Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of erythromycin and digoxin has been reported to result in elevated digoxin serum levels.

Output: <erythromycin, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been reports of increased anticoagulant effects when erythromycin and oral anticoagulants were used concomitantly.

Output: <erythromycin, effect, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent use of erythromycin and ergotamine or dihydroergotamine has been associated in some patients with acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia.

Output: <erythromycin, effect, ergotamine>, <erythromycin, effect, dihydroergotamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Erythromycin has been reported to decrease the clearance of triazolam and midazolam and thus may increase the pharmacologic effect of these benzodiazepines.

Output: <Erythromycin, mechanism, triazolam>, <Erythromycin, mechanism, midazolam>, <Erythromycin, effect, benzodiazepines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been reports of interactions of erythromycin with carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfentanil, cisapride, disopyramide, lovastatin, bromocriptine, valproate, terfenadine, and astemizole.

Output: <erythromycin, int, carbamazepine>, <erythromycin, int, cyclosporine>, <erythromycin, int, tacrolimus>, <erythromycin, int, hexobarbital>, <erythromycin, int, phenytoin>, <erythromycin, int, alfentanil>, <erythromycin, int, cisapride>, <erythromycin, int, disopyramide>, <erythromycin, int, lovastatin>, <erythromycin, int, bromocriptine>, <erythromycin, int, valproate>, <erythromycin, int, terfenadine>, <erythromycin, int, astemizole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Erythromycin has been reported to significantly alter the metabolism of nonsedating antihistamines terfenadine and astemizole when taken concomitantly.

Output: <Erythromycin, mechanism, terfenadine>, <Erythromycin, mechanism, astemizole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition, deaths have been reported rarely with concomitant administration of terfenadine and erythromycin.

Output: <terfenadine, effect, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been postmarketing reports of drug interactions when erythromycin is coadministered with cisapride, resulting in QT prolongation, cardiac arrythmias, ventricular tachycardia, ventricular fibrulation, and torsades de pointes, most like due to inhibition of hepatic metabolism of cisapride by erythromycin.

Output: <erythromycin, effect, cisapride>, <cisapride, mechanism, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients receiving concomitant lovastatin and erythromycin should be carefully monitored;

Output: <lovastatin, advise, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

Output: <tetracyclines, advise, anticoagulant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since bacteriostatic drugs, such as the tetracycline class of antibiotics, may interfere with the bactericidal action of penicillins, it is not advisable to administer these drugs concomitantly.

Output: <tetracycline class, effect, penicillins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.

Output: <tetracyclines, effect, contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Increases in prothrombin time have been noted in patients receiving long- term warfarin therapy after flutamide was initiated.

Output: <warfarin, effect, flutamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, close monitoring of prothrombin time is recommended and adjustment of the anticoagulant dose may be necessary when EULEXIN Capsules are administered concomitantly with warfarin.

Output: <EULEXIN, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: in one man, the C max of terfenadine was 8.1 ng/mL with terfenadine alone and 7.2 ng/mL with terfenadine plus dirithromycin.

Output: <terfenadine, mechanism, dirithromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The mean QT c interval (msec) was 369 with terfenadine alone and 367 with terfenadine plus dirithromycin.

Output: <terfenadine, effect, dirithromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus, the interaction observed between erythromycin and terfenadine is not expected for dirithromycin.

Output: <erythromycin, int, terfenadine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Serious cardiac dysrhythmias, some resulting in death, have occurred in patients receiving terfenadine concomitantly with other macrolide antibiotics.

Output: <terfenadine, effect, macrolide antibiotics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition, most macrolides are contraindicated in patients receiving terfenadine therapy who have pre-existing cardiac abnormalities (arrhythmia, bradycardia, QT c interval prolongation, ischemic heart disease, congestive heart failure, etc.) or electrolyte disturbances.

Output: <macrolides, advise, terfenadine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids or H 2 receptor antagonists: When dirithromycin is administered immediately following antacids or H 2 -receptor antagonists, the absorption of dirithromycin is slightly enhanced.

Output: <dirithromycin, mechanism, antacids>, <dirithromycin, mechanism, H 2 -receptor antagonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Triazolam: Erythromycin has been reported to decrease the clearance of triazolam and, thus, may increase the pharmacologic effect of triazolam.

Output: <Erythromycin, mechanism, triazolam>, <Erythromycin, effect, triazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digoxin: Concomitant administration of erythromycin and digoxin has been reported to result in elevated digoxin serum levels.

Output: <erythromycin, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticoagulants: There have been reports of increased anticoagulant effects when erythromycin and oral anticoagulants were used concomitantly.

Output: <erythromycin, effect, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ergotamine: Concurrent use of erythromycin and ergotamine or dihydroergotamine has been associated in some patients with acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia.

Output: <erythromycin, effect, ergotamine>, <erythromycin, effect, dihydroergotamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other drugs Drug interactions have been reported with concomitant administration of erythromycin and other medications, including cyclosporine, hexobarbital, carbamazepine, alfentanil, disopyramide, phenytoin, bromocriptine, valproate, astemizole, and lovastatin.

Output: <erythromycin, int, cyclosporine>, <erythromycin, int, hexobarbital>, <erythromycin, int, carbamazepine>, <erythromycin, int, alfentanil>, <erythromycin, int, disopyramide>, <erythromycin, int, phenytoin>, <erythromycin, int, bromocriptine>, <erythromycin, int, valproate>, <erythromycin, int, astemizole>, <erythromycin, int, lovastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The safety and efficacy of concomitant use of REVIA and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.

Output: <REVIA, effect, disulfiram>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lethargy and somnolence have been reported following doses of REVIA and thioridazine.

Output: <REVIA, effect, thioridazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients taking REVIA may not benefit from opioid containing medicines, such as cough and cold preparations, antidiarrheal preparations, and opioid analgesics.

Output: <REVIA, effect, opioid>, <REVIA, effect, opioid analgesics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In an emergency situation when opioid analgesia must be administered to a patient receiving REVIA, the amount of opioid required may be greater than usual, and the resulting respiratory depression may be deeper and more prolonged.

Output: <REVIA, effect, opioid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cholestyramine and colestipol resins: Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.

Output: <hydrochlorothiazide, mechanism, anionic exchange resins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively.

Output: <cholestyramine, mechanism, hydrochlorothiazide>, <colestipol, mechanism, hydrochlorothiazide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: generally should not be given with diuretics.

Output: <Lithium, advise, diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.

Output: <Diuretic agents, mechanism, lithium>, <Diuretic agents, effect, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Refer to the package insert for lithium preparations before use of such preparations with Hydrochlorothiazide.

Output: <lithium, advise, Hydrochlorothiazide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Non-steroidal Anti-inflammatory Drugs: In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.

Output: <non-steroidal anti-inflammatory agent, effect, loop diuretics>, <non-steroidal anti-inflammatory agent, effect, potassium-sparing diuretics>, <non-steroidal anti-inflammatory agent, effect, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, when Hydrochlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

Output: <Hydrochlorothiazide, advise, non-steroidal anti-inflammatory agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.

Output: <cephalosporins, effect, aminoglycoside antibiotics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients who are applying Panretin gel should not concurrently use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products.

Output: <Panretin, advise, DEET>, <Panretin, advise, N-diethyl-m-toluamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sulfacetamide preparations are incompatible with silver preparations.

