Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When the STADOL NS was administered 30 minutes after the sumatriptan nasal spray, the AUC of butorphanol increased 11% and Cmax decreased 18%.

Output: <STADOL NS, mechanism, sumatriptan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: These results suggest that the analgesic effect of STADOL NS may be diminished when it is administered shortly after sumatriptan nasal spray, but by 30 minutes any such reduction in effect should be minimal.

Output: <STADOL NS, effect, sumatriptan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is not known if the effects of butorphanol are altered by concomitant medications that affect hepatic metabolism of drugs (erythromycin, etc.), but physicians should be alert to the possibility that a smaller initial dose and longer intervals between doses may be needed.

Output: <butorphanol, advise, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, a slower onset can be anticipated if STADOL NS is administered concomitantly with, or immediately following, a nasal vasoconstrictor.

Output: <STADOL NS, effect, nasal vasoconstrictor>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hypotension: Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with enalapril or enalaprilat.

Output: <diuretics, effect, enalapril>, <diuretics, effect, enalaprilat>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The possibility of hypotensive effects with enalapril or enalaprilat can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with enalapril or enalaprilat.

Output: <enalapril, effect, diuretic>, <enalaprilat, effect, diuretic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Agents Causing Renin Release: The antihypertensive effect of enalapril and enalapril IV is augmented by antihypertensive agents that cause renin release (e.g., diuretics).

Output: <enalapril, effect, antihypertensive agents>, <enalapril, effect, diuretics>, <enalapril, effect, antihypertensive agents>, <enalapril, effect, diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Non-steroidal Anti-inflammatory Agents: In some patients with compromised renal function who are being treated with nonsteroidal anti-inflammatory drugs, the co-administration of enalapril may result in a further deterioration of renal function.

Output: <nonsteroidal anti-inflammatory drugs, effect, enalapril>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors.

Output: <NSAIDs, effect, ACE inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE inhibitors.

Output: <NSAIDs, advise, ACE inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Agents Increasing Serum Potassium: Enalapril and enalapril IV attenuate potassium loss caused by thiazide-type diuretics.

Output: <Enalapril, effect, thiazide-type diuretics>, <enalapril, effect, thiazide-type diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors.

Output: <lithium, effect, ACE inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended that serum lithium levels be monitored frequently if enalapril is administered concomitantly with lithium.

Output: <enalapril, advise, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12.

Output: <Colchicine, mechanism, vitamin B12>, <para-aminosalicylic acid, mechanism, vitamin B12>, <alcohol, mechanism, vitamin B12>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Uricosuric Agents: Aspirin may decrease the effects of probenecid, sulfinpyrazone, and phenylbutazone.

Output: <Aspirin, effect, probenecid>, <Aspirin, effect, sulfinpyrazone>, <Aspirin, effect, phenylbutazone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Alcohol: Has a synergistic effect with aspirin in causing gastrointestinal bleeding.

Output: <Alcohol, effect, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticosteroids: Concomitant administration with aspirin may increase the risk of gastrointestinal ulceration and may reduce serum salicylate levels.

Output: <Corticosteroids, effect, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pyrazolone Derivatives (phenylbutazone, oxyphenbutazone, and possibly dipyrone): Concomitant administration with aspirin may increase the risk of gastrointestinal ulceration.

Output: <Pyrazolone Derivatives, effect, aspirin>, <phenylbutazone, effect, aspirin>, <oxyphenbutazone, effect, aspirin>, <dipyrone, effect, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nonsteroidal Antiinflammatory Agents: Aspirin is contraindicated in patients who are hypersensitive to nonsteroidal anti-inflammatory agents.

Output: <Aspirin, advise, nonsteroidal anti-inflammatory>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenobarbital: Decreases aspirin effectiveness by enzyme induction.

Output: <Phenobarbital, mechanism, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin: Serum phenytoin levels may be increased by aspirin.

Output: <phenytoin, effect, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Propranolol: May decrease aspirins anti-inflammatory action by competing for the same receptors.

Output: <Propranolol, effect, aspirins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids: Enteric Coated Aspirin should not be given concurrently with antacids, since an increase in the pH of the stomach may effect the enteric coating of the tablets.

Output: <Aspirin, advise, antacids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: conversely, diethylpropion may interfere with antihypertensive drugs (i.e., guanethidine, a-methyldopa).

Output: <diethylpropion, int, antihypertensive drugs>, <diethylpropion, int, guanethidine>, <diethylpropion, int, a-methyldopa>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent use of phenothiazines may antagonize the anorectic effect of diethylpropion.

Output: <phenothiazines, effect, diethylpropion>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of SPRYCEL and drugs that inhibit CYP3A4 (eg, ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, atazanavir, indinavir, nefazodone, nelfinavir, saquinavir, telithromycin) may increase exposure to dasatinib and should be avoided.

Output: <SPRYCEL, mechanism, ketoconazole>, <SPRYCEL, mechanism, itraconazole>, <SPRYCEL, mechanism, erythromycin>, <SPRYCEL, mechanism, clarithromycin>, <SPRYCEL, mechanism, ritonavir>, <SPRYCEL, mechanism, atazanavir>, <SPRYCEL, mechanism, indinavir>, <SPRYCEL, mechanism, nefazodone>, <SPRYCEL, mechanism, nelfinavir>, <SPRYCEL, mechanism, saquinavir>, <SPRYCEL, mechanism, telithromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Simultaneous administration of SPRYCEL with antacids should be avoided.

Output: <SPRYCEL, advise, antacids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If antacid therapy is needed, the antacid dose should be administered at least 2 hours prior to or 2 hours after the dose of SPRYCEL.

Output: <antacid, advise, SPRYCEL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: H2 Blockers/Proton Pump Inhibitors: Long-term suppression of gastric acid secretion by H2 blockers or proton pump inhibitors (eg, famotidine and omeprazole) is likely to reduce dasatinib exposure.

Output: <H2 blockers, effect, dasatinib>, <proton pump inhibitors, effect, dasatinib>, <famotidine, effect, dasatinib>, <omeprazole, effect, dasatinib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant use of H2 blockers or proton pump inhibitors with SPRYCEL is not recommended.

Output: <H2 blockers, advise, SPRYCEL>, <proton pump inhibitors, advise, SPRYCEL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The use of antacids should be considered in place of H2 blockers or proton pump inhibitors in patients receiving SPRYCEL therapy.

Output: <H2 blockers, advise, SPRYCEL>, <proton pump inhibitors, advise, SPRYCEL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, CYP3A4 substrates known to have a narrow therapeutic index such as alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ergot alkaloids (ergotamine, dihydroergotamine) should be administered with caution in patients receiving SPRYCEL.

Output: <alfentanil, advise, SPRYCEL>, <astemizole, advise, SPRYCEL>, <terfenadine, advise, SPRYCEL>, <cisapride, advise, SPRYCEL>, <cyclosporine, advise, SPRYCEL>, <fentanyl, advise, SPRYCEL>, <pimozide, advise, SPRYCEL>, <quinidine, advise, SPRYCEL>, <sirolimus, advise, SPRYCEL>, <tacrolimus, advise, SPRYCEL>, <ergot alkaloids, advise, SPRYCEL>, <ergotamine, advise, SPRYCEL>, <dihydroergotamine, advise, SPRYCEL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: After multiple dosing, interferon beta-1a (AVONEX  30 mcg IM once weekly) reduced TYSABRI  clearance by approximately 30%.

