{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Milk, milk products, and calcium-rich foods or drugs may impair the absorption of EMCYT.", "output": "<calcium, mechanism, EMCYT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone.", "output": "<allopurinol, effect, ampicillin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients.", "output": "<ampicillin, effect, allopurinol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In common with other broad-spectrum antibiotics, AUGMENTIN XR may reduce the efficacy of oral contraceptives", "output": "<broad-spectrum antibiotics, effect, contraceptives>, <AUGMENTIN XR, effect, contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Particular caution is necessary when using ROMAZICON in cases of mixed drug overdosage since the toxic effects (such as convulsions and cardiac dysrhythmias) of other drugs taken in overdose (especially cyclic antidepressants) may emerge with the reversal of the benzodiazepine effect by flumazenil.", "output": "<ROMAZICON, effect, cyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although ROMAZICON exerts a slight intrinsic anticonvulsant effect, its abrupt suppression of the protective effect of a benzodiazepine agonist can give rise to convulsions in epileptic patients.", "output": "<ROMAZICON, effect, benzodiazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ROMAZICON blocks the central effects of benzodiazepines by competitive interaction at the receptor level.", "output": "<ROMAZICON, effect, benzodiazepines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolopyridazines and others, are also blocked by ROMAZICON.", "output": "<zopiclone, effect, ROMAZICON>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution is advised when TRISENOX is coadministered with other medications that can prolong the QT interval (e.g. certain antiarrhythmics or thioridazine) or lead to electrolyte abnormalities (such as diuretics or amphotericin B).", "output": "<TRISENOX, advise, antiarrhythmics>, <TRISENOX, advise, thioridazine>, <TRISENOX, advise, diuretics>, <TRISENOX, advise, amphotericin B>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy.", "output": "<steroids, effect, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Barbiturates, phenytoin, or rifampin increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes.", "output": "<Barbiturates, mechanism, fludrocortisone acetate>, <phenytoin, mechanism, fludrocortisone acetate>, <rifampin, mechanism, fludrocortisone acetate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oxytocin or other oxytocics (concurrent use with dinoprost may result in uterine hypertonus, possibly causing uterine rupture or cervical laceration, especially in the absence of adequate cervical dilatation;", "output": "<Oxytocin, effect, dinoprost>, <oxytocics, effect, dinoprost>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetaminophen: A report of severe acetaminophen toxicity was reported in a patient receiving Isoniazid.", "output": "<acetaminophen, effect, Isoniazid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is believed that the toxicity may have resulted from a previously unrecognized interaction between isoniazid and acetaminophen and a molecular basis for this interaction has been proposed.", "output": "<isoniazid, effect, acetaminophen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furthermore it has been proposed that isoniazid resulted In induction of P-450IIE1 in the patients liver which, in turn, resulted in a greater proportion of the ingested acetaminophen being converted to the toxic metabolites.", "output": "<isoniazid, mechanism, acetaminophen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Carbamazepine: Isoniazid is known to slow the metabolism of carbamazepine and increase its serum levels Carbamazepine levels should be determined prior to concurrent administration with isoniazid, signs and symptoms of carbamazepine toxicity should be monitored closely, and appropriate dosage adjustment of the anticonvulsant should be made.", "output": "<Isoniazid, mechanism, carbamazepine>, <Carbamazepine, advise, isoniazid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: Potential interaction of Ketoconazole and Isoniazid may exist.", "output": "<Ketoconazole, int, Isoniazid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin: Isoniazid may increase serum levels of phenytoin.", "output": "<Isoniazid, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therophylline: A recent study has shown that concomitan administration of isoniazid and theophylline may cause elevated plasma levels of theophylline, and in some instances a slight decrease in the elimination of isoniazid.", "output": "<isoniazid, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Valproate: A recent case study has shown a possible increase in the plasma level of valproate when co administered with isoniazid.", "output": "<valproate, mechanism, isoniazid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Plasma valproate concentration should be monitored when isoniazid and valproate are co administered, and appropriate dosage adjustments of valproate should be made.", "output": "<isoniazid, advise, valproate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of MYOBLOC and aminoglycosides or other agents interfering with neuromuscular transmission (e.g., curare-like compounds) should only be performed with caution as the effect of the toxin may be potentiated.", "output": "<MYOBLOC, advise, aminoglycosides>, <MYOBLOC, advise, curare-like compounds>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hormonal Contraceptives, Including Oral, Injectable, Transdermal, and Implantable Contraceptives: An interaction study demonstrated that co-administration of bosentan and the oral hormonal contraceptive Ortho-Novum produced average decreases of norethindrone and ethinyl estradiol levels of 14% and 31%, respectively.", "output": "<bosentan, mechanism, Ortho-Novum>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, hormonal contraceptives, including oral, injectable, transdermal, and implantable forms, may not be reliable when TRACLEER is co-administered.", "output": "<hormonal contraceptives, effect, TRACLEER>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Steady-state bosentan plasma concentrations were 3- to 4-fold higher than in the absence of cyclosporine A.", "output": "<bosentan, mechanism, cyclosporine A>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant administration of bosentan and cyclosporine A is contraindicated.", "output": "<bosentan, advise, cyclosporine A>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of bosentan decreased the plasma concentrations of cyclosporine A (a CYP3A4 substrate) by approximately 50%.", "output": "<bosentan, mechanism, cyclosporine A>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of tacrolimus and bosentan resulted in markedly increased plasma concentrations of bosentan in animals.", "output": "<tacrolimus, mechanism, bosentan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be exercised if tacrolimus and bosentan are used together.", "output": "<tacrolimus, advise, bosentan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, the concomitant administration of TRACLEER and glyburide is contraindicated, and alternative hypoglycemic agents should be considered.", "output": "<TRACLEER, advise, glyburide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of bosentan decreased the plasma concentrations of glyburide by approximately 40%.", "output": "<bosentan, mechanism, glyburide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Bosentan is also expected to reduce plasma concentrations of other oral hypoglycemic agents that are predominantly metabolized by CYP2C9 or CYP3A4.", "output": "<Bosentan, mechanism, hypoglycemic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: Co-administration of bosentan 125 mg b.i.d. and ketoconazole, a potent CYP3A4 inhibitor, increased the plasma concentrations of bosentan by approximately 2-fold.", "output": "<bosentan, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Simvastatin and Other Statins: Co-administration of bosentan decreased the plasma concentrations of simvastatin (a CYP3A4 substrate), and its active  -hydroxy acid metabolite, by approximately 50%.", "output": "<bosentan, mechanism, simvastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Bosentan is also expected to reduce plasma concentrations of other statins that have significant metabolism by CYP3A4, such as lovastatin and atorvastatin.", "output": "<Bosentan, mechanism, statins>, <Bosentan, mechanism, lovastatin>, <Bosentan, mechanism, atorvastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients using CYP3A4 metabolized statins should have cholesterol levels monitored after TRACLEER is initiated to see whether the statin dose needs adjustment.", "output": "<statins, advise, TRACLEER>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin: Co-administration of bosentan 500 mg b.i.d. for 6 days decreased the plasma concentrations of both S-warfarin (a CYP2C9 substrate) and R-warfarin (a CYP3A4 substrate) by 29 and 38%, respectively.", "output": "<bosentan, mechanism, S-warfarin>, <bosentan, mechanism, R-warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, the potential exists for a drug interaction between WELLBUTRIN and drugs that affect the CYP2B6 isoenzyme (e.g., orphenadrine and cyclophosphamide).", "output": "<WELLBUTRIN, int, orphenadrine>, <WELLBUTRIN, int, cyclophosphamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "While not systematically studied, certain drugs may induce the metabolism of bupropion (e.g., carbamazepine, phenobarbital, phenytoin).", "output": "<bupropion, mechanism, carbamazepine>, <bupropion, mechanism, phenobarbital>, <bupropion, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a study of 15 male subjects (ages 19 to 35 years) who were extensive metabolizers of the CYP2D6 isoenzyme, daily doses of bupropion given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the Cmax, AUC, and t1/2 of desipramine by an average of approximately 2-, 5- and 2-fold, respectively.", "output": "<bupropion, mechanism, desipramine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, co-administration of bupropion with drugs that are metabolized by CYP2D6 isoenzyme including certain antidepressants (e.g., nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide), should be approached with caution and should be initiated at the lower end of the dose range of the concomitant medication.", "output": "<bupropion, advise, antidepressants>, <bupropion, advise, nortriptyline>, <bupropion, advise, imipramine>, <bupropion, advise, desipramine>, <bupropion, advise, paroxetine>, <bupropion, advise, fluoxetine>, <bupropion, advise, sertraline>, <bupropion, advise, antipsychotics>, <bupropion, advise, haloperidol>, <bupropion, advise, risperidone>, <bupropion, advise, thioridazine>, <bupropion, advise, beta-blockers>, <bupropion, advise, metoprolol>, <bupropion, advise, Type 1C antiarrhythmics>, <bupropion, advise, propafenone>, <bupropion, advise, flecainide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "MAO Inhibitors: Studies in animals demonstrate that the acute toxicity of bupropion is enhanced by the MAO inhibitor phenelzine .", "output": "<bupropion, effect, phenelzine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Levodopa and Amantadine: Limited clinical data suggest a higher incidence of adverse experiences in patients receiving bupropion concurrently with either levodopa or amantadine.", "output": "<bupropion, effect, levodopa>, <bupropion, effect, amantadine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of WELLBUTRIN Tablets to patients receiving either levodopa or amantadine concurrently should be undertaken with caution, using small initial doses and small gradual dose increases.", "output": "<WELLBUTRIN, advise, levodopa>, <WELLBUTRIN, advise, amantadine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that Lower Seizure Threshold: Concurrent administration of WELLBUTRIN and agents (e.g., antipsychotics, other antidepressants, theophylline, systemic steroids, etc.) that lower seizure threshold should be undertaken only with extreme caution.", "output": "<WELLBUTRIN, advise, antipsychotics>, <WELLBUTRIN, advise, antidepressants>, <WELLBUTRIN, advise, theophylline>, <WELLBUTRIN, advise, steroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Alcohol: In post-marketing experience, there have been rare reports of adverse neuropsychiatric events or reduced alcohol tolerance in patients who were drinking alcohol during treatment with WELLBUTRIN.", "output": "<alcohol, effect, WELLBUTRIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The consumption of alcohol during treatment with WELLBUTRIN should be minimized or avoided (also see  a href= bupropz_od.htm#CI CONTRAINDICATIONS)", "output": "<alcohol, advise, WELLBUTRIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent administration of a TNF antagonist with ORENCIA has been associated with an increased risk of serious infections and no significant additional efficacy over use of the TNF antagonists alone.", "output": "<TNF antagonist, effect, ORENCIA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent therapy with ORENCIA and TNF antagonists is not recommended.", "output": "<ORENCIA, advise, TNF antagonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There is insufficient experience to assess the safety and efficacy of ORENCIA administered concurrently with anakinra, and therefore such use is not recommended.", "output": "<ORENCIA, advise, anakinra>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cholestyramine and Charcoal Administration of cholestyramine or activated charcoal in patients (n=13) and volunteers (n=96) resulted in a rapid and significant decrease in plasma M1 (the active metabolite of leflunomide) concentration .", "output": "<cholestyramine, mechanism, leflunomide>, <activated charcoal, mechanism, leflunomide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a small (n=30) combination study of ARAVA with methotrexate, a 2- to 3-fold elevation in liver enzymes was seen in 5 of 30 patients.", "output": "<ARAVA, effect, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rifampin: Following concomitant administration of a single dose of ARAVA to subjects receiving multiple doses of rifampin, M1 peak levels were increased (~40%) over those seen when ARAVA was given alone.", "output": "<ARAVA, mechanism, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because of the potential for ARAVA levels to continue to increase with multiple dosing, caution should be used if patients are to be receiving both ARAVA and rifampin.", "output": "<ARAVA, advise, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin: Increased INR (International Normalized Ratio) when ARAVA and warfarin were co-administered has been rarely reported.", "output": "<ARAVA, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Animal studies indicate that dobutamine may be ineffective if the patient has recently received a b-blocking drug.", "output": "<dobutamine, effect, b-blocking drug>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Preliminary studies indicate that the concomitant use of dobutamine and nitroprusside results in a higher cardiac output and, usually, a lower pulmonary wedge pressure than when either drug is used alone.", "output": "<dobutamine, effect, nitroprusside>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, when heparin sodium is given with dicumarol or warfarin sodium, a period of at least 5 hours after the last intravenous dose or 24 hours after the last subcutaneous dose should elapse before blood is drawn if a valid prothrombin time is to be obtained.", "output": "<heparin sodium, advise, dicumarol>, <heparin sodium, advise, warfarin sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Platelet inhibitors: Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.", "output": "<acetylsalicylic acid, effect, heparin sodium>, <dextran, effect, heparin sodium>, <phenylbutazone, effect, heparin sodium>, <ibuprofen, effect, heparin sodium>, <indomethacin, effect, heparin sodium>, <dipyridamole, effect, heparin sodium>, <hydroxychloroquine, effect, heparin sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The anticoagulant effect of heparin is enhanced by concurrent treatment with antithrombin III (human) in patients with hereditary antithrombin III deficiency.", "output": "<heparin, effect, antithrombin III>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus in order to avoid bleeding, reduced dosage of heparin is recommended during treatment with antithrombin III (human).", "output": "<heparin, advise, antithrombin III>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs Decreasing Heparin Effect: Digitalis, tetracyclines, nicotine, or antihistamines may partially counteract the anticoagulant action of heparin sodium.", "output": "<Digitalis, effect, heparin sodium>, <tetracyclines, effect, heparin sodium>, <nicotine, effect, heparin sodium>, <antihistamines, effect, heparin sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Steady-state serum concentrations of tricyclic antidepressants are reported to fluctuate significantly when cimetidine is either added or deleted from the drug regimen.", "output": "<tricyclic antidepressants, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Serious anticholinergic symptoms (severe dry mouth, urinary retention, blurred vision) have been associated with elevations in the serum levels of tricyclic antidepressants when cimetidine is added to the drug regimen.", "output": "<tricyclic antidepressants, effect, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition, higher-than expected steady-state serum concentrations of tricyclic antidepressants have been observed when therapy is initiated in patients already taking cimetidine.", "output": "<tricyclic antidepressants, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In well-controlled patients undergoing concurrent therapy with cimetidine, a decrease in the steady-state serum concentrations of tricyclic antidepressants may occur when cime-tidine therapy is discontinued.", "output": "<cimetidine, mechanism, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The therapeutic efficacy of tricyclic antidepressants may be compromised in these patients when cimetidine is discontinued.", "output": "<tricyclic antidepressants, effect, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been greater than 2-fold increases in previously stable plasma levels of other antidepressants, including nortriptyline, when fluoxetine hydrochloride has been administered in combination with these agents.", "output": "<antidepressants, mechanism, fluoxetine hydrochloride>, <nortriptyline, mechanism, fluoxetine hydrochloride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of reserpine during therapy with a tricyclic antidepressant has been shown to produce a  stimulating  effect in some depressed patients.", "output": "<reserpine, effect, tricyclic antidepressant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Close supervision and careful adjustment of the dosage are required when nortriptyline hydrochloride is used with other anticholinergic drugs or sympathomimetic drugs.", "output": "<nortriptyline hydrochloride, advise, anticholinergic drugs>, <nortriptyline hydrochloride, advise, sympathomimetic drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, co-administration of tricyclic antidepressants with other drugs that are metabolized by this isoenzyme, including other antidepressants, phenothiazines, carbamazepine, and Type 1C antiarrhythmics (eg, propafenone, flecainide, and encainide), or that inhibit this enzyme (eg, quinidine), should be approached with caution.", "output": "<tricyclic antidepressants, advise, antidepressants>, <tricyclic antidepressants, advise, phenothiazines>, <tricyclic antidepressants, advise, carbamazepine>, <tricyclic antidepressants, advise, Type 1C antiarrhythmics>, <tricyclic antidepressants, advise, propafenone>, <tricyclic antidepressants, advise, flecainide>, <tricyclic antidepressants, advise, encainide>, <tricyclic antidepressants, advise, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although specific drug interaction studies have not been conducted with ALPHAGAN P, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered.", "output": "<ALPHAGAN P, advise, CNS depressants>, <ALPHAGAN P, advise, alcohol>, <ALPHAGAN P, advise, barbiturates>, <ALPHAGAN P, advise, opiates>, <ALPHAGAN P, advise, sedatives>, <ALPHAGAN P, advise, anesthetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.It is not known whether the concurrent use of these agents with ALPHAGAN P in humans can lead to resulting interference with the IOP lowering effect.", "output": "<Tricyclic antidepressants, effect, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oral Anticoagulants CAUTION SHOULD BE EXERCISED WHEN COUMARIN ANTICOAGULANTS ARE GIVEN IN CONJUNCTION WITH TRICOR.", "output": "<COUMARIN ANTICOAGULANTS, advise, TRICOR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "HMG-CoA reductase inhibitors: The combined use of TRICOR and HMG-CoA reductase inhibitors should be avoided unless the benefit of further alterations in lipid levels is likely to outweigh the increased risk of this drug combination.", "output": "<TRICOR, advise, HMG-CoA reductase inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Resins: Since bile acid sequestrants may bind other drugs given concurrently, patients should take TRICOR at least 1 hour before or 4-6 hours after a bile acid binding resin to avoid impeding its absorption.", "output": "<TRICOR, mechanism, bile acid binding resin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporine: Because cyclosporine can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including TRICOR, there is a risk that an interaction will lead to deterioration.", "output": "<cyclosporine, effect, fibrate drugs>, <cyclosporine, effect, TRICOR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The benefits and risks of using TRICOR with immunosuppressants and other potentially nephrotoxic agents should be carefully considered, and the lowest effective dose employed", "output": "<TRICOR, advise, immunosuppressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, fenofibrate should be taken at least 1 hour before or 4-6 hours after a bile acid binding resin to avoid impeding its absorption .", "output": "<fenofibrate, advise, bile acid binding resin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of fenofibrate (equivalent to 145mg TRICOR) with pravastatin (40 mg) once daily for 10 days has been shown to increase the mean Cmax and AUC values for pravastatin by 36% (range from 69% decrease to 321% increase) and 28% (range from 54% decrease to 128% increase), respectively, and for 3 -hydroxy-iso-pravastatin by 55% (range from 32% decrease to 314% increase) and 39% (range from 24% decrease to 261% increase), respectively in 23 healthy adults.", "output": "<fenofibrate, mechanism, pravastatin>, <TRICOR, mechanism, pravastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of fenofibrate (equivalent to 145 mg TRICOR) with atorvastatin (20 mg) once daily for 10 days resulted in approximately 17% decrease (range from 67% decrease to 44% increase) in atorvastatin AUC values in 22 healthy males.", "output": "<fenofibrate, mechanism, atorvastatin>, <TRICOR, mechanism, atorvastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The daily dose of ENABLEX should not exceed 7.5 mg when coadministered with potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, nelfinavir, clarithromycin and nefazadone) .", "output": "<ENABLEX, advise, ketoconazole>, <ENABLEX, advise, itraconazole>, <ENABLEX, advise, ritonavir>, <ENABLEX, advise, nelfinavir>, <ENABLEX, advise, clarithromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be taken when ENABLEX is used concomitantly with medications that are predominantly metabolized by CYP2D6 and which have a narrow therapeutic window, such as flecainide, thioridazine and tricyclic antidepressants (see CLINICAL PHARMACOLOGY).", "output": "<ENABLEX, advise, flecainide>, <ENABLEX, advise, thioridazine>, <ENABLEX, advise, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant use of ENABLEX with other anticholinergic agents may increase the frequency and/or severity of dry mouth, constipation, blurred vision and other anticholinergic pharmacological effects.", "output": "<ENABLEX, effect, anticholinergic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent administration of HEXALEN and antidepressants of the MAO inhibitor class may cause severe orthostatic hypotension.Cimetidine, an inhibitor of microsomal drug metabolism, increased altretamines half-life and toxicity in a rat model.", "output": "<HEXALEN, effect, antidepressants of the MAO inhibitor class>, <Cimetidine, mechanism, altretamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Data from a randomized trial of HEXALEN and cisplatin plus or minus pyridoxine in ovarian cancer indicated that pyridoxine significantly reduced neurotoxicity;", "output": "<HEXALEN, effect, cisplatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "however, it adversely affected response duration suggesting that pyridoxine should not be administered with HEXALEN and/or cisplatin.1", "output": "<pyridoxine, advise, HEXALEN>, <pyridoxine, advise, cisplatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Special consideration should be given to the administration of ETHYOL in patients receiving antihypertensive medications or other drugs that could cause or potentiate hypotension.", "output": "<ETHYOL, advise, antihypertensive medications>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Valproate: Tiagabine causes a slight decrease (about 10%) in steady-state valproate concentrations.", "output": "<Tiagabine, mechanism, valproate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Effects of other Antiepilepsy Drugs (AEDs) on GABITRIL : Carbamazepine: Population pharmacokinetic analyses indicate that tiagabine clearance is 60% greater in patients taking carbamazepine with or without other enzyme- inducing AEDs.", "output": "<tiagabine, mechanism, carbamazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin: Population pharmacokinetic analyses indicate that tiagabine clearance is 60% greater in patients taking phenytoin with or without other enzyme- inducing AEDs.", "output": "<tiagabine, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenobarbital (Primidone): Population pharmacokinetic analyses indicate that tiagabine clearance is 60% greater in patients taking phenobarbital (primidone) with or without other enzyme-inducing AEDs.", "output": "<tiagabine, mechanism, phenobarbital>, <tiagabine, mechanism, primidone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Valproate: The addition of tiagabine to patients taking valproate chronically had no effect on tiagabine pharmacokinetics, but valproate significantly decreased tiagabine binding in vitro from 96.3 to 94.8%, which resulted in an increase of approximately 40% in the free tiagabine concentration.", "output": "<valproate, mechanism, tiagabine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because of the possible additive effects of drugs that may depress the nervous system, ethanol or triazolam should be used cautiously in combination with tiagabine.", "output": "<ethanol, advise, tiagabine>, <triazolam, advise, tiagabine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sulfapyridine may interact with any of the following: - Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or", "output": "<Sulfapyridine, int, Acetaminophen>, <Sulfapyridine, int, Tylenol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Antidiabetics, oral (diabetes medicine you take by mouth) Use of oral antidiabetics with sulfapyridine may increase the chance of side effects affecting the blood and/or the side effects or oral antidiabetics", "output": "<antidiabetics, effect, sulfapyridine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Methotrexate (e.g., Mexate) Use of methotrexate with sulfapyridine may increase the chance of side effects affecting the liver and/or the side effects of methotrexate", "output": "<methotrexate, effect, sulfapyridine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Methyldopa (e.g., Aldomet) Use of methyldopa with sulfapyridine may increase the chance of side effects affecting the liver and/or the blood", "output": "<methyldopa, effect, sulfapyridine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Phenytoin (e.g., Dilantin) Use of phenytoin with sulfapyridine may increase the chance of side effects affecting the liver and/or the side effects of phenytoin", "output": "<phenytoin, effect, sulfapyridine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Elevated plasma levels of theophylline have been reported with concomitant use of some quinolones.", "output": "<theophylline, mechanism, quinolones>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been reports of theophylline-related side-effects in patients on concomitant theophylline-quinolone therapy.", "output": "<theophylline, effect, quinolone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Quinolones have also been shown to interfere with the metabolism of caffeine.", "output": "<Quinolones, mechanism, caffeine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although this interaction has not been reported with cinoxacin, caution should be exercised when cinoxacin is given concomitantly with caffeine-containing products.", "output": "<cinoxacin, advise, caffeine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids or sucralfate substantially