Output: <Sulfacetamide, int, silver>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, iloprost has the potential to increase the hypotensive effect of vasodilators and antihypertensive agents.

Output: <iloprost, effect, vasodilators>, <iloprost, effect, antihypertensive agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since iloprost inhibits platelet function, there is a potential for increased risk of bleeding, particularly in patients maintained on anticoagulants.

Output: <iloprost, effect, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: RAPTIVA should not be used with other immunosuppressive drugs.

Output: <RAPTIVA, advise, immunosuppressive drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acellular, live and live-attenuated vaccines should not be administered during RAPTIVA treatment.

Output: <Acellular vaccines, advise, RAPTIVA>, <live vaccines, advise, RAPTIVA>, <live-attenuated vaccines, advise, RAPTIVA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Mineral oil interferes with the absorption of fat-soluble vitamins, including vitamin D preparations.

Output: <Mineral oil, mechanism, fat-soluble vitamins>, <Mineral oil, mechanism, vitamin D preparations>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with ergocalciferol may cause hypercalcemia.

Output: <thiazide diuretics, effect, ergocalciferol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Netilmicin should not be administered concomitantly with potent loop diuretics such as furosemide and ethacrynic acid as the potential for ototoxicity is enhanced by the combination.

Output: <Netilmicin, advise, loop diuretics>, <Netilmicin, advise, furosemide>, <Netilmicin, advise, ethacrynic acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Bentiromide may interact with acetaminophen (e.g., Tylenol), chloramphenicol (e.g., Chloromycetin), local anesthetics (e.g., benzocaine and lidocaine), para-aminobenzoic acid (PABA)-containing preparations (e.g., sunscreens and some multivitamins), procainamide (e.g., Pronestyl), sulfonamides (sulfa medicines), thiazide diuretics (use of these medicines during the test period will affect the test results), and pancreatic supplements (use of pancreatic supplements may give false test results).

Output: <Bentiromide, int, acetaminophen>, <Bentiromide, int, Tylenol>, <Bentiromide, int, chloramphenicol>, <Bentiromide, int, Chloromycetin>, <Bentiromide, int, anesthetics>, <Bentiromide, int, benzocaine>, <Bentiromide, int, lidocaine>, <Bentiromide, int, para-aminobenzoic acid>, <Bentiromide, int, PABA>, <Bentiromide, int, multivitamins>, <Bentiromide, int, procainamide>, <Bentiromide, int, Pronestyl>, <Bentiromide, int, sulfonamides>, <Bentiromide, int, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, the risk of hyperkalemia may be increased.

Output: <amiloride, effect, angiotensin-converting enzyme inhibitor>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.

Output: <Lithium, advise, diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.

Output: <non-steroidal anti-inflammatory agent, effect, loop diuretics>, <non-steroidal anti-inflammatory agent, effect, potassium-sparing diuretics>, <non-steroidal anti-inflammatory agent, effect, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, when MIDAMOR and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

Output: <MIDAMOR, advise, non-steroidal anti-inflammatory agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since indomethacin and potassium-sparing diuretics, including MIDAMOR, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.

Output: <indomethacin, effect, potassium-sparing diuretics>, <indomethacin, effect, MIDAMOR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Drugs with ototoxic potential: Especially in the presence of impaired renal function, the use of parenterally administered bumetanide in patients to whom aminoglycoside antibiotics are also being given should be avoided, except in life-threatening conditions.

Output: <bumetanide, advise, aminoglycoside antibiotics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Lithium: Lithium should generally not be given with diuretics (such as bumetanide) because they reduce its renal clearance and add a high risk of lithium toxicity.

Output: <Lithium, advise, diuretics>, <Lithium, advise, bumetanide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Probenecid: Pretreatment with probenecid reduces both the natriuresis and hyperreninemia produced by bumetanide.

Output: <probenecid, effect, bumetanide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This antagonistic effect of probenecid on bumetanide natriuresis is not due to a direct action on sodium excretion but is probably secondary to its inhibitory effect on renal tubular secretion of bumetanide.

Output: <probenecid, mechanism, bumetanide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus, probenecid should not be administered concurrently with bumetanide.

Output: <probenecid, advise, bumetanide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Indomethacin: Indomethacin blunts the increases in urine volume and sodium excretion seen during bumetanide treatment and inhibits the bumetanide-induced increase in plasma renin activity.

Output: <Indomethacin, mechanism, bumetanide>, <Indomethacin, effect, bumetanide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Antihypertensives: Bumetanide may potentiate the effect of various antihypertensive drugs, necessitating a reduction in the dosage of these drugs.

Output: <Bumetanide, effect, antihypertensive drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents.

Output: <sulfonylureas, effect, nonsteroidal anti-inflammatory agents>, <sulfonylureas, effect, salicylates>, <sulfonylureas, effect, sulfonamides>, <sulfonylureas, effect, chloramphenicol>, <sulfonylureas, effect, probenecid>, <sulfonylureas, effect, coumarins>, <sulfonylureas, effect, monoamine oxidase inhibitors>, <sulfonylureas, effect, beta adrenergic blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A possible interaction between glyburide and ciprofloxacin, a fluoroquinolone antibiotic, has been reported, resulting in a potentiation of the hypoglycemic action of glyburide.

Output: <glyburide, int, ciprofloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported.

Output: <miconazole, effect, hypoglycemic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects an blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide.

Output: <anticoagulants, effect, chlordiazepoxide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Azlocillin should not be administered concomitantly with amikacin, ciprofloxacin, gentamicin, netilmicin, or tobramycin.

Output: <Azlocillin, advise, amikacin>, <Azlocillin, advise, ciprofloxacin>, <Azlocillin, advise, gentamicin>, <Azlocillin, advise, netilmicin>, <Azlocillin, advise, tobramycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ZEBETA should not be combined with other beta-blocking agents.

Output: <ZEBETA, advise, beta-blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients receiving catecholamine-depleting drugs, such as reserpine or guanethidine, should be closely monitored, because the added beta-adrenergic blocking action of ZEBETA may produce excessive reduction of sympathetic activity.

Output: <reserpine, effect, ZEBETA>, <guanethidine, effect, ZEBETA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients receiving concurrent therapy with clonidine, if therapy is to be discontinued, it is suggested that ZEBETA be discontinued for several days before the withdrawal of clonidine.

Output: <ZEBETA, advise, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ZEBETA should be used with care when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide, are used concurrently.

Output: <ZEBETA, advise, myocardial depressants>, <ZEBETA, advise, calcium antagonists>, <ZEBETA, advise, phenylalkylamine>, <ZEBETA, advise, verapamil>, <ZEBETA, advise, benzothiazepine>, <ZEBETA, advise, diltiazem>, <ZEBETA, advise, antiarrhythmic agents>, <ZEBETA, advise, disopyramide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent use of rifampin increases the metabolic clearance of ZEBETA, resulting in a shortened elimination half-life of ZEBETA.

Output: <rifampin, mechanism, ZEBETA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and folic acid.

Output: <vitamin B12, int, folic acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids containing magnesium trisilicate, when administered concomitantly with nitrofurantoin, reduce both the rate and extent of absorption.

Output: <magnesium trisilicate, mechanism, nitrofurantoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The mechanism for this interaction probably is adsorption of nitrofurantoin onto the surface of magnesium trisilicate.