Output: <interferon beta-1a, mechanism, TYSABRI>, <AVONEX, mechanism, TYSABRI>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of terfenadine with Itraconazole has led to elevated plasma concentrations of terfenadine, resulting in rare instances of life- threatening cardiac dysrhythmias and one death.

Output: <terfenadine, mechanism, Itraconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Another oral azole antifungal, ketoconazole, inhibits the metabolism of astemizole, resulting in elevated plasma concentrations of astemizole and its active metabolite desmethylastermizole which may prolong QT intervals.

Output: <ketoconazole, mechanism, astemizole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In vitro data suggest that itraconazole, when compared to ketoconazole, has a less pronounced effect on the biotransformation system responsible for the metabolism of astemizole.

Output: <itraconazole, mechanism, astemizole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Based on the chemical resemblance of itraconazole and ketoconazole, coadministration of astemizole with itraconazole is contraindicated.

Output: <astemizole, advise, itraconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Human pharmacokinetics data indicate that oral ketoconazole potently inhibits the metabolism of cisapride resulting in an eight-fold increase in the mean AUC of cisapride.

Output: <ketoconazole, mechanism, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Data suggest that coadministration of oral ketoconazole and cisapride can result in prolongation of the QT interval on the ECG.

Output: <ketoconazole, effect, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In vitro data suggest that itraconazole also markedly inhibits the biotransformation system mainly responsible for the metabolism of cisapride;

Output: <itraconazole, mechanism, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: therefore concomitant administration of Itraconazole with cisapride is contraindicated.

Output: <Itraconazole, advise, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of Itraconazole with oral midazolam or triazolam has resulted in elevated plasma concentrations of the latter two drugs.

Output: <Itraconazole, mechanism, midazolam>, <Itraconazole, mechanism, triazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of Itraconazole and cyclosporine, tacrolimus or digoxin has led to increased plasma concentrations of the latter three drugs.

Output: <Itraconazole, mechanism, cyclosporine>, <Itraconazole, mechanism, tacrolimus>, <Itraconazole, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporine, tacrolimus and digoxin concentrations should be monitored at the initiation of Itraconazole therapy and frequently thereafter, and the dose of these three drug products adjusted appropriately.

Output: <Cyclosporine, advise, Itraconazole>, <tacrolimus, advise, Itraconazole>, <digoxin, advise, Itraconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rhabdomyolysis has been observed in patients receiving HMG-CoA reductase inhibitors administered alone (at recommended dosages) or concomitantly with immunosuppressive drugs including cyclosporine.

Output: <HMG-CoA reductase inhibitors, effect, immunosuppressive drugs>, <HMG-CoA reductase inhibitors, effect, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When Itraconazole was coadministered with phenytoin, rifampin, or H2antagonists, reduced plasma concentrations of itraconazole were reported.

Output: <Itraconazole, mechanism, phenytoin>, <Itraconazole, mechanism, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although no studies have been conducted, concomitant administration of Itraconazole and phenytoin may alter the metabolism of phenytoin;

Output: <Itraconazole, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: therefore, plasma concentrations of phenytoin should also be monitored when it is given concurrently with Itraconazole.

Output: <phenytoin, advise, Itraconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It has been reported that Itraconazole enhances the anticoagulant effect of coumarin-like drugs.

Output: <Itraconazole, effect, coumarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, prothrombin time should be carefully monitored in patients receiving Itraconazole and coumarin-like drugs simultaneously.

Output: <Itraconazole, advise, coumarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Plasma concentrations of azole antifungal agents are reduced when given concurrently with isoniazid.

Output: <azole antifungal agents, mechanism, isoniazid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Itraconazole plasma concentrations should be monitored when Itraconazole and isoniazid are coadministered.

Output: <Itraconazole, advise, isoniazid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Severe hypoglycemia has been reported in patients concomitantly receiving azole antifungal agents and oral hypoglycemic agents.

Output: <azole antifungal agents, effect, hypoglycemic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Blood glucose concentrations should be carefully monitored when Itraconazole and oral hypoglycemic agents are coadministered.

Output: <Itraconazole, advise, hypoglycemic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tinnitus and decreased hearing have been reported in patients concomitantly receiving Itraconazole and quinidine.

Output: <Itraconazole, effect, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Edema has been reported in patients concomitantly receiving Itraconazole and dihydropyridine calcium channel blockers.

Output: <Itraconazole, effect, dihydropyridine calcium channel blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tetracycline, a bacteriostatic antibiotic, may antagonize the bactercidal effect of penicillin and concurrent use of these drugs should be avoided.

Output: <Tetracycline, effect, penicillin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antibiotics: In vitro and/or in vivo data show that clarithromycin, erythromycin, and troleandomycin markedly inhibit the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG.

Output: <clarithromycin, mechanism, cisapride>, <erythromycin, mechanism, cisapride>, <troleandomycin, mechanism, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticholinergics: Concurrent administration of certain anticholinergic compounds, such as belladonna alkaloids and dicyclomine, would be expected to compromise the beneficial effects of cisapride.

Output: <anticholinergic compounds, effect, cisapride>, <belladonna alkaloids, effect, cisapride>, <dicyclomine, effect, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is advisable to check coagulation time within the first few days after the start and discontinuation of cisapride therapy, with an appropriate adjustment of the anticoagulant dose, if necessary.

Output: <cisapride, advise, anticoagulant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antidepressants: In vitro data indicate that nefazodone inhibits the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG.

Output: <nefazodone, mechanism, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antifungals: In vitro and/or in vivo data indicate that fluconazole, itraconazole, and oral ketoconazole markedly inhibit the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG.

Output: <fluconazole, mechanism, cisapride>, <itraconazole, mechanism, cisapride>, <ketoconazole, mechanism, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Human pharmacokinetic data indicate that oral ketoconazole markedly inhibits the metabolism of cisapride, resulting in a mean eight-fold increase in AUC of cisapride.

Output: <ketoconazole, mechanism, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A study in 14 normal male and female volunteers suggests that coadministration of cisapride and ketoconazole can result in prolongation of the QT interval on the ECG.

Output: <cisapride, effect, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: H2 Receptor Antagonists: Cimetidine coadministration leads to an increased peak plasma concentration and AUC of cisapride, there is no effect on cisapride absorption when it is coadministered with ranitidine.

Output: <Cimetidine, mechanism, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The gastrointestinal absorption of cimetidine and ranitidine is accelerated when they are coadministered with cisapride.

Output: <cimetidine, mechanism, cisapride>, <ranitidine, mechanism, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Protease Inhibitors: In vitro data indicate that indinavir and ritonavir markedly inhibit the metabolism of cisapride which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG.

Output: <indinavir, mechanism, cisapride>, <ritonavir, mechanism, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cisapride should not be used concomitantly with other drugs known to prolong the QT interval: certain antiarrhythmics, including those of Class IA (such as quinidine and procainamide) and Class III (such as sotalol);

Output: <Cisapride, advise, antiarrhythmics>, <Cisapride, advise, quinidine>, <Cisapride, advise, procainamide>, <Cisapride, advise, sotalol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chlorotrianisene may interact with antidepressants, aspirin, barbiturates, bromocriptine, calcium supplements, corticosteroids, corticotropin, cyclosporine, dantrolene, nicotine, somatropin, tamoxifen, and warfarin.