interfere with the absorption of some quinolones, resulting in low urine levels.", "output": "<Antacids, mechanism, quinolones>, <sucralfate, mechanism, quinolones>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Also, concomitant administration of quinolones with products containing iron, multivitamins containing zinc, or Videx (didanosine) chewable/buffered tablets or the pediatric powder for oral solution may result in low urine levels.", "output": "<quinolones, mechanism, iron>, <quinolones, mechanism, zinc>, <quinolones, mechanism, Videx>, <quinolones, mechanism, didanosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Quinolones, including cinoxacin, may enhance the effects of oral anticoagulants, such as warfarin or its derivatives.", "output": "<Quinolones, effect, anticoagulants>, <Quinolones, effect, warfarin>, <cinoxacin, effect, anticoagulants>, <cinoxacin, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Seizures have been reported in patients taking another quinolone class antimicrobial and the nonsteroidal anti-inflammatory drug fenbufen concurrently.", "output": "<quinolone class antimicrobial, effect, nonsteroidal anti-inflammatory drug>, <quinolone class antimicrobial, effect, fenbufen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Physicians are provided this information to increase awareness of the potential for serious interactions when cinoxacin and certain nonsteroidal anti-inflammatory agents are administered concomitantly.", "output": "<cinoxacin, advise, nonsteroidal anti-inflammatory agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Elevated cyclosporine serum levels have been reported with the concomitant use of quinolones and cyclosporine.", "output": "<quinolones, mechanism, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of quinolones with antacids containing aluminum, magnesium, or calcium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron or zinc, or with formulations containing divalent and trivalent cations such as VIDEX (didanosine) chewable/buffered tablets or the pediatric powder for oral solution, may substantially interfere with the absorption of quinolones, resulting in systemic concentrations considerably lower than desired.", "output": "<quinolones, mechanism, aluminum>, <quinolones, mechanism, magnesium>, <quinolones, mechanism, calcium>, <quinolones, mechanism, sucralfate>, <quinolones, mechanism, iron>, <quinolones, mechanism, multivitamins>, <quinolones, mechanism, iron>, <quinolones, mechanism, zinc>, <quinolones, mechanism, VIDEX>, <quinolones, mechanism, didanosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caffeine Theobromine Grepafloxacin, like other quinolones, may inhibit the metabolism of caffeine and theobromine.", "output": "<Grepafloxacin, mechanism, caffeine>, <Grepafloxacin, mechanism, theobromine>, <quinolones, mechanism, caffeine>, <quinolones, mechanism, theobromine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Theophylline: Grepafloxacin is a competitive inhibitor of the metabolism of theophylline.", "output": "<Grepafloxacin, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Serum theophylline concentrations increase when grepafloxacin is initiated in a patient maintained on theophylline.", "output": "<grepafloxacin, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When initiating a multi-day course of grepafloxacin in a patient maintained on theophylline, the theophylline maintenance dose should be halved for the period of concurrent use of grepafloxacin and monitoring of serum theophylline concentrations should be initiated as a guide to further dosage adjustments.", "output": "<theophylline, advise, grepafloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, because some quinolones have been reported to enhance the effects of warfarin or its derivatives, prothrombin time or other suitable anticoagulation test should be monitored closely if a quinolone antimicrobial is administered with warfarin or its derivatives.", "output": "<quinolones, effect, warfarin>, <quinolone antimicrobial, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs Metabolized by Cytochrome P450 Enzymes The drug interaction study evaluating the effect of grepafloxacin on theophylline indicates that grepafloxacin inhibits theophylline metabolism, which is mediated by CYP1A2.", "output": "<grepafloxacin, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition, other quinolones have been reported to decrease the CYP3A4-mediated metabolism of cyclosporine.", "output": "<quinolones, mechanism, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nonsteroidal Anti-inflammatory Drugs (NSAIDs): The concomitant administration of a nonsteroidal anti inflammatory drug with a quinolone may increase the risks of CNS stimulation and convulsions.", "output": "<nonsteroidal anti inflammatory drug, effect, quinolone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antidiabetic Agents: Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent.", "output": "<quinolones, effect, antidiabetic agent>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concurrent use of Robinul Injection with other anticholinergics or medications with anticholinergic activity, such as phenothiazines, antiparkinson drugs, or tricyclic antidepressants, may intensify the antimuscarinic effects and may result in an increase in anticholinergic side effects.", "output": "<Robinul, effect, anticholinergics>, <Robinul, effect, phenothiazines>, <Robinul, effect, antiparkinson drugs>, <Robinul, effect, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of Robinul Injection and potassium chloride in a wax matrix may increase the severity of potassium chloride-induced gastrointestinal lesions as a result of a slower gastrointestinal transit time.", "output": "<Robinul, mechanism, potassium chloride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oral doses of Antizol (10-20 mg/kg), via alcohol dehydrogenase inhibition, significantly reduced the rate of elimination of ethanol (by approximately 40%) given to healthy volunteers in moderate doses.", "output": "<Antizol, mechanism, ethanol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Similarly, ethanol decreased the rate of elimination of Antizol (by approximately 50%) by the same mechanism.", "output": "<ethanol, mechanism, Antizol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Reciprocal interactions may occur with concomitant use of Antizol and drugs that increase or inhibit the cytochrome P450 system (e.g., phenytoin, carbamazepine, cimetidine, ketoconazole), though this has not been studied", "output": "<Antizol, mechanism, phenytoin>, <Antizol, mechanism, carbamazepine>, <Antizol, mechanism, cimetidine>, <Antizol, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When administered concurrently, the following drugs may interact with beta-adrenergic receptor blocking agents: Anesthetics, general: exaggeration of the hypotension induced by general anesthetics.", "output": "<beta-adrenergic receptor blocking agents, int, Anesthetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Elevated plasma levels of theophylline have been reported with concomitant quinolone use.", "output": "<theophylline, mechanism, quinolone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been reports of theophylline-related side effects in patients on concomitant therapy with quinolones and theophylline.", "output": "<quinolones, effect, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Quinolones have been shown to interfere with the metabolism of caffeine.", "output": "<Quinolones, mechanism, caffeine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Quinolones, including nalidixic acid, may enhance the effects of the oral anticoagulant warfarin or its derivatives.", "output": "<Quinolones, effect, warfarin>, <nalidixic acid, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nitrofurantoin interferes with the therapeutic action of nalidixic acid.", "output": "<Nitrofurantoin, effect, nalidixic acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "and Videx , (Didanosine), chewable/buffered tablets or the pediatric powder for oral solution may substantially interfere with the absorption of quinolones, resulting in systemic levels considerably lower than desired.", "output": "<Videx, mechanism, quinolones>, <Didanosine, mechanism, quinolones>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Elevated serum levels of cyclosporine have been reported with the concomitant use of some quinolones and cyclosporine.", "output": "<quinolones, mechanism, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Metformin: In healthy subjects given single 500 mg doses of cephalexin and metformin, plasma metformin mean cmax and AUC increased by an average of 34% and 24%, respectively, and metformin mean renal clearance decreased by 14%.", "output": "<cephalexin, mechanism, metformin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although not observed in this study, adverse effects could potentially arise from co-administration of cephalexin and metformin by inhibition of tubular secretion via organic cationic transporter systems.", "output": "<cephalexin, mechanism, metformin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Accordingly, careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking cephalexin and metformin.", "output": "<cephalexin, advise, metformin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid: As with other b-lactams, the renal excretion of cephalexin is inhibited by probenecid.", "output": "<cephalexin, mechanism, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be exercised when administering ETOPOPHOS with drugs that are known to inhibit phosphatase activities (e.g., levamisole hydrochloride).", "output": "<ETOPOPHOS, advise, levamisole hydrochloride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "High-dose cyclosporin A resulting in concentrations above 2000 ng/mL administered with oral etoposide has led to an 80% increase in etoposide exposure with a 38% decrease in total body clearance of etoposide compared to etoposide alone.", "output": "<cyclosporin A, mechanism, etoposide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diuretics: Patients on diuretics, especially those with intravascular volume depletion, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with fosinopril sodium.", "output": "<diuretics, effect, fosinopril sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The possibility of hypotensive effects can be minimized by either discontinuing the diuretic or increasing salt intake prior to initiation of treatment with fosinopril sodium.", "output": "<diuretic, effect, fosinopril sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Potassium Supplements and Potassium-Sparing Diuretics: Fosinopril sodium can attenuate potassium loss caused by thiazide diuretics.", "output": "<Fosinopril sodium, effect, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium.", "output": "<ACE inhibitors, effect, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids: In a clinical pharmacology study, coadministration of an antacid (aluminum hydroxide, magnesium hydroxide, and simethicone) with fosinopril reduced serum levels and urinary excretion of fosinoprilat as compared with fosinopril administered alone, suggesting that antacids may impair absorption of fosinopril.", "output": "<antacid, mechanism, fosinopril>, <aluminum hydroxide, mechanism, fosinopril>, <magnesium hydroxide, mechanism, fosinopril>, <simethicone, mechanism, fosinopril>, <antacids, mechanism, fosinopril>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drug Interactions: Flupenthixol may interact with some drugs, like Monoamine oxidase inhibitors (MAOI): MAOI could theoretically affect flupenthixol pharmacodynamics - Arecoline - Eproxindine - Ethanol: Flupenthixol and Ethanol cause additive CNS depression - Tricyclic antidepressants: Flupenthixol increases the effect of Tricyclic antidepressants", "output": "<Flupenthixol, int, Monoamine oxidase inhibitors>, <Flupenthixol, int, MAOI>, <MAOI, effect, flupenthixol>, <Flupenthixol, effect, Ethanol>, <Flupenthixol, effect, Tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Curariform muscle relaxants (eg, tubocurarine) and other drugs, including ether, succinylcholine, gallamine, decamethonium and sodium citrate, potentiate the neuromuscular blocking effect and should be used with extreme caution in patients being treated with Coly-Mycin M Parenteral.", "output": "<Curariform muscle relaxants, effect, Coly-Mycin M>, <tubocurarine, effect, Coly-Mycin M>, <succinylcholine, effect, Coly-Mycin M>, <gallamine, effect, Coly-Mycin M>, <decamethonium, effect, Coly-Mycin M>, <sodium citrate, effect, Coly-Mycin M>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sodium cephalothin may enhance the nephrotoxicity of Coly-Mycin M Parenteral.", "output": "<Sodium cephalothin, effect, Coly-Mycin M>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant use of sodium cephalothin and Coly-Mycin M Parenteral should be avoided.", "output": "<sodium cephalothin, advise, Coly-Mycin M>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hypotension - Patients on Diuretic Therapy: Patients on diuretics, and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with PRINIVIL.", "output": "<diuretics, effect, PRINIVIL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The possibility of hypotensive effects with PRINIVIL can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with PRINIVIL.", "output": "<diuretic, effect, PRINIVIL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If it is necessary to continue the diuretic, initiate therapy with PRINIVIL at a dose of 5 mg daily, and provide close medical supervision after the initial dose until blood pressure has stabilized.", "output": "<diuretic, advise, PRINIVIL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When a diuretic is added to the therapy of a patient receiving PRINIVIL, an additional antihypertensive effect is usually observed.", "output": "<diuretic, effect, PRINIVIL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Studies with ACE inhibitors in combination with diuretics indicate that the dose of the ACE inhibitor can be reduced when it is given with a diuretic.", "output": "<ACE inhibitor, advise, diuretic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Non-steroidal Anti-inflammatory Agents: In some patients with compromised renal function who are being treated with non-steroidal anti-inflammatory drugs, the co-administration of lisinopril may result in a further deterioration of renal function.", "output": "<non-steroidal anti-inflammatory drugs, effect, lisinopril>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors, including lisinopril.", "output": "<NSAIDs, effect, ACE inhibitors>, <NSAIDs, effect, lisinopril>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE inhibitors.", "output": "<NSAIDs, advise, ACE inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Agents Increasing Serum Potassium: PRINIVIL attenuates potassium loss caused by thiazide-type diuretics.", "output": "<PRINIVIL, effect, thiazide-type diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Use of PRINIVIL with potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.", "output": "<PRINIVIL, effect, potassium-sparing diuretics>, <PRINIVIL, effect, spironolactone>, <PRINIVIL, effect, triamterene>, <PRINIVIL, effect, amiloride>, <PRINIVIL, effect, potassium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors.", "output": "<lithium, effect, ACE inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium toxicity was usually reversible upon discontinuation of lithium and the ACE inhibitor.", "output": "<lithium, effect, ACE inhibitor>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended that serum lithium levels be monitored frequently if PRINIVIL is administered concomitantly with lithium.", "output": "<PRINIVIL, advise, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The CNS effects of butalbital may be enhanced by monoamine oxidase (MAO) inhibitors.", "output": "<butalbital, effect, monoamine oxidase (MAO) inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Butalbital, acetaminophen and caffeine may enhance the effects of: other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression.", "output": "<Butalbital, effect, narcotic analgesic>, <Butalbital, effect, alcohol>, <Butalbital, effect, anesthetics>, <Butalbital, effect, tranquilizers>, <Butalbital, effect, chlordiazepoxide>, <Butalbital, effect, sedative-hypnotics>, <Butalbital, effect, CNS depressants>, <acetaminophen, effect, narcotic analgesic>, <acetaminophen, effect, alcohol>, <acetaminophen, effect, anesthetics>, <acetaminophen, effect, tranquilizers>, <acetaminophen, effect, chlordiazepoxide>, <acetaminophen, effect, sedative-hypnotics>, <acetaminophen, effect, CNS depressants>, <caffeine, effect, narcotic analgesic>, <caffeine, effect, alcohol>, <caffeine, effect, anesthetics>, <caffeine, effect, tranquilizers>, <caffeine, effect, chlordiazepoxide>, <caffeine, effect, sedative-hypnotics>, <caffeine, effect, CNS depressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "CNS-Active Drugs Ethanol: Sonata 10 mg potentiated the CNS-impairing effects of ethanol 0.75 g/kg on balance testing and reaction time for 1 hour after ethanol administration and on the digit symbol substitution test (DSST), symbol copying test, and the variability component of the divided attention test for 2.5 hours after ethanol administration.", "output": "<Sonata, effect, ethanol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Imipramine: Coadministration of single doses of Sonata 20 mg and imipramine 75 mg produced additive effects on decreased alertness and impaired psychomotor performance for 2 to 4 hours after administration.", "output": "<Sonata, effect, imipramine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thioridazine: Coadministration of single doses of Sonata 20 mg and thioridazine 50 mg produced additive effects on decreased alertness and impaired psychomotor performance for 2 to 4 hours after administration.", "output": "<Sonata, effect, thioridazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Promethazine: Coadministration of a single dose of zaleplon and promethazine (10 and 25 mg, respectively) resulted in a 15% decrease in maximal plasma concentrations of zaleplon, but no change in the area under the plasma concentration-time curve.", "output": "<zaleplon, mechanism, promethazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Multiple-dose administration of the potent CYP3A4 inducer rifampin (600 mg every 24 hours, q24h, for 14 days), however, reduced zaleplon Cmax and AUC by approximately 80%.", "output": "<rifampin, mechanism, zaleplon>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of single, oral doses of zaleplon with erythromycin (10 mg and 800 mg, respectively), a strong, selective CYP3A4 inhibitor produced a 34% increase in zaleplons maximal plasma concentrations and a 20% increase in the area under the plasma concentration-time curve.", "output": "<zaleplon, mechanism, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other strong selective CYP3A4 inhibitors such as ketoconazole can also be expected to increase the exposure of zaleplon.", "output": "<ketoconazole, mechanism, zaleplon>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs That Inhibit Both Aldehyde Oxidase and CYP3A4 Cimetidine: Cimetidine inhibits both aldehyde oxidase (in vitro) and CYP3A4 (in vitro and in vivo), the primary and secondary enzymes, respectively, responsible for zaleplon metabolism.", "output": "<Cimetidine, mechanism, zaleplon>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of Sonata (10 mg) and cimetidine (800 mg) produced an 85% increase in the mean Cmax and AUC of zaleplon.", "output": "<Sonata, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A pharmacokinetic study evaluating the administration of a single dose of INSPRA 100 mg with ketoconazole 200 mg BID, a potent inhibitor of the CYP3A4 pathway, showed a 1.7-fold increase in Cmax of eplerenone and a 5.4-fold increase in AUC of eplerenone.", "output": "<INSPRA, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of eplerenone with other CYP3A4 inhibitors (e.g., erythromycin 500 mg BID, verapamil 240 mg QD, saquinavir 1200 mg TID, fluconazole 200 mg QD) resulted in increases in Cmax of eplerenone ranging from 1.4- to 1.6- fold and AUC from 2.0- to 2.9- fold.", "output": "<eplerenone, mechanism, erythromycin>, <eplerenone, mechanism, verapamil>, <eplerenone, mechanism, saquinavir>, <eplerenone, mechanism, fluconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ACE Inhibitors and Angiotensin II Receptor Antagonists (Hypertension)- In clinical studies of patients with hypertension, the addition of INSPRA 50 to 100 mg to ACE inhibitors and angiotensin II receptor antagonists increased mean serum potassium slightly (about 0.09-0.13 mEq/L).", "output": "<INSPRA, effect, ACE inhibitors>, <INSPRA, effect, angiotensin II receptor antagonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a study in diabetics with microalbuminuria INSPRA 200 mg combined with the ACE inhibitor enalapril 10 mg increased the frequency of hyperkalemia (serum potassium  5.5 mEq/L) from 17% on enalapril alone to 38%.", "output": "<INSPRA, effect, enalapril>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Serum lithium levels should be monitored frequently if INSPRA is administered concomitantly with lithium.", "output": "<INSPRA, advise, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The administration of other potassium-sparing antihypertensives with NSAIDs has been shown to reduce the antihypertensive effect in some patients and result in severe hyperkalemia in patients with impaired renal function.", "output": "<potassium-sparing antihypertensives, effect, NSAIDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, when INSPRA and NSAIDs are used concomitantly, patients should be observed to determine whether the desired effect on blood pressure is obtained.", "output": "<INSPRA, advise, NSAIDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aminoglutethimide: Aminoglutethimide may diminish adrenal suppression by corticosteroids.", "output": "<Aminoglutethimide, effect, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Amphotericin B injection and potassium-depleting agents: When corticosteroids are administered concomitantly with potassium-depleting agents (e.g., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia.", "output": "<corticosteroids, advise, amphotericin B>, <corticosteroids, advise, diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition, there have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure.", "output": "<amphotericin B, effect, hydrocortisone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antibiotics: Macrolide antibiotics have been reported to cause a significant decrease in corticosteroid clearance.", "output": "<Macrolide antibiotics, mechanism, corticosteroid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticholinesterases: Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis.", "output": "<anticholinesterase agents, effect, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If possible, anticholinesterase agents should be withdrawn at least 24 hours before initiating corticosteroid therapy.", "output": "<anticholinesterase agents, advise, corticosteroid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticoagulants, oral: Co-administration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports.", "output": "<corticosteroids, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antidiabetics: Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required.", "output": "<corticosteroids, effect, antidiabetic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cholestyramine: Cholestyramine may increase the clearance of corticosteroids.", "output": "<Cholestyramine, mechanism, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently.", "output": "<cyclosporine, effect, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ephedrine: Ephedrine may enhance the metabolic clearance of corticosteroids, resulting in decreased blood levels and lessened physiologic activity, thus requiring an increase in corticosteroid dosage.", "output": "<Ephedrine, mechanism, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Estrogens, including oral contraceptives: Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect.", "output": "<Estrogens, mechanism, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hepatic Enzyme Inducers, Inhibitors and Substrates: Drugs which induce cytochrome P450 3A4 (CYP 3A4) enzyme activity (e.g., barbiturates, phenytoin, carbamazepine, rifampin) may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased.", "output": "<barbiturates, mechanism, corticosteroids>, <phenytoin, mechanism, corticosteroids>, <carbamazepine, mechanism, corticosteroids>, <rifampin, mechanism, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs which inhibit CYP 3A4 (e.g., ketoconazole, macrolide antibiotics such as erythromycin) have the potential to result in increased plasma concentrations of corticosteroids.", "output": "<ketoconazole, mechanism, corticosteroids>, <macrolide antibiotics, mechanism, corticosteroids>, <erythromycin, mechanism, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: Ketoconazole has been reported to decrease the metabolism of certain corticosteroids by up to 60%, leading to increased risk of corticosteroid side effects.", "output": "<Ketoconazole, mechanism, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition, ketoconazole alone can inhibit adrenal corticosteroid synthesis and may cause adrenal insufficiency during corticosteroid withdrawal.", "output": "<ketoconazole, effect, corticosteroid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nonsteroidal anti-inflammatory agents (NSAIDS): Concomitant use of aspirin (or other nonsteroidal antiinflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects.", "output": "<aspirin, effect, corticosteroids>, <nonsteroidal antiinflammatory agents, effect, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.", "output": "<Aspirin, advise, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The clearance of salicylates may be increased with concurrent use of corticosteroids.", "output": "<salicylates, mechanism, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin: In post-marketing experience, there have been reports of both increases and decreases in phenytoin levels with dexamethasone co-administration, leading to alterations in seizure control.", "output": "<phenytoin, mechanism, dexamethasone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Vaccines: Patients on corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody response.", "output": "<corticosteroid, effect, live vaccines>, <corticosteroid, effect, inactivated vaccines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines.", "output": "<Corticosteroids, effect, live attenuated vaccines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Routine administration of vaccines or toxoids should be deferred until corticosteroid therapy is discontinued if possible.", "output": "<vaccines, advise, corticosteroid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cytosine arabinoside, a cytostatic agent, has been reported to inactivate the antifungal activity of flucytosine by competitive inhibition.", "output": "<Cytosine arabinoside, effect, flucytosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "THE POTENTIATING ACTION OF HYDROXYZINE MUST BE CONSIDERED WHEN THE DRUG IS USED IN CONJUNCTION WITH CENTRAL NERVOUS SYSTEM DEPRESSANTS SUCH AS NARCOTICS, NON-NARCOTIC ANALGESICS AND BARBITURATES.", "output": "<HYDROXYZINE, effect, CENTRAL NERVOUS SYSTEM DEPRESSANTS>, <HYDROXYZINE, effect, NARCOTICS>, <HYDROXYZINE, effect, NON-NARCOTIC ANALGESICS>, <HYDROXYZINE, effect, BARBITURATES>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore when central nervous system depressants are administered concomitantly with hydroxyzine their dosage should be reduced.", "output": "<central nervous system depressants, advise, hydroxyzine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Amantadine, tricyclic antidepressants, and MAOIs may increase anticholinergic effect of clidinium.", "output": "<Amantadine, effect, clidinium>, <tricyclic antidepressants, effect, clidinium>, <MAOIs, effect, clidinium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Clidinium may decrease the effect of phenothiazines, levodopa, and ketoconazole.", "output": "<Clidinium, effect, phenothiazines>, <Clidinium, effect, levodopa>, <Clidinium, effect, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.", "output": "<oxyphenbutazone, mechanism, androgens>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements.", "output": "<androgens, effect, insulin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticonvulsants: In a pharmacokinetic study, maximum plasma concentrations of felodipine were considerably lower in epileptic patients on long-term anticonvulsant therapy (eg, phenytoin, carbamazepine, or phenobarbital) than in healthy volunteers.", "output": "<felodipine, mechanism, anticonvulsant>, <felodipine, mechanism, phenytoin>, <felodipine, mechanism, carbamazepine>, <felodipine, mechanism, phenobarbital>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: As with other NSAIDs, concomitant administration of Ponstel and aspirin is not generally recommended because of the potential of increased adverse effects.", "output": "<NSAIDs, advise, aspirin>, <Ponstel, advise, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methotrexate: NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices.", "output": "<NSAIDs, mechanism, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be used when NSAIDs are administered concomitantly with methotrexate.", "output": "<NSAIDs, advise, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors.", "output": "<NSAIDs, effect, ACE inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE inhibitors.", "output": "<NSAIDs, advise, ACE inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide: Clinical studies, as well as post-marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.", "output": "<NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "During concomitant therapy of Ponstel with furosemide, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.", "output": "<Ponstel, advise, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.", "output": "<NSAIDs, mechanism, lithium>, <NSAIDs, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.", "output": "<NSAIDs, advise, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.", "output": "<warfarin, effect, NSAIDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids: In a single dose study (n=6), ingestion of an antacid containing 1.7-gram of magnesium hydroxide with 500-mg of mefenamic acid increased the Cmax and AUC of mefenamic acid by 125% and 36%, respectively.  