Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although there was no effect of Aprepitant on the plasma AUC of R(+) or S(-) warfarin determined on Day 3, there was a 34% decrease in S(-)warfarin (a CYP2C9 substrate) trough concentration accompanied by a 14% decrease in the prothrombin time (reported as International Normalized Ratio or INR) 5 days after completion of dosing with Aprepitant.

Output: <S(-)warfarin, mechanism, Aprepitant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients on chronic warfarin therapy, the prothrombin time (INR) should be closely monitored in the 2-week period, particularly at 7 to 10 days, following initiation of the 3-day regimen of Aprepitant with each chemotherapy cycle.

Output: <warfarin, advise, Aprepitant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tolbutamide: Aprepitant, when given as 125 mg on Day 1 and 80 mg/day on Days 2 and 3, decreased the AUC of tolbutamide (a CYP2C9 substrate) by 23% on Day 4, 28% on Day 8, and 15% on Day 15, when a single dose of tolbutamide 500 mg was admini,stered orally prior to the administration of the 3-day regimen of Aprepitant and on Days 4,8, and 15.

Output: <tolbutamide, mechanism, Aprepitant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oral contraceptives: Aprepitant, when given once daily for 14 days as a 100-mg capsule with an oral contraceptive containing 35 mcg of ethinyl estradiol and 1 mg of norethindrone, decreased the AUC of ethinyl estradiol by 43%, and decreased the AUC of norethindrone by 8%;

Output: <Aprepitant, mechanism, ethinyl estradiol>, <Aprepitant, mechanism, norethindrone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: therefore, the efficacy of oral contraceptives during administration of Aprepitant may be reduced.

Output: <contraceptives, effect, Aprepitant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although a 3-day regimen of Aprepitant given concomitantly with oral contraceptives has not been studied, alternative or back-up methods of contraception should be used.

Output: <Aprepitant, advise, contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Midazolam: Aprepitant increased the AUC of midazolam, a sensitive CYP3A4 substrate, by 2.3-fold on Day 1 and 3.3-fold on Day 5, when a single oral dose of midazolam 2 mg was coadministered on Day 1 and Day 5 of a regimen of Aprepitant 125 mg on Day 1 and 80 mg/day on Days 2 through 5.

Output: <Aprepitant, mechanism, midazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The potential effects of increased plasma concentrations of midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) should be considered when coadministering these agents with Aprepitant.

Output: <midazolam, advise, Aprepitant>, <benzodiazepines, advise, Aprepitant>, <alprazolam, advise, Aprepitant>, <triazolam, advise, Aprepitant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aprepitant increased the AUC of midazolam by 25% on Day 4 and decreased the AUC of midazolam by 19% on Day 8 relative to the dosing of Aprepitant on Days 1 through 3.

Output: <Aprepitant, mechanism, midazolam>, <Aprepitant, mechanism, midazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Consequently, concomitant administration of Aprepitant with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir) should be approached with caution.

Output: <Aprepitant, advise, ketoconazole>, <Aprepitant, advise, itraconazole>, <Aprepitant, advise, nefazodone>, <Aprepitant, advise, troleandomycin>, <Aprepitant, advise, clarithromycin>, <Aprepitant, advise, ritonavir>, <Aprepitant, advise, nelfinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because moderate CYP3A4 inhibitors (e.g., diltiazem) result in 2-fold increase in plasma concentrations of aprepitant, concomitant administration should also be approached with caution.

Output: <diltiazem, advise, aprepitant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: therefore, coadministration of Aprepitant with drugs that strongly induce CYP3A4 activity (e.g., rifampin, carbamazepine, phenytoin) may result in reduced plasma concentrations of aprepitant that may result in decreased efficacy of Aprepitant.

Output: <Aprepitant, mechanism, rifampin>, <Aprepitant, mechanism, phenytoin>, <Aprepitant, mechanism, aprepitant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: When a single 125-mg dose of Aprepitant was administered on Day5 of a 10-day regimen of 400 mg/day of ketoconazole, a strong CYP3A4 inhibitor, the AUC of aprepitant increased approximately 5-fold and the mean terminal half-life of aprepitant increased approximately 3-fold.

