Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In normal volunteers receiving indomethacin, the administration of diflunisal decreased the renal clearance and significantly increased the plasma levels of indomethacin.

Output: <diflunisal, mechanism, indomethacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In some patients, combined use of INDOCIN and diflunisal has been associated with fatal gastrointestinal hemorrhage.

Output: <INDOCIN, effect, diflunisal>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, diflunisal and INDOCIN should not be used concomitantly.

Output: <diflunisal, advise, INDOCIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a study in normal volunteers, it was found that chronic concurrent administration of 3.6 g of aspirin per day decreases indomethacin blood levels approximately 20%.

Output: <aspirin, mechanism, indomethacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant use of INDOCIN with other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy.

Output: <INDOCIN, advise, NSAIDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, when any additional drug, including INDOCIN, is added to the treatment of patients on anticoagulant therapy, the patients should be observed for alterations of the prothrombin time.

Output: <INDOCIN, advise, anticoagulant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In post-marketing experience, bleeding has been reported in patients on concomitant treatment with anticoagulants and INDOCIN.

Output: <anticoagulants, effect, INDOCIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be exercised when INDOCIN and anticoagulants are administered concomitantly.

Output: <INDOCIN, advise, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When INDOCIN is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased.

Output: <INDOCIN, mechanism, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be used if INDOCIN is administered simultaneously with methotrexate.

Output: <INDOCIN, advise, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: INDOCIN has been reported to decrease the tubular secretion of methotrexate and to potentiate its toxicity.

Output: <INDOCIN, mechanism, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin.

Output: <non-steroidal anti-inflammatory drugs, effect, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored.

Output: <NSAIDs, advise, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Capsules INDOCIN 50 mg t.i.d. produced a clinically relevant elevation of plasma lithium and reduction in renal lithium clearance in psychiatric patients and normal subjects with steady state plasma lithium concentrations.

Output: <INDOCIN, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: As a consequence, when INDOCIN and lithium are given concomitantly, the patient should be carefully observed for signs of lithium toxicity.

Output: <INDOCIN, advise, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: INDOCIN given concomitantly with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.

Output: <INDOCIN, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, when INDOCIN and digoxin are used concomitantly, serum digoxin levels should be closely monitored.

Output: <INDOCIN, advise, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In some patients, the administration of INDOCIN can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics.

Output: <INDOCIN, effect, loop diuretics>, <INDOCIN, effect, potassium-sparing diuretics>, <INDOCIN, effect, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It has been reported that the addition of triamterene to a maintenance schedule of INDOCIN resulted in reversible acute renal failure in two of four healthy volunteers.

Output: <triamterene, effect, INDOCIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: INDOCIN and triamterene should not be administered together.

Output: <INDOCIN, advise, triamterene>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The potential effects of INDOCIN and potassium-sparing diuretics on potassium kinetics and renal function should be considered when these agents are administered concurrently.

Output: <INDOCIN, effect, potassium-sparing diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Most of the above effects concerning diuretics have been attributed, at least in part, to mechanisms involving inhibition of prostaglandin synthesis by INDOCIN.

Output: <diuretics, effect, INDOCIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal antiinflammatory drugs including INDOCIN has been reported.

Output: <beta-adrenoceptor blocking agents, effect, non-steroidal antiinflammatory drugs>, <beta-adrenoceptor blocking agents, effect, INDOCIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: INDOCIN can reduce the antihypertensive effects of captopril and losartan.

Output: <INDOCIN, effect, captopril>, <INDOCIN, effect, losartan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with anastrozole (see CLINICAL PHARMACOLOGY   Drug Interactions and CLINICAL PHARMACOLOGY - Clinical Studies - Adjuvant Treatment of Breast Cancer in Postmenopausal Women subsections).

Output: <tamoxifen, advise, anastrozole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of anastrozole and tamoxifen resulted in a reduction of anastrozole plasma levels by 27% compared with those achieved with anastrozole alone.

Output: <anastrozole, mechanism, tamoxifen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Estrogen-containing therapies should not be used with ARIMIDEX as they may diminish its pharmacologic action.

Output: <Estrogen, advise, ARIMIDEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chlorthalidone may add to or potentiate the action of other antihypertensive drugs.

Output: <Chlorthalidone, effect, antihypertensive drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chlorthalidone and related drugs may increase the responsiveness to tubocurarine.

Output: <Chlorthalidone, effect, tubocurarine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chlorthalidone and related drugs may decrease arterial responsiveness to norepinephrine.

Output: <Chlorthalidone, effect, norepinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In another drug interaction study, co-administration of orally inhaled ciclesonide and oral ketoconazole, a potent inhibitor of cytochrome P450 3A4, increased the exposure (AUC) of des-ciclesonide by approximately 3.6-fold at steady state, while levels of ciclesonide remained unchanged.

Output: <ciclesonide, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, ketoconazole should be administered with caution with intranasal ciclesonide.

Output: <ketoconazole, advise, ciclesonide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If you are also using a steroid inhaler, take bitolterol first and then wait about 15 minutes before using the steroid inhaler.

Output: <steroid, advise, bitolterol>, <bitolterol, advise, steroid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This allows bitolterol to open air passages, increasing the effectiveness of the steroid.

Output: <bitolterol, effect, steroid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hypotension   Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, as well as those on severe dietary salt restriction or dialysis, may occasionally experience a precipitous reduction of blood pressure usually within the first hour after receiving the initial dose of captopril.

Output: <diuretics, effect, captopril>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The possibility of hypotensive effects with captopril can be minimized by either discontinuing the diuretic or increasing the salt intake approximately one week prior to initiation of treatment with captopril (captopril tablets, USP) or initiating therapy with small doses (6.25 or 12.5 mg).

Output: <captopril, effect, diuretic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: therefore, nitroglycerin or other nitrates (as used for management of angina) or other drugs having vasodilator activity should, if possible, be discontinued before starting captopril.

Output: <nitroglycerin, advise, captopril>, <nitrates, advise, captopril>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Agents Causing Renin Release Captopril's effect will be augmented by antihypertensive agents that cause renin release.

Output: <Captopril, effect, antihypertensive agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta-adrenergic blocking drugs add some further antihypertensive effect to captopril, but the overall response is less than additive.

Output: <Beta-adrenergic blocking drugs, effect, captopril>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Inhibitors Of Endogenous Prostaglandin Synthesis It has been reported that indomethacin may reduce the antihypertensive effect of captopril, especially in cases of low renin hypertension.

Output: <indomethacin, effect, captopril>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy.

Output: <lithium, effect, ACE inhibitor>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If a diuretic is also used, it may increase the risk of lithium toxicity.

Output: <diuretic, effect, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs which may enhance the neuromuscular blocking action of TRACRIUM include: enflurane;

Output: <TRACRIUM, effect, enflurane>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs which may enhance the neuromuscular blocking action of TRACRIUM include: enflurane;isoflurane;halothane;certain antibiotics, especially the aminoglycosides and polymyxins;lithium;magnesium salts;procainamide;and quinidine.