A number of compounds are inhibitors of CYP2C9 including fluconazole, lovastatin and trimethoprim.", "output": "<magnesium hydroxide, mechanism, mefenamic acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oral Anticoagulants: In some normal volunteers, the concomitant administration of diflunisal and warfarin, acenocoumarol, or phenprocoumon resulted in prolongation of prothrombin time.", "output": "<diflunisal, effect, warfarin>, <diflunisal, effect, acenocoumarol>, <diflunisal, effect, phenprocoumon>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This may occur because diflunisal competitively displaces coumarins from protein binding sites.", "output": "<diflunisal, mechanism, coumarins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Accordingly, when diflunisal is administered with oral anticoagulants, the prothrombin time should be closely monitored during and for several days after concomitant drug administration.", "output": "<diflunisal, advise, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hydrochlorothiazide: In normal volunteers, concomitant administration of diflunisal and hydrochlorothiazide resulted in significantly increased plasma levels of hydrochlorothiazide.", "output": "<diflunisal, mechanism, hydrochlorothiazide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diflunisal decreased the hyperuricemic effect of hydrochlorothiazide.", "output": "<Diflunisal, effect, hydrochlorothiazide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diflunisal decreased the hyperuricemic effect of furosemide.", "output": "<Diflunisal, effect, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids: Concomitant administration of antacids may reduce plasma levels of diflunisal.", "output": "<antacids, mechanism, diflunisal>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetaminophen: In normal volunteers, concomitant administration of diflunisal and acetaminophen resulted in an approximate 50% increase in plasma levels of acetaminophen.", "output": "<diflunisal, mechanism, acetaminophen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since acetaminophen in high doses has been associated with hepatotoxicity, concomitant administration of diflunisal and acetaminophen should be used cautiously, with careful monitoring of patients.", "output": "<diflunisal, advise, acetaminophen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of diflunisal and acetaminophen in dogs, but not in rats, at approximately 2 times the recommended maximum human therapeutic dose of each (40 to 52 mg/kg/day of diflunisal/acetaminophen) resulted in greater gastrointestinal toxicity than when either drug was administered alone.", "output": "<diflunisal, effect, acetaminophen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methotrexate: Caution should be used if diflunisal is administered concomitantly with methotrexate.", "output": "<diflunisal, advise, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nonsteroidal anti-inflammatory drugs have been reported to decrease the tubular secretion of methotrexate and to potentiate its toxicity.", "output": "<Nonsteroidal anti-inflammatory drugs, mechanism, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporine: Administration of nonsteroial anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin.", "output": "<nonsteroial anti-inflammatory drugs, mechanism, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored.", "output": "<NSAIDs, advise, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nonsteroidal Anti-Inflammatory Drugs: The administration of diflunisal to normal volunteers receiving indomethacin decreased the renal clearance and significantly increased the plasma levels of indomethacin.", "output": "<diflunisal, mechanism, indomethacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In some patients the combined use of indomethacin and diflunisal has been associated with fatal gastrointestinal hemorrhage.", "output": "<indomethacin, effect, diflunisal>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, indomethacin and diflunisal should not be used concomitantly.", "output": "<indomethacin, advise, diflunisal>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant use of diflunisal tablets and other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy.", "output": "<diflunisal, effect, NSAIDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: In normal volunteers, a small decrease in diflunisal levels was observed when multiple doses of diflunisal and aspirin were administered concomitantly.", "output": "<diflunisal, mechanism, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sulindac: The concomitant administration of diflunisal and sulindac in normal volunteers resulted in lowering of the plasma levels of the active sulindac sulfide metabolite by approximately one-third.", "output": "<diflunisal, mechanism, sulindac>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Naproxen: The concomitant administration of diflunisal and naproxen in normal volunteers had no effect on the plasma levels of naproxen, but significantly decreased the urinary excretion of naproxen and its glucuronide metabolite.", "output": "<diflunisal, mechanism, naproxen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lincomycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents.", "output": "<Lincomycin, effect, neuromuscular blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antagonism between lincomycin and erythromycin in vitro has been demonstrated.", "output": "<lincomycin, effect, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Careful observation is required when amantadine is administered concurrently with central nervous system stimulants.", "output": "<amantadine, advise, central nervous system stimulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since Zarontin (ethosuximide) may interact with concurrently administered antiepileptic drugs, periodic serum level determinations of these drugs may be necessary (eg, ethosuximide may elevate phenytoin serum levels and valproic acid has been reported to both increase and decrease ethosuximide levels).", "output": "<Zarontin, int, antiepileptic drugs>, <ethosuximide, int, antiepileptic drugs>, <ethosuximide, mechanism, phenytoin>, <valproic acid, mechanism, ethosuximide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of 0.1-mg/kg (2 x ED95) NIMBEX at 10% or 95% recovery following an intubating dose of succinylcholine (1 mg/kg) produced  95% neuromuscular block.", "output": "<NIMBEX, effect, succinylcholine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The time to onset of maximum block following NIMBEX is approximately 2 minutes faster with prior administration of succinylcholine.", "output": "<NIMBEX, effect, succinylcholine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Infusion requirements of NIMBEX in patients administered succinylcholine prior to infusions of NIMBEX were comparable to or slightly greater than when succinylcholine was not administered.", "output": "<succinylcholine, effect, NIMBEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Isoflurane or enflurane administered with nitrous oxide/oxygen to achieve 1.25 MAC [Minimum Alveolar Concentration] may prolong the clinically effective duration of action of initial and maintenance doses of NIMBEX and decrease the required infusion rate of NIMBEX.", "output": "<Isoflurane, effect, NIMBEX>, <Isoflurane, effect, NIMBEX>, <enflurane, effect, NIMBEX>, <enflurane, effect, NIMBEX>, <nitrous oxide, effect, NIMBEX>, <nitrous oxide, effect, NIMBEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In long surgical procedures during enflurane or isoflurane anesthesia, less frequent maintenance dosing, lower maintenance doses, or reduced infusion rates of NIMBEX may be necessary.", "output": "<enflurane, advise, NIMBEX>, <isoflurane, advise, NIMBEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other drugs which may enhance the neuromuscular blocking action of nondepolarizing agents such as NIMBEX include certain antibiotics (e. g., aminoglycosides, tetracyclines, bacitracin, polymyxins, lincomycin, clindamycin, colistin, and sodium colistemethate), magnesium salts, lithium, local anesthetics, procainamide, and quinidine.", "output": "<nondepolarizing agents, effect, NIMBEX>, <nondepolarizing agents, effect, antibiotics>, <nondepolarizing agents, effect, aminoglycosides>, <nondepolarizing agents, effect, tetracyclines>, <nondepolarizing agents, effect, bacitracin>, <nondepolarizing agents, effect, polymyxins>, <nondepolarizing agents, effect, lincomycin>, <nondepolarizing agents, effect, clindamycin>, <nondepolarizing agents, effect, colistin>, <nondepolarizing agents, effect, sodium colistemethate>, <nondepolarizing agents, effect, magnesium>, <nondepolarizing agents, effect, lithium>, <nondepolarizing agents, effect, anesthetics>, <nondepolarizing agents, effect, procainamide>, <nondepolarizing agents, effect, quinidine>, <NIMBEX, effect, antibiotics>, <NIMBEX, effect, aminoglycosides>, <NIMBEX, effect, tetracyclines>, <NIMBEX, effect, bacitracin>, <NIMBEX, effect, polymyxins>, <NIMBEX, effect, lincomycin>, <NIMBEX, effect, clindamycin>, <NIMBEX, effect, colistin>, <NIMBEX, effect, sodium colistemethate>, <NIMBEX, effect, magnesium>, <NIMBEX, effect, lithium>, <NIMBEX, effect, anesthetics>, <NIMBEX, effect, procainamide>, <NIMBEX, effect, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Resistance to the neuromuscular blocking action of nondepolarizing neuromuscular blocking agents has been demonstrated in patients chronically administered phenytoin or carbamazepine.", "output": "<nondepolarizing neuromuscular blocking agents, effect, phenytoin>, <nondepolarizing neuromuscular blocking agents, effect, carbamazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "While the effects of chronic phenytoin or carbamazepine therapy on the action of NIMBEX are unknown, slightly shorter durations of neuromuscular block may be anticipated and infusion rate requirements may be higher.", "output": "<phenytoin, effect, NIMBEX>, <carbamazepine, effect, NIMBEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Starlix is a potential inhibitor of the CYP2C9 isoenzyme in vivo as indicated by its ability to inhibit the in vitro metabolism of tolbutamide.", "output": "<Starlix, mechanism, tolbutamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Certain drugs, including nonsteroidal anti-inflammatory agents (NSAIDs), salicylates, monoamine oxidase inhibitors, and non-selective beta-adrenergic-blocking agents may potentiate the hypoglycemic action of Starlix and other oral antidiabetic drugs.", "output": "<nonsteroidal anti-inflammatory agents, effect, Starlix>, <nonsteroidal anti-inflammatory agents, effect, antidiabetic drugs>, <NSAIDs, effect, Starlix>, <NSAIDs, effect, antidiabetic drugs>, <salicylates, effect, Starlix>, <salicylates, effect, antidiabetic drugs>, <monoamine oxidase inhibitors, effect, Starlix>, <monoamine oxidase inhibitors, effect, antidiabetic drugs>, <non-selective beta-adrenergic-blocking agents, effect, Starlix>, <non-selective beta-adrenergic-blocking agents, effect, antidiabetic drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Certain drugs including thiazides, corticosteroids, thyroid products, and sympathomimetics may reduce the hypoglycemic action of Starlix and other oral antidiabetic drugs.", "output": "<thiazides, effect, Starlix>, <thiazides, effect, antidiabetic drugs>, <corticosteroids, effect, Starlix>, <corticosteroids, effect, antidiabetic drugs>, <thyroid products, effect, Starlix>, <thyroid products, effect, antidiabetic drugs>, <sympathomimetics, effect, Starlix>, <sympathomimetics, effect, antidiabetic drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dexamethasone: Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in eight neurocysticercosis patients.", "output": "<dexamethasone, mechanism, albendazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Praziquantel: In the fed state, praziquantel (40 mg/kg) increased mean maximum plasma concentration and area under the curve of albendazole sulfoxide by about 50% in healthy subjects (n=10) compared with a separate group of subjects (n=6) given albendazole alone.", "output": "<praziquantel, mechanism, albendazole sulfoxide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine: Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n=7) compared with albendazole (20 mg/kg/day) alone (n=12).", "output": "<Albendazole sulfoxide, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators.", "output": "<isosorbide dinitrate, effect, vasodilators>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Inhibitors of CYP1A2: Concomitant use of duloxetine with fluvoxamine, an inhibitor of CYP1A2, results in approximately a 6-fold increase in AUC and about a 2.5-fold increase in Cmax of duloxetine.", "output": "<duloxetine, mechanism, fluvoxamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Paroxetine (20 mg QD) increased the concentration of duloxetine (40 mg QD) by about 60%, and greater degrees of inhibition are expected with higher doses of paroxetine.", "output": "<Paroxetine, mechanism, duloxetine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When duloxetine was administered (at a dose of 60 mg BID) in conjunction with a single 50-mg dose of desipramine, a CYP2D6 substrate, the AUC of desipramine increased 3-fold.", "output": "<duloxetine, mechanism, desipramine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, co-administration of Duloxetine with other drugs that are extensively metabolized by this isozyme and which have a narrow therapeutic index, including certain antidepressants (tricyclic antidepressants [TCAs], such as nortriptyline, amitriptyline, and imipramine), phenothiazines and Type 1C antiarrhythmics (e.g., propafenone, flecainide), should be approached with caution.", "output": "<Duloxetine, advise, antidepressants>, <Duloxetine, advise, tricyclic antidepressants>, <Duloxetine, advise, TCAs>, <Duloxetine, advise, nortriptyline>, <Duloxetine, advise, amitriptyline>, <Duloxetine, advise, imipramine>, <Duloxetine, advise, phenothiazines>, <Duloxetine, advise, Type 1C antiarrhythmics>, <Duloxetine, advise, propafenone>, <Duloxetine, advise, flecainide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Plasma TCA concentrations may need to be monitored and the dose of the TCA may need to be reduced if a TCA is co-administered with Duloxetine.", "output": "<TCA, advise, Duloxetine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because of the risk of serious ventricular arrhythmias and sudden death potentially associated with elevated plasma levels of thioridazine, Duloxetine and thioridazine should not be co-administered.", "output": "<Duloxetine, advise, thioridazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Naproxen: Coadministration (N=18) of naproxen sodium capsules (250 mg) with Neurontin (125 mg) appears to increase the amount of gabapentin absorbed by 12% to 15%.", "output": "<naproxen sodium, mechanism, Neurontin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hydrocodone increases gabapentin AUC values by 14%.", "output": "<Hydrocodone, mechanism, gabapentin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Morphine: A literature article reported that when a 60-mg controlled-release morphine capsule was administered 2 hours prior to a 600-mg Neurontin  capsule (N=12), mean gabapentin AUC increased by 44% compared to gabapentin administered without morphine.", "output": "<morphine, mechanism, Neurontin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine: In the presence of cimetidine at 300 mg QID (N=12) the mean apparent oral clearance of gabapentin fell by 14% and creatinine clearance fell by 10%.", "output": "<cimetidine, mechanism, gabapentin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus cimetidine appeared to alter the renal excretion of both gabapentin and creatinine, an endogenous marker of renal function.", "output": "<cimetidine, mechanism, gabapentin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This small decrease in excretion of gabapentin by cimetidine is not expected to be of clinical importance.", "output": "<gabapentin, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The Cmax of norethindrone was 13% higher when it was coadministered with gabapentin;", "output": "<norethindrone, mechanism, gabapentin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacid (Maalox ): Maalox reduced the bioavailability of gabapentin (N=16) by about 20%.", "output": "<Maalox, mechanism, gabapentin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This decrease in bioavailability was about 5% when gabapentin was administered 2 hours after Maalox.", "output": "<gabapentin, mechanism, Maalox>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended that gabapentin be taken at least 2 hours following Maalox administration.", "output": "<gabapentin, advise, Maalox>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is, however, possible that concomitant use of other known photosensitizing agents such as griseofulvin, thiazide diuretics, sulfonylureas, phenothiazines, sulfonamides and tetracyclines might increase the photosensitivity reaction of actinic keratoses treated with the LEVULAN KERASTICK for Topical Solution.", "output": "<photosensitizing agents, effect, LEVULAN KERASTICK>, <griseofulvin, effect, LEVULAN KERASTICK>, <thiazide diuretics, effect, LEVULAN KERASTICK>, <sulfonylureas, effect, LEVULAN KERASTICK>, <phenothiazines, effect, LEVULAN KERASTICK>, <sulfonamides, effect, LEVULAN KERASTICK>, <tetracyclines, effect, LEVULAN KERASTICK>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Zalcitabine also has no significant effect on the intracellular phosphorylation of ZDV, as shown in vitro in peripheral blood mononuclear cells or in two other cell lines (U937 and Molt-4).", "output": "<Zalcitabine, effect, ZDV>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lamivudine: In vitro studies in peripheral blood mononuclear cells, U937 and Molt-4 cells revealed that lamivudine significantly inhibited zalcitabine phosphorylation in a dose dependent manner.", "output": "<lamivudine, effect, zalcitabine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Zalcitabine inhibited lamivudine phosphorylation at high concentration ratios (10 and 100);", "output": "<Zalcitabine, effect, lamivudine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "These in vitro studies suggest that concomitant administration of zalcitabine and lamivudine in humans may result in sub-therapeutic concentrations of active phosphorylated zalcitabine, which may lead to a decreased antiretroviral effect of zalcitabine.", "output": "<zalcitabine, effect, lamivudine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of zalcitabine and lamivudine is not recommended.", "output": "<zalcitabine, advise, lamivudine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of HIVID with didanosine is not recommended.", "output": "<HIVID, advise, didanosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Death due to fulminant pancreatitis possibly related to intravenous pentamidine and HIVID has been reported.", "output": "<pentamidine, effect, HIVID>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If intravenous pentamidine is required to treat Pneumocystis carinii pneumonia, treatment with HIVID should be interrupted.", "output": "<pentamidine, advise, HIVID>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Amphotericin, Foscarnet, and Aminoglycosides: Drugs such as amphotericin, foscarnet, and aminoglycosides may increase the risk of developing peripheral neuropathy or other HIVID-associated adverse events by interfering with the renal clearance of zalcitabine (thereby raising systemic exposure).", "output": "<amphotericin, effect, HIVID>, <amphotericin, mechanism, zalcitabine>, <foscarnet, effect, HIVID>, <foscarnet, mechanism, zalcitabine>, <aminoglycosides, effect, HIVID>, <aminoglycosides, mechanism, zalcitabine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid or Cimetidine: Concomitant administration of probenecid or cimetidine decreases the elimination of zalcitabine, most likely by inhibition of renal tubular secretion of zalcitabine.", "output": "<probenecid, mechanism, zalcitabine>, <cimetidine, mechanism, zalcitabine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The clinical significance of this reduction is not known, hence zalcitabine is not recommended to be ingested simultaneously with magnesium/aluminum-containing antacids.", "output": "<zalcitabine, advise, magnesium>, <zalcitabine, advise, aluminum>, <zalcitabine, advise, antacids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Metoclopramide: Bioavailability is mildly reduced (approximately 10%) when zalcitabine and metoclopramide are coadministered.", "output": "<zalcitabine, mechanism, metoclopramide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Doxorubicin: Doxorubicin caused a decrease in zalcitabine phosphorylation ( 50% inhibition of total phosphate formation) in U937/Molt 4 cells.", "output": "<Doxorubicin, effect, zalcitabine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acidifying agents: Gastrointestinal acidifying agents (guanethidine, reserpine, glutamic acid HCl, ascorbic acid, fruit juices, etc.) lower absorption of amphetamines.", "output": "<Gastrointestinal acidifying agents, mechanism, amphetamines>, <guanethidine, mechanism, amphetamines>, <reserpine, mechanism, amphetamines>, <glutamic acid HCl, mechanism, amphetamines>, <ascorbic acid, mechanism, amphetamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Urinary acidifying agents (ammonium chloride, sodium acid phosphate, etc.) increase the concentration of the ionized species of the amphetamine molecule, thereby increasing urinary excretion.", "output": "<Urinary acidifying agents, mechanism, amphetamine>, <ammonium chloride, mechanism, amphetamine>, <sodium acid phosphate, mechanism, amphetamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Adrenergic blockers: Adrenergic blockers are inhibited by amphetamines.", "output": "<Adrenergic blockers, effect, amphetamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Alkalinizing agents: Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines.", "output": "<sodium bicarbonate, mechanism, amphetamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion.", "output": "<acetazolamide, mechanism, amphetamine>, <thiazides, mechanism, amphetamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antidepressants, tricyclic: Amphetamines may enhance the activity of tricyclic or sympathomimetic agents;", "output": "<Amphetamines, effect, tricyclic>, <Amphetamines, effect, sympathomimetic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain;", "output": "<d-amphetamine, mechanism, desipramine>, <d-amphetamine, mechanism, protriptyline>, <d-amphetamine, mechanism, tricyclics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "MAO inhibitors: MAOI antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism.", "output": "<MAOI antidepressants, mechanism, amphetamine>, <furazolidone, mechanism, amphetamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antihistamines: Amphetamines may counteract the sedative effect of antihistamines.", "output": "<Amphetamines, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antihypertensives: Amphetamines may antagonize the hypotensive effects of antihypertensives.", "output": "<Amphetamines, effect, antihypertensives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chlorpromazine: Chlorpromazine blocks dopamine and norepinephrine reuptake, thus inhibiting the central stimulant effects of amphetamines, and can be used to treat amphetamine poisoning.", "output": "<Chlorpromazine, effect, amphetamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ethosuximide: Amphetamines may delay intestinal absorption of ethosuximide.", "output": "<Amphetamines, mechanism, ethosuximide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Haloperidol: Haloperidol blocks dopamine and norepinephrine reuptake, thus inhibiting the central stimulant effects of amphetamines.", "output": "<Haloperidol, effect, amphetamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium carbonate: The stimulatory effects of amphetamines may be inhibited by lithium carbonate.", "output": "<amphetamines, effect, lithium carbonate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Meperidine: Amphetamines potentiate the analgesic effect of meperidine.", "output": "<Amphetamines, effect, meperidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methenamine therapy: Urinary excretion of amphetamines is increased, and efficacy is reduced, by acidifying agents used in methenamine therapy.", "output": "<amphetamines, mechanism, acidifying agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Norepinephrine: Amphetamines enhance the adrenergic effect of norepinephrine.", "output": "<Amphetamines, effect, norepinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenobarbital: Amphetamines may delay intestinal absorption of phenobarbital;", "output": "<Amphetamines, mechanism, phenobarbital>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin: Amphetamines may delay intestinal absorption of phenytoin;", "output": "<Amphetamines, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Propoxyphene: In cases of propoxyphene overdosage, amphetamine CNS stimulation is potentiated and fatal convulsions can occur.", "output": "<propoxyphene, effect, amphetamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Veratrum alkaloids: Amphetamines inhibit the hypotensive effect of veratrum alkaloids.", "output": "<Amphetamines, effect, veratrum alkaloids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of loratadine relative to that observed with erythromycin alone.", "output": "<erythromycin, mechanism, loratadine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tablet If a patient receiving clonidine hydrochloride is also taking tricyclic antidepressants, the effect of clonidine may be reduced, thus necessitating an increase in dosage.", "output": "<clonidine hydrochloride, effect, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Clonidine hydrochloride may enhance the CNS-depressive effects of alcohol, barbiturates or other sedatives.", "output": "<Clonidine hydrochloride, effect, alcohol>, <Clonidine hydrochloride, effect, barbiturates>, <Clonidine hydrochloride, effect, sedatives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats Epidural Injection Clonidine may potentiate the CNS-depressive effect of alcohol, barbiturates or other sedating drugs.", "output": "<Amitriptyline, effect, clonidine>, <Clonidine, effect, alcohol>, <Clonidine, effect, barbiturates>, <Clonidine, effect, sedating drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Narcotic analgesics may potentiate the hypotensive effects of clonidine.", "output": "<Narcotic analgesics, effect, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tricyclic antidepressants may antagonize the hypotensive effects of clonidine.", "output": "<Tricyclic antidepressants, effect, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta blockers may exacerbate the hypertensive response seen with clonidine withdrawl.", "output": "<Beta blockers, effect, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Also, due to the potential for additive effects such as bradycardia and AV block, caution is warranted in patients receiving clonidine with agents known to affect sinus node function or AV nodal conduction (e.g., digitalis, calcium channel blockers, and beta-blockers.)", "output": "<clonidine, advise, digitalis>, <clonidine, advise, calcium channel blockers>, <clonidine, advise, beta-blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There is one reported case of a patient with acute delirium associated with the simultaneous use of fluphenazine and oral clonidine.", "output": "<fluphenazine, effect, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Epidural clonidine may prolong the duration of pharmacologic effects of epidural local anesthetics, including both sensory and motor blockade.", "output": "<clonidine, effect, anesthetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition, several AED s that are cytochrome P450 inducers can decrease plasma concentrations of oxcarbazepine and MHD.", "output": "<AED, mechanism, oxcarbazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "1- nc denotes a mean change of less than 10% 2- Pediatrics 3- Mean increase in adults at high Trileptal doses In vivo, the plasma