Output: <Aprepitant, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rifampin: When a single 375-mg dose of Aprepitant was administered on Day9 of a 14-day regimen of 600 mg/day of rifampin, a strong CYP3A4 inducer, the AUC of aprepitant decreased approximately 11-fold and the mean terminal half-life decreased approximately 3-fold.

Output: <Aprepitant, mechanism, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diltiazem: In patients with mild to moderate hypertension, administration of aprepitant once daily, as a tablet formulation comparable to 230 mg of the capsule formulation, with diltiazem 120 mg 3 times daily for 5 days, resulted in a 2-fold increase of aprepitant AUC and a simultaneous 1.7-fold increase of diltiazem AUC.

Output: <aprepitant, mechanism, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Paroxetine: Coadministration of once daily doses of aprepitant, as a tablet formulation comparable to 85 mg or 170 mg of the capsule formulation, with paroxetine 20 mg once daily, resulted in a decrease in AUC by approximately 25% and Cmax, by approximately 20% of both aprepitant and paroxetine.

Output: <aprepitant, mechanism, paroxetine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

Output: <tetracyclines, advise, anticoagulant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin.

Output: <tetracyclines, advise, penicillin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.

Output: <tetracyclines, mechanism, aluminum>, <tetracyclines, mechanism, calcium>, <tetracyclines, mechanism, magnesium>, <tetracyclines, mechanism, iron>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Absorption of tetracycline is impaired by bismuth subsalicylate.

Output: <tetracycline, mechanism, bismuth subsalicylate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.

Output: <Barbiturates, mechanism, doxycycline>, <carbamazepine, mechanism, doxycycline>, <phenytoin, mechanism, doxycycline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concurrent use of tetracycline and Penthrane (methoxyflurane) has been reported to result in fatal renal toxicity.

Output: <tetracycline, effect, Penthrane>, <tetracycline, effect, methoxyflurane>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent use of tetracycline may render oral contraceptives less effective.

Output: <tetracycline, effect, contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition to bleeding associated with heparin and vitamin K antagonists, drugs that alter platelet function (such as acetylsalicylic acid, dipyridamole and Abciximab) may increase the risk of bleeding if administered prior to, during, or after Activase therapy.

Output: <heparin, effect, Activase>, <vitamin K antagonists, effect, Activase>, <acetylsalicylic acid, int, Activase>, <dipyridamole, effect, Activase>, <Abciximab, effect, Activase>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients receiving other narcotic analgesics, antipsychotics, antianxiety agents, or other CNS depressants (including alcohol) concomitantly with hydrocodone and acetaminophen tablets may exhibit an additive CNS depression.

Output: <narcotic analgesics, effect, hydrocodone>, <antipsychotics, effect, hydrocodone>, <antianxiety agents, effect, hydrocodone>, <CNS depressants, effect, hydrocodone>, <alcohol, effect, hydrocodone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The use of MAO inhibitors or tricyclic antidepressants with hydrocodone preparations may increase the effect of either the antidepressant or hydrocodone.

Output: <MAO inhibitors, effect, hydrocodone>, <tricyclic antidepressants, effect, hydrocodone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concurrent use of anticholinergics with hydrocodone may produce paralytic ileus.

Output: <anticholinergics, effect, hydrocodone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Due to a theoretical risk of a pharmacodynamic interaction, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and FROVA within 24 hours of each other should be avoided (see  a href= frova_od.htm#CI CONTRAINDICATIONS).

Output: <ergotamine, advise, FROVA>, <ergot-type medications, advise, FROVA>, <dihydroergotamine, advise, FROVA>, <methysergide, advise, FROVA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Selective serotonin reuptake inhibitors (SSRIs) (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline) have been reported, rarely, to cause weakness, hyperreflexia, and incoordination when coadministered with 5-HT1 agonists.

Output: <Selective serotonin reuptake inhibitors, effect, 5-HT1 agonists>, <SSRIs, effect, 5-HT1 agonists>, <fluoxetine, effect, 5-HT1 agonists>, <fluvoxamine, effect, 5-HT1 agonists>, <paroxetine, effect, 5-HT1 agonists>, <sertraline, effect, 5-HT1 agonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If concomitant treatment with frovatriptan and an SSRI is clinically warranted, appropriate observation of the patient is advised.

