text_p,labels
"3D EM Facility Manager . . As a Facility Manager at Karolinska Instituet 's 3D EM facility , I manage the multi user facility , train new users , and support data collection on the negative stain and cryo transmission electron microscopes TEMs and cryo FIB SEM . The 3D EM facility currently houses a Thermo Fisher Scientific Titan Krios 300 kV , a Talos 120 kV , Aquilos2 FIB SEM , and Leica sp8 cryo confocal microscope . This new facility , built in 2019 2020 , has been built specifically for high end biomedical electron microscopy . Using my previous training as a Cryo EM Research Specialist and a material science microscopist , I bring my expertise of the equipment and analysis methods to KI to enable a much broader group of KI researchers to utilize the enormous recent advances in electron microscopy technology .. Technologies : CryoEM",structure
"Senior Research Scientist . Research Specialist in Structural Virology with Ass . Prof. Pavel Plevka . Structure determination of human pathogenic picornaviruses and ecologically important marine viruses of bloom forming microalgae , employing state of the art cryo electron microscopy . Co Supervision of PhD student . . Detail oriented , responsible and committed research scientist working to better understand the architecture of microscopic organisms and how they succeed in the host environment . My expertise includes data analysis and interpretation and more than a decade of experience in structural biology using a variety of technologies in protein structure determination including cryo electron microscopy . Specific fields of interest that I would like to develop further include data analytics and phycology green algae biotech . I am well organized , comfortable working independently , with a spirit to extend my research enthusiasm to enjoy a pleasant workplace atmosphere .. Technologies : CryoEM",proteins;structure
"Senior Scientist Medicinal Chemistry . Project Team Lead . Drug discovery , medicinal chemistry , DNA encoded libraries , synthetic organic chemistry , total synthesis , diversity oriented synthesis , chemical biology , molecular glue degraders . Technologies : Xray;CD;FP",molecular glues;small molecules;screening
"Senior Research Scientist . . Experienced Scientist with a demonstrated history of working in the pharmaceuticals industry . Skilled in High Content Screening , Image Analysis , Flow Cytometry , Assay Development and Validation , Genomic and Small Molecule screening and Laboratory Automation . Strong research professional with a Bachelor of Science BS focused in Medical Technology from Kutztown University of Pennsylvania .. Technologies :",small molecules;screening
"PhD . Performed imaging via advanced microscope techniques and image processing . Reconstructed 3D structure via MATLAB programming Analyzed experimental data , e.g. MATLAB , IDL Setup Microfluidic devices Conducted emulsion preparation and stability evaluation . Multi cultural and reliable researcher with 7 years of international study and research experience in biophysics and biomaterials in Germany . Proficient in imaging , image analysis , data evaluation , surface functionalization and Microfluidic devices . Good problem solver and fast learner when faced nontrivial problems . . Technologies :",
"Principal Scientist . Assignments within early drug discovery , developing peptide drugs and combination therapies for metabolic diseases . Maturing of internal projects to enable partnership and joint development of drug candidates with pharma , e.g. the Bayer Gubra collaboration on novel peptide therapies . Also , having assignments in Guba s core CRO business delivering high quality in vitro data to costumers . Employed in the Molecular Pharmacology Assay Group , having strong focus on functional cell based in vitro assays to drive SAR efforts for development of novel peptide ligands for GPCR receptor targets . Also , responsible for conducting bioanalysis of bio chemicals in tissue and plasma samples . . A pharmacist by education , I am an experienced specialist in the area of in vitro research in the pharma industry . I am very knowledgeable in every aspect of early drug discovery . Besides a strong focus on my specialist role , I have also gained rewarding people management skills through my team leader responsibilities for a compound management unit and project manager responsibilities for early drug discovery projects . With a passion for innovation , I greatly appreciate being part of evaluating new ideas , including being the idea originator . Ideas ranging from new targets , assay technologies to optimization of equipment and processes . Working as a senior research scientist in the pharma industry I have : 1 Deep experience in all aspects of biochemical and cell based in vitro assays targeting G protein coupled receptors 20 GPCR s , ligand gated ion channels and enzymes 2 Strong skills in implementing and optimizing automated pipetting assay platforms 3 Always strived for implementing new technologies and continuously optimizing processes 4 A significant track record of successful CRO interactions with experience from the customer as well as from the CRO service provider side . Productive coordination of experiments performed across departments as well as in a global setting . My experience with assays on disease relevant tissue and my biological understanding of underlying disease mechanisms is anchored within the CNS and metabolic therapeutic areas . Specialties : drug discovery , CRO , in vitro assay development , Automation , pipetting robots , liquid handling , people management skills , project leader ship , target maturation , small molecule libraries .. Technologies :",membrane proteins;peptides;developing
Scientist . . Experienced Researcher working in the intersection of health care and computing sciences . Technologies :,
"Armchair archaeologist , genealogist part time sheep farmer . . As of 15 Sept 2015 , I have retired . While working at Novartis Direct hands on contribution to drug discovery research in the fields of computational science , including : bioinformatics , computational biology , computational chemistry , CADD computer assisted drug discovery and cheminformatics . Influence on the selection and assessment of novel Oncology targets target classes . Full name : Charles Gregory Paris ; bibliographic name : C. Gregory Paris ; possible misspellings : Parris , Parish .. Technologies :",
"Principal Scientist . . Creating and characterizing therapeutics and vaccines against SARS CoV 2 . Ph.D. completed December 2019 in the Veesler lab at the University of Washington : Understanding coronavirus fusion through structure using cryo EM , biochemistry , and bio physics to learn about coronavirus spike proteins .. Technologies : CryoEM",biologics;proteins;characterization;structure
"Head of Biophysics Part time . Leading a biophysics approach to aid the development of the next generation of lipid nanoparticle LNP nanomedicines . . I have over 10 years of experience engineering and characterising lipid systems . I am a specialist in lipid membrane biophysics with a focus on coupling fundamental lipid structure and phase behaviour with cellular signalling and dynamics to approach disease pathways from a lipid perspective . My research spans the physical life sciences interface and I have extensive experience collaborating across disciplines , with industry partners and internationally . This includes project management for specialist synchrotron facility experiments SAXS SANS .. Technologies :",carriers;developing;engineering
"Graduate Research Assistant . Chris Ackerson Research Group . Currently working towards completing my PhD in Analytical Chemistry from Colorado State University . My research focuses around developing clonable contrast tools for electron microscopy . After gaining experience with transmission electron microscopy and scanning transmission electron microscopy of resin embedded sections prepared via ultramicrotomy , I am integrating our clonable contrast tools in cryo electron microscopy techniques . Through a collaboration with the CU Boulder Center for Cryo Electron Tomography , we are working to produce electron cryo tomographic reconstructions of FIB SEM prepared lamellae for our clonable contrast tools .. Technologies : CryoEM",
Computational Biologist . I am working on applying deep learning methods to estimate gene gene interaction in human tissues . This is a UKRI funded research fellowship at the Earlham Institute in collaboration with the Alan Turing Institute . . . Technologies :,
"Scientist II . I study the structure and dynamics of biological macromolecules using a variety of experimental tools , including time resolved serial femtosecond crystallography at the Linac Coherent Light Source LCLS . I support user experiments at the Coherent X ray Imaging CXI and Macromolecular Femtosecond Crystallography MFX beam lines of the LCLS and pursue my own scientific interests . . I am a biophysical chemist working to solve complex problems at the molecular scale that require an interdisciplinary approach and strong physical perspective . I have extensive experience in the fabrication and use of model membranes , including vesicles , supported lipid bilayers , monolayers , and nanotubes . I also have extensive experience analyzing soft materials and biological systems with cryo EM , imaging mass spectrometry , fluorescence microscopy , the Langmuir Blodgett trough , spectroscopic techniques , light scattering , mass spectrometry , and calorimetry . . Technologies : Xray;CryoEM;SLS DLS",structure
"Scientist , Modeling Simulation , Preclinical Translational PK PD . . . Technologies :",
"Senior Scientist . Role : Manager within the Bioassay and Impurities team Drug Development of Biologics . Key responsibilities : Line management a team of 2 3 full time employees and industrial co supervisor of 2 University of Cambridge PhD students , Plans and supervises execution of fit for purpose cell based and protein binding immunoassays to enable developability assessment , lot release and characterization testing , stability studies , formulation development and comparability studies , Represents the bioassay team on CMC chemical , manufacturing and controls teams for gene therapy projects modalities : DNA , mRNA , AAV as well as for monoclonal antibodies , Drafts and executes technological transfer of developed assays to the GMP team and assay qualification , Acts as an Analytical Rep on CMC team for a monoclonal antibody project , Supervises cell line engineering and cell line characterization activities for cell based potency assays assay ready cell banks , receptor expression levels and ligand binding assays , Plans and executes bioassay strategy for AAV based therapeutics release and characterisation testing for biological activity , content assays genome titre , capsid titre , infectious titre etc . , Co developed a potency assay measuring biological activity of AZD1222 Oxford AstraZeneca COVID 19 vaccine . . . Technologies :",antibodies;biologics;nucleic acids;proteins;formulation;interaction;stability
Research Fellow . BovReg Identification of functionally active genomic features relevant to phenotypic diversity and plasticity in cattle . . . Technologies :,
"Postdoctoral Research Fellow . . Driven , analytical scientist with more than 7 years experience in biochemistry , biophysical assay development , X ray crystallography and cryo electron microscopy . Excellent track record in the implementation of challenging projects focused on the structure function relationships of target proteins with antibodies , nanobodies or small molecule therapeutics . Professional partners appreciate my well structured presentation skills and ability to effectively communicate complex concepts to diverse audiences . I am highly motivated to pursue a career in industry , in particular structure guided drug development , where my skills and expertise can be applied to projects that benefit human health .. Technologies : Xray;CryoEM",antibodies;proteins;small molecules;structure
"Bioinformatics Scientist . Develop and validate bioinformatics pipelines for variant detection Analyze and interpret NGS data from various platforms and report results to the R D team Bioinformatics analysis for Assay development . 2 years of biotech industry experience : bioinformatics pipeline development using R Python programming 5 years of experience in bioinformatics research : solid understanding of various sequencing platforms , statistical modeling , and machine learning techniques . Hands on experience in analyzing both microarray and next generation sequencing NGS data 4 years of graduate and undergraduate level teaching experience in computer science Experience working as a software engineer : strong problem solving and programming skills . Technologies :",
"Postdoctoral Researcher . . PhD in Structural Biology . I am looking forward for opportunities in broader areas related to membrane protein biology , cellular mechanisms related to various diseases and challenges in protein biology where I can apply Protein Biochemistry and Structural Biology techniques to contribute to advanced research and also enhance my knowledge in the emerging field of Structural and molecular biology .. Technologies :",membrane proteins;proteins;structure
"Principal Scientist , Computational Biology . Deep learning in cancer genomics . . Technologies :",
"Senior Artificial Intelligence Scientist . . I 'm an AI Scientist with cross domain training in Machine Learning and Bioinformatics . I love to work in the cutting edge of deep learning to design and apply powerful architectures to solve real world problems in different domains . I have extensive experience 8 years in modeling and analysis of large and complex genomics datasets using advanced machine learning and statistical learning methods to find biological insights and patterns . I 'm passionate about contributing to open science , engaging in highly collaborative research , and tackling challenging problem . I am team oriented with the ability to design and execute multiple large scale data science projects independently .. Technologies :",
"Sr . Scientist , New Antibody Products . . I m a Sr . Scientist at the New Antibody Products Research department at Genmab , generating transformative antibody products to fill Genmab product pipeline with novel clinical product candidates by generating in vitro and in vivo proof of concept data , early in the preclinical process . . Technologies :",antibodies;developing;engineering
"Ing nieur de recherche en cryo microscopie lectronique . . My name is Armel Bezault and I have a master 's degree in chemistry and physical chemistry of materials CPCM . I 'm a facility manager of the cryo electron microcopy platform at Institut Europ en de Chimie et Biologie IECB and an engineer in cryo electron microscopy cryo EM . Budgeting , planning , realization of bills and the cerification of the lab according to ISO9001 and NFX 50 900 standard If you want to contact me , my email is : armelbezault at hotmail.com . Technologies : CryoEM",
Computational Biologist . . I 'm an Electrical Engineering Ph.D. candidate at UC San Diego . My research focus is on bioinformatics and population genetics . I have developed methods for genotyping and processing short tandem repeats using short read sequencing data GangSTR and TRTools .. Technologies :,
"Senior Scientist . . Experienced and highly motivated life science researcher scientist with a background in molecular and cellular biology studying protein stability and degradation in relation to aging and neurodegenerative disease . Highly experienced in assay development , including a large range of both cell based and in vitro assays , knowledgeable in the construction of reporter cell lines using a variety of cloning and genetic manipulation techniques , including CRISPR Cas9 . I finished my doctoral studies in the end of 2015 , obtaining a PhD in biology at the Faculty of Science of University of Gothenburg , Sweden . I did my doctoral studies in the lab of Professor Thomas Nystr m at the department of Chemistry and Molecular Biology , studying cellular aging and protein quality control in the unicellular yeast Saccharomyces cerevisiae . In 2017 I started as a post doc researcher in Professor David Rubinsztein 's lab at Cambridge University , funded by fellowships from EMBO and the Swedish Research council VR . In my postdoctoral research project I studied the regulation of autophagy , and the involvement of this process in neurodegeneration and cancer , working with mammalian cell culture and combining conventional techniques in biochemistry and cell biology with modern high throughput methods of CRISPR Cas9 screening and next generation sequencing . Since 2020 I am working as a senior scientist at the department of Discovery Sciences at AstraZeneca , where I am part of the Cell Assay development team , working in a cross functional role to optimize and deliver assays to projects in AstraZenecas research areas in R I , CVRM and oncology .. Technologies :",biologics;idps;proteins;developing;stability
PHD Student . Investigating autophagy and virus replication using cryo ET and cryo EM . . Technologies : CryoEM,proteins;structure
Postdoctoral Researcher . Structural study of anti feeding prophage Afp using high resolution cryo EM . . Technologies : CryoEM,proteins;structure
Principal Scientist . . IEEE Senior Member . Technologies :,
"Scientific Assistant . PhD student in Medicinal Chemistry in the group of Prof. Dr. Karl Heinz Altmann , Institute of Pharmaceutical Sciences IPW . Synthesis and characterization of small molecules towards the development of novel LAT1 ligands as potential antitumor agents . Teaching assistant for the microscopy and laboratory course in pharmaceutical biology . Supervision of Master students during their thesis or project . The project is funded by the NCCR TransCure , an interdisciplinary research network with a focus on membrane transporter and ion channel research . . . Technologies :",small molecules;developing
"Senior Bioinformatics Scientist II . . Experienced Data Scientist Bioinformatician with a demonstrated history of working in the biotechnology industry . Skilled in Machine Learning , Statistical Modeling , and using Computational tools such as R , Python , and Matlab . Working as a player coach , managing teams , and projects , and providing mentorship while being hands on with technical details Strong engineering professional with a Master 's Degree focused in Statistics from the University of Southern California .. Technologies :",
"PhD Candidate Researcher , Baekeland mandate scholar . PhD Candidate Researcher at VIB VUB Center for Structural Biology , Jan Steyaert 's lab . . Project title : Megabody assisted Structure Based Drug Discovery for G protein coupled receptors . This project runs in collaboration with spin off company Confo Therapeutics . Enthusiastic molecular biologist and protein biochemist . Main interests include G protein coupled receptor structural biology and pharmacology , as well as the development of new strategies for difficult to express eukaryotic membrane proteins .. Technologies :",membrane proteins;proteins;structure
"Postdoctoral Researcher . . Current professional focus : antibody based therapeutics synthetic nanobodies , protein engineering , and developing new LC MS techniques for pharmacokinetics pharmacodynamics of antibody drug candidates . 14 years of experience in protein biochemistry structural biology . PhD thesis was focused on membrane protein structure function . I also enjoy writing about science , giving presentations , and telling stories .. Technologies :",antibodies;proteins;engineering;structure
"Principal Consultant Scientist CEO . Established a cGMP , FDA registered product releasing Lab from scratch . 2012 to Current Business Development : Owner , Director Developer of FDA registered audited cGMP analytical and R D Lab , Chief Scientist Syenz Lab , LLC www.syenzlab.co Developed formulations , analytical methods for release assay , and stability indication for six API molecules 5 herbs 10 in actives formulations . Developed and executed Accelerated , Intermediate , and RT stability programs . Validated Process and Lab Equipment including Waters HPLC Dual Wavelength , photodiode Systems , HP s GC Systems , Light Stress Stability and Heat Stability Chambers , then validated Analytical Methods using these systems Validation Protocols writing , Master validation Program writing , cGMP SOPs , Company s Quality Manual writing , Training Programs , Change and document control program writing , Annual reviews , approval , and execution at Lab Monographs development , review , and approvals for API and other inactives used in Contract Manufacturing of the company s products at FDA Registered CMOs . Audited third party manufacturing and Raw Material Labs . Developed of Quality Agreements . Novel formulations and methods with 3 USPTO awarded patents , 1UK IP , 1each Canadian , and Australian IPs Capable of doing 503 B compounding Sterile and non sterile CAPA writing , implementing cGMP in a FDA registered Analytical lab as ASQ s cGMP knowledgeable Professional Owner President of Herbiomed , LLC , FDA registered OTC Patented marketed Product Line www.herbiomeds.com MY STRENGTHS Pharmacovigilance Toxicology , Immunology , therapeutics , Delivery of peptides Hydrophilic drugs , Cell culture , drug cell interaction , Bio assay Liposomes and cochleation NIH Research proposal and experiment protocols PK modeling and simulation Bioassay , DOE , Factorial designs , Latin Square , Random cross over statistical clinical protocol designs and analysis . ASQ cGMP qualified and implementation of the cGMP and ICH guidelines . . OBJECTIVE Integration of Pharmaceutics with Engineering Sciences in my academic profile and career has equipped me with unique knowledge and skills to continue handling challenges of drug development , process engineering , Quality by design , validation , and regulatory compliance . Specialties : Delivery of peptides Hydrophilic drug Cell culture , drug cell interaction , Nano Particles Liposomes and cochleation NIH Research proposal and experiment protocols PK modeling and simulation Formulation using Calorimetry and DOE Process Engineering and Validation Hands on experience with granulators Glatt , Vector , tablet compressors , encapsulator , coaters , and analytical equipment including HPLC spectrophotometer , particle sizer , Freeze fracture , SEM , TEM , DSC .. Technologies : DSC",carriers;developing;formulation;quality;stability
"Associate Scientist . . Highly motivated scientist studying cell molecular machines and host pathogen interactions by X ray crystallography , cryo electron microscopy and cryo electron tomography .. Technologies : Xray;CryoEM",proteins;interaction;structure
"Associate Principal Scientist . . Experienced Cell and Molecular Biologist with a solid background in academic research Ph . D and pharmaceutical industry . Skilled in protein and genetic engineering , assay development and high content screening in the drug discovery space . I work broadly with bacteria , yeast and mammalian cells to engineer pathways or proteins suitable as biosensors in therapeutic applications . I am motivated by making a difference to people s lives by driving progress through collaborations and technological and scientific advances . At Astrazeneca , I currently lead a synthetic biology project which involves building G protein coupled receptor GPCR variant libraries for directed evolution projects . In this role , I am also setting up an automated pipeline for DNA fragment assembly to facilitate protein expression , purification and generation of protein variants to support the gene to structure workflow in drug discovery . I believe that the greatest accomplishments are not reached alone or by competition , but from collaboration and realizing ones network . I have established internal and external collaborations with both academic institutions and biotech companies , e.g. Imperial College and TWIST Bioscience . Parts of the latter collaboration was recently published in ACS Synthetic Biology . Overall , my research has generated six peer reviewed three first author , published papers and three manuscripts due for submission or submitted . In my spare time I like to go on various adventures with my family wife and two kids such as hiking , swimming in the ocean , crab fishing or going to the local theme park . On occasion , I enjoy : winetasting attend and or organize , travelling particularly in wine regions , golf and any kind of winter sport . . Technologies :",membrane proteins;engineering
"Director , Bioinformatics and Computational Biology . Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together . . Trained as a PhD statistician , computer scientist , and genome researcher , I use my quantitative and computing skills to improve lives and human health .. Technologies :",
"Scientific Group Leader , MicroED . . My formal training is in X ray crystallography Scripps Research Institute and single particle CryoEM Salk Institute applied to the structural and functional analysis of proteins and macromolecular complexes . I joined NanoImaging Services NIS , a leading provider of CryoEM and TEM services , in 2019 where , amongst other projects , I have been spearheading our microcrystal electron diffraction MicroED development efforts . Over the past two years we have developed a reliable pipeline for MicroED structure determination including sample preparation , data collection and data processing . A particular focus of mine has been on automating and streamlining as many of the steps as possible , including adapting Leginon to collect high quality MicroED data and automating several of the data processing steps . In January 2020 , NIS officially launched MicroED structure determination services for small molecules of interest to the pharmaceutical industry and we have now collected data from over 50 small molecule samples . In 2021 we were awarded an SBIR grant from the NIH NIGMS to further our MicroED development efforts and address some of the challenges that remain to be solved for both small molecules and proteins . Highlights Accomplished structural biologist with over a decade of combined experience in crystallography and single particle cryo electron microscopy . Passionate about enabling structure based drug design SBDD . Established microcrystal electron diffraction MicroED capabilities at NanoImaging Services and regularly determine small molecule MicroED structures . Extensive experience at every level of the gene to structure pipeline . I have a deep understanding of the biochemical and biophysical tools available to produce high quality samples . Proven track record of tackling difficult data processing problems in crystallography and cryoEM . Not afraid to dive deep and push the limits of what we think is possible . . Technologies : Xray;CryoEM",proteins;small molecules;structure
"Senior Research Scientist . Senior Research Scientist in Discovery ADME department . Quantitative LC MS Plasma Protein Binding Metabolite ID In Vitro Plasma Stability . Strong background in scientific research obtained through years of industrial experience at Novo Nordisk A S and as visiting PhD student at the laboratory of Professor Albert J.R. Heck Core competencies in LC MS characterization and bioanalysis of biotherapeutics using state of the art liquid chromatography , mass spectrometry and software solutions , with emphasis on development and establishment of novel methods on complex tasks , such as disulfide bond mapping of proteins with closely spaced cysteines Independent , creative and innovative thinker ; quick learner and team player with lots of positive energy Noteworthy presentation , collaboration , and organizational skills obtained through scientific projects , but also by chairing of a condominium association board . Technologies :",
"Senior Principal Scientist , Head of Structural Biology . Joined Deep Apple Therapeutics an Apple Tree Partners portfolio company as a founding scientist to combine capabilities in molecular docking and structural biology to create a nucleus for accelerated drug discovery . Applying a state of the art technology research platform based on advanced computational modeling large scale compound docking LSD , cryo EM based structural biology , and deep learning to drug discovery . . Experienced research scientist with 10 years of experience in protein biochemistry , structural biology , and biophysical techniques on drug targets such as GPCRs and cytokine receptors . Leading qualifications are single particle cryo electron microscopy cryo EM , protein NMR spectroscopy , fluorescent based assay development , and recombinant protein expression purification using chromatography techniques .. Technologies : CryoEM;NMR",biologics;developing;stability
"Translational Medicine and non clinical Lead . My team is responsible for e.g. developing novel exploratory translational medicine clinical biomarker studies providing Immunology scientific input during clinical trials e.g. biomarkers , proof of concept , drug efficacy potency target engagement , toxicology etc . o Prepare , execute , review and support clinical documents , assay development strategies , protocols , clinical trial reports and relevant sections of Investigational Medicinal Product Dossier , Investigator Brochures , safety reports , briefing documents , INDs , NDAs , and other regulatory documents o Support in licensing and out licensing activities and partner relationships . o Interact support oversee studies , both internally and with external stakeholders CROs , vendors , trial sites , third parties . o Consideration Investigation of the feasibility of new technologies enhancement within the immunology and cell biology field flow cytometry , cell sorting , multiplex cytokine profiling Luminex MSD , live cell imaging , live cell and high content microscopy inclusive artificial intelligent based data analysis . Always open for a new challenge , always eager to expand my horizon . Passionate , innovative and highly accomplished PhD Scientist with extensive experience in Immunology , Cell Biology , Innate Immunity Inflammation , Autoimmunity autoimmune diseases , dermatology immunology , in vitro ex vivo assay development , in vivo animal models as well as small molecule biologics drug development , high throughput screening development and implementation , clinical proof of concept single or multiple indications Specialties : Immunology , Innate Immunity Inflammation , Autoimmunity Cellular Immunology Cell and Tissue Culture primary human cell purification cell sorting and manipulation e.g. T cells , B cells , Dendritic cells , macrophages , ex vivo tissue models e.g. skin , cell based functional assays and immunoassays Pharmacodynamics PD , mechanism of action studies , biomarker strategie development Protein Biochemistry cellular and biochemical assays for small molecules , cell isolation sorting magnetic MACS , ligand receptor binding , cellular signaling , flow cytometry FACS immunophenotyping , ELISA , cytokine measurements multiplex immunassays Luminex , qRT PCR TaqMan RT PCR , gene expression analysis , high content imaging batch analysis Molecular Biology Assay development Genetic Mouse Models In Vivo Animal Model Microbiology human pathogens Team Project Management skills multitask academic achievement first author research publications excellent written , verbal communication , analytical and critical thinking skills . Technologies :",proteins;small molecules;interaction
"Bioinformatics Scientist . The design of bioinformatic tools for the study and characterization of transport systems across organisms and their evolution . Typical tasks include the identification of functional relationships with other types of proteins , their physical interactions , as well as the biological processes in which they participate . . Specialties : Comparative Genomics , Functional Genomics , Molecular Evolution , Cellular Transport , Genome Annotation , Bioinformatics , Statistics , Data Mining .. Technologies :",
"PhD candidate . Pioneered in structural and mechanistic characterization of enzymes catalyzing biosynthesis and degradation of ergothioneine Discovered an unprecedented catalytic step in copper dependent enzymes using cutting edge X ray crystallographic methods Characterized new halogen methyl transferases capable of SAM cofactor regeneration in methyl transfer reactions for biotech application Protein expression and purification E. coli Full structural biology workflow from sample preparation to structure analysis X Ray crystallography , cryo EM Standard molecular cloning procedures PCR , mutagenesis , transfection Design of Experiments DoE , data analysis and interpretation HPLC , LC MS , HRMS , ITC , NMR , kta systems , Mass photometry , automated robotic systems Bioinformatics Actively collaborated with other research groups BZ , DBSSE , Freiburg , PSI , HZI . Creative , goal oriented and passionate multi disciplinary scientist with more than 5 years hands on experience in biochemistry , structural biology , organic chemistry and bioinformatics . Inspired by the enormous potential of biotechnology I aim to encounter today s smaller and bigger global challenges as part of a responsible organisation . My interpretation of research is driven by a strong belief into the superior power of collaborative interdisciplinary efforts of highly motivated and professional individuals . Professionally , I rely on my strong organisational communication capabilities to build solid relationships , and I appreciate taking over responsibilities and solving problems . . Technologies : Xray;CryoEM;ITC;NMR",enzymes;characterization;interaction;structure
"QA Principal Scientist . QA Principal Scientist , Device , assembly Packaging , QA Pharmaceutical Production , Hiller d Key responsibilities : Quality responsible for Finished Products QA departments Hi , Global Quality responsible for FlexTouch packaging and FlexPen assembly requirements for production and batch documentation , global Leadership Activities , Validations and implementation of packaging lines and collaboration with CMO , Participated in audit and inspections from FDA , EMEA CFDA etc . External activities , over site activities . . 22 years of experience working with Quality assurance of biopharmaceutical products injectable , liquids ; covering Finished Products , Aseptic Production , Assembly and Labeling Packaging . Senior QP Qualified person and Expert in quality assurance of Pharmaceutical Production . Experienced in quality assurance of validation production processes , equipment , project work including quality risk management Experienced in auditing Experienced in collaboration with CMO and managing project work Experienced in stability quality assurance heat studies for protein drug products during and after assembly and packaging . International role in project teams as QA expert . International role : QA coordinator Expert for Novo Nordisk sites in Denmark , France , USA and Brazil More than 20 years experience in complex problem solving activities in Finished Production , Release competencies and Quality Assurance More than 20 year s knowledge and interpretation of cGMP and ISO . Quality management systems implementation and maintenance Production technologies and equipment knowledge related to the pharmaceutical industry . IT experience and knowledge Validation and qualification of processes , equipment IT Ability to motivate and lead people in change processes . . Technologies :",biologics;quality
"Doctoral Researcher . Executing different simulation techniques in time evolution of biomolecules such as peptides and proteins to gain detailed information of structural preferences and mechanisms of folding Feature engineering of row atomistic datasets to obtain interpretable data and create a predictive model using machine learning or statistical modeling Implementing unsupervised machine learning techniques , e.g. clustering and dimensionality reduction , to uncover trends , patterns and correlations in the feature data Predicting the chemical and physical properties of biomolecules through supervised machine learning , e.g. deep learning and graph neural networks . Since the beginning of involving in computational physics and biology , I have been introduced to the world of data science and necessity of it in obtaining deeper insight in scientific datasets . My interest led me to become passionate data science PhD researcher who believes in actionable data insights in scientific projects and life long learning in AI subjects . I implement data science pipelines in biophysics to draw insights to the data and critically evaluate the quality of the results through machine learning . I am excited to learn and implement various machine learning techniques of big data analytics to solve problems in physics behind biomolecules ' behaviour . I am fluent in Python , R , database , machine learning , deep learning , data visualization and graph neural networks . Moreover , I am always interested to network with other professionals in this field and participate in data science events . I have also advantages in communication and project management skills . As a next step , I would like to accomplish my PhD project and start a career in data science .. Technologies :",
"Bioinformatics Data Scientist . . I am working at Data Science Institute DSI . In addition to the state of the art data observatory , DSI provides cutting edge data dependent analytical solutions to clinical , financial and environmental problems to name a few . People at DSI have various scientific and engineering abilities but they all share the passion and interest in the data .. Technologies :",
"Research Technician III . Design , expression , and purification of neuronal vesicle fusion proteins . Over 1.5 years of experience in drug target discovery , cytotoxicity screening of novel compounds , and cell culture of various cancer cell lines . Over 7 years of experience in the production , crystallization , and structure determination of proteins . Over 17 years of experience in molecular biology techniques such as PCR cloning , plasmid mini preps , DNA purification , gel electrophoresis , BP and LR reactions Gateway cloning system , Invitrogen , Western blots , and detergent solubilization , as well as in protein expression using Escherichia coli and purification using a variety of chromatography techniques IMAC and SEC , among others . Experience in the culture of Hela , BSC40 , BHK , 3Y1 cell lines , as well as numerous cancer cell lines . Over 11 years of experience in lab management such as ordering , preparation of buffers and reagents , general lab equipment maintenance , and over 5 years of experience training personnel in molecular biology techniques .. Technologies :",proteins;small molecules;developing;expression;screening
"Scientific Specialist . . Scientist , drug discovery oriented , specialized in GPCRs and signal traduction with experience in Neurosciences and Immunology . . Technologies :",membrane proteins;screening
"Research Fellow . Elucidated molecular mechanisms of 8 proteins and their complexes using cryo EM and X ray crystallography Designed 8 protein constructs based on sequence analysis and structural prediction Cloned and purified 20 protein constructs using chromatography and gel electrophoresis Mentored 2 undergraduates and 2 graduate students on experimental skills and scientific communication skills Collaborated with 18 researchers , including biologists , chemists , and physicists , from 5 institutes on 14 projects Preparing 3 papers as lead author , and have co authored 4 papers in influential journals . . Technologies : Xray;CryoEM",proteins;structure
"Lead Data Scientist Research . . Experienced computational physicist with a record of developing and applying statistical modeling and molecular simulations to the analysis of complex systems . INTERESTS AND EXPERTISE Physics and Applied Mathematics : Equilibrium and non equilibrium statistical mechanics , Stochastic thermodynamics , Complex systems and nonlinear dynamics , Stochastic processes , Statistical mechanics of neural networks , Markov Chain Monte Carlo methods , Molecular Dynamics , Stochastic processes , Chemical kinetics , Spatial stochastic simulations , Statistical learning , Information theory , Statistical data analysis and signal processing , Adaptive time series modeling and analysis , Temporal synchronization , Pattern recognition . Biology and Biochemistry : Origin of life on Earth , Protocell modeling , Electrodiffusion and membrane proteins , Nanopore mediated molecular transport and sensing , Synchronization in biological networks , Protein folding and aggregation , Biomolecular self assembly , Protein design . Computer Science and bioinformatics : Scientific programming and algorithm development in Python , Fortran and C . Unix based OSs : Linux , Free BSD . , MacOS . Technologies :",
"Principal Bioinformatics Scientist . . A Silicon Valley veteran , I have a successful track record of driving group engineering efforts , developing innovative software , and , as co founder and President , guiding the growth of Handmade Software from a startup to a stable , highly respected company with several products . Turning to apply my technical expertise to genetics , a personal interest , I earned a PhD in Bioinformatics at UC Santa Cruz in 2015 , culminating in several publications , innovative algorithms , and new and effective techniques to optimize high throughput screening .. Technologies :",
"Research Investigator . . At university , I studied chemistry , and started to become more and more interested in the relationship between molecular structure and properties , mainly biological activity . Computational chemistry turned out to be the way to go . However , I still did some experimental work while pursuing my Ph . D. After a couple of years as itinerant post doc , I started to work as computational chemist in the pharmaceutical industry , supporting drug discovery projects from early phases to candidate selection . My scientific journey started with GPCRs and has expanded to esterases , kinases , ion channels , proteases , and nuclear hormone receptors . My scientific interests include virtual screening , the analysis of crystallographic data both small molecules and proteins , binding sites comparison , fragment based screening and biophysics . . Technologies :",
"Director of Computational Chemistry . managing and leading the computational support to external drug discovery projects leading the physics driven and AI driven computational platform development contributing to business development . Computational chemist with a deep understanding of force field , free energy and structure based drug design . Interdisciplinary background spanning computational modeling , informatics and management consulting .. Technologies :",
"Senior Research Scientist . CMC Injectable Formulation Development . Injectable Formulation Development Formulation and stability of protein and antibody products Key competence : Drug development from phase 2 to marketing . Protein and antibody delivery and formulation development . Building regulatory strategies and authoring of key regulatory documentation , for IMPD , NDA , BLA , MAA etc . Pharmaceutical manufacturing process development Analytical techniques such as : CD and HPLC . cLean educated and experienced in optimizing and simplifying processes . Technologies :",antibodies;biologics;proteins;formulation;stability
"Computational Biologist . I invent mathematical models to detect mutations and other patterns in genetic sequencing data using a variety of techniques included probabilistic graphical models , deep learning , and computer science algorithms . My colleagues are the nicest , most creative bunch one could possibly hope for . I am always happy to talk about computational biology with people , including complete strangers , considering it as a career . . . Technologies :",
"Associate Professor . . My research aims at understanding the interplay between disruptions in lipid homeostasis and neurodegenerative disorders , such as Parkinson 's Disease . In order to address this question , we use a multidisciplinary approach at the interface between biology and biophysics including the study of different disease cellular models and the characterization of protein membrane interactions and aggregation at the molecular level . More information can be found here : https : drug.ku.dk disciplines molecular and cellular pharmacology galvagnion group . Technologies :",idps;membrane proteins;interaction
"Staff Scientist . . Bioinformatics lead at IFF , Palo Alto . Provide bioinformatics support for microbial strain engineering teams , focusing on genomics , transcriptomics and metabolic pathway engineering . Bioinformatics specialties include : Next Generation Sequencing NGS , RNAseq , Genomics , Statistical Analysis , Machine Learning , Multivariate Analysis , Position Weight Matrices . Background in molecular , micro , synthetic and computational biology . Extensive experience in bacterial gene expression , stress responses , design of synthetic genetic circuits , and computational analysis of transcriptional systems . . Technologies :",
"Principal Bioinformatics Scientist . Developed and deployed full data processing software pipeline that is run locally on an instrument that performs all microfluidics , microarray imaging and data analysis functions necessary for processing plasma samples for Non Invasive Prenatal Tests NIPT . The pipeline includes microarray image processing and all data analysis steps necessary for aneuploidy diagnosis . Developed algorithms to register and extract probe intensities from Agilent microarray images , including selection of best focus image , illumination correction and background determination and subtraction . Developed and implemented statistical models and algorithms to accurately estimate fetal fractions and call fetal aneuploidies from maternal cell free DNA plasma samples . Developed an algorithm for calling Copy Number Variation CNV segments from microarray data that employs modified version of Hidden Markov Model . Pipeline was developed in Python 3.7 and uses multiprocessing to efficiently utilize available CPUs . Pipeline uses OpenCV package to take advantage of the fast GPU on the NVIDIA Jetson TX2 processing card on the instrument . Developed automated data and analysis visualization solution using Google Big Query and Tableau . Helped drive process improvements by performing statistical analyses of cohort datasets to provide feedback on sensitivity and specificity of our test solution and their dependence on fetal fraction . . Specialties : Machine learning algorithms , statistical modeling and analysis .. Technologies :",
Director Of Bioinformatics . Harnessing the power and potential of the hidden realms within and around us microbes for human and planetary health . My goal is to bridge the technical and practical aspects of biology and software engineering to enable powerful insights into the human microbiome . It is my dream to unravel the mysterious ways by which the trillions of microorganisms that inhabit our bodies shape our health and well being throughout our life . I currently develop novel algorithms for optimal high throughput characterization of microbial communities . Check out my Google Scholar profile for publications I 've contributed to . https : scholar.google.com citations user F8V9 agAAAAJ hl en . Technologies :,
"Director , Algorithms R D . Leading a team talented scientists developing algorithms and analysis solutions for PCR , CE , Microarray and NGS products . . Technologies :",
"Phd Student . . Significant improvements of the spatial resolution of cryo electron microscopy has enabled high resolution structure determination of proteins and protein complexes using tomography and single particle analysis . Structure determination to 4 resolution was previously accomplished using X ray crystallography , but in the last 5 years the number of high resolution structures from cryo EM single particle analysis has increased dramatically . It is predicted the number of cryo EM structures can match the number of structures from X ray crystallography in a few decades . Structures of membrane proteins have been a challenge to elucidate with X ray crystallography , as many membrane proteins are hard to crystallize . This limitation is not faced by cryo EM as this method can be used to image particles directly in a natural , membranous environment . This opens the possibility to elucidate structural details of protein complexes located in the synapses and even to obtain a high resolution view of synaptic structures in the brain . Synaptic plasticity associated with emotional memory represents an attractive model for investigations of memory formation and consolidation . Experimental evidence suggest that memory becomes short term if the synthesis of plasticity related proteins PRPs is blocked , but the nature of those particular proteins remains to be characterized in detail . This is currently being done by mass spectrometry on samples under optogenetic control of memory formation at the newly established PROMEMO center of the Danish National Research Foundation . The aim of the proposed PhD project is to characterize isolated PRPs and PRP complexes in synaptic membrane like environments in structural detail using cryo EM methods and compare it to control samples . . Technologies : Xray;CryoEM",proteins;characterization;interaction;structure
"Principal Scientist II . . Highly skilled Bioinformatics Computational Biology analyst and team leader Experienced in both research and regulatory environments Expertise in predictive sciences for translational bioinformatics in Oncology and other disease areas : includes integrative analyses of omics data from both pre clinical and clinical sources , serving pharmaceutical target discovery as well as diagnostic biomarker discovery and development . Long history of success at joining biology and computation to solve hard problems serving key goals Rare combination of strong background , rich skill set , creativity , practicality , collegiality , and clear communication . Technologies :",