Output: <TRACRIUM, effect, enflurane>, <TRACRIUM, effect, isoflurane>, <TRACRIUM, effect, halothane>, <TRACRIUM, effect, antibiotics>, <TRACRIUM, effect, aminoglycosides>, <TRACRIUM, effect, polymyxins>, <TRACRIUM, effect, lithium>, <TRACRIUM, effect, magnesium>, <TRACRIUM, effect, procainamide>, <TRACRIUM, effect, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The prior administration of succinylcholine does not enhance the duration, but quickens the onset and may increase the depth, of neuromuscular block induced by TRACRIUM.

Output: <succinylcholine, effect, TRACRIUM>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: TRACRIUM should not be administered until a patient has recovered from succinylcholine-induced neuromuscular block.

Output: <TRACRIUM, advise, succinylcholine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Potential drug interactions for doxylamine include, increased sedation if doxylamine is combined with other CNS depressant drugs.

Output: <doxylamine, effect, CNS depressant drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antihistamines may partially counteract the anticoagulation effects of heparin or warfarin.

Output: <Antihistamines, effect, heparin>, <Antihistamines, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Doxylamine may enhance the effects of epinephrine.

Output: <Doxylamine, effect, epinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The use of NSAIDs in patients who are receiving ACE inhibitors may potentiate renal disease states.

Output: <NSAIDs, effect, ACE inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of naproxen and aspirin is not recommended because naproxen is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations and peak plasma levels.

Output: <naproxen, advise, aspirin>, <naproxen, advise, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Naproxen and other NSAIDs can reduce the antihypertensive effect of propranolol and other beta-blockers.

Output: <Naproxen, effect, propranolol>, <Naproxen, effect, beta-blockers>, <NSAIDs, effect, propranolol>, <NSAIDs, effect, beta-blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly.

Output: <Probenecid, mechanism, naproxen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be used if naproxen is administered concomitantly with methotrexate.

Output: <naproxen, advise, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Naproxen, naproxen sodium and other NSAIDs have been reported to reduce the tubular secretion of methotrexate in an animal model, possibly increasing the toxicity of methotrexate.

Output: <Naproxen, mechanism, methotrexate>, <naproxen sodium, mechanism, methotrexate>, <NSAIDs, mechanism, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If CEFOTAN and an aminoglycoside are used concomitantly, renal function should be carefully monitored, because nephrotoxicity may be potentiated.

Output: <CEFOTAN, effect, aminoglycoside>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Colchicine is inhibited by acidifying agents.

Output: <Colchicine, mechanism, acidifying agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The action of colchicine is potentiated by alkalinizing agents.

Output: <colchicine, mechanism, alkalinizing agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Colchicine may increase sensitivity to the CNS depressants.

Output: <Colchicine, effect, CNS depressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Response to sympathomimetic agents may be enhanced by colchicine.

Output: <sympathomimetic agents, effect, colchicine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anagrelide alone had no effect on platelet aggregation, but did slightly enhance the inhibition of platelet aggregation by aspirin.

Output: <Anagrelide, effect, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is known that CYP1A2 is inhibited by several medicinal products, including fluvoxamine, and such medicinal products could theoretically adversely influence the clearance of anagrelide.

Output: <fluvoxamine, mechanism, anagrelide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anagrelide demonstrates some limited inhibitory activity towards CYP1A2 which may present a theoretical potential for interaction with other coadministered medicinal products sharing that clearance mechanism e.g. theophylline.

Output: <Anagrelide, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The effects of medicinal products with similar properties such as inotropes milrinone, enoximone, amrinone, olprinone and cilostazol may be exacerbated by anagrelide.

Output: <milrinone, effect, anagrelide>, <enoximone, effect, anagrelide>, <amrinone, effect, anagrelide>, <olprinone, effect, anagrelide>, <cilostazol, effect, anagrelide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There is a single case report, which suggests that sucralfate may interfere with anagrelide absorption.

Output: <sucralfate, mechanism, anagrelide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: FLUOTHANE augments the action of non-depolarising muscle relaxants and the muscle relaxant effects of aminoglycosides.

Output: <FLUOTHANE, effect, non-depolarising muscle relaxant>, <FLUOTHANE, effect, aminoglycosides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: FLUOTHANE may augment the hypotension caused by the ganglionic-blocking effect of tubocurarine.

Output: <FLUOTHANE, effect, tubocurarine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be exercised during the administration of adrenaline to patients anaesthetised with FLUOTHANE as arrhythmias may be precipitated.

Output: <adrenaline, advise, FLUOTHANE>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Vitamin A: Because of the relationship of Accutane to vitamin A, patients should be advised against taking vitamin supplements containing vitamin A to avoid additive toxic effects

Output: <Accutane, effect, vitamin A>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tetracyclines: Concomitant treatment with Accutane and tetracyclines should be avoided because Accutane use has been associated with a number of cases of pseudotumor cerebri (benign intracranial hypertension), some of which involved concomitant use of tetracyclines

Output: <Accutane, advise, tetracyclines>, <Accutane, effect, tetracyclines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Micro-dosed Progesterone Preparations: Micro-dosed progesterone preparations (minipills that do not contain an estrogen) may be an inadequate method of contraception during Accutane therapy.

Output: <progesterone, effect, Accutane>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents.

Output: <reserpine, effect, beta-blocking>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine.

Output: <beta-blockers, advise, clonidine>, <beta-blocker, advise, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function.

Output: <calcium antagonists, advise, beta-adrenergic blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen.

Output: <beta-adrenergic blocking agents, effect, calcium antagonist>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks.

Output: <beta-blockers, effect, epinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The potential for increased sedation when guanfacine is given with other CNS-depressant drug should be appreciated.

Output: <guanfacine, effect, CNS-depressant drug>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The administration of guanfacine concomitantly with known microsomal enzyme inducer (phenobarbital or phenytoin) to two patients with renal impairment reportedly resulted in significant reductions in elimination half-life and plasma concentration.

Output: <guanfacine, mechanism, phenobarbital>, <guanfacine, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: TCAs decrease the hypotensive effect of guanfacine.

Output: <TCAs, effect, guanfacine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Noncardioselective beta-blockers (nadolol,porpranolol,timolol) may exacerbate rebound hypertension when guanfacine is withdrawn.

Output: <Noncardioselective beta-blockers, effect, guanfacine>, <nadolol, effect, guanfacine>, <timolol, effect, guanfacine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.

Output: <SSRI, int, TCA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nevertheless, caution is indicated in the co-administration of T.A. with any of the SSRIs and also in switching from one class to the other.

