Genetics . Specialties : IT : Java , Perl , Unix scripting , Oracle PL SQL , database design Other : Genetics , sequence similarity search tools , statistics . Technologies :",
"Bioinformatics Scientist II . . I 'm a bioinformatics scientist and software developer that is committed to providing NGS technology for clinical decision making . I have worked on integrating secondary and tertiary sequence analysis software to identify relevant treatments for somatic mutations , and developed bioinformatics components to a somatic pipeline . As a doctoral student , I have collaborated with immunologists and clinicians to develop novel bioinformatics methods to identify key epigenetic markers to quantify immune cell composition from patient blood . In addition to developing sequencing tools for clinical reporting and biomarker discovery , my interest lies in leveraging molecular data for clinical analysis and interpretation . . Technologies :",
"Bioinformatician . . Analytical and proficient bioinformatician with over 8 years of experience in a research environment using a variety of programming languages and techniques . Highly trained to analyze a variety of biological and experimental data sets , with a specific emphasis on large data sets . Experienced in working collaboratively across projects and different institutes .. Technologies :",
"Associate Professor . Research the structure and function of P2X receptors using cryo electron microscopy and X ray crystallography with Dr. Steven Mansoor . Solve structures of membrane proteins using cryo EM and crystallography . Design and test molecules with potential to bind proteins . Build , maintain , supervise , and run the laboratory cell culture facility and cell lines , including insect and mammalian lines . Grow and maintain chemical laboratory and equipment inventories . Serve as laboratory safety officer . Complete protein expression , purification , and characterization in bacterial and cell culture systems , including the use of FPLC , HPLC , SDS PAGE , and other techniques . Plan and construct of new expression vectors . Build and maintain Linux computer systems . Assist with writing and submission of publications and grants . Train , supervise , and mentor new lab members . Serve on the graduate admissions committee . Teach occasional classes . Research Associate , August 2020 October 2021 . I have a passion for working with proteins and drug molecules that matter to human health . My areas of expertise include protein biochemistry , tissue culture , structural biology , crystallography , and single particle cryoEM . Unlike most PhDs that are experts in only one system , I have an expansive understanding of general biochemistry having taught university level biochemistry with laboratory for fifteen years . There is no better way to learn something than to teach it . I love working with my students to create valuable and meaningful learning through experiences in the classroom and the laboratory . In addition to covering core biochemistry topics , I have also taught the biochemistry of cancer , wound healing , HIV , Ebola , chemical warfare not my idea , CRISPR , and now Covid19 , among many other things . I always maintained my involvement in and love for reseach both in my own lab and others . I have worked as a visiting scientist in labs at Yale , Northwestern , and Oregon Health and Science University twice over multiple summers and during my sabbatical , gaining a wealth of experience and learning new techniques in protein chemistry and structural biology . Outside of science , I served as the artistic director for Portland Actors Ensemble Shakespeare in the parks in Portland for six years and led the group to significant audience and financial growth . Publications can be found at NCBI PUBMED : Godsey MH Author . Technologies : Xray;CryoEM",membrane proteins;proteins;small molecules;characterization;interaction;structure
"Consultant Process Scientist . . Consultant Process Scientist at Regeneron , Limerick . . Working for the Manufacturing Support team in the Process Sciences department . . Experience in both upstream and downstream across multiple monoclonal antibody products . Previous experience working in Operations at MSD , Brinny , in the manufacturing of conjugate vaccines . . Technologies :",
"Physicist . . I investigate ultrafast dynamics in atoms and molecules . In strong field physics , I calculate the dynamics of molecules acted upon by laser fields . In biological contexts , I calculate the evolution and decay of quantum information due to interactions with the surrounding environment . The role of quantum mechanics in biological systems touches on fundamental questions regarding quantum information processing in systems experiencing decoherence . In addition to developing new theoretical treatments for photosynthetic molecules and the avian magnetic compass the way migrating birds tell which way is North , I have developed a quantum algorithm which makes use of incoherent , irreversible processes to solve NP complete problems . Specialties : theoretical physics , ultrafast dynamics , time dependent Schroedinger equation , decoherence , quantum physics , strong field physics , quantum information , quantum algorithms , quantum biology . Technologies :",
"Scientist . . I am Scientist at Denali in Structural Biology . I have the ability to drive projects to completion , as shown by numerous first author publications , including in Nature , Nature Structural and Molecular Biology and Nature Communications . I have technical expertise in X ray crystallography , cryo EM , biophysics , and the purification and characterization of difficult protein systems . I have commercial experience through my previous work as a corporate lawyer , and I am admitted to practice in Victoria , Australia .. Technologies : Xray;CryoEM",proteins;characterization;structure
". . Highly organized , motivated researcher , proficient in biochemistry and X ray crystallography of proteins and protein complexes ; currently working with CryoEM of membrane proteins in nanodisks and liposomes .. Technologies : Xray",membrane proteins;proteins;interaction;structure
"Pfizer Summer Growth Experience Informatics for Molecular Pharmaceutics Intern . . Pursuing a Bachelor 's degree in Bioinformatics and Computational Biology and Computer Science at Worcester Polytechnic Institute , expecting to gradate in May 2023 . Seeking an internship position for the upcoming summer 2022 or full time employment opportunities post graduation , with a general interdisciplinary interest in software use and development , lab work and or other practical and professional experience . Other Involvements Include : Residential Advising VOX Musical Theatre Alpha Xi Delta Iota Xi Chapter Technichords A capella Alden Voices Choir . Technologies :",
". . Structure Biology , single particle Cryo EM , DNA repair . Technologies : CryoEM",proteins;structure
"Director of Preclinical Pharmacy . . I have more than 16 years of experience in Translational research in the field of Radiopharmaceuticals for Molecular Imaging and Cancer Therapy in Academia and in Pharmaceutical industry . Authored 64 peer reviewed scientific publications of original research as a PhD student , Post Doc Research Associate and as Senior Research Fellow . As a member of international renowned research groups , I led a number of international collaborations of diverse projects in the field of Radiopharmaceuticals . My research focus is the preclinical characterization of molecularly targeted systems as diagnostics and or therapeutics for translational applications . These systems include small molecules , peptides and proteins . My research efforts have included the development of Radiopharmaceuticals for Peptide Receptor Radiotherapy PRRT , Alpha Targeted Therapy TAT and Theragnostics for cancer therapy and diagnosis , as well as the development of molecular imaging prognostic biomarkers for brain and immune function , infectious diseases , using advanced state of the art small animal imaging platforms . I have gained strong skills in Research project management , knowledge and experience in Radiochemistry , RadioBiology , Radiopharmacology , Analytical Chemistry , GLP GMP QC , Protein Chemistry , In Vitro , Animal studies , Dosimetry and Imaging .. Technologies :",peptides;proteins;small molecules;characterization;developing
"Consulting Statistician . Part of a team designing , implementing and testing novel Bayesian hierarchical models to estimate and forecast population estimates . Implemented time series models regARIMA and State Space Models SSMs to produce international migration estimates . Created a tutorial on SSMs and a user guide to enable other teams to understand and run the models and build on the R code . Work with academic advisors to implement , test and document Age Period Cohort based models to project UK mortality rates in R. Created a user guide to explain the models and their implementation in detail . Improved the R code and added comments to explain what each line does and how it does it . Analysed large demographic datasets using Python and PySpark in Cloudera and Hue . Provide ad hoc statistical and programming support . Attend consultations with academic advisors and assist in the interpretation of ideas to team members . Developed new methodology for uncertainty measures for population estimates based on administrative data . Other statistical methods and concepts applied in this role include generalised linear models , generalised additive models , survival analysis , k means and hierarchical cluster analysis , simulation , and probability density functions . . I have more than 20 years of experience in mathematics and statistics with a wide range of applications , including finance , Actuarial Science , cell biology , gene expression , pharmaceuticals , biometry , complexity science , and demography . I graduated from the University of Southampton with a 1st class degree in Mathematics , and went on to gain an MSc in Biometry statistics applied to biological data , with distinction , from the University of Reading . I applied my knowledge as a statistician at the University of Reading , working on consultancy projects , and teaching at a range of levels . I completed my PhD in Applied Mathematics at the University of Southampton . In the first year of the integrated PhD I followed an MSc in Complex Systems Simulation , for which I obtained a distinction . I then developed considerable expertise in stochastic models in biology , resulting in significant research output from my PhD in world leading journals , including Physical Review Letters , Nature Cell Biology , and Biophysical Journal . I spent a year at the Duke NUS Medical School , in Singapore as a Research Fellow , analysing high dimensional gene expression data in cancer cells . I then returned to the UK to work as a consulting statistician contractor at the Office for National Statistics in the UK . I am open to statistical and data science roles in Europe and the USA . I enjoy programming in Python , R and Matlab , and am comfortable working in development environments , including Git , GitLab , Linux , and remote virtual machines .. Technologies :",
"Principal Scientist . . Creative , adaptive , self motivated , quick learning , and innovative scientist who has been a dynamic team member within multiple small molecule drug discovery research organizations delivering clinical candidates .. Technologies :",small molecules
PhD Student and Graduate Teaching Assistant . Pursuing a PhD in Chemistry in the lab of Dr. Steve Reichow at Portland State University . Serving as a Lead Graduate Teaching Assistant for upper division biochemistry laboratory courses . . I am a PhD student at Portland State University studying vision and ageing with cryo electron microscopy . I have prior research experience in the application of X ray Crystallography to study blood coagulation proteins at Western Washington University .. Technologies : Xray;CryoEM,proteins;structure
"Postdoctoral Researcher . Visual Proteomics , Department of Molecular Sociology Beck group . I am an experienced and versatile cryo electron microscopist , with broad experience in many cryoEM techniques , particularly in single particle analysis and cryoCLEM . I am passionate about using my expertise in and further developing various electron microscopy techniques to help scientists answering their research questions . I combine a technical background with good personal and excellent communication skills . I am easy to get along with , eager to learn , organisedand enjoy interacting with scientists in an international environment .. Technologies : CryoEM",structure