"Application Scientist . Using NLP text analytics as a member of the Business Development team , to solve real world problems of our customers and contribute to Linguamatics IQVIA business operations growth . . I have 10 years of research experience working in infectious diseases and cancer genomics . I have gained bioinformatics and computational biology skillsets during this time . My multidisciplinary training makes me unique , in that I can leverage a variety of skills to provide solutions to complex problems such as conceptualizing research questions ; designing , managing and carrying out experiments ; analyzing experimental results ; presenting findings and preparing manuscripts . As a genomic specialist with IBM Watson Health , I worked with a cross functional team to define , design and develop new personalized cancer medicine solutions using AI , genomics , bioinformatics and data analytics . As a post doctoral research fellow , I studied clonal evolution and examine feasibility of cf DNA as a liquid biopsy in leukemia using single cell genomes and cell free DNA datasets . I built and maintained computational pipelines , and worked closely with wet lab biologists to analyze next generation sequence data . Previously as a graduate student , I used evolutionary biology , functional genomics , molecular and cell biology techniques to study genome evolution of apicomplexan pathogens . While in graduate school , I gained extensive knowledge and skills in genetics , parasitology , computing , and science communication through academic and extracurricular training . Competencies : Shell scripting Bash , Python , and R High Performance Computing UNIX LINUX Somatic and germline variant calling Targeted capture probe design Phylogenetics Clinical , genomic , and biomedical databases Benchmarking bioinformatics software Client facing Biocurator Regular Expression Data Visualization AWS Quicksight and Tableau NLP Analytics I2E. Technologies :",
"Cryo EM Director . . Experienced scientist with a demonstrated history of working in the research Institutions in the field of Structural Biology and biochemistry . Skilled in Membrane Proteins , Voltage gated K ion channels , Ion channels in regulated secretion , Confocal imaging , Biochemistry , Membrane Biology , Cell culture , Protein overexpression and purification , Protein Chemistry , SDS PAGE , Fast Protein Liquid Chromatography FPLC , High Performance Liquid Chromatography HPLC , SEM , TEM , UV Vis Absorption , Fluorimetry , Xray Crystallography and Cryo Electron Microscopy Single Particle Reconstruction . Strong research professional with a Ph.D. in Structural Biology and Biochemistry . . Technologies : CryoEM",membrane proteins;characterization;expression;structure
"Senior Formulation Scientist . . Experienced Formulation Scientist with a demonstrated history of working in the pharmaceuticals industry . Skilled in diverse Drug Delivery technologies , Formulation science and Pharmaceutical Research . . Technologies : Xray;SLS DLS",
"Clinical research manager neuroscience , rare diseases . Strong working experience with neurodegenerative disease , machine learning , , brain computer interface , Alzheimer , epilepsy . Intensive working experience with startup activities Working experience Phase I , II and III UK , US , EU Machine learning , robotics , neurolinguistics Neurodegenerative disease , oncology , rare diseases Phase I , Proof of concept , quality by design Ability to manage complex operations and projects under tight deadlines Strong team collaboration , leadership , issue identification and resolutions Excellent knowledge of ICH GCP , CFR 21,MedDev IWRS , Python , Matlab , datamining . . Technologies :",
"Senior Bioinformatics Scientist . . Expertise in single cell RNA Seq , bulk RNA Seq , DNA Seq , ChIP Seq , Cut and Run , Hi C. Specialized in integrating high throughput multi omics dataset , including genomics , metabolomics , and proteomics . Proficient in multiple programming languages including Python , R , Perl , SQL , Bash , HTML CCS . Experienced in pipeline automation , tool development , and interactive visualization . Familiar with statistical modeling and machine learning .. Technologies :",
"Associate Bioinformatics Scientist . Developed data mining tools that integrate into FlowJo a java based data analysis software for flow cytometry for the purpose of developing new A.I. training data sets . Rebuilt existing deep learning code base to utilize Pytorch for ease of use . Developed various ML and deep learning algorithms , for assay automation purposes , capable of identifying specific cell populations with an accuracy greater than 91.9 percent . Planned and executed experiment protocols to understand why models were failing and subsequently developed models capable generating synthetic data for rare cell populations with multi modal distributions . Built software system to integrate Pytorch based ML models into FlowJo s plugin using a client server architecture so that we can integrate newly developed tools into existing workflows . . Hello , I am a recent graduate from UC Berkeley with a degree in Bioengineering and Computer Science . I am very passionate about engineering solutions to difficult and impactful problems . My interests lie in software engineering , machine learning , bioinformatics , and entrepreneurship . Feel free to reach out to me via email at arjun chandran berkeley.edu .. Technologies :",
"Manager , Bioinformatics Services , Expert Bioinformatics Scientist . Supervised Application Scientists on bioinformatics projects and software improvement strategies . Provided leadership , guidance , and technical expertise to cross functional teams including collaborations with Scientists , R D , Marketing , QA , Support , and Upper Management for proposing new Agilent initiatives , clinical opportunities , and improvements in informatics software quality . Proactively uncovered critical software issues affecting clinical analysis results leading to substantial cost savings , improvements in software R D Quality , and improved customer satisfaction . Provided bioinformatics and clinical expertise for product troubleshooting , bug fixes , product enhancements and customer based collaborative partnerships in industry and academia . Strengthened development of bioinformatics pipelines to support software for Agilent CGH arrays and target enriched NGS platforms SureSelect , HaloPlex , OneSeq for variant aberration calling . Debugged and tested Agilent SureCall , CytoGenomics , and SureDesign software . . Expert Bioinformatics Scientist , Team Lead and entrepreneur with 10 years experience . As an entrepreneur , I am the co founder and COO of Tranzend , a biotech startup designing a blood screening test for breast cancer . My technical expertise spans mining clinical preclinical next generation sequencing NGS and microarray data , and developing novel computational methods for human genetics , functional genomics , and clinical translational research . At Agilent Technologies , I provide leadership , support , and technical expertise to both customers and internal stakeholders with the goals of improved software product pipelines , heightened focus on product quality validation verification , and greater overall customer satisfaction for the next generation sequencing NGS and array CGH platforms . My technical experience includes the analysis of data from both of these technologies , along with scripting and pipeline development ; QC visualization ; expression profiling ; statistical analysis and machine learning ; variant calling ; and software engineering . At Rutgers Cancer Institute of New Jersey , my bioinformatics expertise led to innovative research initiatives resulting in new grant awards , six publications , and two patents . I also played a critical role in managing the NGS microarray program along with leading collaborative oncology research teams biologists , core facility technicians , clinicians , and bioinformaticians as part of a successful NCI Comprehensive Cancer Center designation renewal , including an Outstanding rating for Bioinformatics . My leadership and cross functional capabilities are complemented by my strong programming background Java Sun certified , R , Perl , C , SQL , PHP , JSP , and Unix shell scripting and my NGS expertise , including RNA Seq , Exome Sequencing , ChIP Seq , Whole Genome Sequencing , and extensive knowledge of common NGS tools .. Technologies :",
"Undergraduate Researcher . Studying systems biology of microbial communities through computational , mathematical , and deep learning techniques . . I am interested in the applications of computing and physics to characterize complex biological phenomena as well as building high quality software .. Technologies :",
"Expert Statistical Scientist . . Passionate about innovative applications of mathematics , computer science , and statistics in improving human health . Technologies :",
"Senior Scientist II , Computational RNA Biology , Machine Learning . Design of effective RNA medicines by multiplexed experimentation , molecular modeling simulation , and machine learning . . Advanced machine learning scientist and computational biologist with tremendous performance record and vision . Experienced in Large Scale Bioinformatics , Data Science , Machine Learning , and Molecular Engineering .. Technologies :",
"Senior Scientist . Screening analytics : informatics workflows for IDing lead molecules from high throughput biochemical and cell based screens . Characterize and predict molecules ' SAR , off targets , or activity as molecular glue degraders . Machine Learning : NLP inspired models predicting candidate targets of molecular glue degraders or PROTACs . Also generative models to enable high content imaging assays . Systems Pharmacology : Development of mechanistic models systems of ODEs and PDEs to identify new drug targets , characterize therapeutic strategies i.e. inhibition vs degradation , predict drug selectivity requirements , etc . . Matt is an outgoing and creative Ph.D. level engineer scientist , interested in quantitative systems pharmacology , mechanisms of protein signal transduction , and science leadership . Notables : Enthusiastic and hard working engineer scientist Ph.D. Biomedical Engineering with a strong background in both computational modeling and bench top laboratory work . Knowledge in the biosciences such as neuroscience , infectious disease , toxicology , chemical biology , and physiology . Recent work in post hoc analysis of clinical outcomes trials using machine learning , in part to identify new applications for pharmaceuticals treating diabetes and cardiovascular diseases . Background in computation : Monte Carlo algorithms , ODEs , PK PD , machine learning , rule based modeling , image processing , parameter estimation , sensitivity analysis , numerical analysis and optimization , statistics , and programming Matlab , Python , R , C Ten years of hands on experience with laboratory techniques such as Western blot , ELISA , RT PCR , cell culture , and affinity chromatography Strong interpersonal and communication skills as evidenced by numerous peer reviewed journal publications , conference presentations , high level leadership positions , and recognition in teaching and instruction .. Technologies :",
"Senior Director Global Medical Affairs . Leading medical affairs at MoonLake Immunotherapeutics AG , a clinical stage biotechnology company focused on creating next level therapies for inflammatory skin and joint diseases with Nanobody science . Entrepreneurial , forward thinking and results driven medical affairs professional and strategist . Passionate about translating the science of immunology into innovative and life changing medicines for people living with serious and debilitating inflammatory diseases . Proven cross functional leadership skills at both global and regional level , implementing change and leading remote teams in inflammatory disease areas . Experienced at launch preparation with strong commercial acumen and customer centric mindset and effective contributions to products through the pre and post license phase in dermatology and rheumatology . Skilled in drug discovery , translational medicine and implementation of impactful scientific collaborations with leading external experts and academic institutions . Currently leading medical affairs at MoonLake Immunotherapeutics AG , a clinical stage biotechnology company focused on creating next level therapies for inflammatory skin and joint diseases with Nanobody science . Core Competencies : . Dermatology Rheumatology Immunology Inflammation Medical Affairs Clinical Development Strategy Leadership Engagement Medical Education Leading Teams Presentation Skills Publications Public Speaking Regulatory Affairs Benefit Risk LCM Evidence Generation . Technologies :",antibodies
"Assistant Professor . My laboratory focuses on the development and application of computational tools for modeling large macromolecular complexes . We work on a number of biological systems including membrane proteins , viruses and cancer immunotherapeutics . . My research focuses on developing and applying novel computational tools to model complex biological systems .. Technologies :",
"Bioinformatics Engineer Product Owner . . As a driven leader , I have used my skills in Computer Science , development and Computational Biology in dozens of projects . I have extensively studied several languages , including C , Java , R and Python . I love learning new skills in a variety of disiplines and am always up for a challenge .. Technologies :",
"PhD graduate student . My thesis focuses on the role of a multifunctional actin regulator , cyclase associated protein , in actin dynamics . I received a 4 year PhD Fellowship from the doctoral school in life sciences ILS , University of Helsinki in the group of Academy Professor Pekka Lappalainen . Results and skills : Three first author publications published in Nature Communications , and contributions in nine other scientific articles . Protein production : E.coli and Bac to bac ExpiSf insect cells system . Cloning of protein construct libraries for crystallization trials Rf cloning , Gibson assembly , restriction cloning , site directed mutagenesis Purification of proteins with various fusion systems SUMO , Strep , His tag , GST , tissue . Analysis of protein complex formation and interactions gel filtration , flourometric binding assays , Native PAGE , SDS PAGE , Thermofluor Crystallization of proteins in the core facility by utilising Minstrel DT UV Protein Crystal Imaging System and TTP Labtech s mosquito LCP liquid handling Successful structure determination two protein complexes involved in catalyzing nucleotide exchange on actin monomers and disassembly of actin filaments . Remote data collection at Diamond beam lines . Protein complex preparation and imaging of negative stained EM samples . Sample preparation for cryo EM . Maintenance and use of AKTA protein purification machines AKTA Pure and training of new users . Confocal imaging of fluorescently labelled actin filaments Generation of stably expressing mammalian cell lines , imaging and expression analysis Western blot Supervision of students Communication skills between different disciplines of science biophysics , MD simulations , cell biology , biochemistry , crystallography Drafting , writing and editing of manuscripts and figures Oral presentation skills to broader audience in several meetings seminars . I have a PhD training in solving diverse scientific questions from cell biological , biochemical , biophysical and immunological aspects . Thus , I am very experienced in communicating and working in projects with colleagues from diverse professional and cultural backgrounds . I believe the most challenging problems are best tackled in a multidisciplinary environment . I am used to working in teams and also managing team members . I am easy to work with , analytical by personality , and I pay attention to details . I am able to adjust in quickly changing work environments and have constant willingness to learn and improve professionally . My most valuable skill is the ability to interpret scientific knowledge and recognize the most critical details from the vast amount of scientific information . I am passionate about science , but you would find me excited about various topics from economy to sports . In the forthcoming work environment , I would like to contribute to solving issues related to human health and disease .. Technologies : CryoEM",proteins;expression;interaction;structure
"Consulting in Drug Design . . Biomathematician , My research expertise is in the area of computational science , molecular simulation with a focus on advanced computer modeling of biological molecular interactions , specializing in computer aided design of pharmaceutical drugs . My research has addressed issues related to drug design for more accuracy allowing the study of new challenging targets . I am the author of a fully flexible docking software package called MORDOR which take into account one of the most challenging problems in virtual screening , an adequate description of receptor flexibility and its influence on ligand recognition . I applied MORDOR on numerous targets including the developement of small molecule inhibitors of HIV kissing loop RNA and small molecule inhibitors of the telomerase associated with the uncontrollable proliferation of cells seen in as many as 90 of all of human cancers Specialties : Drug discovery using virtual screening fully flexible docking . State of the art molecular modeling techniques to study biological system on a time scale compatible with those of biological processes .. Technologies :",
Associate Professor of Pediatrics . . Biostatistician with over 20 years experience in design and analysis of clinical data to improve patient care and determine the success of new treatments . Supervises multi disciplinary team in innovative statistical design and analysis of preclinical studies and phase I III multi center clinical trials as well as observational studies . Adapts quickly to understanding and analyzing complex projects and concepts . Effectively collaborates with researchers and technology developers on analysis and processes that ensure data integrity and accuracy . Provides strategic direction to executive leadership and external organizations to improve operations . Experience with CROs . Working knowledge of FDA regulatory filing process and CDISC . Known for excellent communication skills and strong relationships enabling timely completion and publication of innovative research .. Technologies :,
"Associate Computational Biologist II . . Associate Computational Biologist at the Broad Institute of MIT and Harvard working on projects related to tumor heterogeneity and cancer drug resistance in the Getz Lab in the Cancer Genome Analysis Group . Earned MEng degree from MIT in Computer Science in February of 2020 . Pursuing elite lightweight women 's rowing at Riverside Boat Club . Spent time in Berkeley , CA in summer 2017 using Amazon Web Services to create new company pipelines , analyzing NGS data , and creating interactive and informative data visualizations . Interested in genomic data analysis , pharmaceutical research , and health tech . . Technologies :",
"R D Scientist . Company Profile : . Xpress Biologics is a development and manufacturing company specialized in the production of Biologics recombinant proteins , antibody fragments , plasmid DNA for preclinical and clinical applications . The company 's main markets are therapeutics , vaccines , and diagnostics . Context : . Participation in the development and optimization of processes at the level of downstream processing DSP platforms . My Responsibility Activities : . Operate state of the art equipment AKTA Avant , Sartorius and different types of column chromatography IEX , HIC , Mixed Mode and filtration filtration and TFF ultrafiltration techniques to perform purification in a timely and quality oriented manner ; Be part of the team performing pilot scale or scaled down DSP campaigns to facilitate technology transfers to the CMO and provide non GMP Drug Substance material for toxicology studies ; Report results and progress to Project Leader and or client ; Prepare experimental reports , meeting summaries presentations and draft work protocols in English ; Assume one or more laboratory responsibilities to keep the various DSP and QC platforms operational at all times . . Bioscience engineer motivated by the life sciences sector , in particular health biotechnologies , applies his various skills in ambitious and innovative projects of tomorrow . . Technologies :",antibodies;biologics;developing
"Vice President , Immunology and Inflammation Drug Discovery . . A dynamic senior Bioscience Director with a wide range of experience in early drug discovery across a broad range of therapeutic areas and a proven track record in successfully delivering projects . Strong motivation for innovative science coupled with a natural drive to continuously improve the business . Specialities : . High Throughput Screening . Drug discovery bioscience . Project leadership . Group leadership and team player . Assay development . Respiratory Inflammation . Oncology . Nuclear hormone receptor biology . Fragment screening . Technologies :",proteins;small molecules;screening
"Research Scientist . . Profile : PhD in chemistry , specialized in protein biochemistry structural biology . During my scientific career I got aquanted with a variety of laboratory methods to engineer , purify and characterize both soluble and membrane proteins and was designing and leading projects both independently and in collaboration with internal and external researchers . I have valuable experience with the analysis and interpretation of scientific results and communicating complex biochemical processes to a broad audience . In addition I was involved in administrative and organisatory processes , such as risk assesment , planning trips to synchrotrons , applying for research grants and beamtime at synchrotrons and the maintainance of laboratory equipment and working environment . During my employment in industry I improved in efficiently working on a number of projects in paralell through prioritizing and proactive planning . My collegues describe me as positive and open minded with strong team working skills . I am flexible and embrace new ideas and challenges to efficiently solve demanding problems . I am constantly striving to implement my knowledge and develop both scientifically and personally . SKILLS : Project management Scientific communication Scientific writing Organization Mentoring METHODS : Construct desing Cloning Cell cultivation bacterial and murine cell cultures Protein engineering Protein purification Recombinant protein production Chromatographic techniques and fractionating Enzyme activity assays Differential scanning fluorimetry DSF and Nano DSF Small and wide angle x ray scattering SAXS and WAXS Protein crystallization X ray crystallography and structure determination of proteins . Technologies : Xray;DSF",membrane proteins;proteins;characterization;structure
"Researcher . . Research interests : Immunoregulation , PET tracer development , Immuno PET , Targeted therapy , Radio immunotherapy , Radiolabeling , Protein Engineering , Tumour microenvironment , Immune cells trafficking , Stem cells , Tissue engineering , Regenerative medicine , Cartilage regeneration , 3D culture , Biomarkers , Paracrine signalling , Exosomes , and Drug Delivery .. Technologies :",proteins;engineering
"Research Group Head . . Research Scientist with expertise in Metagenomics , Bioinformatics , Computational Biology , Genetics and Innate Immunity Specialties : Microbiota , Metagenomics , Bioinformatics , Computational Biology , Promoter Analysis , Gene Regulation , Molecular Biology , Next Generation Sequencing , Innate Immune Response , Genetics , Antimicrobial Resistance , Infectious Disesase and Immunology . Technologies :",
"Machine Learning Researcher . . I am a computational biologist with formal training in biochemical engineering . Having discovered a passion for computational biology during my Masters , I embarked on a PhD in computational and stem cell biology which I am on course to complete in October 2021 . My research interests are focussed on trying to maximise the learning that can be gained from complex data sets by attempting to reduce them down to their most informative aspects . In synthetic biology this may be identifying the most relevant genes relating to a desired phenotype , while in medical diagnostics we may seek to maximise our confidence in suggesting the next test that will lead to a successful diagnosis . For my PhD I have developed techniques to identify and eliminate uninformative features in high dimensional , noisy single cell RNA sequencing data scRNA seq , to amplify the signal of biologically relevant genes . I am currently searching for postdoctoral or industry based research positions working at the intersection between data science and the life sciences .. Technologies :",
"Bioinformatics Researcher . Dr. Animesh Sinha MD PhD and Dr. Kristina Seiffert MD Pemphigus vulgaris HLA Binding Site Identification and Genomic Expression Analysis using NGS techniques Responsibilities : Developed and executed pipelines to analyze microarray and RNA seq data from P. vulgaris , using python , R , and Linux , to compare gene expression levels in active and remittent , versus control patients Designed and executed a set of experiments to functional validate both the NGS experiments and signatures found during analysis . A part time graduate bioinformatics student at Johns Hopkins looking for opportunities involved with NGS analyses , infectious diseases , and immunology . A motivated , published , individual who has experience working in laboratory settings on assays such as DNA extraction , PAGE , PCR , RT PCR , Western blot , Northern blot , Southern blot , and using NGS sequencers Illumina . Non laboratory skills include knowledge of python , R , JAVA , C , C , and is familiar with Windows and Linux environments . Also has professional certification in Excel from iACT . Has industry experience working on multiple research teams , with deadlines and goals set forth by primary investigators ; meeting every deadline and goal without fail . Brings to the table both knowledge of bioinformatics , eagerness to continue learning , and passion for scientific research .. Technologies :",
"Principal Scientist . . My lifelong love of learning began in second grade math class where I was likely the most gleeful student of multiplication tables in my home state . A handful of science fairs later , I also developed a deep interest in human health and the human condition . This naturally lead me to pursue a degree in Cybernetics at UCLA . Years later , I completed a doctorate in Biomedical Engineering , followed by a post doc in systems biology and now a career in the pharmaceutical industry . I m passionate about applying new technologies , including deep learning , blockchain and systems biology to help quickly develop breakthrough therapies for patients . I value efficient , transparent , interdisciplinary collaborations that focus on the ultimate goal of improving the lives of others .. Technologies :",
"Senior Research Associate . . Specialties : Computer simulations , mathematical modelling . Domains : Population dynamics and infectious diseases ; Solidification of alloys ; Fracture dynamics .. Technologies :",
"Associate Computational Biologist . . I 'm a researcher in computational biology at the Broad Institute in Cambridge , MA , and I 've been loving the types of challenges I face daily in this work . Previously , I was a full stack software developer at Epic in Madison , WI . I graduated in May 2020 from Duke University with a Bachelor of Science degree in Computer Science and minors in Biology and Philosophy . I have been accumulating research experience and anticipate graduate school in my future . I have significant programming experience in Java , Python , and R , and also have experience working in C , JavaScript , TypeScript , SQL , C , HTML CSS , MATLAB , LaTeX , and MUMPS , and working with both Git and SVN for version control .. Technologies :",
"Associate Scientist , Computational Biology . . . Technologies :",
"Senior Scientist . . Pharmaceutical Biotech professional with in depth understanding of drug discovery process . A proven track record of achieving goals , prioritizing tasks and developing solutions to streamline operations . Solid background and experience within life science industries ; diagnostics and pre clinical drug development . Strong organizational and time management competencies . Experience in planning and coordinating cross functional efforts to meet project goals . Specialties : Project Management : Team leader for ion channel and GPCR targets , direct cross functional efforts important for the project . In vitro Assays : Develop , optimize and execute GPCR ion channels assay using FLIPR FDSS , cAMP , receptor binding , chemotaxis , b arrestin , and ELISA . Technology : Electronic biological data capture . Experimental data review analysis and liquid handling bio analytical software . Proficiency in ABASE , Softmax Pro , Graph Pad Prism , Word , Excel and PowerPoint . Certificate in clinical development and regulatory affair . Knowledge and exposure with clinical monitoring , data management , study protocols , CRF , GCP , CDISC standards , ADAM , SDTM validation . Technologies :",membrane proteins;interaction;screening
"Group Leader and Associate Professor . structural and functional studies of Mitochondrial Genome Maintenance Gene Expression . I am a cryo EM specialist and biochemist and have successfully run a range of research projects covering aspects of protein synthesis and quality control in my PhD and postdoctoral work . Currently , I am a group leader at the Novo Nordisk Foundation Center for Protein Research , where our lab investigates molecular working principle of genome maintenance and RNA maturation in human mitochondria .. Technologies : CryoEM",nucleic acids;structure
"Senior Computational Biologist . I have been leading the development of the processing and analysis pipeline of our single cell ATAC and joint scATAC Gene Expression products . More recently I 've been developing multiple internal data analysis and processing tools as well as joining development on our upcoming in situ RNA sequencing assay . . After many years in academia doing extensive computational biology research , I 've transitioned into industry , with a new role as a bioinformatics scientist working to improve my company 's bioinformatics pipeline . A list of my published work can be seen below , along with a brief personal description of the work . If you do n't have access to scientific publication databases , please feel free to send me an email or a message and I 'd be happy to provide you with any information on my research you 'd like .. Technologies :",
Head of Core Facility for Cryo Electron Microscopy . . I am Structural Biologist PhD using any kind of cryo EM to solve structures of macromolecular assemblies . Have a look at my previous work . Technologies : CryoEM,proteins;structure
"Principal Scientist . . Scientist Master , PhD , postdoc , 8.5 years as professor group leader with 20 years of experience in the Targeting Protein Degradation TPD field . Currently working on the development of drugs based on the manipulation of cellular TPD pathways . Passionate about understanding physiological and pathological cellular states and seeking for creative ways to control proteins and signaling networks regulating several major human diseases .. Technologies :",biologics;molecular glues;developing
"Principal Scientist . . Bioinformatics software developer and scientist in the biotechnology industry . Delivers effective data processing automation using high value and high performance solutions . Has solid background in computer science , bioinformatics , and molecular biology . Technical proficiencies include : Data analysis and visualization : R , KNIME , Pipeline Pilot , SciPy , D3.js , Angular.js Scripting and Database : Python , Javascript , MATLAB , Perl , shell scripting , SQL Oracle , MySQL Programming Languages : Java , C C , OCaml , Scala , Fortran , Lisp Environments : Unix , Linux , Windows , macOS , Eclipse IDE , IDEA , Wing IDE Computer science : Algorithm development , data structure , programming language , data science , database systems Biology : High throughput parallel sequencing , mammalian cell culture , real time PCR , 2D gel electrophoresis , protein purification , sequence analysis , molecular biology . Technologies :",
"Scientific Advisor . . Managerial and professional experience over 45 years in big pharma , mid pharma and biotech industry leading roles from early drug discovery up to marketed products headed various departments in different companies medicinal chemistry , chemical research , DMPK , patent , project management , research support member of several management teams headed project and portfolio management organizations and acted as project leader leading roles in collaborations with other companies and institutions business development and negotiations due diligence during in and out licensing led task forces to develop new strategies and facilitate mergers engaged as expert witness in patent litigations Specialties : Scientific experience drug design and discovery in several therapeutic areas incl dermatology , metabolic diseases , obesity , inflammatory diseases , respiratory diseases , CNS diseases , pain and infection most aspects of medicinal chemistry and drug design development of novel technologies for structure based drug design of GPCR ligands radioligand development for metabolic , PET and SPECT studies published over 100 papers and book chapters and over 50 patent applications . Technologies :",membrane proteins;small molecules;developing
"Pharmaceutical Assessor Biologics . . Enthusiastic , motivated scientist with experience in cancer diagnostics and therapeutics in both academic and industrial based labs . I am also heavily involved in advocacy for improving patient care . . I successfully completed my PhD in Biochemistry and Immunology at Dublin City University in 2015 and subsequently spent a number of years working in early stage drug discovery novel T cell therapy and mAb bioprocess development . I am currently based in the HPRA where i work as a biological quality assessor , specialising in the CMC assessment of biological medicinal products , including mAbs , recombinant proteins , blood products , vaccines and ATMPs for Marketing Authorisation Applications , clinical trial applications and scientific advice procedures . I have published extensively in reputable journals and presented at numerous national and international conferences , wining several science communications awards . I m truly passionate about my work and always eager to connect with fellow like minded scientists . I would love to hear from former colleagues , managers , or just interesting creative folk , so feel free to contact me if you d like to connect . . Technologies :",biologics;quality
"Senior Scientist . . I have a strong background in production , purification and structure determination of a helical membrane proteins by NMR and X ray crystallography . Specifically , I have been involved in understanding signaling events that take place at the cellular membrane by investigating sulfurtransferases , potassium channels and the essential malarial protein conducting pore complex . In addition , I contributed to rapid NMR structure determination of human integral membrane proteins produced via cell free expression systems . As alternative membrane mimetics , I described in detail the structure of lipid nanodiscs by NMR , used them to reconstitute membrane proteins , and characterized membrane proteins in nanodiscs by label free single molecule mass photometry . During this time , I also got familiarized with cryo EM to investigate structures of amyloid fibrils and combined advanced biophysical and cell biology approaches to better understand the functions of the Parkinson s disease protein a Synuclein .. Technologies : Xray;CryoEM;NMR",proteins;expression;structure
"Principal Scientist . I build quantitative binding affinity models using machine learning . I scrutinize both the data and the predictions to find where the models are cheating ; with an eye to improving the methods , the metrics , and the data going forward . . I love solving problems where computers , code , data and machine learning meet . I have experience building and assess computational models that make predictions , especially about the future . I enjoy helping both the company and the team while constantly learning from everyone . . Technologies :",
"Cheminformatics Senior Scientist . . After spending the last few years of my education at UC Santa Cruz UCSC developing informatics tools for the analysis of high throughput screens in the Chemical Screening Center , I joined the Small Molecule Discovery Center in 2010 as a conduit between the three QB3 universities : UC San Francisco , UC Santa Cruz , and UC Berkeley . With my knowledge of the UCSC workflow and the essential technologies required , I am developing and integrating software promoting collaboration between the universities . Technology Specialties : Java , Groovy Grails , MySQL , JavaScript jQuery , HTML CSS , R , JFreeChart , D3.js , Spring , Hibernate , Chemistry Development Kit Software Specialties : Pipeline Pilot , Mathematica , PyMOL , Vortex , Cambridge Soft Desktop Software . Technologies :",
"Senior Scientist antigen mAbs process development . Department of VMRD Veterinary Medical Research and Development . Senior Scientist in a BSL2 BSL3 full GMP disposable pilot plant . . Process development and optimization R D for the transfer or improvement of manufacturing processes GMP ; viral antigen and mAbs production . Supervision of commercial , pilot and technical batches . Cell culture Viral production : use of rocking and agitating bioreactors for small scale production single use bioreactor of 250L and 1000L. Disposable systems used for clarification , inactivation , Xflow and dispensing . Monoclonal antibodies : cell culture purification filtration , chromatography , ultrafiltration diafiltration . Day to day follow up of the facilities GMP R D lab in collaboration with different departments QA , engineering , EHS , QC , . ; cleaning , validation , equipments , . Project management : interaction with internal Regulatory Affairs , Clinical Trials , . and external technology raw materials suppliers partners . Bioengineer in chemistry and bioindustries graduated in 2010 . 10 years of experience in the pharmaceutical industry . 8 years of experience in cell culture viral antigen production R D GMP Upstream Downstream . 3 years of experience in monoclonal antibody production R D GMP Upstream Downstream . Yellow Belt Lean Six Sigma . Upstream : . Adherent and suspension cells . Cell culture in disposable bioreactors from 2L to 1000L . Process development and optimization . Downstream : . Disposable inactivation , clarification and Xflow experience . Hollow fiber : process optimization . Purification of mAbs filtration , chromatography , viral clearance , UF DF . Technologies :",antibodies;expression
Scientist Researcher . PhD scholar at University of Glasgow and University of Edinburgh funded by MRC Precision Medicine scholarship . . Bioinformatics researcher Competent and experienced DNA and RNA sequence data analyst .. Technologies :,
"Associate Director Business Development DACH . Integrated drug discovery solutions Biophysics : protein X ray crystallography , Cryo EM , Proteoplex , protein production , NMR , native mass spectrometry , Biacore , ITC , MST , DLS Chemistry : custom synthesis , medicinal chemistry , process chemistry Screening : covalent , non covalent fragment screening by NMR , mass spectrometry , DNA encoded libraries . . Technologies : Xray;CryoEM;ITC;SLS DLS;MST;NMR",proteins;small molecules;characterization;interaction;screening;structure
"Senior Scientist . I 'm a scientist working at the New York Structural Biology Center doing contract work for the Department of Defense . . Michael is a results driven scientist with more than 10 years of experience in structural biology , protein crystallography , protein biochemistry , and molecular biology research . As a doctoral student at Stony Brook University , his great desire to understand protein molecule function initiated interest in the exceptionally precise technique macromolecular crystallography . Michael s great desire to learn and continuously improve guided him through a productive period in graduate school where , utilizing macromolecular crystallography as the core technique , he developed a profound scientific intellect . The biochemical and structural analysis during his doctoral thesis demonstrated a unique evolutionary relationship between the pathways for molybdenum cofactor biosynthesis and ubiquitin dependent protein degradation . This effort provided novel insights into evolution . Furthermore , as a postdoctoral fellow at Columbia University , Michael s tenacious determination to find answers to complex scientific questions spearheaded the biochemical and structural investigation of the extremely important AMP activated protein kinase . This work was a key contribution in the drug discovery process for diseases such as cancer and diabetes . Throughout his career Michael has demonstrated a sharp scientific aptitude leading to numerous publications in peer reviewed journals including Nature . In addition , as a team spirited collaborator who deeply appreciates the unique qualities of each person , Michael has an enormous capacity for bringing people together to work productively . This characteristic has been essential for building dynamic collaborations throughout his career . Specialties : MOLECULAR BIOLOGY : subcloning , engineering expression vectors . BIOCHEMISTRY : protein engineering , enzymology , chromatography , mass spectrometry , fluorescence , light scattering , isothermal titration calorimetry . STRUCTURAL BIOLOGY : extensive experience in all aspects of macromolecular crystallography . COMPUTER SKILLS : Linux UNIX , Windows , crystallography software , Vector NTI , Modeller homology modeling , Autodock ligand docking , Threader threading , office and graphics software .. Technologies : Xray;ITC;SLS DLS",
"Senior Director , Biological Sciences . . Protein biochemist with expertise in biochemical biophysical characterization of complex drug discovery targets .. Technologies : CryoEM;SPR;NMR",proteins;small molecules;characterization
Senior Research Bioinformaticist . . . Technologies :,
"Scientist . Work with protein biophysics and assay development to screen small molecules in early phase drug discovery . Work includes involvement in target identification , validation and hit discovery , such as high throughput screening , as well as hit to lead . The small molecules are primarily designed to inhibit protein protein interactions or to direct protein degradation PROTACs , in research centered around inflammatory immunological disorders . . PhD in biochemistry with a primary expertise in protein protein interactions , studied by biochemical and biophysical methods . Prior to the PhD studies I engaged in one academic and one academic industrial project at the side of , and after , the MSc studies , involving work with analytical biochemistry and bioreactors . Additionally , a one year MSc thesis project was pursued in the field of mammalian cell biology in relation to neuroinflammation . This work has led to publications in three different fields . A display of project management and leadership skills , together with expertise in protein biochemistry , can be seen by my conception of a pressing research question , design of research plan and the delegation of responsibilities to team members , which resulted in a prestigious publication in PNAS . As a person who values collaboration skills and interdisciplinary collaborations highly , reaching out to internal or external colleagues with different expertise to seize opportunities is very exciting to me . One example being an initiative to reach out to a foreign professor to pitch an important research question I had conceived , designed the research plan for and subsequently acquired two short term fellowship grants from EMBO and the Parkinson 's foundation . I also have proficient communication skills ranging from laymen to expert audience , which includes a presentation to 100 international experts at a conference as well as an invited 45 min layman presentation , both of which were very well received . My colleagues typically describe me as a creative person who plans his experiments carefully with an ability of asking the right questions and solving challenging problems in an autonomous fashion . In addition , I am considered easy going and a good collaboration partner , albeit one who can be direct and clear in case a project needs to be discussed . Thanks for visiting my profile and do n't hesitate to contact me with any questions at tony werner outlook.com .. Technologies :",molecular glues;proteins;small molecules;interaction;screening
"Senior Scientist . . Scientist with special interest in membrane proteins such as GPCRs and ion channels which are targets for pharmaceutical drugs . More than 10 years experience in both academia and industry have made me especially competent in project management , experiment design , data analysis , presenting results to scientific audiences , customers and partners , networking and creative problem solving I have hands on experience in techniques within the fields of protein biochemistry , molecular and cell biology : bacterial and human cell cultures , cloning , recombinant protein expression and purification affinity chromatography , gel filtration chromatography , FPLC and HPLC systems , reconstitution of membrane proteins into nanoparticles , in vivo and in vitro cell and protein assays , Western Blot , SDS PAGE , RT PCR , ELISA As a person , I consider myself efficient , organized , fast learner and proactive . I enjoy interacting with colleagues , customers and collaborators and my colleagues describe me as helpful , creative and easy to approach . Contact me : pilarlloris gmail.com or 0707668283 . Technologies :",membrane proteins;characterization
"Clinical Research Scientist . . Adaptable scientist with extensive laboratory , clinical , and programming experience . Strong data and bench research skills with a passion for leveraging data and machine learning to solve some of the most challenging diseases . Natural project manager known for effectively leading collaborations both internally and externally . CAREER HIGHLIGHTS Software Development Deployment : Blend biomedical and programming expertise by developing programs and web applications to address high 35.6 error rate in the organ transplant compatibility database . Lead projects through production deployment . Completed first project from scratch in 6 months . Transplantation Immunology : Developed and validated standard operating protocols SOPs for several new diagnostic tests for transplant patients that became standard of care : flow cytometry crossmatch for patients organ matching , Luminex antibody assays . Government Relations : Composed proposal for adoption of new diagnostic test SOPs as standard of care . Skills Core Competencies : Project Management Analysis Clinical Research Statistical Analysis Experimental Methods Wet Lab Biology Immunology Computational Skills : Unix , Python , R , HTML , CSS , JavaScript , Django , RESTful API , Swagger , Wordpress , Amazon webservices EC2 , LINUX , cloud based systems , high dimensional data . Technologies :",
"Leader , Dioscuri Centre for Physics and Chemistry of Bacteria . . I am a researcher in statistical biological physics . I apply theory , simulations , and experiments to problems of biological evolution such as the evolution of antibiotic resistance , adaptation in growing microbial colonies , the evolution of metabolic networks , and universal properties of fitness landscapes . Besides research , I am passionate about computer programming and computer graphics . As a teenager I would write computer games and then play them . Sadly , I do not have time for this any more . However , I often combine my scientific programming skills with 3d programming to create realistic visualisations of my computer models . I also like to work at the software hardware interface , programming microcontrollers that control my microbial evolution experiments .. Technologies :",
"Head of Bioinformatics Genetics . . I am an expert data scientist with a background in pharmacy and bioinformatics , and a PhD in computer science . My areas of expertise are machine learning , data mining , next generation sequencing , computational biology and bioinformatics .. Technologies :",
"Vice President , Head of AI Development . . I am an experienced artificial intelligence machine learning , data science , data management and scientific software development team leader with a wealth of experience in the pharmaceuticals industry . I have strong information technology background with hands on expertise in cheminformatics , artificial intelligence machine learning , data management , and software development .. Technologies :",
. . . Technologies : CryoEM,idps;structure
". . 3D reconstructions of macromolecular complex , viruses , cellular architectures by cryo electron microscopy cryoEM cryo electron tomography CET computer assisted image analysis . Purification of membrane protein ; Material science metal ceramic composites , nanomaterials , semiconductor multilayer thin films ; Fatigue behaviors of Materials ; Microstructural characterization by TEM SEM AFM X ray diffraction , etc . Goals : To probe scientific question in depth and make myself contribution in research application Specialties : Biostructure , Biophysics , Biochemistry , Cryo EM Cryo ET Material Science , Fatigue , TEM SEM AFM X ray . Technologies : Xray;CryoEM",membrane proteins;structure