levels of phenytoin increased by up to 40%, when Trileptal was given at doses above 1200 mg/day.", "output": "<phenytoin, mechanism, Trileptal>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, when using doses of Trileptal greater than 1200 mg/day during adjunctive therapy, a decrease in the dose of phenytoin may be required.", "output": "<Trileptal, advise, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The increase of phenobarbital level, however, is small (15%) when given with Trileptal.", "output": "<phenobarbital, mechanism, Trileptal>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hormonal contraceptives Co-administration of Trileptal with an oral contraceptive has been shown to influence the plasma concentrations of the two hormonal components, ethinylestradiol (EE) and levonorgestrel (LNG).", "output": "<Trileptal, mechanism, contraceptive>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, concurrent use of Trileptal with hormonal contraceptives may render these contraceptives less effective.", "output": "<Trileptal, effect, hormonal contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Calcium Antagonists: After repeated co-administration of Trileptal, the AUC of felodipine was lowered by 28% [90% CI: 20-33].", "output": "<Trileptal, mechanism, felodipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with dihydrotachysterol may cause hypercalcemia.", "output": "<thiazide diuretics, effect, dihydrotachysterol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Lofexidine may enhance the CNS depressive effects of alcohol, barbiturates and other sedatives", "output": "<Lofexidine, effect, alcohol>, <Lofexidine, effect, barbiturates>, <Lofexidine, effect, sedatives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Lofexidine may enhance the effects of anti-hypertensive drug therapy", "output": "<Lofexidine, effect, anti-hypertensive drug>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Concomitant use of tricyclic antidepressants may reduce the efficacy of lofexidine.", "output": "<tricyclic antidepressants, effect, lofexidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although the clinical significance is not known, it is not recommended that cefditoren pivoxil be taken concomitantly with antacids.", "output": "<cefditoren pivoxil, advise, antacids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "H2-Receptor Antagonists: Co-administration of a single dose of intravenously administered famotidine (20 mg) reduced the oral absorption of a single 400 mg dose of cefditoren pivoxil administered following a meal, as evidenced by a 27% decrease in mean Cmax and a 22% decrease in mean AUC.", "output": "<famotidine, mechanism, cefditoren pivoxil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid: As with other b-lactam antibiotics, co-administration of probenecid with cefditoren pivoxil resulted in an increase in the plasma exposure of cefditoren, with a 49% increase in mean Cmax, a 122% increase in mean AUC, and a 53% increase in half-life.", "output": "<b-lactam antibiotics, mechanism, cefditoren pivoxil>, <probenecid, mechanism, cefditoren pivoxil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When atropine and pralidoxime are used together, the signs of atropinization (flushing, mydriasis, tachycardia, dryness of the mouth and nose) may occur earlier than might be expected than when atropine is used alone because pralidoxime may potentiate the effect of atropine.", "output": "<atropine, effect, pralidoxime>, <pralidoxime, effect, atropine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The following precautions should be kept in mind in the treatment of anticholinesterase poisoning although they do not bear directly on the use of atropine and pralidoxime.", "output": "<atropine, advise, pralidoxime>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since barbiturates are potentiated by the anticholinesterases, they should be used cautiously in the treatment of convulsions.", "output": "<barbiturates, advise, anticholinesterases>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ocupress should be used with caution in patients who are receiving a beta-adrenergic blocking agent orally because of the potential for additive effects on systemic beta-blockade.", "output": "<Ocupress, advise, beta-adrenergic blocking agent>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may produce vertigo, syncope, or postural hypotension.", "output": "<beta-blocker, advise, reserpine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although specific studies have not been performed, coadministration with drugs that are mainly metabolized by CYP3A4 (eg, calcium channel blockers, dapsone, disopyramide, quinine, amiodarone, quinidine, warfarin, tacrolimus, cyclosporine, ergot derivatives, pimozide, carbamazepine, fentanyl, alfentanyl, alprazolam, and triazolam) may have elevated plasma concentrations when coadministered with saquinavir;", "output": "<calcium channel blockers, mechanism, saquinavir>, <dapsone, mechanism, saquinavir>, <disopyramide, mechanism, saquinavir>, <quinine, mechanism, saquinavir>, <amiodarone, mechanism, saquinavir>, <quinidine, mechanism, saquinavir>, <warfarin, mechanism, saquinavir>, <tacrolimus, mechanism, saquinavir>, <cyclosporine, mechanism, saquinavir>, <ergot derivatives, mechanism, saquinavir>, <pimozide, mechanism, saquinavir>, <carbamazepine, mechanism, saquinavir>, <fentanyl, mechanism, saquinavir>, <alfentanyl, mechanism, saquinavir>, <alprazolam, mechanism, saquinavir>, <triazolam, mechanism, saquinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since INVIRASE is coadministered with ritonavir, the ritonavir label should be reviewed for additional drugs that should not be coadministered.", "output": "<INVIRASE, advise, ritonavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration with compounds that are potent inducers of CYP3A4 (eg, phenobarbital, phenytoin, dexamethasone, carbamazepine) may result in decreased plasma levels of saquinavir.", "output": "<phenobarbital, mechanism, saquinavir>, <phenytoin, mechanism, saquinavir>, <dexamethasone, mechanism, saquinavir>, <carbamazepine, mechanism, saquinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In vitro mixing of an aminoglycoside with beta-lactamtype antibiotics (penicillins or cephalosporins) may result in a significant mutual inactivation.", "output": "<aminoglycoside, effect, antibiotics>, <aminoglycoside, effect, penicillins>, <aminoglycoside, effect, cephalosporins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Even when an aminoglycoside and a penicillin-type drug are administered separately by different routes, a reduction in aminoglycoside serum half-life or serum levels has been reported in patients with impaired renal function and in some patients with normal renal function.", "output": "<aminoglycoside, mechanism, penicillin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ethanol:Clinical evidence has shown that etretinate can be formed with concurrent ingestion of acitretin and ethanol.", "output": "<acitretin, mechanism, ethanol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Glibenclamide: In a study of 7 healthy male volunteers, acitretin treatment potentiated the blood glucose lowering effect of glibenclamide (a sulfonylurea similar to chlorpropamide) in 3 of the 7 subjects.", "output": "<acitretin, effect, glibenclamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, it has been established that acitretin interferes with the contraceptive effect of microdosed progestin minipill preparations.", "output": "<acitretin, effect, progestin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Microdosed minipill progestin preparations are not recommended for use with Soriatane.", "output": "<progestin, advise, Soriatane>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methotrexate: An increased risk of hepatitis has been reported to result from combined use of methotrexate and etretinate.", "output": "<methotrexate, effect, etretinate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Consequently, the combination of methotrexate with acitretin is also contraindicated.", "output": "<methotrexate, advise, acitretin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin: If acitretin is given concurrently with phenytoin, the protein binding of phenytoin may be reduced.", "output": "<acitretin, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tetracyclines: Since both acitretin and tetracyclines can cause increased intracranial pressure, their combined use is contraindicated.", "output": "<acitretin, effect, tetracyclines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Vitamin A and oral retinoids: Concomitant administration of vitamin A and/or other oral retinoids with acitretin must be avoided because of the risk of hypervitaminosis A.", "output": "<vitamin A, advise, acitretin>, <retinoids, advise, acitretin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Use of Cerubidine in a patient who has previously received doxorubicin increases the risk of cardiotoxicity.", "output": "<Cerubidine, effect, doxorubicin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cerubidine should not be used in patients who have previously received the recommended maximum cumulative doses of doxorubicin or Cerubidine.", "output": "<Cerubidine, advise, doxorubicin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclophosphamide used concurrently with Cerubidine may also result in increased cardiotoxicity.", "output": "<Cyclophosphamide, effect, Cerubidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, the concomitant use of Argatroban and warfarin (5-7.5 mg initial oral dose followed by 2.5-6 mg/day orally for 6-10 days) results in prolongation of the prothrombin time (PT) and International Normalized Ratio (INR).", "output": "<Argatroban, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration: Concomitant use of Argatroban with antiplatelet agents, thrombolytics, and other anticoagulants may increase the risk of bleeding.", "output": "<Argatroban, effect, antiplatelet agents>, <Argatroban, effect, thrombolytics>, <Argatroban, effect, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors.", "output": "<NSAIDs, effect, Angiotensin Converting Enzyme (ACE) inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients with mild to moderate hypertension, administration of 25 mg daily of VIOXX with the ACE inhibitor benazepril, 10 to 40 mg for 4 weeks, was associated with an average increase in mean arterial pressure of about 3 mm Hg compared to ACE inhibitor alone.", "output": "<VIOXX, effect, benazepril>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This interaction should be given consideration in patients taking VIOXX concomitantly with ACE inhibitors.", "output": "<VIOXX, advise, ACE inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: Concomitant administration of low-dose aspirin with VIOXX may result in an increased rate of GI ulceration or other complications, compared to use of VIOXX alone.", "output": "<aspirin, effect, VIOXX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine: Co-administration with high doses of cimetidine [800 mg twice daily] increased the Cmax of rofecoxib by 21%, the AUC0-120hr by 23% and the t1/2 by 15%.", "output": "<cimetidine, mechanism, rofecoxib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide: Clinical studies, as well as post-marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.", "output": "<NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.", "output": "<NSAIDs, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus, when VIOXX and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.", "output": "<VIOXX, advise, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "At higher than recommended doses, VIOXX 75 mg administered once daily for 10 days increased plasma concentrations by 23% as measured by AUC0-24hr in patients receiving methotrexate 7.5 to 15 mg/week for rheumatoid arthritis.", "output": "<VIOXX, mechanism, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "At 24 hours postdose, a similar proportion of patients treated with methotrexate alone (94%) and subsequently treated with methotrexate co-administered with 75 mg of rofecoxib (88%) had methotrexate plasma concentrations below the measurable limit (5 ng/mL).", "output": "<methotrexate, mechanism, rofecoxib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Standard monitoring of methotrexate-related toxicity should be continued if VIOXX and methotrexate are administered concomitantly.", "output": "<VIOXX, advise, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rifampin: Co-administration of VIOXX with rifampin 600 mg daily, a potent inducer of hepatic metabolism, produced an approximate 50% decrease in rofecoxib plasma concentrations.", "output": "<VIOXX, mechanism, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Theophylline VIOXX 12.5, 25, and 50 mg administered once daily for 7 days increased plasma theophylline concentrations (AUC(0- )) by 38 to 60% in healthy subjects administered a single 300-mg dose of theophylline.", "output": "<VIOXX, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Adequate monitoring of theophylline plasma concentrations should be considered when therapy with VIOXX is initiated or changed in patients receiving theophylline.", "output": "<VIOXX, advise, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin: Anticoagulant activity should be monitored, particularly in the first few days after initiating or changing VIOXX therapy in patients receiving warfarin or similar agents, since these patients are at an increased risk of bleeding complications.", "output": "<VIOXX, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In single and multiple dose studies in healthy subjects receiving both warfarin and rofecoxib, prothrombin time (measured as INR) was increased by approximately 8% to 11%.", "output": "<warfarin, effect, rofecoxib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In post-marketing experience, bleeding events have been reported, predominantly in the elderly, in association with increases in prothrombin time in patients receiving VIOXX concurrently with warfarin.", "output": "<VIOXX, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "DOSTINEX should not be administered concurrently with D2-antagonists, such as phenothiazines, butyrophenones, thioxanthines, or metoclopramide.", "output": "<DOSTINEX, advise, phenothiazines>, <DOSTINEX, advise, butyrophenones>, <DOSTINEX, advise, thioxanthines>, <DOSTINEX, advise, metoclopramide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When lansoprazole was administered concomitantly with theophylline (CYP1A2, CYP3A), a minor increase (10%) in the clearance of theophylline was seen.", "output": "<lansoprazole, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nonetheless, individual patients may require additional titration of their theophylline dosage when lansoprazole is started or stopped to ensure clinically effective blood levels.", "output": "<theophylline, advise, lansoprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a single-dose crossover study examining lansoprazole 30 mg and omeprazole 20 mg each administered alone and concomitantly with sucralfate 1 gram, absorption of the proton pump inhibitors was delayed and their bioavailability was reduced by 17% and 16%, respectively, when administered concomitantly with sucralfate.", "output": "<proton pump inhibitors, mechanism, sucralfate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, proton pump inhibitors should be taken at least 30 minutes prior to sucralfate.", "output": "<proton pump inhibitors, advise, sucralfate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "therefore, it is theoretically possible that lansoprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g. ketoconazole, ampicillin esters, iron salts, digoxin).", "output": "<lansoprazole, mechanism, ketoconazole>, <lansoprazole, mechanism, ampicillin>, <lansoprazole, mechanism, iron>, <lansoprazole, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Considerable caution should be exercised if PEGANONE is administered concurrently with Phenurone (phenacemide) since paranoid symptoms have been reported during therapy with this combination.", "output": "<PEGANONE, advise, Phenurone>, <PEGANONE, advise, phenacemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A two-way interaction between the hydantoin antiepileptic, phenytoin, and the coumarin anticoagulants has been suggested.", "output": "<hydantoin antiepileptic, int, phenytoin>, <hydantoin antiepileptic, int, coumarin anticoagulant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Presumably, phenytoin acts as a stimulator of coumarin metabolism and has been reported to cause decreased serum levels of the coumarin anticoagulants and increased prothrombin-proconvertin concentrations.", "output": "<phenytoin, mechanism, coumarin>, <phenytoin, mechanism, coumarin anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Conversely, the coumarin anticoagulants have been reported to increase the serum levels and prolong the serum half-life of phenytoin by inhibiting its metabolism.", "output": "<coumarin anticoagulants, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution is therefore advised when administering PEGANONE to patients receiving coumarin anticoagulants.", "output": "<PEGANONE, advise, coumarin anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients on warfarin-type anticoagulant therapy may require dosage adjustment of the anticoagulant during and after griseofulvin therapy.", "output": "<warfarin-type anticoagulant, advise, griseofulvin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of barbiturates usually depresses griseofulvin activity and may necessitate raising the dosage.", "output": "<barbiturates, effect, griseofulvin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant administration of griseofulvin has been reported to reduce the efficacy of oral contraceptives and to increase the incidence of breakthrough bleeding.", "output": "<griseofulvin, effect, contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid : Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, angiotensin-converting enzyme inhibitors, aminosalicylic acid, barbiturates, benzodiazepines, bumetanide, clofibrate, methotrexate, famotidine, furosemide, nonsteroidal anti-inflammatory agents, theophylline, and zidovudine).", "output": "<Probenecid, mechanism, acetaminophen>, <Probenecid, mechanism, acyclovir>, <Probenecid, mechanism, angiotensin-converting enzyme inhibitors>, <Probenecid, mechanism, aminosalicylic acid>, <Probenecid, mechanism, barbiturates>, <Probenecid, mechanism, benzodiazepines>, <Probenecid, mechanism, bumetanide>, <Probenecid, mechanism, clofibrate>, <Probenecid, mechanism, methotrexate>, <Probenecid, mechanism, famotidine>, <Probenecid, mechanism, furosemide>, <Probenecid, mechanism, nonsteroidal anti-inflammatory>, <Probenecid, mechanism, theophylline>, <Probenecid, mechanism, zidovudine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Zidovudine should either be temporarily discontinued or decreased by 50% when coadministered with probenecid on the day of VISTIDE infusion.", "output": "<Zidovudine, advise, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nephrotoxic agents : Concomitant administration of VISTIDE and agents with nephrotoxic potential [e.g., intravenous aminoglycosides (e.g., tobramycin, gentamicin, and amikacin), amphotericin B, foscarnet, intravenous pentamidine, vancomycin, and non-steroidal anti-inflammatory agents] is contraindicated.", "output": "<VISTIDE, advise, aminoglycosides>, <VISTIDE, advise, tobramycin>, <VISTIDE, advise, gentamicin>, <VISTIDE, advise, amikacin>, <VISTIDE, advise, amphotericin B>, <VISTIDE, advise, foscarnet>, <VISTIDE, advise, pentamidine>, <VISTIDE, advise, vancomycin>, <VISTIDE, advise, non-steroidal anti-inflammatory agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, interactions may be expected, and UROXATRAL should NOT be used in combination with other alpha-blockers.", "output": "<UROXATRAL, advise, alpha-blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dimenhydrinate may decrease emetic response to apomorphine.", "output": "<Dimenhydrinate, effect, apomorphine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticoagulants including coumarin derivatives, indandione derivatives, and platelet aggregation inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs), and aspirin may increase the risk of bleeding when administered concomitantly with ardeparin.", "output": "<Anticoagulants, effect, ardeparin>, <platelet aggregation inhibitors, effect, ardeparin>, <nonsteroidal anti-inflammatory drugs, effect, ardeparin>, <NSAIDs, effect, ardeparin>, <aspirin, effect, ardeparin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins;", "output": "<Cholestyramine, mechanism, fat soluble vitamins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin/Phenobarbital: The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism.", "output": "<phenytoin, mechanism, calcitriol>, <phenobarbital, mechanism, calcitriol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia.", "output": "<thiazides, effect, vitamin D>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias.", "output": "<Vitamin D, advise, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D.", "output": "<Ketoconazole, mechanism, vitamin D>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.", "output": "<vitamin D analogues, mechanism, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.", "output": "<Magnesium, advise, vitamin D>, <antacids, advise, vitamin D>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ERGAMISOL  (levamisole hydrochloride) has been reported to produce ANTABUSE-like side effects when given concomitantly with alcohol.", "output": "<ERGAMISOL, effect, alcohol>, <levamisole hydrochloride, effect, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because of reports of prolongation of the prothrombin time beyond the therapeutic range in patients taking concurrent levamisole and warfarin sodium, it is suggested that the prothrombin time be monitored carefully, and the dose of warfarin sodium or other coumarin-like drugs should be adjusted accordingly, in patients taking both drugs.", "output": "<levamisole, advise, warfarin sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Use with Allopurinol: The principal pathway for detoxification of azathioprine is inhibited by allopurinol.", "output": "<azathioprine, mechanism, allopurinol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients receiving azathioprine and allopurinol concomitantly should have a dose reduction of azathioprine, to approximately 1/3 to 1/4 the usual dose.", "output": "<azathioprine, advise, allopurinol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Use with Angiotensln Converting Enzyme Inhibitors: The use of angiotensin converting enzyme inhibitors to control hypertension in patients on azathioprine has been reported to induce severe leukopenia.", "output": "<angiotensin converting enzyme inhibitors, effect, azathioprine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Alcohol - Although LEXAPRO did not potentiate the cognitive and motor effects of alcohol in a clinical trial, as with other psychotropic medications, the use of alcohol by patients taking LEXAPRO is not recommended.", "output": "<psychotropic medications, advise, LEXAPRO>, <alcohol, advise, LEXAPRO>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin potentiated the risk of bleeding.", "output": "<psychotropic drugs, effect, NSAID>, <psychotropic drugs, effect, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine - In subjects who had received 21 days of 40 mg/day racemic citalopram, combined administration of 400 mg/day cimetidine for 8 days resulted in an increase in citalopram AUC and Cmax of 43% and 39%, respectively.", "output": "<citalopram, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because lithium may enhance the serotonergic effects of escitalopram, caution should be exercised when LEXAPRO and lithium are coadministered.", "output": "<lithium, effect, escitalopram>, <LEXAPRO, advise, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pimozide and Celexa - In a controlled study, a single dose of pimozide 2 mg co-administered with racemic citalopram 40 mg given once daily for 11 days was associated with a mean increase in QTc values of approximately 10 msec compared to pimozide given alone.", "output": "<pimozide, effect, citalopram>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sumatriptan - There have been rare postmarketing reports describing patients with weakness, hyperreflexia, and incoordination following the use of a selective serotonin reuptake inhibitor (SSRI) and sumatriptan.", "output": "<selective serotonin reuptake inhibitor, effect, sumatriptan>, <SSRI, effect, sumatriptan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If concomitant treatment with sumatriptan and an SSRI (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, escitalopram) is clinically warranted, appropriate observation of the patient is advised.", "output": "<sumatriptan, advise, SSRI>, <sumatriptan, advise, fluoxetine>, <sumatriptan, advise, fluvoxamine>, <sumatriptan, advise, paroxetine>, <sumatriptan, advise, sertraline>, <sumatriptan, advise, citalopram>, <sumatriptan, advise, escitalopram>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although trough citalopram plasma levels were unaffected, given the enzyme-inducing properties of carbamazepine, the possibility that carbamazepine might increase the clearance of escitalopram should be considered if the two drugs are coadministered.", "output": "<carbamazepine, mechanism, escitalopram>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole - Combined administration of racemic citalopram (40 mg) and ketoconazole (200 mg) decreased the Cmax and AUC of ketoconazole by 21% and 10%, respectively, and did not significantly affect the pharmacokinetics of citalopram.", "output": "<citalopram, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, there are limited in vivo data suggesting a modest CYP2D6 inhibitory effect for escitalopram, i.e., coadministration of escitalopram (20 mg/day for 21 days) with the tricyclic antidepressant desipramine (single dose of 50 mg), a substrate for CYP2D6, resulted in a 40% increase in Cmax and a 100% increase in AUC of desipramine.", "output": "<escitalopram, mechanism, desipramine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Metoprolol - Administration of 20 mg/day LEXAPRO for 21 days in healthy volunteers resulted in a 50% increase in Cmax and 82% increase in AUC of the beta-adrenergic blocker metoprolol (given in a single dose of 100 mg).", "output": "<LEXAPRO, mechanism, metoprolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant Administration with Racemic Citalopram Citalopram - Since escitalopram is the active isomer of racemic citalopram (Celexa), the two agents should not be coadministered.", "output": "<escitalopram, advise, citalopram>, <escitalopram, advise, Celexa>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cytadren accelerates the metabolism of dexamethasone;", "output": "<Cytadren, mechanism, dexamethasone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aminoglutethimide diminishes the effect of coumarin and warfarin.", "output": "<Aminoglutethimide, effect, coumarin>, <Aminoglutethimide, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, appropriate monitoring of blood glucose should be performed when initiating EXTRANEAL in diabetic patients and insulin dosage should be adjusted if needed.", "output": "<EXTRANEAL, advise, insulin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The hypotensive effect of sodium nitroprusside is augmented by that of most other hypotensive drugs, including ganglionic blocking agents, negative inotropic agents, and inhaled anesthetics.", "output": "<sodium nitroprusside, effect, hypotensive drugs>, <sodium nitroprusside, effect, ganglionic blocking agents>, <sodium nitroprusside, effect, anesthetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "CNS-Active Drugs Ethanol An additive effect on psychomotor performance was seen with coadministration of eszopiclone and ethanol 0.70 g/kg for up to 4 hours after ethanol administration.", "output": "<eszopiclone, effect, ethanol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Olanzapine: Coadministration of eszopiclone 3 mg and olanzapine 10 mg produced a decrease in DSST scores.", "output": "<eszopiclone, effect, olanzapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The AUC of eszopiclone was increased 2.2-fold by coadministration of ketoconazole, a potent inhibitor of CYP3A4, 400 mg daily for 5 days.", "output": "<eszopiclone, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs That Induce CYP3A4 (Rifampicin) Racemic zopiclone exposure was decreased 80% by concomitant useof rifampicin, a potent inducer of CYP3A4.", "output": "<zopiclone, mechanism, rifampicin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents.", "output": "<Clindamycin, effect, neuromuscular blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antagonism has been demonstrated between clindamycin and erythromycin in vitro.", "output": "<clindamycin, effect, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of other sympathomimetic agents may potentiate the undesirable effects of FORADIL.", "output": "<sympathomimetic agents, effect, FORADIL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Monoamine Oxidase Inhibitors and Tricyclic Antidepressants: FORADIL should be administered with extreme caution in patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants because the action of formoterol on the cardiovascular system may be potentiated by these agents.", "output": "<FORADIL, advise, monoamine oxidase inhibitors>, <FORADIL, advise, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticosteroids, Methylxanthines and Diuretics: Concomitant treatment with xanthine derivatives, steroids, or diuretics may potentiate a possible hypokalemic effect of  beta2-agonists.", "output": "<xanthine derivatives, effect, beta2-agonists.