Output: <nitrofurantoin, mechanism, magnesium trisilicate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin.

Output: <Uricosuric drugs, mechanism, nitrofurantoin>, <probenecid, mechanism, nitrofurantoin>, <sulfinpyrazone, mechanism, nitrofurantoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent administration of drugs possessing nephrotoxic (e.g., aminoglycosides, indomethacin), myelotoxic (e.g., cytotoxic chemotherapy), cardiotoxic (e.g., doxorubicin) or hepatotoxic (e.g., methotrexate, asparaginase) effects with PROLEUKIN may increase toxicity in these organ systems.

Output: <aminoglycosides, effect, PROLEUKIN>, <indomethacin, effect, PROLEUKIN>, <cytotoxic, effect, PROLEUKIN>, <doxorubicin, effect, PROLEUKIN>, <methotrexate, effect, PROLEUKIN>, <asparaginase, effect, PROLEUKIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hypersensitivity reactions have been reported in patients receiving combination regimens containing sequential high dose PROLEUKIN and antineoplastic agents, specifically, dacarbazine, cis-platinum, tamoxifen and interferon-alfa.

Output: <PROLEUKIN, effect, antineoplastic agents>, <PROLEUKIN, effect, dacarbazine>, <PROLEUKIN, effect, cis-platinum>, <PROLEUKIN, effect, tamoxifen>, <PROLEUKIN, effect, interferon-alfa>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Myocardial injury, including myocardial infarction, myocarditis, ventricular hypokinesia, and severe rhabdomyolysis appear to be increased in patients receiving PROLEUKIN and interferon-alfa concurrently.

Output: <PROLEUKIN, effect, interferon-alfa>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Exacerbation or the initial presentation of a number of autoimmune and inflammatory disorders has been observed following concurrent use of interferon-alfa and PROLEUKIN, including crescentic IgA glomerulonephritis, oculo-bulbar myasthenia gravis, inflammatory arthritis, thyroiditis, bullous pemphigoid, and Stevens-Johnson syndrome.

Output: <interferon-alfa, effect, PROLEUKIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although glucocorticoids have been shown to reduce PROLEUKIN-induced side effects including fever, renal insufficiency, hyperbilirubinemia, confusion, and dyspnea, concomitant administration of these agents with PROLEUKIN may reduce the antitumor effectiveness of PROLEUKIN and thus should be avoided. 12 Beta-blockers and other antihypertensives may potentiate the hypotension seen with PROLEUKIN.

Output: <glucocorticoids, effect, PROLEUKIN>, <Beta-blockers, effect, PROLEUKIN>, <antihypertensives, effect, PROLEUKIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Delayed Adverse Reactions to Iodinated Contrast Media: A review of the literature revealed that 12.6% (range 11-28%) of 501 patients treated with various interleukin-2 containing regimens who were subsequently administered radiographic iodinated contrast media experienced acute, atypical adverse reactions.

Output: <interleukin-2, effect, radiographic iodinated contrast media>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cevimeline should be administered with caution to patients taking beta adrenergic antagonists, because of the possibility of conduction disturbances.

Output: <Cevimeline, advise, beta adrenergic antagonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aminosalicylic acid may decrease the amount of digoxin (Lanoxin, Lanoxicaps) that gets absorbed into your body.

Output: <Aminosalicylic acid, mechanism, digoxin>, <Aminosalicylic acid, mechanism, Lanoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In the case that you are taking digoxin while taking aminosalicylic acid, higher doses of digoxin may be needed.

Output: <digoxin, advise, aminosalicylic acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aminosalicylic acid may also decrease the absorption of vitamin B12, which can lead to a deficiency.

Output: <Aminosalicylic acid, mechanism, vitamin B12>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore you may need to take a vitamin B12 supplement while taking aminosalicylic acid.

Output: <vitamin B12, advise, aminosalicylic acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: PROSTIN E2 may augment the activity of other oxytocic drugs.

Output: <PROSTIN E2, effect, oxytocic drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins;

Output: <Cholestyramine, mechanism, fat soluble vitamins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin/Phenobarbital: The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism.

Output: <phenytoin, mechanism, calcitriol>, <phenobarbital, mechanism, calcitriol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia.

Output: <thiazides, effect, vitamin D>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias.

Output: <Vitamin D, advise, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D.

Output: <Ketoconazole, mechanism, vitamin D>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.

Output: <vitamin D analogues, mechanism, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.

Output: <Magnesium, advise, vitamin D>, <antacids, advise, vitamin D>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: May interact with the following: cholestyramine, colestipol (use with thiazide diuretics may prevent the diuretic from working properly;

Output: <cholestyramine, effect, thiazide diuretics>, <colestipol, effect, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other CNS depressant drugs (e.g. barbiturates, tranquilizers, opioids and general anesthetics) have additive or potentiating effects with INAPSINE.

Output: <CNS depressant drugs, effect, INAPSINE>, <barbiturates, effect, INAPSINE>, <tranquilizers, effect, INAPSINE>, <opioids, effect, INAPSINE>, <anesthetics, effect, INAPSINE>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Following the administration of INAPSINE, the dose of other CNS depressant drugs should be reduced.

Output: <INAPSINE, advise, CNS depressant drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously because both drugs are direct cardiac stimulants and their combined effects may induce serious arrhythmias.

Output: <Isoproterenol hydrochloride, advise, epinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ISUPREL should be used with caution, if at all, when potent inhalational anesthetics such as halothane are employed because of potential to sensitize the myocardium to effects of sympathomimetic amines.

Output: <ISUPREL, advise, anesthetics>, <ISUPREL, advise, halothane>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The effectiveness of progestin-only pills is reduced by hepatic enzyme-inducing drugs such as the anticonvulsants phenytoin, carbamazepine, and barbiturates, and the antituberculosis drug rifampin.

Output: <progestin, effect, phenytoin>, <progestin, effect, carbamazepine>, <progestin, effect, barbiturates>, <progestin, effect, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of FACTIVE and calcium carbonate, cimetidine, omeprazole, or an estrogen/progesterone oral contraceptive produced minor changes in the pharmacokinetics of gemifloxacin, which were considered to be without clinical significance.

Output: <FACTIVE, mechanism, calcium carbonate>, <FACTIVE, mechanism, cimetidine>, <FACTIVE, mechanism, omeprazole>, <FACTIVE, mechanism, estrogen>, <FACTIVE, mechanism, progesterone>, <FACTIVE, mechanism, contraceptive>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of FACTIVE with probenecid resulted in a 45% increase in systemic exposure to gemifloxacin.

Output: <FACTIVE, mechanism, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, because some quinolones have been reported to enhance the anticoagulant effects of warfarin or its derivatives in patients, the prothrombin time or other suitable coagulation test should be closely monitored if a quinolone antimicrobial is administered concomitantly with warfarin or its derivatives.

Output: <quinolones, effect, warfarin>, <quinolone antimicrobial, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The absorption of oral gemifloxacin is significantly reduced by the concomitant administration of an antacid containing aluminum and magnesium.

Output: <gemifloxacin, mechanism, aluminum>, <gemifloxacin, mechanism, magnesium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Magnesium- and/or aluminum-containing antacids, products containing ferrous sulfate (iron), multivitamin preparations containing zinc or other metal cations, or Videx (didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be taken within 3 hours before or 2 hours after FACTIVE.

