Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, when meclofenamate sodium is given to a patient receiving warfarin, the dosage of warfarin should be reduced to prevent excessive prolongation of the prothrombin time.

Output: <meclofenamate sodium, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: Concurrent administration of aspirin may lower meclofenamate sodium plasma levels, possibly by competing for protein-binding sites.

Output: <aspirin, mechanism, meclofenamate sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

Output: <oxyphenbutazone, mechanism, androgens>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements.

Output: <androgens, effect, insulin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Bacteriostatic Antibiotics: Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins.

Output: <Chloramphenicol, effect, penicillins>, <erythromycins, effect, penicillins>, <sulfonamides, effect, penicillins>, <tetracyclines, effect, penicillins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid: May decrease renal tubular secretion of ampicillin resulting in increased blood levels and/or ampicillin toxicity.

Output: <Probenecid, mechanism, ampicillin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digoxin: In controlled studies in healthy volunteers, bepridil hydrochloride either had no effect (one study) or was associated with modest increases, about 30% (two studies) in steady-state serum digoxin concentrations.

Output: <bepridil hydrochloride, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anti-arrhythmics and tricyclic anti-depressants could exaggerate the prolongation of the QT interval observed with bepridil hydrochloride.

Output: <Anti-arrhythmics, effect, bepridil hydrochloride>, <tricyclic anti-depressants, effect, bepridil hydrochloride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cardiac glycosides could exaggerate the depression of AV nodal conduction observed with bepridil hydrochloride.

Output: <Cardiac glycosides, effect, bepridil hydrochloride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.

Output: <Tetracycline, effect, penicillin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta-blockers, clonidine, lithium salts, and alcohol may either potentiate or weaken the blood-glucose-lowering effect of insulin.

Output: <Beta-blockers, effect, insulin>, <clonidine, effect, insulin>, <lithium, effect, insulin>, <alcohol, effect, insulin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dopamine D2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone) and isoniazid may reduce the therapeutic effects of levodopa.

Output: <Dopamine D2 receptor antagonists, effect, levodopa>, <phenothiazines, effect, levodopa>, <butyrophenones, effect, levodopa>, <risperidone, effect, levodopa>, <isoniazid, effect, levodopa>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition, the beneficial effects of levodopa in Parkinsons disease have been reported to be reversed by phenytoin and papaverine.

Output: <levodopa, effect, phenytoin>, <levodopa, effect, papaverine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Iron salts may reduce the bioavailability of carbidopa and levodopa.

Output: <Iron, mechanism, carbidopa>, <Iron, mechanism, levodopa>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although metoclopramide may increase the bioavailability of levodopa by increasing gastric emptying, metoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.

Output: <metoclopramide, mechanism, levodopa>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since hydroxyurea may raise the serum uric acid level, dosage adjustment of uricosuric medication may be necessary

Output: <hydroxyurea, effect, uricosuric medication>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent use with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir.

Output: <probenecid, mechanism, penciclovir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics.

Output: <aminoglycoside antibiotics, effect, cephalosporin antibiotics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of probenecid doubled the AUC for cefprozil.

Output: <probenecid, mechanism, cefprozil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Both the magnitude and duration of central nervous system and cardiovascular effects may be enhanced when ALFENTA is administered in combination with other CNS depressants such as barbiturates, tranquilizers, opioids, or inhalation general anesthetics.

Output: <ALFENTA, effect, CNS depressants>, <ALFENTA, effect, barbiturates>, <ALFENTA, effect, tranquilizers>, <ALFENTA, effect, opioids>, <ALFENTA, effect, anesthetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Limited clinical experience indicates that requirements for volatile inhalation anesthetics are reduced by 30 to 50% for the first sixty (60) minutes following ALFENTA induction The concomitant use of erythromycin with ALFENTA can significantly inhibit ALFENTA clearance and may increase the risk of prolonged or delayed respiratory depression.

Output: <volatile inhalation anesthetics, mechanism, ALFENTA>, <erythromycin, mechanism, ALFENTA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine reduces the clearance of ALFENTA.

Output: <Cimetidine, mechanism, ALFENTA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diphenoxylate HCl and atropine sulfate may interact with MAO inhibitors In studies with male rats, diphenoxylate hydrochloride was found to inhibit the hepatic microsomal enzyme system at a dose of 2 mg/kg/day.

Output: <Diphenoxylate HCl, int, MAO inhibitors>, <atropine sulfate, int, MAO inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although deferasirox has a lower affinity for aluminum than for iron, Exjade should not be taken with aluminum-containing antacid preparations.

Output: <Exjade, advise, aluminum>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The use of codeine may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.

Output: <codeine, effect, alcohol>, <codeine, effect, antihistamines>, <codeine, effect, psychotropics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Serious toxicity may result if dextromethorphan is coadministered with monoamine oxidase inhibitors (MAOIs).

Output: <dextromethorphan, effect, monoamine oxidase inhibitors>, <dextromethorphan, effect, MAOIs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The use of dextromethorphan hydrobromide may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.

Output: <dextromethorphan hydrobromide, effect, alcohol>, <dextromethorphan hydrobromide, effect, antihistamines>, <dextromethorphan hydrobromide, effect, psychotropics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cholestyramine resin may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic) or propranolol (basic), as well as tetracycline penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis.

Output: <Cholestyramine, mechanism, phenylbutazone>, <Cholestyramine, mechanism, warfarin>, <Cholestyramine, mechanism, thiazide diuretics>, <Cholestyramine, mechanism, propranolol>, <Cholestyramine, mechanism, tetracycline>, <Cholestyramine, mechanism, penicillin G>, <Cholestyramine, mechanism, phenobarbital>, <Cholestyramine, mechanism, thyroxine>, <Cholestyramine, mechanism, estrogens>, <Cholestyramine, mechanism, progestins>, <Cholestyramine, mechanism, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cholestyramine resin may interfere with the pharmacokinetics of drugs that undergo enterohepatic circulation, The discontinuance of cholestyramine resin could pose a hazard to health if a potentially toxic drug such as digitalis has been filtrated to a maintenance level while the patient was taking cholestyramine resin.

Output: <cholestyramine, mechanism, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Agents that are CYP3A4 inhibitors that have been found, or are expected, to increase plasma levels of EQUETROTM are the following: Acetazolamide, azole antifungals, cimetidine, clarithromycin(1), dalfopristin, danazol, delavirdine, diltiazem, erythromycin(1), fluoxetine, fluvoxamine, grapefruit juice, isoniazid, itraconazole, ketoconazole, loratadine, nefazodone, niacinamide, nicotinamide, protease inhibitors, propoxyphene, quinine, quinupristin, troleandomycin, valproate(1), verapamil, zileuton.

Output: <EQUETROTM, mechanism, Acetazolamide>, <EQUETROTM, mechanism, azole antifungals>, <EQUETROTM, mechanism, cimetidine>, <EQUETROTM, mechanism, clarithromycin>, <EQUETROTM, mechanism, dalfopristin>, <EQUETROTM, mechanism, danazol>, <EQUETROTM, mechanism, delavirdine>, <EQUETROTM, mechanism, diltiazem>, <EQUETROTM, mechanism, erythromycin>, <EQUETROTM, mechanism, fluoxetine>, <EQUETROTM, mechanism, fluvoxamine>, <EQUETROTM, mechanism, isoniazid>, <EQUETROTM, mechanism, itraconazole>, <EQUETROTM, mechanism, ketoconazole>, <EQUETROTM, mechanism, loratadine>, <EQUETROTM, mechanism, nefazodone>, <EQUETROTM, mechanism, niacinamide>, <EQUETROTM, mechanism, nicotinamide>, <EQUETROTM, mechanism, protease inhibitors>, <EQUETROTM, mechanism, propoxyphene>, <EQUETROTM, mechanism, quinine>, <EQUETROTM, mechanism, quinupristin>, <EQUETROTM, mechanism, troleandomycin>, <EQUETROTM, mechanism, valproate>, <EQUETROTM, mechanism, verapamil>, <EQUETROTM, mechanism, zileuton>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Agents that are CYP inducers that have been found, or are expected, to decrease plasma levels of EQUETROTM are the following: Cisplatin, doxorubicin HCL, felbamate, rifampin, phenobarbital, Phenytoin(2), primidone, methsuximide, and theophylline Thus, if a patient has been titrated to a stable dosage on EQUETROTM, and then begins a course of treatment with one of these CYP3A4 inducers, it is reasonable to expect that a dose increase for EQUETROTM may be necessary.