"Permanent Staff and Laboratory Manager . . I am a structural biochemist with a PhD in applied biosciences and did my habilitation in microbiology . I work on different protein complexes and try by high resolution methods including electron cryo microscopy , X ray crystallography , biochemistry , nanotechnology and other cutting edge technologies to determine their structure . A special attention lies on the biological energy conservation , analysis of membrane protein complexes , and conformational dynamics , which is subject to their function .. Technologies : Xray",proteins;structure
"Chemist . I work on the high throughput chemistry team assembling libraries of molecules to be screened for activity against clinically relevant targets , averaging up to 18,000 new compounds per week by using an integrated Access Echo system . Additionally , I am onboarding palladium coupling chemistry to the platform , which entails condition scouting , LC MS , and performing toxicity interference assays . . I am passionate about biology , chemistry , and computer science ; I intend to use knowledge of these subjects to one day contribute to climate change solutions or medicine . In the future I would like to learn more about business so that I can combine my love of science with my interest in nonprofits .. Technologies :",small molecules;developing;screening
Postdoctoral Researcher Risk prediction of cardiovascular events . Joint postdoc between the German Heart Center and the Helmholtz Center . Working on risk prediction of cardiovascular events using clinical and bioinformatics data . . . Technologies : CryoEM,
". . Ph.D. candidate in structural biology mainly focus on membrane protein . Used to work on nanomedicine drug delivery system . A researcher with strong social ability , excellent teamwork skills , and good leadership .. Technologies :",membrane proteins;structure
"Associate Director Antibody Science . Operations and Resource manager , Antibody Science department . . . Technologies :",antibodies;developing
Atmospheric Support Scientist . . . Technologies :,
"Clinical Research Scientist , Medical . . I am a focused and passionate drug discovery and development scientist scientific project manager with 10 years of experience from the pharmaceutical industry . I have solid experience within drug discovery all the way from in vitro assay development to clinical development . I have a firm track record of experience with design , scientific management and conduct of clinical studies . I have designed and written protocols for MAD , PET direct 11C labelling and combined EEG occupancy studies , AME , cocktail DDI , CYP induction , and several PK studies for the clinical investigation of a number of small molecules and biologics drug candidates within several CNS indication spaces testing both experimental drugs and approved compounds .. Technologies :",
Principal Scientist . . . Technologies :,
Bioinformatics Scientist . Design algorithms for early biomarker based cancer detection . Biomedical data scientist and mathematical puzzle solver . Helping others to learn along with me . Github : https : github.com mikegloudemans Google Scholar : https : scholar.google.com citations user SROQ378AAAAJ . Technologies :,
"Principal Scientist II . Delivered high quality target proteins cytosolic , membrane , oligomeric , secreted , and multi subunit complexes to multiple small molecule inhibitor and targeted protein degradation projects and enabled in vitro biochemical assays and structure determination by X ray crystallography , NMR and cryo EM Carried out biophysical assays DLS , DSF , BLI , and ITC to characterize drug interactions and analyzed the target protein conformations by negative staining EM . Being trained for cryo EM data processing within the NIBR cryo EM group Strongly collaborated with scientists across multiple disease functional areas in NIBR and with external partners in industry and scientifically contributed to various projects as a core team member Led structural biology and protein science sub teams in several drug discovery projects . Hired and managed people as a lab head direct reports and interns and mentored a postdoc for successful characterization of membrane protein NS4B with NITD 688 Served as a NIBR diversity and inclusion D I activator to promote psychological safety and D I culture at workplace . Protein scientist with deep structural biology backgrounds and extensive experiences of drug discovery research . Inspired to unravel critical biological questions with multidisciplinary approaches and curious to identity the best possible way of protein inhibition or activation . Impacted multiple drug discovery projects through strong scientific achievements and collaborations . Served as a diversity and inclusion activator to unleash the power of people . Overall , wish to grow as a drug discovery catalyst by providing the best strategy and bridging cross functional collaborations in the inclusive culture .. Technologies : Xray;CryoEM;ITC;SLS DLS;BLI;DSF;NMR",proteins;small molecules;characterization;interaction;structure
"Assistant Professor . I am interested in membrane protein structures and lipid protein interactions . I am interested in utilizing different approaches in electron microscopy to probe the structures of biological membranes . My research group initially focus on the structural studies of the receptor complexes that are associated with neurodegeneration and dementia . In parallel , I am also developing new methods to improve the cryo EM methods , such as sample preparation , new imaging method , and image classification . . My research interest focuses on mechanistic studies of biomacromolecules , membrane lipid protein interactions , and cryo EM method development . My laboratory currently focuses on structural studies of membrane receptor complexes of neurotrophins and the mechanism of p97 mediated membrane fusion . In parallel , we are developing a new method to minimize the air water interface problem in cryo EM sample preparation and exploring electron holographic imaging for biological cryo EM . We are also collaborating with other scientific labs to explore cryo EM use in various fields .. Technologies : CryoEM",membrane proteins;interaction;structure
"Postdoctoral Fellow . Investigating cancer onset within a healthy epithelium using organoid 3D cell culture systems and multimodal imaging . In situ structural cell biology studies . Cryo electron tomography , subtomogram averaging , cryo FIB SEM , cryo liftout , FIB SEM tomography , high pressure freezing of multicellular specimens , Brillouin microscopy , CLEM . . PhD in biophysics with background as Biopharmaceutical Scientist with international research experience academic and industrial . Strongly interested in brain tumours research field . I am open minded for any new and innovative approach to target cancer and greatly appreciate discussions about ongoing and future projects . Specializations : Structural Biology Biophysics Nanotechnology CryoEM Image Processing Organoids . Technologies : CryoEM",proteins;structure
"Computational Biologist . . Experienced Bioinformatics Scientist with a demonstrated history of working in the healthcare , higher education , and research laboratories . Skilled in data analysis , data visualization , databases , R , Python , web tool development , and algorithms . Strong research professional with a Master 's Degree of Computer Science focused in bioinformatics . . Technologies :",
"Principal Scientist I in Translational Modeling Simulation . . Currently a Principal Scientist I in the Translational Modeling Simulation group at the Novartis Institutes for BioMedical Research NIBR in Cambridge , MA . I obtained my BS in Biomedical Engineering from Drexel University in 2016 , and then my PhD in the Biomedical Sciences from the Icahn School of Medicine at Mount Sinai in 2021 . As a doctoral candidate , I was a member of the Sobie Lab where I utilized cardiac electrophysiology mathematical models and machine learning techniques to study arrhythmia susceptibility in different patient populations . Now as a scientist at NIBR , I am applying my doctoral research to advance the company s predictive cardiac safety efforts . Technical : machine learning , regression , classification , clustering , ordinary differential equation modeling Computer : Python scikit learn , pandas , matplotlib , R Programming shiny , MATLAB SimBiology GUI Compiler , git , GitHub . Technologies :",
"Senior Scientist . . Senior Scientist in Philips Research Labs designing novel clinical informatics solutions for oncology and cardiology through ideation , prototyping , clinical validation and productization . Currently focused on oncology pathways , longitudinal treatment patterns , similar patients analysis , clinical trial matching and quality metrics analytics . Past experience in clinical informatics and bioinformatics encompassing : development of data aggregation and analytics platform for learning patient treatment data comprising clinical , medical imaging DICOM and physician report data from radiation therapy oncology designing network graph algorithms and novel computational methodologies to study and analyze biological high throughput data sets of RNA seq data . graph theoretical algorithms and probabilistic statistical modeling for detecting patterns of regulation , significant targets , biomarkers in miRNA gene networks in cancerous diseases . Technologies :",
"Scientific Coworker . Scientific Coworker . Xiaochun Li Blatter has worked at Biozentrum , University of Basel for 23 years . Together with Professor Anna Seelig and Professor Joachim Seelig , she has successfully worked on many different projects , including quantitatively evaluated the mechanism of activation and inhibition of ATP binding cassette transporters P glycoprotein , SAV1866 , BCRP and contributed to the drug formulation strategies to overcome the multidrug resistance problems . Later she has also worked at Biophysics Facility of Biozentrum with Dr. Timothy Sharpe , to teach and train students and researchers a series of biophysical techniques , especially protein ligand binding assays , help them applying these methods to their own projects . She has published 21 publications . Currently she holds a position at Structural Biology , Biozentrum with Professor Camilo Perez . Her work mainly focuses on the following fields : . 1 . Intensively investigating the physicochemical properties of drug surfactants lipids polymers peptides proteins and studying their binding passive diffusion to lipid membranes . 2 . Characterization of biomolecules e. g. drugs and proteins antibodies and nanoparticles with respect to size , charges , conformation , stability and oligomeric states . 3 . Determination of binding constants and stoichiometry of interactions of macromolecules liposomes , proteins antibodies and polymer particles and ligands drugs , surfactants , peptides and other biomolecules . Characterization of the interactions with thermodynamic parameters to understand the binding mechanism and kinetics at the molecular level . 4 . Developing high through put screening techniques for inhibitors substrates of membrane transporters and quantifying their potency . 5 . Establishing plate reader based assays for enzyme kinetics and binding studies . The main research tools : . isothermal titration calorimetry , differential scanning calorimetry ; dynamic light scattering , zeta potential measurement ; microscale thermophoresis ; surface plasmon resonance ; surface pressure measurement ; fluorescence based thermal shift ; UV Vis , fluorescence and circular dichroism spectroscopy , plate reader based high throughput screening techniques . Her knowledges and kills are suitable for membrane transporter study , drug development , therapeutic protein analysis , high throughput enzyme kinetics and binding study . https : www . researchgate . net profile Xiaochun Li Blatter research . Technologies : ITC;SLS DLS;DSC;SPR;MST;CD",antibodies;carriers;membrane proteins;peptides;proteins;small molecules;characterization;interaction;screening;structure
Bioinformatician . . . Technologies :,
"Birmingham Fellow . Joined the University of Birmingham in 2013 to establish an independent research group . Research is focused on investigating how plants use targeted protein degradation as a mechanism for sensing and responding to developmental and environmental signals , and how this coordinates growth , development and stress response . . A research scientist who is interested in understanding the molecular mechanisms that plants have evolved for sensing and responding to diverse developmental and environmental signals , with a particular focus on targeted protein degradation as a system for signal perception and transduction . The general aim of my research is to increase our understanding of how plants develop and respond to the environment , and to identify promising targets that can be manipulated in agriculturally important crops to improve growth , productivity and stress tolerance . As weather patterns become more unpredictable due to climate change , a comprehensive understanding of how plants grow , develop and cope with stressful situations such as drought or flooding is essential if we are to develop crops that can sustain a growing global population .. Technologies :",molecular glues;interaction
Graduate Student . . I am an aspiring structural biologist looking to challenge myself in the next phase of my education . My skill set is heavily revolved around protein biochemistry . Currently my research focuses on understanding the mechanistic details of molecular chaperones and disaggregases through cryo electron microscopy .. Technologies : CryoEM,proteins;structure
"Scientist , postdoc mentor . . Highly experienced structural biologist interested in membrane protein structure and function Proven success with challenging membrane protein structure determination with Cryo EM and X ray crystallography Dedicated biochemist and biophysicist . Technologies : Xray;CryoEM",membrane proteins;structure
"EM Academic . . EM Academic at AJ Vaccines Environmental monitoring Microbiology Validation of aseptic environment Validation of aseptic behavior Deviation handling Graduated with a M.Sc . degree in Biochemistry from University of Copenhagen with the grade 12 . Completed my thesis at Novo Nordisk Foundation Center for Protein Research . Worked with CRISPR associated proteins to understand their structure and mechanisms in the Montoya Group . Experience in structural and biochemical protein research : In fusion and USER cloning Recombinant protein expression Protein purification using kta chromatography systems and BioRad Prep Cell Protein X ray Crystallization Cryo Electron Microscopy In vitro activity assays Experience in Quality Assurance : Worked with GMP and ISO 9000 , completed GMP training at Xellia Phamaceuticals Surveillance of aseptic behavior during media fill validation finished dosage form Completed training in contamination control and aseptic behavior Handling of stability samples , analysis requisitions , data entry , log and archiving samples Sample handling in LIMS software Worked on a large GMP archive project , streamlining archiving of GMP batch documatation . Technologies : Xray;CryoEM",proteins;expression;quality;structure
"Lead Project Scientist . . I am a lead bioinformatics scientist working on scalable methods for discovering new small molecule drugs . I have long standing experience in developing cutting edge metabolomics and meta genomics platforms for discovering small molecule anti infective , anti cancer , and other medicinal compounds that exist in nature natural product . Our methods rely on concepts from artificial intelligence , machine learning , and combinatorial algorithms and integrate the power of Omics sequencing for high throughput drug discovery . I believe that we are at a dawn of a new frontier in drug discovery .. Technologies :",
"Turing Fellow Computational Biology . Postdoctoral Fellowship from the National Biosciences Institute NBI and Alan Turing Institute ATI , to train in machine learning and artificial intelligence approaches , and their application to life sciences . Stonewall Representative on the Inclusivity and Diversity Committee . . In February 2021 , I was awarded a Postdoctoral Fellowship from the National Biosciences Institute NBI and Alan Turing Institute ATI . The fellowship aims to train scientists in machine learning and artificial intelligence approaches , and their application to life sciences . I m working with the BRAVO project at the John Innes Centre to understand how phenotypic changes , such as branching and pod size , are genetically regulated during development in Brassicas . . Technologies :",
"Scientific Associate . My work in NIBR consists in the production , the purification and the crystallisation of integral membrane proteins in the Chemical Biology and Therapeutics former Center for Proteomic Chemistry for research purposes . This includes generating the expression vectors baculovirus systems in insect cells to the characterization of the proteins , which are used for crystallisation screenings and binding assays . My technical skills in protein expression embrace baculovirus expression vectors generation FlashBac transfection systems , amplification , small and medium scale production of modified integral membrane proteins in insect cells Sf9 cells . I am responsible for maintening and expanding of the insect cell lines , as well as the baculovirus infections and cell harvesting . I also generate mammalian stable cells lines , using the Jump In T Rex system . I set up and use a cell surface expression assay to control the quantity and quality of the recombinant proteins , involving the use of FACS GUAVA instruments . Responsible for the purification of proteins , I strengthen my experience in affinity chromatography IMAC and in Size Exclusion Chromatography . I gained new technical skills in the purification of membrane proteins . Protein characterisation work involves SDS PAGE , Western Blots chemioluminescence , SEC MALS , Differential Scanning Fluorimetry and Mass Spectrometry . I developed new experience in crystallization of integral membrane proteins , mainly using Lipidic Cubic Phase . . Highly motivated scientist in protein science , antibodies and biotechnology working in a leading pharmaceutical company . Strong technical skills in molecular biology , in soluble and membrane protein production , purification and characterisation . Experience in cell assays , FACS , phage display and crystallization of membrane proteins . . Technologies : DSF",membrane proteins;proteins;characterization;expression;interaction;structure
"Scientific Director . . I am a highly skilled biochemist with extensive experience within pharmacology and different but related disciplines such as structural biology of membrane proteins , drug screening as well as cell biology . Thus I have a understanding of many parts of the process that goes into developing a new drug candidate . Thus I somewhat consider myself a jack of all trades in this context . I know people consider me to be very pragmatic and have a long term strategic mindset . I am good at optimizing processes and projects from a cost benefit point of view . In a new organization I will based on my wide experience and critical thinking usually be able to suggest potential new ways to organize the workflow and physical settings . I like to present data and discuss strategies and to work in a larger organization with many stakeholders . I have during the last 10 years worked in some of the world leading laboratories Brian Kobilka , Stanford and Beili Wu , SIMM within GPCR structural biology as well as at Novo Nordisk . And I have because of this lived several years abroad in the USA and China . And since I have experienced different ways of life I try to keeps my eyes open to different ways of doing things . . Technologies :",membrane proteins;structure
"Senior Principal Scientist . Leverage multi omics analysis to discover new therapeutic targets in the tumor microenvironment . Analyze clinical trial data , real world data , and public databases of genomics data to provide MOA validation , biomarker discovery , and patient stratification for preclinical drug discovery programs . Recruit and manage CROs and contractors to develop single cell workflows and analysis tools . . Thrilled to work at the interface of computational and experimental life science . Enjoy learning domain knowledge , developing assays , building data infrastructure , developing statistical and machine learning analysis , and deducing biological meaning of results . 20 years of hands on research experience in both computational and experimental biology ; 10 years of management and mentoring experience ; 27 peer reviewed publications .. Technologies :",
"Lead Bioinformatician . I joined Nucleome to build and lead the computational team of bioinformaticians and machine learning researchers to contribute to the mission of discovering novel disease treatments by unveiling the unknown secrets of the less studied dark matter of the human genome , i.e. the non coding DNA . . A leader embedded in the development , integration , and application of the next generation of bioinformatics , machine learning , and data science to facilitate leveraging multiomic and clinical data e.g. genomics to discover new drugs , unveil the secrets of genetics , and improve the healthcare system . A blend of London Oxford based experience in academia and industry at and beyond the forefront of human knowledge . Vision and objective focused while designing computational analyses in the context of the underpinning biology . On my priorities is to educate enthusiastic people on bioinformatics and clinical data science .. Technologies :",
Senior Bioinformatics Data Scientist . Department of Data Science . Bioinformatics Data Scientist specialized in processing and developing pipelines to interpret BIG data . Technologies :,
"PhD Student . Department of Structural Biology W. K hlbrandt Project : Structural Characterization of Membrane Proteins by Cryo EM . I am a scientist , fascinated of the immense diversity and power of the tiniest engines of living cells . For visualization and understanding of these engines especially those sitting in the membrane I use electron cryo microscopy combined with a large variety of biophysical and biochemical methods . I like tackling challenging problems , trying out new and innovative approaches and I enjoy and thrive on discussing and sharing knowledge with my colleagues .. Technologies : CryoEM",membrane proteins;proteins;characterization;structure
"Research Scientist . . Full experiences on Cryo EM single particle protein structure determination , including cryo grids preparation , data collection , data processing , high resolution structure determination , and model building . Deep understanding and 3 years experiences on X ray crystallography and structure determination ; Strong background knowledge and experience on molecular cloning , protein expression in bacterial and yeast platform , protein purification and characterization ; Extensive experience in electron microscopy , vitro blot , and related hardware handling and maintenance ; Proficient in large data set processing with the high performance computer , software environment setup and maintenance , and basic shell script and C programming . . Technologies : Xray;CryoEM",proteins;characterization;structure
"Postdoctoral Research Scientist . Institute of Physiology and Pathophysiology . Assay development in primary smooth muscle cells , 3D cellular spheroids or isolated blood vessels ; construction and use of adenoviral and AAV vectors . Supervision of technical staff , writing SOPs . Instructor of practical courses in human physiology for medical and dentistry students . I 'm an experimental pharmacologist with research experience in the field of vascular and adipose tissue biology . The focus of my research is on understanding the patho physiological role of intracellular communication in relevant models primary cells , 3D spheroids , or isolated murine tissues in order to identify therapeutic targets . My research projects thus far have revolved largely around the analysis of RTK and GPCR activated pathways , and are more recently focusing on heterotrimeric G proteins their endogenous regulators . Over the years , I have learnt to logically apply pharmacological or genetic tools to address given experimental questions and have gained experience in developing cell or spheroid based biological assays for target identification , validation or small molecule screenings . Apart from the technical knowhows in the field of cell molecular biology , exposure to different work environments have expanded my skills in project management , cross cultural communication , supervision of technical staff , scientific writing , data analysis presentation , building nurturing new collaborations and efficient working in matrix structures . On a personal note , I love to spend free time with family usually outdoors . I am interested in challenging roles to identify targets biomarkers and or discover therapeutics not only limited to small molecules but also other modalities such as biologics , gene or cell therapies for diseases with unmet medical needs . Feel free to reach out for networking , opportunities or discussing ideas . Technologies :",carriers;small molecules;characterization;screening
"Staff Scientist . Cryo EM image processing and analysis in a core facility . . Biochemist and structural biologist , currently doing cryo EM .. Technologies : CryoEM",proteins;structure
Senior Principal Scientist . . Management experience in biotech and small molecule drug discovery and development . Currently leading projects to discover new antivirals . Previous efforts : development of antivirals for treatment of HIV and HCV and antibiotic discovery . . Technologies :,small molecules
Computational Scientist . . . Technologies :,
"Student . . Doctor of Medical Science with expertise in Medical Biochemistry and cell and molecular biology , protein chemistry . I am a motivated and enthusiastic research scientist with strong publication track record and teaching experience . I am organized , task oriented and able to work independently . I am also a team player and my colleagues find me socially amicable . I possess strong interpersonal communication skills and have been working in research projects within academia for 10 years mainly in Sweden . I am open for new opportunities within life sciences sector that would foster my career goals and provide an opportunity to strengthen my skills . Skills : Project Management , Scientific Communication , Teacher , Interpersonal and Managerial skills . Analysis : Multivariate analysis and Univariate analysis Cloning , Recombinant protein expression and purification , Cryo EM Biomolecular characterization of protein protein and ribonucleoprotein complexes . Assay development , Virus detection Expert in the field of mucosal biology , molecular immunology , Keywords : Mucins , Mucosa , molecular Immunology , proteases , H. pylori , S. oralis , Biochemistry , Structural biology , Nucleic acid detection , Fermentation . Technologies : CryoEM",nucleic acids;proteins;characterization;expression;interaction;structure
Scientific Manager . . A structural biologist with research experiences focusing on mechanistic insights using cryo EM workflows for 9 years to solve structures and validate challenging membrane associated complexes . Acumen with managing highly collaborative multicomponent research endeavors resulting in high impact journal publications and successful acquisition of grant funding .. Technologies : CryoEM,proteins;structure
"Bioinformatics Analyst . Key contributor to the National Bacterial Viral Bioinformatics Resource Center Led product development through functional specification , project design , data sourcing , implementation , and testing in collaboration with engineers Developed new algorithms and custom Python library which expedited computational research Designed and delivered 24 user training workshops worldwide , and expanded user base 6x Performed computational research on viral pathogens , presented at 11 international conferences , and co authored 16 peer reviewed and 3 invited articles Mentored summer interns providing support in project design , coding , and writing . Results driven , user focused computer science graduate with solid training in computer systems Five years programming experience in Java , Python , JavaScript , jQuery , PHP , SQL , C , C Six years experience in full software development lifecycle from concept through delivery Experienced in full stack , desktop , and mobile app development . Technologies :",
"Head of Bioinformatics . . Executive and entrepreneur in genomics with 20 years of experience , with the goal of making clinical genomics easier , more useful , and more widely used . I specialize in the development of computational methods , but am driven by deeply understanding the molecular biology that drives all discovery . Most of my experience is in cancer , but I am interested all applications of genomics in biology . In the past decade I have worked on CLIA whole genome and whole transcriptome sequencing from FFPE and blood , fragmentomics of blood plasma and urine cell free DNA . My computational efforts include probabilistic graphical models for integration of multi omic cancer data with pathway signaling , and I have lead a research team using deep learning on sequence analysis as well as and cancer histopathology images .. Technologies :",
"Ing nieure de recherche . . I am a specialist in cell biology , biochemistry using cryo electron microscopy to answer my scientific questions . I have a Ph.D. in Life Science from University of Bordeaux then I did my postdoctoral training at Cornell university Ithaca , NY , USA and in I2BC Gif sur Yvette , France . All along my scientific career , I used molecular and cell biology approaches coupled with biochemistry , biophysics and with photonic and electron microscopy to answer biological questions leading me to explore cryo electron microscopy . I am currently working at the Institute Pasteur Paris where I am developing techniques for in cellulo Cryo Tomography from cell culture to Cryo Correlative Light and Electron Microscopy and reconstruction in different biological systems .. Technologies : CryoEM",structure
"Senior Scientist , Biotherapeutics Lead Discovery . Codexis is a leading enzyme engineering company with 250 people and growing working to enable the promise of synthetic biology using its proprietary engineering platform CodeEvolver to evolve biotherapeutic enzymes . I joined the Biotherapeutics Lead Discovery group as a project team leader and key scientific leader , and work on high level and day to day strategy as well as bench work and team management . My focus has been on revitalizing a gastrointestinal disease project that stalled during the pandemic , as well as working on strategies for new projects and partnerships with other drug companies . I spend 30 of my time in the lab running critical experiments and troubleshooting for other projects , as well as working on recruiting talent directly in a challenging hiring market . . I m a senior scientist who drives research in protein biochemistry for drug discovery . A collaborative leader and teammate from ideation to endpoint , I develop and optimize biochemical , biophysical , and molecular biology assays and testing molecules and plan experiments to research protein engineering and assay development to support drug discovery efforts . I joined the enzyme engineering leader Codexis in March 2021 to be a project team leader and key scientific leader for the Biotherapeutics Lead Discovery group , where I m leading revitalization of a GI disease project and working on new growth strategies for our pipeline and partnerships . Prior , I spent five years focusing on infectious disease at the R D center of The Janssen Pharmaceutical Companies of Johnson Johnson , where I helped build a new team after the exit of key scientists . Working on multiple projects concurrently , I was a bench scientist , conducted experimental research , and presented data to our teams in Shanghai , Belgium and the East Coast . With 3 colleagues , I received the Vice President s Research Award for Outstanding Technical Achievement in 2020 for our RSV polymerase protein breakthrough , published in Cell . I came to J J when I was the first postdoc hired to work for the newly acquired Alios BioPharma team , where I published research articles and book chapters , worked on the activation of the clinical state RSV drug lumicitabine , and collaborated with the CDC on exploratory projects for insights about emerging RNA viruses . With a Ph.D. in Biochemistry from Montana State University and a B.A. in Biology and Chemistry from Bard College , I ve also completed courses in Cryo EM for drug discovery at Rutgers University ; Light Scattering University by Wyatt Technologies ; Johnson Johnson s leadership training , the SHINE Leadership Summit ; and in 2021 , From the Laboratory to Leadership program for leaders in life sciences from The Leadership Edge . I m always growing my network and interested in connecting , so please feel free to reach out if there is anything I can do for you . KEYWORDS biochemical and biophysical assays for drug discovery protein design and engineering molecular biology recombinant protein expression and purification high throughput assay development biotherapeutics lead discovery infectious disease drug discovery gastrointestinal disease drug discovery rare disease drug discovery enzymology automation and liquid handling enzymatic assays PhD scientist recruiting and mentorship cross functional team leadership . Technologies : CryoEM",biologics;enzymes;developing
"Predoctoral Fellow . During my predoctoral studies I am working on the characterization of a large protein complex involved in several RNA processing pathways . By employing a combination of cell culture based techniques and recombinant expression I want to gain insights into the composition of the complex and obtain a sample for cryo EM studies and biochemical assays to determine its mode of function . Applied techniques : Cell culture based o Stable cell line generation o Analytical Pull downs to identify direct interactors and novel subunit Recombinant Expression o Insect cell based co expression of up to 14 different subunits Molecular Cloning o Assembly of up to 14 different genes into one vector 52 kb for insect cell expression o Generation of a plasmid library which allows for quick exchange of tag combinations and expression systems mammalian cells insect cells Cryogenic Electron Microscopy o Grid preparation Vitribot , FEI o Data collection Glacios cryo TEM , FEI o Data processing Relion 3.0 , WARP Model building and refinement o Coot o CCPEM o EMAN Other techniques o Western blotting o PCR o RT PCR o Gradient ultracentrifugation o Affinity purification HPLC . . Technologies : CryoEM;AUC",proteins;interaction;structure
"Scientist . Membrane protein biochemist Discovery Protein Sciences Support the drug discovery pipeline through the delivery of critical membrane protein reagents . Optimize construct design and expression purification conditions for challenging membrane protein targets . Communicate across multifunctional and multidisciplinary teams to develop protein expression and purification strategies tailored to an array of downstream applications . . Membrane protein biochemist with an extensive background in ion channel structural biology . Strengths include membrane protein expression and purification , single particle cryo electron microscopy , x ray crystallography , and patch clamp electrophysiology . Also experienced in tech methods development across the membrane protein structure pipeline .. Technologies : Xray;CryoEM",membrane proteins;expression;structure
"Consultant for drug discovery . . Scientific research : Drug hunting from target discovery to IND siRNA , ASO , large and small molecules in different disease areas . Personalized medicine , diagnostic , PK PD biomarkers and translational science IHC , molecular assay , biochemical assays , immunoassays . Biomarker identification , validation , and clinical sample analysis , GLS and GCP . Experience and ability to learn and adapt to new areas . Innate immunity infection , inflammation , metabolism and gastrointestinal disorders visceral pain neurobiology . Molecular biology in vitro pharmacology : Target discovery , gene expression profiling , Assay development and validation , and drug screening GPCR , ion channel , protein kinase , protease and nuclear receptor , Protein expression and characterization . Line management : Vice President for preclinical drug discovery from target selection to IND Senior director for PD , PK and bioanalysis Team leader , and associate director Post doc supervisor Project management : Project leader for projects covering from early target validation to candidate drug delivery . . Technologies :",membrane proteins;nucleic acids;proteins;small molecules;characterization;screening
"Machine Learning and Computational Biology Lead Deverman Vector Engineering Group . Developed the Machine guided technologies Fit4Function and MultiFunction , which enable high quality function screening data and systematic multi trait AAV capsid engineering Named inventor on multiple pending patent applications Built and Agile lead a team of 4 6 computational scientists to serve 10s of data driven molecular biology cutting edge technology development projects run by 20 scientists spanning different areas of AAV capsid engineering Own 10 large , strategic and complex Machine Learning AAV engineering projects in collaboration with molecular biologists Strategic functional leadership : experimental design , management , data driven decisions , lab strategies and vision Full stack practical Machine Learning : modeling , auditing , debiasing , bias editing , system engineering , inference , reverse engineering , validation , ML compatible data design Full stack computational biology : bioinformatics , genomics , statistics , processing and analysis pipeline design , algorithmic design , prototyping , simulation Excel in non conventional value creating data analysis Favorite work quote : How does a project get to be a year behind schedule One day at a time . Described as Computational Shark and Data Detective . Living and breathing Machine learning for 15 years ; with a specialization in developing novel therapeutic oriented technologies . Skilled in : analysis and modeling of challenging biological datasets ; identification and exploitation of data biases ; creating generalizable Machine Learning modalities for biological sciences . Specialized in : machine learning and computational biology of protein and capsid engineering .. Technologies :",
Bioinformatician . . . Technologies :,
"Professional Research Assistant . Currently split between two labs here at CU , Boulder . I am working with cryo electron microscopy and single particle helical reconstruction of microtubules and DNA fibers . . I have a broad range of laboratory research experiences in the fields of microbiology , protein chemistry , molecular biology , and bioinformatics . For the last 14 years I have worked in Electron Microscopy . I work with purified microtubules and molecular motors , as well as other proteins , and DNA . We use cryo electron microscopy and 3D image acquisition or single particle , helical reconstruction techniques to determine the structure of these molecules . . Technologies : CryoEM",nucleic acids;proteins;structure
Principal Scientist . Recombinant protein production and analytical characterization for small molecule drug discovery and biologics . . . Technologies :,biologics;small molecules;characterization
Senior Vice President Research . . Catherine Ball is an executive and scientist with the mission to bring the benefits of genomics to people around the world .. Technologies :,
"Principal scientist . Principal Scientist , responsible and accountable for all synthetic effort and resource on a medchem project . Lead on site team of 5 synthetic chemists and 5 external contractors , problem solve issues with synthesis and purification and delivery of compounds . . Principal scientist at Leo Pharma . I am a highly motivated chemist , with thirty years experience within a global pharmaceutical company . Have a proven track record of problem solving and delivery on an array of projects and project management including external contract resource . I am an open , proactive , enthusiastic , approachable individual with effective communication skills . Have a wide range of expertise in the field of organic synthesis with excellent practical skills . In depth knowledge and experience in numerous chemical series , very strong track record of problem solving and delivery . Well organised and productive individual , extremely focused with an eye for detail and a pragmatic approach to resolving issues . Involvement in research across numerous biological mechanisms and pathways , resulting in being named as inventor or author on 30 patents and papers across a wide range of target classes : e.g. Urology 5 alpha reductase antagonsits , 5HT1a , Sex Health PE , SSNRis , Women 's Health Vasopresin V1a antagonists , Progesterone antagonists , Pain P2Xs , delta opiods and Regenerative Medicine ALK inhibitors along with synthetic papers and collaborations with partner lines Rapi , PDM . Also significant experience to topical and oral delivery within the beyond rule of 5 physchem property space particularly with recent drug modalities that target the ubiquitin proteosome pathway PROTACs . Specialties : Medicinal chemistry , Synthetic chemistry , Hit to lead , Team management , Project Synthetic Leadership , supervisory skills , managing external contractor resource , supervising mentoring , patent writing .. Technologies :",molecular glues;small molecules;developing;screening
". . Enthusiastic about science and drug discovery Positive mindset and attitude towards new ideas and people Eager to learn and develop new skills Core competencies strong scientific background in GPCR pharmacology , cell signaling and biochemistry broad experience in pre clinical drug discovery , having worked in cross disciplinary project teams with computational and medicinal chemists , in vitro and in vivo pharmacologists and biologists adept at planning , developing and executing experimental studies skilled at conducting thorough data analysis and effective data visualization ability to communicate results efficiently and present findings engagingly . Technologies :",
"Scientist . Managing laboratory technicians ; target discovery for renal adrenal diseases with a focus on adrenal control on blood pressure , metabolism and sodium potassium homeostasis via the renal adrenal crosstalk ; study the regulation of an anti aging gene on renal adrenal function ; mechanistic study on clinic samples of hypercalcemia ; explore novel mechanism underlying adrenal regeneration by single cell RNAseq ; human disease modeling and therapeutics for point mutation related endocrine tumor ; in vitro modelling of point mutation by CRISPR . . 12 years of research experience in target discovery , physiology and pathophysiology of cardiometabolic diseases , with a focus on diabetes , obesity and renal adrenal disease ; . In depth knowledge of G protein coupled receptor GPCR kinase pharmacology and biology ; . Well trained pharma experience in screening based early drug discovery focusing on small molecules biologicals and target identification MOA studies , discovered several hit compounds for lead optimization ; . Discovered several hit lead compounds and new targets for obesity diabetes ; . Solid background in in vivo ex vivo in vitro studies , evaluation of efficacy , PK PD and mode of action MoA of candidate compounds , human disease modeling , CRISPR genome editing screening , 3D organoids culture and human spheroids studies ; . Proven track record by publications in top journals including Nature medicine , Nature reviews , Cell metabolism and Endocrinology ; . Independently lead the project , supervise lab technicians , responsible for management of cross functional project activities ; Well organized and highly motivated by challenges , keen to basic and translational research for tackling human diseases . . Technologies :",membrane proteins;small molecules;screening
Senior Bioinformatics Scientist . Develop algorithms for companion cancer diagnostics . I am a bioinformatics scientist working in the health care industry developing computational methods for cancer diagnostics based on NGS data . Skilled in algorithm development with python . Strong research professional with a PhD in Computational Biology from Carnegie Mellon University .. Technologies :,
"Scientist Protein degraders platform . Senior Research Scientist with extensive experience in drug discovery research for small molecule and protein therapeutics . Expertise in cell biology , protein biochemistry and assay development supporting and advancing Oncology targets . Motivated research professional with strong problem solving and communication skills that thrives in a challenging environment . . Areas of expertise : . Biochemical and cell based assay development to support target advancement . ELISA , HTRF , FLIPR , Western blot , Alpha Screen , luciferase . E3 ubiquitin ligase biology targeted protein degradation . IPSC and Primary cell culture Isolation , characterization , transfection . RNAi and CRISPR gene silencing RTPCR , ddPCR . Expression , purification and functional characterization of proteins . Chromatography AKTA pure system . Senior Research Scientist with extensive experience in drug discovery research for small molecule and biologic therapeutics . Expertise in cell biology , protein biochemistry and assay development supporting and advancing neuroscience and oncology targets . Motivated research professional with strong problem solving and communication skills that thrives in a challenging environment .. Technologies :",molecular glues;proteins;small molecules;characterization;interaction;screening
"Application Specialist . Characterisation of key cell and gene therapy viral vectors such as AAVs , adenovirus , lipid nano particles and extra cellular vesicles using MiniTEM . Responsible and accountable for designing proof of concept POC projects for prospective MiniTEM clients . Responsible for the planning , coordinating and live demonstration of the microscope system hardware and software and application for experienced and new potential clients . Trained and responsible for the internal and external user training . Assist in system verification , supporting software and hardware development by performing user testing . The work is organised around teams , and agile methodologies are applied . Assist with the development of training materials and instructions for use . Subject matter expertise for support of existing prospective MiniTEM customers . Supporting Sales and marketing teams with a focus on MiniTEM : Customer collaborations , strategic customer relations , event support and development of application related marketing material . . Dynamic and passionate scientist with a deep interest in Life Sciences . More than ten years of experience in research spanning various fields in membrane protein biophysics , biochemistry and structural biology . My academic and industrial career in several multi cultural establishments has turned me into a competent and effective team player , excellent communicator , interpreting and presenting scientific data at different levels . My journey has given me valuable experience in project management , networking , data analysis and problem solving . I am a highly motivated , optimistic , driven and fast learner with attention to details . Ready for a new challenge in a stimulating environment .. Technologies : CryoEM",
"Principal Scientist . . Bioinformatics data science professional with background in computer science and 12 years of experience with various clinical and disease model omic datasets in academic and pharma industry settings . Expert in various programming languages , computational environments , and hardware platforms .. Technologies :",
"Senior Manager , GRA CMC Specialist . Early stage development ADCs and NCEs . Chemist by training ; PhD in biochemistry and biophysics . Overall , more than 10 years professional experience in both Global Regulatory Affairs and CMC ; in small , medium sized and big pharma companies ; broad and worldwide experience in clinical development , marketing authorization applications and life cycle management of biotechnology derived products NBEs , ADCs , vaccines and biosimilars with FDA , EMA and Asia focus .. Technologies :",antibodies;developing;quality
"Emerging Socket Technology Supply Chain R D Engineer . . Currently working as a supply chain engineer at Intel on product manufacturability , supplier technical management , and supply chain material analyses . Specifically , I support TIM and adhesive solutions and have experience driving development and qualification of materials from the pathfinding phase to full HVM ramp to enable Intel s thermal roadmap . I earned my Masters degree in Chemical Engineering at Arizona State University , focusing on high resolution cryo electron microscopy imaging of proteins , under the Fulton Fellowship . My undergraduate research focused on DNA microfluidics , where I won multiple AICHE awards and appearing as a principle investigator on an NSF Career Award . Specialties : manufacturability quality reliability of semiconductor sub materials , material characteristics and treatments , product optimization , lean manufacturing and packaging , biophysical and chemical fluid theory . Skills : JMP , Linux , C , Python , supplier and project management . . Technologies : CryoEM",