Output: <frovatriptan, advise, SSRI>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines.

Output: <decongestants, advise, tricyclic antidepressants>, <anesthetics, advise, tricyclic antidepressants>, <sympathomimetic amine, advise, tricyclic antidepressants>, <epinephrine, advise, tricyclic antidepressants>, <norepinephrine, advise, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Imipramine hydrochloride may potentiate the effects of CNS depressant drugs.

Output: <Imipramine hydrochloride, effect, CNS depressant drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary.

Output: <imipramine, mechanism, cimetidine>, <imipramine, mechanism, fluoxetine>, <imipramine, mechanism, barbiturates>, <imipramine, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved.

Output: <SSRI, int, TCA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oral neomycin inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil.

Output: <neomycin, mechanism, penicillin V>, <neomycin, mechanism, vitamin B-12>, <neomycin, mechanism, methotrexate>, <neomycin, mechanism, 5-fluorouracil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oral neomycin sulfate may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability.

Output: <neomycin sulfate, effect, coumarin>, <neomycin sulfate, effect, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids and kaolin: Antacids and kaolin can reduce absorption of chloroquine;

Output: <Antacids, mechanism, chloroquine>, <kaolin, mechanism, chloroquine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine: Cimetidine can inhibit the metabolism of chloroquine, increasing its plasma level.

Output: <Cimetidine, mechanism, chloroquine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ampicillin: In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin.

Output: <chloroquine, mechanism, ampicillin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporin: After introduction of chloroquine (oral form), a sudden increase in serum cyclosporin level has been reported.

Output: <chloroquine, mechanism, cyclosporin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The coadministration of aspirin decreases the biologic half-life of fenoprofen because of an increase in metabolic clearance that results in a greater amount of hydroxylated fenoprofen in the urine.

Output: <aspirin, mechanism, fenoprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although the mechanism of interaction between fenoprofen and aspirin is not totally known, enzyme induction and displacement of fenoprofen from plasma albumin binding sites are possibilities.

Output: <fenoprofen, mechanism, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because Nalfon has not been shown to produce any additional effect beyond that obtained with aspirin alone and because aspirin increases the rate of excretion of Nalfon, the concomitant use of Nalfon and salicylates is not recommended.

Output: <aspirin, mechanism, Nalfon>, <Nalfon, advise, salicylates>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chronic administration of phenobarbital, a known enzyme inducer, may be associated with a decrease in the plasma half-life of fenoprofen.

Output: <phenobarbital, mechanism, fenoprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When phenobarbital is added to or withdrawn from treatment, dosage adjustment of Nalfon may be required.

Output: <phenobarbital, advise, Nalfon>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients receiving coumarin-type anticoagulants, the addition of Nalfon to therapy could prolong the prothrombin time.

Output: <coumarin-type anticoagulants, effect, Nalfon>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients treated with Nalfon may be resistant to the effects of loop diuretics.

Output: <Nalfon, effect, loop diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients receiving Nalfon and a steroid concomitantly, any reduction in steroid dosage should be gradual in order to avoid the possible complications of sudden steroid withdrawal.

Output: <Nalfon, advise, steroid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: WelChol  decreased the Cmax and AUC of sustained-release verapamil (Calan SR ) by approximately 31% and 11%, respectively.

Output: <WelChol, mechanism, verapamil>, <WelChol, mechanism, Calan SR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: DIAMOX modifies phenytoin metabolism with increased serum levels of phenytoin.

Output: <DIAMOX, mechanism, phenytoin>, <DIAMOX, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect.

Output: <DIAMOX, mechanism, primidone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone.

Output: <DIAMOX, advise, primidone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetazolamide may increase the effects of other folic acid antagonists.

Output: <Acetazolamide, effect, folic acid antagonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect.

Output: <Acetazolamide, mechanism, amphetamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetazolamide reduces urinary excretion of quinidine and may enhance its effect.

Output: <Acetazolamide, mechanism, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetazolamide may prevent the urinary antiseptic effect of methenamine.