Output: <EQUETROTM, mechanism, Cisplatin>, <EQUETROTM, mechanism, doxorubicin HCL>, <EQUETROTM, mechanism, felbamate>, <EQUETROTM, mechanism, rifampin>, <EQUETROTM, mechanism, phenobarbital>, <EQUETROTM, mechanism, Phenytoin>, <EQUETROTM, mechanism, primidone>, <EQUETROTM, mechanism, methsuximide>, <EQUETROTM, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Agents that have been found, or are expected to have decreased plasma levels in the presence of EQUETROTM due to induction of CYP enzymes are the following: Acetaminophen, alprazolam, amitriptyline, bupropion, buspirone, citalopram, clobazam, clonazepam, clozapine, cyclosporin, delavirdine, desipramine, diazepam, dicumarol, doxycycline, ethosuximide, felbamate, felodipine, glucocorticoids, haloperidol, itraconazole, lamotrigine, levothyroxine, lorazepam, methadone, midazolam, mirtazapine, nortriptyline, olanzapine, oral contraceptives(3), oxcarbazepine, Phenytoin(4), praziquantel, protease inhibitors, quetiapine, risperidone, theophylline, topiramate, tiagabine, tramadol, triazolam, valproate, warfarin(5) , ziprasidone, and zonisamide.

Output: <EQUETROTM, mechanism, Acetaminophen>, <EQUETROTM, mechanism, alprazolam>, <EQUETROTM, mechanism, amitriptyline>, <EQUETROTM, mechanism, bupropion>, <EQUETROTM, mechanism, buspirone>, <EQUETROTM, mechanism, citalopram>, <EQUETROTM, mechanism, clobazam>, <EQUETROTM, mechanism, clonazepam>, <EQUETROTM, mechanism, clozapine>, <EQUETROTM, mechanism, cyclosporin>, <EQUETROTM, mechanism, delavirdine>, <EQUETROTM, mechanism, desipramine>, <EQUETROTM, mechanism, diazepam>, <EQUETROTM, mechanism, dicumarol>, <EQUETROTM, mechanism, doxycycline>, <EQUETROTM, mechanism, ethosuximide>, <EQUETROTM, mechanism, felbamate>, <EQUETROTM, mechanism, felodipine>, <EQUETROTM, mechanism, glucocorticoids>, <EQUETROTM, mechanism, haloperidol>, <EQUETROTM, mechanism, itraconazole>, <EQUETROTM, mechanism, lamotrigine>, <EQUETROTM, mechanism, levothyroxine>, <EQUETROTM, mechanism, lorazepam>, <EQUETROTM, mechanism, methadone>, <EQUETROTM, mechanism, midazolam>, <EQUETROTM, mechanism, mirtazapine>, <EQUETROTM, mechanism, nortriptyline>, <EQUETROTM, mechanism, olanzapine>, <EQUETROTM, mechanism, contraceptives>, <EQUETROTM, mechanism, oxcarbazepine>, <EQUETROTM, mechanism, Phenytoin>, <EQUETROTM, mechanism, praziquantel>, <EQUETROTM, mechanism, protease inhibitors>, <EQUETROTM, mechanism, quetiapine>, <EQUETROTM, mechanism, risperidone>, <EQUETROTM, mechanism, theophylline>, <EQUETROTM, mechanism, topiramate>, <EQUETROTM, mechanism, tiagabine>, <EQUETROTM, mechanism, tramadol>, <EQUETROTM, mechanism, triazolam>, <EQUETROTM, mechanism, valproate>, <EQUETROTM, mechanism, warfarin>, <EQUETROTM, mechanism, ziprasidone>, <EQUETROTM, mechanism, zonisamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Agents with Increased Levels in the Presence of Carbamazepine: EQUETROTM increases the plasma levels of the following agents: Clomipramine HCl, Phenytoin(6), and primidone Thus, if a patient has been titrated to a stable dosage on one of the agents in this category, and then begins a course of the treatment with EQUETROTM, it is reasonable to expect that a dose decrease for the concomitant agent may be necessary.

Output: <EQUETROTM, mechanism, Clomipramine HCl>, <EQUETROTM, mechanism, Phenytoin>, <EQUETROTM, mechanism, primidone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pharmacological/Pharmacodynamic Interactions with Carbamazepine Concomitant administration of carbamazepine and lithium may increase the risk of neurotoxic side effects.

Output: <carbamazepine, effect, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Additionally, anti-malarial drugs, such as chloroquine and mefloquine, may antagonize the activity of carbamazepine.

Output: <anti-malarial drugs, effect, carbamazepine>, <chloroquine, effect, carbamazepine>, <mefloquine, effect, carbamazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because of its primary CNS effect, caution should be used when EQUETROTM is taken with other centrally acting drugs and alcohol.

Output: <EQUETROTM, advise, centrally acting drugs>, <EQUETROTM, advise, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients receiving another serotonin reuptake inhibitor drug in combination with monoamine oxidase inhibitors (MAOI), there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma.

Output: <serotonin reuptake inhibitor drug, effect, monoamine oxidase inhibitors>, <serotonin reuptake inhibitor drug, effect, MAOI>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, it is recommended that Fluvoxamine Tablets not be used in combination with MAOIs, or within 14 days of discontinuing treatment with a MAOI.

Output: <Fluvoxamine, advise, MAOIs>, <Fluvoxamine, advise, MAOI>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: After stopping Fluvoxamine Tablets, at least 2 weeks should be allowed before starting a MAOI.

Output: <Fluvoxamine, advise, MAOI>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Terfenadine, astemizole and cisapride are all metabolized by the cytochrome P450IIIA4 isozyme, and it has been demonstrated that ketoconazole, a potent inhibitor of IIIA4, blocks the metabolism of these drugs, resulting in increased plasma concentrations of parent drug.

Output: <Terfenadine, mechanism, ketoconazole>, <astemizole, mechanism, ketoconazole>, <cisapride, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although it has not been definitively demonstrated that fluvoxamine is a potent IIIA4 inhibitor, it is likely to be, given the substantial interaction of fluvoxamine with alprazolam.

Output: <fluvoxamine, int, alprazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Consequently, it is recommended that fluvoxamine not be used in combination with either terbinafine, astemizole, or cisapride.

Output: <fluvoxamine, advise, terbinafine>, <fluvoxamine, advise, astemizole>, <fluvoxamine, advise, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other Potentially Important Drug Interactions: Benzodiazepines: Benzodiazepines metabolized by hepatic oxidation (e.g., alprazolam, midazolam, triazolam elc.) should be used with caution because the clearance of these drugs is likely to be reduced by fluvoxamine.

Output: <Benzodiazepines, mechanism, fluvoxamine>, <alprazolam, mechanism, fluvoxamine>, <midazolam, mechanism, fluvoxamine>, <triazolam, mechanism, fluvoxamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Alprazolam: When fluvoxamine maleate (100 mg qd) and alprazolam (1 mg q.d. were co-administered to steady state, plasma concentration and other pharmacokinetics parameters (AUC, Cmax, T1/2,) of alprazolam were approximately twice those observed when alprazolam was administered alone;

Output: <fluvoxamine maleate, mechanism, alprazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This interaction, which has not been investigated using higher doses of fluvoxamine, may be more pronounced if a 300 mg daily dose is co-administered, particularly since fluvoxamine exhibits non-linear pharmacokinetics over the dosage range 100-300 mg. If alprazolam is co-administered with Fluvoxamine Tablets, the initial alprazolam dosage should be at least halved and titration to the lowest effective dose is recommended.