"Bioinformatics Scientist . . Highly skilled in next generation sequencing analysis , Python , and molecular biology . Experienced in software development , market analysis , and the healthcare industry .. Technologies :",
"Analytical Scientist . Development and validation of analytical methods for peptides and proteins Interdepartmental collaboration Collaboration with lab technicians Analysis for content and uniformity of dosage units UPLC Impurity analysis UPLC Size exclusion chromatography Documentation SOPs and validation reports Dissolution analysis for solid dosage formulation Stability studies Empower LIMS ChromSword software for automated UPLC HPLC method development . Analysis of solid dosage formulations with proteins Development and validation of analytical methods Documentation SOP , validation reports Dissolution experiments Stability studies LIMS and Empower ChromSword software for automated UPLC HPLC method development Cross collaboration laboratory technicians , interdisciplinary , interdepartmental Analysis of small molecules , peptides and proteins Peptide synthesis and characterization Fungal cultures and mycotoxin analysis DNA cloning , protein expression E. coli and cell free , protein purification and characterization Biophysical characterization techniques CORE PERSONAL SKILLS : Ambition , innovation , structure and maintaining an overview when multitasking . A dynamic environment stimulates my curiosity and ambition , and the scientific interaction with colleagues and continuous scientific development makes me thrive and fuels my dedication . I always embrace new challenges and it is important to me to meet deadlines and finish project tasks . Jung and Briggs Myers test : Clear ISTJ profile . Technologies :",peptides;proteins;characterization;expression;formulation;stability
"Graduate Student Researcher . Studying the aggregation of amyloid proteins in neurodegenerative diseases via cryogenic electron microscopy cryo EM and x ray crystallography ; performing rational design and validation of structure informed inhibitors . Thesis Adviser , Dr. David S. Eisenberg . I 'm interested in the structure function relationship of proteins and applying biophysical methods to elucidate their mechanisms of action . Structural determination is a powerful way to understand the molecular pathology of disease and can translate to the design of structure based therapeutics . My training is in protein biochemistry , x ray crystallography and cryo EM .. Technologies : Xray;CryoEM",idps;small molecules;interaction;structure
Bioinformatics Scientist . . . Technologies :,
"Senior CMC Specialist at VarmX . . February 2021 present : Senior CMC Specialist at VarmX. Responsible for managing CDMOs that manufacture our DS and DP . May 2018 October 2020 : Project Manager Senior specialist at Lundbeck . Responsible for analytical development in our global development projects with focus on the biologics projects . Managing CROs and evaluation new early phase projects . February 2016 to Maj 2018 : Director of clinical biochemistry and physiology laboratories including clinical research at Steno Diabetes Center . 2014 to 2015 : Associate Manager and Senior Project Manager , DFP BA , Business Support , PS , Novo Nordisk . 2012 to 2014 : Senior Project manager of a classified GLP 1 project , 17 project members in Denmark and Seattle , Novo Nordisk . Previously heading different teams in CMC , Novo Nordisk . The teams had focus on ELISA and cell based in vitro potency assays . The teams worked in a GMP and LEAN environment . Experience as Director in biotech company 7TM Pharma for 7 years . Areas in focus was Screening , Bioanalysis , biomarkers , in vivo and clinical trials . Evaluation of early phase projects , new targets . The indication pursued was Obesity . Experience as post.doc Edinburgh , UK with focus on 7TM receptors GPCRs signalling . Ph.D. project : Developing a new assay BIAcore for investigating insulin analogues binding kinetics to the insulin receptor . Specialties : Line management , project management , drug discovery , assay development , screening and GPCR pharmacology . Technologies :",biologics;membrane proteins;interaction
IRTA Postbac Fellow . Postbac Fellow in O'Shea Lab working with Dr. Danielle Chisolm . Graduated in Computational Biology Biological Sciences Sc . B with Honors I am involved in projects working towards the betterment of science communication and transparency . My current research interests in understanding the immune response to infectious diseases .. Technologies :,
"Postdoctoral Researcher at Department of Molecular Immunology . Working on understanding role of lipids in TCR activation and downstream signalling leading upto T cell activation . The tasks include but are not limited to Assay design and optimisation Small drug like molecule screening Functional assay developement to study protein protein interactions , protein lipid interaction . I am a scientist with experience in biochemistry and molecular immunology . As a PhD trained scientist , I am skilled at conceptualising and designing experiments , project management , data analysis , troubleshooting , documentation , and communicating scientific ideas through publications and presentations . Having spent almost a decade in an international environment in diverse teams , I have had the excellent opportunity to strengthen my empathic and people centric skills , which I have utilized to maintain cross team collaborations and training graduate and PhD students . Outside of work , I enjoy organizing social events and taking care of my plants . I also like meeting new people over a cup of tea . Feel free to connect . Technologies :",proteins;small molecules;interaction;screening
Scientist . Proteogenomic analysis of clinical multiple myeloma samples for identification of new therapeutic targets and risk classification Proteomic profiling of proteolysis targeting chimera PROTAC compounds Plasma proteomics DIA providing proteomic support for scientific collaboration . . Technologies :,molecular glues;developing
"Computational Biologist Scientific Investigator . . Experienced Research Scientist with a demonstrated history of working in data analysis . Skilled in Bioinformatics , Protein Chemistry , Life Sciences , Research , and Biotechnology . Strong research professional with a PhD in Bioinformatics .. Technologies :",
"Lecturer in Computational Biology . . Research interests : Quantitative immunology biological physics . Incoming Group leader UCL Previously Lewis Sigler Fellow Princeton , PhD ENS . Technologies :",
"Postdoctoral Research Associate . . Current research interests : Thermodynamics and kinetics of transport across bacterial and plant systems . Cryo EM and integrative modeling , recent project : AstraZeneca COVID 19 vaccine PDB : 7RD1 , published in Science Advances . Structural and mechanical properties calculation of plant biomass for sustainable energy applications . Transport cycle of small multidrug transporters . Anti microbial peptide AMP and lipid interactions . Methods : Molecular Dynamics , Cryo EM and Integrative Modeling , Free Energy enhanced sampling techniques , free energy perturbation , Membrane permeability calculations , Finite Element Methods Google Scholar : https : scholar.google.com citations user KSW1uFAAAAAJ hl en . Technologies : CryoEM",proteins;structure
"Director Bioinformatics . Developing and executing on long term strategy to maximize the impact of genomic data on patients life . developing informatics strategies to enable the discovery of new therapeutic modalities from pre clinical studies in early stage research . Data platform for multiple high dimensional ' omics assays . Support Reverse Translation effort by generating insights into biomarkers from clinical trials . Bioinformatics scientist and software engineer with over 10 years of cutting edge industry research experience designing and implementing systems for the analysis of meta genomic data for microbiome , cancer research and other disease areas . Beyond bioinformatics , I am interested in modern software development , Big Data and large scale compute environments . Publications : Over 20 publications in highly ranked scientific journals . For a full list , see PubMed http : www.ncbi.nlm.nih.gov pubmed term Reeder Jens auth My group is hiring Contact me for detials .. Technologies :",
"Senior Principal Scientist . . Andrew Bordner , Ph.D. is a data scientist who applies his quantitative background to diverse problems in machine learning , natural language processing , computational biology , and clinical data analysis . EMAIL ADDRESS : ajbordner gmail.com . Technologies :",
"Chercheur postdoctoral . Equipe : Dr. Marc Ruff Project : Characterization of new HIV conformational inhibitors Activity : Scientific project management . Scientific and technical monitoring . Used methods : site directed mutagenesis on DNA plasmid Human cell culture L2 , Production of protein from mammalian cells Vaccinia virus , cell viability assay , Production of lentivirus L2 Test of protein stability by NT Prometheus NanoDSF , ThermoFluor , Kd determination by fluorescence anisotropy , Single particle analysis by cryo electron microscopy , crystalization screen X ray crystallography . Ing nieure motiv e , forte de 10 ann es d'exp rience dans la purification de prot ines et d acides nucl iques , ma trisant la biologie mol culaire et la biochimie , je poss de galement des comp tences en gestion d quipe et de projets . Professionnelle nergique et dot e d'un solide esprit d ' quipe , je sais g rer les situations de stress et atteindre mes objectifs dans les d lais en optimisant les co ts et avec un souci de la qualit .. Technologies : Xray;CryoEM;DSF;FP",nucleic acids;proteins;expression;interaction;stability;structure
"Postdoctoral Research Associate . . I am a protein biochemist currently working on biochemical and structural aspects of the ligand gated ion channel membrane proteins from bacterial , insect and mammalian origins . Previously , I worked on Dehydroascorbate reductase enzymes from plants and proteins that inhibit bacterium to bacterium and bacterium to plant DNA transfer . Macromolecular X ray crystallography Soluble and membrane protein crystallization Soluble and membrane protein expression using various tags in mammalian , insect E. coli expression systems Downstream processing on KTA systems Biochemical biophysical characterization of protein ligand and protein protein interaction Molecular biology techniques . Familiarity with biological structures Experience in working in a Linux UNIX environment Limited experience : cryo EM TEM operation , negative staining and grid preparation for single particle reconstruction .. Technologies : Xray;CryoEM",membrane proteins;characterization;expression;structure
"Research Engineer Staff II , Digital Health Lab . Initiate and lead Mobile Health mHealth research projects for digital diagnosis and digital intervention development in various controlled and free living scenarios Develop novel algorithms using mobile sensor data , signal processing , and machine learning to monitor and improve patient 's health Benchmark consumer grade algorithms and systems against hospital grade gold standards Lead academic research collaboration with external partners Generate innovative idea and file patents in digital health Prepare proof of concept and demo for innovative health applications on smartphones and smartwatches Lead the clinical protocol design and IRB procedure for human subject studies . I am an experienced 12 years multi disciplinary researcher intersecting Mobile Health Wearable Computing , Computer Science , Machine Learning , and Health Informatics . I am applying Machine Learning algorithms to infer health e.g. , stress , behaviors e.g. , conversation , and spatio temporal contexts from wearable and mobile sensors . My research focuses on how high level inferences and their representations can engage end users with mHealth technologies in daily livings to improve their health and wellness . I designed and conducted several scientific user studies to collect data , develop and validate machine learning models , and wearable devices with end users in free living conditions . My research is enabling the design of just in time mobile health interventions using mobile devices including smartphone , smartwatch , and earbuds . Experience and Expertise : 12 years of experience in supervised and unsupervised Machine Learning algorithms e.g. , SVM to model user 's behaviors . 12 years of experience in designing and conducting experiments to collect data from human using wearable mobile sensors in lab and field . Experienced in analyzing and visualizing thousands of hours of mobile sensor data e.g. , physiology , accelerometer , and audio to extract useful health and behavioral insights . Experienced in designing algorithms for just in time health intervention by fusing multi sensor data . Developing software frameworks Python and Android for collecting , cleaning , predictive modeling , and visualizing mobile sensor data . Leading multidisciplinary research with several US universities including Harvard Medical School and University of California San Francisco . Publishing and presenting research papers in premier computing venues with several paper awards and recognitions Citation : 875 , h5 index : 15 . Devices Physiological Device ECG , Respiration , IMU , Audio , GPS Languages Python , Java , Android , C C Databases Oracle , MySql , SqlLite Tools PyCharm , Notebook , Weka , Matlab . Technologies :",
"Assistant Professor . . The main focus of the research in my group is to resolve and understand the structure of membrane and membrane associated proteins and complexes combining cryo electron microscopy cryo EM , and molecular modeling . I have a long time interest and experience in defining the membrane bound structure of coagulation Factors VIII and V and their complexes with the respective proteases : Factors IXa and Xa by Cryo EM aiming to generate functional models of these important for blood hemostasis macromolecular assemblies . For these purpose we have developed lipid nanoplatforms such as : single bilayer lipid nanoutubes LNT , nanodiscs ND and vesicles , which facilitate the functional structure determination of these proteins and complexes at closest to physiological conditions . The overall goal is to apply , develop and combine our knowledge of the membrane bound organization of blood coagulation complexes with our nano technology expertise to understand the intricate mechanisms causing hemophilia and thrombosis and translate our expertise to other macromolecular systems , such as the membrane proteins and complexes involved in synaptic transmission and neuron excitability . Cryo EM methods developed in our laboratory are : Helical organization of membrane bound proteins onto LNT . 2D crystallization onto functionalized lipid monolayers , single particle analysis of macromolecules bound to ND , vesicles or as soluble macromolecular complexes . We are also combining single particle Cryo EM and cryo electron tomography to study macromolecular complexes at a cellular level . The structures we resolve by cryo EM are optimized with molecular modeling and molecular dynamic simulations to understand their functional implication . The cryo EM studies are complimented with additional biophysical and structural techniques as Circular Dichroism , Dynamic Light Scattering , SAXS , X ray and NMR at closest conditions to the one employed for the cryo EM studies .. Technologies : Xray;CryoEM;SLS DLS;CD;NMR",membrane proteins;structure
". . Cell culture techniques including Transient transfection , Flow cytometry , soft agar assay , primary culture explantation , cell banking , routine culturing , Growth curve studies of monolayer and suspension cells . Gene expression Analysis such as Real Time Reverse transcriptase PCR . Recombinant DNA cloning , expression and purification of recombinant proteins including membrane proteins . Membrane Protein Topology Prediction . IMAC , SDS PAGE , Site directed Mutagenesis , Western blotting , primer design .. Technologies :",membrane proteins;expression;stability
"Senior Researcher . . Leopold L Ilag currently works at the Department of Materials and Environmental Chemistry , Stockholm University . Method Development : Native Mass Spectrometry Strategies Ambient Mass Spectrometry SALDI Mass Spectrometry Electrocapture Mass Spectrometry Applications on : Membrane Proteins , Molecular Machines , Amyloids , Small Molecules in the context of the Environment , Food Analysis and Health ORCID : https : orcid.org 0000 0003 3678 7100 . Technologies :",
Project Leader Downstream Process Development . . A structural biologist with strong interest in membrane proteins trying to understand the fundamental links between structure and function at an atomic level . I have an extensive experience in all areas of the process from protein engineering to protein expression and purification and structure determination and analysis . I have been successful in determining the structures using both X ray crystallography for smaller molecules as well as cryo EM for protein complexes .. Technologies : Xray;CryoEM,membrane proteins;engineering;structure
"Head of Nanobody Research Platform Discovery . Heads several groups of the Nanobody Research Platform , including the Discovery group Lead Generation and Lead Characterization , the Bioanalysis and Immunogenicity team as well as the Ablynx ' Project leads . . . Technologies :",antibodies;characterization;developing
"Technischer Assistent . Mein Aufgabenbereich bezieht sich auf die Assistenz in der Elektronenmikroskopie . Dazu z hlt Pr paration von Zellen , Proteinen , etc zur Analyse per Elektronenmikroskop Freeze Fracture , Zelleinbettungen , Negative Stain , Cryo EM , Handhabung von Fl ssiggasen , Mikroskopvorbereitung , Anlernen am Ger t , sowohl auch Auftragsarbeiten nach Anfrage und anfallende Labort tigkeiten . . . Technologies : CryoEM",proteins;structure
"Director of Research . . Broadly speaking , I work to to develop analysis and software solutions to enable biologists and clinicians to make discoveries faster and work more efficiently toward improving how DNA can inform our personalized medicine . I currently lead a team of research scientists to push the envelope of genomic medicine ... with a little bit of COVID surveillance on the side . I 'm a classically trained geneticist with a Ph.D. in Molecular , Cellular , and Biochemistry Ph.D. and minor in Computer Science . Population genomics . Pharmacogenomics . Computational biology . Bioinformatics . Knowledge engineering . Biocuration . COVID surveillance . All these topics and more are in my wheelhouse .... Technologies :",
"Senior Principal Scientist , Patient Data Analytics Lead . . . Technologies :",
"Associate Laboratory Director . . As Berkeley Lab s ALD for Computing Sciences , Carter oversees the Laboratory s Computational Research Division CRD , the National Energy Research Scientific Computing Center NERSC , and the Energy Sciences Network ESnet . Carter has held technical and management roles in the CS Area , first as a technical member and then manager of the National Energy Research Scientific Computing Center NERSC User Services Group . During this time , Carter played a key role in procuring and deploying two of the world s fastest supercomputers at NERSC . After these successes , he served as CS Area Deputy for eight years and nearly four years as CS Area Deputy for Science . He has held leadership roles in several initiatives within the Department of Energy DOE complex , most notably the Exascale Computing Project and Quantum Information Science QIS . Before coming to Berkeley Lab , Carter was a scientific staff member at IBM Research Almaden , San Jose , Calif. , in the Science and Technology Department . There he conducted research and development of computational chemistry methods and software for application to technology challenges . He holds a Ph.D. in Theoretical Chemistry and a Bachelor s degree in Chemistry from the University of Sheffield , United Kingdom , followed by postdoctoral work at the University of British Columbia , Canada and at IBM Research . Specialties : Quantum Computing ; Programming and Tuning Techniques for Scientific Applications ; Using High Performance Computing in Chemistry and Physics ; High performance Computing Procurements ; . Technologies :",
"Data Scientist . . https : github.com thompsar Ten years of experience in data modeling , statistical analysis techniques Monte Carlo methods , ridge regression , etc . and the development of data analysis utilities Python , Mathematica , Matlab Over ten years of experience in data analysis , presentation and publication of scientific findings Experimental background in spectroscopy , including pulsed EPR DEER , continuous wave EPR , single molecule TIRF microscopy , Time resolved FRET . Technologies : Xray;CryoEM;NMR;FRET",
"Associate Director . . 25 years of experience as an analytical scientist and team leader within Discovery and Development Global Teams within several disease areas . Specialised in analytical characterisation and achiral and chiral purification of pharmaceuticals using a range of chromatographic techniques . Also expert in physicochemical analysis GLpKa , LogD7.4 and elemental analysis Ion Chromatography , TGA , DSC , CHN S . My current research themes are within investigating chromatographic biomimetic assays to asses drug molecule physicochemical characteristics and actively presenting and publishing in this area . A track record of delivering innovative solutions to two big pharmaceutical organizations within Development and Discovery whilst continuing to foster and encourage fundamental analytical research Specialties : Analytical Separation LC , SFC , CE , DSC , TGA , MS , CAD Characterization : Ion Chromatography , KF , Heavy Metals , Residual Solvents , Physicochemical Analysis : Lipophilicity , pKa , Albumin binding Chiral : LC , SFC and CE methods In vitro in vivo correlations : Non specific binding assessment for PET ligands , Melanin binding , Drug Promiscuity assays , Drug lipid affinity to assess GPCR protein association rates Conference Lead Organizer : Chromatography Society and ACS meetings . Technologies : DSC;NMR",small molecules;characterization
"Lab leader Target discovery . . Fields of expertise : Enzymology , biocatalysis , protein engineering and structural biology .. Technologies :",enzymes;proteins;engineering;structure
"Staff Scientist , Computational Biology . . Interdisciplinary computational biologist with 20 years post PhD academic and industry experience : 13 years innovating multidisciplinary strategies that combine custom molecular cellular biology , bioinformatics , systems biology , and NGS methods to discover drug targets , drug molecules , early detection biomarkers , and mechanisms of cellular patho physiology in oncology Leading multidisciplinary teams of computational and bench scientists Conceptualizing and developing novel NGS algorithms and protocols Conceptualizing and implementing custom computational strategies and pipelines to process , integrate , and interpret heterogeneous large scale molecular profiling data for inferring physiologic mechanisms and for biomolecule discovery Creating DNA based libraries by various molecular synthetic biology methods Designing , sequencing , and analyzing antibody repertoires Creating innovative RNA , protein , and DNA bioinformatics algorithms and computational pipelines for genome scale molecular profiling platforms and applications Integrating data analysis with literature research to infer molecular cellular mechanisms and to identify and prioritize candidate drug targets Developing new computational methods for systems biology and functional genomics Applying machine learning methods for biological applications Strong working knowledge of molecular biology and human genome transcriptome proteome Deep interest in , and broad knowledge of , numerous biological disciplines . Technologies :",
"Senior Principal Scientific Researcher . . Driven protein engineer and biochemist ; passionate about using large molecule engineering strategies to therapeutically modulate human disease biology . With 8 years of industry experience in the design , optimization production of large molecule based therapeutics including complex non antibody fusions , multi specific antibodies , antibody polymer conjugates and antibody drug conjugates .. Technologies :",antibodies;proteins;engineering
Associate Director of Research Development for Science and Engineering . . . Technologies :,
"Principal Scientist . I joined Symphogen in January 2014 . Here I am leading the MS lab and responsible for characterization across all Symphogen s projects , which are directed against cancer and immuno oncology targets . Project stages range from early discovery to late stage clinical development and covers single antibodies as well as antibody mixtures up to six antibodies in a single product . Qualitative and quantitative mass spectrometry is used extensively in my work at Symphogen intact subunit mass analysis , MRM , peptide mapping by LC MS or MAM . I employ both heavy isotope labelling and label free MS technologies for quantitation of biopharmaceuticals and their critical quality attributes CQAs . These MS technologies are used extensively to support development within CMC upstream , downstream , formulation , analytical and for mapping out degradation pathways of antibodies during stability and forced degradation studies . In addition I am responsible for composing eCTD documents for regulatory submissions INDs , IMPDs based on my characterization work , particularly within characterization and comparability . . My key strength is a comprehensive background in analytical protein chemistry . Since 1996 I have been working with a broad range of protein analytical technologies , initially applied in the field of proteomics 1996 to 2004 and later in the development of biopharmaceuticals 2004 to present . I have extensive , hands on experience with a broad range of technologies , including : Mass spectrometry MALDI , ESI , APCI , ion trap , Orbitrap , triple quad , TOF , LC MS Chromatography HPLC UPLC , RP , SEC , IEX , affinity , HPAEC PAD UV , refractive index , fluorescence , electrochemical and multi angle light scattering detectors Electrophoresis 1D 2D PAGE , IEF , Western blotting Field flow fractionation HF5 and AF4 Micro Flow Imaging manual and automatic Fluorescent dyes for monitoring aggregation Thioflavin T , Proteostat Automated Edman sequencing The technologies have been applied to different protein related tasks ; including : Identification and quantitation of proteins Characterization of posttranslational and chemical modifications Characterization of product and process related impurities Analysis of aggregation and particle formation Study of higher order structures Analysis of protein ligand interactions I have worked with the development pre clinical to registration of biopharmaceuticals for the following clinical indications targets : Cancer targets antibodies targeting EGFR HER1 , HER2 , HER3 , Met Immuno oncology targets antibodies targeting PD1 , LAG3 , TIM3 Hemophilia recombinant Factor VII analogue Neutropenia recombinant PEGylated G CSF analogue Short Bowel Syndrome recombinant and synthetic GLP 2 analogue Rheumatoid arthritis and other autoimmune diseases antibodies targeting CD20 , GM CSF Specialties : Analytical protein chemistry , purification and characterization of proteins , method development and validation .. Technologies :",antibodies;formulation;quality;stability
Department Head . Department head for Computer Science and Data Sciences . . Technologies :,
Project Manager and Bioinformatics Analyst . . . Technologies :,
"Principal Lecturer in Artificial Intelligence . . Bioinformatician with extensive background comprising sequence analysis , next generation sequencing , gene expression analysis , phylogeny phylogenomics , gene expression analysis , and computational modelling of gene regulatory networks , morphogenesis and evolution . Additional experience in ecosystems modelling , biodiversity and sustainability , machine learning , big data , development of bioscience software systems and software engineering in general including agile practices . Currently leading bioinformatics with Plant and Fungal Trees of Life project at Kew .. Technologies :",
"Principal Scientist . . Everything one invents is true , you may be perfectly sure of that . Poetry is as precise as geometry . Gustave Flaubert . Technologies :",
Clinical Trial Manager . . . Technologies :,
"Senior Bioinformatics Scientist . . Contact me if you want to design content optimized and cost effective disease gene panels based on array and sequencing platforms for screening high volumes of samples . Computational biologist with many years of industry experience in next generation sequencing analysis , cancer biology , biomarker discovery , patient stratification , genome annotation , novel algorithm design . Specialties : Bioinformatics : RNA seq data analysis , Microarray expression analysis , sequence alignment , motif discovery , transcript structure annotation , biomarker discovery , Gene Ontology , Ingenuity Pathway , statistics , building novel algorithms to analyze expression data . Key skills Bioinformatics : Python programming , blast , bowtie , tophat , cufflinks , Picard , SAMtools , BEDTools , and GATK , UNIX bash , Illumina NGS troubleshooting and QC , multiplex PCR primer design , SQL , NGS variant calling Programming : Python , PERL , R , SQL , Java , C , PHP .. Technologies :",
"Director . Household Care Application Research . People and line management . R D and innovation management . Business portfolio unit management Laundry Dish including innovation projects , R D and product portfolio . Strategic customer engagement . . People management , R D , customer collaboration and partnership , strategy , portfolio management , change management , research , innovation culture , project management . Formulation , granulation , product development , upscaling , enzyme performance , enzyme stability , laundry , HHC , dish wash , detergents , carbohydrases , proteases , product innovation and positioning . Pd . D. from CHEC group at DTU . Combustion and particle technology , combustion of staw and other biofuels , deposition and corrosion .. Technologies :",
". . My educational background is in biochemical , physical , organic and inorganic chemistry including a lot of practical experience . During my studies I specialized in biochemistry and did my PhD in biology . After having been in academic research for more than 9 years , I changed over to the applied development in the industrial sector . For more than 2 years I am working now in the supply operation part to assure the quality of analyses and products . Skills and knowledge : Protein chemistry under aerobic and anaerobic conditions Working with soluble enzyme complexes and membrane proteins Protein expression , characterisation , crystallisation , purification via FPLC and analysing via SDS PAGE and Western Blotting Gradient centrifugation Enzyme activity assays and stabilisation , determination of KM values of enzymes and pH dependency of enzyme activity , co factor investigation Developing enzyme assays , purification strategies and buffer modification X ray crystallography basic knowledge Analytical : HPLC GC and MS 1H NMR UV VIS Spectroscopy Analytical chemistry Different types of chromatography Microbiology : Cultivation of aerobic and anaerobic organisms in small scale and up to 10 L Strain modification Molecular biology : PCR Cloning and transformation Plasmid preparation and analysis Site directed mutagenesis Agarose gel electrophoresis Other Skills and knowledge : LEAN Thinking Statistics Design of experiments Data handling Documentation , Quality assurance Project leading and management Planning and organisation of lab work for lab technician . I am highly organised , flexible and very motivated . I am an excellent team player but I am also working independently . I am ambitious and curious and therefore always trying to enhance my skills and expertise by taking part in advanced training courses related to my projects and work .. Technologies : Xray;NMR",enzymes;membrane proteins;characterization;expression;formulation;stability;structure
"Application Scientist , Structural Biology . . A science and technology enthusiast . Ph.D. in Bioengineering with extensive research experience in computational molecular biophysics , spearheaded multiple collaborative projects working with experimentalists , both in fundamental and applied scientific research . Proficient in complex biological data analysis , biomolecular simulations and protein engineering with keen interest in drug discovery and protein design . I m passionate about leveraging my knowledge and skills , working in a dynamic interdisciplinary environment to help maintain the disease state at bay . Key skills : Data analysis , Molecular Dynamics , Python , NumPy , Pandas , Enhanced sampling techniques , Statistical analyses , Protein structure modeling , Protein design and engineering , Protein structural analysis , Structural bioinformatics , Scientific writing , High Performance Computing HPC , GPU based parallel computing , Stochastic simulations and modeling , MATLAB . Familiar : Machine learning tools and algorithms Areas of interest : Protein structure dynamics , Synthetic biology , Machine learning , Drug discovery , protein design and therapeutics , Intrinsically disordered proteins , Computational Biology , Scientific writing and editing . When not doing research , I love spending time outdoors hiking , cycling etc . , trying out new cuisines , and traveling .. Technologies :",
"R D Senior Engineer . R D in the field of microelectronic . Analyses are performed via TEM technique fitted with EDS and EELS spectroscopy . . Highly skilled in high resolution TEM , BF and DF imaging , EDS analysis , crystallographic analyses , dislocation imaging , and EELS . Structural analysis : Transmission electron microscopy High Resolution TEM STEM HRSTEM HAADF , BF DF imaging Electron diffraction , SAED Weak Beam Environmental TEM and CRYO Electron Microscopy . WAXS Wide X ray Angle Scattering similar to XRD technique EXAFS Synchrotron Hambourg , Hasylab Desy Chemical analysis : EELS STEM EELS EDX STEM EDX XPS on K alpha Thermo Scientific SEM Nano Auger Other : SEM Focus Ion Beam UV spectroscopy Sample preparation plane view cross section Use of a glove box Cryo sample preparation . Expertise in Dedicated softwares data analysis : Digital Micrograph TEM EELS , JEMS , TIA STEM , Esprit EDX , ImageJ , Athena EXAFS , Gnuplot , Reduwaxs WAXS , CasaXPS .. Technologies : Xray;CryoEM",structure
"Professor in AI Neuroscience . . Aldo Faisal is Professor of AI Neuroscience at Imperial College London . He is Founding Director of the 20Mio UKRI Centre for Doctoral Training in AI for Healthcare at Imperial College London . He is also Chair in Digital Health at the University of Bayreuth . His own research labs are the Behaviour Analytics Lab at the Data Science Institute and the Brain Behaviour Lab at the Dept . of Bioengineering and Dept . of Computing . He is Associate Editor for Nature Scientific Data and PLOS Computational Neuroscience and acted as program chair area chair in key conferences e.g. KDD , Neurotechnix , NIPS , IEEE Body Sensor Networks . He was elected in 2016 to the Global Futures Council of the World Economic Forum Davos , named Associate Group Head MRC London Institute of Medical Sciences and made an honorary senior fellow of Oxford University s Nuffield Department of Clinical Neuroscience . Dr Faisal 's expertise lies in combining data driven methods , machine learning and human behaviour and neuroscience to develop novel human aware AI technology that helps people in health and disease .. Technologies :",
"Graduate Research Assistant . . Ph.D. Candidate in Materials Science and Engineering , MS in Computer Science Stanford University Yi Cui Group Email : zwzhang stanford.edu Address : 476 Lomita Mall , Stanford , CA , 94305 Field of Interest : Battery , Energy Storage , Battery , Machine Learning , Data Science , Cryo EM , etc . Technologies : CryoEM",
"Reserch Scientist . Involved in midstream and downstream activities for the development of biotherapeutics within the area of rare diseases . In vitro analytical assays . Design of experiment methodologies . . Science is one of my greatest passion , and it fuels my natural curiosity . I studied structural biology , a discipline that encourages patience , perseverance , and method . I am a medical science with industrial experience from R D and MedTech company and Ph.D. in biomedicine from the Karolinska Institutet . As a big lover of technologies and novel therapies , I wish to contribute to society by creating value using science based data and to advance human health . A background in biophysics , biochemistry , cell biology , and clinical research gives me a unique multi dimensional approach that enables me to tackle scientific questions strategically . Skillfull within multiple sectors biotech , MedTech , and digital , I became more interested to bioprocess development and design of experiment methodologies . Proactive , energetic , and organized . I tend to approach my projects in a holistic way . With strong interpersonal skills and the right energy , I convey my messages clearly and support the team with suggestions and initiatives . If you would like to collaborate please contact me at : dioguardi.elisa outlook.com Looking forward to hearing something from you Have a great day . Technologies :",biologics;developing;structure
"Senior Scientist Amgen Research Copenhagen ARC . . A scientist with significant depth in biophysical methods , screening and development sciences within drug discovery . Current tasks include driving Early Development of new candidates , project management , method development and technology searching with external collaborators and managing thereof . Actively searching opportunities for collaborations to strengthen scientific knowledge .. Technologies :",small molecules;screening
"Senior Director , Global Head of Bioanalytical Science . Responsible for managing Global Bio Analytical Science department . GLP Test Facility Management . Development , validation and execution of PK , Immunogenicity and Biomarker methods for non clinical and clinical studies . Specialties : Antibody Generation Discovery 15 years High Throughput screening Assay Development Lab Automation Bioanalysis GLP . Technologies :",antibodies;quality;screening
"Postdoctoral Researcher . . Molecular Biology to Marine Biology and back Currently researching function and disfunction of TRPV1 in neurons with the Jara Oseguera Lab in Austin I have experience in cell culture , FLIPR assays , peptide and protein purification , mass spectrometry LSMS and MALDI , SDS PAGE , HPLC , de novo sequencing , and scanning electron microscopy . My other research skills involve protein structural determination through TEM and cryo EM . My previous work involves biochemical characterization of toxins produced by family Ranellidae . I enjoy marine field work , statistics , and have experience in the upkeep of marine aquariums and their inhabitants . . Technologies : CryoEM",proteins;structure
"PhD Student . Thesis Title : Improving Electron Microscopic Hardware to Push the Resolution Limits in Single Particle Cryo EM Advisor : Prof. Dr. Holger Stark , Department of Structural Dynamics , Max Planck Institute for Biophysical Chemistry . I kinda like big scopes , especially the electron ones , like a TEM you know . That 's why I am working on them .. Technologies : CryoEM",
"Staff Scientist . . Meng Yuan currently works at the Department of Integrative Structural and Computational Biology , The Scripps Research Institute . Meng does research in Structural Biology , Protein Science , and Molecular Virology .. Technologies :",proteins;structure
"Assistant Professor . . I currently hold a Sapere Aude Research Leader grant from Independent Research Fund Denmark to start my group at the Department of Biomedical Sciences , Faculty of Health and Medical Sciences , University of Copenhagen . My research interests center on the signaling properties and unexplored biology of adhesion GPCRs and the implications of this receptor family in human health and disease . My lab combines a suite of cellular signaling assays with the development of novel single molecule microscopy approaches . I look forward to connect with you . Technologies :",membrane proteins;characterization
"Assoc . Principal Scientist . Screening Compound Profiling Dept high content assays , imaging and image analysis , laser scanning plate cytometry Acumen eX3 supporting LeadID and mechanism of action studies in infectious disease , immune oncology , cardio metabolic disease , and neurobiology . Manager of high content analysis and flow cytometry center of excellence . . I am a highly skilled and accomplished assay developer project leader for drug and target discovery , having worked at Schering Plough Research Institute and Merck Research Laboratories for many years . My professional training concentrated in infectious disease and oncology research , after earning a BS Microbiology from University of Michigan , and an MS Biology from Seton Hall University . Drug and target discovery using phenotypic and mechanistic , cell based assays is a career specialty . This expertise has been applied to successful drug discoveries and clinical candidates for infectious disease and oncology drug targets . More recently , I have focused my work in the application of high content analysis , phenotypic screening and single cell analysis to drug and target discovery . Specialties : high content assays , phenotypic screen design and execution , drug discovery assay development , cell based assays , automated microscopy , laser scanning plate cytometry , live cell image assays , flow cytometry , calcium flux assay FLIPR , reporter gene assays luciferases , lactamase , SeAP , mammalian cell culture and transfection , BacMam and lentiviral transduction , virus plaque assays , mammalian protein expression and western blot analysis , stable cell line isolation and characterization , Data software : Spotfire , GraphPad Prism , Image analysis . Technologies :",small molecules;screening
Senior Scientist . . Passionate scientist with experience in small molecules drug discovery . The main area of my competence is immunology and cancer immunotherapy and its possible translation in human pathologies . Excellent communication and leadership abilities coordinated to advance cutting edge projects .. Technologies :,small molecules;interaction
"Senior Bioinformatics Scientist . . Skills Computer languages : R , Python , Java , Javascript , HTML and Javascript libraries JQuery , D3 , Databases : Postgres , MySQL Technologies : Git Github https : github.com lia978 , Linux UNIX , Bash scripting , Vim , Sublime Text , electronic notebooks R markdown , Jupyter , High Performance Computing Clusters qsub , AWS Bioinformatics : NGS data processing and analysis Affymetrix microarray , RNA seq , L 1000 , Whole Exome Sequencing , SNP arrays , PacBio , ribosome profiling Biomarker discovery analysis differential gene expression , pathway enrichment , MOA discovery Web portal development and data visualization ggplot2 , RShiny , Javascript HTML with experience in web server configuration Apache and Nginx Mining of cancer genomics and toxicogenomics data TCGA , DepMap : CCLE Achilles , Drugmatrix , ConnectivityMap , STITCH , CTD , etc Other project based experiences : Hierarchical Bayesian modeling JAGS , machine learning supervised classification , graph algorithms conditional independence in networks . Technologies :",
Senior Scientist I . . . Technologies :,
"Senior Scientist Antibody Engineering Protein Chemistry . . I am a multi skilled biotech professional , with a strong background in Protein Chemistry and Antibodies . My professional interests are : antibody characterization , bispecific antibodies , novel tools for antibody characterization . Fields of Expertise : Protein Characterization , Biochemistry , Assay Development , Antibodies , Bispecific Antibodies . Technologies :",antibodies;characterization;developing;engineering
"Postdoctoral Fellow . I am working on the fundamental understanding of the passivation behavior of Li alloying anodes for Li ion batteries in organic carbonate electrolytes by employing advanced characterization techniques . . I am currently working as a Postdoctoral Researcher at Lawrence Berkeley National Laboratory Berkeley Lab with Kostecki Research Group . My research interests include fundamental understanding of the electrode electrolyte interfaces in rechargeable batteries by employing advanced characterization techniques , such as cryogenic electron microscopy cryo EM , scattering type Scanning Near field Optical Microscopy s SNOM , Electrochemical Impedance Spectroscopy EIS , and X ray Photoelectron Spectroscopy XPS . I have over six years of research experience of working on the rational design of nanostructured electrode materials , such as bimetallic alloys including , metal phosphides and metal chalcogenides , MXene and carbon nanofibers , for advanced alkali ion and alkali metal batteries . I earned my Ph.D. in Mechanical Engineering with Nanotechnology concentration from The Hong Kong University of Science and Technology HKUST , 2022 QS World Ranking : 34 under the supervision of Prof. Jang Kyo Kim and Prof. Baoling Huang . I won the Overseas Research Award from the School of Engineering of HKUST to perform research on MXene based metal anodes at the Drexel University , USA under the supervision of Prof. Yury Gogotsi , for a duration of six months in 2020 . I was awarded the Postgraduate Studentship Award from HKUST to carry out my Ph.D. study as a full time student for 4 years 2016 2020 . I have also worked as a Postdoctoral Research Associate in the same group for one year and two months Oct. 2020 Dec.2021 before moving to Berkeley Lab . I did my Bachelor of Mechanical Engineering from the National University of Sciences and Technology NUST where I was awarded a Merit Based Scholarship 2011 2015 . I also worked in a battery industry , Atlas Battery Limited , for seven months before starting my Ph.D. research on batteries in 2016 .. Technologies : Xray;CryoEM",
"Research Scientist Teamleader . . I am a member at the Structural Genomics Consortium in Frankfurt . My focus is on structure based drug discovery , which includes various methods such as compound screening , hit validation and x ray crystallography . As a staff scientist at the Frankfurt Cancer Institute , my typically research area is in oncology , but I am not limited to that . I am a huge supporter of open science and currently working at the stimulating interface between academia and pharmaceutical industry . Our goal is to make potent , selective , and broadly characterized small molecules chemical probes available to the public without restrictions and free of charge . I am always interested in scientific questions and open for collaboration within my field . Don t hesitate to contact me . Technologies : Xray;ITC;DSF;NMR",proteins;small molecules;interaction;structure
"Sr Research Scientist . Support the Induced Proximity Platform Engineered and optimized the production of challenging protein targets for chemical screening , structural and or functional studies Generated and characterized high quality protein reagents at milligram quantities Analyzed and investigated ligand protein complexes through structural and computational approaches Served as the point of contact to coordinate the production of high quality protein reagents from colleagues CROs Support antibody production Purified bi specific antibodies and performed analytics to support proof of concept studies . Hands on experience engineering and optimizing the production of challenging protein reagents for small molecule screening , biophysical , structural and or functional studies Experienced in structural studies of transmembrane receptors and intracellular signaling complexes using cryo EM and or X ray crystallography Extensive experience with different protein classes : soluble , membrane and secreted Proficient in various expression systems : E. coli , insect , and mammalian cells Adept at protein engineering and design approaches Collaborative team player with a dauntless mindset to tackle long standing important problems in drug discovery and scientific advancement . Technologies : Xray;CryoEM",antibodies;proteins;characterization;expression;interaction;structure
"Sr Research Associate Lead Optimization Molecular Engineering . . team player , enthousiastic . Specialties : PCR , cloning , prokaryotic protein expression , Pichia pastoris , CLC bio software , SDS PAGE , Western blotting , Northern blotting . Technologies :",antibodies;expression
"Bioinformatician . Bioinformatician and Biocurator at WormBase Gene , Variant and Strain Curation . Biologist . Biotechnologist . Bioinformatician . Biocurator . Experienced in academic and industrial research and development environments .. Technologies :",
"Director Protein Chemistry and Assays . . Ph.D. in Biochemistry and Docent in Microbiology combined with several years of experience in development of enzyme products for industrial applications , project leadership and line management . Research interests while working at the University were in the fields of protein folding , structural biology , membrane proteins and microbial physiology . Associate professor at Lund University between 2004 and 2008 . Industrial experience includes development of enzyme products for e.g. detergent , biofuel , food and technical applications , build up of focus area , including technology scouting for protein stability and coordinating activities with Contract Research Organizations CROs . As a project leader I have experience both with global cross functional projects 5 10 FTEs where products were developed in close collaboration with strategic customers and also with technology projects to develop new methodology and work process and drive change across the global Novozymes R D. As a line manager I have 5 years of experience of a department with 25 direct reports including strategy and vision building , target setting , performance management and people development and budget responsibility . Currently in a Director role with a function of 50 employees and 4 department managers as direct reports . Specialities : Development of enzyme products from innovation to manufacturability assessment and hand over to scale up Global , cross functional project leadership and change management . Technologies :",enzymes;developing;engineering