Output: <T.A., advise, SSRIs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If desipramine hydrochloride is to be combined with other psychotropic agents such as tranquilizers or sedative/hypnotics, careful consideration should be given to the pharmacology of the agents employed since the sedative effects of desipramine and benzodiazepines (e.g., chlordiazepoxide or diazepam) are additive.

Output: <desipramine hydrochloride, effect, psychotropic agents>, <desipramine hydrochloride, effect, tranquilizers>, <desipramine hydrochloride, effect, sedative>, <desipramine hydrochloride, effect, hypnotics>, <desipramine, effect, benzodiazepines>, <desipramine, effect, chlordiazepoxide>, <desipramine, effect, diazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Both the sedative and anticholinergic effects of the major tranquilizers are also additive to those of desipramine.

Output: <major tranquilizers, effect, desipramine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent administration of cimetidine and tricyclic antidepressants can produce clinically significant increases in the plasma levels of the tricyclic antidepressants.

Output: <cimetidine, mechanism, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Conversely, decreases in plasma levels of the tricyclic antidepressants have been reported upon discontinuation of cimetidine which may result in the loss of the therapeutic efficacy of the tricyclic antidepressant 6.

Output: <tricyclic antidepressants, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been greater than two-fold increases of previously stable plasma levels of tricyclic antidepressants when fluoxetine has been administered in combination with these agents.

Output: <tricyclic antidepressants, mechanism, fluoxetine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: however, 150 mg of ranitidine q12h for 3 days increased the ceftibuten C max by 23% and ceftibuten AUC by 16%.

Output: <ranitidine, mechanism, ceftibuten>, <ranitidine, mechanism, ceftibuten>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: FLEXERIL may have life-threatening interactions with MAO inhibitors.

Output: <FLEXERIL, int, MAO inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants.

Output: <FLEXERIL, effect, alcohol>, <FLEXERIL, effect, barbiturates>, <FLEXERIL, effect, CNS depressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tricyclic antidepressants may block the antihypertensive action of guanethidine and similarly acting compounds.

Output: <Tricyclic antidepressants, effect, guanethidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tricyclic antidepressants may enhance the seizure risk in patients taking tramadol

Output: <Tricyclic antidepressants, effect, tramadol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Urinary acidifying agents These agents (ammonium chloride, sodium acid phosphate, etc.) increase the concentration of the ionized species of the amphetamine molecule, thereby increasing urinary excretion.

Output: <ammonium chloride, mechanism, amphetamine>, <sodium acid phosphate, mechanism, amphetamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Adrenergic blockers Adrenergic blockers are inhibited by amphetamines.

Output: <Adrenergic blockers, effect, amphetamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antidepressants, tricyclic Amphetamines may enhance the activity of tricyclic antidepressants or sympathomimetic agents;

Output: <Amphetamines, effect, tricyclic antidepressants>, <Amphetamines, effect, sympathomimetic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain;

Output: <d-amphetamine, mechanism, desipramine>, <d-amphetamine, mechanism, protriptyline>, <d-amphetamine, mechanism, tricyclics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: MAO inhibitors MAOI antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism.

Output: <MAOI antidepressants, mechanism, amphetamine>, <furazolidone, mechanism, amphetamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antihistamines: Amphetamines may counteract the sedative effect of antihistamines.

Output: <Amphetamines, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antihypertensives: Amphetamines may antagonize the hypotensive effects of antihypertensives.

Output: <Amphetamines, effect, antihypertensives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chlorpromazine: Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines and can be used to treat amphetamine poisoning.

Output: <Chlorpromazine, effect, amphetamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ethosuximide: Amphetamines may delay intestinal absorption of ethosuximide.

Output: <Amphetamines, mechanism, ethosuximide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Haloperidol: Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of amphetamines.

Output: <Haloperidol, effect, amphetamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium carbonate: The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate.

Output: <amphetamines, effect, lithium carbonate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Meperidine: Amphetamines potentiate the analgesic effect of meperidine.

Output: <Amphetamines, effect, meperidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methenamine therapy Urinary excretion of amphetamines is increased, and efficacy is reduced by acidifying agents used in methenamine therapy.

Output: <amphetamines, mechanism, methenamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Norepinephrine: Amphetamines enhance the adrenergic effect of norepinephrine.

Output: <Amphetamines, effect, norepinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenobarbital: Amphetamines may delay intestinal absorption of phenobarbital;

Output: <Amphetamines, mechanism, phenobarbital>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin: Amphetamines may delay intestinal absorption of phenytoin;

Output: <Amphetamines, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Propoxyphene: In cases of propoxyphene overdosage, amphetamine CNS stimulation is potentiated and fatal convulsions can occur.

Output: <propoxyphene, effect, amphetamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Veratrum alkaloids: Amphetamines inhibit the hypotensive effect of veratrum alkaloids.

Output: <Amphetamines, effect, veratrum alkaloids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly.

Output: <Intestinal adsorbents, mechanism, Acarbose>, <charcoal, mechanism, Acarbose>, <amylase, mechanism, Acarbose>, <pancreatin, mechanism, Acarbose>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment.

Output: <Acarbose, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin.

Output: <metformin, mechanism, Acarbose>, <Acarbose, mechanism, metformin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclopentolate may interfere with the anti-glaucoma action of carbachol or pilocarpine;

Output: <Cyclopentolate, effect, carbachol>, <Cyclopentolate, effect, pilocarpine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-medications that induce CYP 3A4 (e.g., rifampicin, phenytoin, carbamazepine, phenobarbital, or St. John s wort) may significantly decrease exposure to exemestane.

Output: <rifampicin, mechanism, exemestane>, <phenytoin, mechanism, exemestane>, <carbamazepine, mechanism, exemestane>, <phenobarbital, mechanism, exemestane>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A case report of one patient taking amiodarone 200 mg and indinavir 800 mg three times a day resulted in increases in amiodarone concentrations from 0.9 mg/L to 1.3 mg/L.

Output: <amiodarone, mechanism, indinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Monitoring for amiodarone toxicity and serial measurement of amiodarone serum concentration during concomitant protease inhibitor therapy should be considered.

Output: <amiodarone, advise, protease inhibitor>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Histamine H2 antagonists: Cimetidine inhibits CYP3A4 and can increase serum amiodarone levels.

Output: <Histamine H2 antagonists, mechanism, Cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: On administration of oral amiodarone, the need for digitalis therapy should be reviewed and the dose reduced by approximately 50% or discontinued.

Output: <amiodarone, advise, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nafazodone, fluvoxamine, cimetidine (consider Xanax dose reduction).

Output: <Nafazodone, advise, Xanax>, <fluvoxamine, advise, Xanax>, <cimetidine, advise, Xanax>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of calcium supplements and L-lysine may increase calcium absorption

Output: <calcium, mechanism, L-lysine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly within14 days following use of monoamine oxidase inhibitors.

Output: <sympathomimetic amines, effect, monoamine oxidase inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: DIDREX should not be used concomitantly with other CNS stimulants.