Output: <alprazolam, advise, Fluvoxamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diazepam: The co-administration of Fluvoxamine Tablets and diazepam is generally not advisable.

Output: <Fluvoxamine, advise, diazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because fluvoxamine reduces the clearance of both diazepam and its active metabolite, N-desmethyldiazepam, there is a strong likelihood of substantial accumulation of both species during chronic co-administration.

Output: <fluvoxamine, mechanism, diazepam>, <fluvoxamine, mechanism, N-desmethyldiazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Evidence supporting the conclusion that it is inadvisable to co-administer fluvoxamine and diazepam is derived from a study in which healthy volunteers taking 150 mg/day of fluvoxamine were administered a single oral dose of 10 mg of diazepam.

Output: <fluvoxamine, advise, diazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Moreover, as noted with alprazolam, the effect of fluvoxamine may even be more pronounced when it is administered at higher doses.

Output: <alprazolam, effect, fluvoxamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Accordingly, diazepam and fluvoxamine should not ordinarily be co-administered.

Output: <diazepam, advise, fluvoxamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, if theophylline is co-administered with fluvoxamine maleate, its dose should be reduced to one third of the usual daily maintenance dose and plasma concentrations of theophylline should to monitored.

Output: <theophylline, advise, fluvoxamine maleate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin: When fluvoxamine maleate (50 mg tid) was administered concomitantly with warfarin for two weeks, warfarin plasma concentrations increased by 98% and prothrombin times were prolonged.

Output: <fluvoxamine maleate, mechanism, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus patients receiving oral anticoagulants and Fluvoxamine Tablets should have their prothrombin time monitored and their anticoagulant dose adjusted accordingly.

Output: <anticoagulants, advise, Fluvoxamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, caution should be used when administering nitazoxanide concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur (e.g., warfarin).

Output: <nitazoxanide, mechanism, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The most commonly occurring drug interactions are listed below: - Drugs that may increase plasma phenytoin concentrations include: acute alcohol intake, amiodarone, chboramphenicol, chlordiazepoxide, cimetidine, diazepam, dicumarol, disulfiram, estrogens, ethosuximide, fluoxetine, H2-antagonists, halothane, isoniazid, methylphenidate, phenothiazines, phenylbutazone, salicylates, succinimides, sulfonamides, tolbutamide, trazodone

Output: <phenytoin, mechanism, alcohol>, <phenytoin, mechanism, amiodarone>, <phenytoin, mechanism, chlordiazepoxide>, <phenytoin, mechanism, cimetidine>, <phenytoin, mechanism, diazepam>, <phenytoin, mechanism, dicumarol>, <phenytoin, mechanism, disulfiram>, <phenytoin, mechanism, estrogens>, <phenytoin, mechanism, ethosuximide>, <phenytoin, mechanism, fluoxetine>, <phenytoin, mechanism, H2-antagonists>, <phenytoin, mechanism, halothane>, <phenytoin, mechanism, isoniazid>, <phenytoin, mechanism, methylphenidate>, <phenytoin, mechanism, phenothiazines>, <phenytoin, mechanism, phenylbutazone>, <phenytoin, mechanism, salicylates>, <phenytoin, mechanism, succinimides>, <phenytoin, mechanism, sulfonamides>, <phenytoin, mechanism, tolbutamide>, <phenytoin, mechanism, trazodone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Drugs that may decrease plasma phenytoin concentrations include: carbamazepine, chronic alcohol abuse, reserpine

Output: <phenytoin, mechanism, carbamazepine>, <phenytoin, mechanism, alcohol>, <phenytoin, mechanism, reserpine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Drugs that may either increase or decrease plasma phenytoin concentrations include: phenobarbital, vaiproic acid, and sodium valproate.

Output: <phenytoin, mechanism, phenobarbital>, <phenytoin, mechanism, sodium valproate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Similarly, the effects of phenytoin on phenobarbital, valproic acid and sodium plasma valproate concentrations are unpredictable

Output: <phenytoin, effect, phenobarbital>, <phenytoin, effect, valproic acid>, <phenytoin, effect, valproate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Although not a true drug interaction, tricyclic antidepressants may precipitate seizures in susceptible patients and Cerebyx dosage may need to be adjusted

Output: <tricyclic antidepressants, effect, Cerebyx>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Drugs whose efficacy is impaired by phenytoin include: anticoagulants, corticosteroids, coumarin, digitoxin, doxycycline, estrogens, furosemide, oral contraceptives, rifampin, quinidine, theophylline, vitamin D.

Output: <phenytoin, effect, anticoagulants>, <phenytoin, effect, corticosteroids>, <phenytoin, effect, coumarin>, <phenytoin, effect, digitoxin>, <phenytoin, effect, doxycycline>, <phenytoin, effect, estrogens>, <phenytoin, effect, furosemide>, <phenytoin, effect, contraceptives>, <phenytoin, effect, rifampin>, <phenytoin, effect, quinidine>, <phenytoin, effect, theophylline>, <phenytoin, effect, vitamin D>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Catecholamine-depleting drugs (eg, reserpine) may have an additive effect when given with beta-blocking agents.

Output: <reserpine, effect, beta-blocking agent>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Calcium channel blockers may also have an additive effect when given with TENORMIN .

Output: <Calcium channel blockers, effect, TENORMIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.

Output: <Beta blockers, effect, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If the two drugs are coadministered, the beta blocker should be withdrawn several days before the gradual withdrawal of clonidine.

Output: <beta blocker, advise, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If replacing clonidine by beta-blocker therapy, the introduction of beta blockers should be delayed for several days after clonidine administration has stopped.

Output: <beta blockers, advise, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of prostaglandin synthase inhibiting drugs, eg, indomethacin, may decrease the hypotensive effects of beta blockers.

Output: <indomethacin, effect, beta blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Interactions may occur between EPA supplements and aspirin and other non-steroidal anti-inflammatory drugs and herbs such as garlic (Allium sativum) and ginkgo (Ginkgo biloba).

Output: <EPA, int, aspirin>, <EPA, int, non-steroidal anti-inflammatory drugs>, <EPA, int, ginkgo>, <EPA, int, Ginkgo biloba>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When administered concurrently, the following drugs may interact with amphotericin B: Antineoplastic agents: may enhance the potential for renal toxicity, bronchospasm and hypotension.

Output: <amphotericin B, effect, Antineoplastic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticosteroids and Corticotropin (ACTH): may potentiate amphotericin B- induced hypokalemia which may predispose the patient to cardiac dysfunction.

Output: <Corticosteroids, effect, amphotericin B>, <Corticotropin, effect, amphotericin B>, <ACTH, effect, amphotericin B>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digitalis glycosides: amphotericin B-induced hypokalemia may potentiate digitalis toxicity.

Output: <amphotericin B, effect, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Flucytosine: while a synergistic relationship with amphotericin B has been reported, concomitant use may increase the toxicity of flucytosine by possibly increasing its cellular uptake and/or impairing its renal excretion.

Output: <amphotericin B, effect, flucytosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Imidazoles (e. g., ketoconazole, miconazole, clotrimazole, fluconazole, etc.): in vitro and animal studies with the combination of amphotericin B and imidazoles suggest that imidazoles may induce fungal resistance to amphotericin B.

Output: <imidazoles, effect, amphotericin B>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Skeletal muscle relaxants: amphotericin B-induced hypokalemia may enhance the curariform effect of skeletal muscle relaxants (e.g., tubocurarine).

Output: <amphotericin B, effect, skeletal muscle relaxants>, <amphotericin B, effect, tubocurarine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Leukocyte transfusions: acute pulmonary toxicity has been reported in patients receiving intravenous amphotericin B and leukocyte transfusions.

Output: <amphotericin B, effect, leukocyte transfusions>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The absorption of lymecycline may be affected by the simultaneous administration of indigestion remedies, iron or zinc supplements.

Output: <lymecycline, mechanism, iron>, <lymecycline, mechanism, zinc>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oral contraceptives may be less effective while you are taking lymecycline.