Output: <Acetazolamide, effect, methenamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetazolamide increases lithium excretion and the lithium may be decreased.

Output: <Acetazolamide, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetazolamide and sodium bicarbonate used concurrently increases the risk of renal calculus formation.

Output: <Acetazolamide, effect, sodium bicarbonate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetazolamide may elevate cyclosporine levels.

Output: <Acetazolamide, mechanism, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since PLETAL is extensively metabolized by cytochrome P-450 isoenzymes, caution should be exercised when PLETAL is coadministered with inhibitors of C.P.A. such as ketoconazole and erythromycin or inhibitors of CYP2C19 such as omeprazole.

Output: <PLETAL, advise, ketoconazole>, <PLETAL, advise, erythromycin>, <PLETAL, advise, omeprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pharmacokinetic studies have demonstrated that omeprazole and erythromycin significantly increased the systemic exposure of cilostazol and/or its major metabolites.

Output: <omeprazole, mechanism, cilostazol>, <erythromycin, mechanism, cilostazol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Population pharmacokinetic studies showed higher concentrations of cilostazol among patients concurrently treated with diltiazem, an inhibitor of C.P.A..

Output: <cilostazol, mechanism, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Animal experience indicates that clorazepate dipotassium prolongs the sleeping time after hexobarbital or after ethyl alcohol, increases the inhibitory effects of chlorpromazine, but does not exhibit monoamine oxidase inhibition.

Output: <clorazepate dipotassium, effect, hexobarbital>, <clorazepate dipotassium, effect, ethyl alcohol>, <clorazepate dipotassium, effect, chlorpromazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The actions of the benzodiazepines may be potentiated by barbiturates, narcotics, phenothiazines, monoamine oxidase inhibitors or other antidepressants.

Output: <benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, narcotics>, <benzodiazepines, effect, phenothiazines>, <benzodiazepines, effect, monoamine oxidase inhibitors>, <benzodiazepines, effect, antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phospholine Iodide potentiates other cholinesterase inhibitors such as succinylcholine or organophosphate and carbamate insecticides.

Output: <Phospholine Iodide, effect, cholinesterase inhibitors>, <Phospholine Iodide, effect, succinylcholine>, <Phospholine Iodide, effect, organophosphate insecticide>, <Phospholine Iodide, effect, carbamate insecticide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibiotics or potent diuretics such as furosemide.

Output: <cephalosporins, effect, aminoglycoside antibiotics>, <cephalosporins, effect, diuretics>, <cephalosporins, effect, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chloramphenicol has been shown to be antagonistic to beta-lactam antibiotics, including ceftazidime, based on in vitro studies and time kill curves with enteric gram-negative bacilli.

Output: <Chloramphenicol, effect, beta-lactam antibiotics>, <Chloramphenicol, effect, ceftazidime>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anakinra: Concurrent administration of anakinra (an interleukin-1 antagonist) and another TNF-blocking agent has been associated with an increased risk of serious infections, an increased risk of neutropenia and no additional benefit compared to these medicinal products alone.

Output: <anakinra, effect, TNF-blocking agent>, <interleukin-1 antagonist, effect, TNF-blocking agent>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore the, combination of anakinra with other TNF-blocking agents, including HUMIRA, may also result i n similar toxicities.

Output: <anakinra, effect, TNF-blocking agents>, <anakinra, effect, HUMIRA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concurrent use of two or more drugs with anticholinergic activity--such as an antipsychotic drug (eg, chlorpromazine), an antiparkinsonian drug (eg, trihexyphenidyl), and/or a tricyclic antidepressant (eg, amitriptyline)--commonly results in excessive anticholinergic effects, including dry mouth and associated dental complications, blurred vision, and, in patients exposed to high temperature and humidity, hyperpyrexia.

Output: <antipsychotic drug, effect, antiparkinsonian drug>, <antipsychotic drug, effect, trihexyphenidyl>, <antipsychotic drug, effect, tricyclic antidepressant>, <antipsychotic drug, effect, amitriptyline>, <chlorpromazine, effect, antiparkinsonian drug>, <chlorpromazine, effect, trihexyphenidyl>, <chlorpromazine, effect, tricyclic antidepressant>, <chlorpromazine, effect, amitriptyline>, <antiparkinsonian drug, effect, tricyclic antidepressant>, <antiparkinsonian drug, effect, amitriptyline>, <trihexyphenidyl, effect, tricyclic antidepressant>, <trihexyphenidyl, effect, amitriptyline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Isoflurane, enflurane, and halothane decrease the ED50 of NUROMAX by 30% to 45%.