"Postdoctoral Fellow . . I am a quick learner and passionate about tackling new problems . I have studied the molecular machinery for both photosynthesis and respiration during my PhD using an array of biochemical and biophysical techniques , such as enzymatic activity assay , ligand binding titration , electron paramagnetic resonance , time resolved optical spectroscopy . From these training , I truly believe the key to cure any disease or engineer any microbe is to understand the function of molecular complexes at the microscopical level . Currently , I am applying computational methods to study membrane protein complexes with the help of experimental data from cryo EM .. Technologies : CryoEM",membrane proteins;interaction;structure
"Principal Bioinformatics Scientist . . Experienced scientist with a demonstrated history of working in the biotechnology industry . Skilled in Mathematical Modeling , Matlab , Python , Bioinformatics , and Computer Science . Strong information technology professional with a Doctor of Philosophy PhD focused in Computer Science from University of Tasmania . . Technologies :",
"Senior Science Fellow . . 20 years of experience as a medicinal chemist and project leader Bayer AG Proven success at advancing multiple programs through all phases of drug discovery : hit validation , hit to lead , lead optimization and candidate selection Track record in many indications , cardiology , hematology , thrombosis research , bacteriology , virology , oncology , diabetes research , parasitology AH Expertise with many modalities aside from std . SMOLs : peptides , peptidic and SMOL prodrugs , peptide drug conjugates , antibody drug conjugates , molecular glues Acquaintance with HTS , structure , fragment and DEL based projects Interest in Mixed Modalities , Molecular Glue , Antibody Drug Conjugates ADCs , non viral Vectors , Lipid Nano Particles LNPs Management experience with in house chemistry teams , contract research organizations CROs and academic partners and nonprofit organizations : DnDI , IVCC , BMGF , IMI Sophistication in lab automation , software design and IoT based lab of the future . Technologies :",molecular glues;small molecules;peptides;developing;screening
"Scientist . . An experienced , high performing Synthetic Organic Medicinal Chemist adept in the art of organic synthesis and medicinal chemistry with over 14 years of experience in small molecule drug discovery . Proven ability to work within a multi disciplinary team to drive research programs toward successful conclusions . Skilled in the design and execution of multi step syntheses of targeted molecules ranging from milligram to multi gram quantities Proficient with modern spectroscopic 1 D and 2 D NMR , LC MS , HPLC , GC MS and chromatographic flash chromatography , TLC , chiral and reverse phase HPLC methods Prepared presentations and routinely presented and discussed research with medicinal chemistry department during monthly group meetings Experienced in kinase , transporter , tryptophan hydroxylase and phosphodiesterase and additional enzyme targets for immunologic , ophthalmic , and metabolic indications Working knowledge of ADME and pharmacokinetics Interpretation of SAR as applied to lead optimization of advanced targets Knowledge of chemistry related software CambridgeSoft Chemdraw , CAS SciFinder , Reaxys , MDL ISIS Draw and ISIS Base , ACD find , ACD Spectrus Processor and Discovery Studio . Technologies : NMR",small molecules;developing
"Director of Scientific Computing . Algorithms for cancer diagnosis ; genomics and variation analysis ; biological databases and high performance computing . . Experienced software systems architect and computational biologist specializing in high throughput data analysis systems for molecular diagnostics , genomics metagenomics , materials science , security , media , and finance . Human and non human genomic analysis , with a specialty in functional gene annotation and clinically relevant mutation classification . Extensive experience with AWS . Embedded systems experience in C and C . Technical leadership and experience working on cross functional core teams . DBMS and enterprise security expertise including HIPAA , with emphasis on networked , parallel , and distributed systems . Database internals and non relational data stores . Whole system hardware and software design and implementation , with particular care given to simple , reliable architecture and thorough documentation . iOS application development , along with corresponding backend processing . Machine learning approaches for the analysis of large amounts of structured and semi structured data . Systems for the design of novel biomaterials . Specialties : structural and synthetic biology , multithreaded multicore design , systems design , biomedical informatics , HPC , materials science , media video audio processing , and startup culture .. Technologies :",
"Associate Scientist . . I graduated from San Jose State University in 2018 with B.S. in Biological Sciences concentration in Systems Physiology and a minor in Chemistry . Currently , I am pursuing a M.S. in Bioinformatics at San Jose State University . I am a highly motivated and driven individual with years of experience in healthcare and biotech pharmaceutical industry alongside an academic background comprising life and computer sciences . I am well versed in quality control , wet lab analysis , and team leadership . I am currently looking for opportunities to further my career in the biotech and pharmaceutical industries .. Technologies :",
"Biochemist . . Master of Science in Engineering , Biotechnology Cand . Polyt . ; Biotechnology , Elite programme in protein biophysics , and PhD Medicine . Seven years of experience of planning , designing and conducting research as well as analysis , evaluation and documentation of results . Strong networking and communication skills both in Danish and English due to many years of collaboration with international partners and presentation of projects on international meetings and conferences . Broad knowledge in biomedicine , neuroscience , biochemistry , protein chemistry , molecular biology , analytical chemistry . Experienced in supervising and instructing technicians and students in the laboratory , planning and presenting chemistry lectures for medical students and chemistry high school . Technologies :",proteins;characterization
"Computational Biology PhD candidate . PhD Candidate in Drs . James M. Briggs s and Mehmet Sen s Labs at University of Houston Utilize supercomputer clusters at the research computing data core RCDC operated by The Hewlett Packard Enterprise Data Science Institute HPE DSI at the University of Houston for performing research simulations . Routine use of command line interface tools and programming languages Terminal , Vim , Python , R , C for data analysis . Projects : Perform ed metadynamics simulation for proteins including leukointegrin CD11c CD18 and Universal stress protein UspA616 incorporating nuclear magnetic resonance NMR , small angle X ray scattering SAXS and cryogenic electron microscopy Cryo EM data . Performed molecular dynamic simulations and small molecule complexed simulations for liver X receptor LXR protein . Experienced Researcher with a demonstrated history of working in the biotechnology industry with a strong background in Assay development . Skilled in Cell Culture , qPCR , Cell Based Assays , ELISA , SDS PAGE and other Biotechnology techniques . Strong research professional with a Master 's Degree focused in Clinical Laboratory Science Medical Technology Technologist from University of Massachusetts Lowell . Currently pursuing a PhD in Biochemistry at University of Houston .. Technologies : Xray;CryoEM;NMR",
"Team Leader , Senior Scientist . . I have 8 years of solid scientific experience in protein biochemistry and protein purification for crystallisation . During my work experience from academia and industry I gained some high expertise in membrane GPCR , Transporter and soluble proteins enzymes , antibodies , ... . I have set up and optimise some process for protein expression , reconstitution proteoliposome , nanodiscs , purification Chromatography and functional characterisation binding assay , ELISA , fluorescence spectroscopy , SAXS , FT IR , DLS , ... . Expert in : Protein Purification ; FPLC ; Heterologous expression of Membrane and Soluble protein in Yeast , bacteria , mammalian cell ; Radioligand Binding Assays ; Fluorescence Quenching , Labelling , ELISA ; Molecular biology ; Plasmid construction ; Mutagenesis ; Nanodiscs ; Proteoliposomes . Technologies : SLS DLS",antibodies;membrane proteins;proteins;characterization;expression;interaction;structure
"Postdoctoral Researcher . Using cryo electron tomography to study cellular structures in unprecedented detail . . Collaborative scientist and communicator with 10 years of experience in cell and developmental biology . Currently using cryo electron tomography to study cellular structures within diverse organisms . Skills include research , teaching , mentoring , and producing engaging scientific content for wide ranging audiences .. Technologies : CryoEM",structure
"Scientist . . I am a highly motivated and results oriented scientist . In Industry , I have worked with many projects to characterize interactions between protein drug candidates and their target molecules as well as genetic engineering and mammalian cell line development for antibody production . During my time in academia , I worked with protein engineering where I developed several new methods and concepts for engineering and characterization of proteases and affinity proteins . . Technologies :",proteins;small molecules;expression;interaction
Scientist I . . . Technologies :,
"Marie Curie Early Stage Research Fellow . One of the 14 ESR research fellows in the H2020 MSCA ITN project AiPBAND An Integrated Platform for Developing Brain Cancer Diagnostic Techniques . Dr. Xiaoyu Zhang is a Marie Curie ESR Fellow at Imperial College London . His current research interests include machine learning , medical AI , and bioinformatics .. Technologies :",
Staff Research Scientist . Thomas C. Marlovits Laboratory cryo EM specialist . . Technologies : CryoEM,structure
GPCR Drug Discovery Scientist . . . Technologies :,
"Assistant Professor , UCD School Of Medicine . . I am a medical graduate and obtained my Ph . D. in Immunology from Umea University , Sweden in 2007 . I am the Translational Research and Engagement Manager for Precision Oncology Ireland POI , based in UCD , Dublin Ireland . I run the Tissue Imaging Platform for POI . Our main focus is on cancer biomarker development using digital pathology . We use IHC , ISH , Multiplexing , and both quantitative and advanced AI based image analysis algorithms for tissue based biomarker development . We put particular attention on commercial antibody validation . . Irish Cancer society award winner Senior Researcher of the Year 2020 . UCD Value in Action VIA award winner 2020 . . Technologies :",
"Principal Bioinformatics Scientist II . . Designed and developed computational tools for novel discoveries of driver genes used internally for drug target discovery and experimental design . Performed downstream genomic data analysis and integrated system biology level data resources gene essentiality , synthetic lethality , pathways to prioritize potential cancer drug targets . Processed and analyzed pharma related Big Data for Drug Repurposing . identified approved drugs with potential new disease areas Applied machine learning techniques e.g. , regression , k means , random forest , and PCA to predict drug side effects . Developed data pipelines to incorporate acquire , clean , link , process , and organize data from diverse databases . Acquired ten years of experience with software development for data manipulation and analysis . developed NMSim and RCNMA ; published in scientific journals and being used at Merck KGaA. Designed and developed web servers and data resources using data mining , algorithm development , statistical analysis , data modeling and predictions . www.bindingmoad.org provides the specialized biochemical data and visualization . www.nmsim.de provides protein modeling and simulations for user submitted jobs . Conducted and analyzed benchmark exercises in the Community Structure Activity Resource www.csardock.org improved 200 user participation by data mining relevant users and advertising . Attained solid background in programming C C Python Perl Fortran R Java Linux , data analysis tools R , JMP , MS Power Pivot and databases MySQL , Oracle . Published 11 peer reviewed articles in reputed scientific journals , written grant proposals , and presented results in many conferences .. Technologies :",
"Senior Director Protein Sciences . . Structural Biologist Biophysicist with 12 years of experience in membrane proteins . Focus on structural dynamics and mechanisms of action of ion channels and transporters . Experienced in designing and expressing constructs , biochemical and spectroscopic analysis and structure determination . Productive in project leadership and in collaborative effort , highly organized and goal oriented .. Technologies : Xray;CryoEM",membrane proteins;characterization;structure