Output: <contraceptives, effect, lymecycline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Additional reductions in blood pressure may occur when FLOLAN is administered with diuretics, antihypertensive agents, or other vasodilators.

Output: <FLOLAN, effect, diuretics>, <FLOLAN, effect, antihypertensive agents>, <FLOLAN, effect, vasodilators>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When other antiplatelet agents or anticoagulants are used concomitantly, there is the potential for FLOLAN to increase the risk of bleeding.

Output: <antiplatelet agents, effect, FLOLAN>, <anticoagulants, effect, FLOLAN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In clinical trials, FLOLAN was used with digoxin, diuretics, anticoagulants, oral vasodilators, and supplemental oxygen.In a pharmacokinetic substudy in patients with congestive heart failure receiving furosemide or digoxin in whom therapy with FLOLAN was initiated, apparent oral clearance values for furosemide (n = 23) and digoxin (n = 30) were decreased by 13% and 15%, respectively, on the second day of therapy and had returned to baseline values by day 87.

Output: <furosemide, mechanism, FLOLAN>, <digoxin, mechanism, FLOLAN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, patients on digoxin may show elevations of digoxin concentrations after initiation of therapy with FLOLAN, which may be clinically significant in patients prone to digoxin toxicity.

Output: <digoxin, mechanism, FLOLAN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporine - L-arginine may counteract the antinaturetic effect of cyclosporin.

Output: <L-arginine, effect, cyclosporin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ibuprofen - L-arginine may increase the absorption of ibuprofen if taken concomitantly.

Output: <L-arginine, mechanism, ibuprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Organic nitrates - L-arginine supplements theoretically may potentiate the effects of organic nitrates if taken concomitantly.

Output: <L-arginine, effect, nitrates>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sildenafil citrate - Theoretically, L-arginine supplements taken concomitantly with sildenafil citrate, may potentiate the effects of the drug.

Output: <L-arginine, effect, sildenafil citrate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and AXERT within 24 hours of each other should be avoided.

Output: <ergotamine, advise, AXERT>, <ergot-type medications, advise, AXERT>, <dihydroergotamine, advise, AXERT>, <methysergide, advise, AXERT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Monoamine Oxidase Inhibitors: Coadministration of moclobemide resulted in a 27% decrease in almotriptan clearance and an increase in Cmax of approximately 6%.

Output: <moclobemide, mechanism, almotriptan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other 5-HT1B/1D Agonists Concomitant use of other 5-HT1B/1D agonists within 24 hours of treatment with AXERT is contraindicated.

Output: <5-HT1B/1D agonists, advise, AXERT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Selective Serotonin Reuptake Inhibitors (SSRIs): SSRIs (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline) have been rarely reported to cause weakness, hyperreflexia, and incoordination when coadministered with 5-HT1 agonists.

Output: <SSRIs, effect, 5-HT1 agonists>, <fluoxetine, effect, 5-HT1 agonists>, <fluvoxamine, effect, 5-HT1 agonists>, <paroxetine, effect, 5-HT1 agonists>, <sertraline, effect, 5-HT1 agonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If concomitant treatment with AXERT and an SSRI is clinically warranted, appropriate observation of the patient is advised.

Output: <AXERT, advise, SSRI>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Verapamil: Coadministration of almotriptan and verapamil resulted in a 24% increase in plasma concentrations of almotriptan.

Output: <almotriptan, mechanism, verapamil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of almotriptan and the potent CYP3A4 inhibitor ketoconazole (400 mg q.d. for 3 days) resulted in an approximately 60% increase in the area under the plasma concentration-time curve and maximal plasma concentrations of almotriptan.

Output: <almotriptan, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although the interaction between almotriptan and other potent CYP3A4 inhibitors (e.g., itraconazole, ritonavir, and erythromycin) has not been studied, increased exposures to almotriptan may be expected when almotriptan is used concomitantly with these medications.

Output: <itraconazole, advise, almotriptan>, <ritonavir, advise, almotriptan>, <erythromycin, advise, almotriptan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lamivudine and zalcitabine may inhibit the intracellular phosphorylation of one another.

Output: <Lamivudine, effect, zalcitabine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, use of lamivudine in combination with zalcitabine is not recommended

Output: <lamivudine, advise, zalcitabine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Folic acid in large amounts may counteract the antiepileptic effect of phenobarbital, phenytoin and primidone, and increase the frequency of seizures in susceptible pediatric patients.

Output: <Folic acid, effect, phenobarbital>, <Folic acid, effect, phenytoin>, <Folic acid, effect, primidone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, high doses of leucovorin may reduce the efficacy of intrathecally administered methotrexate.

Output: <leucovorin, effect, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Leucovorin may enhance the toxicity of 5-fluorouracil.

Output: <Leucovorin, effect, 5-fluorouracil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The following drug interactions have been identified involving NIZORAL Tablets and other drugs metabolized by the cytochrome P450 3A4 enzyme system: Ketoconazole tablets inhibit the metabolism of terfenadine, resulting in an increased plasma concentration of terfenadine and a delay in the elimination of its acid metabolite.

Output: <Ketoconazole, mechanism, terfenadine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pharmacokinetic data indicate that oral ketoconazole inhibits the metabolism of astemizole, resulting in elevated plasma levels of astemizole and its active metabolite desmethylastemizole which may prolong QT intervals.

Output: <ketoconazole, effect, astemizole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of astemizole with ketoconazole tablets is therefore contraindicated.

Output: <astemizole, advise, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Human pharmacokinetics data indicate that oral ketoconazole potently inhibits the metabolism of cisapride resulting in a mean eight-fold increase in AUC of cisapride.

Output: <ketoconazole, mechanism, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Data suggest that coadministration of oral ketoconazole and cisapride can result in prolongation of the QT interval on the ECG.

Output: <ketoconazole, effect, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore concomitant administration of ketoconazole tablets with cisapride is contraindicated.

Output: <ketoconazole, advise, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole tablets may alter the metabolism of cyclosporine, tacrolimus, and methylprednisolone, resulting in elevated plasma concentrations of the latter drugs.

Output: <Ketoconazole, mechanism, cyclosporine>, <Ketoconazole, mechanism, tacrolimus>, <Ketoconazole, mechanism, methylprednisolone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of NIZORAL  Tablets with midazolam or triazolam has resulted in elevated plasma concentrations of the latter two drugs.

Output: <NIZORAL, mechanism, midazolam>, <NIZORAL, mechanism, triazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is, therefore, advisable to monitor digoxin concentrations in patients receiving ketoconazole.

Output: <digoxin, advise, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When taken orally , imidazole compounds like ketoconazole may enhance the anticoagulant effect of coumarin-like drugs.

Output: <imidazole compounds, effect, coumarin>, <ketoconazole, effect, coumarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In simultaneous treatment with imidazole drugs and coumarin drugs, the anticoagulant effect should be carefully titrated and monitored.

Output: <imidazole drugs, advise, coumarin drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because severe hypoglycemia has been reported in patients concomitantly receiving oral miconazole (an imidazole) and oral hypoglycemic agents, such a potential interaction involving the latter agents when used concomitantly with ketoconazole tablets (an imidazole) can not be ruled out.

Output: <miconazole, effect, hypoglycemic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of ketoconazole tablets with phenytoin may alter the metabolism of one or both of the drugs.

Output: <ketoconazole, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is suggested to monitor both ketoconazole and phenytoin.

Output: <ketoconazole, advise, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of rifampin with ketoconazole tablets reduces the blood levels of the latter.

Output: <rifampin, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: INH (Isoniazid) is also reported to affect ketoconazole concentrations adversely.

Output: <INH, mechanism, ketoconazole>, <Isoniazid, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: After the coadministration of 200 mg oral ketoconazole twice daily and one 20 mg dose of loratadine to 11 subjects, the AUC and Cmax of loratadine averaged 302% (  142 S.D.) and 251% (  68 S.D.), respectively, of those obtained after co-treatment with placebo.