Output: <DIDREX, advise, CNS stimulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Amphetamines may decrease the hypotensive effect of antihypertensives.

Output: <Amphetamines, effect, antihypertensives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Amphetamines may enhance the effects of tricyclic antidepressants.

Output: <Amphetamines, effect, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Urinary acidifying agents decrease blood levels and increase excretion of amphetamines.

Output: <Urinary acidifying, mechanism, amphetamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In one survey, 2.3% of patients taking labetalol HCl in combination with tricyclic antidepressants experienced tremor, as compared to 0.7% reported to occur with labetalol HCl alone.

Output: <labetalol HCl, effect, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine has been shown to increase the bioavailability of labetalol HCl.

Output: <Cimetidine, mechanism, labetalol HCl>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Synergism has been shown between halothane anesthesia and intravenously administered labetalol HCl.

Output: <halothane, effect, labetalol HCl>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: During controlled hypotensive anesthesia using labetalol HCl in association with halothane, high concentrations (3% or above) of halothane should not be used because the degree of hypotension will be increased and because of the possibility of a large reduction in cardiac output and an increase in central venous pressure.

Output: <labetalol HCl, effect, halothane>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Labetalol HCl blunts the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effect.

Output: <Labetalol HCl, effect, nitroglycerin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If labetalol HCl is used with nitroglycerin in patients with angina pectoris, additional antihypertensive effects may occur.

Output: <labetalol HCl, effect, nitroglycerin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Care should be taken if labetalol is used concomitantly with calcium antagonists of the verapamil type.

Output: <labetalol, advise, calcium antagonist>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In clinical trials in patients undergoing PTCA/PCI, co-administration of Angiomax with heparin, warfarin, thrombolytics or glycoprotein IIb/IIIa inhibitors was associated with increased risks of major bleeding events compared to patients not receiving these concomitant medications.

Output: <Angiomax, effect, heparin>, <Angiomax, effect, warfarin>, <Angiomax, effect, thrombolytics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension.

Output: <epinephrine, effect, monoamine oxidase inhibitors>, <epinephrine, effect, tricyclic antidepressants>, <norepinephrine, effect, monoamine oxidase inhibitors>, <norepinephrine, effect, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine.

Output: <Phenothiazines, effect, epinephrine>, <butyrophenones, effect, epinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drug Interactions with Beta-Blockers: Concomitant use of fenoldopam with beta-blockers should be avoided.

Output: <fenoldopam, advise, beta-blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Apraclonidine should not be used in patients receiving MAO inhibitors..

Output: <Apraclonidine, advise, MAO inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although no specific drug interactions with topical glaucoma drugs or systemic medications were identified in clinical studies of IOPIDINE 0.5% Ophthalmic Solution, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, anesthetics) should be considered.

Output: <IOPIDINE, advise, CNS depressants>, <IOPIDINE, advise, alcohol>, <IOPIDINE, advise, barbiturates>, <IOPIDINE, advise, opiates>, <IOPIDINE, advise, sedatives>, <IOPIDINE, advise, anesthetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.

Output: <Tricyclic antidepressants, effect, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: An additive hypotensive effect has been reported with the combination of systemic clonidine and neuroleptic therapy.

Output: <clonidine, effect, neuroleptic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since apraclonidine may reduce pulse and blood pressure, caution in using drugs such as beta-blockers (ophthalmic and systemic), antihypertensives, and cardiac glycosides is advised.

Output: <apraclonidine, advise, beta-blockers>, <apraclonidine, advise, antihypertensives>, <apraclonidine, advise, cardiac glycosides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When Bezalip or Bezalip retard is used at the same time as other medicines or substances the following interactions must be taken into account: - Bezalip and Bezalip retard may enhance the action of anticoagulants of the coumarin type.

Output: <Bezalip, effect, anticoagulants of the coumarin type>, <Bezalip retard, effect, anticoagulants of the coumarin type>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: For this reason, the dose of the anticoagulant should be reduced by 30 - 50% at the start of treatment with Bezalip or Bezalip retard and then titrated according to the blood clotting parameters

Output: <anticoagulant, advise, Bezalip>, <anticoagulant, advise, Bezalip>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - The action of sulphonylureas and insulin may be enhanced by Bezalip or Bezalip retard.

Output: <sulphonylureas, effect, Bezalip>, <sulphonylureas, effect, Bezalip retard>, <insulin, effect, Bezalip>, <insulin, effect, Bezalip retard>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - In isolated cases, a pronounced though reversible, impairment of renal function (accompanied by a corresponding increase in the serum creatinine level) has been reported in organ transplant patients receiving immuno-suppressant therapy and concomitant bezafibrate.

Output: <immuno-suppressant, effect, bezafibrate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - When Bezalip or Bezalip retard is used concurrently with anion-exchange resins (e.g. cholestryramine), an interval of at least 2 hours should be maintained between the two medicines, since the absorption of Bezalip or Bezalip retard is impaired

Output: <Bezalip, advise, anion-exchange resins>, <Bezalip, advise, cholestryramine>, <Bezalip retard, advise, anion-exchange resins>, <Bezalip retard, advise, cholestryramine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Perhexiline hydrogen maleate or MAO-inhibitors (with hepatotoxic potential) must not be administered together with Bezalip or Bezalip retard.

Output: <Perhexiline hydrogen maleate, advise, Bezalip>, <Perhexiline hydrogen maleate, advise, Bezalip retard>, <MAO-inhibitors, advise, Bezalip>, <MAO-inhibitors, advise, Bezalip retard>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although there are no study data to evaluate the possibility, nitric oxide donor compounds, including sodium nitroprusside and nitroglycerin, may have an additive effect with INOmax on the risk of developing methemoglobinemia.

Output: <nitric oxide donor compounds, effect, INOmax>, <sodium nitroprusside, effect, INOmax>, <nitroglycerin, effect, INOmax>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant oral administration of ketoconazole (a known inhibitor of CYP3A4 activity in the liver and in the intestinal mucosa) caused an eight-fold increase of the systemic exposure to oral budesonide.

Output: <ketoconazole, mechanism, budesonide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If treatment with inhibitors of CYP3A4 activity (such as ketoconazole, intraconazole, ritonavir, indinavir, saquinavir, erythromycin, etc.) is indicated, reduction of the budesonide dose should be considered.

Output: <ketoconazole, advise, budesonide>, <intraconazole, advise, budesonide>, <ritonavir, advise, budesonide>, <indinavir, advise, budesonide>, <saquinavir, advise, budesonide>, <erythromycin, advise, budesonide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tagamet, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline and metronidazole, thereby delaying elimination and increasing blood levels of these drugs.