Leonard Kleinrock Professor in Computer Science . . . Technologies :,
Bioinformatics Scientist . . Recent PhD graduate of Baylor College of Medicine . Experienced with statistical analysis and visualizing large genomic datasets in R. Constantly learning and improving . Passionate about building data analysis and visualization tools to solve challenging problems .. Technologies :,
"Lead Bioinformatics Scientist . . I am a bioinformatics scientist at Natera . Before joining Natera I was a scientist at illumina AI labs working on developing deep learning machine learning for genome interpretation . I was a data analyst in Genentech and prior to that a post doctoral fellow at the Trapnell lab at University of Washington . I have a PhD at Genetics , Bioinformatics , and Computational Biology from Virginia Tech . I am a data scientist interested in Big Data analysis of Next Generation Sequencing data using deep learning methods . I am particularly interested in application of machine learning in bioinformatics , and computational biology . I analyze gigabytes and terabytes of data related to next generation sequencing everyday and write algorithms to mine for meaningful information in these huge data .. Technologies :",
"PHD Student . Studying the neutralizing potentials of antibodies using biochemical assay and cryo EM . I am a lover of interdisciplinary science and also a published researcher in the field of virology , structural biology and bioinformatics . I explore viral genomes to predict their pathogenesis and design potential vaccine and drugs against their infectious proteins . Currently , I m seeking to understand the immune response to chronic viral infection . Technologies : CryoEM",antibodies;structure
"Research Scientist . Process optimization , formulation and online characterization of RNA ASO LNPs LNP formulations : design , optimization and production lab scale RNA ASO LNP high resolution characterization : size , size distribution , particle number , stability , morphology , encapsulation efficiency , RNA concentration and integrity , ... Development of analytical techniques and methods Development , optimization and application of analytical methods for physicochemical characterization of : Nanodrug delivery systems Exosomes and Extracellular Vesicles nano sized Protein aggregation kinetics . Multidisciplinary scientist with a strong background in analytical chemistry and nanomedicine . Experience with gene therapeutics , RNA LNPs , formulation and expert in field flow fractionation instrument coupled with UV Vis , MALS , DLS , RI , ... Expertise in RNA characterization from concentration to integrity purity . Technologies : SLS DLS",carriers;characterization;formulation;stability
". . I am a physician scientist with years of medical practice and electrophysiologist molecular biologist with almost 10 years of experience on structure function biophysics . I have expertise in molecular biology and solid experience on research and deep understanding for both functional and structural approaches for ion channels , membrane proteins and receptors , expression patterns and their functionality and structure determination , besides on hearing biophysics and receptor pharmacology and physiology . I have expertise on techniques such as ; molecular biology , molecular cloning , molecular engineering , protein purification and blotting , conventional electrophysiology two electrode voltage clamp , patch clamp , gating current experiments cut open , fluorescence size exclusion chromatography and protein blotting , heterologous expression systems e.g. mammalian cells and Xenopus oocytes . Besides , I have experience in computational modeling homology alignment and structural modeling , kinetic analyses , and modeling in addition to MatLab coding and signal analyses . Since 2016 I have been working on hearing biophysics and physiology at cellular and molecular level majorly using heterodyne laser interferometer which could detect sub nanometer scale movements of organ of Corti upon sound at a surgically removed intact cochlea .. Technologies :",membrane proteins;structure
"Director of Data Science and Statistical Computing . Leading the research and development of tools , applications and infrastructure to enable the analysis of genomic data . . . Technologies :",
"Chief Scientific Officer . . Pascal Merchiers has expertise in leading drug discovery and preclinical development programs including the follow up on the scientific , IP and BD aspects . In view of this , he has been involved in a large number of collaborations with pharmaceutical and academic partners . Through the course of his career he has been working in functional genomics , gene therapy , antibody NBE discovery and development and protein drug delivery . His therapeutic expertise mainly resides within neurodegenerative diseases , immune oncology , angiogenesis and ophthalmology . Because of this broad background other therapeutic areas can be easily acquired . In addition , he has been leading scouting and in licensing activities for different companies . His main interest is to discover and develop novel therapeutics or technologies that will address unmet medical needs and will contribute to the development of new or existing companies . . Technologies :",antibodies;biologics;carriers;idps;developing
"Principal Scientist Functional Characterization Bioassays . Lead of the late stage projects team with focus on development and validation of functional assays for release , stability and characterization of bispecifics . . Professional with extensive expertise in leading development and validation of bioassays , functional assays and molecular assays for release and stability of vaccine products and monoclonal antibody products . Strong leadership skills and several years of experience in managing a team of technicians . Specialized in assays used for viral vector based vaccines and functional assays for antibody cancer therapeutics ADCs and bispecifics . Passionate about strategy and challenges within CMC analytics and product characterization .. Technologies :",antibodies;biologics;characterization;stability
Assistant Professor . . . Technologies :,
"Principal Scientist , project leader . Drug discovery and development . Seasoned organic medicinal pharmaceutical chemist with supervisory and leadership experience . Passionate about creating value by harnessing the power of chemical and life sciences . Successfully led drug discovery initiatives and expediently resolved challenging problems in R D and manufacturing by seamless integration of medicinal , analytical , physical , and synthetic organic chemistry . For example : 1 . Invented and delivered drug candidates , including first in class candidates , for novel targets of unmet medical needs 2 . Enabled pharmaceutical products to be re instated on the market by solving impurity issues Has published 27 research articles in peer review journals including JACS ; and has 8 patents or patent applications . . Technologies :",small molecules
"Chemist . As shown in the list of publications , my professional research career reflects a widening scope from the process related analytical chemistry chromatography with different advanced detectors to biochemistry enzymes as cellulases , laccases , tyrosinases , peroxidases etc . as well as structural characterization NMR , MS , FTIR of natural macromolecules proteins , lignin , polysaccharides . VTT is a well known international , multidisciplinary research center of excellence . I have over twenty year s research experience from different VTT laboratories metal , chemical technology , biotechnology including leading of research team , projects , supervision of MSc , PhD and postdoc students . Several scientific research visits abroad UK , Denmark , Holland , USA , NZ enabled networking and international collaboration globally as evidenced in the number of joint articles . In addition , I have been in charge FTIR and MALDI TOF MS laboratories and industrial customer services for several years . Albeit these efforts , it has been a considerable effort to establish a research group under circumstances where the operations depend mainly on the external , competitive funding . Making the best out of possibilities , focusing feasible research targets , collaborating worldwide and joining forces I have directed my research from analytical chemistry and structural characterization of enzymatically catalysed cross links towards bio nano material science lignin and protein nanoparticles and biophysical techniques DLS , QCM D including microscopy AFM , SEM , TEM , currently on going at AALTO EU Zelcor . At Finnish Custom Laboratory my research is focusing on the exploitation the gained competence on textiles and some other non food products for classification and heading . . Adjunct professor in analytical chemistry with strong competence from the various research organizations VTT , UH , AALTO , Metropolia . Skilled in analytical NMR , FTIR , MALDI TOF MS , HRGC , SEC , DLS , DSC etc . techniques , polymer chemistry proteins and lignin , biotechnology enzymes and nanomaterials lignin and protein nano micro particles , nanocellulose . The applications include bio process chemistry , medicine , foods , cosmetics and textiles . Education from the University of Helsinki , Department of Chemistry Kumpula Campus including doctor of philosophy PhD and pedagogic studies in adult education 60 cr . at the University of Helsinki . Research funding ACADEMY OF FINLAND Academy project . University of Helsinki , Department of Chemistry Tailored biomass derived self assembling building blocks for bionanomaterial applications 2014 2018 Academy project , VTT . Enzymatic cross linking of food proteins : impact of food protein folding on the mode of action of cross linking enzymes . Project manager of two PhD students in collaboration with Dr. Perttu Permi UH , BI , currently Prof. at the University of Jyv skyl , Finland . PI Prof. Johanna Buchert currently at LUKE 2006 2009 Research grant , VTT . Postdoctoral researcher . Collaborators Hannu Maaheimo , Harry Boer . Modelling protein oligosaccharide interactions in chitinases MSc Nana Munck , PhD student 2002 2003 Research grant , VTT . Postdoctoral studies in England 1998 2000 Research grant , VTT . PhD and Licentiate studies . Ty el m ss olevien jatkokouluttaminen 50 1994 1997 EU Research contract , AALTO . EU ZELCOR . Zero Waste Ligno Cellulosic Bio Refineries Project manager . Collaboration with prof . Monika sterberg . 2016 2020 TEKES Research contract , AALTO . Project manager . Collaboration with prof . Monika sterberg AALTO Colloidal Lignin adhesives and coatings . 2016 2018 Research contract in Drug 2000 program , VTT . Kohdeproteiineihin sitoutuvien molekyylien NMR seulonta menetelmien kehitt minen . Project manager collaboration with Prof. Arto Annila , University of Helsinki , Finland . 2001 2007 Research contract , VTT . Post doctoral studies in UK SAR by NMR , structure activity relationship by nuclear magnetic resonance 1999 2000 EMIL AALTONEN FOUNDATION Research grant , VTT . Finalization of the licentiate studies 1995 . Technologies : SLS DLS;DSC;NMR",enzymes;characterization
"Account Executive , EMEA . Leading the next wave of software revolution in life sciences and biotechs with Benchling . Biotech R D is radically transforming our world , and modern science requires modern software . Trusted by the world s most innovative biotech companies , Benchling supports customers in getting breakthrough products to milestone and market faster . The world s most innovative biotech R D organizations are built on Benchling and we work with them to ensure they stay ahead . . I love promoting scientific knowledge and making it more understandable . Involved in Biotechs and Companies which use unique approaches to adapt to future market needs . Specialized in life sciences areas : Cloud Solutions Software ELN LIMS , Biomolecular interactions SPR , Structural biochemistry cryo EM . Technologies : CryoEM;SPR",
"Kemiker . . I am a committed and passionate person , specialized within the field of protein chemistry and microbial conversion of keratin by product . Generally I have a broad understanding of many aspect within biochemistry biotechnology . My previous work experiences have led me to work both with basic research , while also as of late with more applied research . This has required more a pragmatic and goal oriented view on my research . Working on a project with several stakeholders including industrial partners has strengthened my ability to analyse the requests of stakeholders for me to plan and conduct experiments that correctly answer their questions . These aspects of my education have lent me to be both able to think out of the box and explore new solutions , while staying focused and keeping track of the end target . I am very detail oriented and thrive when standards are set high with regards to quality and efficiency . During my studies a have utilized a range of technical methods and equipment for the study of proteins : Enzyme Characterization : Assay development Activity measurements Substrate specificity analysis Activity optimization Stability kinetic Protein Characterization : Protein stability chemical , thermal Structural characterization CD , DLS Binding affinity ITC Protein and Peptides Purificatio : n HPLC and UHPLC Affinity , SEC , IEC , IMAC and RP Mass Spectrometry : Proteomics LC MS MS Protein identification MS Product analysis Analytical Methods : Absorbance , fluorescence , CD , DLS LC MS MS ITC , DSC Electropheresis . Technologies : ITC;SLS DLS;DSC",enzymes;proteins;characterization;stability
"Principal Scientist , Machine Learning , Structural Bioinformatician . . . Technologies :",
"Quality Control Chemist . QC Chemist roles : release of pharmaceutical products by approving physico chemical results , batch journals etc . according to GMP rules improving processes by updating and writing instructions problem solving with OOS , CAPA and Change Control standardization and qualification of excel sheets for data storrage and treatment contact person for external colaboration partners and national QC network group close collaboration with lab technicians . I am very engaged in my work tasks and work place . In my work , I generate overviews of tasks and timelines to keep projects on track and I pay special attention to details e.g. in data driven processes . I am network oriented and like to share knowledge through collaboration and teaching . My professional interests range from Pharmacuticals Chemistry Green energy and Sustainable transitions . Contact details : 45 4283 1443 LouiseHertzholm gmail.com Specialist experience Pharmaceuticals : Formulation development , stability studies in house at CMO , freeze drying process characterization , coordination of cross group activities in analytical support . Techniques : Fluorescence spectroscopy , Differential Scanning Calorimetry DSC , Isothermal titration calorimetry ITC , Circular Dichroism CD , Dynamic and static light scattering DLS SLS , Microflow Imaging MFI , Mass Spectrometry MS , Reverse Phase High Pressure Liquid Chromatography RP HPLC and Size Exclusion Chromatography SEC .. Technologies : ITC;SLS DLS;DSC;CD",biologics;characterization;interaction;quality;stability
"Scientific Director Biochemical Processes . The Bacterial Vaccine Discovery and Early Development unit headed by Dr. Jan T. Poolman focuses on introducing new and improved sub unit vaccines based on outer membrane proteins and carbohydrate conjugates directed against bacteria with a high rate of morbidity and mortality . Bacterial Vaccine Discovery and Early Development . Janssen Vaccines Prevention , Pharmaceutical Companies of Johnson and Johnson . Michel Beurret , Ph . D. , is Scientific Director Biochemical Processes at the Bacterial Vaccine Discovery Early Development unit of Janssen Vaccines Prevention , Pharmaceutical Companies of Johnson Johnson , in Leiden The Netherlands . Dr. Beurret is an expert in Carbohydrate Chemistry and Biochemistry and in its application to Vaccinology . He is a graduate of the Universit Grenoble Alpes France , where he studied the structure of capsular polysaccharides from Klebsiella , with use of selective bacteriophages . Thereafter , Dr. Beurret joined Dr. H. J. Jennings as a post graduate fellow scientist at the National Research Council Ottawa , Canada , where he performed structural and immunological studies on lipopolysaccharides of N. meningitidis . His first professional assignment was with Praxis Biologics now Pfizer Vaccine Research in Rochester NY , USA , where he helped develop pediatric conjugate vaccines against a variety of pathogens S. pneumoniae , N. meningitidis , and S. typhi , leading to such products as Prevnar and Meningitec . In his former positions at the National Institute for Public Health the Environment RIVM and the Netherlands Vaccine Institute The Netherlands , Dr. Beurret was again involved in the development of pediatric conjugate vaccines S. pneumoniae , H. influenzae type b , and S. dysenteriae . This work has led him to assist the RIVM and its partners in the developing world India , Indonesia , and China in conducting successful technology transfer activities . In partnership with the WHO GLO VQ network , these projects have led to the development of an international course on Quality Control of Hib vaccines . Specialties : Conjugate vaccines Carbohydrate chemistry and biochemistry Anti bacterial vaccines Bacterial immunochemistry Technology transfer . The views expressed on this website weblog page are mine alone and do not necessarily reflect the views of my employer . . Technologies :",biologics;developing
Principal Scientist . . . Technologies :,
Staff Scientist . Development of microbial community analysis pipeline . Development of metagenomics sequence assembler using suffix array . Transcriptomics analysis in human oral biofilm . Metagenomics data analyses in human mouth and gut . . Algorithm design and software development Next generation sequencing NGS data analysis Metagenomics and metatranscriptomics Machine learning High performance computing . Technologies :,
"Principal Scientist . . Expertise in small molecule drug discovery with 22 years extensive medicinal chemistry experience . Led or engaged in 16 early full phase drug discovery programs , which led to 8 clinical candidates responsible for the discovery of the MCHR1 clinical candidate BMS 950458 and a key contributor to 3 others . Among these clinical candidates , the DPP4 inhibitor clinical candidate eventually resulted in marketed drug Onglyza , the 4 others were will be advanced to either phase I or II clinical trials . Medicinal chemistry experience spans multiple therapeutic areas : cardiovascular , metabolic diseases , obesity CNS , and fibrosis drug discovery . Broad knowledge of drug discovery ADME PK , toxicology , pharmaceutics , and computational chemistry . Excellent problem solving skills and ability to generate , aggregate , and interpret multi parameter data to formulate actionable medicinal chemistry plans . Supervised internal CRO scientists in research . Defined patent strategy and drafted patents . Author coauthor of 20 scientific publications and 20 presentations . Co inventor on 21 patents patent applications . . Technologies :",small molecules;screening
"Director , Machine assisted Modeling Analysis . . Ben leads the Machine assisted Modeling Analysis team at the Laboratory of Systems Pharmacology , Harvard Medical School https : indralab.github.io . He is the recipient of a DARPA Young Faculty Award for 2020 22 and the DARPA Director 's Fellowship Award for 2022 23 . His research is at the intersection of systems biology , bioinformatics and artificial intelligence , and aims to understand how biological cells work and react to drugs and environmental signals using computational approaches . Ben developed INDRA , a software tool which automatically assembles biochemical mechanisms extracted from the scientific literature into explanatory models , generalized this technology to other domains , and led the development of a number of innovative applications using this technology human machine dialogue systems , self updating disease models , large scale knowledge graphs , etc . .. Technologies :",
"Senior Scientist . Leading microbial strain improvement campaigns for plant health and animal health using industrial strains Natural strain improvement of soil microbes for Food , Health and Nutrition . Molecular tools development for both Gram positive and Gram negative soil bacteria and establishment Idea maturation , planning and execution , data result analysis and documentation . I am experienced molecular biologist microbial strain engineer , working in the field of industrial microbial biotechnology for improving microbes for sustainable agriculture or production of bulk chemicals and fine chemicals . Having broad knowledge and intensive hands on experience on molecular biology , synthetic biology , metabolic genetic engineering , analytical chemistry and fermentation technology , I can be a good team member as well as key player . Bio based industries are KEY HUB to fulfill demand supply chain of food , chemicals and pharmaceutical products as well as protecting environment in this era . Therefore , I am very much interested to take new challenges associated with biobased industries or pharmaceutical companies . Area of expertise and Interests : Strain engineering , Upstream process and Fermentation Key technical Skills : Cell cultures Growth profiler , Biolector Antibacterial antifungal assays MIC tests Strain identifications and CFU counts Natural Strain improvement Recombinant DNA technology Metabolic engineering Genome Editing MAGE , CRISPR Cas9 , mediated by Phase transduction , Homologous recombination based , etc . RNA prep , cDNA synthesis , RT PCR , qPCR . Protein Engineering Heterologus protein expression Bioinformatics DNA Sequencing Mutagenesis Classical and target specific Bioprocess Fermentation Separation technology Metagenomics High throughput screening Analytical Chemistry HPLC , LC MS , GC MS , NMR . Technologies : NMR",proteins;engineering
CIFRE PhD . Industrial PhD between the Cryo EM group at the Biophysics and Structural Biology departmenr at Sanofi and the Structural Biology group at Pasteur Institute . . . Technologies : CryoEM,proteins;characterization;structure
"Associated Researcher . . Over 5 years of experience in computational biology research . Focused on various projects in the domains of bioinformatics , predictive modelling , data analytics , computational structural studies of macro molecular protein complex and protein biochemistry . Associated in different projects related to : Predictive modelling using clinical and gene expression data Immunology Oncology data analysis Target Ideation Patient stratification based on gene expression data Metagenomics Next generation sequencing Big data analysis Cardiomyopathy disease model Protein structural analysis coiled coils , cardiac muscle proteins Programming I am passionate about translational research that benefits the drug discovery domain . Practical Exposure Predictive Modelling methods : Regression linear , logistic limma , glm , gmlnet , lasso . SVM , Random Forest , ANN . Classification and Clustering methodologies . Bioinformatics methods : BLAST , FASTA , RASMOL , Swiss PDB viewer , PYMOL . MALDI TOF , ClustalW , MODELLER , Docking tools , MD . Various other Bioinformatics tools . NGS Metagenomics analysis methods : FASTX , FASTQC , SoapDenovo , Velvet assembler . Megahit , CLARK , PPSP , Megan , MaxBin . Databases : TCGA , CBioportal , NCBI , SwissProt , GenBank , DDBJ , EMBL , SGD , PIR , Pfam , PDB , Prosite , Pubmed , OMIM , TIFR Computer Skills : Os Windows XP , Linux Language R , Perl , Python , HTML Protein Biochemistry methods : Protein purification high low salt , affinity chromatography . Hands on experience AKTA , TECAN . SDS PAGE , UV visible Spectroscopy .. Technologies :",
"Postdoctoral Researcher . . I am a theoretical and experimental biophysicist , and currently a postdoc at UC San Diego . I am using Cryo EM and molecular dynamics simulations to understand the structure and function of PTEN induced kinase 1 PINK1 , a mitochondrial serine threonine protein kinase encoded by the PINK1 gene . It is thought to protect cells from stress induced mitochondrial dysfunction . PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria . PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation . Mutations in this gene cause one form of autosomal recessive early onset Parkinson 's disease .. Technologies : CryoEM",proteins;structure
"Executive Director , Head of Research Data Sciences . . . Technologies :",
"Associate Principal Scientist . . Profile : Biochemist with expertise in studying signal transduction pathways in immune and non immune cells . Identifying and validating novel targets in the areas of respiratory and autoimmunity diseases within the IMED RIA Unit at AstraZeneca . Enthusiastic and dedicated scientist with strong technical skills and interpersonal skills , who enjoys creative and innovative work , with the ability to work independently or as part of a team to deliver new medicines for the treatment of the unmet medical need . Core skills : Strong expertise in studying signal transduction pathways and elucidating molecular mechanisms Experience in working in academia and the pharmaceutical industry with proven success in both environments Broad spectrum research skills enabling flexible addressing of various scientific questions in different cellular therapeutically settings Creative and innovative thinking to identify novel targets for treatment of various disease in the area of respiratory or autoimmunity . Technologies :",small molecules;proteins;developing
Senior Computational Biologist . . . Technologies :,
"Principal Scientist . Drug development Broad computational support to line projects developing new candidate drugs within the new modalities space peptides and oligonucleotides for the respiratory area Enzyme engineering Broad computational support to in house enzyme optimization projects for bio catalysis Graduate and postdoc project application and supervision Research project proposal writing for graduates and postdocs and subsequent supervision upon approval . Co supervision of PhD students with the University of Cambridge and the Southampton University in the United Kingdom External collaboration scouting and establishment Pro actively reaching out to scientific software development companies to engage in research collaborations . Involved from initial contacts CDA drafting , to collaboration agreement drafting , managing and contributing to the science . External collaboration management Member of the management team on an EPSRC Prosperity Partnership five year projects to investigate topics of national and global importance with the University of Manchester of bio catalysis and new modalities . Project Management Managing of a large cross function , cross location internal project to enable optimal environment for therapeutic peptide research Target identification Deliver tractability and feasibility analysis for new therapeutic targets within the respiratory area . Technology scouting and implementation Scouting for new computational technologies , securing testing and in house implementation Manuscript writing for highly ranked peer reviewed journals . Experienced protein engineer with project management experience . Keywords : molecular modelling , sequence comparison , data analysis , project management , technology scouting , innovation , external collaboration coordination and patent strategy . Enjoying working in close collaboration with experimentalists . Project management experience in bio technology product development . In depth knowledge of both academic and industrial research environments ; strong analytical skills and good written and oral communication skills . Experienced player in cross functional activities , a careful listener and a good communicator . At home in many different countries and cultures ; multilingual . Interested in R D in large bio technology bio pharmaceutical companies . . Technologies : Xray;ITC;DSC;CD;NMR",
"Principal Scientist . . Expert in Targeted Protein Degradation TPD background in Bioscience with strong expertise in small molecule degraders e.g. PROTAC technology , molecular glue degraders and assay development . I have 10 years of post PhD research experience , currently driving and developing drug discovery projects in the CRO sector , with a lead role in the TPD area . Extensive experience as team leader , line manager and mentor .. Technologies :",molecular glues;small molecules;developing;interaction
"Senior Research Fellow . . I am Senior Research Fellow in Artificial Intelligence at the University of Oxford and a Fellow at the Alan Turing Institute . I am also co Director of the Health Data Research Alan Turing Institute Wellcome PhD programme in Health Data Science . I studied undergraduate Engineering at Cambridge where I did my masters dissertation with Professor Andrew Blake at Microsoft Research on digital image analysis . Afterwards , I joined the EPSRC funded Life Sciences Interface Doctoral Training Centre , led by Professor David Gavaghan in Oxford where I completed my doctoral thesis in Statistics under the supervision of Professor Chris Holmes . I subsequently took up MRC Fellowship in Biomedical Informatics before joining Imperial College London as a Lecturer in Statistics in the Department of Mathematics . I rejoined Oxford where I became Associate Professor in Genomic Medicine as a Principal Investigator at the Wellcome Trust Centre for Human Genetics . I then became Reader and then Professor of Artificial Intelligence at the Universities of Birmingham and Manchester prior to rejoining Oxford . I sit on the development group for the Academy of Medical Science FLIER programme which I co developed with the panel . I am also on the committee of the MRC Methodology Research Programme from April 2020 . I co lead the Machine Learning sub domain for the Genomics England Clinical Interpretation Partnership in Quantitative Methods , Functional Genomics and Machine Learning .. Technologies :",
"Senior Principal Scientist . . Peptide and protein parenteral drug development . Physico chemical characterisation of protein and peptide formulations . Formulation and stability of adenovirus viral vector based products Key competence : Drug development from discovery to marketing Parenteral , nasal and pulmonary drug delivery development . Peptide , protein and gene therapy drug delivery and formulation development . Surfactant and polymer physical behaviour . Physical and analytical techniques such as : CD and UV Vis spectroscopy , AFM , MALLS , DLS , SLS , HPLC , surface balance with LB deposition , and DSC . Building regulatory strategies and authoring of key regulatory documentation , for IMPD , IND , NDA , BLA , MAA etc . Patent , applications , oppositions etc . Pharmaceutical manufacturing , aseptic fill finish , scale up , process development , process validation qualification , cartridges , vials and prefilled syringes .. Technologies : SLS DLS;DSC",carriers;peptides;proteins;characterization;formulation;stability
Professor W1 . . Biochemist and structural biologist with a focus on cryo EM and X Ray crystallography . Passion for communicating science and making research accessible to a broader audience .. Technologies : Xray;CryoEM,proteins;structure
"Principal Bioinformatics Scientist . . I teach computers how to do biology . That is because I m not a computer scientist nor a biologist , but rather a true bioinformatician . I am a highly self motivated free thinker that is not afraid of failure . My 10 years of experience performing bioinformatics based research has made me comfortable with a wide range of biological data in both academic and start up environments . I excel in positions that require integration of a large number details into a bigger picture . Skills : Comfortable programming in Perl , C , Java , Mathematica , Matlab , R , and Haxe in both Linux and Windows environments Software development in a live lab setting Extensive MySQL experience Capable of using HPC environments to process large data sets Comfortable with many RNA Seq technologies : Illumina , 454 , and Ion Torrent Genome and transcriptome assembly : CLC and Cufflinks Differential expression analysis : EdgeR and DESeq Genomic annotation tools : BLAST , HMMs , KEGG , and EC Familiar with numerous tools for aligning sequence data and building phylogenetic trees and networks Proficient at aligning proteins structures and using them as phylogenetic markers Detailed understanding of microbial genomics , classification , and phylogeny Knowledge of evolution and function of many macromolecular structures . Technologies :",
"Senior Bioinformatics Scientist . . Bioinformatics computational biology An experienced computational biology researcher with in depth knowledge and strong track records in the analysis and integration of next generation sequencing NGS datasets . Profound comprehension in the analysis and integration of multi omics platforms , including RNA sequencing , ChIP seq , ATAC seq , DNA methylation , DNA sequencing , Ribo seq , etc . Extensive experience in supporting drug target identification and development in rheumatoid arthritis RA . Successfully developed a novel machine learning algorithm for human brain single cell RNA seq data processing and neuron subtype identification . Designed a single cell NGS pipeline for cell surface marker detection and batch effect elimination for different types of single cell data . Published more than 20 papers , including first authored papers in prestigious journals such as Science and Nature Communications . Strong computer programming skills in R , Python , Perl , etc . , and the ability to apply diverse machine learning algorithms and computational tools to support drug target discovery . Effectively led and participated in numerous collaborative projects with various labs , institutions , and pharmaceutical companies . . Technologies :",
"Senior Research Scientist . Early stage drug discovery , novel small molecule autophagy modulators as potential therapies for Alzheimer 's disease AD and cancer , HTS hit to lead generation and optimization , photoaffinity labeling for cellular protein target identification , PK PD studies , cellular homeostasis and protein degradation , medicinal chemistry and chemical biology . Multidisciplinary research expertise in the areas of multi step organic synthesis , scalable asymmetric synthesis and process development , early stage drug discovery , medicinal chemistry , chemical biology and enzyme catalysis etc . My current research efforts in the Chemical Biology Program at Sloan Kettering Institute have been focused on : Early stage drug discovery , discovery and development of novel small molecule autophagy modulators as potential therapies for Alzheimer 's disease AD and cancer , HTS hit to lead generation and optimization , photoaffinity labeling for cellular protein target identification , PK PD studies , cellular homeostasis and protein degradation . In addition , I explore other non laboratory activities that include Entrepreneurship , Business Development , Life science and Healthcare Consulting etc .. Technologies :",idps;proteins;small molecules;interaction;screening
PHD Candidate . Advisor : Dr. Engin Ozkan Used directed evolution via yeast surface display to affinity mature protein glycan and protein protein interactions Performed surface plasmon resonance SPR to measure binding affinity and kinetics of protein glycan and protein protein interactions Solved x ray crystallography complexes and validated binding interfaces through mutagenesis and SPR Performed cryogenic electron microscopy cryo EM . . Technologies : Xray;CryoEM;SPR,proteins;interaction;structure
"Principal Research Scientist . . Experienced Structural Biologists with core expertise in structure function analysis of disease targets Highly skilled in X ray crystallography , Electron Microscopy and SAXS Strategic and technical leadership to structure efforts for drug discovery : Identification of compounds for structure studies , structure determination and analysis , and communicating results to cross functional teams across diverse therapeutic areas Experience with building automated capabilities to determine high resolution structures of protein ligand complexes Technical expertise encompassing all steps of Structure Based and Fragment Based Drug Discovery SBDD and FBDD : extensive hands on experience with designing protein constructs , cloning , protein expression and purification , high throughput screening , biophysical and biochemical assays , crystallization , data collection and structure determination Proficiency with single particle cryo EM including grid preparation , data collection and processing , 3D reconstruction and model building Strong written and verbal communication skills Interdisciplinary background in Physics MS , Biophysics and Biochemistry PhD and Chemistry . Technologies : Xray;CryoEM",proteins;small molecules;interaction;screening;structure
"Team Lead Scientific Monitoring Bioanalysis . Head of the Scientific Monitoring Team which supports all bioanalytical outsourcing activities to facilitate measurements for diverse non clinical and clinical studies in accordance with the principles of GLP and GCP . Head of Scientific Monitoring Team , bioanalytical outsourcing , bioanalysis , GCP GLP regulated Environment , non clinical studies , clinical trials , Project Management , toxikokinetic assessment strong Background in LC MS analytics , chromatographic separation , proteomics and small molecules Analysis cell based assays , lysosomal Enzyme kinetics , antibody drug conjugates ADCs and Assay development . Technologies :",
Assistant Professor of Biomedical Engineering . . . Technologies :,
Director of Scientific Computing . . . Technologies :,
"Senior Laboratory Manager , Scientist II . . Experienced Laboratory Manager with a PhD in Chemical Biology and a demonstrated history of working effectively in both academic and biotech research groups . Skilled in the daily operations of both Laboratory and Office Management , Permitting Compliance , BSL2 Lab Build Out , as well as research in Cell and Molecular Biology and Small Molecule Screening . Strong research professional with a skill for wearing multiple hats and developing pragmatic solutions for the ever changing needs of a growing organization . . Technologies :",small molecules;screening
"Associate Principal Scientist . . Associate Principal Scientist at Red Glead Discovery working as Medicinal Synthetic chemist . Previously Associate Principal Scientist at AstraZeneca R D M lndal Lund Respiratory Inflammation . Chemistry Project Leader in discovery of five drug candidates taken to phase I or II clinical trials in three different projects , lately in LTC4s against Asthma AZD9898 . Experience from all stages of the drug discovery process from target identification biological mechanism principle to small molecule identification and optimization both for oral or inhaled administration . Broad experience cross target classes Proteases , GPCR 's , Kinases , Nuclear Hormone Receptors , Enzymes , Bromodomains . Inventor of 16 patents covering 10 nominated Drug Candidates oral and inhaled . Key Competences : Leading Doing Lead Identifiaction and Optimization . Drug Design Discovery Kinases , MMP 12 , GR , RARg , Neutrophil Elastase , CCR2b , CRTh2 , p38 MK2 , Leukotriene C4 Synthase LTC4s , Bromodomain 3 . . Technologies :",membrane proteins;small molecules;interaction
"Senior Scientist Discovery . . Experienced Scientist with a demonstrated history of working in the biotechnology industry . Skilled in Antibodies , Membrane Proteins , Molecular Biology , Biotechnology , and Research and Development R D . Strong professional with a MSc Molecular Medical Biotechnology focused in Medical Biotechnology , Pharmacology from Ghent University . . Technologies :",antibodies;membrane proteins;developing
"Postdoctoral Researcher . . Just take a moment and imagine what is happening in your body while you are reading this : ATP is generated from the food you just had a few minutes ago . DNA is repaired , replicated , tightly packed and segregated which is my favorite part of the cell cycle . Signaling cascades are turned on and off .. Most of these incredible processes are based on the activities of enzymes and my fascination for their structure and function began early during my undergraduate studies when I learned that it is possible to look at the structure of biological macromolecules at atomic resolution . Thus , I focused on structural biology , especially X ray crystallography , during by Bachelors degree at the University of T bingen and my Masters degree at the University of Bayreuth . My PhD gave me the great opportunity to learn single particle cryo electron microscopy at the Gene Center at the LMU Munich . Cryo EM is revolutionizing the field of structural biology and I looking forward to great insights into biological mechanisms by this technique in the next years . During my PhD I enjoyed working as part of a team and I believe that a good team will achieve more than the single people on their own . As a result of my collaborative PhD project , we were able to publish our research in two high impact journals Nucleic Acid Research and Molecular Cell . I had the luxury to be given a lot of freedom in my project and this taught me to work independently and to plan and organize my own project . I have a high level of self motivation and determination , which was necessary when our Molecular Cell paper was rejected by three journals prior to its publication . Now that I have finished my PhD I am eager to apply my knowledge and learn more in the field of cryo EM . Additionally , I have taken an interested in enzyme engineering , which I think is a great technique to design pathways for product generation or degradation in a more sustainable and environmentally friendly way . I am eager to learn more about this field in the future . Outside of the lab I like to play theater and I was part of several performances in the last few years . I also enjoy doing Yoga and listening to music , especially classical . I am happy to connect with anyone , who is interested in proteins , enzyme engineering , science in general or just wants to have a chat .. Technologies : Xray;CryoEM",proteins;structure
Head of Protein Science . http : confotherapeutics . com . veli pekka . jaakola confotherapeutics . com . Membrane Protein Biochemist . Interest : SBDD for GPCR NCE NBE : Structural biophysics for GPCR ; Non G protein related signaling and modulation of GPCRs ; Continuous learning and development ; Human capital management . Technologies : DSF,membrane proteins;small molecules;screening;structure
"Head of Information Science . . Leadership , communication , problem solving , team and community building skills developed in global environments . Experienced working in academic , enterprise and startup environments . Very broad scientific and IT knowledge , particularly around Data , Computational Science , Biology , Chemistry and Agile Methodologies . Expert in architecture , build , maintenance and support of computational science and data platforms , with a strong record of delivery and leading change .. Technologies :",
"Scientist . Independently developed and executed primary cell based assays Western , In Cell Western ICW , and enzyme linked immunosorbent assay ELISA to evaluate PROTACs for target degradation Applied knowledge of signaling pathways to independently develop and execute cell based assays to ascertain target engagement Independently developed and executed technically challenging proliferation assays involving innately problematic cells Proactively earned certificate from Yale University to work with induced pluripotent stem cells iPSCs Proposed , championed , and managed restructuring of cell line processes handling and banking to ensure the future and lasting integrity of the company s internal cell line bank , to align the company s data , and to ensure an efficient and productive workflow for the Biology group Initiated and championed creation of a laboratory support position to increase efficiency and productivity of the Biology group Supervised , mentored , and trained two junior laboratory support colleagues in fundamental laboratory skills to support them in their career aspirations to transition to bench positions Ensured funding of summer internship program by compiling and submitting required documentation to receive the state of Connecticut s Technology Talent Bridge Internship Program TTB grant Routinely analyzed , interpreted , organized , delivered , and effectively communicated high quality data to cross disciplinary teams of industry and academic scientists . During my career in the pharmaceutical and biotechnology industries , I have applied my diverse skill set in both drug discovery and development reagent generation to translational biomarkers to help identify and develop novel therapies small molecule and Proteolysis Targeting Chimera PROTAC to treat cancer and neurological diseases . . Technologies :",molecular glues;small molecules;developing;screening
"Staff Scientist , Research Development . On January 22 , 2013 , Life Technologies announced the acquisition of BAC BV . On February 3 , 2014 , Thermo Fisher Scientific completed the acquisition of Life Technologies corporation . I am currently involved in antibody ligand discovery and protein expression . . Research fields : protein display technology , protein expression and generation of new antibody leads . Planning , development and directing multiple projects simultaneously to develop new antibody leads and new technologies in the field , including transfer of technology to other projects . Advise and directs scientists regarding application of new technology . Assists Director when necessary with report , manuscript , and presentation preparation . Participates in scientific conferences and academic forums to represent the company and gather technology knowledge . Technologies :",antibodies;expression;interaction
"Senior Scientist . Preparation of Technical documentation for IVDR Design of analytical performance studies Coordination of Direction for Use updates for IVDR Design and risk management responsible for multiplex diagnostic allergy test . Senior Scientist within assay development in medical device industry with a background from academic research . With a master in chemistry from the study program of biomedical chemistry at Kalmar University and a Ph.D. in medical science from Uppsala University , I have a mix of chemistry and biomedicine in my background . My research as a Ph.D. and postdoc focused on protein aggregation and neurotoxicity in neurodegenerative diseases Alzheimer 's disease and ALS . Over the years , I have developed an independent work style and a persistent mind set with a strong aspiration to reach the set goal . In more recent years , I have aquired several years of experience from in vitro diagnostics , involving product development , assay verification , analytical performance studies , risk management , maintenance of product requirements and product information . Currently , I am employed as a senior scientist at Thermo Fisher Scientific , working with verification and product care of allergy tests . If you wish to discuss new opportunities with me , please don t hesitate to contact me by e mail : ann sofi.johansson outlook.com . Technologies :",
"Principal Scientist . MS T Team Leader . Pharmaceutical Product Support Lead of Technical Projects , Product Transfers , Process Optimisation , Manufacturing Support , Validation . Support Products Operations technical functions worldwide . Resolve manufacturing or analytical issues for products . Provide technical support as a SME to cross functional teams during development , commercial launch or problem solving for a given Active Pharmaceutical Ingredient or drug product . Provide individual technical support for scale up activities . Leading multifunctional teams to accomplish projects , and coordinate scale up campaign activities with the applicable functional groups . . Formulation scientist for pharmaceutical , food and cosmetic application , specially focused on drug delivery . International background and experience . Specialties : Drug delivery . Technology transfer . Coating technology by Fluidized bed and Drum coating for pharmaceutical , cosmetic and food application . Microencapsulation by air flow , spray drying , solvent evaporation , double emulsion , ionic gelation , electrostatic and vibration methods . Confocal Laser Scanning microscopy . Liposome preparation ; Spray Dried powder production . . Technologies :",carriers;formulation
"Postdoctoral Researcher . . A multilingual structural biology researcher with five year research experience in academia and solid background in single particle cryo EM and protein biochemistry . With well developed organizational and communication skills to work as part of international multidisciplinary teams . Eager to explore career paths in industry in areas of structural biology , structure aided drug discovery , biologics or therapeutic antibodies .. Technologies : CryoEM",antibodies;proteins;structure
"Senior Engineer Researcher . Electron microscopy research facility management . Biologist with experience in the interdisciplinary field of Molecular Biology Neuro , Cell , Structural Biology , Zoology , Biochemistry , EvoDevo with focus on 3D imaging techniques including cryo EM .. Technologies : CryoEM",proteins;structure