"Group Leader , Senior Principal Scientist . Medicinal Chemistry , Head Specialized Chemistry Technologies . Roche Pharma Research and Early Development pRED , Medicinal Chemistry , Roche Innovation Center Basel . Rainer E. Martin , PhD , is a Senior Principal Scientist and Group Leader heading the chemistry technology group in Medicinal Chemistry at Roche Pharma Research and Early Development pRED , Roche Innovation Center Basel Switzerland . In his current position , he is committed to modern leadership according to the VACC principles . Scientifically , he focuses on modern synthesis technologies with a focus on parallel , flow and electrochemistry . . Rainer received his PhD in organic chemistry from ETH Zurich in 1998 and spent two years as a postdoc at the University of Cambridge UK , supported by a grant from the Swiss National Science Foundation SNF and a Junior Research Fellowship from Churchill College . He joined Roche in 2000 , initially working in formulation research , before moving to Discovery Chemistry in 2002 . Since then he has been working on various projects that covered a wide range of disease areas . . Specialties : Drug discovery , polymer chemistry , lead generation and lead optimization , chemistry technologies flow chemistry , photochemistry , electrochemistry , late stage functionalization , parallel synthesis and screening , antibody drug conjugates ADCs , outsourcing collaborations . . Academic Visitor at the Innovative Technology Centre ITC in the group of Prof. Steven V. Ley , Department of Chemistry , University of Cambridge , UK . Research in the field of flow chemistry . . Technologies : ITC",antibodies;small molecules;screening
"Senior Director , Bioinformatics and Data Science . . Creative and highly motivated manager and data scientist specializing in RNA biology and small molecule drug discovery , from target identification through biomarker validation . Strong group leader , communicator , and collaborator .. Technologies :",
"ML Science Manager . . We are hiring ML scientists at all levels with background or interest in adversarial ML , online and offline RL , sequence modeling , large graph analytics , and cybersecurity analytics . If you are interested please share your resume or apply here : https : lnkd.in e38DVSS2 amazon hiring ml rl graph artificialintelligence cybersecurity . Technologies :",
"Senior Scientist . . Pursuing a role as a scientist in synthetic biology , computational biology , or related fields . . Technologies :",
"Principal Scientist . Leading assay development , validation and regulated bioanalysis platforms : Ligand binding assays , including ADA assay MSD . Cell based immunogenicity assays , including NAb assay and ELISpot assay . qPCR assays , including viral shedding assay . Developing bioanalytical strategies for gene therapy programs . 2 . Managing CROs Leading evaluation reassessment of CRO s capabilities in supporting regulated bioanalysis and lab audits . Managing assay development , qualification , validation , and bioanalysis for clinical studies conducted at CROs in the US , Canada , UK , and France . 3 . Representing bioanalysis in cross functional teams Contributing to internal cross functional meetings with Research , Pharmacology , Toxicology , CMC , clinical operation and clinical development . Contributing to external team meetings with central lab and clinical trial managing organization , including sample collection processing instructions in the lab manual , and DTA drafting , reviewing , and implementation . Facilitating sample tracking among clinical sites , central lab , and bioanalytical CRO labs for global clinical studies . 4 . People management and in house biomarker bioanalytical assay development validation Leading a scientific team to develop in house large molecule biomarker assay and viral shedding gene therapy assays . Equipment evaluation , purchase , set up , training and maintenance . Evaluating new technologies . Contract managing and negotiating . . A highly motivated team lead and scientist with excellent strength in quick learning , strategic analytical thinking , ideation , intellection , problem solving , and people management . Lead assay development , validation and regulated bioanalysis of immunogenicity ADA , NAb , and T cell response , biomarker , and viral shedding assays in gene therapy drug development . Oversight of external CRO partners Strategic planning of resources and ensuring high quality deliverables within timelines in support of key stakeholders Experienced in representing bioanalysis in cross functional teams . Excellent written and oral communication skills . In depth knowledge in Drug development , both gene therapy and small molecule FDA EMA Guidance , including Bioanalytical Method Validation , Immunogenicity , Viral shedding Prism , Abase and Biovia Electronic Notebook ELN . Technologies :",carriers;proteins;expression
Research Scientist Manager . . We are hiring . Technologies :,
"Director , Computational Biology . . . Technologies :",
"Senior Director , Bioinformatics . Building and leading a cross functional team supporting the development of a revolutionary molecular analysis platform . . Computational Biologist with 20 years of professional software engineering experience and expertise in Next Generation Sequencing , Machine Learning , and Clinical Bioinformatics . Currently Senior Director of Bioinformatics building and leading a team to support the development of revolutionary scientific instrumentation . Formerly Director of Engineering at DNAnexus , Principal Scientist at PGDx now LabCorp , and an American Diabetes Association Postdoctoral Fellow at the NHGRI in Dr. Francis Collins ' laboratory . Current publication list on Google Scholar . Specialties : Experimental design and analysis of genome scale data using cloud technologies . Software engineering in Rust , Scala , Python , and R. Bioinformatics tools and methods .. Technologies :",
Visiting Scientist . . . Technologies :,
"Senior Scientist Lab Head , Roche Pharma Research and Early Development pRED . Responsible for characterization of therapeutic antibodies and next generation biologics using mass spectrometry and biochemical analytics . Additional focus on laboratory hardware IT automation workflows and high throughput approaches . Leading a lab with three research associates , two IT scientists and a postdoctoral research scientist . Working in or leading therapeutic research and early development , as well as technology project teams in a matrix environment . . Senior scientist with more than 10 years of experience in protein biochemistry and analytics , focusing on mass spectrometry , high throughput approaches and lab and IT automation . Working on therapeutic antibody portfolio and technology projects both as a lab head as well as in a dynamic matrix environment . . Technologies :",antibodies;biologics;characterization;screening
"Director of Clinical Informatics Data Science . Lead a team of clinical data managers and clinical data analysts for clinical studies and clinical trials . . Broad knowledge in biological data analysis NGS , single cell sequencing , microarray , genetics , and genomics and algorithm development . Solid track record in supporting assay and product development . Experienced manager of building and managing bioinformatics teams . Extensive experience in working with multiple functional groups .. Technologies :",
"Senior Scientist I , protein engineering . . Highly motivated and skilled protein biochemist and structural biologist with over four years of post graduate experience in academia . Expertise in X ray crystallography and cryo electron microscopy , protein purification from a variety of expression systems E. coli and S. cerevisiae , and protein biochemistry to probe intermolecular interactions . Exceptional leadership abilities as evidenced by both individual and group management roles . Outstanding written and oral communication skills as demonstrated by numerous presentations . Efficiently works autonomously or as part of a cross functional team , as shown by multiple independent and collaborative projects resulting in high profile publications .. Technologies : Xray;CryoEM",proteins;engineering;interaction;structure
"Postdoctoral Researcher . Cell to cell communication via plasmodesmata , cryo electron microscopy on proteoliposomes , interactomics . Experienced Doctoral Researcher , graduate from University of Montpellier , with a demonstrated history of working in academic research . Microscopy and all kinds of shiny , bright proteins fan . From macro to super resolution . Fundamental plant cell biologist that fundamentally loves all animals as well .. Technologies : CryoEM",proteins;structure
Principal Scientist . . . Technologies :,
"Newcastle University Academic Track NUAcT Fellow . . I am a Newcastle University Academic Track NUAcT Fellow . I am part of the Brain and Movement BAM Research Group at the Translational and Clinical Research Institute of Newcastle University and I have been contributing to build the digital health theme within the group . I also serve as the Innovation , Methodology and Application IMA Early Career Researchers representative within the IMA theme and in 2022 I have been elected Chair of the Early Career Researchers Working Group of the BioMedEng association Council . I am an Associate Editor for the IEEE Journal of Biomedical and Health Informatics IEEE JBHI . My expertise and translational research interests focus on digital health . In particular , I am interested in the use of wearable technology and in developing analytics for quantification of digital mobility outcomes in ageing and neurodegenerative diseases e.g. Parkinson 's disease , to enhance remote monitoring and clinical management . I have been involved in the V TIME project : Virtual reality Treadmill combined Intervention for enhancing Mobility and reducing falls in the Elderly . The project ended in 2015 ; findings of the study have been published in The Lancet https : www.thelancet.com journals lancet article PIIS0140 6736 16 31325 3 fulltext . I am currently involved in the Mobilise D project as a task leader . The project aims at connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement . The project is funded by the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 820820 . This Joint Undertaking receives support from the European Union 's Horizon 2020 research and innovation programme and EFPIA . Website : http : www.mobilise d.eu . Technologies :",
"Head of Scientific Partnerships , Data Sciences Platform . Build partnerships focusing on accelerating science through software engineering at the Data Sciences Platform . Educate partners about the solutions and capabilities of the Data Sciences Platform through demonstrations and presentations . Define solutions with corporate and government funding partners to serve scientific initiatives . Represent the scientific community when evaluating market needs and program direction . Identify funding leads and evaluate those leads in the context of our current project portfolio . Author letters of interest , proposals and funding applications . Coordinate with stakeholders and internal teams to define a statement of work as projects are funded and yearly thereafter to guide execution . As a Principal Investigator , Investigator , or lead on funded initiatives , maintain oversight during the life of funded projects . Review team work and demoes to assure milestones are met as defined in the statement of work . Risk manage milestones and delivery of work with stakeholders and internal teams . . I am passionate about bringing together data science and software engineering to accelerate science initiatives . Leveraging extensive experience with Next Generation Sequencing NGS assays , I have broad experiences in creating portals , cloud native data centers , scalable analysis pipelines , and data modeling to support a variety of scientific initiatives . Most recently , leading projects focusing on single cell genomics , previous experiences include de novo assembled and reference based population derived RNA Sequencing methodology specifically variant calling and fusion detection , analysis of metagenomic data sets WGS and 16S , statistical techniques for microbial biomarker detection in sparse high dimensional data and the application of array technology to ovarian tumor research .. Technologies :",
"Research Fellow . Metagenomics : integrative analysis of multi omics data from a large cohort Gut tissue single cell transcriptomics data analysis Spatial transcriptomics data analysis and method development . An experienced computational biologist with strong passion for understanding biology with computational approaches . Proficient in mining , visualizing , interpreting and modeling high throughput sequencing data . Interested in a broad range of biological problems , especially understanding the dynamics of microbial communities . Recent CV : https : github.com lch14forever CV raw master cv.pdf . Technologies :",