Output: <Chlorotrianisene, int, antidepressants>, <Chlorotrianisene, int, aspirin>, <Chlorotrianisene, int, barbiturates>, <Chlorotrianisene, int, bromocriptine>, <Chlorotrianisene, int, calcium>, <Chlorotrianisene, int, corticosteroids>, <Chlorotrianisene, int, corticotropin>, <Chlorotrianisene, int, cyclosporine>, <Chlorotrianisene, int, dantrolene>, <Chlorotrianisene, int, nicotine>, <Chlorotrianisene, int, somatropin>, <Chlorotrianisene, int, tamoxifen>, <Chlorotrianisene, int, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In combination with other central nervous system depressants, heroin may still kill even experienced users, particularly if their tolerance to the drug has reduced or the strength of their usual dose has increased.

Output: <central nervous system depressants, effect, heroin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Toxicology studies of heroin-related deaths reveal frequent involvement of other central nervous system depressants, including alcohol, benzodiazepines such as diazepam (Valium), and, to a rising degree, methadone.

Output: <heroin, effect, central nervous system depressants>, <heroin, effect, alcohol>, <heroin, effect, benzodiazepines>, <heroin, effect, diazepam>, <heroin, effect, Valium>, <heroin, effect, methadone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cocaine sometimes proves to be fatal when used in combination with heroin.

Output: <Cocaine, effect, heroin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Cholestyramine and colestipol resins: Cholestytamine and colestipol resins have the potential of binding thiazide diuretics and reducing diuretic absorption from the gastrointestinal tract

Output: <Cholestytamine, mechanism, thiazide diuretics>, <colestipol, mechanism, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Lithium: Generally should not be given with diuretics.

Output: <Lithium, advise, diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.

Output: <Diuretic agents, mechanism, lithium>, <Diuretic agents, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Refer to the package insert for lithium preparations before use of such preparations with chlorothiazide

Output: <lithium, advise, chlorothiazide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Non-steroidal Anti-inflammatory Drugs: In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.

Output: <non-steroidal anti-inflammatory agent, effect, loop diuretics>, <non-steroidal anti-inflammatory agent, effect, potassium-sparing diuretics>, <non-steroidal anti-inflammatory agent, effect, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, when chlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained

Output: <chlorothiazide, advise, non-steroidal anti-inflammatory agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Renal clearance measurements of PAH cannot be made with any significant accuracy in patients receiving sulfonamides, procaine, or thiazolesulfone.

Output: <PAH, effect, sulfonamides>, <PAH, effect, procaine>, <PAH, effect, thiazolesulfone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid depresses tubular secretion of certain weak acids such as PAH.

Output: <Probenecid, mechanism, PAH>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, patients receiving probenecid will have erroneously low ERPF and Tm PAH values.

Output: <probenecid, effect, PAH>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients on oral antidiabetic agents receiving VELCADE treatment may require close monitoring of their blood glucose levels and adjustment of the dose of their antidiabetic medication.

Output: <antidiabetic agents, advise, VELCADE>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antihistamines may enhance the effects of tricyclic antidepressants, barbiturates, alcohol, and other CNS depressants.

Output: <Antihistamines, effect, tricyclic antidepressants>, <Antihistamines, effect, barbiturates>, <Antihistamines, effect, alcohol>, <Antihistamines, effect, CNS depressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines.

Output: <MAO inhibitors, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sympathomimetic amines may reduce the antihypertensive effects of reserpine, veratrum alkaloids, methyldopa and mecamylamine.

Output: <Sympathomimetic amines, effect, reserpine>, <Sympathomimetic amines, effect, veratrum alkaloids>, <Sympathomimetic amines, effect, methyldopa>, <Sympathomimetic amines, effect, mecamylamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Effects of sympathomimetics are increased with MAO inhibitors and beta adrenergic blockers.

Output: <sympathomimetics, effect, MAO inhibitors>, <sympathomimetics, effect, beta adrenergic blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because of the danger of a potentially fatal prolongation of the QTc interval, halofantrine must not be given simultaneously with or subsequent to Mefloquine.

Output: <halofantrine, advise, Mefloquine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of Mefloquine and other related compounds (eg, quinine, quinidine and chloroquine) may produce electrocardiographic abnormalities and increase the risk of convulsions.

Output: <Mefloquine, effect, quinine>, <Mefloquine, effect, quinidine>, <Mefloquine, effect, chloroquine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This appears to be the only clinically relevant interaction of this kind with Mefloquine, although theoretically, coadministration of other drugs known to alter cardiac conduction (eg, anti-arrhythmic or beta-adrenergic blocking agents, calcium channel blockers, antihistamines or H1-blocking agents, tricyclic antidepressants and phenothiazines) might also contribute to a prolongation of the QTc interval.

Output: <Mefloquine, effect, anti-arrhythmic>, <Mefloquine, effect, beta-adrenergic blocking agents>, <Mefloquine, effect, calcium channel blockers>, <Mefloquine, effect, antihistamines>, <Mefloquine, effect, H1-blocking agents>, <Mefloquine, effect, tricyclic antidepressants>, <Mefloquine, effect, phenothiazines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients taking an anticonvulsant (eg, valproic acid, carbamazepine, phenobarbital or phenytoin), the concomitant use of Mefloquine may reduce seizure control by lowering the plasma levels of the anticonvulsant.

Output: <anticonvulsant, effect, Mefloquine>, <valproic acid, effect, Mefloquine>, <carbamazepine, effect, Mefloquine>, <phenobarbital, effect, Mefloquine>, <phenytoin, effect, Mefloquine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When Mefloquine is taken concurrently with oral live typhoid vaccines, attenuation of immunization cannot be excluded.

Output: <Mefloquine, effect, live typhoid vaccines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nevertheless, the effects of Mefloquine on travelers receiving comedication, particularly diabetics or patients using anticoagulants, should be checked before departure.

Output: <Mefloquine, advise, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.

Output: <Lithium, mechanism, diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: EDECRIN may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics.

Output: <EDECRIN, effect, aminoglycoside>, <EDECRIN, effect, cephalosporin antibiotics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein;

Output: <ethacrynic acid, mechanism, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In some patients, the administration of a non- steroidal antiinflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium- sparing and thiazide diuretics.

Output: <non- steroidal antiinflammatory agent, effect, loop diuretics>, <non- steroidal antiinflammatory agent, effect, potassium- sparing diuretics>, <non- steroidal antiinflammatory agent, effect, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, when EDECRIN and non- steroidal anti- inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

Output: <EDECRIN, effect, non- steroidal anti- inflammatory agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Non-selective MAO inhibitors including tranylcypromine sulfate, phenelzine sulfate, and pargyline HC1: Concomitant use of L-tyrosine and non-selective MAO inhibitors may cause hypertension.

Output: <L-tyrosine, effect, MAO inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Based on adult data, lower doses of caffeine may be needed following coadministration of drugs which are reported to decrease caffeine elimination (e.g., cimetidine and ketoconazole) and higher caffeine doses may be needed following coadministration of drugs that increase caffeine elimination (e.g., phenobarbital and phenytoin).

Output: <caffeine, advise, cimetidine>, <caffeine, advise, ketoconazole>, <caffeine, advise, phenobarbital>, <caffeine, advise, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caffeine administered concurrently with ketoprofen reduced the urine volume in 4 healthy volunteers.