Output: <Magnesium, advise, FACTIVE>, <aluminum, advise, FACTIVE>, <ferrous sulfate, advise, FACTIVE>, <iron, advise, FACTIVE>, <multivitamin preparations, advise, FACTIVE>, <zinc, advise, FACTIVE>, <Videx, advise, FACTIVE>, <didanosine, advise, FACTIVE>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sucralfate should not be taken within 2 hours of FACTIVE.

Output: <Sucralfate, advise, FACTIVE>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Steroids enhance the renal toxicity of edetate calcium disodium in animals. 7 Edetate calcium disodium interferes with the action of zinc insulin preparations by chelating the zinc. 7

Output: <Steroids, effect, edetate calcium disodium>, <Edetate calcium disodium, mechanism, zinc insulin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: (Concurrent use with thiazide diuretics may enhance the possibility of digitalis toxicity associated with hypokalemia.)

Output: <thiazide diuretics, effect, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: for adult-onset diabetics, dosage adjustment of hypoglycemic medications may be necessary during and after thiazide diuretic therapy;

Output: <hypoglycemic medications, advise, thiazide diuretic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: (In some patients, the steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium sparing, and thiazide diuretics.

Output: <steroidal anti-inflammatory agent, effect, loop diuretics>, <steroidal anti-inflammatory agent, effect, potassium sparing diuretics>, <steroidal anti-inflammatory agent, effect, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, when hydroflumethiazide and nonsteroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.)

Output: <hydroflumethiazide, advise, nonsteroidal anti-inflammatory agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: (Thiazides may decrease arterial responsiveness to norepinephrine.

Output: <Thiazides, effect, norepinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: (Thiazide drugs may increase the responsiveness to tubocurarine.)

Output: <Thiazide drugs, effect, tubocurarine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Experience with co-administration of HMG-CoA reductase inhibitors and Fentanyl in patients is limited,therefore,consideration should be given to temporarily suspending use of HMG-CoA reductase inhibitors in patients receiving Fentanyl.

Output: <HMG-CoA reductase inhibitors, advise, Fentanyl>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetaminophen and methotrexate - L-methionine may decrease hepatic toxicity in those with acetaminophen overdosage or in those taking methotrexate.

Output: <L-methionine, effect, acetaminophen>, <L-methionine, effect, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Gentamicin - Methionine may protect against the ototoxic effects of gentamicin.

Output: <Methionine, effect, gentamicin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although BETAGAN used alone has little or no effect on pupil size, mydriasis resulting from concomitant therapy with BETAGAN and epinephrine may occur.

Output: <BETAGAN, effect, epinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may produce vertigo, syncope or postural hypotension.

Output: <beta-blocker, advise, reserpine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients receiving beta-adrenergic blocking agents along with either oral or intravenous calcium antagonists should be monitored for possible atrioventricular conduction disturbances, left ventricular failure and hypotension.

Output: <beta-adrenergic blocking agents, advise, calcium antagonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant use of beta-adrenergic blocking agents with digitalis and calcium antagonists may have additive effects on prolonging atrioventricular conduction time.

Output: <beta-adrenergic blocking agents, effect, digitalis>, <beta-adrenergic blocking agents, effect, calcium antagonist>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenothiazine-related compounds and beta-adrenergic blocking agents may have additive hypotensite effects due to the inhibition of each other s metabolism.

Output: <Phenothiazine-related compounds, mechanism, beta-adrenergic blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: International Normalized Ratio (INR) elevations and/or bleeding events have been reported in some patients taking warfarin while on IRESSA therapy.

Output: <warfarin, effect, IRESSA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Substances that are potent inhibitors of CYP3A4 activity (eg, ketoconazole and itraconazole) decrease gefitinib metabolism and increase gefitinib plasma concentrations.

Output: <ketoconazole, mechanism, gefitinib>, <ketoconazole, mechanism, gefitinib>, <itraconazole, mechanism, gefitinib>, <itraconazole, mechanism, gefitinib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that cause significant sustained elevation in gastric pH (histamine H2-receptor antagonists such as ranitidine or cimetidine) may reduce plasma concentrations of IRESSA and therefore potentially may reduce efficacy.

Output: <histamine H2-receptor antagonists, mechanism, IRESSA>, <ranitidine, mechanism, IRESSA>, <cimetidine, mechanism, IRESSA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phase II clinical trial data, where IRESSA and vinorelbine have been used concomitantly, indicate that IRESSA may exacerbate the neutropenic effect of vinorelbine.

Output: <IRESSA, effect, vinorelbine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and lorazepam.

Output: <loxapine, effect, lorazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that may alter imatinib plasma concentrations Drugs that may increase imatinib plasma concentrations: Caution is recommended when administering Gleevec with inhibitors of the CYP3A4 family (e.g., ketoconazole, itraconazole, erythromycin, clarithromycin).

Output: <Gleevec, advise, ketoconazole>, <Gleevec, advise, itraconazole>, <Gleevec, advise, erythromycin>, <Gleevec, advise, clarithromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There is a significant increase in exposure to imatinib when Gleevec is coadministered with ketoconazole (CYP3A4 inhibitor).

Output: <Gleevec, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pretreatment of healthy volunteers with multiple doses of rifampin followed by a single dose of Gleevec, increased Gleevec oral-dose clearance by 3.8-fold, which significantly (p 0.05) decreased mean cmax and AUC(0-8).

Output: <rifampin, mechanism, Gleevec>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that may have their plasma concentration altered by Gleevec Gleevec increases the mean cmax and AUC of simvastatin (CYP3A4 substrate) 2- and 3.5-fold, respectively, suggesting an inhibition of the CYP3A4 by Gleevec.

Output: <Gleevec, mechanism, simvastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Particular caution is recommended when administering Gleevec with CYP3A4 substrates that have a narrow therapeutic window (e.g., cyclosporine or pimozide).

Output: <Gleevec, advise, cyclosporine>, <Gleevec, advise, pimozide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Gleevec will increase plasmaconcentration of other CYP3A4 metabolized drugs (e.g., triazolo-benzodiazepines, dihydropyridine calcium channel blockers, certain HMG-CoA reductase inhibitors, etc.).

Output: <Gleevec, mechanism, benzodiazepines>, <Gleevec, mechanism, dihydropyridine calcium channel blockers>, <Gleevec, mechanism, HMG-CoA reductase inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Systemic exposure to acetaminophen is expected to be increased when coadministered with Gleevec.

Output: <acetaminophen, mechanism, Gleevec>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A possible drug interaction of FOSCAVIR and intravenous pentamidine has been described.

Output: <FOSCAVIR, int, pentamidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant treatment of four patients in the United Kingdom with FOSCAVIR and intravenous pentamidine may have caused hypocalcemia;

Output: <FOSCAVIR, effect, pentamidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because of foscarnets tendency to cause renal impairment, the use of FOSCAVIR should be avoided in combination with potentially nephrotoxic drugs such as aminoglycosides, amphotericin B and intravenous pentamidine unless the potential benefits outweigh the risks to the patient.

Output: <FOSCAVIR, advise, aminoglycosides>, <FOSCAVIR, advise, amphotericin B>, <FOSCAVIR, advise, pentamidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and naratriptan within 24 hours is contraindicated.