Output: <Tagamet, mechanism, warfarin-type anticoagulants>, <Tagamet, mechanism, phenytoin>, <Tagamet, mechanism, propranolol>, <Tagamet, mechanism, nifedipine>, <Tagamet, mechanism, chlordiazepoxide>, <Tagamet, mechanism, diazepam>, <Tagamet, mechanism, tricyclic antidepressants>, <Tagamet, mechanism, lidocaine>, <Tagamet, mechanism, theophylline>, <Tagamet, mechanism, metronidazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: therefore, close monitoring of prothrombin time is recommended, and adjustment of the anticoagulant dose may be necessary when Tagamet is administered concomitantly.

Output: <anticoagulant, advise, Tagamet>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, a crossover study in healthy subjects receiving either Tagamet 300 mg q.i.d. or 800 mg h.s. concomitantly with a 300 mg b.i.d. dosage of theophylline (Theo-Dur , Key Pharmaceuticals, Inc.) demonstrated less alteration in steady-state theophylline peak serum levels with the 800 mg h.s. regimen, particularly in subjects aged 54 years and older.

Output: <Tagamet, mechanism, theophylline>, <Tagamet, mechanism, Theo-Dur>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of ELLENCE with other cardioactive compounds that could cause heart failure (e.g., calcium channel blockers), requires close monitoring of cardiac function throughout treatment.

Output: <ELLENCE, advise, calcium channel blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine increased the AUC of epirubicin by 50%.

Output: <Cimetidine, mechanism, epirubicin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine treatment should be stopped during treatment with ELLENCE.

Output: <Cimetidine, advise, ELLENCE>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: MAO inhibitors prolong and intensify the effects of antihistamines.

Output: <MAO inhibitors, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of antihistamines with alcohol, tricyclic antidepressants, barbiturates, or other central nervous system depressants may have an additive effect.

Output: <antihistamines, effect, alcohol>, <antihistamines, effect, tricyclic antidepressants>, <antihistamines, effect, barbiturates>, <antihistamines, effect, central nervous system depressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When sympathomimetic drugs are given to patients receiving monoamine oxidase inhibitors, hypertensive reactions, including hypertensive crises, may occur.

Output: <sympathomimetic drugs, effect, monoamine oxidase inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The antihypertensive effects of methyldopa, mecamylamine, reserpine, and veratrum alkaloids may be reduced by sympathomimetics.

Output: <methyldopa, effect, sympathomimetics>, <mecamylamine, effect, sympathomimetics>, <reserpine, effect, sympathomimetics>, <veratrum alkaloids, effect, sympathomimetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta-adrenergic blocking agents may also interact with sympathomimetics.

Output: <Beta-adrenergic blocking agents, int, sympathomimetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Increased ectopic pacemaker activity can occur when pseudoephedrine is used concomitantly with digitalis.

Output: <pseudoephedrine, effect, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids increase the rate of absorption of pseudoephedrine, while kaolin decreases it.

Output: <Antacids, mechanism, pseudoephedrine>, <pseudoephedrine, mechanism, kaolin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dexbrompheniramine can interact with alcohol or other CNS depressants (may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).

Output: <Dexbrompheniramine, int, alcohol>, <Dexbrompheniramine, int, CNS depressants>, <Dexbrompheniramine, int, anticholinergics>, <Dexbrompheniramine, int, monoamine oxidase (MAO) inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a Phase I trial using escalating doses of TAXOL (110-200 mg/m2) and cisplatin (50 or 75 mg/m2) given as sequential infusions, myelosuppression was more profound when TAXOL was given after cisplatin than with the alternate sequence (ie, TAXOL before cisplatin).

Output: <TAXOL, effect, cisplatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pharmacokinetic data from these patients demonstrated a decrease in paclitaxel clearance of approximately 33% when TAXOL was administered following cisplatin.

Output: <TAXOL, mechanism, cisplatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Reports in the literature suggest that plasma levels of doxorubicin (and its active metabolite doxorubicinol) may be increased when paclitaxel and doxorubicin are used in combination.

Output: <paclitaxel, mechanism, doxorubicin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hypersensitivity Reactions: Patients with a history of severe hypersensitivity reactions to products containing Cremophor  EL (eg, cyclosporin for injection concentrate and teniposide for injection concentrate) should not be treated with TAXOL.

Output: <cyclosporin, advise, TAXOL>, <teniposide, advise, TAXOL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Immediate and Extended Release Tablets The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, some azoles and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents.

Output: <sulfonylureas, effect, nonsteroidal anti-inflammatory agents>, <sulfonylureas, effect, azoles>, <sulfonylureas, effect, salicylates>, <sulfonylureas, effect, sulfonamides>, <sulfonylureas, effect, chloramphenicol>, <sulfonylureas, effect, probenecid>, <sulfonylureas, effect, coumarins>, <sulfonylureas, effect, monoamine oxidase inhibitors>, <sulfonylureas, effect, beta adrenergic blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported.

Output: <miconazole, int, hypoglycemic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The effect of concomitant administration of fluconazole and glipizide has been demonstrated in a placebo-controlled crossover study in normal volunteers.

Output: <fluconazole, int, glipizide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The mean percentage increase in the glipizide AUC after fluconazole administration was 56.9% (range: 35 to 81).

Output: <glipizide, mechanism, fluconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Interactions may occur with the following: adrenocorticoids (cortisone-like medicine), anticoagulants (blood thinners), carbamazepine, corticotropin (barbiturates may decrease the effects of these medicines), central nervous system (CNS) depressants (using these medicines with barbiturates may result in increased CNS depressant effects), divalproex sodium, valproic acid (using these medicines with barbiturates may change the amount of either medicine that you need to take), and oral contraceptives containing estrogens (barbiturates may decrease the effectiveness of these oral contraceptives, and you may need to change to a different type of birth control).

Output: <barbiturates, effect, contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ACE-inhibitors Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors.

Output: <NSAIDs, effect, ACE-inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.

Output: <NSAIDs, advise, ACE-inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: When Lodine is administered with aspirin, its protein binding is reduced, although the clearance of free etodolac is not altered.

Output: <Lodine, mechanism, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: however, as with other NSAIDs, concomitant administration of Lodine and aspirin is not generally recommended because of the potential of increased adverse effects.

Output: <Lodine, advise, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporine, Digoxin, Methotrexate Lodine, like other NSAIDs, through effects on renal prostaglandins, may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine, digoxin, methotrexate, and increased toxicity.

Output: <Lodine, mechanism, cyclosporine>, <Lodine, mechanism, digoxin>, <Lodine, mechanism, methotrexate>, <NSAIDs, mechanism, cyclosporine>, <NSAIDs, mechanism, digoxin>, <NSAIDs, mechanism, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nevertheless, clinical studies, as well as postmarketing observations have shown that Lodine can reduce the natriuretic effect of furosemide and thiazides in some patients.

Output: <Lodine, effect, furosemide>, <Lodine, effect, thiazides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.

Output: <NSAIDs, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Output: <NSAIDs, effect, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenylbutazone: Phenylbutazone causes increase (by about 80%) in the free fraction of etodolac.