>, <steroids, effect, beta2-agonists.>, <diuretics, effect, beta2-agonists.>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "During administration of multiple oral doses of TAMBOCOR to healthy subjects stabilized on a maintenance dose of digoxin, a 13%-19% increase in plasma digoxin levels occurred at six hours postdose.", "output": "<TAMBOCOR, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a study involving healthy subjects receiving TAMBOCOR and propranolol concurrently, plasma flecainide levels were increased about 20% and propranolol levels were increased about 30% compared to control values.", "output": "<TAMBOCOR, mechanism, propranolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The effects of concomitant administration of TAMBOCOR and propranolol on the PR interval were less than additive.", "output": "<TAMBOCOR, effect, propranolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nevertheless, the possibility of additive negative inotropic effects of beta blockers and flecainide should be recognized.", "output": "<beta blockers, effect, flecainide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Limited data in patients receiving known enzyme inducers ( phenytoin, phenobarbital, carbamazepine ) indicate only a 30% increase in the rate of flecainide elimination.", "output": "<phenytoin, mechanism, flecainide>, <phenobarbital, mechanism, flecainide>, <carbamazepine, mechanism, flecainide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In healthy subjects receiving cimetidine (1 gm daily) for one week, plasma flecainide levels increased by about 30% and half-life increased by about 10%.", "output": "<cimetidine, mechanism, flecainide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When amiodarone is added to flecainide therapy, plasma flecainide levels may increase two-fold or more in some patients, if flecainide dosage is not reduced.", "output": "<amiodarone, mechanism, flecainide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that inhibit cytochrome P450IID6, such as quinidine , might increase the plasma concentrations of flecainide in patients that are on chronic flecainide therapy;", "output": "<quinidine, mechanism, flecainide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because both of these drugs have negative inotropic properties and the effects of coadministration with TAMBOCOR are unknown, neither disopyramide nor verapamil should be administered concurrently with TAMBOCOR unless, in the judgment of the physician, the benefits of this combination outweigh the risks.", "output": "<disopyramide, advise, TAMBOCOR>, <verapamil, advise, TAMBOCOR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be observed when anileridine is coadministered with other opioids, sedatives, phenothiazines, or anesthetics, as these agents may increase respiratory and circulatory depression.", "output": "<anileridine, advise, opioids>, <anileridine, advise, sedatives>, <anileridine, advise, phenothiazines>, <anileridine, advise, anesthetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Vasoconstrictors: D.H.E. 45  (dihydroergotamine mesylate) Injection, USP should not be used with peripheral vasoconstrictors because the combination may cause synergistic elevation of blood pressure.", "output": "<D.H.E. 45, effect, peripheral vasoconstrictors>, <dihydroergotamine mesylate, effect, peripheral vasoconstrictors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sumatriptan: Sumatriptan has been reported to cause coronary artery vasospasm, and its effect could be additive with D.H.E. 45  (dihydroergotamine mesylate) Injection, USP.", "output": "<Sumatriptan, effect, D.H.E. 45>, <Sumatriptan, effect, dihydroergotamine mesylate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sumatriptan and D.H.E. 45  (dihydroergotamine mesylate) Injection, USP should not be taken within 24 hours of each other..", "output": "<Sumatriptan, advise, D.H.E. 45>, <Sumatriptan, advise, dihydroergotamine mesylate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta Blockers: Although the results of a clinical study did not indicate a safe problem associated with the administration of D.H.E. 45  (dihydroergotamine mesylate) Injection, USP to subjects already receiving propranolol, there have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine.", "output": "<propranolol, effect, ergotamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nicotine: Nicotine may provoke vasoconstriction in some patients, predisposing to a greater ischemic response to ergot therapy.", "output": "<Nicotine, effect, ergot>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Macrolide Antibiotics (e. g. erythromycin and troleandomycin): Agents of the ergot alkaloid class, of which D.H.E. 45  (dihydroergotamine mesylate) Injection, USP is a member, have been shown to interact with antibiotics of the macrolide class, resulting in increased plasma levels of unchanged alkaloids and peripheral vasoconstriction.", "output": "<ergot alkaloid class, mechanism, macrolide class>, <D.H.E. 45, mechanism, macrolide class>, <dihydroergotamine mesylate, mechanism, macrolide class>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Vasospastic reactions have been reported with therapeutic doses of ergotamine-containing drugs when co-administered with these antibiotics.", "output": "<ergotamine, effect, antibiotics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "SSRIs: Weakness hyperreflexia, and incoordination have been reported rarely when 5-HT1 agonists have been co-administered with SSRIs (e. g.", "output": "<5-HT1 agonists, effect, SSRIs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a study in which patients with active RA were treated for up to 24 weeks with concurrent Kineret and etanercept therapy, a 7% rate of serious infections was observed, which was higher than that observed with etanercept alone (0%).", "output": "<Kineret, effect, etanercept>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Two percent of patients treated concurrently with Kineret and etanercept developed neutropenia (ANC  1 x 109/L).", "output": "<Kineret, effect, etanercept>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "With oral dapsone treatment, folic acid antagonists such as pyrimethamine have been noted to possibly increase the likelihood of hematologic reactions", "output": "<dapsone, effect, folic acid antagonists>, <dapsone, effect, pyrimethamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs That Should Not Be Coadministered With VIRACEPT Antiarrhythmics: amiodarone, quinidine Antihistamines: astemizole, terfenadine Antimigraine: ergot derivatives Antimycobacterial agents: rifampin Benzodiazepines midazolam, triazolam GI motility agents: cisapride", "output": "<VIRACEPT, advise, Antiarrhythmics>, <VIRACEPT, advise, amiodarone>, <VIRACEPT, advise, quinidine>, <VIRACEPT, advise, Antihistamines>, <VIRACEPT, advise, astemizole>, <VIRACEPT, advise, terfenadine>, <VIRACEPT, advise, ergot derivatives>, <VIRACEPT, advise, Antimycobacterial agents>, <VIRACEPT, advise, rifampin>, <VIRACEPT, advise, Benzodiazepines>, <VIRACEPT, advise, midazolam>, <VIRACEPT, advise, triazolam>, <VIRACEPT, advise, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs Which Require a Dose Reduction When Coadminstered With VIRACEPT Antimycobacterial agents: rifabutin", "output": "<VIRACEPT, advise, Antimycobacterial agents>, <VIRACEPT, advise, rifabutin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "therefore, VIRACEPT should not be administered concurrently with terfenadine because of the potential for serious and/or life-threatening cardiac arrhythmias.", "output": "<VIRACEPT, advise, terfenadine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because a similar interaction is likely, VIRACEPT should also not be administered concurrently with astemizole.", "output": "<VIRACEPT, advise, astemizole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Indinavir: Coadministration of indinavir with VIRACEPT resulted in an 83% increase in nelfinavir plasma AUC and a 51% increase in indinavir plasma A.C.", "output": "<indinavir, mechanism, VIRACEPT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ritonavir: Coadministration of ritonavir with VIRACEPT resulted in a 152% increase in nelfinavir plasma AUC and very little change in ritonavir plasma A.C.", "output": "<ritonavir, mechanism, VIRACEPT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Saquinavir: Coadministration of saquinavir (using an experimental soft-gelatin capsule formulation of saquinavir 1200mg) with VIRACEPT resulted in an 18% increase in nelfinavir plasma AUC and a 4-fold increase in saquinavir plasma A.C.", "output": "<saquinavir, mechanism, VIRACEPT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: Coadministration of ketoconazole with VIRACEPT resulted in a 35% increase in nelfinavir plasma A.C.", "output": "<ketoconazole, mechanism, VIRACEPT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "therefore, nelfinavir should be administered (with food) one hour after or more than two hours before didanosine.", "output": "<nelfinavir, advise, didanosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A dose adjustment is not needed when zidovudine is administered with VIRACEPT.", "output": "<zidovudine, advise, VIRACEPT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rifabutin: Coadministration of rifabutin and VIRACEPT resulted in a 32% decrease in nelfinavir plasma AUC and a 207% increase in rifabutin plasma A.C.", "output": "<rifabutin, mechanism, VIRACEPT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended that the dose of rifabutin be reduced to one-half the usual dose when administered with VIRACEPT.", "output": "<rifabutin, advise, VIRACEPT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rifampin: Coadministration of rifampin and VIRACEPT resulted in an 82% decrease in nelfinavir plasma A.C.", "output": "<rifampin, mechanism, VIRACEPT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "VIRACEPT and rifampin should not be coadministered.", "output": "<VIRACEPT, advise, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ethinyl Estradiol and Norethindrone: Coadministration of VIRACEPT with OVCON-35 resulted in a 47% decrease in ethinyl estradiol and an 18% decrease in norethindrone plasma concentrations.", "output": "<VIRACEPT, mechanism, OVCON-35>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In an in vitro study in human liver microsomes, inhibition of CYP2A6 hydroxylation of coumarin by fondaparinux (200 m m M i.e., 350 mg/L) was 17-28%.", "output": "<coumarin, mechanism, fondaparinux>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Taking a rauwolfia alkaloid while you are taking or within 2 weeks of taking MAO inhibitors may increase the risk of central nervous system depression or may cause a severe high blood pressure reaction.", "output": "<rauwolfia alkaloid, effect, MAO inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tissue culture and animal studies indicate that ELSPAR can diminish or abolish the effect of methotrexate on malignant cells.14 This effect on methotrexate activity persists as long as plasma asparagine levels are suppressed.", "output": "<ELSPAR, effect, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "These results would seem to dictate against the clinical use of methotrexate with ELSPAR, or during the period following ELSPAR therapy when plasma asparagine levels are below normal.", "output": "<methotrexate, advise, ELSPAR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Metoclopramide: When coadministered with MONUROL, metoclopramide, a drug which increases gastrointestinal motility, lowers the serum concentration and urinary excretion of fosfomycin.", "output": "<MONUROL, mechanism, metoclopramide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Etonogestrel may interact with the following medications: acetaminophen (Tylenol), antibiotics such as ampicillin and tetracycline, anticonvulsants (Dilantin, Phenobarbital, Tegretol, Trileptal, Topamax, Felbatol), antifungals (Gris-PEG, Nizoral, Sporanox), atorvastatin (Lipitor), clofibrate (Atromid-S), cyclosporine (Neoral, Sandimmune), HIV drugs classified as protease inhibitors (Agenerase, Crixivan, Fortovase, Invirase, Kaletra, Norvir, Viracept), morphine (Astramorph, Kadian, MS Contin), phenylbutazone, prednisolone (Prelone), rifadin (rifampin), St. Johns wort, temazepam, theophylline (Theo-Dur), and vitamin C.", "output": "<Etonogestrel, int, acetaminophen>, <Etonogestrel, int, Tylenol>, <Etonogestrel, int, antibiotics>, <Etonogestrel, int, ampicillin>, <Etonogestrel, int, tetracycline>, <Etonogestrel, int, anticonvulsants>, <Etonogestrel, int, Dilantin>, <Etonogestrel, int, Phenobarbital>, <Etonogestrel, int, Tegretol>, <Etonogestrel, int, Trileptal>, <Etonogestrel, int, Topamax>, <Etonogestrel, int, Felbatol>, <Etonogestrel, int, antifungals>, <Etonogestrel, int, Gris-PEG>, <Etonogestrel, int, Nizoral>, <Etonogestrel, int, Sporanox>, <Etonogestrel, int, atorvastatin>, <Etonogestrel, int, Lipitor>, <Etonogestrel, int, clofibrate>, <Etonogestrel, int, Atromid-S>, <Etonogestrel, int, cyclosporine>, <Etonogestrel, int, Neoral>, <Etonogestrel, int, Sandimmune>, <Etonogestrel, int, protease inhibitors>, <Etonogestrel, int, Agenerase>, <Etonogestrel, int, Crixivan>, <Etonogestrel, int, Fortovase>, <Etonogestrel, int, Invirase>, <Etonogestrel, int, Kaletra>, <Etonogestrel, int, Norvir>, <Etonogestrel, int, Viracept>, <Etonogestrel, int, morphine>, <Etonogestrel, int, Astramorph>, <Etonogestrel, int, Kadian>, <Etonogestrel, int, MS Contin>, <Etonogestrel, int, phenylbutazone>, <Etonogestrel, int, prednisolone>, <Etonogestrel, int, Prelone>, <Etonogestrel, int, rifadin>, <Etonogestrel, int, rifampin>, <Etonogestrel, int, temazepam>, <Etonogestrel, int, theophylline>, <Etonogestrel, int, Theo-Dur>, <Etonogestrel, int, vitamin C>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "For example, when vitamin K antagonists are administered concomitantly with nilutamide, prothrombin time should be carefully monitored and if necessary, the dosage of vitamin K antagonists should be reduced.", "output": "<vitamin K antagonists, advise, nilutamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a study in which the 2 mg clonazepam orally disintegrating tablet was administered with and without propantheline (an anticholinergic agent with multiple effects on the GI tract) to healthy volunteers, the AUC of clonazepam was 10% lower and the Cmax of clonazepam was 20% lower when the orally disintegrating tablet was given with propantheline compared to when it was given alone.", "output": "<clonazepam, mechanism, propantheline>, <clonazepam, mechanism, propantheline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital, induce clonazepam metabolism, causing an approximately 30% decrease in plasma clonazepam levels.", "output": "<phenytoin, mechanism, clonazepam>, <carbamazepine, mechanism, clonazepam>, <phenobarbital, mechanism, clonazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam.", "output": "<antifungal agents, advise, clonazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pharmacodynamic Interactions: The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.", "output": "<benzodiazepine class, effect, alcohol>, <benzodiazepine class, effect, narcotics>, <benzodiazepine class, effect, barbiturates>, <benzodiazepine class, effect, nonbarbiturate hypnotics>, <benzodiazepine class, effect, antianxiety agents>, <benzodiazepine class, effect, phenothiazines classes of antipsychotic agents>, <benzodiazepine class, effect, thioxanthene classes of antipsychotic agents>, <benzodiazepine class, effect, butyrophenone classes of antipsychotic agents>, <benzodiazepine class, effect, monoamine oxidase inhibitors>, <benzodiazepine class, effect, tricyclic antidepressants>, <benzodiazepine class, effect, anticonvulsant drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Human growth hormone - Concomitant use of L-glutamine and human growth hormone may enhance nutrient absorption in those with severe short bowel syndrome.", "output": "<L-glutamine, mechanism, human growth hormone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Indomethacin - Concomitant use of L-glutamine and indomethacin may ameliorate increased intestinal permeability caused by indomethacin.", "output": "<L-glutamine, effect, indomethacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methotrexate - There is one report that methotrexate may decrease the possible effectiveness of supplemental L-glutamine for chemotherapy-induced mucositis.", "output": "<methotrexate, effect, L-glutamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In another report, nine patients with breast cancer were reported to have decreased symptoms of methotrexate-related toxicity when given supplemental L-glutamine at a dose of 0.5 gram/kilogram/day.", "output": "<methotrexate, effect, L-glutamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Paclitaxel - In one report, L-glutamine at a dose of 10 grams three times daily, given 24 hours after receiving paclitaxel, appeared to prevent the development of myalgia and arthralgia, adverse reactions of paclitaxel.", "output": "<L-glutamine, effect, paclitaxel>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Fenfluramine may increase slightly the effect of antihypertensive drugs, e.g., guanethidine, methyldopa, reserpine.", "output": "<Fenfluramine, effect, antihypertensive drugs>, <Fenfluramine, effect, guanethidine>, <Fenfluramine, effect, methyldopa>, <Fenfluramine, effect, reserpine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other CNS depressant drugs should be used with caution in patients taking fenfluramine, since the effects may be additive.", "output": "<CNS depressant drugs, advise, fenfluramine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, co  administration of fexofenadine hydrochloride with either ketoconazole or erythromycin led to increased plasma concentrations of fexofenadine.", "output": "<fexofenadine hydrochloride, mechanism, ketoconazole>, <fexofenadine hydrochloride, mechanism, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "These studies indicate that ketoconazole or erythromycin co-administration enhances fexofenadine gastrointestinal absorption.", "output": "<ketoconazole, mechanism, fexofenadine>, <erythromycin, mechanism, fexofenadine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This observed increase in the bioavailability of fexofenadine may be due to transport-related effects, such as p-glycoprotein. in vivo animal studies also suggest that in addition to enhancing absorption, ketoconazole decreases fexofenadine gastrointestinal secretion, while erythromycin may also decrease biliary excretion.", "output": "<ketoconazole, mechanism, fexofenadine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drug Interactions with Antacids Administration of 120 mg of fexofenadine hydrochloride (2 x 60 mg capsule) within 15 minutes of an aluminum and magnesium containing antacid (Maalox ) decreased fexofenadine AUC by 41% and cmax by 43%.", "output": "<fexofenadine hydrochloride, mechanism, aluminum>, <fexofenadine hydrochloride, mechanism, magnesium>, <fexofenadine hydrochloride, mechanism, antacid>, <fexofenadine hydrochloride, mechanism, Maalox>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ALLEGRA should not be taken closely in time with aluminum and magnesium containing antacids.", "output": "<ALLEGRA, advise, aluminum>, <ALLEGRA, advise, magnesium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients receiving other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, tricyclic antidepressants or other CNS depressants (including alcohol) concomitantly with DILAUDID may exhibit an additive CNS depression.", "output": "<narcotic analgesic, effect, DILAUDID>, <anesthetics, effect, DILAUDID>, <phenothiazines, effect, DILAUDID>, <tranquilizers, effect, DILAUDID>, <sedative-hypnotics, effect, DILAUDID>, <tricyclic antidepressants, effect, DILAUDID>, <CNS depressants, effect, DILAUDID>, <alcohol, effect, DILAUDID>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacid: When atorvastatin and Maalox TC suspension were coadministered, plasma concentrations of atorvastatin decreased approximately 35%.", "output": "<atorvastatin, mechanism, Maalox TC>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Colestipol: Plasma concentrations of atorvastatin decreased approximately 25% when colestipol and atorvastatin were coadministered.", "output": "<colestipol, mechanism, atorvastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, LDL-C reduction was greater when atorvastatin and colestipol were coadministered than when either drug was given alone.", "output": "<atorvastatin, effect, colestipol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digoxin: When multiple doses of atorvastatin and digoxin were coadministered, steady-state plasma digoxin concentrations increased by approximately 20%.", "output": "<atorvastatin, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Erythromycin: In healthy individuals, plasma concentrations of atorvastatin increased approximately 40% with coadministration of atorvastatin and erythromycin, a known inhibitor of cytochrome P450 3A4.", "output": "<atorvastatin, mechanism, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oral Contraceptives: Coadministration of atorvastatin and an oral contraceptive increased AUC values for norethindrone and ethinyl estradiol by approximately 30% and 20%.", "output": "<atorvastatin, mechanism, contraceptive>, <atorvastatin, mechanism, norethindrone>, <atorvastatin, mechanism, ethinyl estradiol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "These increases should be considered when selecting an oral contraceptive for a woman taking atorvastatin.", "output": "<contraceptive, advise, atorvastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be exercised if an HMG-CoA reductase inhibitor is administered concomitantly with drugs that may decrease the levels or activity of endogenous steroid hormones, such as ketoconazole, spironolactone, and cimetidine.", "output": "<HMG-CoA reductase inhibitor, advise, ketoconazole>, <HMG-CoA reductase inhibitor, advise, spironolactone>, <HMG-CoA reductase inhibitor, advise, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Before taking glimepiride, tell your doctor if you are taking any of the following medicines: - aspirin or another salicylate such as magnesium/choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan), or bismuth subsalicylate (Pepto-Bismol);", "output": "<glimepiride, advise, aspirin>, <glimepiride, advise, salicylate>, <glimepiride, advise, magnesium/choline salicylate>, <glimepiride, advise, Trilisate>, <glimepiride, advise, salsalate>, <glimepiride, advise, Disalcid>, <glimepiride, advise, choline salicylate>, <glimepiride, advise, Arthropan>, <glimepiride, advise, magnesium salicylate>, <glimepiride, advise, Magan>, <glimepiride, advise, bismuth subsalicylate>, <glimepiride, advise, Pepto-Bismol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "HEMABATE may augment the activity of other oxytocic agents.", "output": "<HEMABATE, effect, oxytocic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function.", "output": "<Furosemide, effect, aminoglycoside antibiotics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity.", "output": "<Furosemide, advise, ethacrynic acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients receiving high doses of salicylates concomitantly with furosemide, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.", "output": "<salicylates, effect, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine.", "output": "<Furosemide, effect, tubocurarine>, <Furosemide, effect, succinylcholine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium generally should not be given with diuretics because they reduce lithiums renal clearance and add a high risk of lithium toxicity.", "output": "<Lithium, advise, diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide may add to or potentiate the therapeutic effect of other antihypertensive drugs.", "output": "<Furosemide, effect, antihypertensive drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide may decrease arterial responsiveness to norepinephrine.", "output": "<Furosemide, effect, norepinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tablets Simultaneous administration of sucralfate and furosemide tablets may reduce the natriuretic and antihypertensive effects of furosemide.", "output": "<sucralfate, effect, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The intake of furosemide and sucralfate should be separated by at least two hours.", "output": "<furosemide, advise, sucralfate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tablets, Injection, and Oral Solution One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency.", "output": "<furosemide, effect, acetylsalicylic acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs.", "output": "<furosemide, effect, NSAIDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis.", "output": "<indomethacin, effect, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients receiving both indomethacin and furosemide should be observed closely to determine if the desired diuretic and/or antihypertensive effect of furosemide is achieved.", "output": "<indomethacin, advise, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin: Meclofenamate sodium enhances the effect of warfarin.", "output": "<Warfarin, effect, Meclofenamate sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, when meclofenamate sodium is given to a patient receiving warfarin, the dosage of warfarin should be reduced to prevent excessive prolongation of the prothrombin time.", "output": "<meclofenamate sodium, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: Concurrent administration of aspirin may lower meclofenamate sodium plasma levels, possibly by competing for protein-binding sites.", "output": "<aspirin, mechanism, meclofenamate sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.", "output": "<oxyphenbutazone, mechanism, androgens>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements.", "output": "<androgens, effect, insulin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Bacteriostatic Antibiotics: Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins.", "output": "<Chloramphenicol, effect, penicillins>, <erythromycins, effect, penicillins>, <sulfonamides, effect, penicillins>, <tetracyclines, effect, penicillins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid: May decrease renal tubular secretion of ampicillin resulting in increased blood levels and/or ampicillin toxicity.", "output": "<Probenecid, mechanism, ampicillin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digoxin: In controlled studies in healthy volunteers, bepridil hydrochloride either had no effect (one study) or was associated with modest increases, about 30% (two studies) in steady-state serum digoxin concentrations.", "output": "<bepridil hydrochloride, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anti-arrhythmics and tricyclic anti-depressants could exaggerate the prolongation of the QT interval observed with bepridil hydrochloride.", "output": "<Anti-arrhythmics, effect, bepridil hydrochloride>, <tricyclic anti-depressants, effect, bepridil hydrochloride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cardiac glycosides could exaggerate the depression of AV nodal conduction observed with bepridil hydrochloride.", "output": "<Cardiac glycosides, effect, bepridil hydrochloride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.", "output": "<Tetracycline, effect, penicillin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta-blockers, clonidine, lithium salts, and alcohol may either potentiate or weaken the blood-glucose-lowering effect of insulin.", "output": "<Beta-blockers, effect, insulin>, <clonidine, effect, insulin>, <lithium, effect, insulin>, <alcohol, effect, insulin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dopamine D2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone) and isoniazid may reduce the therapeutic effects of levodopa.", "output": "<Dopamine D2 receptor antagonists, effect, levodopa>, <phenothiazines, effect, levodopa>, <butyrophenones, effect, levodopa>, <risperidone, effect, levodopa>, <isoniazid, effect, levodopa>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition, the beneficial effects of levodopa in Parkinsons disease have been reported to be reversed by phenytoin and papaverine.", "output": "<levodopa, effect, phenytoin>, <levodopa, effect, papaverine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Iron salts may reduce the bioavailability of carbidopa and levodopa.", "output": "<Iron, mechanism, carbidopa>, <Iron, mechanism, levodopa>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although metoclopramide may increase the bioavailability of levodopa by increasing gastric emptying, metoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.", "output": "<metoclopramide, mechanism, levodopa>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since hydroxyurea may raise the serum uric acid level, dosage adjustment of uricosuric medication may be necessary", "output": "<hydroxyurea, effect, uricosuric medication>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent use with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir.", "output": "<probenecid, mechanism, penciclovir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics.", "output": "<aminoglycoside antibiotics, effect, cephalosporin antibiotics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of probenecid doubled the AUC for cefprozil.", "output": "<probenecid, mechanism, cefprozil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Both the magnitude and duration of central nervous system and cardiovascular effects may be enhanced when ALFENTA is administered in combination with other CNS depressants such as barbiturates, tranquilizers, opioids, or inhalation general anesthetics.", "output": "<ALFENTA, effect, CNS depressants>, <ALFENTA, effect, barbiturates>, <ALFENTA, effect, tranquilizers>, <ALFENTA, effect, opioids>, <ALFENTA, effect, anesthetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Limited clinical experience indicates that requirements for volatile inhalation anesthetics are reduced by 30 to 50% for the first sixty (60) minutes following ALFENTA induction The concomitant use of erythromycin with ALFENTA can significantly inhibit ALFENTA clearance and may increase the risk of prolonged or delayed respiratory depression.", "output": "<volatile inhalation anesthetics, mechanism, ALFENTA>, <erythromycin, mechanism, ALFENTA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine reduces the clearance of ALFENTA.", "output": "<Cimetidine, mechanism, ALFENTA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diphenoxylate HCl and atropine sulfate may interact with MAO inhibitors In studies with male rats, diphenoxylate hydrochloride was found to inhibit the hepatic microsomal enzyme system at a dose of 2 mg/kg/day.", "output": "<Diphenoxylate HCl, int, MAO inhibitors>, <atropine sulfate, int, MAO inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although deferasirox has a lower affinity for aluminum than for iron, Exjade should not be taken with aluminum-containing antacid preparations.", "output": "<Exjade, advise, aluminum>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The use of codeine may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.", "output": "<codeine, effect, alcohol>, <codeine, effect, antihistamines>, <codeine, effect, psychotropics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Serious toxicity may result if dextromethorphan is coadministered with monoamine oxidase inhibitors (MAOIs).", "output": "<dextromethorphan, effect, monoamine oxidase inhibitors>, <dextromethorphan, effect, MAOIs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The use of dextromethorphan hydrobromide may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.", "output": "<dextromethorphan hydrobromide, effect, alcohol>, <dextromethorphan hydrobromide, effect, antihistamines>, <dextromethorphan hydrobromide, effect, psychotropics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cholestyramine resin may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic) or propranolol (basic), as well as tetracycline penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis.", "output": "<Cholestyramine, mechanism, phenylbutazone>, <Cholestyramine, mechanism, warfarin>, <Cholestyramine, mechanism, thiazide diuretics>, <Cholestyramine, mechanism, propranolol>, <Cholestyramine, mechanism, tetracycline>, <Cholestyramine, mechanism, penicillin G>, <Cholestyramine, mechanism, phenobarbital>, <Cholestyramine, mechanism, thyroxine>, <Cholestyramine, mechanism, estrogens>, <Cholestyramine, mechanism, progestins>, <Cholestyramine, mechanism, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cholestyramine resin may interfere with the pharmacokinetics of drugs that undergo enterohepatic circulation, The discontinuance of cholestyramine resin could pose a hazard to health if a potentially toxic drug such as digitalis has been filtrated to a maintenance level while the patient was taking cholestyramine resin.", "output": "<cholestyramine, mechanism, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Agents that are CYP3A4 inhibitors that have been found, or are expected, to increase plasma levels of EQUETROTM are the following: Acetazolamide, azole antifungals, cimetidine, clarithromycin(1), dalfopristin, danazol, delavirdine, diltiazem, erythromycin(1), fluoxetine, fluvoxamine, grapefruit juice, isoniazid, itraconazole, ketoconazole, loratadine, nefazodone, niacinamide, nicotinamide, protease inhibitors, propoxyphene, quinine, quinupristin, troleandomycin, valproate(1), verapamil, zileuton.", "output": "<EQUETROTM, mechanism, Acetazolamide>, <EQUETROTM, mechanism, azole antifungals>, <EQUETROTM, mechanism, cimetidine>, <EQUETROTM, mechanism, clarithromycin>, <EQUETROTM, mechanism, dalfopristin>, <EQUETROTM, mechanism, danazol>, <EQUETROTM, mechanism, delavirdine>, <EQUETROTM, mechanism, diltiazem>, <EQUETROTM, mechanism, erythromycin>, <EQUETROTM, mechanism, fluoxetine>, <EQUETROTM, mechanism, fluvoxamine>, <EQUETROTM, mechanism, isoniazid>, <EQUETROTM, mechanism, itraconazole>, <EQUETROTM, mechanism, ketoconazole>, <EQUETROTM, mechanism, loratadine>, <EQUETROTM, mechanism, nefazodone>, <EQUETROTM, mechanism, niacinamide>, <EQUETROTM, mechanism, nicotinamide>, <EQUETROTM, mechanism, protease inhibitors>, <EQUETROTM, mechanism, propoxyphene>, <EQUETROTM, mechanism, quinine>, <EQUETROTM, mechanism, quinupristin>, <EQUETROTM, mechanism, troleandomycin>, <EQUETROTM, mechanism, valproate>, <EQUETROTM, mechanism, verapamil>, <EQUETROTM, mechanism, zileuton>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Agents that are CYP inducers that have been found, or are expected, to decrease plasma levels of EQUETROTM are the following: Cisplatin, doxorubicin HCL, felbamate, rifampin, phenobarbital, Phenytoin(2), primidone, methsuximide, and theophylline Thus, if a patient has been titrated to a stable dosage on EQUETROTM, and then begins a course of treatment with one of these CYP3A4 inducers, it is reasonable to expect that a dose increase for EQUETROTM may be necessary.", "output": "<EQUETROTM, mechanism, Cisplatin>, <EQUETROTM, mechanism, doxorubicin HCL>, <EQUETROTM, mechanism, felbamate>, <EQUETROTM, mechanism, rifampin>, <EQUETROTM, mechanism, phenobarbital>, <EQUETROTM, mechanism, Phenytoin>, <EQUETROTM, mechanism, primidone>, <EQUETROTM, mechanism, methsuximide>, <EQUETROTM, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Agents that have been found, or are expected to have decreased plasma levels in the presence of EQUETROTM due to induction of CYP enzymes are the following: Acetaminophen, alprazolam, amitriptyline, bupropion, buspirone, citalopram, clobazam, clonazepam, clozapine, cyclosporin, delavirdine, desipramine, diazepam, dicumarol, doxycycline, ethosuximide, felbamate, felodipine, glucocorticoids, haloperidol, itraconazole, lamotrigine, levothyroxine, lorazepam, methadone, midazolam, mirtazapine, nortriptyline, olanzapine, oral contraceptives(3), oxcarbazepine, Phenytoin(4), praziquantel, protease inhibitors, quetiapine, risperidone, theophylline, topiramate, tiagabine, tramadol, triazolam, valproate, warfarin(5) , ziprasidone, and zonisamide.", "output": "<EQUETROTM, mechanism, Acetaminophen>, <EQUETROTM, mechanism, alprazolam>, <EQUETROTM, mechanism, amitriptyline>, <EQUETROTM, mechanism, bupropion>, <EQUETROTM, mechanism, buspirone>, <EQUETROTM, mechanism, citalopram>, <EQUETROTM, mechanism, clobazam>, <EQUETROTM, mechanism, clonazepam>, <EQUETROTM, mechanism, clozapine>, <EQUETROTM, mechanism, cyclosporin>, <EQUETROTM, mechanism, delavirdine>, <EQUETROTM, mechanism, desipramine>, <EQUETROTM, mechanism, diazepam>, <EQUETROTM, mechanism, dicumarol>, <EQUETROTM, mechanism, doxycycline>, <EQUETROTM, mechanism, ethosuximide>, <EQUETROTM, mechanism, felbamate>, <EQUETROTM, mechanism, felodipine>, <EQUETROTM, mechanism, glucocorticoids>, <EQUETROTM, mechanism, haloperidol>, <EQUETROTM, mechanism, itraconazole>, <EQUETROTM, mechanism, lamotrigine>, <EQUETROTM, mechanism, levothyroxine>, <EQUETROTM, mechanism, lorazepam>, <EQUETROTM, mechanism, methadone>, <EQUETROTM, mechanism, midazolam>, <EQUETROTM, mechanism, mirtazapine>, <EQUETROTM, mechanism, nortriptyline>, <EQUETROTM, mechanism, olanzapine>, <EQUETROTM, mechanism, contraceptives>, <EQUETROTM, mechanism, oxcarbazepine>, <EQUETROTM, mechanism, Phenytoin>, <EQUETROTM, mechanism, praziquantel>, <EQUETROTM, mechanism, protease inhibitors>, <EQUETROTM, mechanism, quetiapine>, <EQUETROTM, mechanism, risperidone>, <EQUETROTM, mechanism, theophylline>, <EQUETROTM, mechanism, topiramate>, <EQUETROTM, mechanism, tiagabine>, <EQUETROTM, mechanism, tramadol>, <EQUETROTM, mechanism, triazolam>, <EQUETROTM, mechanism, valproate>, <EQUETROTM, mechanism, warfarin>, <EQUETROTM, mechanism, ziprasidone>, <EQUETROTM, mechanism, zonisamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Agents with Increased Levels in the Presence of Carbamazepine: EQUETROTM increases the plasma levels of the following agents: Clomipramine HCl, Phenytoin(6), and primidone Thus, if a patient has been titrated to a stable dosage on one of the agents in this category, and then begins a course of the treatment with EQUETROTM, it is reasonable to expect that a dose decrease for the concomitant agent may be necessary.", "output": "<EQUETROTM, mechanism, Clomipramine HCl>, <EQUETROTM, mechanism, Phenytoin>, <EQUETROTM, mechanism, primidone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pharmacological/Pharmacodynamic Interactions with Carbamazepine Concomitant administration of carbamazepine and lithium may increase the risk of neurotoxic side effects.", "output": "<carbamazepine, effect, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Additionally, anti-malarial drugs, such as chloroquine and mefloquine, may antagonize the activity of carbamazepine.", "output": "<anti-malarial drugs, effect, carbamazepine>, <chloroquine, effect, carbamazepine>, <mefloquine, effect, carbamazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because of its primary CNS effect, caution should be used when EQUETROTM is taken with other centrally acting drugs and alcohol.", "output": "<EQUETROTM, advise, centrally acting drugs>, <EQUETROTM, advise, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients receiving another serotonin reuptake inhibitor drug in combination with monoamine oxidase inhibitors (MAOI), there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma.", "output": "<serotonin reuptake inhibitor drug, effect, monoamine oxidase inhibitors>, <serotonin reuptake inhibitor drug, effect, MAOI>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, it is recommended that Fluvoxamine Tablets not be used in combination with MAOIs, or within 14 days of discontinuing treatment with a MAOI.", "output": "<Fluvoxamine, advise, MAOIs>, <Fluvoxamine, advise, MAOI>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "After stopping Fluvoxamine Tablets, at least 2 weeks should be allowed before starting a MAOI.", "output": "<Fluvoxamine, advise, MAOI>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Terfenadine, astemizole and cisapride are all metabolized by the cytochrome P450IIIA4 isozyme, and it has been demonstrated that ketoconazole, a potent inhibitor of IIIA4, blocks the metabolism of these drugs, resulting in increased plasma concentrations of parent drug.", "output": "<Terfenadine, mechanism, ketoconazole>, <astemizole, mechanism, ketoconazole>, <cisapride, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although it has not been definitively demonstrated that fluvoxamine is a potent IIIA4 inhibitor, it is likely to be, given the substantial interaction of fluvoxamine with alprazolam.", "output": "<fluvoxamine, int, alprazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Consequently, it is recommended that fluvoxamine not be used in combination with either terbinafine, astemizole, or cisapride.", "output": "<fluvoxamine, advise, terbinafine>, <fluvoxamine, advise, astemizole>, <fluvoxamine, advise, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other Potentially Important Drug Interactions: Benzodiazepines: Benzodiazepines metabolized by hepatic oxidation (e.g., alprazolam, midazolam, triazolam elc.) should be used with caution because the clearance of these drugs is likely to be reduced by fluvoxamine.", "output": "<Benzodiazepines, mechanism, fluvoxamine>, <alprazolam, mechanism, fluvoxamine>, <midazolam, mechanism, fluvoxamine>, <triazolam, mechanism, fluvoxamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Alprazolam: When fluvoxamine maleate (100 mg qd) and alprazolam (1 mg q.d. were co-administered to steady state, plasma concentration and other pharmacokinetics parameters (AUC, Cmax, T1/2,) of alprazolam were approximately twice those observed when alprazolam was administered alone;", "output": "<fluvoxamine maleate, mechanism, alprazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This interaction, which has not been investigated using higher doses of fluvoxamine, may be more pronounced if a 300 mg daily dose is co-administered, particularly since fluvoxamine exhibits non-linear pharmacokinetics over the dosage range 100-300 mg. If alprazolam is co-administered with Fluvoxamine Tablets, the initial alprazolam dosage should be at least halved and titration to the lowest effective dose is recommended.", "output": "<alprazolam, advise, Fluvoxamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diazepam: The co-administration of Fluvoxamine Tablets and diazepam is generally not advisable.", "output": "<Fluvoxamine, advise, diazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because fluvoxamine reduces the clearance of both diazepam and its active metabolite, N-desmethyldiazepam, there is a strong likelihood of substantial accumulation of both species during chronic co-administration.", "output": "<fluvoxamine, mechanism, diazepam>, <fluvoxamine, mechanism, N-desmethyldiazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Evidence supporting the conclusion that it is inadvisable to co-administer fluvoxamine and diazepam is derived from a study in which healthy volunteers taking 150 mg/day of fluvoxamine were administered a single oral dose of 10 mg of diazepam.", "output": "<fluvoxamine, advise, diazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Moreover, as noted with alprazolam, the effect of fluvoxamine may even be more pronounced when it is administered at higher doses.", "output": "<alprazolam, effect, fluvoxamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Accordingly, diazepam and fluvoxamine should not ordinarily be co-administered.", "output": "<diazepam, advise, fluvoxamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, if theophylline is co-administered with fluvoxamine maleate, its dose should be reduced to one third of the usual daily maintenance dose and plasma concentrations of theophylline should to monitored.", "output": "<theophylline, advise, fluvoxamine maleate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin: When fluvoxamine maleate (50 mg tid) was administered concomitantly with warfarin for two weeks, warfarin plasma concentrations increased by 98% and prothrombin times were prolonged.", "output": "<fluvoxamine maleate, mechanism, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus patients receiving oral anticoagulants and Fluvoxamine Tablets should have their prothrombin time monitored and their anticoagulant dose adjusted accordingly.", "output": "<anticoagulants, advise, Fluvoxamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, caution should be used when administering nitazoxanide concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur (e.g., warfarin).", "output": "<nitazoxanide, mechanism, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The most commonly occurring drug interactions are listed below: - Drugs that may increase plasma phenytoin concentrations include: acute alcohol intake, amiodarone, chboramphenicol, chlordiazepoxide, cimetidine, diazepam, dicumarol, disulfiram, estrogens, ethosuximide, fluoxetine, H2-antagonists, halothane, isoniazid, methylphenidate, phenothiazines, phenylbutazone, salicylates, succinimides, sulfonamides, tolbutamide, trazodone", "output": "<phenytoin, mechanism, alcohol>, <phenytoin, mechanism, amiodarone>, <phenytoin, mechanism, chlordiazepoxide>, <phenytoin, mechanism, cimetidine>, <phenytoin, mechanism, diazepam>, <phenytoin, mechanism, dicumarol>, <phenytoin, mechanism, disulfiram>, <phenytoin, mechanism, estrogens>, <phenytoin, mechanism, ethosuximide>, <phenytoin, mechanism, fluoxetine>, <phenytoin, mechanism, H2-antagonists>, <phenytoin, mechanism, halothane>, <phenytoin, mechanism, isoniazid>, <phenytoin, mechanism, methylphenidate>, <phenytoin, mechanism, phenothiazines>, <phenytoin, mechanism, phenylbutazone>, <phenytoin, mechanism, salicylates>, <phenytoin, mechanism, succinimides>, <phenytoin, mechanism, sulfonamides>, <phenytoin, mechanism, tolbutamide>, <phenytoin, mechanism, trazodone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Drugs that may decrease plasma phenytoin concentrations include: carbamazepine, chronic alcohol abuse, reserpine", "output": "<phenytoin, mechanism, carbamazepine>, <phenytoin, mechanism, alcohol>, <phenytoin, mechanism, reserpine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Drugs that may either increase or decrease plasma phenytoin concentrations include: phenobarbital, vaiproic acid, and sodium valproate.", "output": "<phenytoin, mechanism, phenobarbital>, <phenytoin, mechanism, sodium valproate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Similarly, the effects of phenytoin on phenobarbital, valproic acid and sodium plasma valproate concentrations are unpredictable", "output": "<phenytoin, effect, phenobarbital>, <phenytoin, effect, valproic acid>, <phenytoin, effect, valproate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Although not a true drug interaction, tricyclic antidepressants may precipitate seizures in susceptible patients and Cerebyx dosage may need to be adjusted", "output": "<tricyclic antidepressants, effect, Cerebyx>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Drugs whose efficacy is impaired by phenytoin include: anticoagulants, corticosteroids, coumarin, digitoxin, doxycycline, estrogens, furosemide, oral contraceptives, rifampin, quinidine, theophylline, vitamin D.", "output": "<phenytoin, effect, anticoagulants>, <phenytoin, effect, corticosteroids>, <phenytoin, effect, coumarin>, <phenytoin, effect, digitoxin>, <phenytoin, effect, doxycycline>, <phenytoin, effect, estrogens>, <phenytoin, effect, furosemide>, <phenytoin, effect, contraceptives>, <phenytoin, effect, rifampin>, <phenytoin, effect, quinidine>, <phenytoin, effect, theophylline>, <phenytoin, effect, vitamin D>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Catecholamine-depleting drugs (eg, reserpine) may have an additive effect when given with beta-blocking agents.", "output": "<reserpine, effect, beta-blocking agent>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Calcium channel blockers may also have an additive effect when given with TENORMIN .", "output": "<Calcium channel blockers, effect, TENORMIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.", "output": "<Beta blockers, effect, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If the two drugs are coadministered, the beta blocker should be withdrawn several days before the gradual withdrawal of clonidine.", "output": "<beta blocker, advise, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If replacing clonidine by beta-blocker therapy, the introduction of beta blockers should be delayed for several days after clonidine administration has stopped.", "output": "<beta blockers, advise, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of prostaglandin synthase inhibiting drugs, eg, indomethacin, may decrease the hypotensive effects of beta blockers.", "output": "<indomethacin, effect, beta blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Interactions may occur between EPA supplements and aspirin and other non-steroidal anti-inflammatory drugs and herbs such as garlic (Allium sativum) and ginkgo (Ginkgo biloba).", "output": "<EPA, int, aspirin>, <EPA, int, non-steroidal anti-inflammatory drugs>, <EPA, int, ginkgo>, <EPA, int, Ginkgo biloba>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When administered concurrently, the following drugs may interact with amphotericin B: Antineoplastic agents: may enhance the potential for renal toxicity, bronchospasm and hypotension.", "output": "<amphotericin B, effect, Antineoplastic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticosteroids and Corticotropin (ACTH): may potentiate amphotericin B- induced hypokalemia which may predispose the patient to cardiac dysfunction.", "output": "<Corticosteroids, effect, amphotericin B>, <Corticotropin, effect, amphotericin B>, <ACTH, effect, amphotericin B>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digitalis glycosides: amphotericin B-induced hypokalemia may potentiate digitalis toxicity.", "output": "<amphotericin B, effect, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Flucytosine: while a synergistic relationship with amphotericin B has been reported, concomitant use may increase the toxicity of flucytosine by possibly increasing its cellular uptake and/or impairing its renal excretion.", "output": "<amphotericin B, effect, flucytosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Imidazoles (e. g., ketoconazole, miconazole, clotrimazole, fluconazole, etc.): in vitro and animal studies with the combination of amphotericin B and imidazoles suggest that imidazoles may induce fungal resistance to amphotericin B.", "output": "<imidazoles, effect, amphotericin B>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Skeletal muscle relaxants: amphotericin B-induced hypokalemia may enhance the curariform effect of skeletal muscle relaxants (e.g., tubocurarine).", "output": "<amphotericin B, effect, skeletal muscle relaxants>, <amphotericin B, effect, tubocurarine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Leukocyte transfusions: acute pulmonary toxicity has been reported in patients receiving intravenous amphotericin B and leukocyte transfusions.", "output": "<amphotericin B, effect, leukocyte transfusions>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The absorption of lymecycline may be affected by the simultaneous administration of indigestion remedies, iron or zinc supplements.", "output": "<lymecycline, mechanism, iron>, <lymecycline, mechanism, zinc>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oral contraceptives may be less effective while you are taking lymecycline.", "output": "<contraceptives, effect, lymecycline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Additional reductions in blood pressure may occur when FLOLAN is administered with diuretics, antihypertensive agents, or other vasodilators.", "output": "<FLOLAN, effect, diuretics>, <FLOLAN, effect, antihypertensive agents>, <FLOLAN, effect, vasodilators>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When other antiplatelet agents or anticoagulants are used concomitantly, there is the potential for FLOLAN to increase the risk of bleeding.", "output": "<antiplatelet agents, effect, FLOLAN>, <anticoagulants, effect, FLOLAN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In clinical trials, FLOLAN was used with digoxin, diuretics, anticoagulants, oral vasodilators, and supplemental oxygen.In a pharmacokinetic substudy in patients with congestive heart failure receiving furosemide or digoxin in whom therapy with FLOLAN was initiated, apparent oral clearance values for furosemide (n = 23) and digoxin (n = 30) were decreased by 13% and 15%, respectively, on the second day of therapy and had returned to baseline values by day 87.", "output": "<furosemide, mechanism, FLOLAN>, <digoxin, mechanism, FLOLAN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, patients on digoxin may show elevations of digoxin concentrations after initiation of therapy with FLOLAN, which may be clinically significant in patients prone to digoxin toxicity.", "output": "<digoxin, mechanism, FLOLAN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporine - L-arginine may counteract the antinaturetic effect of cyclosporin.", "output": "<L-arginine, effect, cyclosporin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ibuprofen - L-arginine may increase the absorption of ibuprofen if taken concomitantly.", "output": "<L-arginine, mechanism, ibuprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Organic nitrates - L-arginine supplements theoretically may potentiate the effects of organic nitrates if taken concomitantly.", "output": "<L-arginine, effect, nitrates>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sildenafil citrate - Theoretically, L-arginine supplements taken concomitantly with sildenafil citrate, may potentiate the effects of the drug.", "output": "<L-arginine, effect, sildenafil citrate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and AXERT within 24 hours of each other should be avoided.", "output": "<ergotamine, advise, AXERT>, <ergot-type medications, advise, AXERT>, <dihydroergotamine, advise, AXERT>, <methysergide, advise, AXERT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Monoamine Oxidase Inhibitors: Coadministration of moclobemide resulted in a 27% decrease in almotriptan clearance and an increase in Cmax of approximately 6%.", "output": "<moclobemide, mechanism, almotriptan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other 5-HT1B/1D Agonists Concomitant use of other 5-HT1B/1D agonists within 24 hours of treatment with AXERT is contraindicated.", "output": "<5-HT1B/1D agonists, advise, AXERT>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Selective Serotonin Reuptake Inhibitors (SSRIs): SSRIs (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline) have been rarely reported to cause weakness, hyperreflexia, and incoordination when coadministered with 5-HT1 agonists.", "output": "<SSRIs, effect, 5-HT1 agonists>, <fluoxetine, effect, 5-HT1 agonists>, <fluvoxamine, effect, 5-HT1 agonists>, <paroxetine, effect, 5-HT1 agonists>, <sertraline, effect, 5-HT1 agonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If concomitant treatment with AXERT and an SSRI is clinically warranted, appropriate observation of the patient is advised.", "output": "<AXERT, advise, SSRI>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Verapamil: Coadministration of almotriptan and verapamil resulted in a 24% increase in plasma concentrations of almotriptan.", "output": "<almotriptan, mechanism, verapamil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of almotriptan and the potent CYP3A4 inhibitor ketoconazole (400 mg q.d. for 3 days) resulted in an approximately 60% increase in the area under the plasma concentration-time curve and maximal plasma concentrations of almotriptan.", "output": "<almotriptan, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although the interaction between almotriptan and other potent CYP3A4 inhibitors (e.g., itraconazole, ritonavir, and erythromycin) has not been studied, increased exposures to almotriptan may be expected when almotriptan is used concomitantly with these medications.", "output": "<itraconazole, advise, almotriptan>, <ritonavir, advise, almotriptan>, <erythromycin, advise, almotriptan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lamivudine and zalcitabine may inhibit the intracellular phosphorylation of one another.", "output": "<Lamivudine, effect, zalcitabine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, use of lamivudine in combination with zalcitabine is not recommended", "output": "<lamivudine, advise, zalcitabine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Folic acid in large amounts may counteract the antiepileptic effect of phenobarbital, phenytoin and primidone, and increase the frequency of seizures in susceptible pediatric patients.", "output": "<Folic acid, effect, phenobarbital>, <Folic acid, effect, phenytoin>, <Folic acid, effect, primidone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, high doses of leucovorin may reduce the efficacy of intrathecally administered methotrexate.", "output": "<leucovorin, effect, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Leucovorin may enhance the toxicity of 5-fluorouracil.", "output": "<Leucovorin, effect, 5-fluorouracil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The following drug interactions have been identified involving NIZORAL Tablets and other drugs metabolized by the cytochrome P450 3A4 enzyme system: Ketoconazole tablets inhibit the metabolism of terfenadine, resulting in an increased plasma concentration of terfenadine and a delay in the elimination of its acid metabolite.", "output": "<Ketoconazole, mechanism, terfenadine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pharmacokinetic data indicate that oral ketoconazole inhibits the metabolism of astemizole, resulting in elevated plasma levels of astemizole and its active metabolite desmethylastemizole which may prolong QT intervals.", "output": "<ketoconazole, effect, astemizole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of astemizole with ketoconazole tablets is therefore contraindicated.", "output": "<astemizole, advise, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Human pharmacokinetics data indicate that oral ketoconazole potently inhibits the metabolism of cisapride resulting in a mean eight-fold increase in AUC of cisapride.", "output": "<ketoconazole, mechanism, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Data suggest that coadministration of oral ketoconazole and cisapride can result in prolongation of the QT interval on the