Output: <Isoflurane, mechanism, NUROMAX>, <enflurane, mechanism, NUROMAX>, <halothane, mechanism, NUROMAX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other drugs which may enhance the neuromuscular blocking action of nondepolarizing agents such as NUROMAX include certain antibiotics (e. g., aminoglycosides, tetracyclines, bacitracin, polymyxins, lincomycin, clindamycin, colistin, and sodium colistimethate), magnesium salts, lithium, local anesthetics, procainamide, and quinidine.

Output: <NUROMAX, effect, antibiotics>, <NUROMAX, effect, aminoglycosides>, <NUROMAX, effect, tetracyclines>, <NUROMAX, effect, bacitracin>, <NUROMAX, effect, polymyxins>, <NUROMAX, effect, lincomycin>, <NUROMAX, effect, clindamycin>, <NUROMAX, effect, colistin>, <NUROMAX, effect, sodium colistimethate>, <NUROMAX, effect, magnesium>, <NUROMAX, effect, lithium>, <NUROMAX, effect, anesthetics>, <NUROMAX, effect, procainamide>, <NUROMAX, effect, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: As with some other nondepolarizing neuromuscular blocking agents, the time of onset of neuromuscular block induced by NUROMAX is lengthened and the duration of block is shortened in patients receiving phenytoin or carbamazepine.

Output: <nondepolarizing neuromuscular blocking agents, effect, phenytoin>, <nondepolarizing neuromuscular blocking agents, effect, carbamazepine>, <NUROMAX, effect, phenytoin>, <NUROMAX, effect, carbamazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Plasma levels of anticonvulsant agents may become subtherapeutic during cisplatin therapy.

Output: <anticonvulsant agents, mechanism, cisplatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: poor metabolizers of debrisoquin: Interactions of carvedilol with strong inhibitors of CYP2D6 (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol .

Output: <quinidine, effect, carvedilol>, <fluoxetine, effect, carvedilol>, <paroxetine, effect, carvedilol>, <propafenone, effect, carvedilol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Catecholamine-depleting Agents: Patients taking both agents with b-blocking properties and a drug that can deplete catecholamines (e.g., reserpine and monoamine oxidase inhibitors) should be observed closely for signs of hypotension and/or severe bradycardia.

Output: <agents with b-blocking properties, effect, reserpine>, <agents with b-blocking properties, effect, monoamine oxidase inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Clonidine: Concomitant administration of clonidine with agents with b-blocking properties may potentiate blood-pressure- and heart-rate-lowering effects.

Output: <clonidine, effect, agents with b-blocking properties>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When concomitant treatment with agents with b-blocking properties and clonidine is to be terminated, the b-blocking agent should be discontinued first.

Output: <agents with b-blocking properties, advise, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporine: Modest increases in mean trough cyclosporine concentrations were observed following initiation of carvedilol treatment in 21 renal transplant patients suffering from chronic vascular rejection.

Output: <cyclosporine, mechanism, carvedilol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Due to wide interindividual variability in the dose adjustment required, it is recommended that cyclosporine concentrations be monitored closely after initiation of carvedilol therapy and that the dose of cyclosporine be adjusted as appropriate.

Output: <cyclosporine, advise, carvedilol>, <carvedilol, advise, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digoxin: Digoxin concentrations are increased by about 15% when digoxin and carvedilol are administered concomitantly.

Output: <digoxin, mechanism, carvedilol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Both digoxin and COREG slow AV conduction.

Output: <digoxin, effect, COREG>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, increased monitoring of digoxin is recommended when initiating, adjusting, or discontinuing COREG.

Output: <digoxin, advise, COREG>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Inducers and Inhibitors of Hepatic Metabolism: Rifampin reduced plasma concentrations of carvedilol by about 70%.