Output: <ketoconazole, mechanism, loratadine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although the occurrence has not been reported with Cefizox, nephrotoxicity has been reported following concomitant administration of other cephalosporins and aminoglycosides.

Output: <cephalosporins, effect, aminoglycosides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response.

Output: <phenobarbital, mechanism, corticosteroids>, <phenobarbital, advise, corticosteroid>, <phenytoin, mechanism, corticosteroids>, <phenytoin, advise, corticosteroid>, <rifampin, mechanism, corticosteroids>, <rifampin, advise, corticosteroid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance.

Output: <troleandomycin, mechanism, corticosteroids>, <ketoconazole, mechanism, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticosteroids may increase the clearance of chronic high dose aspirin.

Output: <Corticosteroids, effect, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn.

Output: <salicylate, effect, corticosteroid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin should be used cautiously in conjunction with cortico-steroids in patients suffering from hypopro-thrombinemia.

Output: <Aspirin, advise, cortico-steroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The effect of corticosteroids on oral anticoagulants is variable.

Output: <corticosteroids, effect, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There are reports of enhanced as well as diminished effects of anticoagulants when given concurrently with corticosteroids.

Output: <anticoagulants, effect, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of BOTOX and aminoglycosides or other agents interfering with neuromuscular transmission (e.g., curare-like compounds) should only be performed with caution as the effect of the toxin may be potentiated.

Output: <BOTOX, advise, aminoglycosides>, <BOTOX, advise, curare-like compounds>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Excessive neuromuscular weakness may be exacerbated by administration of another botulinum toxin prior to the resolution of the effects of a previously administered botulinum toxin.

Output: <botulinum toxin, effect, botulinum toxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Additive adverse effects resulting from cholinergic blockade may occur when LEVSIN is administered concomitantly with other antimuscarinics, amantadine, haloperidol, phenothiazines, monoamine oxidase (MAO) inhibitors, tricyclic antidepressants or some antihistamines.

Output: <LEVSIN, effect, antimuscarinics>, <LEVSIN, effect, amantadine>, <LEVSIN, effect, haloperidol>, <LEVSIN, effect, phenothiazines>, <LEVSIN, effect, monoamine oxidase (MAO) inhibitors>, <LEVSIN, effect, tricyclic antidepressants>, <LEVSIN, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids may interfere with the absorption of LEVSIN.

Output: <Antacids, mechanism, LEVSIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Fluvoxamine increased mean alosetron plasma concentrations (AUC) approximately 6-fold and prolonged the half-life by approximately 3-fold.

Output: <Fluvoxamine, mechanism, alosetron>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of alosetron and fluvoxamine is contraindicated.

Output: <alosetron, advise, fluvoxamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of alosetron and moderate CYP1A2 inhibitors, including quinolone antibiotics and cimetidine, has not been evaluated, but should be avoided unless clinically necessary because of similar potential drug interactions.

Output: <alosetron, advise, quinolone antibiotics>, <alosetron, advise, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole increased mean alosetron plasma concentrations (AUC) by 29%.

Output: <Ketoconazole, mechanism, alosetron>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be used when alosetron and ketoconazole are administered concomitantly.

Output: <alosetron, advise, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of alosetron and strong CYP3A4 inhibitors, such as clarithromycin, telithromycin, protease inhibitors, voriconazole, and itraconazole has not been evaluated but should be undertaken with caution because of similar potential drug interactions.

Output: <alosetron, advise, clarithromycin>, <alosetron, advise, telithromycin>, <alosetron, advise, protease inhibitors>, <alosetron, advise, voriconazole>, <alosetron, advise, itraconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although not studied with alosetron, inhibition of N-acetyltransferase may have clinically relevant consequences for drugs such as isoniazid, procainamide, and hydralazine.

Output: <alosetron, effect, isoniazid>, <alosetron, effect, procainamide>, <alosetron, effect, hydralazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Adenosine: Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine.

Output: <Dipyridamole, mechanism, adenosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cholinesterase Inhibitors: Dipyridamole may counteract the anticholinesterase effect of cholinesterase inhibitors, thereby potentially aggravating myasthenia gravis.

Output: <Dipyridamole, effect, cholinesterase inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticholinergic agents: Although ipratropium bromide is minimally absorbed into the systemic circulation, there is some potential for an additive interaction with concomitantly used anticholinergic medications.

Output: <ipratropium bromide, effect, anticholinergic medications>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution is therefore advised in the coadministration of ATROVENT Inhalation Aerosol with other anticholinergic-containing drugs.

Output: <ATROVENT, advise, anticholinergic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: An encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN, and FBS) followed by irreversible brain damage has occurred in a few patients treated with lithium plus HALDOL.

Output: <lithium, effect, HALDOL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: As with other antipsychotic agents, it should be noted that HALDOL may be capable of potentiating CNS depressants such as anesthetics, opiates, and alcohol.

Output: <antipsychotic agents, effect, CNS depressants>, <antipsychotic agents, effect, anesthetics>, <antipsychotic agents, effect, opiates>, <antipsychotic agents, effect, alcohol>, <HALDOL, effect, CNS depressants>, <HALDOL, effect, anesthetics>, <HALDOL, effect, opiates>, <HALDOL, effect, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a study of 12 schizophrenic patients coadministered oral haloperidol and rifampin, plasma haloperidol levels were decreased by a mean of 70% and mean scores on the Brief Psychiatric Rating Scale were increased from baseline.

Output: <haloperidol, mechanism, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In 5 other schizophrenic patients treated with oral haloperidol and rifampin, discontinuation of rifampin produced a mean 3.3-fold increase in haloperidol concentrations.

Output: <rifampin, mechanism, haloperidol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus, careful monitoring of clinical status is warranted when rifampin is administered or discontinued in haloperidol-treated patients.

Output: <rifampin, advise, haloperidol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: apomorphine - prior ingestion of diphenidol may decrease the emetic response to apomorphine in the treatment of poisoning.

Output: <diphenidol, effect, apomorphine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a placebo-controlled trial in normal volunteers, the administration of a single 1 mg dose of doxazosin on day 1 of a four-day regimen of oral cimetidine (400 mg twice daily) resulted in a 10% increase in mean AUC of doxazosin (p=0.006), and a slight but not statistically significant increase in mean Cmax and mean half-life of doxazosin.

Output: <doxazosin, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines.

Output: <MAO inhibitors, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.

Output: <Antihistamines, effect, alcohol>, <Antihistamines, effect, CNS depressants>, <Antihistamines, effect, hypnotics>, <Antihistamines, effect, sedatives>, <Antihistamines, effect, tranquilizers>, <Antihistamines, effect, antianxiety agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The addition of 540 mg/kg/day of cromolyn sodium (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) to 2.7 mg/kg/day of isoproterenol (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) appears to have increased the incidence of both resorptions and malformations.

Output: <cromolyn sodium, effect, isoproterenol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: For example, since cholestyramine may reduce the gastrointestinal absorption of both the oral anticoagulants and vitamin K, the net effects are unpredictable.

Output: <cholestyramine, mechanism, anticoagulants>, <cholestyramine, mechanism, vitamin K>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chloral hydrate may cause an increased prothrombin response by displacing the anticoagulant from protein binding sites or a diminished prothrombin response through increased metabolism of the unbound drug by hepatic enzyme induction, thus leading to inter-patient variation in ultimate prothrombin effect.

Output: <Chloral hydrate, mechanism, anticoagulant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that have been reported to diminish oral anticoagulant response, ie, decreased prothrom-bin time response, in man significantly include: adrenocortical steroids;

Output: <anticoagulant, effect, adrenocortical steroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that have been reported to diminish oral anticoagulant response, ie, decreased prothrom-bin time response, in man significantly include: adrenocortical steroids;alcohol*;antacids;antihistamines;barbiturates;carbamazepine;chloral hydrate*;chlordiazepoxide;cholestyramine;diet high in vitamin K;diuretics*;ethchlorvynol;glutethimide;griseofulvin;haloperidol;meprobamate;oral contraceptives;paraldehyde;primidone;ranitidine*;rifampin;unreliable prothrombin time determinations;vitamin C;warfarin sodium under-dosage.