Output: <Phenylbutazone, mechanism, etodolac>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although in vivo studies have not been done to see if etodolac clearance is changed by coadministration of phenylbutazone, it is not recommended that they be coadministered.

Output: <etodolac, advise, phenylbutazone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than that of users of either drug alone.

Output: <warfarin, effect, NSAIDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Short-term pharmacokinetic studies have demonstrated that concomitant administration of warfarin and Lodine  (etodolac capsules and tablets) results in reduced protein binding of warfarin, but there was no change in the clearance of free warfarin.

Output: <warfarin, mechanism, Lodine>, <warfarin, mechanism, etodolac>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, caution should be exercised because there have been a few spontaneous reports of prolonged prothrombin times, with or without bleeding, in etodolac-treated patients receiving concomitant warfarin therapy.

Output: <etodolac, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients given very high doses (3900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently.

Output: <aspirin, mechanism, nizatidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If additional adrenergic drugs are to be administered by any route, they should be used with caution because the pharmacologically predictable sympathetic effects of BROVANA may be potentiated.

Output: <adrenergic drugs, advise, BROVANA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant treatment with methylxanthines (aminophylline, theophylline), steroids, or diuretics may potentiate any hypokalemic effect of adrenergic agonists.

Output: <methylxanthines, effect, adrenergic agonists>, <aminophylline, effect, adrenergic agonists>, <theophylline, effect, adrenergic agonists>, <steroids, effect, adrenergic agonists>, <diuretics, effect, adrenergic agonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The ECG changes and/or hypokalemia that may result from the administration of non-potassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded.

Output: <non-potassium sparing diuretics, effect, beta-agonists>, <loop diuretics, effect, beta-agonists>, <thiazide diuretics, effect, beta-agonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although the clinical significance of these effects is not known, caution is advised in the co-administration of beta-agonists with non-potassium sparing diuretics.

Output: <beta-agonists, advise, non-potassium sparing diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: BROVANA, as with other beta2-agonists, should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors, tricyclic antidepressants, or drugs known to prolong the QTc interval because the action of adrenergic agonists on the cardiovascular system may be potentiated by these agents.

Output: <BROVANA, advise, monoamine oxidase inhibitors>, <BROVANA, advise, tricyclic antidepressants>, <beta2-agonists, advise, monoamine oxidase inhibitors>, <beta2-agonists, advise, tricyclic antidepressants>, <monoamine oxidase inhibitors, effect, adrenergic agonists>, <tricyclic antidepressants, effect, adrenergic agonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta-adrenergic receptor antagonists (beta-blockers) and BROVANA may interfere with the effect of each other when administered concurrently.

Output: <Beta-adrenergic receptor antagonists, effect, BROVANA>, <beta-blockers, effect, BROVANA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta-blockers not only block the therapeutic effects of beta-agonists, but may produce severe bronchospasm in COPD patients.

Output: <Beta-blockers, effect, beta-agonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Additive CNS depression may occur when antihistamines are administered concomitantly with other CNS depressants including barbiturates, tranquilizers, and alcohol.

Output: <antihistamines, effect, CNS depressants>, <antihistamines, effect, barbiturates>, <antihistamines, effect, tranquilizers>, <antihistamines, effect, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients receiving antihistamines should be advised against the concurrent use of other CNS depressant drugs.

Output: <antihistamines, advise, CNS depressant drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Monoamine oxidase (MAO) inhibitors prolong and intensify the anticholinergic effects of antihistamines.

Output: <Monoamine oxidase (MAO) inhibitors, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of doxapram to patients who are receiving sympathomimetic or monoamine oxidase inhibiting drugs may result in an additive pressor effect .

Output: <doxapram, effect, sympathomimetic>, <doxapram, effect, monoamine oxidase inhibiting drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients who have received muscle relaxants, doxapram may temporarily mask the residual effects of muscle relaxant drugs.

Output: <doxapram, effect, muscle relaxant drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The effects of ERGOMAR may be potentiated by triacetyloleandomycin which inhibits the metabolism of ergotamine.

Output: <ERGOMAR, mechanism, triacetyloleandomycin>, <triacetyloleandomycin, mechanism, ergotamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The pressor effects of ERGOMAR and other vasoconstrictor drugs can combine to cause dangerous hypertension.

Output: <ERGOMAR, effect, vasoconstrictor drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Synergism between xanthine bronchodilators (e.g., theophylline), ephedrine, and other sympathomimetic bronchodilators has been reported.

Output: <xanthine bronchodilators, effect, sympathomimetic bronchodilators>, <theophylline, effect, sympathomimetic bronchodilators>, <ephedrine, effect, sympathomimetic bronchodilators>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent administration of dyphylline and probenecid, which competes for tubular secretion, has been shown to increase the plasma half-life of dyphylline .

Output: <dyphylline, mechanism, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, in patients treated with oral carbonic anhydrase inhibitors, rare instances of drug interactions have occurred with high-dose salicylate therapy.

Output: <carbonic anhydrase inhibitors, int, salicylate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Effect of AEDs in Pediatric Patients There was about a 22% increase of apparent total body clearance of levetiracetam when it was co-administered with enzyme-inducing AEDs.

Output: <levetiracetam, mechanism, AEDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When ertapenem is co-administered with probenecid (500 mg p.o. every 6 hours), probenecid competes for active tubular secretion and reduces the renal clearance of ertapenem.

Output: <probenecid, mechanism, ertapenem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Based on total ertapenem concentrations, probenecid increased the AUC by 25% and reduced the plasma and renal clearances by 20% and 35%, respectively.

Output: <ertapenem, mechanism, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because of the small effect on half-life, the coadministration with probenecid to extend the half-life of ertapenem is not recommended.

Output: <probenecid, advise, ertapenem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Using calcium acetate with digitalis glycosides (heart medicine) may cause hypercalcemia (too much calcium in the blood), which could increase the chance of developing an irregular heartbeat.

Output: <calcium acetate, effect, digitalis glycosides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: On the basis of the metabolism of bexarotene by cytochrome P450 3A4, ketoconazole, itraconazole, erythromycin, gemfibrozil, grapefruit juice, and other inhibitors of cytochrome P450 3A4 would be expected to lead to an increase in plasma bexarotene concentrations.

Output: <ketoconazole, mechanism, bexarotene>, <itraconazole, mechanism, bexarotene>, <erythromycin, mechanism, bexarotene>, <gemfibrozil, mechanism, bexarotene>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furthermore, rifampin, phenytoin, phenobarbital, and other inducers of cytochrome P450 3A4 may cause a reduction in plasma bexarotene concentrations.

Output: <rifampin, mechanism, bexarotene>, <phenytoin, mechanism, bexarotene>, <phenobarbital, mechanism, bexarotene>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of Targretin capsules and gemfibrozil resulted in substantial increases in plasma concentrations of bexarotene, probably at least partially related to cytochrome P450 3A4 inhibition by gemfibrozil.