Output: <Caffeine, effect, ketoprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Auranofin should be avoided by patients with a history of serious reaction to any gold medication, including Solganal and Myochrysine.

Output: <Auranofin, advise, gold medication>, <Auranofin, advise, Solganal>, <Auranofin, advise, Myochrysine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Auranofin should not be used together with penicillamine (Depen, Cuprimine), another arthritis medication.

Output: <Auranofin, advise, penicillamine>, <Auranofin, advise, Depen>, <Auranofin, advise, Cuprimine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The in vitro interaction between nevirapine and the antithrombotic agent warfarin is complex.

Output: <nevirapine, int, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When warfarin is co-administered with nevirapine, anticoagulation levels should be monitored frequently.

Output: <warfarin, advise, nevirapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Clarithromycin exposure was significantly decreased by nevirapine;

Output: <Clarithromycin, mechanism, nevirapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oral contraceptives and other hormonalmethods of birth control should not be usedas the sole method of contraception inwomen taking nevirapine, since nevirapinemay lower the plasma levels of thesemedications.

Output: <contraceptives, advise, nevirapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nevirapine and ketoconazole should not beadministered concomitantly becausedecreases in ketoconazole plasmaconcentrations may reduce the efficacy of the drug.

Output: <Nevirapine, advise, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A dose increase of lopinavir/ritonavir to 533/133 mg twice daily with food isrecommended in combination with nevirapine.

Output: <lopinavir, advise, nevirapine>, <ritonavir, advise, nevirapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methadone levels may be decreased; increased dosages may be required to prevent symptoms of opiate withdrawal. Methadone maintained patients beginning nevirapine therapy should be monitored forevidence of withdrawal and methadone dose should be adjusted accordingly.

Output: <Methadone, advise, nevirapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nevirapine and rifampin should not beadministered concomitantly becausedecreases in nevirapine plasmaconcentrations may reduce the efficacy ofthe drug.

Output: <Nevirapine, advise, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: aBased on reports of narcotic withdrawal syndrome in patients treated with nevirapine and methadone concurrently, and evidence of decreased plasma concentrations of methadone.

Output: <nevirapine, effect, methadone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: In healthy subjects receiving ketoconazole, a CYP3A4 inhibitor, at 200 mg twice daily for 7 days, systemic exposure (AUC) to lapatinib was increased to approximately 3.6-fold of control and half-life increased to 1.7-fold of control.

Output: <ketoconazole, mechanism, lapatinib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Carbamazepine: In healthy subjects receiving the CYP3A4 inducer, carbamazepine, at 100 mg twice daily for 3 days and 200 mg twice daily for 17 days, systemic exposure (AUC) to lapatinib was decreased approximately 72%.

Output: <carbamazepine, mechanism, lapatinib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: MAO inhibitors should be used with caution in patients receiving hydralazine.

Output: <MAO inhibitors, advise, hydralazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When other potent parental antihypertensive drugs, such as diazoxide, are used in combination with hydralazine, patients should be continuously observed for several hours for any excessive fall in blood pressure.

Output: <antihypertensive drugs, effect, diazoxide>, <antihypertensive drugs, effect, hydralazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Profound hypotensive episodes may occur when diazoxide infection and hydralazine are used concomitantly.

Output: <diazoxide, effect, hydralazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Propranolol increases hydralazines serum concentrations.

Output: <Propranolol, mechanism, hydralazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: NSAIDs may decrease the hemodynamic effects of hydralazine;

Output: <NSAIDs, effect, hydralazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, because bleeding has been reported when ibuprofen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen to patients on anticoagulants.

Output: <ibuprofen, effect, coumarin-type anticoagulants>, <nonsteroidal anti-inflammatory agents, effect, coumarin-type anticoagulants>, <ibuprofen, advise, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including ibuprofen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug.

Output: <aspirin, effect, nonsteroidal anti-inflammatory agents>, <aspirin, effect, ibuprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methotrexate: Ibuprofen, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices.

Output: <Ibuprofen, mechanism, methotrexate>, <nonsteroidal anti-inflammatory drugs, mechanism, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This may indicate that ibuprofen could enhance the toxicity of methotrexate.

Output: <ibuprofen, effect, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be used if ibuprofen is administered concomitantly with methotrexate.

Output: <ibuprofen, advise, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide: Clinical studies, as well as random observations, have shown that ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients.

Output: <ibuprofen, effect, furosemide>, <ibuprofen, effect, thiazides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: Ibuprofen produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers.

Output: <Ibuprofen, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Output: <ibuprofen, advise, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Carbamazepine: Elevated carbamazepine levels have been reported in postmarketing experience when SUPRAX is administered concomitantly.

Output: <carbamazepine, mechanism, SUPRAX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin and Anticoagulants: Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly.

Output: <Warfarin, effect, cefixime>, <Anticoagulants, effect, cefixime>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine: Cimetidine increases nicardipine HCl plasma levels.

Output: <Cimetidine, mechanism, nicardipine HCl>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digoxin: Some calcium blockers may increase the concentration of digitalis preparations in the blood.

Output: <calcium blockers, mechanism, digitalis preparations>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nicardipine HCl usually does not alter the plasma levels of digoxin, however, serum digoxin levels should be evaluated after concomitant therapy with nicardipine HCl is initiated.

Output: <digoxin, advise, nicardipine HCl>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Plasma concentrations of cyclosporine should therefore be closely monitored, and its dosage reduced accordingly, in patients treated with nicardipine.

Output: <cyclosporine, advise, nicardipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients treated with proton pump inhibitors and warfarin concomitantly may need to be monitored for increases in INR and prothrombin time.

Output: <proton pump inhibitors, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of esomeprazole 30 mg and diazepam, a CYP2C19 substrate, resulted in a 45% decrease in clearance of diazepam.

Output: <esomeprazole, mechanism, diazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg, ketoconazole, iron salts and digoxin).

Output: <esomeprazole, mechanism, ketoconazole>, <esomeprazole, mechanism, iron>, <esomeprazole, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of clarithromycin with pimozide is contraindicated.

Output: <clarithromycin, advise, pimozide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: Concomitant administration of diclofenac and aspirin is not recommended because diclofenac is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels, and AUC values.

Output: <diclofenac, advise, aspirin>, <diclofenac, mechanism, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticoagulants: While studies have not shown diclofenac to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs.

Output: <diclofenac, advise, NSAIDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because prostaglandins play an important role in hemostasis, and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including diclofenac, and warfarin requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.

Output: <NSAIDs, advise, warfarin>, <diclofenac, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ingestion of diclofenac may increase serum concentrations of digoxin and methotrexate and increase cyclosporine s nephrotoxicity.

Output: <diclofenac, mechanism, digoxin>, <diclofenac, mechanism, methotrexate>, <diclofenac, effect, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients who begin taking diclofenac or who increase their diclofenac dose or any other NSAID while taking digoxin, methotrexate, or cyclosporine may develop toxicity characteristics for these drugs.

Output: <diclofenac, effect, digoxin>, <diclofenac, effect, methotrexate>, <diclofenac, effect, cyclosporine>, <NSAID, effect, digoxin>, <NSAID, effect, methotrexate>, <NSAID, effect, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: Diclofenac decreases lithium renal clearance and increases lithium plasma levels.