Output: <anticoagulant, effect, adrenocortical steroids>, <anticoagulant, effect, alcohol>, <anticoagulant, effect, antacids>, <anticoagulant, effect, antihistamines>, <anticoagulant, effect, barbiturates>, <anticoagulant, effect, carbamazepine>, <anticoagulant, effect, chloral hydrate>, <anticoagulant, effect, chlordiazepoxide>, <anticoagulant, effect, cholestyramine>, <anticoagulant, effect, vitamin K>, <anticoagulant, effect, diuretics>, <anticoagulant, effect, ethchlorvynol>, <anticoagulant, effect, glutethimide>, <anticoagulant, effect, griseofulvin>, <anticoagulant, effect, haloperidol>, <anticoagulant, effect, meprobamate>, <anticoagulant, effect, contraceptives>, <anticoagulant, effect, paraldehyde>, <anticoagulant, effect, primidone>, <anticoagulant, effect, ranitidine>, <anticoagulant, effect, rifampin>, <anticoagulant, effect, vitamin C>, <anticoagulant, effect, warfarin sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that reportedly may increase oral anticoagulant response, ie, increased prothrombin response, in man include:alcohol*;

Output: <anticoagulant, effect, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that reportedly may increase oral anticoagulant response, ie, increased prothrombin response, in man include:alcohol*;allopurinol;aminosalicylic acid;amiodarone;anabolic steroids;antibiotics;bromelains;chloral hydrate*;chlorpropamide;chymotrypsin;cimetidine;cinchophen;clofibrate;dextran;dextrothyroxine;diazoxide;dietary deficiencies;diflunisal;disulfiram;drugs affecting blood elements;ethacrynic acid;fenoprofen;glucagon;hepatotoxic drugs;ibuprofen;indomethacin;influenza virus vaccine;inhalation anesthetics;mefenamic acid;methyldopa;methylphenidate;metronidazole;miconazole;monoamine oxidase inhibitors;nalidixic acid;naproxen;oxolinic acid;oxyphenbutazone;pentoxifylline;phenylbutazone;phenyramidol;phenytoin;prolonged hot weather;prolonged narcotics;pyrazolones;quinidine;quinine;ranitidine*;salicylates;sulfinpyrazone;sulfonamides, long acting;sulindac;thyroid drugs;tolbutamide;triclofos sodium;trimethoprim/sulfamethoxazole;unreliable prothrombin time determinations;warfarin sodium overdosage.

Output: <anticoagulant, effect, alcohol>, <anticoagulant, effect, allopurinol>, <anticoagulant, effect, aminosalicylic acid>, <anticoagulant, effect, amiodarone>, <anticoagulant, effect, anabolic steroids>, <anticoagulant, effect, antibiotics>, <anticoagulant, effect, bromelains>, <anticoagulant, effect, chloral hydrate>, <anticoagulant, effect, chlorpropamide>, <anticoagulant, effect, chymotrypsin>, <anticoagulant, effect, cimetidine>, <anticoagulant, effect, cinchophen>, <anticoagulant, effect, clofibrate>, <anticoagulant, effect, dextran>, <anticoagulant, effect, dextrothyroxine>, <anticoagulant, effect, diazoxide>, <anticoagulant, effect, diflunisal>, <anticoagulant, effect, disulfiram>, <anticoagulant, effect, ethacrynic acid>, <anticoagulant, effect, fenoprofen>, <anticoagulant, effect, glucagon>, <anticoagulant, effect, ibuprofen>, <anticoagulant, effect, indomethacin>, <anticoagulant, effect, influenza virus vaccine>, <anticoagulant, effect, anesthetics>, <anticoagulant, effect, mefenamic acid>, <anticoagulant, effect, methyldopa>, <anticoagulant, effect, methylphenidate>, <anticoagulant, effect, metronidazole>, <anticoagulant, effect, miconazole>, <anticoagulant, effect, monoamine oxidase inhibitors>, <anticoagulant, effect, nalidixic acid>, <anticoagulant, effect, naproxen>, <anticoagulant, effect, oxolinic acid>, <anticoagulant, effect, oxyphenbutazone>, <anticoagulant, effect, pentoxifylline>, <anticoagulant, effect, phenylbutazone>, <anticoagulant, effect, phenyramidol>, <anticoagulant, effect, phenytoin>, <anticoagulant, effect, prolonged narcotics>, <anticoagulant, effect, pyrazolones>, <anticoagulant, effect, quinidine>, <anticoagulant, effect, quinine>, <anticoagulant, effect, ranitidine>, <anticoagulant, effect, salicylates>, <anticoagulant, effect, sulfinpyrazone>, <anticoagulant, effect, sulfonamides>, <anticoagulant, effect, sulindac>, <anticoagulant, effect, thyroid drugs>, <anticoagulant, effect, tolbutamide>, <anticoagulant, effect, triclofos sodium>, <anticoagulant, effect, trimethoprim>, <anticoagulant, effect, sulfamethoxazole>, <anticoagulant, effect, warfarin sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oral anticoagulants may potentiate the hypoglycemic action of hypoglycemic agents, eg, tolbutamide and chlorpropamide, by inhibiting their metabolism in the liver.

Output: <anticoagulants, mechanism, hypoglycemic agents>, <anticoagulants, mechanism, tolbutamide>, <anticoagulants, mechanism, chlorpropamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because oral anticoagulants may interfere with the hepatic metabolism of phenytoin, toxic levels of the anticonvulsant may occur when an oral anticoagulant and phenytoin are administered concurrently.

Output: <anticoagulants, mechanism, phenytoin>, <anticoagulant, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that reduce the number of blood platelets by causing bone marrow depression (such as antineoplastic agents) or drugs which inhibit platelet function (eg, aspirin and other non-steroidal anti-inflammatory drugs, dipyridamole, hydrochloroquine, clofibrate, dextran) may increase the bleeding tendency produced by anticoagulants without altering prothrombin time determinations.

Output: <antineoplastic agents, effect, anticoagulants>, <aspirin, effect, anticoagulants>, <non-steroidal anti-inflammatory drugs, effect, anticoagulants>, <dipyridamole, effect, anticoagulants>, <hydrochloroquine, effect, anticoagulants>, <clofibrate, effect, anticoagulants>, <dextran, effect, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The beneficial effects on arterial thrombus formation from combined therapy with antiplatelet and anticoagulant medication must be weighed against an increased risk of inducing hemorrhage.

Output: <antiplatelet medication, advise, anticoagulant medication>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of naltrexone with Acamprosate produced a 25% increase in AUC and a 33% increase in the Cmax of acamprosate.

Output: <naltrexone, mechanism, Acamprosate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients taking Acamprosate concomitantly with antidepressants more commonly reported both weight gain and weight loss, compared with patients taking either medication alone.

Output: <Acamprosate, effect, antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: All vasopressors should be used cautiously in patients taking monoamine oxidase (MAO) inhibitors.

Output: <vasopressors, advise, monoamine oxidase (MAO) inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Epinephrine should not be administered concomitantly with other sympathomimetic drugs (such as isoproterenol) because of possible additive effects and increased toxicity.

Output: <Epinephrine, advise, sympathomimetic drugs>, <Epinephrine, advise, isoproterenol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of epinephrine to patients receiving cyclopropane or halogenated hydrocarbon general anesthetics such as halothane which sensitize the myocardium, may induce cardiac arrhythmia..

Output: <epinephrine, effect, cyclopropane>, <epinephrine, effect, halogenated hydrocarbon general anesthetics>, <epinephrine, effect, halothane>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Epinephrine also should be used cautiously with other drugs (e.g., digitalis, glycosides) that sensitize the myocardium to the actions of sympathomimetic drugs.

Output: <Epinephrine, advise, digitalis>, <Epinephrine, advise, glycosides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diuretic agents may decrease vascular response to pressor drugs such as epinephrine.