Output: <ergotamine, advise, naratriptan>, <ergot-type medications, advise, naratriptan>, <dihydroergotamine, advise, naratriptan>, <methysergide, advise, naratriptan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because their vasospastic effects may be additive, coadministration of naratriptan and other 5-HT1 agonists within 24 hours of each other is not recommended.

Output: <naratriptan, advise, 5-HT1 agonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If concomitant treatment with naratriptan and an SSRI is clinically warranted, appropriate observation of the patient is advised.

Output: <naratriptan, advise, SSRI>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine at 400 mg BID (the usual prescription dose) co-administered with TIKOSYN (500 mcg BID) for 7 days has been shown to increase dofetilide plasma levels by 58%.

Output: <Cimetidine, mechanism, TIKOSYN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine at doses of 100 mg BID (OTC dose) resulted in a 13% increase in dofetilide plasma levels (500 mcg single dose).

Output: <Cimetidine, mechanism, dofetilide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If a patient requires TIKOSYN and anti-ulcer therapy, it is suggested that omeprazole, ranitidine, or antacids (aluminum and magnesium hydroxides) be used as alternatives to cimetidine, as these agents have no effect on the pharmacokinetic profile of TIKOSYN.

Output: <TIKOSYN, advise, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of TIKOSYN with verapamil resulted in increases in dofetilide peak plasma levels of 42%, although overall exposure to dofetilide was not significantly increased.

Output: <TIKOSYN, mechanism, verapamil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In an analysis of the supraventricular arrhythmia and DIAMOND patient populations, the concomitant administration of verapamil with dofetilide was associated with a higher occurrence of torsade de pointes.

Output: <verapamil, effect, dofetilide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole at 400 mg daily (the maximum approved prescription dose) co-administered with TIKOSYN (500 mcg BID) for 7 days has been shown to increase dofetilide Cmax by 53% in males and 97% in females, and AUC by 41% in males and 69% in females.

Output: <Ketoconazole, mechanism, TIKOSYN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients receiving HCTZ alone, dofetilide AUC increased by 27% and Cmax by 21%.

Output: <HCTZ, mechanism, dofetilide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition, drugs that are actively secreted via this route (e.g., triamterene, metformin and amiloride) should be co-administered with care as they might increase dofetilide levels.

Output: <triamterene, advise, dofetilide>, <metformin, advise, dofetilide>, <amiloride, advise, dofetilide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Inhibitors of this isoenzyme (e.g., macrolide antibiotics, azole antifungal agents, protease inhibitors, serotonin reuptake inhibitors, amiodarone, cannabinoids, diltiazem, grapefruit juice, nefazadone, norfloxacin, quinine, zafirlukast) should be cautiously coadministered with TIKOSYN as they can potentially increase dofetilide levels.

Output: <macrolide antibiotics, advise, TIKOSYN>, <azole antifungal agents, advise, TIKOSYN>, <protease inhibitors, advise, TIKOSYN>, <serotonin reuptake inhibitors, advise, TIKOSYN>, <amiodarone, advise, TIKOSYN>, <cannabinoids, advise, TIKOSYN>, <diltiazem, advise, TIKOSYN>, <nefazadone, advise, TIKOSYN>, <norfloxacin, advise, TIKOSYN>, <quinine, advise, TIKOSYN>, <zafirlukast, advise, TIKOSYN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients, the concomitant administration of digoxin with dofetilide was associated with a higher occurrence of torsade de pointes.

Output: <digoxin, effect, dofetilide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The mean clearances of dofetilide were 16% and 15% lower in patients on thiazide diuretics and inhibitors of tubular organic cation transport, respectively.

Output: <dofetilide, mechanism, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Intravenous ranitidine was shown to double the bioavailability of oral alendronate.

Output: <ranitidine, mechanism, alendronate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Products containing calcium and other multivalent cations likely will interfere with absorption of alendronate.

Output: <calcium, mechanism, alendronate>, <multivalent cations, mechanism, alendronate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Clinical studies with celecoxib have identified potentially significant interactions with fluconazole and lithium.

Output: <celecoxib, int, fluconazole>, <celecoxib, int, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Experience with nonsteroidal anti-inflammatory drugs (NSAIDs) suggests the potential for interactions with furosemide and ACE inhibitors.

Output: <nonsteroidal anti-inflammatory drugs, int, furosemide>, <nonsteroidal anti-inflammatory drugs, int, ACE inhibitors>, <NSAIDs, int, furosemide>, <NSAIDs, int, ACE inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors.

Output: <NSAIDs, effect, Angiotensin Converting Enzyme (ACE) inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This interaction should be given consideration in patients taking CELEBREX concomitantly with ACE-inhibitors.

Output: <CELEBREX, advise, ACE-inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide: Clinical studies, as well as post marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.

Output: <NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: CELEBREX can be used with low dose aspirin.

Output: <CELEBREX, advise, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, concomitant administration of aspirin with CELEBREX may result in an increased rate of GI ulceration or other complications, compared to use of CELEBREX alone.

Output: <aspirin, effect, CELEBREX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Fluconazole: Concomitant administration of fluconazole at 200 mg QD resulted in a two-fold increase in celecoxib plasma concentration.

Output: <fluconazole, mechanism, celecoxib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This increase is due to the inhibition of celecoxib metabolism via P450 2C9 by fluconazole (see CLINICAL PHARMACOLOGY - Pharmacokinetics: Metabolism).

Output: <celecoxib, mechanism, fluconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: CELEBREX should be introduced at the lowest recommended dose in patients receiving fluconazole.

Output: <CELEBREX, advise, fluconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: In a study conducted in healthy subjects, mean steady-state lithium plasma levels increased approximately 17% in subjects receiving lithium 450 mg BID with CELEBREX 200 mg BID as compared to subjects receiving lithium alone.

Output: <lithium, mechanism, CELEBREX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients on lithium treatment should be closely monitored when CELEBREX is introduced or withdrawn.

Output: <lithium, advise, CELEBREX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, caution should be used when administering CELEBREX with warfarin since these patients are at increased risk of bleeding complications.

Output: <CELEBREX, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Medroxyprogesterone Acetate - L-histidine was observed to enhance (in tissue culture) the effect of medroxyprogesterone acetate in reducing the number of human breast cancer cells that were in the S phase.

Output: <L-histidine, effect, medroxyprogesterone acetate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: H1 and H2 Blockers - Although not reported, L-histidine, via its metabolism to histamine, might decrease the efficacy of H1 and H2 blockers.

Output: <L-histidine, effect, H1 blockers>, <L-histidine, effect, H2 blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving systemic cyclosporine concomitantly.

Output: <quinolones, mechanism, theophylline>, <quinolones, mechanism, caffeine>, <quinolones, effect, warfarin>, <quinolones, effect, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Erythromycin (500 mg t.i.d) produced a 4-fold increase in vardenafil AUC and a 3-fold increase in Cmax when co-administered with Vardenafil 5 mg in healthy volunteers.

Output: <Erythromycin, mechanism, vardenafil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended not to exceed a single 5 mg dose of Vardenafil in a 24-hour period when used in combination with erythromycin.

Output: <Vardenafil, advise, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole (200 mg once daily) produced a 10-fold increase in vardenafil AUC and a 4-fold increase in Cmax when co-administered with Vardenafil (5 mg) in healthy volunteers.