Output: <Targretin, mechanism, gemfibrozil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of gemfibrozil with Targretin capsules is not recommended.

Output: <gemfibrozil, advise, Targretin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If phenytoin or other hepatic enzyme inducers are taken concurrently with Norpace or Norpace CR, lower plasma levels of disopyramide may occur.

Output: <phenytoin, mechanism, Norpace>, <phenytoin, mechanism, Norpace CR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of Norpace and quinidine resulted in slight increases in plasma disopyramide levels and slight decreases in plasma quinidine levels.

Output: <Norpace, mechanism, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients taking disopyramide phosphate and erythromycin concomitantly may develop increased serum concentrations of disopyramide resulting in excessive widening of the QRS complex and/or prolongation of the Q-T interval.

Output: <disopyramide phosphate, mechanism, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Until data on possible interactions between verapamil and disopyramide phosphate are obtained, disopyramide should not be administered within 48 hours before or 24 hours after verapamil administration.

Output: <disopyramide, advise, verapamil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Taking amyl nitrite after drinking alcohol may worsen side effects and may cause severe hypotension and cardiovascular collapse.

Output: <amyl nitrite, effect, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: 5HT3 Antagonists: Based on reports of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron, the concomitant use of apomorphine with drugs of the 5HT3 antagonist class (including, for example, ondansetron, granisetron, dolasetron, palonosetron, and alosetron) is contraindicated .

Output: <apomorphine, effect, ondansetron>, <apomorphine, advise, 5HT3 antagonist class>, <apomorphine, advise, ondansetron>, <apomorphine, advise, granisetron>, <apomorphine, advise, dolasetron>, <apomorphine, advise, palonosetron>, <apomorphine, advise, alosetron>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antihypertensive Medications and Vasodilators: The following adverse events were experienced more commonly in patients receiving concomitant antihypertensive medications or vasodilators (n = 94) compared to patients not receiving these concomitant drugs (n = 456): hypotension 10% vs 4%, myocardial infarction 3% vs 1%, serious pneumonia 5% vs 3%, serious falls 9% vs 3%, and bone and joint injuries 6% vs 2%.

Output: <antihypertensive medications, effect, vasodilators>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dopamine Antagonists: Since apomorphine is a dopamine agonist, it is possible that dopamine antagonists, such as the neuroleptics (phenothiazines, butyrophenones, thioxanthenes) or metoclopramide, may diminish the effectiveness of APOKYN.

Output: <dopamine antagonists, effect, metoclopramide>, <phenothiazines, effect, APOKYN>, <butyrophenones, effect, APOKYN>, <thioxanthenes, effect, APOKYN>, <metoclopramide, effect, APOKYN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients with major psychotic disorders, treated with neuroleptics, should be treated with dopamine agonists only if the potential benefits outweigh the risks.

Output: <neuroleptics, advise, dopamine agonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension.

Output: <epinephrine, effect, monoamine oxidase inhibitors>, <epinephrine, effect, tricyclic antidepressants>, <norepinephrine, effect, monoamine oxidase inhibitors>, <norepinephrine, effect, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine.

Output: <Phenothiazines, effect, epinephrine>, <butyrophenones, effect, epinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drug-Drug Interactions Given the primary CNS effects of aripiprazole, caution should be used when ABILIFY is taken in combination with other centrally acting drugs and alcohol.

Output: <ABILIFY, advise, centrally acting drugs>, <ABILIFY, advise, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: 1- adrenergic receptor antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents.

Output: <aripiprazole, effect, antihypertensive agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Agents that induce CYP3A4 (eg, carbamazepine) could cause an increase in aripiprazole clearance and lower blood levels.

Output: <carbamazepine, mechanism, aripiprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit aripiprazole elimination and cause increased blood levels.

Output: <ketoconazole, mechanism, aripiprazole>, <quinidine, mechanism, aripiprazole>, <fluoxetine, mechanism, aripiprazole>, <paroxetine, mechanism, aripiprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: Coadministration of ketoconazole (200 mg/day for 14 days) with a 15-mg single dose of aripiprazole increased the AUC of aripiprazole and its active metabolite by 63% and 77%, respectively.

Output: <ketoconazole, mechanism, aripiprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When concomitant administration of ketoconazole with aripiprazole occurs, aripiprazole dose should be reduced to one-half of its normal dose.

Output: <ketoconazole, advise, aripiprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Quinidine: Coadministration of a 10-mg single dose of aripiprazole with quinidine (166 mg/day for 13 days), a potent inhibitor of CYP2D6, increased the AUC of aripiprazole by 112% but decreased the AUC of its active metabolite, dehydroaripiprazole, by 35%.

Output: <aripiprazole, mechanism, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aripiprazole dose should be reduced to one-half of its normal dose when concomitant administration of quinidine with aripiprazole occurs.

Output: <quinidine, advise, aripiprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Carbamazepine: Coadministration of carbamazepine (200 mg BID), a potent CYP3A4 inducer, with aripiprazole (30 mg QD) resulted in an approximate 70% decrease in Cmax and AUC values of both aripiprazole and its active metabolite, dehydro-aripiprazole.

Output: <carbamazepine, mechanism, aripiprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When carbamazepine is added to aripiprazole therapy, aripiprazole dose should be doubled.

Output: <carbamazepine, advise, aripiprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When carbamazepine is withdrawn from the combination therapy, aripiprazole dose should then be reduced.

Output: <carbamazepine, advise, aripiprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: As with most psychoactive medications, patients should be advised to avoid alcohol while taking ABILIFY

Output: <alcohol, advise, ABILIFY>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dexbrompheniramine can interact with alcohol or other CNS depressants (may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).

Output: <Dexbrompheniramine, effect, alcohol>, <Dexbrompheniramine, effect, CNS depressants>, <Dexbrompheniramine, effect, anticholinergics>, <Dexbrompheniramine, effect, monoamine oxidase (MAO) inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cholestyramine-Concomitant intake of cholestyramine and vitamin K may reduce the absorption of vitamin K.

Output: <cholestyramine, mechanism, vitamin K>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Colestipol-Concomitant intake of colestipol and vitamin K may reduce the absorption of vitamin K.

Output: <colestipol, mechanism, vitamin K>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Mineral Oil-Concomitant intake of mineral oil and vitamin K may reduce the absorption of vitamin K.

Output: <mineral oil, mechanism, vitamin K>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Orlistat-Orlistat may decrease the absorption of vitamin K.

Output: <Orlistat, mechanism, vitamin K>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin-Vitamin K can antagonize the effect of warfarin

Output: <Vitamin K, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticoagulants: Flurbiprofen like other nonsteroidal anti-inflammatory drugs, has been shown to affect bleeding parameters in patients receiving anti-coagulants, and serious clinical bleeding has been reported.