Output: <Diclofenac, mechanism, lithium>, <Diclofenac, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients taking diclofenac and lithium concomitantly, lithium toxicity may develop.

Output: <diclofenac, effect, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of diclofenac that necessitated changes in the doses of such agents.

Output: <insulin, effect, diclofenac>, <hypoglycemic agents, effect, diclofenac>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A direct causal relationship has not been established, but physicians should consider the possibility that diclofenac may alter a diabetic patient s response to insulin or oral hypoglycemic agents.

Output: <diclofenac, effect, insulin>, <diclofenac, effect, hypoglycemic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diuretics: Diclofenac and other NSAIDs can inhibit the activity of diuretics.

Output: <Diclofenac, effect, diuretics>, <NSAIDs, effect, diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of diclofenac therapy.

Output: <phenobarbital, effect, diclofenac>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Protein Binding In vitro, diclofenac interferes minimally or not at all with the protein binding of salicylic acid (20% decrease in binding), tolbutamide, prednisolone (10% decrease in binding), or warfarin.

Output: <diclofenac, mechanism, salicylic acid>, <diclofenac, mechanism, tolbutamide>, <diclofenac, mechanism, prednisolone>, <diclofenac, mechanism, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Renal function should be monitored carefully if high doses of aminoglycosides are to be administered with MAXIPIME because of the increased potential of nephrotoxicity and ototoxicity of aminoglycoside antibiotics.

Output: <aminoglycosides, advise, MAXIPIME>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nephrotoxicity has been reported following concomitant administration of other cephalosporins with potent diuretics such as furosemide.

Output: <cephalosporins, effect, diuretics>, <cephalosporins, effect, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Potassium-depleting diuretics are a major contributing factor to digitalis toxicity.

Output: <Potassium-depleting diuretics, effect, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, and spironolactone raise the serum digoxin concentration due to a reduction in clearance and/or in volume of distribution of the drug, with the implication that digitalis intoxication may result.

Output: <Quinidine, mechanism, digoxin>, <verapamil, mechanism, digoxin>, <amiodarone, mechanism, digoxin>, <propafenone, mechanism, digoxin>, <indomethacin, mechanism, digoxin>, <itraconazole, mechanism, digoxin>, <alprazolam, mechanism, digoxin>, <spironolactone, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Erythromycin and clarithromycin (and possibly other macrolide antibiotics) and tetracycline may increase digoxin absorption in patients who inactivate digoxin by bacterial metabolism in the lower intestine, so that digitalis intoxication may result.

Output: <Erythromycin, mechanism, digoxin>, <clarithromycin, mechanism, digoxin>, <macrolide antibiotics, mechanism, digoxin>, <tetracycline, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Propantheline and diphenoxylate, by decreasing gut motility, may increase digoxin absorption.

Output: <Propantheline, mechanism, digoxin>, <diphenoxylate, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids, kaolin-pectin, sulfasalazine, neomycin, cholestyramine, certain anticancer drugs, and metoclopramide may interfere with intestinal digoxin absorption, resulting in unexpectedly low serum concentrations.

Output: <Antacids, mechanism, digoxin>, <kaolin, mechanism, digoxin>, <sulfasalazine, mechanism, digoxin>, <neomycin, mechanism, digoxin>, <cholestyramine, mechanism, digoxin>, <metoclopramide, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rifampin may decrease serum digoxin concentration, especially in patients with renal dysfunction, by increasing the non-renal clearance of digoxin.

Output: <Rifampin, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thyroid administration to a digitalized, hypothyroid patient may increase the dose requirement of digoxin.

Output: <Thyroid, advise, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of digoxin and sympathomimetics increases the risk of cardiac arrhythmias.

Output: <digoxin, effect, sympathomimetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although beta-adrenergic blockers or calcium channel blockers and digoxin may be useful in combination to control atrial fibrillation, their additive effects on AV node conduction can result in advanced or complete heart block.

Output: <beta-adrenergic blockers, effect, digoxin>, <calcium channel blockers, effect, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a multiple dose study of theophylline (400 mg once daily for 3 days) and cetirizine (20 mg once daily for 3 days), a 16% decrease in the clearance of cetirizine was observed.

Output: <theophylline, mechanism, cetirizine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There was a small decrease in the clearance of cetirizine caused by a 400-mg dose of theophylline;

Output: <cetirizine, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Preliminary data which suggest that dapsone may inhibit the anti-inflammatory activity of Lamprene have not been confirmed.

Output: <dapsone, effect, Lamprene>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If leprosy-associated inflammatory reactions develop in patients being treated with dapsone and clofazimine, it is still advisable to continue treatment with both drugs.

Output: <dapsone, advise, clofazimine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenothiazines - Taking piperazine and a phenothiazine together may increase the risk of convulsions (seizures).

Output: <piperazine, effect, phenothiazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pyrantel (e.g., Antiminth) - Taking piperazine and pyrantel together may decrease the effects of piperazine.

Output: <piperazine, effect, pyrantel>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diphenhydramine hydrochloride has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc).

Output: <Diphenhydramine hydrochloride, effect, alcohol>, <Diphenhydramine hydrochloride, effect, CNS depressants>, <Diphenhydramine hydrochloride, effect, hypnotics>, <Diphenhydramine hydrochloride, effect, sedatives>, <Diphenhydramine hydrochloride, effect, tranquilizers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines.

Output: <MAO inhibitors, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be exercised when anticoagulants are given in conjunction with Atromid-S.

Output: <anticoagulants, advise, Atromid-S>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Atromid-S may displace acidic drugs such as phenytoin or tolbutamide from their binding sites.

Output: <Atromid-S, mechanism, phenytoin>, <Atromid-S, mechanism, tolbutamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The hypoglycemic effect of tolbutamide has been reported to increase when Atromid-S is given concurrently.

Output: <tolbutamide, effect, Atromid-S>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Fulminant rhabdomyolysis has been seen as early as three weeks after initiation of combined therapy with another fibrate and lovastatin but may be seen after several months.

Output: <fibrate, effect, lovastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: For these reasons, it is felt that, in most subjects who have had an unsatisfactory lipid response to either drug alone, the possible benefits of combined therapy with lovastatin and a fibrate do not outweigh the risks of severe myopathy, rhabdomyolysis, and acute renal failure.

Output: <lovastatin, effect, fibrate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, the combined use of lovastatin with fibrates should generally be avoided.

Output: <lovastatin, advise, fibrates>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Treatment with PEGASYS once weekly for 4 weeks in healthy subjects was associated with an inhibition of P450 1A2 and a 25% increase in theophylline AUC.

Output: <PEGASYS, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Theophylline serum levels should be monitored and appropriate dose adjustments considered for patients given both theophylline and PEGASYS.

Output: <theophylline, advise, PEGASYS>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nucleoside Analogues Didanosine Co-administration of COPEGUS and didanosine is not recommended.

Output: <COPEGUS, advise, didanosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Stavudine and Zidovudine Ribavirin can antagonize the in vitro antiviral activity of stavudine and zidovudine against HIV.

Output: <Ribavirin, effect, stavudine>, <Ribavirin, effect, zidovudine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The adverse effects of CAMPTOSAR, such as myelosuppression and diarrhea, would be expected to be exacerbated by other antineoplastic agents having similar adverse effects.