Output: <Diuretic agents, effect, epinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Epinephrine may antagonize the neuron blockade produced by guanethidine resulting in decreased antihypertensive effect and requiring increased dosage of the latter.

Output: <Epinephrine, effect, guanethidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: CANCIDAS reduced the blood AUC0-12 of tacrolimus by approximately 20%, peak blood concentration (Cmax) by 16%, and 12-hour blood concentration (C12hr) by 26% in healthy subjects when tacrolimus (2 doses of 0.1 mg/kg 12 hours apart) was administered on the 10th day of CANCIDAS 70 mg daily, as compared to results from a control period in which tacrolimus was administered alone.

Output: <CANCIDAS, mechanism, tacrolimus>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In two clinical studies, cyclosporine (one 4 mg/kg dose or two 3 mg/kg doses) increased the AUC of caspofungin by approximately 35%.

Output: <cyclosporine, mechanism, caspofungin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There were transient increases in liver ALT and AST when CANCIDAS and cyclosporine were co-administered.

Output: <CANCIDAS, effect, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A drug-drug interaction study with rifampin in healthy volunteers has shown a 30% decrease in caspofungin trough concentrations.

Output: <rifampin, mechanism, caspofungin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients on rifampin should receive 70 mg of CANCIDAS daily.

Output: <rifampin, advise, CANCIDAS>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition, results from regression analyses of patient pharmacokinetic data suggest that co-administration of other inducers of drug clearance (efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine) with CANCIDAS may result in clinically meaningful reductions in caspofungin concentrations.

Output: <efavirenz, mechanism, CANCIDAS>, <nevirapine, mechanism, CANCIDAS>, <phenytoin, mechanism, CANCIDAS>, <dexamethasone, mechanism, CANCIDAS>, <carbamazepine, mechanism, CANCIDAS>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When CANCIDAS is co-administered with inducers of drug clearance, such as efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine, use of a daily dose of 70 mg of CANCIDAS should be considered

Output: <CANCIDAS, advise, efavirenz>, <CANCIDAS, advise, nevirapine>, <CANCIDAS, advise, phenytoin>, <CANCIDAS, advise, dexamethasone>, <CANCIDAS, advise, carbamazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta-adrenergic blocking agents should be withdrawn at least 48 hours before conducting an arbutamine-mediated stress test.

Output: <Beta-adrenergic blocking agents, advise, arbutamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.

Output: <cephalosporins, effect, aminoglycoside antibiotics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticotropin may accentuate the electrolyte loss associated with diuretic therapy.

Output: <Corticotropin, effect, diuretic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is possible that the cardiovascular action of other calcium channel blockers could be enhanced by the addition of Nimotop .

Output: <calcium channel blockers, effect, Nimotop>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In Europe, Nimotop  was observed to occasionally intensify the effect of antihypertensive compounds taken concomitantly by patients suffering from hypertension;

Output: <Nimotop, effect, antihypertensive compounds>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A study in eight healthy volunteers has shown a 50% increase in mean peak nimodipine plasma concentrations and a 90% increase in mean area under the curve, after a one week course of cimetidine at 1,000 mg/day and nimodipine at 90 mg/day.

Output: <cimetidine, mechanism, nimodipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tablets: The benzodiazepines, including lorazepam, produce CNS-depressant effects when administered with such medications as barbiturates or alcohol.

Output: <benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, alcohol>, <lorazepam, effect, barbiturates>, <lorazepam, effect, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Injection: Lorazepam injection, like other injectable benzodiazepines, produces depression of the central nervous system when administered with ethyl alcohol, phenothiazines, barbiturates, MAO inhibitors, and other antidepressants.When scopolamine is used concomitantly with injectable lorazepam, an increased incidence of sedation, hallucinations, and irrational behavior has been observed.

Output: <Lorazepam, effect, ethyl alcohol>, <Lorazepam, effect, phenothiazines>, <Lorazepam, effect, barbiturates>, <Lorazepam, effect, MAO inhibitors>, <Lorazepam, effect, antidepressants>, <benzodiazepines, effect, ethyl alcohol>, <benzodiazepines, effect, phenothiazines>, <benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, MAO inhibitors>, <benzodiazepines, effect, antidepressants>, <scopolamine, effect, lorazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: (See CLINICAL PHARMACOLOGY) Coadministration of Femara and tamoxifen 20 mg daily resulted in a reduction of letrozole plasma levels by 38% on average.

Output: <Femara, mechanism, tamoxifen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Codeine in combination with other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, or other CNS depressants (including alcohol) has additive depressant effects.

Output: <Codeine, effect, narcotic analgesics>, <Codeine, effect, anesthetics>, <Codeine, effect, phenothiazines>, <Codeine, effect, tranquilizers>, <Codeine, effect, sedative-hypnotics>, <Codeine, effect, CNS depressants>, <Codeine, effect, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.

Output: <SSRI, int, TCA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nevertheless, caution is indicated in the co-administration of TCAs with any of the SSRIs and also in switching from one class to the other.

Output: <TCAs, advise, SSRIs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Inhibitors or substrates of CYP2D6 (i.e., quinidine, selective serotonin reuptake inhibitors [SSRIs]) may increase the plasma concentration of doxepin when administered concomitantly.

Output: <quinidine, mechanism, doxepin>, <selective serotonin reuptake inhibitors, mechanism, doxepin>, <SSRIs, mechanism, doxepin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, MAO inhibitors should be discontinued at least two weeks prior to the cautious initiation of therapy with SINEQUAN.

Output: <MAO inhibitors, advise, SINEQUAN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine: Cimetidine has been reported to produce clinically significant fluctuations in steady-state serum concentrations of various tricyclic antidepressants.

Output: <Cimetidine, mechanism, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Serious anticholinergic symptoms (i.e., severe dry mouth, urinary retention and blurred vision) have been associated with elevations in the serum levels of tricyclic antidepressant when cimetidine therapy is initiated.

Output: <tricyclic antidepressant, effect, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Additionally, higher than expected tricyclic antidepressant levels have been observed when they are begun in patients already taking cimetidine.

Output: <tricyclic antidepressant, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients who have been reported to be well controlled on tricyclic antidepressants receiving concurrent cimetidine therapy, discontinuation of cimetidine has been reported to decrease established steady-state serum tricyclic antidepressant levels and compromise their therapeutic effects.

Output: <cimetidine, mechanism, tricyclic antidepressant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Alcohol: It should be borne in mind that alcohol ingestion may increase the danger inherent in any intentional or unintentional SINEQUAN overdosage.

Output: <alcohol, mechanism, SINEQUAN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tolazamide: A case of severe hypoglycemia has been reported in a type II diabetic patient maintained on tolazamide (1 gm/day) 11 days after the addition of doxepin (75 mg/day).

Output: <tolazamide, effect, doxepin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Prolonged recovery time may occur if barbiturates and/or narcotics are used concurrently with ketamine.

Output: <barbiturates, effect, ketamine>, <narcotics, effect, ketamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Isocarboxazid should be administered with caution to patients receiving Antabuse (disulfiram, Wyeth-Ayerst Laboratories).

Output: <Isocarboxazid, advise, Antabuse>, <Isocarboxazid, advise, disulfiram>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a single study, rats given high intraperitoneal doses of an MAO inhibitor plus disulfiram experienced severe toxicity, including convulsions and death.

Output: <MAO inhibitor, effect, disulfiram>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of Isocarboxazid and other psychotropic agents is generally not recommended because of possible potentiating effects.

Output: <Isocarboxazid, advise, psychotropic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anesthetics/Sedatives/Hypnotics/Opioids: Co-administration of PRECEDEX with anesthetics, sedatives, hypnotics, and opioids is likely to lead to an enhancement of effects.

Output: <PRECEDEX, effect, anesthetics>, <PRECEDEX, effect, sedatives>, <PRECEDEX, effect, hypnotics>, <PRECEDEX, effect, opioids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, due to possible pharmacodynamic interactions, when co-administered with PRECEDEX, a reduction in dosage of PRECEDEX on the concomitant anesthetic, sedative, hypnotic or opioid may be required.