Associate Director of Bioinformatics . . Creative Bioinformatics Scientist with 15 years NGS data analysis and molecular biology expertise .. Technologies :,
"Scientist Modeler . . Experienced computational modeler and data scientist with a demonstrated history of working in the pharmaceuticals industry . Skilled in Matlab , R , python , computational models , and machine learning . Strong research professional with a Master 's degree focused in Bioinformatics from Northeastern University . . Technologies :",
"Principal Scientist II . Transitioning to more lab operations activities and enabling others to do their work more efficiently . At the bench , in collaboration with project teams , designing constructs for optimized protein expression and purification . Expression systems include Mammalian , Baculovirus insect cells , BacMam and E.coli . Proteins are used for assays , structural determinations , validation tools or therapeutics , as needed . . I am using my molecular biology expertise in the Drug Discovery process at all stages . My current focus is on anti malarial targets , in conjunction with the Novartis Institute for Tropical Diseases . The goal is to produce high quality protein reagents for validation experiments , biochemical and biophysical screening and crystallography , cryo EM and NMR for structural determinations , as well as bio therapeutics . I have worked on both small molecule and biological therapeutics project teams . Proud to supervise two great associates and help manage lab operations , including : move planning , packing , cleanouts ; line function champion for global protein database testing and implementation ; voting member of Institutional Biosafety Committee , and others .. Technologies : CryoEM;NMR",proteins;characterization;interaction;screening;structure
"Scientist , Computational Biology . . I recently earned my PhD in genetics and molecular biology from Emory University where I used machine learning techniques specifically dimensionality reduction , clustering , and regression to understand how epigenetics fold the human genome . I formulated novel predictive models capable of recapitulating three dimensional genomic architecture from one dimensional chromosome features . I m now looking to bring my expertise in statistics and my experience distilling insights from big , noisy datasets to bear on exciting new domains as a data scientist . I m most passionate about communication , storytelling , and data visualization . I m always looking for creative ways to visualize data for both exploration and explanation send me your perceptually uniform colormaps please and frequently find myself pushing the limits of plotting libraries or even writing my own algorithms . I love presenting my work to both technical and non technical audiences and collaborating wherever possible . Technology stack includes Python , R , Java , Javascript , C , C , SQL , Git , Jupyter , Unix .. Technologies :",
"Post doctoral researcher . After my PhD on tau protein misfolding in the presence of zinc , I decided to continue studying proteins folding with my first post doc focused on Hsp90 and the protein translocation machinery . Giving the high proportion of crossing membranes proteins in cell including membrane proteins , organelles proteins or secreted proteins , the translocation phenomenon appears to be crucial in cell life . It maintains proteins in a unfolded state in order to allow their delivery through the membranes , after which they ensure their functions . The aim of my post doctoral work is to elucidate the molecular events leading to the translocation of proteins from the cytosol to the inside of organelles such as mitochondria or chloroplast . For this purpose , I will express and purify protein complexes before performing crystallography and or cryo EM structure analysis , while carrying out functional assays , in order to understand how each actor can be a part of this complex machinery . . I 'm ready to try any experience that can improve my knowledge about biochemistry or biology . Technologies : CryoEM",membrane proteins;proteins;expression;stability;structure
"Assistant Professor . . Google Scholar page with actual publications : https : bit.ly 3fYk4R4 My current research focuses on quantitative mass spectrometry using isobaric TMT labeling and in vivo proximity labeling techniques to study drug induced biological processes in immune checkpoint receptor signaling , GPCR signaling and beta adrenergic signaling in the heart . I lead an independent research lab at MD Anderson Cancer Center applying cutting edge mass spectrometry and I have been training and educating students , scientists and other faculty on experimental design , procedures and data analysis .. Technologies :",
"Senior Director , Head of Advanced Analytics , Experimental Medicine Unit . . . Technologies :",
Group Leader . We study structures of medically important membrane proteins and their complexes with the modern methods of cryo electron microscopy and tomography . For the recent list of papers : https : scholar.google.com citations sortby pubdate hl en user Rg40N1UAAAAJ Twitter : https : twitter.com kudryashev lab . . Technologies : CryoEM,membrane proteins;structure
Scientist I Computational Biology . . Interested towards research and development in the field of Computational Biology and Bioinformatics which uses computer science applications to describe biological phenomena . Specifically Interested towards computational modelling of protein structures and functions . . Technologies :,
"Director Of Bioinformatics . . Results driven individual with a strong track record of excelling in team environments . Passionate about technology , science , and the environment .. Technologies :",
"Professional Research Assistant . Professional research assistant PRA in the Aydin Lab focusing on mitochondrial protein complexes . Current work involves optimizing a membrane protein expression protocol in yeast cells and using cryo EM to characterize the structures of several mitochondrial proteases . . I am Bates College graduate who majored in biology and minored in chemistry . While I previously went to school in Maine , I was born and raised in Taipei , Taiwan . My family moved to the United States in 2009 looking for better career and education opportunities which ultimately inspired me to be a pre medicine student in college . I am currently working as a professional research assistant PRA at a structural biology cryo EM lab at CU Boulder . My goal is to attend either medical or graduate school in the near future .. Technologies : CryoEM",proteins;structure
Associate Director of Quantitative Pharmacology . . . Technologies :,
"Senior Bioinformatics Scientist . . Data Scientist Engineer and Computational Biologist . Ph.D. in Neuroscience . Leads Software and Data Science team at ChromoLogic Covisus , with a focus in computer vision and biotechnology . Passionate about the intersection of innovative methods , the technical platforms to support them , and the new scientific insights they enable . Everyday tools include Python , R , Docker , Git , Linux , and emacs . Strong background in SQL PostgreSQL , statistical inference , software design , and device design . Also familiar with C C , Java , JavaScript , Haskell , Rust , Scheme , ELisp , and other languages .. Technologies :",
". . Creative , enthusiastic and self motivated individual with years of experience in multicultural environments . Highly skilled protein biochemist , with a strong background in membrane proteins , metalloproteins , and bioenergetics . Excellent team player and collaborator in multiple projects leading to eleven peer reviewed publications and a few more in various stages of preparation . Creative problem solving , troubleshooting , establishment and adaptation of protocols , Design of Experiments based approach . Project management . Ability to formulate hypotheses and ideas for experiments from literature and knowledge inputs . Presentation skills , literature reviews , grant and proposal writing inc . three NIH grant proposals . Communication , collaboration and training supervision . Scripting Python , R for data analysis , modern statistical methods , data visualizations . Graphic design for scientific purposes Adobe Photoshop , Illustrator , InDesign . Biochemistry and Structural Biology expertise : Protein production and purification : target design , cloning , expression screens native and heterologous , prokaryotic and eukaryotic ; 96 well plates , scaling up to liters . DoE based large scale screens , cell cultures . Trafficking analysis , isolation including detergent screens , purification classical methods , FPLC , post expression manipulation proteolytic cleavage , labelling , glycosylation analysis . Stability methods SLS DLS , DSF , ITC , CD , electron microscopy , analytical centrifugation , custom fluorescence assays , size exclusion chromatography of labeled label free proteins . Affinity assays western and dot blots , ITC , pull down assays , intrinsic fluorescence and fluorescent labeling , NMR . Protein protein interactions . Enzymology e.g. nitrogen reduction assays , redox reactions and ion transport . Extensive knowledge in protein lipids interactions , in solution and in reconstituted systems . In vivo assays fluorescence , survival assays , whole cell NMR , confocal fluorescent microscopy . X ray crystallography : vapor diffusion , lipidic cubic phase , detergent lipid micelles . Sample preparation for cryo EM .. Technologies : Xray;CryoEM;ITC;SLS DLS;DSF;NMR",membrane proteins;stability;expression
"Postdoctoral Researcher . . Senior scientist with extensive experience in the investigation of protein : RNA complexes , including recombinant protein expression in bacteria or eukaryotic cells , synthesis and purification of nucleic acids , all common structural biology techniques X ray crystallography , NMR and Cryo EM , and functional characterization in vivo and in vitro .. Technologies : Xray;CryoEM;NMR",nucleic acids;proteins;characterization;expression;interaction;structure
"Honors Thesis Research . Independent Honors Thesis research working with mentors from MDI Biological Laboratory studying gene expression in the regenerating tail fin of zebrafish . In this project we are investigating the potential to identify specific cell type responses in cortisol treated adult zebrafish bulk RNASeq data Hartig et . al . 2016 by using the gene lists for specific cell types from sc RNAseq data Hou et . al . 2020 . . Experienced bioinformatics scientist and manager with a demonstrated history of working in the bio science and computer software research fields . Skilled in Linux Command Line , Python , GitHub , genomic analysis tools , PyCharm , Microsoft Office Suite , C , HTML , CSS , and Markdown . A skilled and organized leader who is always eager to learn new tools and can work well in a team . Strong professional with a Bachelor of Arts BA focused in Bioinformatics from Wheaton College in Norton , Massachusetts .. Technologies :",
"Senior Scientist I , Computational Biology . . A bioinformatics researcher aspiring to improve healthcare through the integration of genomics and data science . I use computational and statistical methods such as machine learning , high performance computing , and biological systems modeling to drive genomic biomarker discovery , and clinical decision support . I hold a PhD in Electrical and Computer Engineering with an emphasis in Genomics and Healthcare Informatics .. Technologies :",
"Head , ShinrAI Center for Artificial Intelligence Machine Learning . . Senior pharma biotech executive with strengths in leveraging data analytics and generating innovative ideas to develop solutions for drug discovery and development . Succeed in blending systems and strategic thinking , people engagement capabilities , with hands on technical skills in tackling complex issues . Experience and accomplishments in : Building and mentoring high performing teams Delivering scientific and technical depth Translating ideas into products Influencing and driving changes Recognizing untapped opportunities Scaling operations Technical interest : predictive modeling in service of reducing time and cost of drug discovery .. Technologies :",
Group Leader . 2004 2012 : Cryo EM facility manager Since 2013 : Head of Scientific Microscopy and Cryo Electron Microscopy Service Group . . Technologies : CryoEM,proteins;structure
"Validation Scientist QA . Method validation in enzyme production processes Support in performing risk analyses Reviewing standard operation procedures and process validation documents . Focus in upstream downstream processing , biophysical characterization , protein engineering and protein bio chemistry . Technologies :",enzymes;characterization;engineering;quality
"Senior Scientist II . . Computational scientist focused on drug discovery . Experienced in cheminformatics and computer aided drug discovery methods , scientific software development , and statistical modeling machine learning . Experienced in coding scientific and web applications with Python , C , Java , Fortran , JS , and SQL , and using chemical modeling software including Schr dinger , Gaussian , AMBER , and PyMOL . . Technologies :",
"Research Laboratory Technician 1 . Currently working for the Stamatatos Pancera Lab at Fred Hutch , investigating the structural characteristics of HIV , Malaria , and opioid vaccines through x ray crystallography and emerging Cryo EM techniques . . I work within the Pancera Lab group at Fred Hutch CRC as a Research Technician , with a focus on structural determination and structure guided design . Our projects are closely tied to the Stamatatos lab , which is currently studying novel HIV therapeutics such as anti idiotypic mAbs and VRC01 class antibody maturation through structure guided vaccine design . We also focus on independent structural projects across a variety of other diseases including malaria , HPV , HPIV , RSV , and opioid addiction . My experiences within the Pancera Stamatatos lab have allowed me to grow and refine my skills with various cloning methods , protein expression in mammalian cells and purification , and protein assaying with BLI technology . Additionally , I have worked on and greatly increased my knowledge of x ray crystallography , along with emerging cryo EM technologies , to gather structural data on difficult proteins across a variety of sources . I also have a background in information and theater technology , as well as publishing , finances , project management , and photography . I am also an experienced DnD GM of 6 years , with an interest in novel world creation and unique theological designs . Overall , I am a nerd who enjoys finding new interests in everything I encounter , and as a worker , I always try to bring enthusiasm , adaptability , and a learn to overcome attitude to any job I 'm faced with . Technologies : Xray;CryoEM;BLI",antibodies;biologics;proteins;interaction;structure
"Principal Scientist , Life Science Chemistry , Project Leader and Lab Head at Innovation Campus Berlin . Leading integrated drug discovery projects in . Gynecological Therapies . Managed external chemistry capacities . 20 years experiences in pharmaceutical industry with strong expertise in Medicinal Chemistry , Hit to Lead , Fragment to Lead and Lead Optimization . Experiences with covalent inhibitors , PROTACS , DNA encoded library . Current interests include new modalities and innovative therapies . Technologies :",molecular glues;small molecules;screening
"Vice President , Head of Process R D Pharmaceuticals . Responsible for process development of active ingredients for all pre clinical and clinical trials worldwide . Managing and developing a center of excellence for process chemistry , including : State of the art manufacturing processes , generation of process related IP , ensuring low cost of goods and sustainability , delivery on short development timelines ; the responsibility covers small molecules as well as synthetic new modalities e.g. PROTACs , RNA targeting SMOLs , peptides , bioconjugates , and radiopharmaceuticals . Responsible for people development of 30 scientists and driving strategic initiatives . . Head of Process R D and chemist by education . Background of 15y in ag and pharmaceutical industry R D. Passionate about life science and advancing innovation to help solve significant challenges of modern society . Experienced in devising R D strategies in multiple areas e.g. data science , open innovation , science governance and levels corporate , divisional , functional . Experienced in managing diverse research project portfolios SMOL , ADC , thorium conjugates with a track record of successfully advancing novel drug candidates into clinical development . Broad expertise in running research collaborations with both academic and biotech partners . Team player with strong communication leadership skills and expertise in talent development as well as in building empowered high performance teams . Key expertise : Medicinal chemistry , open Innovation , data science , Antibody Drug Conjugates ADC , crop protection , R D strategy . Technologies :",molecular glues;small molecules;peptides;developing
"Chemist process support . Chemist process support Process support in Product Supply Biopharm within the New Hemophilia area . Responsible for support to the cultivation of mammalian cell production . Daily support to a production environment with fast changing focus areas . Handling of deviations , change requests , validations reports , and other GMP related cases with a focus on a strong quality and compliance mindset . Systematic problem solving including root cause analysis to ensure prevention of deviations . Optimization of work processes both small and largescale . Compilation of Standard Operating Procedures SOP with a focus on the enduser . Participation in interdisciplinary projects . Responsible for tech transfer from development to production scale . . Cand . Scient with both practical laboratory experience and GMP experience from the biopharmaceutical industry . I have a curious mindset and always seek to understand and improve within my field of work whether it be in research and development , or a production setting . I hold a master s degree in biology and Biotechnology from the University of Copenhagen . My time at the university has given me theoretical and practical experience within several fields of Biotechnology such as microbiology , biochemistry , cloning , cell culture handling , protein expression and purification , protein characterization , bioinformatics , and statistics . My master thesis and time as a research assistant was spent planning and executing research projects revolving around expressing and characterizing novel membrane proteins in model systems , followed by characterization of said proteins . After my time at the university , I joined Novo Nordisk to develop my skills towards the biopharmaceutical industry where I currently work with API production in mammalian cells on a large scale level . My responsibilities include SME , process optimization , troubleshooting , writing of official documents such as deviations and change requests , training , and project participation . Noteworthy projects include facility rebuilding including design and validation and technology transfer from development to production scale . . Technologies :",
"Senior Scientist . . Enthusiastic Computer Science doctorate candidate with 6 years of research experience and strong publication record , focused on the development , application , and comparative analysis of computational methods for biological sequencing data . . Technologies :",
"Associate Principal Scientist , Computational Structural Chemistry . . Highly motivated structural biologist with 15 combined years of experience in academia and industry . Expert in the structural biology X ray crystallography and cryo EM of both soluble and membrane proteins with a focus on structure based drug design .. Technologies : Xray;CryoEM",
"Group Leader , Enzyme Analytical Lab QC . People Management Coaching , target setting evaluation and carrying out monthly Performance and Development Dialogues with 15 technicians . Guide and motivate the team as both individuals and a team to meet KPI s growth objectives , e.g. reduce analytical red runs , Right First Time analysis , Right In Time system batch releases . Project Management Good time and project management skills to organise , plan and manage QC analyses of all Novozymes products in cGxP set up effectively . Daily planning with two other groups of the 120 available in house analyses , incorporating ad hoc complaint samples and deviation studies , while never fails to meet the maximum 5 day response time to all our customers . Quality Management cGxP compliance activities including audit , implement , deviations and ISO9001 certified . Working with CMO , logistics , production QA RA on complaints , reprocesses , change controls and recalls Communication Feed forward communication with the stakeholders in anticipating new products , services or tools to drive ad hoc demands in future projects , e.g. tailor made analytical solutions for new potential projects . Good customer negotiation skill in hammering out a mutual agreement dateline , sample size , etc . Continuous Improvement Daily continuous improvement on daily processes operations safety . Formulate long term business goals , strategies , action plans and training programs with other departments , e.g. drive external supply chain with more robust API supply accounting for spec deviation . Monitor and ensure if not good , acceptable HSE levels in workplace . . Analytical Solid : spectro , DSC TG , XRD , elasticity Liquid : uHPLC , HPLC , IC , KF , GC , MS , NMR Particle : micronisation , milling PSD Suspension : density , dissolution , solubility Stability studies : DS , DP medical devices IT tools LIMS MS Analytical software : Super user Continuous Improvement RCA 5S LEAN : Manager Six Sigma : Yellow Belt Global Quality CMC spec CMC strategy RA QA QC documentation cGxP : compliance validation activities Internal External audits Environment standards regulation ICH , EMA FDA Patent filing strategy Complaints Languages English 5 5 Mandarin 4 5 Dutch 4 5 Danish 3 5 Presentation skills 4 5 R D Work Experience 10 years experience with Research Discovery Med Chem support , Analytical , Scale Up 8 years experience with Development Process Development , Technology Transfer , GMP DS DP , Patent , RA QA QC 8 years experience with Commercial Production Intermediate , API , DP . Technologies : DSC;NMR",
"Senior Principal ML Researcher . . Experienced Researcher with a demonstrated history of working in the higher education and industry . Skilled in Machine Learning , Bioinformatics , R , C , and sc RNA seq data analysis . Strong research professional with a Doctor of Philosophy PhD focused in Computer Engineering from The University of Texas at Dallas . . Technologies :",
"Senior Scientist . . As a specialist in Molecular Pharmacology , I am working on the identification of novel therapeutic targets to treat chronic pain by understanding its underlying molecular mechanisms . . Coupled with my experience in using preclinical rodent models of neurological conditions , I am looking forward to expanding my horizons in neuroscience research , especially to work in a leadership role to support patient care and clinical research . . Special emphasis of my career has been on genome wide studies and non coding RNAs . . My contributions lead to the discovery of several novel molecular mediators in the chronic pain modulation and a patent application . . I am a certified professional in project management , personnel management , and drug discovery . . I demonstrated leadership via ongoing publications as lead author , developing novel research ideas , acquiring research funding , supervising students from bachelors to Ph . D. levels , peer reviewing for scientific journals and funding agencies , organizing workshops and webinars and presenting invited seminars at international conferences of repute . . As part of my current job profile , I manage research projects funded by national and international organizations viz . the American Institute for Cancer Research AICR , European Commission EC , and German Research Foundation DFG . Few of my Key competencies : . Pharmacology . Pain models . Drug delivery . in vivo and in vitro RNA interference RNAi . Translational biology . non coding RNA . microRNA miRNA . long non coding RNA lncRNA . Gene editing technologies . Systems biology . OMICS technologies . Preclinical rodent models . Genome wide screening . in situ hybridization ISH . qRT PCR . Mammalian cell line development and culture . Cloning and expression in bacterial systems . Standardization of experimental protocols . Project management . Laboratory management . Supervision of personnel . Scientific and technical communications . Technologies :",
"Scientist Protein Chemistry . . Research scientist with a PhD in Biological Sciences awarded by the University of Cambridge UK . Research experience in purification of large protein complexes , kinase activity assay , hydrogen deuterium exchange mass spectrometry and structure determination by cryo electron microscopy . Fluent in spoken and written English and experienced in writing as well as presenting scientific data . . Technologies : CryoEM",proteins;structure
"Scientific Growth Manager Cryo EM Scientist . . I am a researcher passionate about understanding the molecular mechanisms of aging and disease . My experience spans both membrane protein biochemistry and biophysics , as well as molecular genetics . This versatile background has given me a broad view that allows me to solve problems creatively by combining different fields and methods of approach . I have had projects around Europe , and believe science reaches its highest potential via dedication in diverse networks .. Technologies :",proteins;characterization;structure
"Scientist , Quantitative Pharmacology . . Years of experience in modeling and simulation of biological systems and complex cellular pathways , PKPD and QSP modeling .. Technologies :",
"Director Medicinal Chemistry . Co lead of medicinal chemistry department in Darmstadt , coaching mentoring of individuals and teams , responsible for people development and oversight of research projects within portfolio , lead of global fragment expert team and lead of strategic change initiatives . . Experienced project lead with a demonstrated history of research projects in the area of immunology , oncology and immuno oncology . Skilled in medicinal chemistry , organic synthesis , fragment based drug discovery and all aspects of drug design from hit discovery to entering clinical development . Strong leadership , communication , mentoring coaching skills demonstrated with individuals and teams . PhD and postdoc in natural product synthesis . passionate about new concepts , target classes and hit identification technologies and helping individuals and teams to perform at their best . . Technologies :",small molecules;interaction
"PHD Student . Pursuing my doctoral studies on genome transcription and regulation in the lab of Patrick Cramer . To this end , we employ structural i.e. cryo EM and biochemical approaches for such purposes . . . Technologies : CryoEM",nucleic acids;structure
Principal Scientist . . . Technologies :,
"Principal Scientist in computational biology and human genetics . . 20 years experience of programming in research environment . 10 years experience in computational biology , bioinformatics , analysis of next generation sequencing data , cancer genomics , statistical data analysis . PhD in theoretical physics .. Technologies :",
"Bioinformatics Scientist . Developed a Nextflow pipeline for processing single cell RNA sequencing with key features such as the ability to run in both a high performance computing cluster environment and an Amazon Web Services environment , the ability to start from any step in the workflow , and the ability to also handle feature barcoding samples and immune profiling samples . Pipeline is being used to automate data processing for thousands of samples across numerous therapeutic areas . Collaborated with lab scientists to develop a workflow for single cell CRISPR sequencing processed multiple internal external datasets and then presented my findings to the group , providing feedback on experiments . Additionally explored and compared tools for downstream analysis of single cell CRISPR sequencing data . Stabilized a Nextflow pipeline for metagenomics data so that it could run without error in multiple environments . . Published author and computational biology graduate with over four years of work experience in academia and industry . Experienced in developing automated data processing pipelines in Nextflow for next generation sequencing data . Proven ability in data analysis , data visualization , and programming , particularly in R and Python . Proficient in Git version control , grid computing with Grid Engine , cloud computing with Amazon Web Services , and containerization with Docker and Singularity . Results oriented team player capable of working both independently and in cross functional , interdisciplinary teams . Developed and published a R software package , AssessORF , which is available through Bioconductor .. Technologies :",
"Sr . Principal Scientist , Bioinformatics . . Highly motivated bioinformatics professional with 14 years experience working in Genome Annotation group involving analysis of high throughput NGS data , annotation of bacterial and fungal genomes , modelling , prototyping and automating annotation pipelines with extensive use of Bioinformatics tools . Good Project Management skills involve working with Collaborators and Project Scientists . Specialties : Genome Annotation of Prokaryotic and Eukaryotic genomes Develop novel annotation protocols and automated pipelines Develop , test and evaluate Bioinformatics tools Process and Integrate RNA seq data using Samtools , BWA etc Interpret and analyze large volumes of data Project Management to coordinate and manage group projects Working with Project Scientists and Collaborators Scripting in Python , Jython , Ruby , Shell , HQL , SQL , R. Technologies :",
"Staff Bioinformatics Scientist . . I am motivated by using machine learning to leverage the information in biological datasets , in order to make discoveries and inform products in the space of computational biology , genomics and medicine . Please also see my website for more information : https : www.cs.cmu.edu jingx . Technologies :",
"Senior Scientist . Chemical Biology Therapeutics CBT ; Screening Sciences . Platform internalization of Nuevolution Kopenhagen , Denmark DNA encoded chemical libraries DEL technology to Novartis . In charge of project management for regular DEL selections against a broad variety of protein targets and method development in collaboration with international colleagues from different divisions . Discovery of therapeutic small molecule leads within nucleic acid encoded libraries . . Senior Scientist developing and implementing several innovative research technologies such as DNA encoded chemical libraries DEL , high throughput screening HTS and label free technologies biophysics for drug discovery projects . Technologies :",proteins;small molecules;screening
"Senior Scientist , Machine Guided Design . . PhD in Systems Biology from Columbia University , where I developed computational methods to extract interpretable biological signal from large , high dimension single cell RNA sequencing scRNA seq datasets and worked at every level of scRNA seq data processing , quality control , and analysis . Highlights : Developed an applied machine learning method to find interpretable latent structure in large , high dimensional scRNA seq datasets , with accompanying open source software Levitin et al . 2019 . Collaborated with experimentalists to construct a single cell reference map of T cell activation across human tissues Szabo , Levitin et al . 2019 . Identified a novel pan T cell activation marker and a previously undescribed temporal intermediate in CD4 T cell activation .. Technologies :",
"Doctoral Candidate . Primary Advisor : Dr. Chittaranjan Das Quantified and characterized protein activity utilizing various biochemical and biophysical techniques . Used cryo Electron Microscopy for structure solution of larger molecular assemblies of pathogenic effectors . Developed activity assays to monitor protein function using fluorescent probe incorporation . . Experienced ambassador to various departments , with a passion to fight for diversity , equity , and inclusion in higher education . Multiple experiences in leadership , fundraising , and mentorship . Strong operational skills in biophysical chemistry , with a focus in cryo EM and the ubiquitin signaling pathway . Received Bachelor s Degree with highest distinction in chemistry from Purdue University 2018 , Currently pursuing a PhD degree expected May 2023 .. Technologies : CryoEM",proteins;characterization;structure
"Bioinformatician . . Experienced Bioinformatician with a demonstrated history of working in the hospital health care industry . Skilled in Statistical Data Analysis , Data Analytics Development , Analytical Insight Generation , Research and Development R D . Strong research professional with Biomathematics and Complex Systems backgrounds , modeling of Economic Evaluations of Health Interventions and Systemic approaches . Throughout my career I have received awards from the National Autonomous University of Mexico , the Botanical Society of Mexico , the pharmaceutical industry and from two distinct areas of the Secretary of Health of Mexico .. Technologies :",
"Sr . Bioinformatics Software Engineer . . I am a scientist who specializes in bioinformatics , data science and software engineering . I design and implement bioinformatics pipelines where the software is subject to regulatory agencies such as the FDA or CLIA and require a high quality , documentation , and software engineering best practices . I believe that the research and engineering used to implement the research are intimately linked and work to become an expert on both sides of the equation to get the highest quality research as well as software implementing the research . My current work is in a small team researching , designing , documenting and implementing a fully automated and robust analysis pipeline that selects the neoantigens to included in a Personalized Cancer Vaccine currently in a Phase 1 trial . Prior to that I was in charge of migrating a fully automated targeted NGS sequencing carrier screening assay from local hardware onto Amazon Web Services as well as a variety of data science and analysis tasks in support of a CLIA regulated lab . Specialties : Bioinformatics , IND , Immuno oncology , Personalized Cancer Vaccines , Neoantigens , Regulated Software FDA and CLIA , Change Control , Next Gen Sequencing Analysis , Cloud Compute , Cluster Computing , Sun Grid Engine , Amazon Web Services , EC2 , S3 , Starcluster , Tableau , Luigi , AWS Lambda , Cluster Optimization .. Technologies :",
"Senior Bioinformatics Data Scientist . . Passionate about bridging the gap between life science challenges and technical solutions , making scientists life easier and empowering them to get more out of their data . Technologies :",
"Staff Computational Biologist . . Leader in computational biology and product development with cross functional experience and an entrepreneurial mindset . Proven ability to deliver value by enabling data driven decisions all the way from product development to scientific applications . Skills : 1 . Computational biology : single cell genomics , DNA RNA design , NGS assay development , statistical inference from multi modal biological data 2 . Tech leadership : milestones for SW development ; code reviews and developer mentoring ; sprint planning and execution . Python advanced , R intermediate 3 . Science : CRISPR perturbations , gene expression , transcriptional regulation , DNA RNA biophysics 4 . SW product : SW UI UX and design choices , mockups and wireframes , customer interviews , sprint planning and execution 5 . Leadership : recruiting , motivating , and leading teams ; communication grounded in empathy . Technologies :",
"Sr . Scientist . Lead multi disciplinary and cross functional teams to develop meaningful therapeutics for patients with cardiac or metabolic diseases Identify novel therapeutic targets based on new insights in human genetics Broad experience with small molecule , antibody , and siRNA therapeutics Targeted protein degradation through induced proximity via the ubiquitin proteasome pathway Genome editing , disease modeling , and functional characterization using human induced pluripotent stem cell derived cardiomyocytes . A strong ideator and project leader in identifying , validating , and advancing targets in multiple cardio metabolic disease areas , including NASH , cardiac hepatic fibrosis , and heart failure Broad experience with a variety of therapeutic modalities , including siRNA , antibody , and small molecule protein degrader Lead cross functional project teams , mentor supervise scientists interns A proven protein biochemist and molecular cellular biologist with extensive experience in protein biochemistry , post translational modification and cell signaling Outstanding publication record 1st author publications in Science , eLife PNAS and additional papers in Nature Cell . Technologies :",antibodies;molecular glues;nucleic acids;small molecules;developing
"Associate Director , Computational Biology . . . Technologies :",
"DPhil Candidate , Computational Biology . Advisor : Emeritus Professor Mark S. P. Sansom Funded by the Skaggs Oxford Scholarship and the Croucher Scholarship for Doctoral Study Notable Research Activities : Biophysical Society 64th Annual Meeting 02 2020 , San Diego Poster Award Gordon Research Conference on Mechanisms of Membrane Transport 06 2019 , New London NH Cold Spring Harbor Asia Conference on Membrane Proteins 05 2019 , Suzhou Poster Award University of Copenhagen Ion Channel Symposium 05 2019 , Copenhagen Biophysical Society 63rd Annual Meeting 03 2019 , Baltimore Force gated Channels : Physiology , Regulation Function 10 2018 , Berlin International Workshop on Biological Membranes : Tiny Lipids with Grand Functions 08 2018 , Helsinki Biochemical Society : Structure and Mechanisms of Membrane Proteins 08 2018 , Birmingham British Biophysical Society Biennial Meeting 07 2018 , Southampton . I am a joint doctoral student between the University of Oxford and Scripps Research California , reading for a DPhil in Biochemistry and a PhD in Biology . My research combines dry computational and wet experimental lab techniques to elucidate the molecular mechanism of membrane proteins . I am also passionate about serving the graduate community I am in , communicating science and promoting tertiary level STEM education in Hong Kong . Currently , I serve as a Layout Editor of Phenotype Journal , Vice Presidents of the Graduate Student Council GSC and Scientific Diversity Association SDA at Scripps Research . I previously served as the the Co President of the Oxford University Biochemical Society OUBS and the President of the Oxford University Hong Kong Scholars Association OxHKScholars . A more detailed description of my research career can be found at my scholar 's profile on Croucher Foundation 's website https : scholars.croucher.org.hk scholars alex tsui I 'm also a wine enthusiast outside of work , currently working towards the WSET Diploma in Wines 4 of 6 units completed , all with Distinction , 1 . I am also a SSI Certified Sake Sommelier and a Certified Specialist of Sherry Wines .. Technologies :",membrane proteins;characterization
"Principal Scientist , Computational Biology and Protein Design . Synthekine is a development stage biotherapeutics company focused on the engineering of novel specific , selective and potent cytokine therapies . Our targeted protein engineering guided by our deep experience in immunology provides transformative immunotherapies for the treatment of cancer and autoimmune disorders . . Computational biologist with an extraordinary breadth of knowledge and experience across numerous computational , structural and bioinformatic domains including protein design , protein ligand and protein protein interactions , and the molecular dynamics of biochemical and macromolecular systems . Applied use and development of supervised , semi supervised and unsupervised machine learning and deep learning methods and models , and the creation , use and analysis of large scale omics datasets . Extensive experience recruiting , working with and managing diverse groups of scientists and programmers from all segments of biomedical research combined with expertise in the experimental and analytical methods of biomedical data collection and generation . In depth , hands on experience with early stage biotech startups , executive , board and investor relations , strategic planning and business development .. Technologies :",
"Associate Computational Biologist . Working in single cell genomics at the Villani Lab , housed within the Center for Immunology and Inflammatory Diseases CIID Massachusetts General Hospital and associated with the Broad Institute of Harvard and MIT . Day to day involves working on conceiving and applying algorithms as well as analytical approaches to analyze single cell RNA DNA protein ATAC sequencing sequencing data generated from a wide range of human tissue and immune related disease conditions , with an excellent team of physician scientists , post docs , clinicians , computational scientists and RAs . . Biomedical Engineer with a minor in Computer Science working in computational biology , with relevant experience in computational modeling , computer vision , bioinformatics , tissue engineering scaffold characterization and optimization , and neural stem cell cultures , neurodegenerative diseases , and inflammation . Proficient in stem cell culture , immunofluorescence , protein and nucleic acid assays , deep learning , writing data processing and visualization packages , R , MATLAB , C , ImageJ Macro development , and python . Interests include public speaking and debate US Universities Debating Championship Semifinalists , painting , politics , and Real Madrid .. Technologies :",
"Senior Principal Scientist BioNMR Team Lead . . Extensive biomolecular NMR , biophysical , and analytical experience to support a modality agnostic approach to drug discovery in pharmaceutical research . Successfully implemented innovative NMR based drug discovery tools and approaches for the discovery of small molecule leads at SPRI Merck . Highly experienced in all aspects of biomolecular NMR spectroscopy and Fragment Based Lead Discovery FBLD ; extensive knowledge of biophysical characterization of protein ligand interactions and biological processes associated with drug discovery ; proven track record of decisive leadership , team work , interdisciplinary collaboration and scientific innovation in pharmaceutical research ; possessing outstanding interpersonal skills .. Technologies : NMR",proteins;small molecules;characterization;interaction;screening
"Principal Scientist , Downstream Process Assessment in Biotherapeutics Integrated Biology Departmen . Provide and apply expertise in protein expression and purification for target proteins from E.coli , baculovirus , and mammalian expression system using affinity , IEX , HIC.isoelectrofocusing chromatography and SEC with common or specialized resins . Develop working knowledge expertise of all biophysical protein characterization tools CD , DLS , HPLC , MOLS and AUC and applied to more than 80 purified proteins . Demonstrate additional scientific knowledgr of projects and understand technology beyond protein purification . Maintains scientific excellence in area of protein biochemistry . . Responsible for construct design , molecular cloning , expression , and purification to support HTS small molecule lead discovery , high throughput cloning and expression initiative , and biologic drug discoveries within immunology inflammation and cardiometabolic disease areas . Coordinate all outsoursing activities for the mammalian protein expression and purification for both therapeutics areas . Expertise in improvement of enzyme catalytic properties for pharmaceutical industry applications cGMP environment , including direct enzyme evolution and enzyme engineering . Extensive experience in improvement of recombinant protein expression in E. Coli systems cDNA cloning and subcloning . Purification of soluble and refolded proteins through cell subfractionation and various types of column chromatography , anion exchange , HIC , SEC , affinity chromatography HPLC , FPLC AKTA and Pilot AKTA . Expertise in nucleic acid purification and separation . Developed libraries for different enzymes mostly for R and S Transaminases for chiral amine and chiral ketone production using error prone PCR and site direct mutagenesis . Designed screening methods for isolating suitable mutant enzymes from the library . Screened Luciferases for improved properties for application in vitro cell based assay cAMP assay and protein kinase and adenilate kinase assays in GPCR area Obtained enzymatic characteristics of each mutant enzyme using biocatalysis and kinetic parameters . Validation of Adenosine Triphosphate cytotoxicity assay in Normal Human Epidermal Keratinocytes Working knowledge of cGMP and other regulations controlling the work processes in pharmaceutical industry R D. Managed team of four biochemists on multiple projects , the majority of which were assay development , protein purification , and enzyme evolution by cloning and subcloning . Specialties : Biochemistry , molecular biology , cell biology , signal transduction , enzyme assays .. Technologies : SLS DLS;AUC",antibodies;enzymes;proteins;small molecules;characterization;engineering;expression;screening
"CAR T Scientist . . A respected , resourceful multilingual Scientist showcasing a solid molecular biology and biotechnology background in addition to a passion and knowledge within drug development . I am further recognized as a motivational , influential leader and collaborator who enjoys guiding high performing teams within matrix environments in performing significant research projects , achieving complete compliance . I am also an out of the box thinker with a passion for driving continuous improvements using CAPA Lean 8D practices and leading key initiatives to deliver on all goals . I have been promoted to positions of increasing authority and responsibility due to my strong leadership skills and overall performance . I possess exceptional academic qualifications including a Doctor of Philosophy in Cell Molecular Biology from the University of the Sciences in Philadelphia and a Master of Science in Biotechnology from the University of Mumbai . Summary : Energetic strategic thinking scientific researcher with a strong background small molecule drug discovery and biomarker analysis with a proven track record of publications . Excellent mentor , seasoned team player and participant of productive collaborations in various aspects of basic research projects .. Technologies :",biologics;small molecules;screening
"Associate Director , Data Science . . Experienced researcher with a long work path in computational simulations . Skilled in molecular biology , chemistry , python , bioinformatics , biopolymer theory , systems administration , scientific programming . Strong research professional with a PhD focused in RNA structure and bioinformatics from Rutgers , The State University of New Jersey New Brunswick . Expert in GPCR 's , RNA , DNA and protein simulations .. Technologies :",
"Senior Scientist II Crystallography at Sosei Heptares . . Experienced structural biologist , biochemist . Specializing in membrane proteins , including GPCRs and transporters . Utilizing structural studies on protein ligand complexes to aid pharmaceutical drug discovery and development . Specialized skills including protein expression in E.coli , yeast and insect cells , purification , biophysical characterization , crystallization vapor diffusion and LCP and protein structure solving via X ray crystallography .. Technologies : Xray",membrane proteins;interaction;structure
Senior Research Scientist Bioinformatics . . . Technologies :,
"Senior Director Head of Discovery Technologies . . Accomplished scientist with 10 years of drug discovery experience in academia and biotech . Strong background in cancer biology , genetics , and protein homeostasis . Expertise in target identification , lead discovery , and building innovative technology platforms . Highly creative scientist with an entrepreneurial mindset and proven track record of leading and executing challenging drug discovery programs . Currently leading the biology efforts to build and develop a Molecular Glue platform harnessing the ubiquitin proteasome machinery for undruggable targets degradation in oncology and beyond . Technologies :",molecular glues;interaction
"BIoinformatics Principal Programmer Analyst . . Biology : Special interest in all aspects of biorepositories for cell line , human and microbial collections . Pioneer in biological object modeling and design of biotech research discovery protein pipelines serving 2000 scientists . Especially focused on personalized medicine crafting genome phenome data synthesis environments . Management : Extensive experience and enjoyment of people , project , and international team management . Strong advocate of women in science and engineering . Original design of research molecule portfolio management and executive decision archives . Software engineering : Chair of the Research Bioinformatics and Computational Biology Steering Committee . Established SFSU computer science student affiliation . Decades of database and web application development . Prefer rapid search engines , cool data visualization and software usability . . Technologies :",