"Senior Researcher . . I am a highly enthusiastic and motivated senior research scientist . My strength lies in my multidisciplinary background . I have a strong theoretical knowledge base in Biological Sciences , Biochemistry , Pharmaceutical sciences and experience in Computational modeling and simulations of biomolecules . I work in an interdisciplinary environment , where I am able to combine both experimental knowledge and computational predictions to understand better the fundamental nature of the biological processes at the molecular level . . My research involves computational modeling of 3D structures of proteins , development of prediction protocol for identification of food derived taste peptides , and establishing computational methods to accurately predict the binding mechanism and selectivity of taste receptors G Protein Coupled Receptor to endogenous peptides and food derived taste peptides . Previously , I have been involved in studying the membrane protein simulations , predictions of antibody structure , antibody antigen docking and simulations , in silico and in vitro design of high affinity antibodies , . In my research , I have used different computational software suits such as Rosetta for structure predictions , protein protein docking , Molecular dynamics software such AMBER , NAMD , Gromacs , and Schrodinger software package , data analysis tools . I have gained experience in programming : advanced bash scripting , Python , R script , and Linux operating system . I defended my Ph . D. thesis titled : Molecular modeling and simulations of protein , membrane and ligand interactions on 13 12 2017 with Magna Cum Laude under the supervision of Prof. Rebecca Wade in the Molecular and Cellular Modelling MCM group at the Heidelberg Institute of Theoretical Studies HITS gGmbH and co supervision of Prof. Christian Klein , director IPMB Medizinische Chemie , Universit t Heidelberg . I did my Postdoc in the B Cell Immunology group at German Cancer Research Centre , under the supervision of Prof. Hedda Wardemann and currently working as a senior research scientist in the group of Molecular Modeling group headed by Dr. Antonella Di Pizio . My area of specialties include : . 1 Molecular modeling of 3d structures mainly for antibodies . 2 Protein protein interactions : antibody antigen and GPCR peptide . 3 Molecular docking of small molecules agonist , antagonist , . 3 In silico and in vitro antibody affinity maturation . 5 Multiscale simulations of biological membranes , protein membrane , protein protein interactions . 7 Data analysis in R , Programming with Python , Bash , Linux . Technologies : Xray",
"Guest Editor . . My research is mainly to develop methods to unveil the hidden biological circuitries underlying the data , from understanding sequence based regulations to the genomes or proteome and their impacts to diseases , including : i Decoding genomic sequence to decipher connections between sequence , functions , and phenotypes , especially leveraging sequence data and deep learning models ; ii Developing new approaches for prioritizing actionable mutations characterized human diseases ; iii Investigating gene expression patterns in human traits diseases utilizing epi genomics data ; iv Data integration , database construction , webserver platform development ; v Multi omics data analysis and a variety of bioinformatics statistical modeling .. Technologies :",
"Associate Professor . The major focus of my research is on membrane protein structure , function and dynamics . Using a combination of biophysical techniques , including X ray crystallography , absorbance spectroscopy , X ray scattering and X ray free electron laser biomolecular imaging , we study proteins and enzymes at work . I am particularly interested in two groups of membrane proteins ; energy converting enzymes such as cytochrome oxidase and reaction center , and drug discovery related proteins such as the antibiotic target MraY involved in bacterial cell wall synthesis and the cytochrome P450 protein family . I am involved in developing novel structural X ray methods and have an interest in how these can be applied to structure based drug design . . I am a structural biologist biochemist with experience from pharmaceutical industry . I am leading a research group at the Department of Chemistry and Molecular Biology at the University of Gothenburg . The focus of my research group is protein structural dynamics and structure based drug design with a special focus on membrane bound proteins . We use a combination of different biochemical and biophysical methods such as X ray crystallography , absorbance spectroscopy , X ray Scattering and serial crystallography using X ray Free Electron Laser XFEL and synchrotron radiation . We are particularly interested in energy converting systems of the cell including the respiratory enzyme cytochrome oxidase , and antibacterial protein targets . Link to publications : www.researchgate.net profile Gisela Braenden publications . Technologies : Xray",membrane proteins;interaction;structure
"Epidemiologist . Public health research with Travis C. Porco and Thomas M. Lietman . . I use mathematical models , statistical analysis , and software simulations to investigate collective behavior of populations and communities . Ongoing research includes disease transmission dynamics , emergence of cooperation in repeated interaction between individuals using old school game theory in unorthodox ways , how a diverse ecosystem can coordinate sustainable use of resources using fairly common mathematical models of evolutionary ecological dynamics in an unusual way and how a network of people can sort through a set of competing options collectively by exchanging information locally using models of stochastic dynamics on networks . Specialties : deterministic and stochastic dynamical systems theory , theoretical population biology , individual and agent based modeling , science and technology studies For publications see https : scholar.google.com citations hl en user ZLkVeQsAAAAJ . Technologies :",
"Executive Director , Head of Research and PreClinical Development IT . . . Technologies :",
"Manager in Chemical Biology . . Passionate , full of energy and with a thirst of understanding how things work , Jonathan Fauerbach is a citizen of the world , where friends equal family , and family means the world to him . His curiosity inevitably leads him to study Chemistry , where he obtained a Ph.D. in Organic Chemistry and Protein Biophysics from the University of Buenos Aires in Argentina and the Max Planck Institute for Biophysical Chemistry in Getting , Germany . His studies in Germany allowed him to develop novel fluorescent organic reporters with unprecedented sensitivity to protein folding which he applied to the study of alpha synuclein protein misfolding and in vitro aggregation in relation to Parkison s disease . He had the chance to present his work in more than XX conferences and establish collaborations around Europe . In particular , his collaboration with Prof Dr. Wah Chiu led to depicting alpha synuclein intermediates critical in fibrillar genesis and propagation through 3D Cryo EM . Jonathan also developed an interest for nanomaterials and nanoparticles . Soon after his thesis defense on July 2013 , Jonathan joined the Frydman Lab at Stanford University as a Postdoctoral Fellow . Mentored by Prof Judith Frydman , he has focused on biochemical and cellular biology aspects of the Huntingtin protein misfolding , oligomers and protein protein interactions with chaperones and protein quality control systems in cellular models of Huntington s disease . He has also worked on developing biocompatible Photoluminescent Silicon Nanoparticles for targeted live cell imaging and small drugs and peptides delivery . In his free time , Jonathan has led a Multicultural Movie cycle at Stanford , as well as joined and became the President of the Argentine Student Organization with Annual cultural exchange events . He also forms part of an Argentinean Rock Band , called 1818 , and intensely enjoys life in the presence of his wife and son . Creativity and happiness surround his life .. Technologies : CryoEM",idps;proteins;interaction
"Cryo EM microscopist and Biochemist . . Currently looking to review papers in the fields of cryo EM , TEM , Structural Biology virology and allied life science fields . Publons profile https : publons.com dashboard records review My expertise mainly involves working with viruses using multiple flavors of Cryo Electron Microscopy . Additionally i have also use biochemistry , protein engineering , antigen antibody interactions , and bispecifics in my research . I am proficient using structural biology allied softwares for data analyses . I have recently joined he Pacific Northwest National Lab as a Cryo EM Biochemist .. Technologies : CryoEM",antibodies;proteins;engineering;interaction;structure
"RNA Fellow . . PhD Candidate with basic research experience in molecular biology , RNA sequencing , and small molecule drug discovery , and computational experience studying alternative splicing and differential gene expression in the context of SARS CoV 2 and Myotonic Dystrophy .. Technologies :",small molecules
Chercheur postdoctoral . Cryo electron microscopy study of membrane protein in the Axel Innis 's lab . . Technologies : CryoEM,membrane proteins;structure
Senior Postdoctoral Fellow . Head of team BioPOLIM . My research focus is on application and further development of fluorescence polarization microscopy techniques and complementary marker free nano infrared spectroscopic NanIR imaging for investigation in Life Sciences . The research focus of my team BioPOLIM is on application and further development of fluorescence polarization microscopy techniques and complementary marker free nano infrared spectroscopic imaging for investigation in Life Sciences For current projects and my research experience see our team homepage : http : biopolim.de . Technologies : FP,
"Research Scientist . Project management and scientific project lead , NMR based screenings and labelled protein QC . Structural biologist specialized in high resolution NMR . Expert in structural based drug design , characterization of protein DNA and RNA molecular complexes Biophysics facility manager , focused on NMR , ITC , MALS and DLS Teacher of computational chemistry and NMR spectroscopy Advanced skills in recombinant protein production Additional experience in virtual screening , docking and molecular dynamics Linux admin with focus on data consolidation and supercomputing Scientific supervisor and coordinator Data analyst with knowledge of Python , R and hands on SQL database systems Team player and team motivator Independent and goal oriented .. Technologies : ITC;SLS DLS;NMR",nucleic acids;proteins;characterization;interaction;screening;structure
Genome Scientist . . Experienced computer biologist with extensive experience of annotation and analysis of eukaryotic genomes .. Technologies :,
"Senior Vice President for Research . Responsibilities now include oversight for JAX 's Genomic Education programs in partnership with VP for Education . . Strategic , innovative and entrepreneurial leader with more than 30 years experience managing collaborative research team science , designing and implementing scientific research strategies and applying technology and information science to advance biomedical research and biopharmaceutical businesses . Advised leading university on coordinated , multi school initiative on individualized healthcare research and delivery . Led unique , collaborative translational research programs in oncology and neurology . Developed state of the art bioinformatics and cheminformatics platforms for top 10 pharmaceutical company . Promoted the development and application of emerging technologies , such as text mining and visualization of large , multidimensional data sets big data .. Technologies :",
"Expert Research Associate Lead Generation . . Research associate with 6 years of experience working independently , as well as participating in collaborative group projects . Skilled in cell biology , molecular biology , and biochemistry methods with training in single particle cryo EM .. Technologies : CryoEM",proteins;structure
"Research Associate . Currently working as Research Associate at Cryo EM CORE facility at UT health McGovern Medical School . Responsibilities include high resolution Cryo EM data acquisition , Sample grid preparation and screening , Carbon evaporation , Scheduling users , Orders and general maintenance of core facility . . Experienced Senior Research Assistant with a demonstrated history of working in the hospital health care industry . Strong research professional skilled in protein biochemistry , molecular biology and microscopy . . Technologies : CryoEM",proteins;structure
"Senior Principal Scientist . Small Molecule Drug Discovery Novel Drug Modalities : Protein Homeostasis Targeted Protein Degradation . I 'm a highly experienced synthetic organic chemist with expertise in natural product total synthesis , small molecule drug discovery , and protein homeostasis . I have a strong track record of innovation and impact as well as excellent written and verbal communication skills as demonstrated by a consistent patent , publication , and presentation record . Beyond science , my professional passions include teaching and mentorship as well as advocating for greater recruitment , inclusion , and retention of women and under represented minorities in the chemical sciences .. Technologies :",molecular glues;proteins;small molecules;screening