Output: <PRECEDEX, advise, anesthetic>, <PRECEDEX, advise, sedative>, <PRECEDEX, advise, hypnotic>, <PRECEDEX, advise, opioid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution is advised in patients receiving concomitant high-dose aspirin and carbonic anhydrase inhibitors, as anorexia, tachypnea, lethargy and coma have been rarely reported due to a possible drug interaction.

Output: <aspirin, advise, carbonic anhydrase inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digoxin and verapamil use may be rarely associated with ventricular fibrillation when combined with Adenocard.

Output: <Digoxin, effect, Adenocard>, <verapamil, effect, Adenocard>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The use of Adenocard in patients receiving digitalis may be rarely associated with ventricular fibrillation.

Output: <Adenocard, effect, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The effects of adenosine are antagonized by methylxanthines such as caffeine and theophylline.

Output: <adenosine, effect, methylxanthines>, <adenosine, effect, caffeine>, <adenosine, effect, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In the presence of these methylxanthines, larger doses of adenosine may be required or adenosine may not be effective.

Output: <methylxanthines, advise, adenosine>, <methylxanthines, advise, adenosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Adenosine effects are potentiated by dipyridamole.

Output: <Adenosine, effect, dipyridamole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus, smaller doses of adenosine may be effective in the presence of dipyridamole.

Output: <adenosine, effect, dipyridamole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: As the primary effect of adenosine is to decrease conduction through the A-V node, higher degrees of heart block may be produced in the presence of carbamazepine.

Output: <adenosine, effect, carbamazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine: In a study in healthy volunteers, a one-week course of cimetidine at 400 mg b.i.d. with a single 5 mg dose of isradipine on the sixth day showed an increase in isradipine mean peak plasma concentrations (36%) and significant increase in area under the curve (50%).

Output: <cimetidine, mechanism, isradipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If isradipine therapy is initiated in a patient currently receiving cimetidine careful monitoring for adverse reactions is advised and downward dose adjustment may be required.

Output: <isradipine, advise, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rifampicin: In a study in healthy volunteers, a six-day course of rifampicin at 600 mg/day followed by a single 5 mg dose of isradipine resulted in a reduction in isradipine levels to below detectable limits.

Output: <rifampicin, mechanism, isradipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If rifampicin therapy is required, isradipine concentrations and therapeutic effects are likely to be markedly reduced or abolished as a consequence of increased metabolism and higher clearance of isradipine.

Output: <rifampicin, mechanism, isradipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Fentanyl Anesthesia: Severe hypotension has been reported during fentanyl anesthesia with concomitant use of a beta blocker and a calcium channel blocker.

Output: <fentanyl, effect, beta blocker>, <fentanyl, effect, calcium channel blocker>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs which induce CYP3A4 activity (eg, phenobarbital, rifampin, rifabutin) would be expected to increase the clearance of efavirenz resulting in lowered plasma concentrations.

Output: <phenobarbital, mechanism, efavirenz>, <rifampin, mechanism, efavirenz>, <rifabutin, mechanism, efavirenz>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In uninfected volunteers, 46% developed rash while receiving SUSTIVA and clarithromycin.

Output: <SUSTIVA, effect, clarithromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Increasing the indinavir dose to 1000 mg every 8 hours does not compensate for the increased indinavir metabolism due to SUSTIVA.

Output: <indinavir, mechanism, SUSTIVA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When indinavir at an increased dose (1000 mg every 8 hours) was given with SUSTIVA (600 mg once daily), the indinavir AUC and Cmin were decreased on average by 33-46% and 39-57%, respectively, compared to when indinavir (800 mg every 8 hours) was given alone.

Output: <indinavir, mechanism, SUSTIVA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A dose increase of lopinavir/ritonavir to 533/133 mg (4 capsules or 6.5 mL) twice daily taken with food is recommended when used in combination with SUSTIVA.

Output: <lopinavir, advise, SUSTIVA>, <ritonavir, advise, SUSTIVA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because the potential interaction of efavirenz with oral contraceptives has not been fully characterized, a reliable method of barrier contraception should be used in addition to oral contraceptives.

Output: <efavirenz, advise, contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Monitoring of liver enzymes is recommended when SUSTIVA is used in combination with ritonavir.

Output: <SUSTIVA, advise, ritonavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Potential for reduction in anticonvulsant and/or efavirenz plasma levels;

Output: <anticonvulsant, mechanism, efavirenz>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: SUSTIVA has the potential to decrease plasma concentrations of itraconazole and ketoconazole.

Output: <SUSTIVA, mechanism, itraconazole>, <SUSTIVA, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Indinavir steady-state Cmax, A.C. and Cmin were decreased by 22%, 38%, and 27%, respectively, by concomitant amprenavir.

Output: <Indinavir, mechanism, amprenavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Saquinavir steady-state Cmax, A.C. and Cmin were increased 21%, decreased 19%, and decreased 48%, respectively, by concomitant amprenavir.

Output: <Saquinavir, mechanism, amprenavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nelfinavir steady-state Cmax, A.C. and Cmin were increased by 12%, 15%, and 14%, respectively, by concomitant amprenavir.

Output: <Nelfinavir, mechanism, amprenavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methadone: Coadministration of amprenavir and methadone can decrease plasma levels of methadone.

Output: <amprenavir, effect, methadone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of amprenavir and methadone as compared to a non-matched historicalcontrol group resulted in a 30%, 27%, and 25% decrease in serum amprenavir AUC, Cmax, andCmin, respectively.

Output: <amprenavir, mechanism, methadone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Laboratory Tests: The combination of Amprenavir and low-dose ritonavir has been associated with elevations of cholesterol and triglycerides, SGOT (AST), and SGPT (ALT) in some patients.

Output: <Amprenavir, effect, ritonavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Appropriate laboratory testing should be considered prior to initiating combination therapy with Amprenavir and ritonavir and at periodic intervals or if any clinical signs or symptoms of hyperlipidemia or elevated liver function tests occur during therapy.

Output: <Amprenavir, advise, ritonavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticotropin may accentuate the electrolyte loss associated with diuretic therapy.

Output: <Corticotropin, effect, diuretic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta-adrenergic Blocking Agents: Experience in over 1400 patients in a non-comparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension or exacerbation of angina.

Output: <nifedipine, effect, beta-blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digitalis: Immediate Release Capsules: Since there have been isolated reports of patients with elevated digoxin levels, and there is a possible interaction between digoxin and nifedipine, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization.

Output: <digoxin, int, nifedipine>, <digoxin, advise, nifedipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Extended Release Tablets: Administration of nifedipine with digoxin increased digoxin levels in 9 of 12 normal volunteers.

Output: <digoxin, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since there have been isolated reports of patients with elevated digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization.

Output: <digoxin, advise, nifedipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Quinidine: Immediate Release Capsules: There have been rare reports of an interaction between quinidine and nifedipine (with a decreased plasma level of quinidine).

Output: <quinidine, mechanism, nifedipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coumarin Anticoagulants: There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered.

Output: <coumarin anticoagulants, effect, nifedipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine: A study in 6 healthy volunteers has shown a significant increase in peak nifedipine plasma levels (80%) and area-under-the-curve (74%) after a 1 week course of cimetidine at 1000 mg per day and nifedipine at 40 mg per day.

Output: <cimetidine, mechanism, nifedipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If nifedipine therapy is initiated in a patient currently receiving cimetidine, cautious titration is advised.

Output: <nifedipine, advise, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins;

Output: <Cholestyramine, mechanism, fat soluble vitamins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia.

Output: <thiazides, effect, vitamin D>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias.

Output: <Vitamin D, advise, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D.

Output: <Ketoconazole, mechanism, vitamin D>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.

Output: <vitamin D, effect, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.

Output: <Magnesium, effect, vitamin D>, <antacids, effect, vitamin D>