"Chief Statistician . Leading statistician on multiple phase I II III projects on oncology , dermatology and respiratory , and have contributed for 10 drugs market approvals including treatments for COVID 19 , Diabetes and COPD . As a committee member of GLOBAL MEDICAL AFFAIRS SYNOPSIS REVIEW GROUP , review and approve clinical synopsis for all clinical studies worldwide . Supervise CROs to deliver study results on time after database lock with high quality and compliant to regulatory submission of Final TLFs . Provide statistical input on the Clinical Development Plan CDP : Study design , sample size calculation , protocol , SAP , and CSR . Suggest and implement innovative Bayesian approach during the clinical trial design . Apply data mining strategy to dig import informstion from hudge historical clinical studies data by saving a new phase4 study with thousands of patients . . An enthusiastic and passionate expert in consultancy data analysis and algorithm development . 20 years in statistics . Effectively initiates and communicates methodology , constantly meeting challenges . A creative , strong and hard working matrix team player , energized by challenges . Specialties : Leading statistician for clinical studies leading to marketing approval of 22 drugs A list of 55 peer reviewed publications in statistics and multivariate data mining method development Biostatistics , Bayesian Statistics , Mixed Effect Modelling In partnership with FDA , authored chapter of Chemometrics and predictive modelling in the book Nonclinical Biostatistics for Pharmaceutical and Biotechnology Industries , Springer Science Business Media , 2016 . http : rd.springer.com chapter 10.1007 978 3 319 23558 5 25 . In Feb 2021 , initiated the NONS as a strategy product to fight against different VOCs of covid19 , leading phase 3 study design , data analysis and interpretation , which resulted to the NONS accelerated market approval by GCGI in Feb 2022 , and a paper in the Lancet , widely covered by media , featuring in around 200 publications . https : www.thelancet.com journals lansea article PIIS2772 3682 22 00046 4 fulltext Monika Tandon ; Wen Wu ; Keith Moore ; Stephen Winchester ; Yuan Po Tu ; Chris Miller ; Rahul Ramesh Kodgule ; Amol Pendse ; Shabbir Rangwala , SARS CoV 2 Accelerated Clearance using a Novel Nitric Oxide Nasal Spray NONS Treatment , The Lancet Regional Health Southeast Asia 2022;00 : 100036 . www.thelancet.com Vol 00 Month , 2022 . Available online 29 June 2022 , 100036 Recent publications : . Evaluation of Safety and Efficacy of Favipiravir in Adult Indian Patients With Mild to Moderate COVID 19 in a Real World Setting , International Journal of General Medicine 2022:15 4551 4563 . https : www.dovepress.com articles.php article i d 74993 . Efficacy and safety of single inhaler triple therapy of glycopyrronium , formoterol , and fluticasone in patients with chronic obstructive pulmonary disease : a double blind , randomised controlled trial , ERJ Open Research 2021 7 : 00255 2021 ; DOI : 10.1183 23120541.00255 2021 . http : openres.ersjournals.com lookup doi 10.1183 23120541.00255 2021 . Efficacy and Safety of Favipiravir , an Oral RNA Dependent RNA Polymerase Inhibitor , in Mild to Moderate COVID 19 : A Randomized , Comparative , Open Label , Multicenter , Phase 3 Clinical Trial , Journal of Infectious Diseases , 16 November 2020 . https : doi.org 10.1016 j.ijid.2020.11.142 . Technologies :",
"Senior Scientist II , Head of Bioinformatics . . . Technologies :",
"Senior Researcher . My research focuses on building systems that expand access to information . My work is interdisciplinary , combining human computer interaction , applied machine learning , and accessibility . I take a data driven approach to problem solving , and invest in packaging and releasing my research so that target users can take advantage of the new technologies . Publications : CHI 2020 , 2021 ; CSCW 2020 ; FAccT 2021 ; ASSETS 2019 , 2020 , 2021 ; TACCESS 2021 . I am a Senior Researcher at Microsoft Research . My research interests combine Accessibility , Human Computer Interaction , and Machine Learning . In my research , I take data driven approaches to address accessibility problems , helping to make the world a more equitable place for people with disabilities . I have a rich skill set spanning data analysis , algorithm design and implementation , systems building , full stack web development , and user centered design . My diverse past research projects have spanned data visualization , computational biology , computer music , applied mathematics , and network protocols .. Technologies :",
"Principal Scientist . Lead and manage small molecule drug discovery efforts around idiopathic pulmonary fibrosis and regeneration . Build in house wet lab capabilities including purchasing equipment and hiring personnel . Set up molecular and cellular assays for compound screening and hit identification and optimization . Management of CRO outsourcing strategies to maximize project success , accelerate research and . meet timelines . Establish and negotiate scientific collaborations with KOLs . Scientific leadership and project management in early drug discovery programs . Development of cell based assays to characterize and assess potency of new therapeutics . Expert in molecular and cell biology in the fields of neuroscience , oncology and metabolism . Collaboration and leadership in interdisciplinary projects , management of direct reports . Innovative and analytical thinker , data driven scientist with attention to detail . Effective communicator across levels and disciplines with successful track record in academic and corporate collaborations , data publication , and conference presentations . Technologies :",small molecules;interaction
NSF Fellow . PhD student in Department of Applied Physics Amir Safavi Naeini Lab . Working on quantum nonlinear optical devices . . Applied Physics PhD student at Stanford conducting research on nanoscale and quantum photonics .. Technologies :,
"Director , Applied Bioinformatics . . . Technologies :",
"Director , Oligo Chemistry Team . The Oligo Chemistry Team mainly focus on the generation and optimization of therapeutic oligonucleotides . . Anders Dahl n studied Chemistry at Gothenburg University Sweden where he finalized his M.Sc . in 2000 , and his Ph.D. on organometallic synthetic chemistry in 2005 . Anders was recruited into the chemistry section of CVRM , AstraZeneca R D , in 2005 and was initially working in small molecule discovery before he joined the New Modalities Chemistry Team in 2013 . During this time , Anders has held roles as Senior Scientist , Associate Principal Scientist , New Modalities Chemist and Team Leader . Currently , Anders is leading the Oligo Chemistry Team at Discovery Sciences at AstraZeneca R D Gothenburg . . Technologies :",small molecules;nucleic acids;developing
"Research Scientist Bioinformatics . Genomics , Genome Assembly , Genomic Variation Study , Next Generation Sequencing Analysis , Genotyping by Sequencing , Genome Wide and Trait Marker Design . . Technologies :",
"Senior Scientist , Applied Bioinformatics . . . Technologies :",
Research Felllow . . . Technologies :,
"Research Fellow . My current research focuses on image processing in a multi disciplinary team , the topics include chemical structure analysis developmental dynamics of cells . Developed a pipeline for denoising of Cryo EM images , including data augmentation with patch similarity check and also U Net based model for denoising ; 3D reconstruction of cryo EM ET with MLP and Computer Graphics based model , Neural Radiance Field NeRF ; Object detection , and semantic instance segmentation of microscopic images to trace the time evolution of embryo cells . with both U Net and Mask R CNN based model and their variant with cutting edge residual blocks . . I am actively seeking a research scientist engineer job focusing on Computer Vision Machine Learning Data at Bay Area . My current research focuses on a broad range of Computer Vision topics , including denoising of Cryo EM images to enhance the identification of structural heterogeneity ; 3D reconstruction of cryo EM ET ; object detection , and semantic instance segmentation of microscopic images to trace the time evolution of embryo cells . The architectures and techniques are range from CNN Convolutional Neural Network , attention , and MLP Multi Layer Perceptron . Basic statistics classical Machine Learning is also used to elucidate features dynamics of Chemical Biological systems . Separately , for my research of Multi scale Physics , please see my experience at UCLA for details .. Technologies : CryoEM",
Associate Principal Scientist . . . Technologies :,
"Principal Scientist . . Biochemist with more than 15 years of experience in the biopharmaceutical industry on both early and late stage research . Strong skills in biochemistry , protein purification , crystallization , X ray crystallography and cryo EM . . Technologies : Xray;CryoEM",biologics;structure
"Associate Director Medicinal Chemistry . . An experienced medicinal chemist , with track record of success in lead identification and optimisation in oncology , infectious diseases and metabolic diseases . Particular expertise in protacs , fragment based research , HTS work up , including phenotypic screening and target validation . An influential and highly productive member and leader of many cross disciplinary teams . Known for being questioning , rigorous and solution focussed .. Technologies :",molecular glues;proteins;small molecules;interaction;screening
"Senior Associate Scientist , Computational Biology Machine Learning . . . Technologies :",
"Scientist I , Computational Biology . Developed bioinformatics tools and platforms for translational biology OmicsView for interactive Omics data analysis co authored paper in CSBJ . Research areas : RNA Biology Computational Biology Bioinformatics Cancer Genomics Proficient in NGS data analysis , pipeline design , machine learning and related programming skills . 7 years of Bash programming , Python , R Bioconductor Shiny , and C Solid biology background that transforms high dimensional data into biological insights . Collaborated with wet lab colleagues to perform interdisciplinary researches , focusing on third generation sequencing , cancer immunology , animal and insect genomics .. Technologies :",
"Senior Scientist . Lipoproteins are a highly speciated population of nanoparticles that exhibit remarkable functional diversity . Best recognized for their role in lipid transport , lipoproteins also modulate the immune response , glucose metabolism , hemostasis , and inflammation . Moreover , lipoprotein dysfunction has been documented in several disorders including cardiovascular disease , sepsis , type 2 diabetes , obesity , and Alzheimer s Disease AD underscoring their central role in human metabolism . Lipoproteins achieve their pleiotropic effects through deployment of distinct subspecies , each with a unique complement of proteins that decorate the particle surface and act cooperatively to govern particle function . Indeed , the functional diversity of lipoproteins are mirrored by their compositional diversity as these particles can associate with 250 different proteins and lipids in human plasma alone . Our research is aimed at speciating lipoproteins and performing deep compositional , structural , and functional studies to unravel their role in human metabolic pathways . To this end we developed a profiling technology that can detect lipoproteins subspecies in biofluids such as cerebrospinal fluid , where they occur at extremely low abundance , with unprecedented sensitivity . Additionally , we established cryo EM protocols for resolving the molecular features of lipid bound apolipoproteins with high resolution . With access to over 30 premier mass spectrometers customized for performing deep proteomic and lipidomic analyses and a Titan Krios Cryo EM our mission is to i isolate unique lipoprotein subspecies from biofluids for deep compositional profiling , ii determine the structural organization of apolipoproteins on the lipid surface , iii reveal how the conformation of these apolipoprotein scaffolds modulate their interaction with important cofactors and cell surface receptors and iv understand how these compositional and structural features of lipoproteins govern their biological function . . Experienced research scientist with an excellent track record of production in apolipoprotein structure and proteomics research . Skilled in mass spectrometry , surface plasmon resonance , cryo electron microscopy , protein expression and purification , chromatography including immunoaffinity , size exclusion , anion exchange , and reverse phase , isotopic labeling , fluorescent labeling , cross linking , protein modeling , and bioinformatics . Creative and enthusiastic team player that interacts well with multiple personality types . . Technologies : CryoEM;SPR",membrane proteins;proteins;interaction;structure
"Postdoc . Biochemical research on Ebola and Marburg viruses . Scientific research on structural aspects of the replication , transcription and immune response evasion in filoviruses Ebola and Marburg viruses , SARS related coronaviruses and other highly pathogenic RNA viruses . OSINT analysis on biological threats related to highly pathogenic RNA viruses . Structural characterization of viral proteins and virus macromolecular complexes by means of transmission electron microscopy cryo EM and negative stain and X ray crystallography . Biophysical characterization of recombinant viral proteins expressed in and purified from heterologous systems . In vitro biochemical assays for the characterization of protein : protein and RNA : protein interactions . Analysis and consulting on topics related to the emergence of highly pathogenic RNA viruses as global health threats , as well as on biological warfare , bioterrorism , biodefense and counterproliferation of bioweapons that involve dual use technologies on highly pathogenic RNA viruses . . Technologies : Xray;CryoEM",nucleic acids;proteins;characterization;interaction;structure
"Senior Scientist . . Senior scientist with an interdisciplinary background within bionanosciences and experience in protein chemistry , development of immunological assays and biosensing . My scientific skills span from protein expression and purification , chromatography , antibody work , fluorescence and microscopy to the immobilisation of proteins on biosensor surfaces and handling of nanoparticles . Those skills are completed with experience of teaching and project management in cross functional groups . I am currently project lead of an international team developing immunoassays . Main skills : Immunochemistry , protein chemistry , development of bioassays , diagnostics devices , biosensing , project management , risk management , teamwork , scientific communication , lean oriented . Technologies :",antibodies;developing;expression
"Precision Medicine Researcher . . Precision medicine researcher with a background in proteomics and biochemistry . Enthusiastic and motivated professional with over 12 years of experience in structural biology and protein science covering assay development , Next generation sequencing NGS , cloning , upstream downstream processing , recombinant protein production , using high multiplex technique to identify actionable biomarkers and protein structure determination using X ray crystallography . Expert knowledge in handling drug discovery projects and project coordination . International work experience from India , Finland , Switzerland , and Sweden .. Technologies : Xray",proteins;structure
"Research Fellow . Analysing single cell RNA sequencing data to investigate Diabetic retinopathy . . I work on in bioinformatics for next generation sequencing , mainly on Illumina HiSeq MiSeq data , and 10x genomics single cell RNAseq , and previously used Roche 454 . I am interested in using sequencing data to identify underlying genetic causes of chronic disease and for regenerative medicine . I 'm convinced that sequencing and bioinformatics will make an increasingly big impact in medicine as sequencing costs reduce and accuracy and speed improve . I am also interested in database software , especially for medical applications . Specialties : Computer programming , medicine , next generation sequencing , bioinformatics .. Technologies :",
"Associate Scientist . . Have a great desire to learn , want to continuously improve , and find the process of learning exciting . . Technologies :",
Senior Bioinformatics Scientist . . . Technologies :,
"Principal Scientist . . HIGHLIGHTS Extensive experience in industrial drug development in CMC , cGMP manufacturing , regulatory , IND filing for biotherapeutic products . Extensive hands on experience in formulation of liposomal and polymeric nanoparticles of encapsulation of small molecule , oligonucleotide , and mRNA therapeutics ; familiar with Cell membrane isolation and cell membrane based nanosponge development and manufacturing process ; familiar with icellis and STR bioreactors Principle strengths include taking initiative to design and implement strategic plans through QbD approach and TPP setting ; effective communication skills to influence decision making , proven ability to deliver results with limited resources and accelerated timelines Management Cross function team communication and strong ability to work with teams to successfully drive results . Communicate statuses and implications to the executive management team , set technical directions relevant to business and promote advances in the state of the art related to applications and materials . Set process development goals and timeline ; allocate resources operators and instrumentations to ensure project execution . Foresee potential technical challenges , evaluate risk , provide strategic plans , support with technical leadership . Excellent organizational , documentation , and communication skills ; excellent ability to manage and work well in a team with adaptive learning and critical thinking Technical Nanoparticle Formulation and Process Development . In particular : Cell culturing using bioreactor ; Cell membrane isolation and purification ; Nanosponge formulation ; LNP formulation for siRNA , plasmid , mRNA and PNA transfection for gene therapy ; process development for scale up manufacturing from Lab to pilot scale in GLP GMP environment . Analytical characterization techniques . HPLC UPLC , UV vis Spectrometer , Electrophoresis , SPR , IR , CD , DLS , FTIR , RAMAN , Nanosizer DLS , Western Blotting ; Proficient with design , implement , management and data analysis of different projects . CMC , GLP GMP Documentation . Including SOPs , Investigational reports , Specifications , Equipment IOQ , Process validation , Aseptic process , Batch record and cooperate with QC and QA for the GMP activities . Structural Biology , cryo EM 3D reconstruction techniques ; solved high resolution maps of virus particles with or without antibodies and receptors using DED data set ; interpreted epitopes on the capsid to benefit the development of anti infective medicine vaccine . Technologies : CryoEM;SLS DLS;SPR",carriers;characterization;formulation
"Researcher . . 15 years research experience in academia as bioinformatician , modeller Computational Biology and project coordinator , specialising in human and different specious genomics and transcriptomics biomarker development for human disease research and systems biology behavioural modelling , pathway modelling and gene regulatory network . I was working closely with experimental biologists and clinicians in building realistic and useful models of biological phenomena from the molecular level , to the cellular , tissue , organismal and social levels also have Worked on Next Generation Sequencing data analysis Data conversion , Quality checking , Data Pre processing , De novo sequence assembly , Reference mapping , Transcriptome assembly and downstream analysis constantly with dedication , passion , ambitiously with optimal utilization of Bioinformatics knowledge in the field of Next Generation Sequencing , which would serve to the organization to become a valuable asset . TECHNICAL EXPERTISE Transcriptomics : Microarray RNAseq gene expression analysis NGS : data conversion , quality checking , pre processing , de novo assembly , reference mapping , downstream analysis Biostatistics : Microarray normalisation , PCA , clustering , correlation , multiple test correction , abundance curves Stats Packages : pytourch , tensorflow , limma , affy , vegan , edgeR s among others Tools : Bowtie , Cufflinks , BitSeq Programming : R , Pyton , Java , C Scripting : L Python , Shell , HTML , XML Workflows : Taverna Modelling Frameworks : FLAME , COPASI Standards : MIAME , SGML , SBML , CellML Operating Systems : Unix Linux , Mac , Windows Database : MySQL , SQL Server . Technologies :",
"Computational Biologist . Translational and exploratory data analysis in bioinformatics and computational biology across multiple therapeutic areas such as oncology and gastrointestinal diseases Analyze various types of molecular profiling and phenotype data to support Takeda discovery and development projects . . More than sixteen years research experience in computational biology bioinformatics With fourteen years research experience in the analysis of genomic and genetic big data for biomarker identification , target identification , patient stratification , disease subtype identification and clinical outcome prediction . More than seven years drug R D experience in big and small pharmaceutical companies With eighteen years experience in algorithm development for computational biology , bioinformatics and chemoinformatics Proficiency in C C , R , MATLAB , Python , Perl , Java , SQL , Oracle database , Linux Windows programming , HPC programming . Technologies :",
"Research Staff Member . . I am a researcher at Stanford University , specializing in biophysics and structural biology techniques . I currently work in the lab of Prof. Wah Chiu , a pioneer in cryo electron microscopy imaging and associated computational techniques . My research focuses on solving novel 3 dimensional structures of viruses and protein assemblies to better understand biological processes .. Technologies : CryoEM",proteins;structure
"Group Leader RNA Biology . . I am a biochemist group leader of the RNA Biology team at Evotec . I am overseeing operations of the RNA Biology unit , whith the Focus on Small molecule targeting of RNA as the target Spezies . This comprises all organizational aspects of running a highly competitive unit in a fast growing fiel of research . I am acting as the global lead in matrixed teams concentrated on early drug discovery projects on RNA targets . With an innovative mind and a clear vision , we create novel platforms for drug discovery efforts , enabling new Biology . In our external collaborations , I am also lucky to interact with amazing clients from start up to big pharma . And hence could participate in projects with a wide variety , from hit finding to clinical candidate . My expertise of 40 screening campaigns projects as a scientist project leader covers a whole range of tasks and responsibilities : Preliminary and continuous project research and evaluation Project planning , management , and documentation Regular project forecast and budgeting Providing primary contact and escalation path for customers Presentation Training for customers on department and management level Internal reporting and escalation on department and management level Supervision of staff Specialties : Biochemistry , NMR , RNA Biology , Molecular Biology , Structural Biology , RNA synthesis , RNA ligand interaction , Protein production , Fragment based drug design FBDD , Structure based drug design SBDD , High Throughput Screening , Viability assays , Riboswitches , microRNAs , Oncology , Antibiotics , CNS . Technologies : NMR",nucleic acids;small molecules;interaction;screening
"Bioinformatics Scientist . . I recently finished my PhD studies at JHU CS with a focus in Computational Genomics . I am interested in reducing reference bias in genomics both by developing pan genome indexes and writing tools to make it easier to run analyses on alternate references . During my penultimate summer at JHU I worked as an intern at Illumina , where I developed a tool to curate a database of structural variants derived from PacBio HiFi data . This tool is being used to quality control the database used by short read tools such as Paragraph to accurately genotype structural variants .. Technologies :",
"Research Associate II . Execute nucleic acid based protocols with DNA oligos Plan , conduct , and troubleshoot laboratory experiments Write experimental protocols , analyze results , and present findings Surface Chemistry and Material Science team . Research scientist looking to utilize data science skills in the field of biology environmental science . My experience includes topics in ecology , computer programming , and biotechnology . In graduate school at UC San Diego , I was researching life history and decision making strategies , conducting laboratory research on nematodes , and developing an extensive model in Python to simulate the life cycles and interactions of a worm population . Following graduation , I began building upon my data science journey through the organization , Metis , and completed half a dozen projects on various topics including machine learning , linear regression , and data engineering . During that time , I also started working at Illumina where I currently conduct research with oligonucleotides in the research and technology development department . I m looking to pursue a career that combines my technical skills in both biological and computational disciplines . Skills : Biology , Calculus , Python , R , Git GitHub , SQL , Tableau , Machine Learning , Microsoft Excel , Organization . Technologies :",
Graduate Research Assistant II . . Currently working under Dr. Bazil 's mentorship elucidating the pathological changes to mitochondria ultrastructure and calcium buffering under pathophysiological conditions associated with cardiovascular disease . My project combines mitochondrial bioenergetic studies with cryo electron microscopy to image and quantify changes in mitochondrial ultrastructure and link structure with function . This integrated study will reveal fundamental concepts in mitochondrial energy metabolism and identify strategies to improve the clinical outcome of individuals with mitochondrial diseases or dysfunction associated with calcium overload .. Technologies : CryoEM,
"Researcher . . An allround hands on scientist within immunology and cell biology with more than 20 years of lab experience . . In 2012 I accepted the challenge to work at Bionovion , a start up company in immune oncology . It has been great to see and help the company grow to its aqcuisition by Aduro Biotech in 2015 . My main focus is the B select Antibody Platform that involves generating highly specific and unique monoclonal antibodies with effective selection and expansion procedures , immortalization methods and partially automated HTS screenings assays . . At Organon NV which was acquired by Schering Plough and subsequently MSD I was coordinator of the Monoclonal Antibody platform were we generated and selected the PD1 antibody that was later developed as Pembrolizumab Keytruda . I ve been working as supervisor line manager on various immunological and assay development projects within MSD as well as in collaboration in TIPharma projects . . Specialties : Immunology , cell culture , assay development . Generating monoclonal antibodies . . Technologies :",antibodies;developing;screening
"XDF Research Fellow . I work on cross disciplinary projects in quantitative biomedical research on protein mutations , protein protein interactions , etc . at the MRC Institute of Genetics and Cancer . . I am a researcher in computer science , with a diverse background in mathematics , biology , chemistry , physics and psychology . Before jumping into research , I had experiences as a software developer in the industry and as a mathematics teacher in secondary education . I am now avidly interested in interdisciplinary research in the fields of biomedical computing , structural bioinformatics and computational structural biology . In the past decade , my research has focused on the computational modeling , simulation and analysis of complex physical systems , both in robotics and structural biology . At the algorithmic level , simulating mobile or flexible systems such as robots and molecules requires exploring a high dimensional space : the space of all the possible states of the system . My work has involved developing efficient algorithms and heuristics to address this challenge . I have published 24 articles in peer reviewed international journals and 18 articles in peer reviewed international conferences or workshops . I have been involved in other activities important to research , such as writing grant proposals , assuming editorial or organizing roles for journals or conferences , and presenting my work at conferences . I also have a lot of experience in developing research software , both in Python and in C , and in working with high performance computers . During my career , I have worked in various environments and in different countries . I have always tried to learn as much as I could from these diverse experiences and leverage this knowledge into every new job . For example , my experience in secondary education proved very useful when I later taught undergraduate students . I still benefit from this teaching experience when I mentor and advise the younger generation of researchers , from undergraduate to graduate students . I deeply believe that my teaching and mentoring skills are essential to my work in science . Indeed , I now strive to start my own research team .. Technologies :",
"Head of Contract Research and Business Development . Enabling Precision Medicine through Advanced Protein Biomarkers . Head of Contract Research : . Responsible for : . all academic and industry customer projects . HORIZON2020 project : MCDS Therapy Biomarker Discovery . project planning , management , reporting and scientific data analysis . platform development to cover new post translational modifications . Further responsibilities : . Building and maintaining Customer Relations . Representing Sciomics at international Meetings , Trade Fairs and Conferences . Customer Project Acquisition . Project Planning and Management for Precision Medicine Projects . Market Research and Analysis . Developing Marketing and Market Entry Strategies . Product Development and Management . . Protein profiling plays an essential part in today s biomedical research , striving to improve patients quality of life by using molecular signatures for diagnosis and treatment guidance . . At Sciomics , we believe that our explorative proteomic and post translational modification profiling platform enables true progress in precision medicine . Therefore , our internal development pipeline of innovative biomarker signatures for precision medicine is based on this powerful platform . . In addition , we offer services based on our scioDiscover profiling platform and R D collaborations for the discovery and validation of novel biomarkers , for drug target screening , the characterization of disease models , and for the analysis of pathway activity as well as mode of action analyses . What sets us apart is our team of scientific experts that takes pride in custom tailoring every project and consulting clients throughout the project . Our full service ranges from discussing experimental designs to in depth data analysis and a comprehensive study report . Fast and cost efficient , Sciomics powerful high content , high throughput antibody array platform delivers reliable results that can be easily translated into validation or clinical assays , thereby generating value and opening new avenues for biomarker discovery as well as preclinical drug discovery development programs . . Technologies :",
"Director of Bioinformatics . . PhD Computational Biologist with 10 years of experience leading the development of computational and statistical tools for the analysis of biological data Bioinformatics : NGS , RNAseq , Biomarker Identification , Whole Genome Assembly , Sequence Analysis , High Throughput Screening , Proteomics , Metabolomics , Microarrays Machine Learning Statistics : Random Forests , Logistic Regression , Elastic Net , Support Vector Machines , Neural Networks , Clustering , Classification , Linear Models Languages : Python , R , Perl , C C , MatLAB , Linux . Technologies :",
Chief Scientific Officer . . . Technologies :,
Senior Computer Biologist . I am working in Human Evolution Group . . Technologies :,
"Research Scientist . Develop and optimise separation methodology for Hemoglobin mutants in Thalassemia patients by applying Capillary Electrophoresis . . PhD with broad background knowledge in molecular biology , biochemistry , biotechnology , enzyme characterizations , and structural biology . Looking for R D positions in Biotechnology , Biochemical and Pharmaceutic industry .. Technologies :",enzymes;characterization;structure
"Biochemist Structural Biologist . Senior scientist in structural biology . Advisor for biophysical and kinetic techniques . Early project development . . Together with Dagmar Klostermeier wrote textbook on Biophysical Chemistry , published Feb. 2018 . Managed academic group of 5 biochemists performing cloning , protein purification and crystallization using state of the art spectroscopic and kinetic techniques . In depth understanding of and practical experience with key biophysical techniques , including optical spectroscopy absorption , fluorescence , circular dichroism , NMR , isothermal titration calorimetry , surface plasmon resonance , steady state and pre steady state kinetics coupled enzyme assays and stopped flow , respectively . Contributed knowledge in protein folding thermodynamics to improve stability and enzymatic properties of several enzymes used in diagnostics by site specific mutagenesis . Programmed high throughput crystal structure determination pipeline , determined 1000 crystal structures in SBDD projects .. Technologies : ITC;SPR;CD;NMR",enzymes;proteins;small molecules;interaction;screening;stability;structure
"Computational Chemistry Research Scientist . Using ML AI and Computational Chemistry for small molecule drug discovery . I am very passionate about using Machine Learning to discover new drugs . To that end , during my PhD studies at University of Michigan , I worked on predicting the structure of biomolecules using Machine Learning approaches . The goal was to design tools that can be used in virtual screening during the drug discovery process . I did my undergraduate studies from Indian Institute of Technology IIT Kharagpur majoring in physical chemistry .. Technologies :",
"Assisterende leder , Teststed Ballerup . . Jeg er uddannet Cand . Scient i biologi med speciale i cellebiologi og fysiologi . Under mit speciale og bachelorprojekt har jeg arbejdet med amfifatiske helixer AH fra GPCRs og BAR proteiner i deres rolle under traficking og lipid interaktion . Desuden har jeg ogs studeret prim re cilier og hvorledes AH har egenskaber til at drive GPCRs til den basale del og op via IFT systemet . Nu s ger jeg nye udfordringer hvor jeg gerne vil bruge nogen af mine mange erfaringer og teknikker . En kandidat i cellebiologi og fysiologi har kompetencer til at : Sammenfatte eukaryote cellers funktion og den cellul re homeostase . Sammenligne de strategier , hvormed eukaryote celler interagerer og kommunikerer med det ekstracellul re milj til regulering af udvikling , genekspression , differentiering og fysiologisk aktivitet . Sammenk de cellul re processer og regulationsmekanismer , herunder integrere samspillet mellem celler i samme organ og celler i forskellige organer . Integrere cellul re og molekyl re mekanismer i celle celle interaktion og signaltransduktion med en overordnet forst else af funktion og udvikling af v v og organer . Relatere overordnet celle og organopbygning til en helhedsopfattelse af flercellede dyr , herunder mennesket . Sammenfatte organismens overordnede fysiologiske systemer , deres normale funktion , samt funktion under belastning og udvalgte sygdomme . Integrere viden til beskrivelse og analyse af vigtige fysiologiske og patofysiologiske sammenh nge hos mennesket . En kandidat i cellebiologi og fysiologi har f rdigheder i at : Opstille og udf re praktiske eksperimenter til testning af cellebiologiske og fysiologiske hypoteser Analysere , fortolke og kritisk vurdere eksperimentelle data fra cellebiologiske og fysiologiske fors g Anvende relevante beregningsmetoder p fysiologiske problemstillinger https : studier.ku.dk kandidat biologi undervisning og opbygning specialisering cellebiologi . Technologies :",
"Director of Research Data Utilization . . Data scientist specializing in the pharmaceutical industry . Diverse background in large interdisciplinary projects including visualization of shRNA knock down experiments to identify novel therapeutic targets for cancer , library design to improve the efficiency of compound screening , and analyzing chemogenomic datasets to discover novel chemical probes . PUBLICATION OVERVIEW : http : scholar.google.com citations user oYUWc7YAAAAJ hl en 23 Publications , h factor : 15 , Total citations : 15,823 Specialties : R , Shiny , Algorithm development , code optimization , data integration , sequence analysis , network visualization , statistical analysis , compound library design , structure activity relationship studies , Pipeline Pilot , SQL , Perl , C .. Technologies :",
Radiation Protection Manager . Radiation Protection Manager Institute of Medical Physics and Biophysics . . Technologies :,proteins;structure
Bioinformatician . . . Technologies :,
Scientist . . Scientist who enjoys working in the lab . My focus shifted from papillomavirus and polyomavirus cancer related research towards antibody cancer therapeutic research . . Technologies :,antibodies;developing
"Laboratory Scientist . Currently a laboratory scientist within the microsatellite MS department at Weatherbys Scientific . Responsibilities : 1 Parental verification of equine samples using MS DNA . This is achieved via : . The extraction of DNA from hair and blood samples for thoroughbred and non thoroughbred varieties of horse . Amplification of MS DNA markers via polymerase chain reaction PCR . Size separation of MS DNA via capillary electrophoresis and subsequent analysis using Gene mapper software . 2 To determine the presence absence of alleles responsible for hoof wall separation disease within Connemara ponies . This is achieved using a Real time polymerase chain reaction assay qPCR . . 3 Quantify DNA samples after whole genome amplification prior to sequencing on the Illumina assay . . A microbiology graduate from the school of natural sciences at the National University of Ireland , Galway . Primary academic interests centred around the molecular mechanisms employed by pathogens during infection and subsequent immunological responses , in conjunction with the application of bacterial cells for the purpose of recombinant protein production . Final year project was undertaken in the recombinant protein laboratory , Microbiology department , National University of Ireland , Galway . Title of final year project The Isolation and Expression of a Recombinant Antibody Fragment for Prostate Cancer Targeting . Academic supervision provided by Prof. Gerard Wall and laboratory supervision provided by Delphine Antoine . Proficiency in software such as Word , Excel and PowerPoint . A former class representative for final year Microbiology , 2018 2019 . Currently working as a laboratory scientist at Weatherbys Scientific , a global leader in animal genomic solutions . Weatherbys is a well established company in the agri biotechnology sector with a long history of animal breeding solutions . Primarily responsible for the application of microsatellite MS DNA in order to parentally verify thoroughbred and non thoroughbred equine samples . Experience working in both research and high throughput laboratories . A range of laboratory skills obtained during the research project and as a lab member of the Weatherbys team . A dedicated , hard working and adaptable individual who enjoys working as part of a team . An outgoing people person by nature who thrives at problem solving and goal completion . Strongest personal skill is to successfully work alongside colleagues in order to achieve a goal . An Ambitious , driven and confident individual with aspirations of succeeding in the scientific industry . . . Technologies :",
"Associate Principal Scientist . Leading early small molecule and oligonucleotide drug discovery projects , designing screening cascades , project plans and hit identification strategies . Provide expertise in GPCR pharmacology , targeted delivery of antisense oligonucleotides , in vitro profiling and mechanism of action studies within the Mechanistic Biology Profiling function . We support our Therapeutic Areas , primarily Cardiovascular , Renal and Metabolic Diseases CVRM and Respiratory Immunology R I with SAR profiling , species translation and mechanism of action studies . . Experienced scientist and leader in the pharmaceutical industry with focus on early drug discovery and mechanistic biology . Skilled in oligonucleotide and small molecule profiling in cellular and biochemical assays , mechanism of action studies , GPCR pharmacology , early drug discovery project leader and pharmaceutical research .. Technologies :",membrane proteins;nucleic acids;small molecules;developing;interaction
"Staff Scientist . . I received my Ph.D. degree from Oregon State University , advised by Dr. Stephen Ramsey . My research area was leveraging machine learning techniques to identify regulatory single nucleotide polymorphisms SNPs in the non coding human genome . Now I work as a staff scientist at the Su Lab of The Scripps Research Institute . My job includes development of http : myvariant.info and Biothings framework .. Technologies :",
"Senior Scientist . . Molecular biology Experience in constructs design , RNA DNA purification , PCR , cloning , mutagenesis , gel electrophoresis . Protein biochemistry Use of chromatographic techniques for protein purification IMAC , ion exchange , size exclusion , hydrophobic in several expression systems : E. coli , S. cerevisiae , HEK293 , HeLa . Hands on AKTA systems Start Pure . Experience on techniques for investigating protein : DNA interaction EMSA and testing protein activity nucleotide binding and hydrolysis . Structural biology : X ray crystallography . Protein and protein RNA complexes crystallisation . Troubleshooting for optimisation of conditions . Cryo preservation . Experience on data collection at synchrotron sources ESRF , SLS , Soleil , data processing , structure solving SAD , MAD , MR , model building , refinement and model validation . Structural biology : single particle cryo EM . Experience with grid preparation and optimisation . Expertise in data processing using cryoSPARC , Relion and Scipion suites . Model building , interpretation and validation . Experience in Phenix and Refmac tools for cryo EM . Biophysics . Experience on Dynamic Light Scattering DLS and SEC Multi Angle Laser Light Scattering MALLS . Very good knowledge of analytical ultracentrifugation AUC , Differential Scanning Fluorimetry DSF . Knowledge of Surface Plasmon Resonance SPR and Isothermal Titatrion Calorimetry ITC . Management skills . Supervision and mentoring of PhD students . Lab work management . Coordination of intra and inter department including international collaborations .. Technologies : Xray;CryoEM;ITC;SLS DLS;SPR;AUC;DSF",nucleic acids;proteins;characterization;interaction;structure
"Senior Scientist . Senior Scientist at the Pharmaceutical development and manufacturing sciences , analytical development department ; large molecule method development . Scientific integrator for one of Janssen Biologics commercial products . Experienced in a wide range of analytical methods validation , troubleshooting , transfer , lifecycle management , pharmacopoeial requirements , regulatory submissions , project management and general GMP requirements . . Specialties : . Analytical method validation . GMP . Pharmacopoeial requirements . Project management . Cell culturing . Cloning techniques . Protein expression purification activity determination . Membrane protein enzymology . Technologies :",biologics;membrane proteins;developing;expression;quality
Research Associate . . . Technologies :,
Research Associate I . . . Technologies :,
Senior Deep Learning Bioinformatics Scientist . . . Technologies :,
"Mechatronics Engineer . I am part of the diffraction instrumentation team . In charge of electrical electronics , pneumatics , and automation in the development of autonomous machines and tools for X ray crystalography , small angle scattering , and Cryo electron microscopy . Tech . support to our machines installed in some of the beamlines in the ESRF European Synchrotron Radiation Facility . . I am a mechatronic engineer in the diffraction instrumentation team at the EMBL France European Molecular Biology Laboratory in charge of electronics , pneumatics , and automation . We develop autonomous machines and tools for X ray crystalography , small angle X ray scattering , and Cryo electron microscopy for laboratories and scientists around the world .. Technologies : Xray;CryoEM",
"Director Chemical Biology . . Director Chemical Biology with focus on building Exscientia 's capabilities in phenotypic drug discovery and targeted protein degradation . Experienced across a broad range of target deconvolution and validation methods . Previously medicinal chemist and manager of chemistry teams . Experience in hit to lead , fragment based drug discovery and lead optimisation across a number of medicinal chemistry projects and target classes such as kinases and GPCRs .. Technologies :",molecular glues;small molecules;interaction
"Principal process development scientist . Development and optimization of drug substance processes for manufacture of strict anaerobe bacteria cultures live biotherapeutic product , primarily with focus on downstream processing to obtain the right product format and characteristics for drug product . . . Technologies :",proteins;expression
Scientist II . . My work focuses on computational design of proteins and exploring new directions to leverage Generate s technology .. Technologies :,
Bioinformatician . Delivery of computational biology research in collaboration with the Centre for Experimental Medicine Rheumatology EMR and the Centre for Translational Bioinformatics C4 TB . . PhD Student at QMUL working collaboratively between the Centre for Experimental Medicine and Rheumatology and the Centre for Translational Bioinformatics . Working on multi omic data integration to try and identify drivers of disease with the ultimate goal of moving towards personalised medicine .. Technologies :,
"Cryo EM engineer at NanoImaging Core Facility . . I m a protein scientist using X ray crystallography and cryo EM together with functional and biochemical tools to understand the mechanism of action of membrane fusion proteins . I am a driven , resourceful individual with a proactive attitude . I am always open to new opportunities to contribute to solve relevant research problems . My specific fields of interest are virology , protein biochemistry , structural biology and drug discovery . . Technologies : Xray;CryoEM",membrane proteins;proteins;structure
"Sr . Manager Principal Scientist , Drug Product Lead . . Technically competent professional experienced in pre formulation , formulation development , biopharmaceutical and preclinical evaluation of injectable simple and complex , ophthalmic and oral liquid solid dosage forms . 1 Expertise in understanding small and large molecule chemistry , degradation pathways , characterization and stabilization techniques 2 solubility enhancement of poorly soluble drugs NCEs by salt formation , ASDs , Co crystals , Co amorphous systems via Hot melt extrusion technology , spray drying , SEDDS SMEDDS , nanoparticles , 3 Improving the stability of protein peptide oligonucleotide therapeutics . 4 Process development and optimization Aseptic processing freezing thaw mixing filtration fill finish lyophilization or unit operations blending granulation drying compression coating for drug product development for preclinical clinical supplies 5 Preparation of PreIND meeting request and support IND and NDA submissions . 6 Design and formulation development , process development and process optimization of oral , parenteral IV IM SC and ophthalmic topical hydrogels intra ocular injection formulations and related alternate drug delivery systems such as liposomes , solid lipid nanoparticles , ASDs , SEDDS , polymeric nanoparticles , modified release oral dosage forms , suspensions , lyophilized products etc . 7 Design and develop robust , scalable formulations , manufacture prototype dosage forms , and conduct drug product process development and process optimization activities in house . 8 Demonstrate scientific creativity , initiative and contribution to the team goals . 9 Highly motivated , innovative , detail oriented and responsible researcher with strong written and interpersonal communication skills , equally efficient in collaborative environment as well as an individual .. Technologies :",biologics;nucleic acids;peptides;proteins;formulation;stability
"Postdoctoral Researcher . In my current research , I use biochemical , chemical and structural biology approaches to advance our understanding of how proteins are made and secreted in parasites that infect and cause disease in humans . Ultimately , this research aims to provide new chemical and structural leads for the future development of drugs for the treatment of parasitic diseases , such as leishmaniasis and malaria . I am an experienced researcher specialising in small molecule drug discovery , with significant expertise working at the biology chemistry interface biochemistry , cell biology , synthetic organic and medicinal chemistry . In my postdoctoral work at the University of Helsinki , I develop small molecules as drug discovery leads and exploit their inhibitory properties to understand how proteins are made at the endoplasmic reticulum .. Technologies :",proteins;small molecules;structure