ECG.", "output": "<ketoconazole, effect, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore concomitant administration of ketoconazole tablets with cisapride is contraindicated.", "output": "<ketoconazole, advise, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole tablets may alter the metabolism of cyclosporine, tacrolimus, and methylprednisolone, resulting in elevated plasma concentrations of the latter drugs.", "output": "<Ketoconazole, mechanism, cyclosporine>, <Ketoconazole, mechanism, tacrolimus>, <Ketoconazole, mechanism, methylprednisolone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of NIZORAL  Tablets with midazolam or triazolam has resulted in elevated plasma concentrations of the latter two drugs.", "output": "<NIZORAL, mechanism, midazolam>, <NIZORAL, mechanism, triazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is, therefore, advisable to monitor digoxin concentrations in patients receiving ketoconazole.", "output": "<digoxin, advise, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When taken orally , imidazole compounds like ketoconazole may enhance the anticoagulant effect of coumarin-like drugs.", "output": "<imidazole compounds, effect, coumarin>, <ketoconazole, effect, coumarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In simultaneous treatment with imidazole drugs and coumarin drugs, the anticoagulant effect should be carefully titrated and monitored.", "output": "<imidazole drugs, advise, coumarin drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because severe hypoglycemia has been reported in patients concomitantly receiving oral miconazole (an imidazole) and oral hypoglycemic agents, such a potential interaction involving the latter agents when used concomitantly with ketoconazole tablets (an imidazole) can not be ruled out.", "output": "<miconazole, effect, hypoglycemic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of ketoconazole tablets with phenytoin may alter the metabolism of one or both of the drugs.", "output": "<ketoconazole, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is suggested to monitor both ketoconazole and phenytoin.", "output": "<ketoconazole, advise, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of rifampin with ketoconazole tablets reduces the blood levels of the latter.", "output": "<rifampin, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "INH (Isoniazid) is also reported to affect ketoconazole concentrations adversely.", "output": "<INH, mechanism, ketoconazole>, <Isoniazid, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "After the coadministration of 200 mg oral ketoconazole twice daily and one 20 mg dose of loratadine to 11 subjects, the AUC and Cmax of loratadine averaged 302% (  142 S.D.) and 251% (  68 S.D.), respectively, of those obtained after co-treatment with placebo.", "output": "<ketoconazole, mechanism, loratadine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although the occurrence has not been reported with Cefizox, nephrotoxicity has been reported following concomitant administration of other cephalosporins and aminoglycosides.", "output": "<cephalosporins, effect, aminoglycosides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response.", "output": "<phenobarbital, mechanism, corticosteroids>, <phenobarbital, advise, corticosteroid>, <phenytoin, mechanism, corticosteroids>, <phenytoin, advise, corticosteroid>, <rifampin, mechanism, corticosteroids>, <rifampin, advise, corticosteroid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance.", "output": "<troleandomycin, mechanism, corticosteroids>, <ketoconazole, mechanism, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticosteroids may increase the clearance of chronic high dose aspirin.", "output": "<Corticosteroids, effect, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn.", "output": "<salicylate, effect, corticosteroid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin should be used cautiously in conjunction with cortico-steroids in patients suffering from hypopro-thrombinemia.", "output": "<Aspirin, advise, cortico-steroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The effect of corticosteroids on oral anticoagulants is variable.", "output": "<corticosteroids, effect, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There are reports of enhanced as well as diminished effects of anticoagulants when given concurrently with corticosteroids.", "output": "<anticoagulants, effect, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of BOTOX and aminoglycosides or other agents interfering with neuromuscular transmission (e.g., curare-like compounds) should only be performed with caution as the effect of the toxin may be potentiated.", "output": "<BOTOX, advise, aminoglycosides>, <BOTOX, advise, curare-like compounds>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Excessive neuromuscular weakness may be exacerbated by administration of another botulinum toxin prior to the resolution of the effects of a previously administered botulinum toxin.", "output": "<botulinum toxin, effect, botulinum toxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Additive adverse effects resulting from cholinergic blockade may occur when LEVSIN is administered concomitantly with other antimuscarinics, amantadine, haloperidol, phenothiazines, monoamine oxidase (MAO) inhibitors, tricyclic antidepressants or some antihistamines.", "output": "<LEVSIN, effect, antimuscarinics>, <LEVSIN, effect, amantadine>, <LEVSIN, effect, haloperidol>, <LEVSIN, effect, phenothiazines>, <LEVSIN, effect, monoamine oxidase (MAO) inhibitors>, <LEVSIN, effect, tricyclic antidepressants>, <LEVSIN, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids may interfere with the absorption of LEVSIN.", "output": "<Antacids, mechanism, LEVSIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Fluvoxamine increased mean alosetron plasma concentrations (AUC) approximately 6-fold and prolonged the half-life by approximately 3-fold.", "output": "<Fluvoxamine, mechanism, alosetron>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of alosetron and fluvoxamine is contraindicated.", "output": "<alosetron, advise, fluvoxamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of alosetron and moderate CYP1A2 inhibitors, including quinolone antibiotics and cimetidine, has not been evaluated, but should be avoided unless clinically necessary because of similar potential drug interactions.", "output": "<alosetron, advise, quinolone antibiotics>, <alosetron, advise, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole increased mean alosetron plasma concentrations (AUC) by 29%.", "output": "<Ketoconazole, mechanism, alosetron>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be used when alosetron and ketoconazole are administered concomitantly.", "output": "<alosetron, advise, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of alosetron and strong CYP3A4 inhibitors, such as clarithromycin, telithromycin, protease inhibitors, voriconazole, and itraconazole has not been evaluated but should be undertaken with caution because of similar potential drug interactions.", "output": "<alosetron, advise, clarithromycin>, <alosetron, advise, telithromycin>, <alosetron, advise, protease inhibitors>, <alosetron, advise, voriconazole>, <alosetron, advise, itraconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although not studied with alosetron, inhibition of N-acetyltransferase may have clinically relevant consequences for drugs such as isoniazid, procainamide, and hydralazine.", "output": "<alosetron, effect, isoniazid>, <alosetron, effect, procainamide>, <alosetron, effect, hydralazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Adenosine: Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine.", "output": "<Dipyridamole, mechanism, adenosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cholinesterase Inhibitors: Dipyridamole may counteract the anticholinesterase effect of cholinesterase inhibitors, thereby potentially aggravating myasthenia gravis.", "output": "<Dipyridamole, effect, cholinesterase inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticholinergic agents: Although ipratropium bromide is minimally absorbed into the systemic circulation, there is some potential for an additive interaction with concomitantly used anticholinergic medications.", "output": "<ipratropium bromide, effect, anticholinergic medications>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution is therefore advised in the coadministration of ATROVENT Inhalation Aerosol with other anticholinergic-containing drugs.", "output": "<ATROVENT, advise, anticholinergic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "An encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN, and FBS) followed by irreversible brain damage has occurred in a few patients treated with lithium plus HALDOL.", "output": "<lithium, effect, HALDOL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "As with other antipsychotic agents, it should be noted that HALDOL may be capable of potentiating CNS depressants such as anesthetics, opiates, and alcohol.", "output": "<antipsychotic agents, effect, CNS depressants>, <antipsychotic agents, effect, anesthetics>, <antipsychotic agents, effect, opiates>, <antipsychotic agents, effect, alcohol>, <HALDOL, effect, CNS depressants>, <HALDOL, effect, anesthetics>, <HALDOL, effect, opiates>, <HALDOL, effect, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a study of 12 schizophrenic patients coadministered oral haloperidol and rifampin, plasma haloperidol levels were decreased by a mean of 70% and mean scores on the Brief Psychiatric Rating Scale were increased from baseline.", "output": "<haloperidol, mechanism, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In 5 other schizophrenic patients treated with oral haloperidol and rifampin, discontinuation of rifampin produced a mean 3.3-fold increase in haloperidol concentrations.", "output": "<rifampin, mechanism, haloperidol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus, careful monitoring of clinical status is warranted when rifampin is administered or discontinued in haloperidol-treated patients.", "output": "<rifampin, advise, haloperidol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "apomorphine - prior ingestion of diphenidol may decrease the emetic response to apomorphine in the treatment of poisoning.", "output": "<diphenidol, effect, apomorphine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a placebo-controlled trial in normal volunteers, the administration of a single 1 mg dose of doxazosin on day 1 of a four-day regimen of oral cimetidine (400 mg twice daily) resulted in a 10% increase in mean AUC of doxazosin (p=0.006), and a slight but not statistically significant increase in mean Cmax and mean half-life of doxazosin.", "output": "<doxazosin, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines.", "output": "<MAO inhibitors, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.", "output": "<Antihistamines, effect, alcohol>, <Antihistamines, effect, CNS depressants>, <Antihistamines, effect, hypnotics>, <Antihistamines, effect, sedatives>, <Antihistamines, effect, tranquilizers>, <Antihistamines, effect, antianxiety agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The addition of 540 mg/kg/day of cromolyn sodium (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) to 2.7 mg/kg/day of isoproterenol (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) appears to have increased the incidence of both resorptions and malformations.", "output": "<cromolyn sodium, effect, isoproterenol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "For example, since cholestyramine may reduce the gastrointestinal absorption of both the oral anticoagulants and vitamin K, the net effects are unpredictable.", "output": "<cholestyramine, mechanism, anticoagulants>, <cholestyramine, mechanism, vitamin K>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chloral hydrate may cause an increased prothrombin response by displacing the anticoagulant from protein binding sites or a diminished prothrombin response through increased metabolism of the unbound drug by hepatic enzyme induction, thus leading to inter-patient variation in ultimate prothrombin effect.", "output": "<Chloral hydrate, mechanism, anticoagulant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that have been reported to diminish oral anticoagulant response, ie, decreased prothrom-bin time response, in man significantly include: adrenocortical steroids;", "output": "<anticoagulant, effect, adrenocortical steroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that have been reported to diminish oral anticoagulant response, ie, decreased prothrom-bin time response, in man significantly include: adrenocortical steroids;alcohol*;antacids;antihistamines;barbiturates;carbamazepine;chloral hydrate*;chlordiazepoxide;cholestyramine;diet high in vitamin K;diuretics*;ethchlorvynol;glutethimide;griseofulvin;haloperidol;meprobamate;oral contraceptives;paraldehyde;primidone;ranitidine*;rifampin;unreliable prothrombin time determinations;vitamin C;warfarin sodium under-dosage.", "output": "<anticoagulant, effect, adrenocortical steroids>, <anticoagulant, effect, alcohol>, <anticoagulant, effect, antacids>, <anticoagulant, effect, antihistamines>, <anticoagulant, effect, barbiturates>, <anticoagulant, effect, carbamazepine>, <anticoagulant, effect, chloral hydrate>, <anticoagulant, effect, chlordiazepoxide>, <anticoagulant, effect, cholestyramine>, <anticoagulant, effect, vitamin K>, <anticoagulant, effect, diuretics>, <anticoagulant, effect, ethchlorvynol>, <anticoagulant, effect, glutethimide>, <anticoagulant, effect, griseofulvin>, <anticoagulant, effect, haloperidol>, <anticoagulant, effect, meprobamate>, <anticoagulant, effect, contraceptives>, <anticoagulant, effect, paraldehyde>, <anticoagulant, effect, primidone>, <anticoagulant, effect, ranitidine>, <anticoagulant, effect, rifampin>, <anticoagulant, effect, vitamin C>, <anticoagulant, effect, warfarin sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that reportedly may increase oral anticoagulant response, ie, increased prothrombin response, in man include:alcohol*;", "output": "<anticoagulant, effect, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that reportedly may increase oral anticoagulant response, ie, increased prothrombin response, in man include:alcohol*;allopurinol;aminosalicylic acid;amiodarone;anabolic steroids;antibiotics;bromelains;chloral hydrate*;chlorpropamide;chymotrypsin;cimetidine;cinchophen;clofibrate;dextran;dextrothyroxine;diazoxide;dietary deficiencies;diflunisal;disulfiram;drugs affecting blood elements;ethacrynic acid;fenoprofen;glucagon;hepatotoxic drugs;ibuprofen;indomethacin;influenza virus vaccine;inhalation anesthetics;mefenamic acid;methyldopa;methylphenidate;metronidazole;miconazole;monoamine oxidase inhibitors;nalidixic acid;naproxen;oxolinic acid;oxyphenbutazone;pentoxifylline;phenylbutazone;phenyramidol;phenytoin;prolonged hot weather;prolonged narcotics;pyrazolones;quinidine;quinine;ranitidine*;salicylates;sulfinpyrazone;sulfonamides, long acting;sulindac;thyroid drugs;tolbutamide;triclofos sodium;trimethoprim/sulfamethoxazole;unreliable prothrombin time determinations;warfarin sodium overdosage.", "output": "<anticoagulant, effect, alcohol>, <anticoagulant, effect, allopurinol>, <anticoagulant, effect, aminosalicylic acid>, <anticoagulant, effect, amiodarone>, <anticoagulant, effect, anabolic steroids>, <anticoagulant, effect, antibiotics>, <anticoagulant, effect, bromelains>, <anticoagulant, effect, chloral hydrate>, <anticoagulant, effect, chlorpropamide>, <anticoagulant, effect, chymotrypsin>, <anticoagulant, effect, cimetidine>, <anticoagulant, effect, cinchophen>, <anticoagulant, effect, clofibrate>, <anticoagulant, effect, dextran>, <anticoagulant, effect, dextrothyroxine>, <anticoagulant, effect, diazoxide>, <anticoagulant, effect, diflunisal>, <anticoagulant, effect, disulfiram>, <anticoagulant, effect, ethacrynic acid>, <anticoagulant, effect, fenoprofen>, <anticoagulant, effect, glucagon>, <anticoagulant, effect, ibuprofen>, <anticoagulant, effect, indomethacin>, <anticoagulant, effect, influenza virus vaccine>, <anticoagulant, effect, anesthetics>, <anticoagulant, effect, mefenamic acid>, <anticoagulant, effect, methyldopa>, <anticoagulant, effect, methylphenidate>, <anticoagulant, effect, metronidazole>, <anticoagulant, effect, miconazole>, <anticoagulant, effect, monoamine oxidase inhibitors>, <anticoagulant, effect, nalidixic acid>, <anticoagulant, effect, naproxen>, <anticoagulant, effect, oxolinic acid>, <anticoagulant, effect, oxyphenbutazone>, <anticoagulant, effect, pentoxifylline>, <anticoagulant, effect, phenylbutazone>, <anticoagulant, effect, phenyramidol>, <anticoagulant, effect, phenytoin>, <anticoagulant, effect, prolonged narcotics>, <anticoagulant, effect, pyrazolones>, <anticoagulant, effect, quinidine>, <anticoagulant, effect, quinine>, <anticoagulant, effect, ranitidine>, <anticoagulant, effect, salicylates>, <anticoagulant, effect, sulfinpyrazone>, <anticoagulant, effect, sulfonamides>, <anticoagulant, effect, sulindac>, <anticoagulant, effect, thyroid drugs>, <anticoagulant, effect, tolbutamide>, <anticoagulant, effect, triclofos sodium>, <anticoagulant, effect, trimethoprim>, <anticoagulant, effect, sulfamethoxazole>, <anticoagulant, effect, warfarin sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oral anticoagulants may potentiate the hypoglycemic action of hypoglycemic agents, eg, tolbutamide and chlorpropamide, by inhibiting their metabolism in the liver.", "output": "<anticoagulants, mechanism, hypoglycemic agents>, <anticoagulants, mechanism, tolbutamide>, <anticoagulants, mechanism, chlorpropamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because oral anticoagulants may interfere with the hepatic metabolism of phenytoin, toxic levels of the anticonvulsant may occur when an oral anticoagulant and phenytoin are administered concurrently.", "output": "<anticoagulants, mechanism, phenytoin>, <anticoagulant, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that reduce the number of blood platelets by causing bone marrow depression (such as antineoplastic agents) or drugs which inhibit platelet function (eg, aspirin and other non-steroidal anti-inflammatory drugs, dipyridamole, hydrochloroquine, clofibrate, dextran) may increase the bleeding tendency produced by anticoagulants without altering prothrombin time determinations.", "output": "<antineoplastic agents, effect, anticoagulants>, <aspirin, effect, anticoagulants>, <non-steroidal anti-inflammatory drugs, effect, anticoagulants>, <dipyridamole, effect, anticoagulants>, <hydrochloroquine, effect, anticoagulants>, <clofibrate, effect, anticoagulants>, <dextran, effect, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The beneficial effects on arterial thrombus formation from combined therapy with antiplatelet and anticoagulant medication must be weighed against an increased risk of inducing hemorrhage.", "output": "<antiplatelet medication, advise, anticoagulant medication>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of naltrexone with Acamprosate produced a 25% increase in AUC and a 33% increase in the Cmax of acamprosate.", "output": "<naltrexone, mechanism, Acamprosate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients taking Acamprosate concomitantly with antidepressants more commonly reported both weight gain and weight loss, compared with patients taking either medication alone.", "output": "<Acamprosate, effect, antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "All vasopressors should be used cautiously in patients taking monoamine oxidase (MAO) inhibitors.", "output": "<vasopressors, advise, monoamine oxidase (MAO) inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Epinephrine should not be administered concomitantly with other sympathomimetic drugs (such as isoproterenol) because of possible additive effects and increased toxicity.", "output": "<Epinephrine, advise, sympathomimetic drugs>, <Epinephrine, advise, isoproterenol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of epinephrine to patients receiving cyclopropane or halogenated hydrocarbon general anesthetics such as halothane which sensitize the myocardium, may induce cardiac arrhythmia..", "output": "<epinephrine, effect, cyclopropane>, <epinephrine, effect, halogenated hydrocarbon general anesthetics>, <epinephrine, effect, halothane>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Epinephrine also should be used cautiously with other drugs (e.g., digitalis, glycosides) that sensitize the myocardium to the actions of sympathomimetic drugs.", "output": "<Epinephrine, advise, digitalis>, <Epinephrine, advise, glycosides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diuretic agents may decrease vascular response to pressor drugs such as epinephrine.", "output": "<Diuretic agents, effect, epinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Epinephrine may antagonize the neuron blockade produced by guanethidine resulting in decreased antihypertensive effect and requiring increased dosage of the latter.", "output": "<Epinephrine, effect, guanethidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "CANCIDAS reduced the blood AUC0-12 of tacrolimus by approximately 20%, peak blood concentration (Cmax) by 16%, and 12-hour blood concentration (C12hr) by 26% in healthy subjects when tacrolimus (2 doses of 0.1 mg/kg 12 hours apart) was administered on the 10th day of CANCIDAS 70 mg daily, as compared to results from a control period in which tacrolimus was administered alone.", "output": "<CANCIDAS, mechanism, tacrolimus>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In two clinical studies, cyclosporine (one 4 mg/kg dose or two 3 mg/kg doses) increased the AUC of caspofungin by approximately 35%.", "output": "<cyclosporine, mechanism, caspofungin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There were transient increases in liver ALT and AST when CANCIDAS and cyclosporine were co-administered.", "output": "<CANCIDAS, effect, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A drug-drug interaction study with rifampin in healthy volunteers has shown a 30% decrease in caspofungin trough concentrations.", "output": "<rifampin, mechanism, caspofungin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients on rifampin should receive 70 mg of CANCIDAS daily.", "output": "<rifampin, advise, CANCIDAS>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition, results from regression analyses of patient pharmacokinetic data suggest that co-administration of other inducers of drug clearance (efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine) with CANCIDAS may result in clinically meaningful reductions in caspofungin concentrations.", "output": "<efavirenz, mechanism, CANCIDAS>, <nevirapine, mechanism, CANCIDAS>, <phenytoin, mechanism, CANCIDAS>, <dexamethasone, mechanism, CANCIDAS>, <carbamazepine, mechanism, CANCIDAS>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When CANCIDAS is co-administered with inducers of drug clearance, such as efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine, use of a daily dose of 70 mg of CANCIDAS should be considered", "output": "<CANCIDAS, advise, efavirenz>, <CANCIDAS, advise, nevirapine>, <CANCIDAS, advise, phenytoin>, <CANCIDAS, advise, dexamethasone>, <CANCIDAS, advise, carbamazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta-adrenergic blocking agents should be withdrawn at least 48 hours before conducting an arbutamine-mediated stress test.", "output": "<Beta-adrenergic blocking agents, advise, arbutamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.", "output": "<cephalosporins, effect, aminoglycoside antibiotics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticotropin may accentuate the electrolyte loss associated with diuretic therapy.", "output": "<Corticotropin, effect, diuretic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is possible that the cardiovascular action of other calcium channel blockers could be enhanced by the addition of Nimotop .", "output": "<calcium channel blockers, effect, Nimotop>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In Europe, Nimotop  was observed to occasionally intensify the effect of antihypertensive compounds taken concomitantly by patients suffering from hypertension;", "output": "<Nimotop, effect, antihypertensive compounds>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A study in eight healthy volunteers has shown a 50% increase in mean peak nimodipine plasma concentrations and a 90% increase in mean area under the curve, after a one week course of cimetidine at 1,000 mg/day and nimodipine at 90 mg/day.", "output": "<cimetidine, mechanism, nimodipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tablets: The benzodiazepines, including lorazepam, produce CNS-depressant effects when administered with such medications as barbiturates or alcohol.", "output": "<benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, alcohol>, <lorazepam, effect, barbiturates>, <lorazepam, effect, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Injection: Lorazepam injection, like other injectable benzodiazepines, produces depression of the central nervous system when administered with ethyl alcohol, phenothiazines, barbiturates, MAO inhibitors, and other antidepressants.When scopolamine is used concomitantly with injectable lorazepam, an increased incidence of sedation, hallucinations, and irrational behavior has been observed.", "output": "<Lorazepam, effect, ethyl alcohol>, <Lorazepam, effect, phenothiazines>, <Lorazepam, effect, barbiturates>, <Lorazepam, effect, MAO inhibitors>, <Lorazepam, effect, antidepressants>, <benzodiazepines, effect, ethyl alcohol>, <benzodiazepines, effect, phenothiazines>, <benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, MAO inhibitors>, <benzodiazepines, effect, antidepressants>, <scopolamine, effect, lorazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "(See CLINICAL PHARMACOLOGY) Coadministration of Femara and tamoxifen 20 mg daily resulted in a reduction of letrozole plasma levels by 38% on average.", "output": "<Femara, mechanism, tamoxifen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Codeine in combination with other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, or other CNS depressants (including alcohol) has additive depressant effects.", "output": "<Codeine, effect, narcotic analgesics>, <Codeine, effect, anesthetics>, <Codeine, effect, phenothiazines>, <Codeine, effect, tranquilizers>, <Codeine, effect, sedative-hypnotics>, <Codeine, effect, CNS depressants>, <Codeine, effect, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.", "output": "<SSRI, int, TCA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nevertheless, caution is indicated in the co-administration of TCAs with any of the SSRIs and also in switching from one class to the other.", "output": "<TCAs, advise, SSRIs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Inhibitors or substrates of CYP2D6 (i.e., quinidine, selective serotonin reuptake inhibitors [SSRIs]) may increase the plasma concentration of doxepin when administered concomitantly.", "output": "<quinidine, mechanism, doxepin>, <selective serotonin reuptake inhibitors, mechanism, doxepin>, <SSRIs, mechanism, doxepin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, MAO inhibitors should be discontinued at least two weeks prior to the cautious initiation of therapy with SINEQUAN.", "output": "<MAO inhibitors, advise, SINEQUAN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine: Cimetidine has been reported to produce clinically significant fluctuations in steady-state serum concentrations of various tricyclic antidepressants.", "output": "<Cimetidine, mechanism, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Serious anticholinergic symptoms (i.e., severe dry mouth, urinary retention and blurred vision) have been associated with elevations in the serum levels of tricyclic antidepressant when cimetidine therapy is initiated.", "output": "<tricyclic antidepressant, effect, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Additionally, higher than expected tricyclic antidepressant levels have been observed when they are begun in patients already taking cimetidine.", "output": "<tricyclic antidepressant, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients who have been reported to be well controlled on tricyclic antidepressants receiving concurrent cimetidine therapy, discontinuation of cimetidine has been reported to decrease established steady-state serum tricyclic antidepressant levels and compromise their therapeutic effects.", "output": "<cimetidine, mechanism, tricyclic antidepressant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Alcohol: It should be borne in mind that alcohol ingestion may increase the danger inherent in any intentional or unintentional SINEQUAN overdosage.", "output": "<alcohol, mechanism, SINEQUAN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tolazamide: A case of severe hypoglycemia has been reported in a type II diabetic patient maintained on tolazamide (1 gm/day) 11 days after the addition of doxepin (75 mg/day).", "output": "<tolazamide, effect, doxepin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Prolonged recovery time may occur if barbiturates and/or narcotics are used concurrently with ketamine.", "output": "<barbiturates, effect, ketamine>, <narcotics, effect, ketamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Isocarboxazid should be administered with caution to patients receiving Antabuse (disulfiram, Wyeth-Ayerst