Output: <Rifampin, mechanism, carvedilol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Calcium Channel Blockers: Isolated cases of conduction disturbance (rarely with hemodynamic compromise) have been observed when COREG is co-administered with diltiazem.

Output: <COREG, effect, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: As with other agents with b-blocking properties, if COREG is to be administered orally with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored.

Output: <COREG, advise, verapamil>, <COREG, advise, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Insulin or Oral Hypoglycemics: Agents with b-blocking properties may enhance the blood-sugar-reducing effect of insulin and oral hypoglycemics.

Output: <Agents with b-blocking properties, effect, insulin>, <Agents with b-blocking properties, effect, hypoglycemics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Elevated plasma levels of theophylline have been reported with concomitant quinolone use.

Output: <theophylline, mechanism, quinolone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been reports of theophylline-related side effects in patients on concomitant therapy with norfloxacin and theophylline.

Output: <norfloxacin, effect, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with norfloxacin.

Output: <cyclosporine, mechanism, norfloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Quinolones, including norfloxacin, may enhance the effects of oral anticoagulants, including warfarin or its derivatives or similar agents.

Output: <Quinolones, effect, anticoagulants>, <Quinolones, effect, warfarin>, <norfloxacin, effect, anticoagulants>, <norfloxacin, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant administration of quinolones including norfloxacin with glyburide (a sulfonylurea agent) has, on rare occasions, resulted in severe hypoglycemia.

Output: <quinolones, effect, glyburide>, <norfloxacin, effect, glyburide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diminished urinary excretion of norfloxacin has been reported during the concomitant administration of probenecid and norfloxacin.

Output: <probenecid, mechanism, norfloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant use of nitrofurantoin is not recommended since nitrofurantoin may antagonize the antibacterial effect of Norfloxacin in the urinary tract.

Output: <nitrofurantoin, effect, Norfloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Multivitamins, or other products containing iron or zinc, antacids or sucralfate should not be administered concomitantly with, or within 2 hours of, the administration of norfloxacin, because they may interfere with absorption resulting in lower serum and urine levels of norfloxacin.

Output: <Multivitamins, advise, norfloxacin>, <iron, advise, norfloxacin>, <zinc, advise, norfloxacin>, <antacids, advise, norfloxacin>, <sucralfate, advise, norfloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Videx (Didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be administered concomitantly with, or within 2 hours of, the administration of norfloxacin, because these products may interfere with absorption resulting in lower serum and urine levels of norfloxacin.

Output: <Videx, advise, norfloxacin>, <Didanosine, advise, norfloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Some quinolones have also been shown to interfere with the metabolism of caffeine.

Output: <quinolones, mechanism, caffeine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Interactions attributed to the combined use of baclofen injection and epidural morphine include hypotension and dyspnea.

Output: <baclofen, effect, morphine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended that the combination of intravenous dantrolene sodium and calcium channel blockers, such as verapamil, not be used together during the management of malignant hyperthermia crisis until the relevance of these findings to humans is established.

Output: <dantrolene sodium, advise, calcium channel blockers>, <dantrolene sodium, advise, verapamil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of dantrolene may potentiate vecuronium-induced neuromuscular block.

Output: <dantrolene, effect, vecuronium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The vasodilating effects of nitroglycerin may be additive with those of other vasodilators.

Output: <nitroglycerin, effect, vasodilators>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination.

Output: <calcium channel blockers, effect, nitrates>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients receiving nonselective monoamine oxidase inhibitors (MAOIs) (e.g., selegiline hydrochloride) in combination with serotoninergic agents (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine), there have been reports of serious, sometimes fatal, reactions.