Output: <Ketoconazole, mechanism, vardenafil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A 5-mg Vardenafil dose should not be exceeded when used in combination with 200 mg once daily ketoconazole.

Output: <Vardenafil, advise, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since higher doses of ketoconazole (400 mg daily) may result in higher increases in Cmax and AUC, a single 2.5 mg dose of Vardenafil should not be exceeded in a 24-hour period when used in combination with ketoconazole 400 mg daily.

Output: <Vardenafil, advise, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: HIV Protease Inhibitors: Indinavir (800 mg t.i.d.) co-administered with Vardenafil 10 mg resulted in a 16-fold increase in vardenafil AUC, a 7-fold increase in vardenafil Cmax and a 2-fold increase in vardenafil half-life.

Output: <Indinavir, mechanism, Vardenafil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended not to exceed a single 2.5 mg Vardenafil dose in a 24-hour period when used in combination with indinavir.

Output: <Vardenafil, advise, indinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ritonavir (600 mg b.i.d.) co-administered with Vardenafil 5 mg resulted in a 49-fold increase in vardenafil AUC and a 13-fold increase in vardenafil Cmax.

Output: <Ritonavir, mechanism, Vardenafil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The interaction is a consequence of blocking hepatic metabolism of vardenafil by ritonavir, a highly potent CYP3A4 inhibitor, which also inhibits CYP2C9.

Output: <vardenafil, mechanism, ritonavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ritonavir significantly prolonged the half-life of vardenafil to 26 hours.

Output: <Ritonavir, mechanism, vardenafil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Consequently, it is recommended not to exceed a single 2.5 mg Vardenafil dose in a 72-hour period when used in combination with ritonavir.

Output: <Vardenafil, advise, ritonavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In vivo studies: Nitrates: The blood pressure lowering effects of sublingual nitrates (0.4 mg) taken 1 and 4 hours after vardenafil and increases in heart rate when taken at 1, 4 and 8 hours were potentiated by a 20 mg dose of Vardenafil in healthy middle-aged subjects.

Output: <nitrates, mechanism, vardenafil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Potentiation of the hypotensive effects of nitrates for patients with ischemic heart disease has not been evaluated, and concomitant use of Vardenafil and nitrates is contraindicated.

Output: <Vardenafil, advise, nitrates>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In these patients whose hypertension was controlled with nifedipine, Vardenafil 20 mg produced mean additional supine systolic/diastolic blood pressure reductions of 6/5 mm Hg compared to placebo.

Output: <nifedipine, effect, Vardenafil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Alpha-blockers: When Vardenafil 10 or 20 mg was given to healthy volunteers either simultaneously or 6 hours after a 10 mg dose of terazosin, significant hypotension developed in a substantial number of subjects.

Output: <Vardenafil, effect, terazosin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: With simultaneous dosing of Vardenafil 10 mg and terazosin 10 mg, 6 of 8 subjects experienced a standing systolic blood pressure of less than 85 mm Hg.

Output: <Vardenafil, effect, terazosin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: With simultaneous dosing of Vardenafil 20 mg and terazosin 10 mg, 2 of 9 subjects experienced a standing systolic blood pressure of less than 85 mm Hg.

Output: <Vardenafil, effect, terazosin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When Vardenafil dosing was separated from terazosin 10 mg by 6 hours, 7 of 28 subjects who received 20 mg of Vardenafil experienced a decrease in standing systolic blood pressure below 85 mm Hg.

Output: <Vardenafil, effect, terazosin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a similar study with tamsulosin in healthy volunteers, 1 of 24 subjects dosed with Vardenafil 20 mg and tamsulosin 0.4 mg separated by 6 hours experienced a standing systolic blood pressure below 85 mm Hg.

Output: <Vardenafil, effect, tamsulosin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Two of 16 subjects dosed simultaneously with Vardenafil 10 mg and tamsulosin 0.4 mg experienced a standing systolic blood pressure below 85 mm Hg.

Output: <Vardenafil, effect, tamsulosin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Based on these data, Vardenafil should not be used in patients on alpha-blocker therapy.

Output: <Vardenafil, advise, alpha-blocker>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ritonavir and indinavir: Upon concomitant administration of 5 mg of Vardenafil with 600 mg BID ritonavir, the Cmax and AUC of ritonavir were reduced by approximately 20%.

Output: <Vardenafil, mechanism, ritonavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Upon administration of 10 mg of Vardenafil with 800 mg TID indinavir, the Cmax and AUC of indinavir were reduced by 40% and 30%, respectively.

Output: <Vardenafil, mechanism, indinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In vitro studies have shown that the metabolism of docetaxel may be modified by the concomitant administration of compounds that induce, inhibit, or are metabolized by cytochrome P450 3A4, such as cyclosporine, terfenadine, ketoconazole, erythromycin, and troleandomycin.

Output: <docetaxel, mechanism, cyclosporine>, <docetaxel, mechanism, terfenadine>, <docetaxel, mechanism, ketoconazole>, <docetaxel, mechanism, erythromycin>, <docetaxel, mechanism, troleandomycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid: As with other b-lactam antibiotics, renal excretion of loracarbef is inhibited by probenecid and resulted in an approximate 80% increase in the AUC for loracarbef.

Output: <b-lactam antibiotics, mechanism, probenecid>, <loracarbef, mechanism, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients stabilized on oral anticoagulants who are found to require thyroid replacement therapy should be watched very closely when thyroid is started.

Output: <anticoagulants, advise, thyroid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cholestyramine: Cholestyramine binds both T4 and T3 in the intestine, thus impairing absorption of these thyroid hormones.

Output: <Cholestyramine, mechanism, T4>, <Cholestyramine, mechanism, T3>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, 4 to 5 hours should elapse between administration of cholestyramine and thyroid hormones.

Output: <cholestyramine, advise, thyroid hormones>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a patient with a nonfunctioning thyroid gland who is receiving thyroid replacement therapy, free levothyroxine may be decreased when estrogens are started thus increasing thyroid requirements.

Output: <levothyroxine, mechanism, estrogens>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, patients without a functioning thyroid gland who are on thyroid replacement therapy may need to increase their thyroid dose if estrogens or estrogen-containing oral contraceptives are given.

Output: <thyroid, advise, estrogens>, <thyroid, advise, contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tricyclic Antidepressants: Use of thyroid products with imipramine and other tricyclic antidepressants may increase receptor sensitivity and enhance antidepressant activity transient cardiac arrhythmias have been observed.

Output: <thyroid products, effect, imipramine>, <thyroid products, effect, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digitalis: Thyroid preparations may potentiate the toxic effects of digitalis.

Output: <Thyroid preparations, effect, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketamine: When administered to patients on a thyroid preparation, this parenteral anesthetic may cause hypertension and tachycardia.

Output: <thyroid preparation, effect, anesthetic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Vasopressors: Thyroxine increases the adrenergic effect of catecholamines such as epinephrine and norepinephrine.

Output: <Thyroxine, effect, epinephrine>, <Thyroxine, effect, norepinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Results of preliminary studies in humans and rats suggest that nonabsorbable antacids given concurrently with lactulose may inhibit the desired lactulose-induced drop in colonic pH.

Output: <antacids, mechanism, lactulose>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity.

Output: <FLUDARA, advise, pentostatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anafranil should not be used with MAO inhibitors.

Output: <Anafranil, advise, MAO inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Close supervision and careful adjustment of dosage are required when Anafranil is administered with anticholinergic or sympathomimetic drugs.