"Senior Scientist . Liposome Liposomal Drug Delivery System Nanoparticle Asymmetric Symmetric Liposome Phospholipid Cholesterol Cyclodextrin Virus Structure Lipid Rafts Cell Membranes Fluorescence FRET Immunoassays ELISA High Throughput Screening Systems Chromatography New Technology Implementation Formulation Bioconjugation Small molecule Preparing and characterizing small molecule trapped liposomal delivery system to increase sensitivity specificity in new and existing immunoassays ; Four employee invention disclosures submitted Designing , formulating , and characterizing small molecule trapped liposomes nanoparticles with modified functional surface . Biophysical biochemical characterization and stability evaluation of peptides , proteins , polymers , antibodies , bioconjugation , magnetic particles , liposomes , nanoparticles , etc . Developing immunoassays to detect specific antibody that interacts with antigen on automated high throughput screening systems Generating signaling molecule trapped liposomes to increase sensitivity specificity in new and existing immunoassays Optimizing reagent formulation , bioconjugation , buffer system , preservatives , blocking proteins , detergent , and paramagnetic microparticles Responsible for training associate scientists Trained for Six Sigma Black Belt Certification . Expert in design , fabrication , formulation , and characterization of delivery systems for drugs small molecules biologic therapeutics e.g. , model membranes , liposomes , liposomal nanoparticles , nanoparticles , artificial cell membrane , microspheres , PEGylated non PEGylated nanocomplexes , etc . ; Four Patents submitted Well versed in analytical method development and biophysical characterization of protein peptide liposome nanoparticle and their interactions bindings using fluorescence spectroscopy , AUC , NMR , HPLC , Dynamic Light Scattering DLS , and chromatography Senior scientist in early late stage immunoassay development with solid experiment skills and analytical instrument knowledge in the fields of immunology , biophysics , structural biology , biochemistry , drug development , and biomaterials Inventor of of dietary supplements for preventing arthritis ; Patent issued Inventor of liposomes with small molecule system to enhance sensitivity specificity in immunoassays ; Four patent applications submitted . Technologies : SLS DLS;AUC;NMR;FRET",antibodies;carriers;peptides;proteins;characterization;screening;stability
"Director , Knowledge Systems Group ; Principal Scientist , Dept . of Data Sciences . Lead team of 30 Computational Biologists and Software Engineers in building software tools and products for cancer genomics research and precision cancer medicine . Principal Investigator for two NCI Moonshot Big Data Initiatives : the Cancer Immunologic Data Commons CIDC , and the Human Tumor Atlas Network HTAN Data Coordinating Center DCC . Co Principal Investigator for the cBioPortal for Cancer Genomics , the most widely used analysis and visualization tool for cancer genomics data . Spearhead development of MatchMiner , an open source clinical trial matching software platform for precision cancer medicine . Winner of 2016 Harvard Business School Clinical Trials Competition and 2017 BioIT Best in Show . Lead R D development for multiple clinical molecular assays , including OncoPanel NGS Assay and ImmunoProfile Multiplex Imaging assay . Key leader of the AACR GENIE Data Sharing Project corresponding author on first GENIE paper , published in Cancer Discovery . Key leader of the Intel Collaborative Cancer Cloud CCC Project to facilitate secure joint computation across multiple cancer centers . . As an innovative and accomplished bioinformatics leader , I have expertise in oncology and precision cancer medicine . I am highly skilled in software engineering , data architecture , databases , high performance computing , and cloud computing . As an excellent communicator , I am adept at building , leading , and mentoring strong performing teams to achieve organizational vision and objectives . Throughout my career , I have proven success in managing large portfolios of software projects , developing open source software , and executing informatics strategies to improve patient care . Areas of Expertise include : Data Analytics , Computational Biology , Cancer Genomics , Software Engineering , Bioinformatics , Scientific Computing , Agile Project Management , Machine Learning , Cloud Computing . Technologies :",
analytical scientist . . PhD in Sciences with specialization in Virology and practical experience in Somatic and Stem Cell Therapy Development . Domains of proficiency . Biochemistry : . o Flow cytometry ; . o Antigen capture ELISA ; . o Antibody capture ELISA ; . o Competition ELISA . . o Enzymatic activity measurement ; . o Western blotting ; . o Protein purification . Cell culture : . o Isolation and culture of primary mammalian cells ; . o Culture of mammalian and insect cell lines ; . o Recombinant protein production in insect cells ; . o 3 D cultures combined or not with biomaterials ; . o Cell differentiation assays . Molecular biology : . o RNA and DNA extraction ; . o RNA reverse transcription ; . o Real time RT PCR and semi quantitative PCR . Immunology and Virology : . o Seroneutralization tests ; . o Amplification of viruses in mammalian cell cultures ; . o Virus titration by the tissue culture infectious dose 50 TCID50 method and by plaque visualization . . Histology : . o Immunocytochemistry ; . o Histochemistry ; . o Immuno peroxidase monolayer assays IPMA . . Technologies :,antibodies;enzymes;interaction
". . I am studying membrane protein structure using Cryo Electron Microscopy . I am good at obtaining high quality monodisperse particles of membrane proteins . I worked in biochemistry and structure biology in the field of nucleotide excision repair , from which I mastered conducting p32 radio labeled nuclease assay .. Technologies : CryoEM",membrane proteins;structure
"Staff Scientist . . I am currently a Staff Scientist in Thermo Fisher Scientific , where I have been working for three years this includes a short pre acquisition period at Affymetrix . I have also spent four months as a bioinformatics analyst at Complete Genomics and three years as a post doctoral scholar at UC Davis . My recent work involves both custom data analysis and internal systems and software infrastructure . I am a team player and consensus builder , highly efficient at collaboration across departments . I have strong programming experience , mainly in R Python , but with some exposure to other languages Perl , PHP , PSQL , JS , C . My work is driven by a relentless curiosity about the internal workings of computational , biological , and organizational systems . I am a driven , adaptable learner , with extensive experience resolving challenging analysis problems .. Technologies :",
"Principal Scientist Bioinformatics . . I 'm a computational biologist with breadth of experience in processing and analyzing next generation sequencing NGS data to understand the mechanism of genetic variation across a genome within a single organism and depth of experience in the biological analysis of a single gene across many organisms . In particular , I have : Developed , optimized , validated and applied tools and workflows for processing and analyzing biological data To develop a better understanding of biological variation , built a computational pipeline to process analyze RNA seq data to identify variants and mutation patterns Introduced , evaluated and improved a Bayesian , population genetic , identification method that can assign unknown sequences to one of several known species groups Created a workshop for high school student to raise awareness of bioinformatics How would I describe myself Curious and possess a strong desire to learn Enjoy communicating complex concepts in the simplest possible manner Passionate about writing code to conduct analyses and working on problems that are going to matter Want to know more about me https : twitter.com mjjlou https : melaniejjlou.wordpress.com Email me at melanie.jj.lou AT gmail.com . Technologies :",
"Postdoctoral Researcher . Postdoctoral Researcher at the IECB , Bordeaux , France Team ' Structural Biology of Biofilms ' led by Petya Krasteva Funded by ERC grant ' Biomatrix ' . From gene to structure I am a biochemist focused on membrane proteins : proteins make the workforce of the cell , they assume all the biochemical tasks essential to Life . among them , membrane proteins MPs play a special part : they are the gatekeepers , filtering the fluxes of matter and information in and out the cells . They play key roles in a number of diseases . as such , the structures and functions of the MPs should be well understood of as they represent perfect drug targets readily accessible on the cell surface however this is not the case . MPs are difficult to study : MPs are embedded in biological membranes made of phospholipids ; they interface with the fatty acid chains by displaying a specific hydrophobic surface the hydrophobic belt . to study MPs , they first have to be solubilized out of their native membrane and into detergent micelles . detergents are often not compatible with biochemical and biophysical assays additionally , detergents may disrupt the structure and hence the function of the proteins they solubilize . New tools for studying the drug targets of the future The recent years have seen the development of new biochemical and analytical tools that allow for better and faster structural characterization of the MPs : Nanodiscs NDs : the structural integrity of MPs is better retained in a membrane nanodisc than in a detergent micelle micropreparative LC LC : MPs usually come in smaller quantities than the soluble ones . LC is a powerful tool to better isolate MPs . cryo EM : MPs seldom cristallize Cryo EM is the new workhorse of MP structural elucidation . nanobodies nAbs : small nAbs recognize structural epitopes and lock MPs in different conformations , boosting tandem structure function studies Through my career see below I have developed the skills and tools required to push the boundaries of MP research , a field that requires technical excellence , focus , stamina and open mindedness . . Technologies : CryoEM;CD",antibodies;membrane proteins;characterization;structure
"Senior Manager Global Regulatory Affairs CMC . . As Senior drug product coordinator , I am coordinating biopharmaceutical drug product formulation development and manufacturing activities . To be part of the development of a promising molecule into a launched drug is an exciting journey I have experience working within early phase up to phase I as well as late phase where submission for market and the following questions from the authorities have been in focus . Working with project management within Pharma is of course about getting a new product on the market , but also making a difference in interesting knowledge transfer processes externally and internally . It 's a pleasure being part of not only interactions with CMO CRO 's and project transfer to another company , but also internal transfers from Discovery to CMC and from CMC to Product Supply . Previously I have been working with project management within health and welfare technology , where I could use my educational background within pharmacy . My PhD thesis concerns protein aggregation , focusing on oligomerization and fibrillization in protein conformational diseases .. Technologies :",antibodies;proteins;formulation;stability
"Product Manager . Part of the global product management team of a family owned company , with the global responsibility for two stage oil lubricated rotary vane pumps , scroll vacuum pumps , vacuum measurement technology , and helium leak detection . . A nanoscientist specializing in cryo electron microscopy who now works in global product management for a family owned company , where he has global responsibility for two stage oil lubricated rotary vane pumps , scroll vacuum pumps , vacuum measurement technology , and helium leak detection .. Technologies : CryoEM",
"Postdoctoral Researcher . Protein biochemistry , Structural biology , cryo EM . . Technologies : CryoEM",proteins;characterization;structure
Principal Machine Learning Scientist . . Detecting cancer before it is too late .. Technologies :,
"Computational Biology Co op . . I 'm a project lead and software developer at Sandbox , studying computer science and biology at Northeastern University . I 'm currently looking for fulltime opportunities from July December 2022 , with passions in biotechnology and frontend fullstack web development . My areas of expertise include object oriented programming , front end development , and teamwork . Languages frameworks : React , Typescript , Node , Next , Java , MySQL , R , Vue , Python , Racket .. Technologies :",