Output: <CAMPTOSAR, effect, antineoplastic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lymphocytopenia has been reported in patients receiving CAMPTOSAR, and it is possible that the administration of dexamethasone as antiemetic prophylaxis may have enhanced the likelihood of this effect.

Output: <CAMPTOSAR, effect, dexamethasone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The incidence of akathisia in clinical trials of the weekly dosage schedule was greater (8.5%, 4/47 patients) when prochlorperazine was administered on the same day as CAMPTOSAR than when these drugs were given on separate days (1.3%, 1/80 patients).

Output: <prochlorperazine, effect, CAMPTOSAR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It would be expected that laxative use during therapy with CAMPTOSAR would worsen the incidence or severity of diarrhea, but this has not been studied.

Output: <laxative, effect, CAMPTOSAR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In view of the potential risk of dehydration secondary to vomiting and/or diarrhea induced by CAMPTOSAR, the physician may wish to withhold diuretics during dosing with CAMPTOSAR and, certainly, during periods of active vomiting or diarrhea.

Output: <diuretics, effect, CAMPTOSAR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent administration of etanercept (another TNF -blocking agent) and anakinra (an interleukin-1 antagonist) has been associated with an increased risk of serious infections, and increased risk of neutropenia and no additional benefit compared to these medicinal products alone.

Output: <etanercept, effect, anakinra>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other TNFa-blocking agents (including REMICADE) used in combination with anakinra may also result in similar toxicities.

Output: <TNFa-blocking agents, effect, anakinra>, <REMICADE, effect, anakinra>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although acid-base and electrolyte disturbances were not reported in the clinical trials with dorzolamide, these disturbances have been reported with oral carbonic anhydrase inhibitors and have, in some instances, resulted in drug interactions (e.g., toxicity associated with high-dose salicylate therapy).

Output: <dorzolamide, effect, carbonic anhydrase inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Mercaptopurine/Azathioprine: Allopurinol inhibits the enzymatic oxidation of mercaptopurine and azathioprine to 6-thiouric acid.

Output: <Allopurinol, mechanism, mercaptopurine>, <Allopurinol, mechanism, azathioprine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients receiving mercaptopurine (Purinethol) or azathioprine (Imuran), the concomitant administration of 300-600 mg of allopurinol per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine.

Output: <allopurinol, advise, mercaptopurine>, <allopurinol, advise, azathioprine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dicumarol: It has been reported that allopurinol prolongs the half-life of the anticoagulant, dicumarol.

Output: <allopurinol, mechanism, dicumarol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Uricosuric Agents: Since the excretion of oxipurinol is similar to that of urate, uricosuric agents, which increase the excretion of urate, are also likely to increase the excretion of oxipurinol and thus lower the degree of inhibition of xanthine oxidase.

Output: <uricosuric agents, mechanism, oxipurinol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant administration of uricosuric agents and allopurinol has been associated with a decrease in the excretion of oxypurines (hypoxanthine and xanthine) and an increase in urinary uric acid excretion compared with that observed with allopurinol alone.

Output: <uricosuric agents, mechanism, allopurinol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thiazide Diuretics: The reports that the concomitant use of allopurinol and thiazide diuretics may contribute to the enhancement of allopurinol toxicity in some patients have been reviewed in an attempt to establish a cause-and-effect relationship and a mechanism of causation.

Output: <allopurinol, effect, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although a causal mechanism and a cause-and-effect relationship have not been established, current evidence suggests that renal function should be monitored in patients on thiazide diuretics and allopurinol even in the absence of renal failure, and dosage levels should be even more conservatively adjusted in those patients on such combined therapy if diminished renal function is detected..

Output: <thiazide diuretics, advise, allopurinol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ampicillin/Amoxicillin: An increase in the frequency of skin rash has been reported among patients receiving ampicillin or amoxicillin concurrently with allopurinol compared to patients who are not receiving both drugs.

Output: <ampicillin, effect, allopurinol>, <amoxicillin, effect, allopurinol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cytotoxic Agents: Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic disease, except leukemia, in the presence of allopurinol.

Output: <cyclophosphamide, effect, allopurinol>, <cytotoxic agents, effect, allopurinol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chlorpropamide: Chlorpropamides plasma half-life may be prolonged by allopurinol, since allopurinol and chlorpropamide may compete for excretion in the renal tubule.

Output: <Chlorpropamide, mechanism, allopurinol>, <allopurinol, mechanism, chlorpropamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The risk of hypoglycemia secondary to this mechanism may be increased if allopurinol and chlorpropamide are given concomitantly in the presence of renal insufficiency.

Output: <allopurinol, effect, chlorpropamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporin: Reports indicate that cyclosporine levels may be increased during concomitant treatment with allopurinol sodium for injection.

Output: <cyclosporine, mechanism, allopurinol sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Catecholamine-depleting drugs, such as reserpine, may have an additive effect when given with beta-blocking agents.

Output: <Catecholamine-depleting drugs, effect, beta-blocking agents>, <reserpine, effect, beta-blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients treated with acebutolol plus catecholamine depletors should, therefore, be observed closely for evidence of marked bradycardia or hypotension which may present as vertigo, syncope/presyncope, or orthostatic changes in blood pressure without compensatory tachycardia.

Output: <acebutolol, advise, catecholamine depletors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Exaggerated hypertensive responses have been reported from the combined use of beta-adrenergic antagonists and alpha-adrenergic stimulants, including those contained in proprietary cold remedies and vasoconstrictive nasal drops.

Output: <beta-adrenergic antagonists, effect, alpha-adrenergic stimulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by nonsteroidal anti-inflammatory drugs has been reported.

Output: <beta-adrenoceptor blocking agents, effect, nonsteroidal anti-inflammatory drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: These antibiotics should be used in the myasthenic patient only where definitely indicated, and then careful adjustment should be made of adjunctive anticholinesterase dosage.

Output: <antibiotics, advise, anticholinesterase>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Betaseron administration to three cancer patients over a dose range of 0.025 mg to 2.2 mg led to a dose-dependent inhibition of antipyrine elimination.14 The effect of alternate-day administration of 0.25 mg of Betaseron on drug metabolism in MS patients is unknown.

Output: <Betaseron, mechanism, antipyrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aminoglycosides: The mixing of piperacillin with an aminoglycoside in vitro can result in substantial inactivation of the aminoglycoside.

Output: <piperacillin, effect, aminoglycoside>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Vecuronium: When used in the perioperative period, piperacillin has been implicated in the prolongation of the neuromuscular blockade of vecuronium.

Output: <piperacillin, effect, vecuronium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In one controlled clinical study, the ureidopenicillins, including piperacillin, were reported to prolong the action of vecuronium.

Output: <piperacillin, effect, vecuronium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Due to their similar mechanism of action, it is expected that the neuromuscular blockade produced by any of the non-depolarizing muscle relaxants could be prolonged in the presence of piperacillin.

Output: <non-depolarizing muscle relaxants, effect, piperacillin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid: The oral combination of probenecid before intramuscular injection of PIPRACIL produces an increase in piperacillin peak serum level of about 30%.

Output: <probenecid, mechanism, PIPRACIL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methotrexate: Piperacillin sodium may reduce the excretion of methotrexate.

Output: <Piperacillin sodium, mechanism, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta-blockers, clonidine, lithium salts, and alcohol may either potentiate or weaken the blood-glucose-lowering effect of insulin.