Output: <Anafranil, advise, anticholinergic>, <Anafranil, advise, sympathomimetic drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Several tricyclic antidepressants have been reported to block the pharmacologic effects of guanethidine, clonidine, or similar agents, and such an effect may be anticipated with CMI because of its structural similarity to other tricyclic antidepressants.

Output: <tricyclic antidepressants, effect, guanethidine>, <tricyclic antidepressants, effect, clonidine>, <tricyclic antidepressants, effect, CMI>, <tricyclic antidepressants, effect, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The plasma concentration of CMI has been reported to be increased by the concomitant administration of haloperidol;

Output: <CMI, mechanism, haloperidol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: plasma levels of several closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of methylphenidate or hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and such an effect may be anticipated with CMI as well.

Output: <tricyclic antidepressants, mechanism, methylphenidate>, <tricyclic antidepressants, mechanism, cimetidine>, <tricyclic antidepressants, mechanism, fluoxetine>, <tricyclic antidepressants, mechanism, barbiturates>, <tricyclic antidepressants, mechanism, phenytoin>, <methylphenidate, mechanism, CMI>, <cimetidine, mechanism, CMI>, <fluoxetine, mechanism, CMI>, <barbiturates, mechanism, CMI>, <phenytoin, mechanism, CMI>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of CMI has been reported to increase the plasma levels of phenobarbital, if given concomitantly.

Output: <CMI, mechanism, phenobarbital>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Fluvoxamine has also been shown to inhibit P450 1A2, an isoform also involved in TCAmetabolism.

Output: <Fluvoxamine, mechanism, TCA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The extent to which SSRI-TCAinteractions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.

Output: <SSRI, int, TCA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nevertheless, caution is indicated in the co-administration of TCAs with any of the SSRIs and also in switching from one class to the other.

Output: <TCAs, advise, SSRIs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Of particular importance, sufficient time must elapse before initiating TCAtreatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary).

Output: <TCA, advise, fluoxetine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because Anafranil is highly bound to serum protein, the administration of Anafranil to patients taking other drugs that are highly bound to protein (e.g., warfarin, digoxin) may cause an increase in plasma concentrations of these drugs, potentially resulting in adverse effects.

Output: <Anafranil, mechanism, warfarin>, <Anafranil, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digitalis toxicity may be aggravated by the initial release of norepinephrine caused by Bretylium Tosylate Injection.

Output: <Digitalis, effect, Bretylium Tosylate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The pressor effects of catecholamines such as dopamine or norepinephrine are enhanced by Bretylium Tosylate.

Output: <catecholamines, effect, Bretylium Tosylate>, <dopamine, effect, Bretylium Tosylate>, <norepinephrine, effect, Bretylium Tosylate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Isoflurane potentiates the muscle relaxant effect of all muscle relaxants, most notably nondepolarizing muscle relaxants, and MAC (minimum alveolar concentration) is reduced by concomitant administration of N 2O.

Output: <Isoflurane, effect, muscle relaxants>, <Isoflurane, effect, nondepolarizing muscle relaxants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Barbiturates may decrease the effectiveness of oral contraceptives, certain antibiotics, quinidine, theophylline, corticosteroids, anticoagulants, and beta blockers.

Output: <Barbiturates, effect, contraceptives>, <Barbiturates, effect, antibiotics>, <Barbiturates, effect, quinidine>, <Barbiturates, effect, theophylline>, <Barbiturates, effect, corticosteroids>, <Barbiturates, effect, anticoagulants>, <Barbiturates, effect, beta blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients who have been treated with MAO inhibitors within two to three weeks prior to the administration of dopamine HCl should receive initial doses of dopamine HCl no greater than one-tenth (1/10) of the usual dose.

Output: <MAO inhibitors, advise, dopamine HCl>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent administration of low-dose dopamine HCl and diuretic agents may produce an additive or potentiating effect on urine flow.

Output: <dopamine HCl, effect, diuretic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cardiac effects of dopamine are antagonized by beta-adrenergic blocking agents, such as propranolol and metoprolol.

Output: <dopamine, effect, beta-adrenergic blocking agents>, <dopamine, effect, propranolol>, <dopamine, effect, metoprolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The peripheral vasoconstriction caused by high doses of dopamine HCl is antagonized by alpha-adrenergic blocking agents.

Output: <dopamine HCl, effect, alpha-adrenergic blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Butyrophenones (such as haloperidol) and phenothiazines can suppress the dopaminergic renal and mesenteric vasodilation induced with low dose dopamine infusion.

Output: <Butyrophenones, effect, dopamine>, <haloperidol, effect, dopamine>, <phenothiazines, effect, dopamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclopropane or halogenated hydrocarbon anesthetics increase cardiac autonomic irritability and may sensitize the myocardium to the action of certain intravenously administered catecholamines, such as dopamine.

Output: <Cyclopropane, effect, catecholamines>, <Cyclopropane, effect, dopamine>, <halogenated hydrocarbon anesthetics, effect, catecholamines>, <halogenated hydrocarbon anesthetics, effect, dopamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, EXTREME CAUTION should be exercised when administering dopamine HCl to patients receiving cyclopropane or halogenated hydrocarbon anesthetics.

Output: <dopamine HCl, advise, cyclopropane>, <dopamine HCl, advise, halogenated hydrocarbon anesthetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It has been reported that results of studies in animals indicate that dopamine-induced ventricular arrhythmias during anesthesia can be reversed by propranolol.

Output: <dopamine, effect, propranolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant use of vasopressors, vasoconstricting agents (such as ergonovine) and some oxytocic drugs may result in severe hypertension.

Output: <vasopressor, effect, oxytocic drugs>, <ergonovine, effect, oxytocic drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of phenytoin to patients receiving dopamine HCl has been reported to lead to hypotension and bradycardia.

Output: <phenytoin, effect, dopamine HCl>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is suggested that in patients receiving dopamine HCl, alternatives to phenytoin should be used if anticonvulsant therapy is needed.

Output: <dopamine HCl, advise, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The results of a study of coadministration of ethambutol (50 mg/kg) with an aluminum hydroxide containing antacid to 13 patients with tuberculosis showed a reduction of mean serum concentrations and urinary excretion of ethambutol of approximately 20% and 13%, respectively, suggesting that the oral absorption of ethambutol may be reduced by these antacid products.

Output: <ethambutol, mechanism, aluminum hydroxide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended to avoid concurrent administration of ethambutol with aluminum hydroxide containing antacids for at least 4 hours following ethambutol administration.

Output: <ethambutol, advise, aluminum hydroxide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drug Interactions: The central anticholinergic syndrome can occur when anticholinergic agents such as AKINETON are administered concomitantly with drugs that have secondary anticholinergic actions, e.g., certain narcotic analgesics such as meperidine, the phenothiazines and other antipsychotics, tricyclic antidepressants, certain antiarrhythmics such as the quinidine salts, and antihistamines.