Bioinformatics Architect . . . Technologies :,
"Professor of Neurosurgery , Neurology , and Biomedical Sciences . Board of Governors Chair in Neurosciences endowed chair Direct the human systems neuroscience group in the department of neurosurgery . http : www.rutishauserlab.org . Systems Neuroscience , Electrophysiology , Learning and Memory , computational and theoretical neurosciene , Data analysis , Algorithm development , computational modeling , machine learning , clinical neuroscience . Technologies :",
"Omics Data and Analytics Lead Director R D IT . . I am passionate about the patient , and I am motivated by making a difference to someone s life . I m inspired by great leadership and driven to deliver elegant solutions to complex problems that have the potential to improve human health . I enjoy using my skills to identify new insights offered by analyzing and integrating large multi omic data systems . My current goal is to continue to grow as a senior leader , developing and coaching junior staff and challenging them to execute and deliver in a quality manner . Leadership : 8.5 years people leadership via direct line and project leadership roles . Currently a manager of managers leading a function of 20 FTE split across data operations and software development . Lean Six Sigma Black Belt and champion , experienced influencer of other Snr Leaders . Understand the importance of the Voice of the Customer and Business to deliver appropriate data solutions . Experienced in storytelling with data .. Technologies :",
"Professor . Fibrillation and aggregation of proteins . General folding and stability of proteins . Biophysics of membrane proteins , including stability and mechanism of insertion , folding and association in lipid bilayers and detergent micelles . Structure and mechanisms of antimicrobial peptides . This is followed using optical spectroscopy in combination with rapid reaction apparatus , protein engineering and mechanistic interpretation of the data . . University professor in Protein Biophysics . Particular emphasis on understanding molecular basis for cytotoxicity of protein aggregates , based on thorough understanding of the forces driving protein association with each other and with membranes . Therapeutic strategies to prevent undesirable associations are of particular interest . As complementary strategy also focus on formation of functional amyloid in bacteria . Specialties : Protein folding kinetics and thermodynamic stability followed by spectroscopic approaches and analyzed using linear free energy relationships . Dynamics of interaction with ligands detergents .. Technologies :",idps;membrane proteins;characterization;engineering;stability
"Senior Scientist II . Fragment based drug discovery . SAR by NMR . . A biophysical chemist that specializes in protein NMR spectroscopy , molecular dynamics , and molecular modeling . Fragment based drug discovery .. Technologies : NMR",small molecules;screening;structure
"Scientist Cryo EM . Cryo EM Structural Biology . A motivated interdisciplinary Scientist in the Department of Structural Biology at Genentech with 20 years of experience . I explore the structural and functional properties of therapeutically relevant proteins and their interactions with diverse ligands through protein expression , biochemistry and CryoEM . I collaborate with scientists throughout Genentech s Research and Development organization to advance both small and large molecule programs and fundamental research with over 25 publications .. Technologies : CryoEM",proteins;small molecules;interaction;structure
Senior Bioinformatics Scientist . . . Technologies :,
"Research Data Analyst . Computational biologist in the Gawad lab , in the Hematology Oncology division of Pediatrics Analyzing , interpreting , and visualizing DNA data to advance precision medicine Building data pipelines in Stanford 's HPC cluster with Perl , Python , R , Bash , and open source software for automated , high throughput analysis of genetic data . . Technologies :",
"Senior Research Associate . Senior Research Associate Novozymes Department : ASAP Assay , Screening Protostabilization ERAD Enzymes Research Automation and Digitalization Automating and digitalizing workflows Cross functional learning cycles between Wild Type , PE and production strains across Enzyme Research Molecular biologic methods , including MTP Cloning , enzymes digesting , PCR , genomic DNA , spore PCR , DNA sequence Nanopore , transformation in E coli and in Bacillus subtilis , Bacillus licheniformis and Aspergillus oryzae Robot and machine learning , primer and cloning design for automation Assays and expression of enzymes Liquid handler ; Tecan , Agilent s BRAVO and laboratory robot Data processing in Jupyter Notebook Python , Excel and JMP Protein engineering and optimizing enzyme variants Cloning and transformation in Aspergillus oryzae Primer and cloning design for automation in Jupyter Notebook HTP assay screening HTP Screening on laboratory robots for enzyme activity and stability in Bacillus subtilis and Aspergillus oryzae Small scall fermentation in MTP Laboratory robots , Momentum and Agilent 's BRAVO Data processing in Jupyter Notebook Python , Excel and JMP . I have strong knowledge , experience and hands on in molecular biology , Protein engineering PE and microbiology including techniques such as qPCR , ddPCR , DNA sequencing NGS , Nanopore , Sanger , cloning , genomic RNA and DNA , assay , purification , gene editing , CRISPR , assay , expression of different enzymes for activity , small scale fermentation and data processing , robot and machine learning , primer and cloning design for automation . I have been working in eukaryotic and prokaryotic organisms Laboratory robots and liquid handlers , such as : Tecan , Agilent 's Bravo , Biomek and Hamilton . Languages Fluent in Danish and English , both in verbal and written .. Technologies :",enzymes;expression;stability
"Vice chair of QSP Special Interest Group . . Dr. Lourdes Cucurull Sanchez leads the Quantitative and Systems Pharmacology strategy in GSK Clinical Development , with the goal to embed QSP into its MIDD framework . During her prior Discovery Research experience , she provided programmes with mechanistic QSP simulations to help them accelerate or gain confidence in their path forward . She has set up mechanisms to develop and promote the QSP discipline within and outside GSK . Elected Vice chair of the ISoP QSP SIG . Founder and active member of the UK QSP Network . Member of the IQ Consortium QSP WG2 , ASCPT and ISoP. Prior to joining GSK , she accrued 8 years of modelling experience at Pfizer , firstly as a Computational Chemist and later on as a QSP modeller . She has influenced decisions concerning a wide range of indications , mechanisms and therapeutic modalities , across the therapeutic areas of oncology , immuno inflammation , respiratory , neurosciences , gastrointestinal and genitourinary . In 2022 she received a GSK Innovation , Performance and Trust IPTc award for her impactful performance . In 2007 she received a Pfizer W.E. Upjohn Award for her outstanding contributions and accomplishments in the area of Innovation . In 2004 , she was appointed as Postdoctoral Research Associate at the University of Cambridge , sponsored by Unilever . She obtained her PhD in Chemistry in 2000 at the Universitat Autonoma de Barcelona . In 1995 she obtained an MPhil in Chemistry at The University of Newcastle upon Tyne , sponsored by The British Council and La Caixa . Specialties : Quantitative Systems Pharmacology , MID3 , Systems Biology , PKPD modelling , Machine Learning , Mathematical Modelling , Modelling and Simulations , In silico ADME , Computational Chemistry , Strategic Thinking , Management , Networking , Influencing , Diversity Inclusion .. Technologies :",
Computational Staff Scientist Engineer . . . Technologies :,
"User Engagement Lead Community Manager . Work at the intersection between research scientists and the KBase development and implementation teams to ensure that KBase can help answer important questions regarding microbes and society . . Making science more efficient by helping to improve microbiome data science through effective communication and collaboration . I work across the science , technology , engineering , and communications space with the goal of accelerating our understanding of microbes in our environment and health . My professional training is in marine science , with a foundation in using ' omics to understand biological interactions , and I am passionate about making science communication and collaboration impactful . . Technologies :",
Ph . D . Projects focussing on structural and biochemical characterization of various families of membrane proteins . . . Technologies :,membrane proteins;characterization;structure
"Researcher . . Mariano studied biology at Universidad de Buenos Aires , Argentina , where he also obtained his PhD in chemical biology with Gonzalo Prat Gay . He was a post doc in the group of Cathy Royer in Montpellier , and a post doc at the Structural Virology , Felix Rey 's lab in Paris , before he started his lab in Buenos Aires . His main interest is currently in the understanding of membrane protein protein interactions using biochemistry , biophysics and high resolution cryo EM structure determination .. Technologies : CryoEM",membrane proteins;interaction;structure
"Senior Scientist , Assoc . Professor . Senior scientist at Therapeutic Immune Design Unit , Dept of Clin . Neuroscience , Karolinska Institutet Assoc professor in molecular immunology . Research profile : Allergen specific immunotherapy , immune regulation in allergy and inflammation , immune regulation in neuroinflammatory disease , vaccine adjuvant development , cancer immunotherapy , clinical trials Research , supervision of students , teaching , scientific writing . Role at present positions : Senior researcher and Assoc . Professor at Karolinska Institutet at Dept . of Clinical Neuroscience , Therapeutic Immune design unit . Research area : Cancer immunotherapy , allergy and multiple sclerosis . Disease mechanisms in terms of regulation of the immune response to allergens autoantigens and inflammation . Cancer immunotherapy development for clinical application . Preparation for clinical Phase I II clinical trial of personalized cell therapy of cancer . CTO at TCER AB , member of management team and of the board . Responsible for cell therapy R D , clinical trial preparation and project coordination . Previous positions : Director of Immunolgy , Viscogel AB . Responsibility for the company 's immunology program focused on vaccine adjuvant development . Chief coordinator of a project within the EU FP7 program research for SMEs under grant agreement no 261954 : ViVac ViscoGel , a chitosan based adjuvant for prophylactic and therapeutic vaccination , coordinated by Viscogel AB 2010 2012 . The project included a clinical phase I IIa clinical trial . Senior scientist and associate professor at Dept of Medicine , Karolinska Institutet . Research on allergens , mechanisms of allergy and asthma and novel strategies for allergy vaccination . Postdoc project : Basic research on membrane protein assembly using molecular biology techniques . PhD in medical biochemistry : PhD thesis title : Isolation and characterization of variant forms of secretin and vasoactive intestinal peptide with special emphasis on their biosynthesis Summary of skills : Methodological : allergy and asthma models in mice , preclinical and clinical research studies . Immunology , cell biology , molecular biology and biochemistry techniques . Project leading ; Research leadership , organisation of scientific meetings and seminars , research funding applications for EU grants and national grants . Research and project presentations , oral and written . Clinical trial experience from a phase I IIa clinical trial at Viscogel AB . Member of the local human ethics committee in Stockholm . Technologies :",
"Graduate Student . Structural Biology RNA Research Lab Graduate Research Assistant , University of Michigan Co mentored by Dr. Amanda Garner and Dr. Melanie Ohi Thesis title : Structure and functional analysis of Human Dicer . Research Interests Cryo Electron Microscopy Structure and function analysis of RNA binding proteins MicroRNA biogenesis RNA structure Data Visualization . Technologies : CryoEM",nucleic acids;proteins;interaction;structure
Bioinformatician . Working on HIV cure strategies in children . . Technologies :,
Science leader in Computational Toxicology . . . Technologies :,