Output: <Flurbiprofen, effect, anti-coagulants>, <nonsteroidal anti-inflammatory drugs, effect, anti-coagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The physician should be cautious when administering flurbiprofen to patients taking anticoagulants.

Output: <flurbiprofen, advise, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: Concurrent administration of aspirin and flurbiprofen resulted in 50% lower serum flurbiprofen concentrations.

Output: <aspirin, mechanism, flurbiprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent use of flurbiprofen and aspirin is therefore not recommended.

Output: <flurbiprofen, advise, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Flurbiprofen pretreatment attenuated the hypotensive effect of a single dose of propranolol but not atenolol.

Output: <Flurbiprofen, effect, propranolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Flurbiprofen did not affect the pharmacokinetic profile of either drug, and the mechanism under lying the interference with propranolols hypotensive effect is unknown.

Output: <Flurbiprofen, int, propranolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients taking both flurbiprofen and a beta-blocker should be monitored to ensure that a satisfactory hypotensive effect is achieved.

Output: <flurbiprofen, advise, beta-blocker>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine, Ranitidine: In normal volunteers (n=9), pretreatment with cimetidine or ranitidine did not affect flurbiprofen pharmacokinetics except that a small (13 %) but statistically significant increase in the area under the serum concentration curve of flurbiprofen resulted with cimetidine.

Output: <flurbiprofen, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diuretics: Studies in normal volunteers have shown that flurbiprofen like other nonsteroidal anti-inflammatory drugs, can interfere with the effects of furosemide.

Output: <flurbiprofen, effect, furosemide>, <nonsteroidal anti-inflammatory drugs, effect, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other nonsteroidal anti-inflammatory drugs that inhibit prostaglandin synthesis have been shown to interfere with thiazide diuretics in some studies and with potassium-sparing diuretics.

Output: <nonsteroidal anti-inflammatory drugs, effect, thiazide diuretics>, <nonsteroidal anti-inflammatory drugs, effect, potassium-sparing diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients receiving flurbiprofen and furosemide or other diuretics should be observed closely to determine if the desired effect is obtained.

Output: <flurbiprofen, advise, furosemide>, <flurbiprofen, advise, diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although there was a slight reduction in blood sugar concentrations during concomitant administration of flurbiprofen and hypoglycemic agents, there were no signs or symptoms of hypoglycemia.

Output: <flurbiprofen, effect, hypoglycemic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: DISULFIRAM SHOULD BE USED WITH CAUTION IN THOSE PATIENTS REVEIVING PHENYTOIN AND ITS CONGENERS.

Output: <DISULFIRAM, advise, PHENYTOIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: SINCE THE CONCOMITANT ADMINISTRATION OF THESE TWO DRUGS CAN LEAD TO PHENYTOIN INTOXICATION, PRIOR TO ADMINISTERING DISULFIRAM TO A PATIENT ON PHENYTOIN THERAPY, A BASELINE PHENYTOIN SERUM LEVEL SHOULD BE OBTAINED.

Output: <DISULFIRAM, effect, PHENYTOIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It may be necessary to adjust the dosage of oral anticoagulants upon beginning or stopping disulfiram. since disulfiram may prolong prothrombin time.

Output: <anticoagulants, advise, disulfiram>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients taking isoniazid when disulfiram is given should be observed for the appearance of unsteady gait or marked changes in mental status;

Output: <isoniazid, advise, disulfiram>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In rats, simultaneous ingestion of disulfiram and nitrite in the diet for 78 weeks has been reported to cause tumors, and it has been suggested that disulfiram may react with nitrites in the rat stomach to form a nitrosamine, which is tumorigenic.

Output: <disulfiram, effect, nitrite>, <disulfiram, effect, nitrites>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A 30 to 45% increase in AUC and Cmax of nisoldipine was observed with concomitant administration of cimetidine 400 mg twice daily.

Output: <nisoldipine, mechanism, cimetidine 400 mg>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of phenytoin with 40 mg SULAR tablets in epileptic patients lowered the nisoldipine plasma concentrations to undetectable levels.

Output: <phenytoin, mechanism, SULAR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of SULAR with phenytoin or any known CYP3A4 inducer should be avoided and alternative antihypertensive therapy should be considered.

Output: <SULAR, advise, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Propranolol attenuated the heart rate increase following administration of immediate release nisoldipine.

Output: <Propranolol, effect, nisoldipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The blood pressure effect of SULAR tended to be greater in patients on atenolol than in patients on no other antihypertensive therapy.

Output: <SULAR, effect, atenolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Quinidine at 648 mg bid decreased the bioavailability (AUC) of nisoldipine by 26%, but not the peak concentration.

Output: <Quinidine, mechanism, nisoldipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The immediate release, but not the coat-core formulation of nisoldipine increased plasma quinidine concentrations by about 20%.

Output: <nisoldipine, mechanism, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended that buspirone hydrochloride not be used concomitantly with MAO inhibitors Because the effects of concomitant administration of buspirone HCl with most other psychotropic drugs have not been studied, the concomitant use of buspirone HCl with other CNS-active drugs should be approached with caution.

Output: <buspirone hydrochloride, advise, MAO inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There is one report suggesting that the concomitant use of trazodone hydrochloride (Desyrel) and buspirone HCl may have caused 3- to 6-fold elevations on SGPT (ALT) in a few patients.

Output: <trazodone hydrochloride, effect, buspirone HCl>, <Desyrel, effect, buspirone HCl>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a study in normal volunteers, concomitant administration of buspirone HCl and haloperidol resulted in increased serum haloperidol concentrations.

Output: <buspirone HCl, mechanism, haloperidol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, there has been one report of prolonged prothrombin time when buspirone was added to the regimen of a patient treated with warfarin.

Output: <buspirone, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In vitro, buspirone may displace less firmly bound drugs like digoxin.

Output: <buspirone, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of L-phenylalanine and non-selective MAO inhibitors may cause hypertension.

Output: <L-phenylalanine, effect, non-selective MAO inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Selegiline - L-phenylalanine and the selective MAO inhibitor selegiline may have synergistic antidepressant activity if used concomitantly.

Output: <L-phenylalanine, effect, selegiline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Neuroleptic Drugs - L-phenylalanine may potentiate the tardive dyskinesia side reactions of neuroleptic drugs if used concomitantly with them.

Output: <Neuroleptic Drugs, effect, L-phenylalanine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nabilone should be administered with caution to patients who are taking other psychoactive drugs or CNS depressants, including alcohol, barbiturates and narcotic analgesics, or to those with a history of psychiatric disorder (including manic-depressive illness and schizophrenia).

Output: <Nabilone, advise, psychoactive drugs>, <Nabilone, advise, CNS depressants>, <Nabilone, advise, alcohol>, <Nabilone, advise, barbiturates>, <Nabilone, advise, narcotic analgesics>