"Director . . Neuro imaging scientist with longstanding experience in molecular imaging with positron emission tomography PET and single photon emission computed tomography SPECT . Nuclear Medicine physician with a PhD in Functional Radioisotopic Imaging . Primary research interest is to develop imaging markers for neurodegenerative disorders in order to facilitate early diagnosis , patient stratification , to evaluate disease progression and to support design and execution of clinical trials . Research areas : protein aggregation , neurodegeneration and neuroinflammation . Skills : Translational molecular imaging , radioligand development , neuroreceptor mapping , PET quantification , research design , lecturing , good clinical practice GCP serving as PI for several clinical PET studies , scientific writing .. Technologies :",idps
"Director , Software Engineering and Bioinformatics . . Email : chris.edlund at gmail.com Google Scholar : https : scholar.google.com citations user nh9YN8YAAAAJ hl en . Technologies :",
"Principal Scientist . . Strong scientific background and expertise across Therapeutic Areas and ability to influence multiple stakeholders Managed and developed data driven strategies that facilitate selection of lead candidates and help define clinical strategies in Cardiovascular , Oncology and IO programs . Innovative Biochemist and Biophysicist with proven ability of managing , designing and implementing multiple projects efficiently and successfully Strategize , design , develop and execute biochemical and cellular assays for High throughput screening of multi million compound libraries and assess hits . Characterize protein protein , drug protein , drug nucleic acid , antibody antigen , and other molecular interactions via various biochemical and biophysical methods . Technologies :",antibodies;nucleic acids;proteins;small molecules;interaction;screening
"Senior Scientist . Lead Generation and Lead Optimization for various biological targets including Kinases , GPCR , Ion Channels and Enzymes ; Solid phase and parallel Solution phase synthesis of small focused libraries of small molecules for Lead Generation and Lead Optimization . Optimization of the potency , selectivity , in vitro ADME , in vivo pharmacokinetics and in vivo pharmacodynamics of the lead compounds in several different projects for anti cancer , anti inflammatory , diabetes and obesity therapeutics ; use of Structure Based Drug Design including information from X ray Crystallography and Molecular Modeling for Lead Generation and Lead Optimization . . Senior Medicinal Chemist with expertise in Synthetic Organic , Medicinal and Combinatorial Chemistry . Eighteen years experience in small molecule drug discovery research in the pharmaceutical and biotechnology industry . A proven track record of accomplishments in the design , synthesis and optimization of novel compounds for a variety of biological targets including Kinases , GPCR , Enzymes and Ion Channels . A history of creativity and productivity in research as demonstrated by a strong record of patents and publications . Solid experience in Structure Based Drug Design , Lead Generation and Lead Optimization . Excellent project leadership , supervisory and communication skills . Initiated projects and delivered proof of concept . Participated in external scientific collaborations and outsourced projects to contract facilities . Managed group research activities as part of a matrix team .. Technologies : Xray",small molecules;developing
". . My career is mostly concerned with proteins , their structure and function . Beginning with the isolation of rare membrane proteins from native tissue , I moved to overexpression of mammalian and human membrane and soluble proteins in E.coli and yeast . After purification the proteins were analysed for function by ligand binding and transport assays and subjected to 2D and 3D protein crystallisation and single particle electron microscopy for structural determination .. Technologies :",membrane proteins;proteins;interaction;structure
"Director , Structural Bioinformatics Laboratory . . Scientific and Technical Leader with a 13 year track record in Computational Chemistry , Structure based Drug Design , and Scientific Software Development . Progressive expertise from hands on Drug Discovery project support , scientific methods development , building and leading a world class Computational Chemistry department , to the development and deployment of enterprise level scientific software platforms . Extensive experience in conceiving and implementing leading edge computational strategies to accelerate Drug Discovery , in building high performing teams , and in hands on problem solving . Specialties : Structure based Drug Design , Scientific Computing , Computational Chemistry , Structural Biology , Protein Structure and Function , Machine Learning , Scientific Software Development , in silico ADMET , Combinatorial Chemistry . Technologies :",
"Senior Manager , Bioinformatics . . Research biologist with experience in laboratory and computational analytic settings . Also interested in science education and communication . Specialties : computational biology , population genetics , genomics . Technologies :",
Principal Scientist . . . Technologies :,
"Senior Scientist . Team lead and Project lead in Biotherapeutics Discovery : Broader understanding of Antibody Discovery and Development from antibody generation , v gene recovery and cloning , expression and purification , library screening , epitope binning , antibody engineering , optimization formatting , biophysical characterization to lead selection . Use high throughput SPR Biacore 8k , Carterra LSA to explore the full kinetic and assess the epitope diversity of antibody libraries , informing decision making in the drug discovery process . . Highly skillful professional focus on structure based drug discovery Ph . D in biochemistry with excellent training in structural biology ; 10 years of industrial and academic experience in the development of antibody therapeutics and small molecule inhibitors in the fields of oncology , immunology , inflammation and vascular disease . A strong track record of 2 granted US PCT patents , 2 US patent applications and 14 journal publications ; recipient of a 2 M NIH R01 funding in support of the development of an therapeutic antibody .. Technologies : SPR",antibodies;biologics;proteins;interaction;screening
"Research Associate III Computational Active Matter Mechanics . Computational biology Cancer biophysics Machine learning Systems Bio . Research Projects 1 . NLP and Machine Learning for Carcinogen Identification and Classifiction Co wrote novel algorithm for detection of carcinogens through NLP . Created dynamic programming algorithm for natural language processing clustering by contextual similarity trained on world wide scientific vocabulary . Aggregate knowledge of experimentally true carcinogens up until this day was previously done by manual curation . 2 . NLP and Machine Learning for Health Disparities Research Topics Network Determinations Created dynamic programming algorithm for natural language processing clustering by contextual similarity trained on world wide scientific vocabulary . Implementation of TFIDF algorithm which looks at overall frequency of word in abstracts ; removes common English words ; Graph of research key discoveries connect previously unlinked subject matter . 3 . Analysis of genetic diversity in clinical Mycobacterium tuberculosis strains Co wrote named novel algorithm , PseudoGenie , for detection of pseudogenes in a Pangenome : A presence absence approach based on missing annotation , alignment , pseudogene genomic features ; adapted from a similar less robust method in 2013 by Aurelion Carlier . https : gitlab.com LPCDRP pseudogenie Assembled pangenome with Roary . Followed up with extensive quality checks ; MCL CDHIT . Vetting annotation efficacy through a novel hybrid annotation approach using RATT PROKKA re trained specifically for M. tuberculosis genomes . Strain wise comparison of duplication events . Created dynamic programming script to reannotate clusters which had true duplication events by brute force categorization of gene s unique .gff i d to CDHIT information . Discovered overwhelming evidence of B Cell epitopes in the PE PGRS protein family of virulence factors . Discovered overwhelming evidence of recombination events occurring solely in the B Cell epitope , variable repeat region of PE PGRS genes . Created a dynamic programming algorithm ; reverse transcribing a protein s B Cell epitope coordinates aligns them to predicted DNA recombination location ; piecewise , using the 3 reference sequences needed to confirm a recombination event : Parent sequence donor ; Parent sequence acceptor ; resulting Recombinant . Exploration of trends in codon context derived from an analysis of 97 finished genomes of Euro American , East Asian , East African Indian , and Indo Oceanic clinical isolates . . Technologies :",
"Postdoctoral Scientist . Continuing working with Dr. John Briggs , under the Briggs Department Cell and Virus Structure . . Structural Characterization of enveloped viruses . Characterized a number of viruses , including SARS CoV 2 , HIV 1 , Ebola virus , Measles virus , and Respiratory Syncytial Virus . Proficient at cryo EM , cryo ET , and subtomogram averaging . Good at cryo FIB SEM , and cryo correlative microscopy .. Technologies : CryoEM",proteins;structure
"Scientific Director . . 20 years of leading biotechnology science followed 10 years of execution of protein optimization protein engineering in both academic and industrial settings . Co authorship of more than 50 peer reviewed papers and holds more than 300 issued patents within industrial enzymes and methods for protein engineering and directed evolution . H index 40 , citations 6000 . For a list , see e.g. https : scholar.google.com scholar start 30 q torben v. borchert hl da as sdt 0,5 My professional experiences and interests are within the following areas : Leading global research teams to excel in product Innovation in the industrial biotechnology space . For science driven companies it is important to tab into global innovation capabilities . After establishing and working with research teams in Denmark , India , China and North America it has become clear that it starts with culture and communication . Success depends on merging a global company culture with the local cultures . Excellent collaboration across geographies is based on a mutual understanding and acceptance of differences as well as relying on a foundation of a basic set of shared values . Holistic responsibility for value generation . Bringing organizations and individuals to an understanding of how the various parts play together in generating overall value and there is a shared will to deselect the non value generating activities . Driving Digitalization in the Science Space . Getting systems in place to capture data meta data automatically at the source is just the foundation to be followed by building acquiring the necessary competences in data handling and advanced analytics . The real value generation is not to be observed before the organization has adopted the essential data culture and mentality towards processes where the needs of future decisions direct the experiment planning and execution . Sustainability : Industrial Biotechnology holds the key for disconnecting economic growth from depletion of non renewable resources . Nature serves as the inspiration for the power of evolution and biotechnology takes advantage of the evolutionary principles in a laboratory setting demonstrating almost unlimited possibilities for constant improvement of efficiency , yields and savings of carbon dioxide and energy from industrial processes . Technical Competences : industrial biotechnology , enzyme optimization , microbial discovery , protein engineering , directed evolution , industrial enzymes , . Technologies :",enzymes;proteins;developing;engineering
"Undergraduate Researcher at the Kuriyan Lab . The Kuriyan Lab focuses on structures and mechanisms involved in signal transduction pathways . As an undergraduate assistant , I am currently investigating Raf Kinase activation in the MAPK ERK signaling pathway by Ras GTPases , which could have applications related to oncogenesis , autoimmunity , or developmental disorders . . I am a junior at the University of California , Berkeley interested in biotechnology . In my early career , I strive to cultivate my interest in genetics and biochemical pathways through hands on laboratory research . I am currently working in John Kuriyan 's Lab at UC Berkeley to endogenously tag BRAF with GFP in human cells , with an end goal of purifying BRAF complexes for structural analysis by Cryo EM . After obtaining my bachelor s degree , I plan to work in biotechnology for a couple of years before applying to PhD programs in Biology or Biochemistry .. Technologies : CryoEM",proteins;structure
"Senior Research Scientist . Expert in membrane and soluble protein chemistry . Expert in the purification of proteins for PGE CRISPR . Biophysical charaterisation of peptides proteins membrane proteins . Over production and purification of membrane bound and soluble protein targets . Assay development . Native mass spectrometry , intact mass , peptide mapping . . Experienced Senior Researcher with a demonstrated history of working in the pharmaceuticals industry . Strong research professional skilled in Membrane Proteins , Life Sciences , and an expert on the production and purification and QC of CRISPR proteins and base editors . Extensive experience with LCMS , SEC MALS and other characterisation methods .. Technologies :",membrane proteins;characterization;expression
"Senior Scientist . Food microbiology , fermentation , challenge studies , lactic acid bacteria , antimicrobial screening , project management product development . Competencies : Application Culture work pathogenic or spoilage causing bacteria , yeast and mould Antimicrobial compounds e.g. fermentates , essential oil , fatty acid derivatives , biopolymers Food microbiology Microscopic techniques e.g. AFM , CLSM , LM Molecular biology Bioinformatics next generation sequencing sample preparation and analysis QIIME , Cytoscape High through put compund screening using an automated robotic platform Project management Flow cytometry Biophysical work with phospholipids as vesicles and supported bilayer membrane . Technologies :",small molecules;interaction;screening
"Principal Scientist , Computational Chemistry . . As a computational biophysicist , my passion lies in identifying drug targets , biomarkers , and drugs to combat life threatening human diseases by unifying the power of novel computational techniques with information rich data sets obtained through various experimental approaches . My core competencies include : Technical Skills : protein modeling design , molecular dynamics simulations NAMD , GROMACS , CHARMM , AMBER , protein docking ClusPro , ZDock , structure and ligand based drug discovery Schr dinger , MOE , GOLD , Autodock , chemo informatics tools , Chemdraw , Babel , data driven modeling , Virtual drug screening , Molecular Visualization Pymol , Vmd , Chimera , Homology Modeling I Tasser , Modeller , Protein Sequence Analyses Clustal Omega , Blast , Mathematica , Workload management platforms Slurm , Lsf , Unix , Programming languages C , C , CSH BASH , TCL , HTML , GREP , AWK , Perl , Python , SQL , FORTRAN , Matlab Soft Skills : rapid learning , creative problem solving , excellent written oral communication skills , working with multidisciplinary team , project and time management . Technologies :",
"Senior Scientist Computational Biology . Contributing to drug discovery projects across the cycle : target identification and validation ; mode of action studies in vitro in vivo ; biomarkers ; tox aspects . Making biological sense of high dimensional , multi layered omics data across the drug discovery pipeline in close interaction with scientists and disease experts in the therapeutic areas . Computational biology expert support for drug discovery projects , mainly in the oncology therapeutic area both hematological cancers and solid tumors . Technologies : transcriptome , genome , epigenome . Applications : target identification and verification , disease and model characterization , assay development , therapeutic entity mode of action , response predictor biomarkers . Technology development of different omics layers and their integration , interpretation and visualization . . 15 years of experience in biological data analysis and applied computational biology bioinformatics of which 10 years in biotech pharma . Passion for mentoring people . Supporting the entire drug discovery pipeline : target discovery , disease characterization , mode of action , preclinical models , biomarkers , research data generated on clinical trial samples . Expertise in molecular mechanisms in different disease areas : oncology solid tumors and leukaemia ; inflammatory disorders RA , IBD , AD , PsoA , SLE , fibrosis mainly IPF . Biomarker discovery with high validation success , e. g. discovery of the methylation markers included in the Qiagen QIAsure Methylation Test Kit for cervical cancer . Technologies :",
"Senior Bioinformatics Scientist . . I graduated from UC San Diego with a Ph.D. in Bioinformatics in 2009 . Since 2014 , I am employed as a Bioinformatics Scientist at Invivoscribe Technologies , working on bioinformatics solutions to personalized diagnostic medicine . These include , but are not limited to , end to end analysis pipelines for data generated from NGS platforms from Illumina and Life Technologies . From 2009 to 2014 , I was a post doc in Dr. Gene Yeo 's lab at UCSD , in the Sanford Consortium for Regenerative Medicine , and my main focus was analyzing NGS datasets within the scope of the neurodegenerative disease ALS . In 2011 and 2012 , I published two first author papers , in collaboration with Dr. Don Cleveland 's lab , detailing the roles of the ALS related proteins TDP 43 and FUS TLS , and how their RNA binding functions may contribute to the disease . My work specifically centered on the analysis of CLIP seq , RNA seq , and splicing sensitive microarrays , and how the information gained from these experiments could be combined into a more cohesive explanation than any single experiment could provide on its own . I am currently working in collaboration with Dr. John Ravits to analyze more NGS datasets generated from human tissue of ALS patients , as well as working on a protein related to FUS TLS , TAF15 . My graduate career was spent in Dr. Geoff Rosenfeld 's lab , where I provided the bioinformatics support for almost 50 people . In this environment , I learned the value of communicating between such disparate fields as biology and computer science , and I feel well prepared to participate in any type of complex team projects . My research focus in Dr. Rosenfeld 's lab revolved around the analysis of ChIP on chip , ChIP DASL , and ChIP seq data , all related methods for discovering DNA binding protein binding sites in the targeted genome .. Technologies :",
"Electron Microscopy Specialist . Electron microscopes : JEOL 1210 , FEI Morgagni , Tecnai G2 20 and Tecnai TF30 helium . Scanning electron microscope Hitachi TM 1000 . Preparation methods : Cryo electron microscopy , Tomography , cryosectioning , vitrification of cryo em samples , high pressure freezing , freeze substitution , repair of electron microscopes Tecnai alliance training , freeze fracturing , freeze drying , critical point drying , sputtering of different metals , rotary shadowing , Negativ staining . . Technologies : CryoEM",structure
"Senior Scientist . . PhD in biotechnology and docent in biophysics with a broad background , ranging from molecular biology , to structural biology , to protein engineering , to molecular biophysics . Many years of experience in cutting edge research , leadership , management , and scientific communication .. Technologies :",proteins;characterization;engineering;structure
"Post doctoral researcher at Centre de Biochimie Structurale de Montpellier Montpellier , France . . I have more than three years of experience as a postdoctoral researcher . currently , I am Working as a Post doctoral Researcher at CBS . I have been awarded post graduate scholarship from Yeungnam University . I have been awarded research excellence award and international scientist awards . I am also Brand Ambassador of Bentham Science publishers since 2019 . My research interests mainly focused on nano virus proteins by using biophysical together with Cryo EM and cryo ET techniques .. Technologies : CryoEM",proteins;interaction;stability;structure
"Senior Scientist . . Researcher with over 10 years of experience in protein purification and quality control , structural characterization of enzymes and exploring protein protein interactions through biophysical methods . . Technologies : CryoEM",proteins;interaction;quality;structure
"AI Lead for Precision Medicine . . Machine Learning , Genomics , Bayesian inference . Technologies :",
"Research Associate . Project : Biophysical studies of the human DNA mismatch repair proteins Unraveling the sequential protein protein and protein DNA interactions that occurs after a mismatch is recognized on the DNA and that ends with the repair of the damaged strand . Use of high resolution single molecule techniques as prism TIRF and DNA Sky bridge to determine the interactions occurring during the downstream process after mismatch recognition . Project : Irreversible site specific fluorescent labeling of human DNA mismatch repair proteins for single molecule studies Finding a specific and irreversible way to fluorescent label the key protein of the DNA mismatch repair pathway by native chemical ligation of labeled purified peptides , chemical modifications of fluorescent dyes for specific labeling and fluorescent peptide protein labeling mediated by enzymatic reactions Project : Cryo EM Structural analysis of the main DNA mismatch repair proteins at high or near atomic resolution Using High resolution cryogenic Electron microscopy to decipher the tridimensional structure of these proteins . My scientific career has focused in the study of Lynch Syndrome or Hereditary Non Polyposis Colorectal Cancer LS HNPCC and subsequently the function of the DNA Mismatch Repair mechanism as causative of the disease , for more than 15 years . I am a multidisciplinary skilled and success driven professional with proven record of accomplishment in clinical assays , genetics , molecular and cellular biology , biochemistry , chromatography , mouse husbandry , data analysis and biophysics .. Technologies : CryoEM",proteins;characterization;interaction;structure
"Computational Biologist Research Scientist . . I am a research scientist at Berkeley Lab studying environmental microbiomes . In particular , I am working on a project to study the microbiome of the San Francisco Estuary and how these microbes impact element cycling in California . I have a special focus on improving metagenomics assembly and analysis methods , especially using long read technology by Nanopore and PacBio . For my research I am studying microbial community formation and and the underlying ecological and genetic mechanisms of how microbes interact with each other using bioinformatics and high throughput sequencing data . My goal is predictive biology one day we will be able to predict what microbes produce and how they interact with each other just from their DNA . For my graduate studies I worked on the discovery and function of small RNAs using a combination of computational and molecular biology techniques . I used high throughput sequencing technology and bioinformatics algorithms in my work . I grew extremophilic microbes that live at boiling temperatures and breathe sulfur compounds . Specialties : Metagenomics , amplicon sequencing , microbial genomics , RNA Bioinformatics , snoRNAs , comparative genomics , archaeal and extremophile biology . Technologies :",
"Staff Machine Learning Scientist . Accelerating the discovery of therapies for aging by targeting the biological processes of aging . . I am a Machine Learning Deep Learning researcher with interests in applications of computer vision in healthcare . I have a Ph.D. in Computer Science from Brandeis University with a specialization in applications of deep learning in vision and language and a Biomedical Engineering degree . I currently work at PathAI as a Research Lead . In the past , I have worked at Microsoft Research , Qualcomm Research , and Philips Research . More at https : iamaaditya.github.io about . Technologies :",
"Senior Bioinformatics Scientist . . Bioinformatics Scientist with 10 years experience in Next Generation Sequencing whole genome sequencing whole exome sequencing Metagenomics , metatranscriptomics RNA Seq , de novo assembly data analysis , specializing in platform , pipeline and software development in biotechnology industry and CAP CLIA certified laboratory . Expertise : NGS Library and sequencing QC NGS data analysis WGS , WES , RNAseq , Target Enrichment NGS , scRNAseq Bioinformatics tools HISAT2 , STAR , BWA , Bowite , Blast , HTseq , Salmon , RSEM , DEseq2 , Bioconductor , DeepTools , MEME , Homer , MACS2 , GATK , Picard , SAMtools , BEDTools Public database : dbSNP , KEGG , CLINVAR , HGMD , GEO , ENCODE , TCGA , Ensembl UCSC IGV Genome Browser Programming in Shell Script , R , Python , JAVA Platform : Linux Windows Mac OS , AWS , Github , Conda , Oracle VM VirtualBox , Docker Database : MySQL . Technologies :",
"Postdoctoral Research Scientist . Disease modelling by genome editing using CRISPR Cas9 . Cardiac phenotyping in cardiomyopathies relevant gene mutants . Next generation sequencing and transcriptome analysis . Molecular cloning and gene expression analysis . Drug and Target Discovery Researcher , seeking a challenging opportunity in Human Medicine Diagnostic and Genome Engineering . Deep domain knowledge in Diabetes and Cardiovascular field , Regeneration , Reprogramming cell fate , High throughput Biology , Genome Engineering and relevant hands on experience in Assay development , Process optimization , Cost reduction and Project management . Open for discussions and collaborations . Technologies :",
Researcher . Identified rare mutations in patients who are resilient to Alzheimer s disease through examination of whole genome sequencing with biocomputational tools 2020 ongoing . Isolated loci from genome wide association studies GWAS and fine mapped each locus to identify the likely causal variant of Alzheimer s disease 2019 2020 . . . Technologies :,
"Senior Scientist , Biochemistry . For more than a decade , next generation DNA sequencing has transformed every aspect of the life sciences . However , genetics is only one component of human disease . New tools are required to understand how genes interact with the environment to improve how we develop drugs , diagnose patients , and combat outbreaks . Our R D team plays a critical role in developing products that will be used all around the world . As Sr . Scientist , Biochemistry , I bring expertise in working with complex enzyme systems . I am responsible for the development , optimization , and troubleshooting of protein reagents at the core of our sequencing technology . Core responsibilities : Develop , optimize , and troubleshoot protein reagents at the core of a single molecule protein sequencing technology Purify and biochemically characterize novel proteins and enzymes Develop screening methods for proteolytic enzymes Characterize proteins and biological systems using biochemical , biophysical , and structural techniques . My strongest asset stems from combining solid science knowledge in membrane protein structural biology with compelling communication skills . My Ph.D. project allows me to investigate the structure function relationship of the human adenosine A2A receptor using SEC , EPR , and cryo EM . I am interested in jobs as a scientist or post doctoral researcher in structural biology membrane protein analytics in the biopharmaceutical industry , as I get to draw from my 4 years of research practice at the Ph.D. level as well as my keen interest in drug development . Besides , scientific communications are my strong suits given my substantial skills in interpersonal and organizational communication developed through my experiences in graduate school . I have given nearly 20 poster and oral presentations at seminars and conferences and have been significantly involved in the branding and marketing aspects of scientific symposia and events of campus wide , state wide , and national stature . I also have experience and education in teaching and mentoring at many levels from grade school to college students , which translates to my abilities to be a strong collaborator and good team player . Look forward to connecting with you .. Technologies : CryoEM",enzymes;characterization;developing;expression
"Research Fellow . . I address fundamental challenges associated with learning from multi label data and its applications . In addition , I am interested on designing machine learning algorithms to predicting various biological functions e.g. metabolic pathway from genomic sequence information .. Technologies :",
"Scientist . . I work at the intersection between metabolism , transcriptional regulation , computational biology and machine learning . My skill sets are within the areas of molecular biology and computer science so I integrate them to understand the deep underlying order within complex biological systems . On the one hand , I apply machine learning algorithms for pattern discovery in biological data , followed by experimental validation . On the other hand , I 'm interested in finding ways to emulate strategies from evolutionary adaptations in living systems to improve existing machine learning systems . Email : agudelo mit.edu Office : Ray and Maria Stata Center 32 Vassar St. , Cambridge MA . Technologies :",
"Protein Scientist . . I am a highly dedicated 29 years old young scientist looking for new challenges after a successful Industrial Ph.D. program in the biotech industry . I am imagining myself as a part of a biotech company where my strong background in protein chemistry can make an immediate impact on the growth of the company . My skills comprise the fields from molecular biology to biophysics ; from cultivation cells and protein expression in large scale 300L fermenters to downstream purification by various HPLC methods IMAC , gel filtration , Ion exchange , affinity chromatography on kta system and Unicorn software . Furthermore , I have worked extensively on functional and structural characterization such as LS , X ray , DSF , etc . of proteins and especially membrane proteins . I have previously been part of the development from idea to an established large scale production . Therefore , I am used to the challenging environment in a small fast growing company and I am very adaptable to sudden changes . On a daily basis , I have engaged with both technicians , HR personnel , project managers , and daily leaders . As a scientist , I am very detail oriented ; keen on finding the solution ; and motivated by solving problems . Due to my spare time hobby , playing football , I have also developed excellent team player skills .. Technologies : Xray;DSF",membrane proteins;expression;stability;structure
. . . Technologies : CryoEM,structure
"Intellectual Property Manager . . Exceptional life science researcher with expertise in a broad variety of complex techniques ranging Bioinformatics , Electrophysiology and Cryo electron microscopy . Strategy driven and analytical thinker with outstanding interpersonal skills . Committed team player and quick learner aiming to broaden his knowledge in economy and business .. Technologies : CryoEM",
"Associate Professor . My current research project focuses on delivery of therapeutic substances across the blood brain barrier with a special focus on halting or even reversing epileptogenesis . I am a research professional with a Doctor of Philosophy Ph.D. in Biochemistry from University og Stavanger . My publications demonstrated my skilles in Membrane Proteins , Cell Culture , Cell Based Assays , Western Blotting and Gel Electrophoresis technology . I have experience teaching protein biochemistry and molecular biology . I have since 2011 worked on elucidating the function of LIL3 , a protein identified in the late steps of chlorophyll synthesis . The last two years , I have characterized serum derived exosomes for use in therapeutics . . Technologies :",
"Senior Bioinformatics Software Developer . Launched and operates a software engineering service that helps labs accelerate their research by developing usable , robust , and maintainable scientific software . Promotes and implements software engineering best practices , such as automated testing , code reviews , continuous integration , and refactoring to enable sustainable and reproducible research . Led development of a federated COVID 19 data aggregation platform for Ivy Consortium using MongoDB Atlas , Node.js , and R Shiny . Led software design and implementation of an integrated cloud based genomic data analysis and visualization system for Harvard Stem Cell Commons using Python , Django , Celery , PostgreSQL , AngularJS , AWS SDK for JavaScript , and Terraform . Developed and maintained bcbio , a Python toolkit for automated high throughput sequencing analysis . . Software engineer with over 15 years of professional experience specializing in cloud based bioinformatics web application development and high throughput sequencing pipelines . Technologies :",
"Senior Scientist . . Experienced Scientist with a demonstrated history of working in the biotechnology industry . Skilled in Recombinant DNA technology , SDS PAGE , Molecular Biology , Java , and Teamwork . Strong research professional with a Master of Science MS focused in Bioinformatics from Johns Hopkins University Advanced Academic Programs . . Technologies :",
"Senior Scientist . . Senior Scientist in Computational Biology , focusing on scalable tool development for single cell genomics and spatial omics .. Technologies :",
Postdoctoral Statistician . . . Technologies :,
"Principal Scientist . . Innovative and analytical professional with substantial experience in research and development , biomedical science , software development , machine learning , and data analytics analysis . Outstanding researcher in the field of biomedical sciences with 14 peer reviewed publications with emphasis on bioinformatics and biomedical imaging analysis . Proven track record of designing , developing , and implementing innovative data driven ML AI solutions and designing optimization algorithms and predictive analytical models using relevant techniques and tools . Exceptional advanced data modeling and structuring , statistical evaluation , artificial intelligence , project management , machine learning , big data analytics , data visualization , and cloud computing skills . . Technologies :",
"Undergraduate Research Fellow , Buenrostro Lab . Developed novel computational techniques for bulk and single cell genomic and epigenomic data analysis Characterized pathways of transcription factor activity in the development of pulmonary adenocarcinoma Assisted in CRISPR Cas9 knockout screens to validate computational findings Tyler Jacks Lab , MIT Discovered prognostic biomarkers significantly associated with patient survival using DNA methylation data . As an undergrad at MIT specializing in Computational Biology , I 'm excited about the possibilities of computational and data science technologies in medical research . I look forward to applying my passion in this area to address new challenges with breakthrough potential .. Technologies :",
"Postdoctoral Scholar . . My research interests lie in protein protein interaction mechanisms . I am especially interested in protein protein interactions playing regulatory roles in cell signaling pathways which are mostly related to development , ocular , and degenerative auto immune diseases . The major challenges in understanding the interaction mechanism are their promiscuous but context dependent nature and the complex networking of signaling pathways . I am trying to elucidate the challenges by utilizing various structural biology techniques Crystallography , NMR , SAXS , and Cryo EM , thermodynamic assays , and computational tools Bioinformatics , Molecular dynamics . Once understanding the mechanisms , one can design targeted drugs derived from peptides and implement a therapeutic system to patients through systems biological approach .. Technologies : CryoEM;NMR",proteins;interaction;structure
"Research Fellow . Two year research program providing intensive research training to 5 6 undergraduates per year committed to graduate studies and careers in biomedical research Contributed to critical thinking and discussion of experimental design , presentation of data , and overall methodology in papers from a variety of disciplines through weekly journal clubs seminars with other i2URP scholars and UCLA faculty . I 'm currently a third year at UCLA , completing a double major in Computer Science and Computational and Systems Biology . I have experience in biology , chemistry , math , statistics , data science , and software engineering . I 'm deeply interested in single cell transcriptomics but have experience with proteomics and genomics as well . I have worked extensively with model organisms C. elegans , in particular but also have experience with human and medical data tumor transcriptomics . Feel free to reach out to me about anything . Technologies :",
"Lecturer in Computing Science . . To write algorithms that write machine learning algorithms . Specialties : Genetic Programming , Evolutionary Computation , Machine Learning . Hyperheuristics .. Technologies :",
"Director Global PK PD Pharmacometrics . . Expertise in PK PD , Pharmacometrics and quantitative clinical pharmacology popPKPD efficacy , PKPD , Exposure response , PBPK PD model development and simulation , Numerical Simulation , Statistical Analysis , Machine Learning , Time Series Analysis , Quantitative Medical Image Processing and Analysis , Computer Vision , Computational Fluid Dynamics CFD simulation .. Technologies :",
"Senior scientist Scientist II . Analytical development of biopharmaceuticals with a focus on gene therapy approaches such as using mRNA LNP and AAV . . Development of mRNA vaccines . Analytical methods development . CMC experience . . Enthusiastic and motivated Scientist specialised in gene therapy , cancer research and preclinical drug development , with experience in both academia and industry . . Experience : . research project management , development of innovative therapeutic strategies . biopharmaceuticals . CMC experience for mRNA therapeutics . GMP knowledge . drug discovery . staff and student supervision and mentoring . research collaborations : strong ability to work within a multidisciplinary team . proven communication skills by multiple presentations in local and international scientific meetings and also public engagement activities . scientific writing , including peer reviewed research review articles , book chapters , grant applications . Result oriented , a team player , always eager to embrace new challenges , quick learner , with strong communication skills and dedicated to the improvement of current therapies . . Interests : . Vaccines mRNA Gene therapy Cancer Cancer stem cells Cell therapy Tumour microenvironment miRNAs Drug delivery Nanoparticles Delivery systems Biomaterials Personalised medicine . . Technologies :",biologics;carriers;nucleic acids;characterization
"UKRI Innovation scholars secondment . The UKRI Innovation secondment is a new fellowship scheme , which is enabling me to work with Luiz Pedro Carvalho for the next three years on a chemogenomic project to study the metabolism of pathogenic Mycobacteria , which cause Tuberculosis , as well as a number of neglected diseases . The fellowship will allow me to apply my knowledge of small molecule drug discovery , while expanding my microbiology expertise . I will also have the opportunity to learn and apply genomics and metabolomics techniques . Eventually , I will be able to utilise my enzymology biochemistry skills . Throughout this project I will remain an employee of GSK will report to Andrew Powell in the Chemical Biology UK group , led by David House . . I am an innovative , creative and entrepreneurial Biochemist with over 19 years of drug discovery experience . Enthusiastic , conscientious and a hard working problem solver , I have a proven track record of success . Customer focused with a drive to deliver on commitments while continually seeking improvements where necessary . I have well developed communication , networking and presentation skills with the ability to build relationships and interact positively at all levels . I am an experienced , energetic programme leader , matrix team member , manager and supervisor , who seeks to motivate and engage others . . A post doctoral Biochemist with extensive scientific expertise in both academic and pharmaceutical research . In the first 13 years of my career , I was involved in pharmaceutical research at GlaxoSmithKline , where I developed my scientific capability and credibility in early drug discovery research with responsibilities in therapeutic program leadership and the management and development of employees , PhD students and industrial placement students . During the last 6 years of my career I have developed a strong background in enzymology , biophysics and protein biochemistry with the application to enzyme mechanism , assay development , small molecule screening and mode of action studies . I also have a strong working knowledge of cellular assays and their development , particularly with application to target engagement and intracellular kinetics , and a burgeoning understanding of microbiology . . . Technologies : Xray;CryoEM;FRET",proteins;small molecules;characterization;interaction
Scientist II . . . Technologies :,
"Postdoctoral Researcher . Research in Protein Biochemistry , Molecular Biology and Structural Biology , Cell Biology The Nuclear Pore Complex is nature s largest and most versatile transport channel . It is an approximately 120MDa complex or about 10 million atoms . It is also the sole gateways that facilitate the macromolecular exchange across the nuclear envelope with the help of soluble transport receptors . We carried out structure function studies of the cytoplasmic face of the NPC with the ultimate goal of understanding the role of NPC regulation the mRNA export . . I am a structural biologist and biochemist with 10 years of research experience . I possess expertise in protein expression , purification , analytical characterization , and structural analysis . Driven by my love for science and passion for mentoring , I strive to solve difficult challenges . My current work is one of the most challenging projects and involves solving structures belonginging to the Nuclear Pore Complex , the largest transport channel in eukaryotic cells . I successfully led state of the art research in a highly competitive academic environment from experimental design to data analysis . SKILL SET : Heterologous protein production in Microbial E. coli , insect cell sf9 and Hi5 , and Mammalian cells HEK293 . Hand on experience with AKAT start , prime , FPLC , Pure , and UNICORN software . Extensive working experience with protein purification : Affinity Ni NTA , GST , Protein A , IEX , HIC , SEC , and classical methods Ammonium sulfate precipitation , Sucrose gradient , etc . . Expert in protein crystallography including crystallization , structure determination , and analysis . Experience in single particle cryo EM workflow including grid freezing and screening , data collection and processing , three dimensional reconstruction and model building .. Technologies : Xray;CryoEM",proteins;characterization;expression;interaction;structure
"Principal Scientist II . Principal Scientist II in the Bioinformatics and Genotyping Group in Seeds Research at Syngenta . My primarily focus is on the development and deployment of functional genomics tools analyses . My role includes acting both as a project leader and an active team member in multiple , cross disciplinary project teams dedicated to delivering innovative traits in multiple crops . . I am a computational biologist with 20 years of experience , currently working on functional genomics applications in agricultural biotech . My present focus areas include data integration , Omics data analysis , variant effect prediction , and gene expression regulation . I am also interested in exploring new ways to utilize small RNAs and applications of machine learning models particularly in the domain of precision gene expression . Specialties : Experimental data analysis , including primary statistical data analysis and biological interpretation of results . Pathway and network analyses co expression networks , data overlay , pathway enrichment , gene expression analysis , multi Omics data analyses , promoter design . Design and implementation of knowledge management tools and technologies for data integration . Database and object oriented programming and design . Experienced in Java , R , R Shiny , Python , Perl , C , SQL , MongoDB , Windows , Unix , Oracle , BLAST , Cytoscape , BioXM , BioPAX , and RDF .. Technologies :",
"Team Leader Biochemist Drug Discovery Project Management . At present position , my research is focused on the screening of natural products against drug targetable receptors in diseases Triple negative breast cancer , prostate cancer , Alzheimer 's disease , and aging and infections viral and anti biotic resistant strains using both in silico and in vitro approaches . . ACHIEVEMENTS . . Executed virtually screening and molecular simulation of designed ligand libraries as MMPs inhibitors ; results in the identification and in vitro validation of 20 natural compounds . . Operated computational simulations on natural compounds as MMPs inhibitors that assisted in the procurement of a 200,000 USD grant from the Ministry of Education Korea on biocosmetics research in 6 months . . Demonstrated complex data analysis and scientific writing skills which results in two high quality scientific publications within 6 months ; and a total of 15 publications within 3 years . Strong leadership and team management skills via teaching , training , and supervision of 10 junior researchers in an interdisciplinary working team on molecular genetics data analysis , genetic engineering , sequence data analysis , drug discovery approaches , and oparticle development for drug delivery . . COMPETENCES . . Cell enzyme based assay . Protein chemistry . Western blotting . Nanoparticles and oemulsions . Scanning Transmission electron microscope . Fourier transform infrared spectroscopy . Raman Spectroscopy . X ray powder diffraction . Virtual screening and docking simulation . Molecular Mechanics and Quantum Mechanics Simulation . I am a scientific researcher and project manager with 9 years of experience in academia and industry ; and experience in teaching over 400 students at the university level . My specific expertise includes in silico and in vitro biological characterization of natural products , recombinant protein expression , enzyme and cell based assay development , sequence data analysis , and establishment of standard operating procedures SOPs . I enjoy working on a goal and result oriented projects in a fast paced and dynamic environment . . I would like to connect with experts working on distinct research subjects in industry and academia to grow my professional network . . Actively seeking opportunities as a scientist to capitalize on my expertise in protein chemistry and drug discovery against diseases and infections . Please feel free to connect me : . shivz . biotech gmail . com . TRANSFERABLE SKILLS . . Leadership . Analytical Thinker . Complex Problem Solving . Scientific Writing . Project management . Team Management . SCIENTIFIC EXPERTISE . . Cell and enzyme based assays development . Protein Chemistry : Recombinant protein expression and purification , Protein profiling , Protein protein interaction , Protein functionalization , Ribosome Display , Immunostaining , and Bioimaging . Drug Discovery : Structure based Drug discovery , Ligand based drug discovery , Reverse docking , Pharmacophore modeling , QSAR modeling , Protein modeling , Molecular docking , Molecular dynamics simulation , Protein peptide modeling , Quantum mechanics molecular mechanics calculations for small molecules DFT , NBO , FMO EDA , QM MD simulation . Biophysical techniques : HPLC , FRET , BRET , FTIR , XRD , XPS , TGA , DLS , SPR , SEM , TEM , AFM , Confocal Microscopy , Raman Spectroscopy , Bioluminescence spectroscopy , and Fluorescence spectroscopy . Computer Programing : MATLAB and R programming . . Technologies : Xray;SLS DLS;SPR;FRET",proteins;small molecules;expression;interaction;screening;structure
Scientist 1 . . . Technologies :,
Crystallization Facility Manager Scientific officer . Scientific and technical expertise : Run the crystallization facility Support users to get crystals and to optimize them Able to drive scientific projects occasionally in parallel of running a facility from protein expression to solve structure Cryo EM microscope operator Titan Krios and Talos Artica Protein complex structure resolution by Cryo EM Training of new users to operate Cryo EM microscopes Stocks management Equipments maintenance Presentation of progress report . Structural biologist with expertise in Crystallography and Cryo EM . Available from June 2023 negotiable . Technologies : CryoEM,proteins;expression;structure