"Head NanoImaging Core Facility . Head of the NanoImaging Core Facility and available as consultant for cryo EM application training , help with picking the right hardware lab setup , help in dealing with companies . Experienced Senior Manager with a demonstrated history of working in the research industry and academia . Skilled in Electron and Light Microscopy in all its facets , Teaching and Education , Research and Development R D , Marketing and Sales , Applications , Chemistry , Materials Science and Soft Matter , Physics , and Life Sciences . Strong professional with a long standing industrial career at FEI Thermofisher and experienced in working with the pharmaceutical industry . Also a significant academic career at the Radboud University Nijmegen , Eindhoven University of Technology , The Dutch Cancer Institut and Institut Pasteur . Strong communicator and presenter with an extensive international network . Deep financial insight in small medium and large sized companies as well as universities and research institutions . Experienced in sales and marketing strategy techniques like Miller Heiman and STRAP procedures . Well accustomed to quarterly targets and deliverables , but also accustomed to longer term academic planning . Able to communicate in 4 languages and available as consultant for trainings , R D , marketing , sales , strategic advice for M A or investments as well as setting up labs and purchasing equipment especially focussed on cryo electron microscopy . . Technologies : CryoEM",structure
"Senior Scientist . . A computational chemist with 6 years of industry experience in drug discovery . One of the inventors for 7 patent applications , and 2 pre clinical candidates . Experienced in hit identification , knowledge based drug design optimization in collaboration with cross functional teams .. Technologies :",
"Lead Scientist . . I work on machine learning research at Booz Allen Hamilton with applications in adversarial defense , privacy , and cyber . I am also involved with biostatistics , genomics , and computational epidemiology research at Stanford and Harvard Universities . Currently I am also pursuing a part time PhD in CS ML at UMBC .. Technologies :",
"Doctoral Researcher . Tanishq joined the Levenson lab in August 2019 : Research on applying deep learning to novel microscopy techniques for enabling digital pathology applications . First author of book chapter in Artificial Intelligence and Deep Learning in Pathology Mentored computer science senior design team 4th yr undergrad students working on lab project Mentored two other undergraduate students working on a variety of lab projects Presented PhD research at ICML2020 Computational Biology workshop , BMES 2020 , SPIE Photonics Europe 2022 One first author journal publication under review One first author journal publication under preparation . Tanishq Abraham is recognized as a child genius and a prodigy . He graduated high school at 10 years old with a 4.0 GPA and at 11 he obtained 3 college Associate Degrees also with a perfect 4.0 GPA . When he was 14 , he finished his biomedical engineering program . He graduated from University of California , Davis with summa cum laude becoming the youngest biomedical engineer . As an undergrad , he has presented papers at several conferences . At 14 , he was the first author on a review paper about smart bio inspired vesicles and it 's biomedical engineering applications published in IOP Physical Biology . Tanishq joined the biomedical engineering PhD program at 15 . By 16 , he became a published book chapter author in the book Artificial Intelligence and Deep Learning in Pathology . Now at 19 , he is a 5th year PhD candidate in biomedical engineering at UC Davis . He has worked for 3 years in the Levenson Lab at UC Davis on applying deep learning to novel microscopy techniques in order to enable digital pathology applications . He has presented his PhD research at various venues , such as the ICML2020 Computational Biology workshop and SPIE Photonics Europe . Tanishq has also reviewed few books that includes two science fiction books and recently a machine learning book . Tanishq is self motivated , curious about the mechanics of things , a passionate learner , goal setter and achieving those goals , a hard worker and an over achiever . He enjoys all things science , technology , politics , movies and sports . Loves to interact and talk with people . Tanishq has appeared on many international and national TV , radio and print news , TV and radio talk shows , realty TV shows and documentary shows . He is a role model for young and old students . Technologies :",
"CNRS Researcher . . My aim is to understand glycosyltransferases and glycan modifying enzymes on a molecular level by combining structural biology approaches with in vitro and in vivo functional analyses . After carrying out a PhD 2013 2016 in the group of Michael Hothorn , first at the Max Planck Institute in T bingen Germany and then at University of Geneva Switzerland , I joined the group of Kaspar Locher at ETH Z rich Switzerland as a postdoctoral fellow to study the yeast oligosaccharyltransferase complex using cryo electron microscopy . In 2019 , I was recruited by the CNRS as Charg de Recherche de Classe Normale and in the following year I obtained the ATIP Avenir grant . I am now leading a small team focusing on the characterization of the heparan sulfate biosynthesis machinery in the SAGAG group at the Institut de Biologie Structurale in Grenoble . . Technologies : CryoEM",enzymes;structure
"Director Bioinformatics and Data Analytics . . Experienced Bioinformatician with a demonstrated history of working in pharmaceuticals industry . Skilled in Life Sciences , NGS data analysis , precision medicine , R and Algorithms . Strong research professional with a PhD focused in Bioinformatics from Technische Universit t Dresden . . Technologies :",
"CNRS researcher DR2 , Deputy Director of CiTCoM , Team leader Membrane transport signaling . bacterial resistance to antibiotics RND efflux transporters , regulators , b lactamases , porines Integrated structural biology : crystallography , cryo EM , SAXS Biophysical analyses of bio molecules interactions . Expertise : structural biology of membrane proteins MP and of large assembly complexes using crystallography ; production and crystallization of MPs extracted from either membrane of gram negative bacteria ; development of crystallization tools specific to MPs sponge phase ; model of protein actors in antibiotic resistance ; structure function analysis of eukaryotic bitopic receptors ProlactinR , VEGFR The projects of my team focus on tripartite efflux pumps from Pseudomonas aeruginosa implicated in antibiotic resistance . Our recent work , linking in cellulo MIC measurements , crystallography and cryo electron microscopy , brought important information for the comprehension of the assembly mechanism of these pumps . Technologies : CryoEM",membrane proteins;interaction;structure
Post Doc at Purdue University . . My interests are : Macromolecular structure and dynamics . Multi protein complexes and conformational changes . Virus Antibody structures and structural virology . Viral conformational changes . Transmembrane singling . Cryo Electron Microscopy and tomography . . Technologies : CryoEM,proteins;structure
"Group Leader Screening Sciences . . My current focus are enabling innovative drug discovery technologies and novel drug modalities in the interface of chemistry and biology . We are scouting , evaluating and deploying emerging methods and technologies to identify novel first in class drug mechanisms and prototypes . Besides a number of innovative drug discovery approaches our focus is on two encoded library technologies : DNA encoded chemical libraries DEL and ribosomal in vitro display of cyclic peptide libraries containing non natural amino acids Peptide Discovery . Our group uses both technologies to identify novel starting points in pharmaceutical drug discovery projects . Since 2000 , I am involved in early stage pharmaceutical drug discovery research at the Novartis Institutes for Biomedical Research . I started as Labhead in the Lead Finding Platform with responsibility for the development , and realization of highly miniaturized and automated high throughput hit finding projects to identify new drug candidates . From 2007 to 2012 , I was leading the Label Free Technologies group in the Center for Proteomic Chemistry . 2012 I had the opportunity to build and lead the Screening Sciences Group . Since 2018 , I am the Basel lead of our Chemical Genetics group within the Chemical Biology Therapeutics . I received my Ph . D. in Bioorganic Chemistry at the Max Planck Institute of Biochemistry in Martinsried in 1999 and studied Chemistry at the Ludwig Maximilians Universitaet in Munich , Germany . From 1999 to 2000 , I worked as a post doctorate in the Combinatorial Chemistry department at Novartis Research on the multiparallel combinatorial synthesis of radio tag encoded chemical libraries . . Technologies :",peptides;small molecules;screening
Scientific Researcher . Researcher working with electron cryo microscopy Cryo EM at Stockholm University studying the evolution of the mitochondrial ribosome . . . Technologies : CryoEM,structure
"Bioinformatics Scientist . . As a member of DRAGEN structural variant team at Illumina , I work on developing , implementing , and benchmarking statistical and machine learning methods together with a focus on algorithms and high performance computing to provide accurate and feasible analysis of NGS data .. Technologies :",
"Release and Stability coordinator senior associate scientist . planning and coordinating all QC activities deliverables related to product release according to feasible project timelines lead times , including label pack samples and start stability studies . The Quality Control Development QCD labs group is part of the Analytical Development AD Department of the Vaccines Process and Analytical Development VPAD sector . It consists of 6 sub teams Raw Materials , Sample Management , Cell Culture , Microbiology , Release Stability and Data Systems and is responsible for release and stability R S testing as well as the corresponding reporting of Janssen s virus and antibody products for use in clinical trials and the analytical support of the pilot plant activities . . . Technologies :",antibodies;developing;quality;stability
"Undergraduate Researcher . Working on analyzing metabolomics and metagenomics data to bring out insights on the relationship of microbiomes and human health . . Harvey Mudd graduate and computational biologist in training . Interested in using machine learning , statistical , and probabilistic approach to tackle problems in multi omics , microbial ecology , and cancer genomics . Here 's my Google Scholar page : https : scholar.google.com citations view op list works hl en hl en user djX0gYMAAAAJ . Technologies :",
"Lead Biologist Project Manager . Project manager of the TEAD inhibitor program in licensed in May 2021 . Lead multiple small molecule drug discovery programs from initial project review to LO together with the Med Chem team in different therapeutic areas oncology , MS , HD . Identify , design perform innovative drug screening technologies to determine compounds activity : full screening cascade , target engagement , PK PD translation elucidation MoA. Management of all world wide CRO based activities , from optimal CRO identification , contracting , to weekly team meetings . Oversee all internal lab based activities in support of the projects on a day to day basis . Manage follow up scientific non scientific aspects of projects : patent literature , grant reports , timelines , publications budgeting . Develop broad knowledge of the competitive intelligence horizon for each project . Report on progress of projects to internal teams , management , licensing opportunities , scientific advisory board partners involved . I am a creative , autonomous and proactive project leader with over 8 years of experience in biotech leading multiple drug discovery projects from initiation to Lead Optimization and in licensing . I have learned to work with great detail , under high pressure and under tight deadlines , and this while keeping my enthusiastic attitude . I have proven that I can adapt to very diverse fields of expertise . . Technologies :",small molecules;interaction;screening
"Senior Scientist . HTS biology discovery . Protein Biochemist Biophysicist with 5 years experience in Biotech and drug discovery Accomplished , multifaceted and energetic Ph.D. scientist with demonstrated hands on experience implementing protein biochemistry and biophysical methodologies to study difficult protein targets . Demonstrated success in developing and implementing novel biophysical methodologies for drug discovery Versatile and adaptable biophysicist implementing various techniques to assays hard to drug targets Goal oriented , organized leader conceiving , designing and executing projects Areas of Expertise : Drug discovery HTS screening Hit to lead assay development Soluble and Membrane Protein Expression and Purification Protein Quality Control Analysis PAGE , SEC , chromatography , CD , dynamic static Light Scattering , Mass Spec . , Chemical Cross linking , Thermal DenaturationAssays , DSF Protein engineering and construct rational design Protein labeling and conjugation Small Molecules substrates , inhibitors , ligands binding and mechanism of action Membrane protein crystallography specialty lipids , bicelles , LCP Effective communication skills Efficient Project and time Management to meet goals on marked time frames Innovation Team leadership Creative problem solving Collaborative and Synergistic across various disciplines . Technologies : SLS DLS;DSF",membrane proteins;proteins;small molecules;expression;quality;screening;stability