Output: <monoamine oxidase inhibitors, effect, serotoninergic agents>, <monoamine oxidase inhibitors, effect, fluoxetine>, <monoamine oxidase inhibitors, effect, fluvoxamine>, <monoamine oxidase inhibitors, effect, paroxetine>, <monoamine oxidase inhibitors, effect, sertraline>, <monoamine oxidase inhibitors, effect, venlafaxine>, <MAOIs, effect, serotoninergic agents>, <MAOIs, effect, fluoxetine>, <MAOIs, effect, fluvoxamine>, <MAOIs, effect, paroxetine>, <MAOIs, effect, sertraline>, <MAOIs, effect, venlafaxine>, <selegiline hydrochloride, effect, serotoninergic agents>, <selegiline hydrochloride, effect, fluoxetine>, <selegiline hydrochloride, effect, fluvoxamine>, <selegiline hydrochloride, effect, paroxetine>, <selegiline hydrochloride, effect, sertraline>, <selegiline hydrochloride, effect, venlafaxine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because dexfenfluramine is a serotonin releaser and reuptake inhibitor, dexfenfluramine should not be used concomitantly with a MAO inhibitor.

Output: <dexfenfluramine, advise, MAO inhibitor>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: At least 14 days should elapse between discontinuation of a MAO inhibitor and initiation of treatment with dexfenfluramine.

Output: <MAO inhibitor, advise, dexfenfluramine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: At least 3 weeks should elapse between discontinuation of dexfenfluramine and initiation of treatment with a MAO inhibitor.

Output: <dexfenfluramine, advise, MAO inhibitor>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A rare, but serious, constellation of symptoms, termed serotonin syndrome, has been reported with the concomitant use of selective serotonin reuptake inhibitors (SSRIs) and agents for migraine therapy, such as Imitrex (sumatriptan succinate) and dihydroergotamine.

Output: <selective serotonin reuptake inhibitors, effect, Imitrex>, <selective serotonin reuptake inhibitors, effect, sumatriptan succinate>, <selective serotonin reuptake inhibitors, effect, dihydroergotamine>, <SSRIs, effect, Imitrex>, <SSRIs, effect, sumatriptan succinate>, <SSRIs, effect, dihydroergotamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dexfenfluramine should not be administered with other serotoninergic agents.

Output: <Dexfenfluramine, advise, serotoninergic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Itraconazole decreases busulfan clearance by up to 25%, and may produce AUCs   1500  M min in some patients.

Output: <Itraconazole, mechanism, busulfan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin increases the clearance of busulfan by 15% or more, possibly due to the induction of glutathione-S-transferase.

Output: <Phenytoin, mechanism, busulfan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since the pharmacokinetics of BUSULFEX were studied in patients treated with phenytoin, the clearance of BUSULFEX at the recommended dose may be lower and exposure (AUC) higher in patients not treated with phenytoin.

Output: <BUSULFEX, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because busulfan is eliminated from the body via conjugation with glutathione, use of acetaminophen prior to ( 72 hours) or concurrent with BUSULFEX may result in reduced busulfan clearance based upon the known property of acetaminophen to decrease glutathione levels in the blood and tissues.

Output: <acetaminophen, mechanism, BUSULFEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Trecator has been found to temporarily raise serum concentrations of isoniazid.

Output: <Trecator, mechanism, isoniazid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Trecator may potentiate the adverse effects of other antituberculous drugs administered concomitantly.

Output: <Trecator, effect, antituberculous drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In particular, convulsions have been reported when ethionamide is administered with cycloserine and special care should be taken when the treatment regimen includes both of these drugs.

Output: <ethionamide, effect, cycloserine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Danazol: The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol particularly with higher doses of lovastatin (see WARNINGS, Myopathy/Rhabdomyolysis).

Output: <danazol, effect, lovastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Amiodarone or Verapamil: The risk of myopathy/rhabdomyolysis is increased when either amiodarone or verapamil is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS, Myopathy/Rhabdomyolysis).

Output: <amiodarone, effect, HMG-CoA reductase inhibitor class>, <verapamil, effect, HMG-CoA reductase inhibitor class>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, another HMG-CoA reductase inhibitor has been found to produce a less than two-second increase in prothrombin time in healthy volunteers receiving low doses of warfarin.

Output: <HMG-CoA reductase inhibitor, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Also, bleeding and/or increased prothrombin time have been reported in a few patients taking coumarin anticoagulants concomitantly with lovastatin.

Output: <coumarin anticoagulant, effect, lovastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended that in patients taking anticoagulants, prothrombin time be determined before starting lovastatin and frequently enough during early therapy to insure that no significant alteration of prothrombin time occurs.

Output: <anticoagulants, advise, lovastatin>