Output: <anticholinergic, effect, narcotic analgesics>, <anticholinergic, effect, meperidine>, <anticholinergic, effect, phenothiazines>, <anticholinergic, effect, antipsychotics>, <anticholinergic, effect, tricyclic antidepressants>, <anticholinergic, effect, antiarrhythmics>, <anticholinergic, effect, quinidine>, <anticholinergic, effect, antihistamines>, <AKINETON, effect, narcotic analgesics>, <AKINETON, effect, meperidine>, <AKINETON, effect, phenothiazines>, <AKINETON, effect, antipsychotics>, <AKINETON, effect, tricyclic antidepressants>, <AKINETON, effect, antiarrhythmics>, <AKINETON, effect, quinidine>, <AKINETON, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant use of transdermal fentanyl with ritonavir or other potent 3A4 inhibitors such as ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, and nefazadone may result in an increase in fentanyl plasma concentrations.

Output: <fentanyl, mechanism, ritonavir>, <fentanyl, mechanism, ketoconazole>, <fentanyl, mechanism, itraconazole>, <fentanyl, mechanism, troleandomycin>, <fentanyl, mechanism, clarithromycin>, <fentanyl, mechanism, nelfinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant use of other CYP3A4 inhibitors such as diltiazem and erythromycin with transdermal fentanyl may also result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause serious respiratory depression.

Output: <diltiazem, mechanism, fentanyl>, <erythromycin, mechanism, fentanyl>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Central Nervous System Depressants: The concomitant use of DURAGESIC  (fentanyl transdermal system) with other central nervous system depressants, including but not limited to other opioids, sedatives, hypnotics, tranquilizers (e.g., benzodiazepines), general anesthetics, phenothiazines, skeletal muscle relaxants, and alcohol, may cause respiratory depression, hypotension, and profound sedation, or potentially result in coma or death.

Output: <DURAGESIC, effect, central nervous system depressants>, <DURAGESIC, effect, opioids>, <DURAGESIC, effect, sedatives>, <DURAGESIC, effect, hypnotics>, <DURAGESIC, effect, tranquilizers>, <DURAGESIC, effect, benzodiazepines>, <DURAGESIC, effect, anesthetics>, <DURAGESIC, effect, phenothiazines>, <DURAGESIC, effect, skeletal muscle relaxants>, <DURAGESIC, effect, alcohol>, <fentanyl, effect, central nervous system depressants>, <fentanyl, effect, opioids>, <fentanyl, effect, sedatives>, <fentanyl, effect, hypnotics>, <fentanyl, effect, tranquilizers>, <fentanyl, effect, benzodiazepines>, <fentanyl, effect, anesthetics>, <fentanyl, effect, phenothiazines>, <fentanyl, effect, skeletal muscle relaxants>, <fentanyl, effect, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: MAO Inhibitors: DURAGESIC  is not recommended for use in patients who have received MAOI within 14 days because severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics

Output: <DURAGESIC, advise, MAOI>, <MAO inhibitors, advise, opioid analgesics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In vitro studies have shown CASODEX can displace coumarin anticoagulants, such as warfarin, from their protein-binding sites.

Output: <CASODEX, mechanism, coumarin anticoagulant>, <CASODEX, mechanism, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended that if CASODEX is started in patients already receiving coumarin anticoagulants, prothrombin times should be closely monitored and adjustment of the anticoagulant dose may be necessary.

Output: <CASODEX, advise, coumarin anticoagulants>, <CASODEX, advise, anticoagulant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors, tricyclic antidepressants or phenothiazines may produce severe, prolonged hypotension or hypertension.

Output: <anesthetic solutions, effect, tricyclic antidepressants>, <anesthetic solutions, effect, phenothiazines>, <epinephrine, effect, monoamine oxidase inhibitors>, <epinephrine, effect, tricyclic antidepressants>, <epinephrine, effect, phenothiazines>, <norepinephrine, effect, monoamine oxidase inhibitors>, <norepinephrine, effect, tricyclic antidepressants>, <norepinephrine, effect, phenothiazines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent administration of vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents.

Output: <vasopressor drugs, effect, ergot-type oxytocic drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, chloroprocaine should not be used in any condition in which a sulfonamide drug is being employed.

Output: <chloroprocaine, advise, sulfonamide drug>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticholinergic agents may affect gastrointestinal absorption of various drugs, such as slowly dissolving dosage forms of digoxin;

Output: <Anticholinergic agents, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticholinergic drugs may antagonize the effects of the drugs that alter gastrointestinal motility, such as metoclopramide.

Output: <Anticholinergic drugs, mechanism, metoclopramide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because antacids may interfere with the absorption of anticholinergic agents, simultaneous use of these drugs should be avoided.

Output: <antacids, mechanism, anticholinergic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a study in which patients with active RA were treated for up to 24 weeks with concurrent ENBREL  and anakinra therapy, a 7% rate of serious infections was observed, which was higher than that observed with ENBREL  alone (0%).

Output: <ENBREL, effect, anakinra>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Two percent of patients treated concurrently with ENBREL  and anakinra developed neutropenia (ANC   1 x 109/L).

Output: <ENBREL, effect, anakinra>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients in a clinical study who were on established therapy with sulfasalazine, to which ENBREL was added, were noted to develop a mild decrease in mean neutrophil counts in comparison to groups treated with either ENBREL CI or sulfasalazine alone.

Output: <sulfasalazine, effect, ENBREL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be exercised when administering nabumetone with warfarin since interactions have been seen with other NSAIDs.

Output: <nabumetone, advise, warfarin>, <warfarin, int, NSAIDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids (aluminum- or magnesium-containing): Concomitant administration of 300-mg cefdinir capsules with 30 mL Maalox TC suspension reduces the rate (Cmax) and extent (AUC) of absorption by approximately 40%.

Output: <cefdinir, mechanism, Maalox TC>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If antacids are required during OMNICEF therapy, OMNICEF should be taken at least 2 hours before or after the antacid.

Output: <OMNICEF, advise, antacid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid: As with other b-lactam antibiotics, probenecid inhibits the renal excretion of cefdinir, resulting in an approximate doubling in A.C. a 54% increase in peak cefdinir plasma levels, and a 50% prolongation in the apparent elimination half-life.

Output: <b-lactam antibiotics, mechanism, cefdinir>, <probenecid, mechanism, cefdinir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Iron Supplements and Foods Fortified With Iron Concomitant administration of cefdinir with a therapeutic iron supplement containing 60 mg of elemental iron (as FeSO4) or vitamins supplemented with 10 mg of elemental iron reduced extent of absorption by 80% and 31%, respectively.

Output: <cefdinir, mechanism, iron>, <cefdinir, mechanism, iron>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If iron supplements are required during OMNICEF therapy, OMNICEF should be taken at least 2 hours before or after the supplement.

Output: <iron supplements, advise, OMNICEF>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The reddish color is due to the formation of a nonabsorbable complex between cefdinir or its breakdown products and iron in the gastrointestinal tract.

Output: <cefdinir, mechanism, iron>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent use of butorphanol with central nervous system depressants (e.g., alcohol, barbiturates, tranquilizers, and antihistamines) may result in increased central nervous system depressant effects.

Output: <butorphanol, effect, central nervous system depressants>, <butorphanol, effect, alcohol>, <butorphanol, effect, barbiturates>, <butorphanol, effect, tranquilizers>, <butorphanol, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, in another study in healthy volunteers, the pharmacokinetics of butorphanol were significantly altered (29% decrease in AUC and 38% decrease in Cmax) when a 1-mg dose of STADOL NS was administered 1 minute after a 20-mg dose of sumatriptan nasal spray.

Output: <STADOL NS, mechanism, sumatriptan>