"Lead Scientist , Respiratory R D . Lead , manage , plan , and monitor all aspects of formulation R D activities from early feasibility to commercial manufacture . Plan and develop novel initiatives to produce successful formulations for drug device combination products . Work as a member of cross functional pharmaceutical project teams providing technical support across a range of processes and equipment trains and troubleshoot any associated development issues . Evaluate , manage , and lead interactions with third parties to achieve project goals . . Provide Technical leadership to other team members . Deliver high levels of customer service both internal external . . Expertise : Oral Solids Nanopharmaceuticals NDA ANDA Paediatric Inhalation Drug Development . Experienced pharmaceutical scientist with more than 9 years of experience in all aspects of NDA and ANDA product development including oral solids , liquids , nanoparticles , lipid based formulations , novel paediatric platforms and scale up through launch for regulated markets . Strong educational credentials including a PhD in Pharmaceutics . Skilled in designing experiments to support product development within a team based environment ; interacting with customers to address product development needs and tailor formulations accordingly . Demonstrated expertise in managing direct reports and also mentoring and sharing knowledge with colleagues at all levels . Exceptional ability to concurrently manage several projects from R D scale to commercial production , while at the same time meeting aggressive timelines . Research expertise also includes the development of novel drug delivery systems , such as nanoparticles , liposomes , proliposomes , and controlled modified release systems . Expertise in addressing solubility and bioavailability related challenges as well as performing in vivo mapping of formulations . Excellent interpersonal and communication skills with the experience required to remain highly focused and exceptionally productive in a fast paced , high pressure environment . Highly flexible individual ability to switch seamlessly from one project to another when priorities change . . Technologies :",formulation
"Senior Scientist . . Experienced Researcher with a demonstrated history of interdisciplinary collaborations within the biotechnology industry . Expertise in Protein Chemistry , Structural Biology , Biophysics , Membrane Proteins , Protein Lipid Interactions , Enzyme Kinetics , RNA Biochemistry , and Protein Purification . . Technologies :",membrane proteins;nucleic acids;proteins;characterization;interaction;structure
"Senior Scientist Bioanalytics . . Studied Biochemical engineering and researched membrane protein biophysics with a keen interest in process , product , and analytics development . Bringing broad range of knowledge to specialized Outside in problem solving .. Technologies :",membrane proteins;characterization
"Sr . Scientist Data Architecture . At Capsida Biotherapeutics , Scott is building and delivering solutions with innovative pipelines and scientific workflows across the organization from basic research to process and analytics development . This data science team is leading the adoption and growth of cutting edge computational biology and engineering tools in the context of an exciting gene therapy biotech start up . . I started my career as a bench scientist in a molecular biology lab at the Salk Institute for five years . I was always drawn to software based tools and how well they enabled and enhanced many aspects of science . Following that interest , I acquired a Master degree in computer science before joining Amgen in 1998 where I was able to merge the two disciplines software and computation to support and facilitate cutting edge scientific research . At Amgen , I worked as a software developer , lead programmer , business analyst , product owner , project manager , technical lead , systems architect , cloud architect , and client facing lead for numerous areas and projects in Research Informatics .. Technologies :",
Graduate Research Assistant . Method 1 : Development of antibody conjugated affinity based TEM grid which can selectively capture tau filament from Alzheimer type neurodegenerative diseases and prion disease patient brain tissue for structure determination . My current two high potential projects involves High Resolution Three Dimensional Structure Determination of Helical Filament from three human neurodegenerative patient 's brain using Cryo EM : a Tau Filaments from Two Prion Diseases GSS and PrP CAA Adopt Same Folding as Alzheimer s Disease Manuscript under review b Cryo EM structure determination of Tau filament from frontotemporal Dementia Patient Brain Work in progress c Purifying Human Tau Filament from Different variant of Frontotemporal Dementia patient 's Brain for structural analysis using Cryo EM Structure Analysis On going Method 2 : Development of Inhibitor Modified TEM Grid Fabrication Technique for Rare Human Protein Purification in Single Step for Cryo EM Analysis . 3.6 Angstrom Resolution Structure of Target Protein Achieved Accepted in ACS Nano . Method 3 : Development Polymer Based Materials for Concentrating Pure Engineered and Non engineered Biomolecules on TEM Grid Surface for Cryo EM Analysis Manuscript in preparation . Method 4 : A pseudovirus nanoparticle vaccine targeting the receptor binding HA1 domains of influenza viruses : This work has developed S60 HA1 pseudovirus nanoparticles into an effective flu vaccine targeting the receptor binding domains of influenza viruses Manuscript Under Review in ACS Nano . Structural Biology Cryo EM Membrane Protein Human Prion Diseases Human Neurodegenerative Diseases Prion protein amyloidoses Frontotemporal Dementia Gerstmann Str ussler Sheinker GSS Prion Protein cerebral amyloid angiopathy PrP CAA Tau Filament Organic Synthesis Google Scholar : https : rb.gy k2fviq . Technologies : CryoEM,antibodies;idps;structure
Senior Scientist . . Specialties : Cryo electron tomography . Technologies : CryoEM,
"Scientist . . Ph.D. specializing in microscopy , genomics and computer vision . Proven expertise in developing computer vision algorithms for quantitative inference of biological processes such as cancer progression and stem cell engineering .. Technologies :",
"Research Scientist . . Specialties : X ray crystallography , Membrane proteins , Protein biochemistry , Construct design , Protein expression , Protein purification and Crystallization . Technologies : Xray",membrane proteins;expression;structure
Principal Scientist I Bioinformatics . . Working on algorithm development of modules in oncology pipelines . . Technologies :,
"Doktorand . Ribosome targeting antibiotics and antibiotic resistance mechanisms , translational stalling and regulation of translation . Biochemistry , molecular biology and structural biology Cryo electron microscopy . Supervisor : Prof. Dr. Daniel N. Wilson . . . Technologies : CryoEM",proteins;interaction;structure
"PHD Candidate . Neurovascular Interface group . Fast track student . International Max Planck Research School for Neural Circuits . Currently employing single cell and spatial transcriptomics approaches to study vascular diversity in CNS development . Managing high resolution cryo electron microscopy projects to visualize native endothelial cell structures . . PhD student specialized in brain and vascular biology . Experienced in establishing novel experimental , microscopy imaging and analysis pipelines for solving biological questions . My interests align with strategizing complex projects for scientific discovery and technological development . I enjoy presenting my results using story telling and data visualization tools and it is my favorite part of the PhD experience .. Technologies : CryoEM",
Visiting Scientist . . . Technologies :,
"Associate Director of AMRF Functional Genomics Common Research Resource . . I am running a bioinformatic core for Adelson Medical Research Foundation where we have a large number of world class collaborators inside and outside of UCLA . I have extensive experience in both wet lab and computational biology . I am an author of 50 peer reviewed publications and have an expertise in the following fields : Single cell bulk RNAseq ATACseq , DNA microarray , Methylation Seq , miRNAseq , ChIPseq , Proteomics , Membrane Protein Biochemistry , Liquid Chromatography Mass Spectrometry , Bioinformatics , Database Management , Retinol Physiology , Angiogenesis , Cancer Biology and Neuroscience . I am enjoying computational analysis of large datasets in genomics and proteomics , but I also enjoy communicating with my client daily basis and listen to their requests and provide better experimental designs , insights in biology and analysis methods , ultimately lead to high profile journal publications . I also maintain public website for Bioinformatic tools and tutorials . Please visit : https : trello.com b 3g0Twoa7 bioinformatics training resources geschwind lab . Technologies :",
"Research Assistant . . 8 years of professional experience in Life Sciences panning diverse streams like Pharmaceuticals , Nutraceuticals , Biologics , Diagnostics . Hands on experience in PROTAC PROteolysis TArgeting Chimera Assays Classical Drug Discovery Electrophysiology Manual Automated Patch Clamp Assay Design Development Cell Based Assays Ion Channels , GPCRs , Calcium and Thallium Flux assays Toxicity Profiling hERG Kv 11.1 Channel inhibitors Screening Activity Screens EC50 IC50 Determination Multipelxing Flow Cytometry and Magnetic bead based Multi analyte determination Immunophenotyping Determination of various cell populations Physiologically Relevant in vitro model Development , Primary Culture DRG neurons , Splenocytes and Lymphoctes Isolation , PBMC Cultures Stable cell line generation Single cell cloning Biochemical Assays ELISA , TR FRET , Absorbance based Assays Affinity Assays Radioactive Ligand Binding in vitro Permeability Assays Determination of Gastric permeability , Bioaccessibility , Blood Brain Barrier permeabilty Activity profiling of Nutraceuticals PDCAAS Scoring SOFT SKILLS Technical Write up , Technology Transfer , Proposal writing , Troubleshooting , Report generation . Client Communication , Client Management . Technologies : FRET",molecular glues;small molecules;developing;screening
"Scientist II . . An innovative scientist with extensive experience in in vitro cell biology to help drive target validation for novel drug biotherapeutic development programs , including fifteen years of gene delivery protein expression large scale cell culture in Sf9 insect cells , HEK 293 CHO primarily of GPCRs , stem cell research , assay development and optimization of novel technologies from fast paced biotech pharmaceutical setting to rigorous and regulated chemical industry standards Most recently , two years in academic research overseeing a young and vibrant genetics lab s daily operation supporting graduate and postdoctoral projects while maintaining an independent scholastic endeavor , plus two years in Cellular and Molecular Toxicology for one of the leading chemical companies developing , validating and implementing in vitro cell based assays to determine cellular and molecular mechanism of toxic action utilizing primary cells and established cell lines via flow cytometry , qRT PCR gene expression studies , luminescence , fluorescence , and absorbance based reporter technologies within a GLP laboratory setting A seasoned flow cytometrist , certified operator of Beckman Coulter flow cytometers Epics XL MCL , Gallios utilizing Expo 32 ADC software as well as Becton Dickinson flow cytometers FACSAria II SORP sorter utilizing FACSDiva software , FACScan , Guava An empathetic team leader and a resourceful team player with excellent interpersonal skills and the passion to pursue excellence in the workplace . Technologies :",
Doctoral Student . AG Becker Supervisor : Prof. Becker . Doctoral Student at the Institute for Virology of the Philipp University of Marburg 1 . Studies on homo oligomerization of Ebola Virus VP30 and development of an interaction inhibitor 2 . Development of targeted Protein degradation via PROTACs as antiviral therapy against Ebola Virus and SARS CoV 2 . 3 . Studies on Rab1 dependent intracellular trafficking of SARS CoV 2 spike protein . Technologies :,molecular glues;proteins;small molecules;interaction
Bioinformatics Scientist II . . . Technologies :,
Bioinformatics Research Scientist . . . Technologies :,
Director Of Bioinformatics . . . Technologies :,