Output: <Beta-blockers, effect, insulin>, <clonidine, effect, insulin>, <lithium, effect, insulin>, <alcohol, effect, insulin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The action of the benzodiazepines may be potentiated by anticonvulsants, antihistamines, alcohol, barbiturates, monoamine oxidase inhibitors, narcotics, phenothiazines, psychotropic medications, or other drugs that produce CNS depression.

Output: <benzodiazepines, effect, anticonvulsants>, <benzodiazepines, effect, antihistamines>, <benzodiazepines, effect, alcohol>, <benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, monoamine oxidase inhibitors>, <benzodiazepines, effect, narcotics>, <benzodiazepines, effect, phenothiazines>, <benzodiazepines, effect, psychotropic medications>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: While no in vivo drug-drug interaction studies were conducted between estazolam and inducers of CYP3A, compounds that are potent CYP3A inducers (such as carbamazepine, phenytoin, rifampin, and barbiturates) would be expected to decrease estazolam concentrations.

Output: <estazolam, mechanism, carbamazepine>, <estazolam, mechanism, phenytoin>, <estazolam, mechanism, rifampin>, <estazolam, mechanism, barbiturates>, <estazolam, mechanism, estazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Consequently, estazolam should be avoided in patients receiving ketoconazole and itraconazole, which are very potent inhibitors of CYP3A.

Output: <estazolam, advise, ketoconazole>, <estazolam, advise, itraconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The following are examples of drugs known to inhibit the metabolism of other related benzodiazepines, presumably through inhibition of CYP3A: nefazodone, fluvoxamine, cimetidine, diltiazem, isoniazide, and some macrolide antibiotics.

Output: <benzodiazepines, mechanism, nefazodone>, <benzodiazepines, mechanism, fluvoxamine>, <benzodiazepines, mechanism, cimetidine>, <benzodiazepines, mechanism, diltiazem>, <benzodiazepines, mechanism, isoniazide>, <benzodiazepines, mechanism, macrolide antibiotics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ethopropazine may interact with alcohol or other CNS depressants, causing increased sedative effects.

Output: <Ethopropazine, effect, alcohol>, <Ethopropazine, effect, CNS depressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ethopropazine can interact with chlorpromazine, increasing the metabolism of chlorpromazine.

Output: <Ethopropazine, mechanism, chlorpromazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Catecholamine-depleting drugs, e.g., reserpine, may have an additive effect when given with beta blocking agents.

Output: <reserpine, effect, beta blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: BREVIBLOC concentrations were equivocally higher when given with warfarin, but this is not likely to be clinically important.

Output: <BREVIBLOC, mechanism, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When digoxin and BREVIBLOC were concomitantly administered intravenously to normal volunteers, there was a 10-20% increase in digoxin blood levels at some time points.

Output: <digoxin, mechanism, BREVIBLOC>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When intravenous morphine and BREVIBLOC were concomitantly administered in normal subjects, no effect on morphine blood levels was seen, but BREVIBLOC steady-state blood levels were increased by 46% in the presence of morphine.

Output: <BREVIBLOC, mechanism, morphine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The onset of neuromuscular blockade by succinylcholine was unaffected by BREVIBLOC, but the duration of neuromuscular blockade was prolonged from 5 minutes to 8 minutes.

Output: <succinylcholine, effect, BREVIBLOC>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although the interactions observed in these studies do not appear to be of major clinical importance, BREVIBLOC should be titrated with caution in patients being treated concurrently with digoxin, morphine, succinylcholine or warfarin.

Output: <BREVIBLOC, advise, digoxin>, <BREVIBLOC, advise, morphine>, <BREVIBLOC, advise, succinylcholine>, <BREVIBLOC, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be exercised when considering the use of BREVIBLOC and verapamil in patients with depressed myocardial function.

Output: <BREVIBLOC, advise, verapamil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Additionally, BREVIBLOC should not be used to control supraventricular tachycardia in the presence of agents which are vasoconstrictive and inotropic such as dopamine, epinephrine, and norepinephrine because of the danger of blocking cardiac contractility when systemic vascular resistance is high.

Output: <BREVIBLOC, advise, dopamine>, <BREVIBLOC, advise, epinephrine>, <BREVIBLOC, advise, norepinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drug-Drug Interactions Albuterol - STRATTERA should be administered with caution to patients being treated with systemically-administered (oral or intravenous) albuterol (or other beta2 agonists) because the action of albuterol on the cardiovascular system can be potentiated resulting in increases in heart rate and blood pressure.

Output: <STRATTERA, advise, albuterol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dosage adjustment of STRATTERA may be necessary when coadministered with CYP2D6 inhibitors, e.g., paroxetine, fluoxetine, and quinidine.

Output: <STRATTERA, advise, paroxetine>, <STRATTERA, advise, fluoxetine>, <STRATTERA, advise, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In EM individuals treated with paroxetine or fluoxetine, the AUC of atomoxetine is approximately 6- to 8-fold and Css,max is about 3- to 4-fold greater than atomoxetine alone.

Output: <paroxetine, mechanism, atomoxetine>, <fluoxetine, mechanism, atomoxetine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Possible drug interactions of HUMORSOL with succinylcholine or with other anticholinesterase agents.

Output: <HUMORSOL, int, succinylcholine>, <HUMORSOL, int, anticholinesterase agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When you are using idoxuridine, it is especially important that your health care professional know if you are using the following: Eye product containing boric acid.

Output: <idoxuridine, advise, boric acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Boric acid may interact with the idoxuridine preparation causing a gritty substance to form or may interact with the preservative in the idoxuridine preparation causing a toxic effect in the eye.

Output: <Boric acid, mechanism, idoxuridine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of nelfinavir at steady-state with a single dose of azithromycin (2 x 600 mg tablets) results in increased azithromycin serum concentrations.

Output: <nelfinavir, effect, azithromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although a dose adjustment of azithromycin is not recommended when administered in combination with nelfinavir, close monitoring for known side effects of azithromycin, such as liver enzyme abnormalities and hearing impairment, is warranted.

Output: <azithromycin, advise, nelfinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, prudent medical practice dictates careful monitoring of prothrombin time in all patients treated with azithromycin and warfarin concomitantly.

Output: <azithromycin, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent use of macrolides and warfarin in clinical practice has been associated with increased anticoagulant effects.

Output: <macrolides, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When used in therapeutic doses, azithromycin had a modest effect on the pharmacokinetics of atorvastatin, carbamazepine, cetirizine, didanosine, efavirenz, fluconazole, indinavir, midazolam, rifabutin, sildenafil, theophylline (intravenous and oral), triazolam, trimethoprim/sulfamethoxazole or zidovudine.

Output: <azithromycin, mechanism, atorvastatin>, <azithromycin, mechanism, carbamazepine>, <azithromycin, mechanism, cetirizine>, <azithromycin, mechanism, didanosine>, <azithromycin, mechanism, efavirenz>, <azithromycin, mechanism, fluconazole>, <azithromycin, mechanism, indinavir>, <azithromycin, mechanism, midazolam>, <azithromycin, mechanism, rifabutin>, <azithromycin, mechanism, sildenafil>, <azithromycin, mechanism, theophylline>, <azithromycin, mechanism, triazolam>, <azithromycin, mechanism, trimethoprim>, <azithromycin, mechanism, sulfamethoxazole>, <azithromycin, mechanism, zidovudine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration with efavirenz or fluconazole had a modest effect on the pharmacokinetics of azithromycin.

Output: <efavirenz, mechanism, azithromycin>, <fluconazole, mechanism, azithromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of probenecid with acyclovir has been shown to increase the mean half-life and the area under the concentration-time curve.

Output: <probenecid, mechanism, acyclovir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rifampin, an inducer of drug metabolism, decreased the concentrations of losartan and its active metabolite.

Output: <Rifampin, mechanism, losartan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Fluconazole, an inhibitor of P450 2C9, decreased active metabolite concentration and increased losartan concentration.

Output: <Fluconazole, mechanism, losartan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: As with other antihypertensive agents, the antihypertensive effect of losartan may be blunted by the non-steroidal anti-inflammatory drug indomethacin

Output: <losartan, effect, indomethacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators.

Output: <isosorbide mononitrate, effect, vasodilators>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination.

Output: <calcium channel blockers, effect, organic nitrates>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels.

Output: <Probenecid, mechanism, cephalosporins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Levothyroxine Sodium Absorption: The following agents may bind and decrease absorption of levothyroxine sodium from the gastrointestinal tract: aluminum hydoxide, cholestyramine resin, colestipol hydrochloride, ferrous sulfate, sodium polystyrene sulfonate, soybean flour (e.g., infant formula), sucralfate.

Output: <levothyroxine sodium, mechanism, aluminum hydoxide>, <levothyroxine sodium, mechanism, cholestyramine>, <levothyroxine sodium, mechanism, colestipol hydrochloride>, <levothyroxine sodium, mechanism, ferrous sulfate>, <levothyroxine sodium, mechanism, sodium polystyrene sulfonate>, <levothyroxine sodium, mechanism, sucralfate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Binding to Serum Proteins: The following agents may either inhibit levothyroxine sodium binding to serum proteins or alter the concentrations of serum binding proteins: androgens and related anabolic hormones, asparaginase, clofibrate, estrogens and estrogen-containing compounds, 5-fluorouracil, furosemide, glucocorticoids, meclofenamic acid, mefenamic acid, methadone, perphenazine, phenylbutazone, phenytoin, salicylates, tamoxifen.

Output: <levothyroxine sodium, mechanism, androgens>, <levothyroxine sodium, mechanism, anabolic hormones>, <levothyroxine sodium, mechanism, asparaginase>, <levothyroxine sodium, mechanism, clofibrate>, <levothyroxine sodium, mechanism, estrogens>, <levothyroxine sodium, mechanism, estrogen-containing compounds>, <levothyroxine sodium, mechanism, 5-fluorouracil>, <levothyroxine sodium, mechanism, furosemide>, <levothyroxine sodium, mechanism, glucocorticoids>, <levothyroxine sodium, mechanism, meclofenamic acid>, <levothyroxine sodium, mechanism, mefenamic acid>, <levothyroxine sodium, mechanism, methadone>, <levothyroxine sodium, mechanism, perphenazine>, <levothyroxine sodium, mechanism, phenylbutazone>, <levothyroxine sodium, mechanism, phenytoin>, <levothyroxine sodium, mechanism, salicylates>, <levothyroxine sodium, mechanism, tamoxifen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketamine: Marked hypertension and tachycardia have been reported in association with concomitant administration of levothyroxine sodium and ketamine.

Output: <levothyroxine sodium, effect, ketamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids and sucralfate: Sucralfate and antacids containing magnesium or aluminum, as well as formulations containing divalent and trivalent cations such as Videx  (didanosine), chewable/buffered tablets or the pediatric powder for oral solution can form chelation complexes with lomefloxacin and interfere with its bioavailability.

Output: <Sucralfate, mechanism, lomefloxacin>, <magnesium, mechanism, lomefloxacin>, <aluminum, mechanism, lomefloxacin>, <Videx, mechanism, lomefloxacin>, <didanosine, mechanism, lomefloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sucralfate administered 2 hours before lomefloxacin resulted in a slower absorption (mean C max decreased by 30% and mean T max increased by 1 hour) and a lesser extent of absorption (mean AUC decreased by approximately 25%).

Output: <Sucralfate, mechanism, lomefloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Magnesium- and aluminum-containing antacids, administered concomitantly with lomefloxacin, significantly decreased the bioavailability (48%) of lomefloxacin.

Output: <Magnesium, mechanism, lomefloxacin>, <aluminum, mechanism, lomefloxacin>, <antacids, mechanism, lomefloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Separating the doses of antacid and lomefloxacin minimizes this decrease in bioavailability;

Output: <antacid, mechanism, lomefloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other quinolones have demonstrated moderate to marked interference with the metabolism of caffeine, resulting in a reduced clearance, a prolongation of plasma half-life, and an increase in symptoms that accompany high levels of caffeine.

Output: <quinolones, mechanism, caffeine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine: Cimetidine has been demonstrated to interfere with the elimination of other quinolones.

Output: <Cimetidine, mechanism, quinolones>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporine: Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with other members of the quinolone class.

Output: <cyclosporine, mechanism, quinolone class>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin: Quinolones may enhance the effects of the oral anticoagulant, warfarin, or its derivatives.

Output: <Quinolones, effect, anticoagulant>, <Quinolones, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aprepitant has been shown to induce the metabolism of S(-) warfarin and tolbutamide, which are metabolized through CYP2C9.

Output: <Aprepitant, mechanism, S(-) warfarin>, <Aprepitant, mechanism, tolbutamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of Aprepitant with these drugs or other drugs that are known to be metabolized by CYP2C9, such as phenytoin, may result in lower plasma concentrations of these drugs.

Output: <Aprepitant, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticosteroids: Dexamethasone: Aprepitant, when given as a regimen of 125mg with dexamethasone coadministered orally as 20 mg on Day 1, and Aprepitant when given as 80 mg/day with dexamethasone coadministered orally as 8 mg on Days 2 through 5, increased the AUC of dexamethasone, a CYP3A4 substrate by 2.2-fold, on Days 1 and 5.

Output: <Aprepitant, mechanism, dexamethasone>, <Aprepitant, mechanism, dexamethasone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The oral dexamethasone doses should be reduced by approximately 50% when coadministered with Aprepitant, to achieve exposures of dexamethasone similar to those obtained when it is given without Aprepitant.

Output: <dexamethasone, advise, Aprepitant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The daily dose of dexamethasone administered in clinical studies with Aprepitant reflects an approximate 50% reduction of the dose of dexamethasone.

Output: <dexamethasone, mechanism, Aprepitant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aprepitant, when given as a regimen of 125 mg on Day 1 and 80 mg/day on Days 2 and 3, increased the AUC of methylprednisolone, a CYP3A4 substrate, by 1.34-fold on Day 1 and by 2.5-fold on Day 3, when methylprednisolone was coadministered intravenously as 125 mg on Day 1 and orally as 40 mg on Days 2 and 3.

Output: <Aprepitant, mechanism, methylprednisolone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The IV methylprednisolone dose should be reduced by approximately 25%, and the oral methylprednisolone dose should be reduced by approximately 50% when coadministered with Aprepitant to achieve exposures of methylprednisolone similar to those obtained when it is given without Aprepitant.

Output: <methylprednisolone, advise, Aprepitant>, <methylprednisolone, advise, Aprepitant>