Laboratories).", "output": "<Isocarboxazid, advise, Antabuse>, <Isocarboxazid, advise, disulfiram>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a single study, rats given high intraperitoneal doses of an MAO inhibitor plus disulfiram experienced severe toxicity, including convulsions and death.", "output": "<MAO inhibitor, effect, disulfiram>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of Isocarboxazid and other psychotropic agents is generally not recommended because of possible potentiating effects.", "output": "<Isocarboxazid, advise, psychotropic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anesthetics/Sedatives/Hypnotics/Opioids: Co-administration of PRECEDEX with anesthetics, sedatives, hypnotics, and opioids is likely to lead to an enhancement of effects.", "output": "<PRECEDEX, effect, anesthetics>, <PRECEDEX, effect, sedatives>, <PRECEDEX, effect, hypnotics>, <PRECEDEX, effect, opioids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, due to possible pharmacodynamic interactions, when co-administered with PRECEDEX, a reduction in dosage of PRECEDEX on the concomitant anesthetic, sedative, hypnotic or opioid may be required.", "output": "<PRECEDEX, advise, anesthetic>, <PRECEDEX, advise, sedative>, <PRECEDEX, advise, hypnotic>, <PRECEDEX, advise, opioid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution is advised in patients receiving concomitant high-dose aspirin and carbonic anhydrase inhibitors, as anorexia, tachypnea, lethargy and coma have been rarely reported due to a possible drug interaction.", "output": "<aspirin, advise, carbonic anhydrase inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digoxin and verapamil use may be rarely associated with ventricular fibrillation when combined with Adenocard.", "output": "<Digoxin, effect, Adenocard>, <verapamil, effect, Adenocard>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The use of Adenocard in patients receiving digitalis may be rarely associated with ventricular fibrillation.", "output": "<Adenocard, effect, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The effects of adenosine are antagonized by methylxanthines such as caffeine and theophylline.", "output": "<adenosine, effect, methylxanthines>, <adenosine, effect, caffeine>, <adenosine, effect, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In the presence of these methylxanthines, larger doses of adenosine may be required or adenosine may not be effective.", "output": "<methylxanthines, advise, adenosine>, <methylxanthines, advise, adenosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Adenosine effects are potentiated by dipyridamole.", "output": "<Adenosine, effect, dipyridamole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus, smaller doses of adenosine may be effective in the presence of dipyridamole.", "output": "<adenosine, effect, dipyridamole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "As the primary effect of adenosine is to decrease conduction through the A-V node, higher degrees of heart block may be produced in the presence of carbamazepine.", "output": "<adenosine, effect, carbamazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine: In a study in healthy volunteers, a one-week course of cimetidine at 400 mg b.i.d. with a single 5 mg dose of isradipine on the sixth day showed an increase in isradipine mean peak plasma concentrations (36%) and significant increase in area under the curve (50%).", "output": "<cimetidine, mechanism, isradipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If isradipine therapy is initiated in a patient currently receiving cimetidine careful monitoring for adverse reactions is advised and downward dose adjustment may be required.", "output": "<isradipine, advise, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rifampicin: In a study in healthy volunteers, a six-day course of rifampicin at 600 mg/day followed by a single 5 mg dose of isradipine resulted in a reduction in isradipine levels to below detectable limits.", "output": "<rifampicin, mechanism, isradipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If rifampicin therapy is required, isradipine concentrations and therapeutic effects are likely to be markedly reduced or abolished as a consequence of increased metabolism and higher clearance of isradipine.", "output": "<rifampicin, mechanism, isradipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Fentanyl Anesthesia: Severe hypotension has been reported during fentanyl anesthesia with concomitant use of a beta blocker and a calcium channel blocker.", "output": "<fentanyl, effect, beta blocker>, <fentanyl, effect, calcium channel blocker>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs which induce CYP3A4 activity (eg, phenobarbital, rifampin, rifabutin) would be expected to increase the clearance of efavirenz resulting in lowered plasma concentrations.", "output": "<phenobarbital, mechanism, efavirenz>, <rifampin, mechanism, efavirenz>, <rifabutin, mechanism, efavirenz>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In uninfected volunteers, 46% developed rash while receiving SUSTIVA and clarithromycin.", "output": "<SUSTIVA, effect, clarithromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Increasing the indinavir dose to 1000 mg every 8 hours does not compensate for the increased indinavir metabolism due to SUSTIVA.", "output": "<indinavir, mechanism, SUSTIVA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When indinavir at an increased dose (1000 mg every 8 hours) was given with SUSTIVA (600 mg once daily), the indinavir AUC and Cmin were decreased on average by 33-46% and 39-57%, respectively, compared to when indinavir (800 mg every 8 hours) was given alone.", "output": "<indinavir, mechanism, SUSTIVA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A dose increase of lopinavir/ritonavir to 533/133 mg (4 capsules or 6.5 mL) twice daily taken with food is recommended when used in combination with SUSTIVA.", "output": "<lopinavir, advise, SUSTIVA>, <ritonavir, advise, SUSTIVA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because the potential interaction of efavirenz with oral contraceptives has not been fully characterized, a reliable method of barrier contraception should be used in addition to oral contraceptives.", "output": "<efavirenz, advise, contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Monitoring of liver enzymes is recommended when SUSTIVA is used in combination with ritonavir.", "output": "<SUSTIVA, advise, ritonavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Potential for reduction in anticonvulsant and/or efavirenz plasma levels;", "output": "<anticonvulsant, mechanism, efavirenz>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "SUSTIVA has the potential to decrease plasma concentrations of itraconazole and ketoconazole.", "output": "<SUSTIVA, mechanism, itraconazole>, <SUSTIVA, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Indinavir steady-state Cmax, A.C. and Cmin were decreased by 22%, 38%, and 27%, respectively, by concomitant amprenavir.", "output": "<Indinavir, mechanism, amprenavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Saquinavir steady-state Cmax, A.C. and Cmin were increased 21%, decreased 19%, and decreased 48%, respectively, by concomitant amprenavir.", "output": "<Saquinavir, mechanism, amprenavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nelfinavir steady-state Cmax, A.C. and Cmin were increased by 12%, 15%, and 14%, respectively, by concomitant amprenavir.", "output": "<Nelfinavir, mechanism, amprenavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methadone: Coadministration of amprenavir and methadone can decrease plasma levels of methadone.", "output": "<amprenavir, effect, methadone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of amprenavir and methadone as compared to a non-matched historicalcontrol group resulted in a 30%, 27%, and 25% decrease in serum amprenavir AUC, Cmax, andCmin, respectively.", "output": "<amprenavir, mechanism, methadone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Laboratory Tests: The combination of Amprenavir and low-dose ritonavir has been associated with elevations of cholesterol and triglycerides, SGOT (AST), and SGPT (ALT) in some patients.", "output": "<Amprenavir, effect, ritonavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Appropriate laboratory testing should be considered prior to initiating combination therapy with Amprenavir and ritonavir and at periodic intervals or if any clinical signs or symptoms of hyperlipidemia or elevated liver function tests occur during therapy.", "output": "<Amprenavir, advise, ritonavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticotropin may accentuate the electrolyte loss associated with diuretic therapy.", "output": "<Corticotropin, effect, diuretic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta-adrenergic Blocking Agents: Experience in over 1400 patients in a non-comparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension or exacerbation of angina.", "output": "<nifedipine, effect, beta-blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digitalis: Immediate Release Capsules: Since there have been isolated reports of patients with elevated digoxin levels, and there is a possible interaction between digoxin and nifedipine, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization.", "output": "<digoxin, int, nifedipine>, <digoxin, advise, nifedipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Extended Release Tablets: Administration of nifedipine with digoxin increased digoxin levels in 9 of 12 normal volunteers.", "output": "<digoxin, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since there have been isolated reports of patients with elevated digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization.", "output": "<digoxin, advise, nifedipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Quinidine: Immediate Release Capsules: There have been rare reports of an interaction between quinidine and nifedipine (with a decreased plasma level of quinidine).", "output": "<quinidine, mechanism, nifedipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coumarin Anticoagulants: There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered.", "output": "<coumarin anticoagulants, effect, nifedipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine: A study in 6 healthy volunteers has shown a significant increase in peak nifedipine plasma levels (80%) and area-under-the-curve (74%) after a 1 week course of cimetidine at 1000 mg per day and nifedipine at 40 mg per day.", "output": "<cimetidine, mechanism, nifedipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If nifedipine therapy is initiated in a patient currently receiving cimetidine, cautious titration is advised.", "output": "<nifedipine, advise, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins;", "output": "<Cholestyramine, mechanism, fat soluble vitamins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia.", "output": "<thiazides, effect, vitamin D>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias.", "output": "<Vitamin D, advise, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D.", "output": "<Ketoconazole, mechanism, vitamin D>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.", "output": "<vitamin D, effect, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.", "output": "<Magnesium, effect, vitamin D>, <antacids, effect, vitamin D>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In normal volunteers receiving indomethacin, the administration of diflunisal decreased the renal clearance and significantly increased the plasma levels of indomethacin.", "output": "<diflunisal, mechanism, indomethacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In some patients, combined use of INDOCIN and diflunisal has been associated with fatal gastrointestinal hemorrhage.", "output": "<INDOCIN, effect, diflunisal>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, diflunisal and INDOCIN should not be used concomitantly.", "output": "<diflunisal, advise, INDOCIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a study in normal volunteers, it was found that chronic concurrent administration of 3.6 g of aspirin per day decreases indomethacin blood levels approximately 20%.", "output": "<aspirin, mechanism, indomethacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant use of INDOCIN with other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy.", "output": "<INDOCIN, advise, NSAIDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, when any additional drug, including INDOCIN, is added to the treatment of patients on anticoagulant therapy, the patients should be observed for alterations of the prothrombin time.", "output": "<INDOCIN, advise, anticoagulant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In post-marketing experience, bleeding has been reported in patients on concomitant treatment with anticoagulants and INDOCIN.", "output": "<anticoagulants, effect, INDOCIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be exercised when INDOCIN and anticoagulants are administered concomitantly.", "output": "<INDOCIN, advise, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When INDOCIN is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased.", "output": "<INDOCIN, mechanism, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be used if INDOCIN is administered simultaneously with methotrexate.", "output": "<INDOCIN, advise, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "INDOCIN has been reported to decrease the tubular secretion of methotrexate and to potentiate its toxicity.", "output": "<INDOCIN, mechanism, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin.", "output": "<non-steroidal anti-inflammatory drugs, effect, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored.", "output": "<NSAIDs, advise, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Capsules INDOCIN 50 mg t.i.d. produced a clinically relevant elevation of plasma lithium and reduction in renal lithium clearance in psychiatric patients and normal subjects with steady state plasma lithium concentrations.", "output": "<INDOCIN, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "As a consequence, when INDOCIN and lithium are given concomitantly, the patient should be carefully observed for signs of lithium toxicity.", "output": "<INDOCIN, advise, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "INDOCIN given concomitantly with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.", "output": "<INDOCIN, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, when INDOCIN and digoxin are used concomitantly, serum digoxin levels should be closely monitored.", "output": "<INDOCIN, advise, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In some patients, the administration of INDOCIN can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics.", "output": "<INDOCIN, effect, loop diuretics>, <INDOCIN, effect, potassium-sparing diuretics>, <INDOCIN, effect, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It has been reported that the addition of triamterene to a maintenance schedule of INDOCIN resulted in reversible acute renal failure in two of four healthy volunteers.", "output": "<triamterene, effect, INDOCIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "INDOCIN and triamterene should not be administered together.", "output": "<INDOCIN, advise, triamterene>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The potential effects of INDOCIN and potassium-sparing diuretics on potassium kinetics and renal function should be considered when these agents are administered concurrently.", "output": "<INDOCIN, effect, potassium-sparing diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Most of the above effects concerning diuretics have been attributed, at least in part, to mechanisms involving inhibition of prostaglandin synthesis by INDOCIN.", "output": "<diuretics, effect, INDOCIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal antiinflammatory drugs including INDOCIN has been reported.", "output": "<beta-adrenoceptor blocking agents, effect, non-steroidal antiinflammatory drugs>, <beta-adrenoceptor blocking agents, effect, INDOCIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "INDOCIN can reduce the antihypertensive effects of captopril and losartan.", "output": "<INDOCIN, effect, captopril>, <INDOCIN, effect, losartan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with anastrozole (see CLINICAL PHARMACOLOGY   Drug Interactions and CLINICAL PHARMACOLOGY - Clinical Studies - Adjuvant Treatment of Breast Cancer in Postmenopausal Women subsections).", "output": "<tamoxifen, advise, anastrozole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of anastrozole and tamoxifen resulted in a reduction of anastrozole plasma levels by 27% compared with those achieved with anastrozole alone.", "output": "<anastrozole, mechanism, tamoxifen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Estrogen-containing therapies should not be used with ARIMIDEX as they may diminish its pharmacologic action.", "output": "<Estrogen, advise, ARIMIDEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chlorthalidone may add to or potentiate the action of other antihypertensive drugs.", "output": "<Chlorthalidone, effect, antihypertensive drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chlorthalidone and related drugs may increase the responsiveness to tubocurarine.", "output": "<Chlorthalidone, effect, tubocurarine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chlorthalidone and related drugs may decrease arterial responsiveness to norepinephrine.", "output": "<Chlorthalidone, effect, norepinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In another drug interaction study, co-administration of orally inhaled ciclesonide and oral ketoconazole, a potent inhibitor of cytochrome P450 3A4, increased the exposure (AUC) of des-ciclesonide by approximately 3.6-fold at steady state, while levels of ciclesonide remained unchanged.", "output": "<ciclesonide, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, ketoconazole should be administered with caution with intranasal ciclesonide.", "output": "<ketoconazole, advise, ciclesonide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If you are also using a steroid inhaler, take bitolterol first and then wait about 15 minutes before using the steroid inhaler.", "output": "<steroid, advise, bitolterol>, <bitolterol, advise, steroid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This allows bitolterol to open air passages, increasing the effectiveness of the steroid.", "output": "<bitolterol, effect, steroid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hypotension   Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, as well as those on severe dietary salt restriction or dialysis, may occasionally experience a precipitous reduction of blood pressure usually within the first hour after receiving the initial dose of captopril.", "output": "<diuretics, effect, captopril>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The possibility of hypotensive effects with captopril can be minimized by either discontinuing the diuretic or increasing the salt intake approximately one week prior to initiation of treatment with captopril (captopril tablets, USP) or initiating therapy with small doses (6.25 or 12.5 mg).", "output": "<captopril, effect, diuretic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "therefore, nitroglycerin or other nitrates (as used for management of angina) or other drugs having vasodilator activity should, if possible, be discontinued before starting captopril.", "output": "<nitroglycerin, advise, captopril>, <nitrates, advise, captopril>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Agents Causing Renin Release Captopril's effect will be augmented by antihypertensive agents that cause renin release.", "output": "<Captopril, effect, antihypertensive agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta-adrenergic blocking drugs add some further antihypertensive effect to captopril, but the overall response is less than additive.", "output": "<Beta-adrenergic blocking drugs, effect, captopril>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Inhibitors Of Endogenous Prostaglandin Synthesis It has been reported that indomethacin may reduce the antihypertensive effect of captopril, especially in cases of low renin hypertension.", "output": "<indomethacin, effect, captopril>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy.", "output": "<lithium, effect, ACE inhibitor>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If a diuretic is also used, it may increase the risk of lithium toxicity.", "output": "<diuretic, effect, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs which may enhance the neuromuscular blocking action of TRACRIUM include: enflurane;", "output": "<TRACRIUM, effect, enflurane>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs which may enhance the neuromuscular blocking action of TRACRIUM include: enflurane;isoflurane;halothane;certain antibiotics, especially the aminoglycosides and polymyxins;lithium;magnesium salts;procainamide;and quinidine.", "output": "<TRACRIUM, effect, enflurane>, <TRACRIUM, effect, isoflurane>, <TRACRIUM, effect, halothane>, <TRACRIUM, effect, antibiotics>, <TRACRIUM, effect, aminoglycosides>, <TRACRIUM, effect, polymyxins>, <TRACRIUM, effect, lithium>, <TRACRIUM, effect, magnesium>, <TRACRIUM, effect, procainamide>, <TRACRIUM, effect, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The prior administration of succinylcholine does not enhance the duration, but quickens the onset and may increase the depth, of neuromuscular block induced by TRACRIUM.", "output": "<succinylcholine, effect, TRACRIUM>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "TRACRIUM should not be administered until a patient has recovered from succinylcholine-induced neuromuscular block.", "output": "<TRACRIUM, advise, succinylcholine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Potential drug interactions for doxylamine include, increased sedation if doxylamine is combined with other CNS depressant drugs.", "output": "<doxylamine, effect, CNS depressant drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antihistamines may partially counteract the anticoagulation effects of heparin or warfarin.", "output": "<Antihistamines, effect, heparin>, <Antihistamines, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Doxylamine may enhance the effects of epinephrine.", "output": "<Doxylamine, effect, epinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The use of NSAIDs in patients who are receiving ACE inhibitors may potentiate renal disease states.", "output": "<NSAIDs, effect, ACE inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of naproxen and aspirin is not recommended because naproxen is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations and peak plasma levels.", "output": "<naproxen, advise, aspirin>, <naproxen, advise, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Naproxen and other NSAIDs can reduce the antihypertensive effect of propranolol and other beta-blockers.", "output": "<Naproxen, effect, propranolol>, <Naproxen, effect, beta-blockers>, <NSAIDs, effect, propranolol>, <NSAIDs, effect, beta-blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly.", "output": "<Probenecid, mechanism, naproxen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be used if naproxen is administered concomitantly with methotrexate.", "output": "<naproxen, advise, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Naproxen, naproxen sodium and other NSAIDs have been reported to reduce the tubular secretion of methotrexate in an animal model, possibly increasing the toxicity of methotrexate.", "output": "<Naproxen, mechanism, methotrexate>, <naproxen sodium, mechanism, methotrexate>, <NSAIDs, mechanism, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If CEFOTAN and an aminoglycoside are used concomitantly, renal function should be carefully monitored, because nephrotoxicity may be potentiated.", "output": "<CEFOTAN, effect, aminoglycoside>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Colchicine is inhibited by acidifying agents.", "output": "<Colchicine, mechanism, acidifying agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The action of colchicine is potentiated by alkalinizing agents.", "output": "<colchicine, mechanism, alkalinizing agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Colchicine may increase sensitivity to the CNS depressants.", "output": "<Colchicine, effect, CNS depressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Response to sympathomimetic agents may be enhanced by colchicine.", "output": "<sympathomimetic agents, effect, colchicine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anagrelide alone had no effect on platelet aggregation, but did slightly enhance the inhibition of platelet aggregation by aspirin.", "output": "<Anagrelide, effect, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is known that CYP1A2 is inhibited by several medicinal products, including fluvoxamine, and such medicinal products could theoretically adversely influence the clearance of anagrelide.", "output": "<fluvoxamine, mechanism, anagrelide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anagrelide demonstrates some limited inhibitory activity towards CYP1A2 which may present a theoretical potential for interaction with other coadministered medicinal products sharing that clearance mechanism e.g. theophylline.", "output": "<Anagrelide, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The effects of medicinal products with similar properties such as inotropes milrinone, enoximone, amrinone, olprinone and cilostazol may be exacerbated by anagrelide.", "output": "<milrinone, effect, anagrelide>, <enoximone, effect, anagrelide>, <amrinone, effect, anagrelide>, <olprinone, effect, anagrelide>, <cilostazol, effect, anagrelide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There is a single case report, which suggests that sucralfate may interfere with anagrelide absorption.", "output": "<sucralfate, mechanism, anagrelide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "FLUOTHANE augments the action of non-depolarising muscle relaxants and the muscle relaxant effects of aminoglycosides.", "output": "<FLUOTHANE, effect, non-depolarising muscle relaxant>, <FLUOTHANE, effect, aminoglycosides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "FLUOTHANE may augment the hypotension caused by the ganglionic-blocking effect of tubocurarine.", "output": "<FLUOTHANE, effect, tubocurarine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be exercised during the administration of adrenaline to patients anaesthetised with FLUOTHANE as arrhythmias may be precipitated.", "output": "<adrenaline, advise, FLUOTHANE>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Vitamin A: Because of the relationship of Accutane to vitamin A, patients should be advised against taking vitamin supplements containing vitamin A to avoid additive toxic effects", "output": "<Accutane, effect, vitamin A>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tetracyclines: Concomitant treatment with Accutane and tetracyclines should be avoided because Accutane use has been associated with a number of cases of pseudotumor cerebri (benign intracranial hypertension), some of which involved concomitant use of tetracyclines", "output": "<Accutane, advise, tetracyclines>, <Accutane, effect, tetracyclines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Micro-dosed Progesterone Preparations: Micro-dosed progesterone preparations (minipills that do not contain an estrogen) may be an inadequate method of contraception during Accutane therapy.", "output": "<progesterone, effect, Accutane>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents.", "output": "<reserpine, effect, beta-blocking>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine.", "output": "<beta-blockers, advise, clonidine>, <beta-blocker, advise, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function.", "output": "<calcium antagonists, advise, beta-adrenergic blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen.", "output": "<beta-adrenergic blocking agents, effect, calcium antagonist>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks.", "output": "<beta-blockers, effect, epinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The potential for increased sedation when guanfacine is given with other CNS-depressant drug should be appreciated.", "output": "<guanfacine, effect, CNS-depressant drug>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The administration of guanfacine concomitantly with known microsomal enzyme inducer (phenobarbital or phenytoin) to two patients with renal impairment reportedly resulted in significant reductions in elimination half-life and plasma concentration.", "output": "<guanfacine, mechanism, phenobarbital>, <guanfacine, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "TCAs decrease the hypotensive effect of guanfacine.", "output": "<TCAs, effect, guanfacine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Noncardioselective beta-blockers (nadolol,porpranolol,timolol) may exacerbate rebound hypertension when guanfacine is withdrawn.", "output": "<Noncardioselective beta-blockers, effect, guanfacine>, <nadolol, effect, guanfacine>, <timolol, effect, guanfacine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.", "output": "<SSRI, int, TCA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nevertheless, caution is indicated in the co-administration of T.A. with any of the SSRIs and also in switching from one class to the other.", "output": "<T.A., advise, SSRIs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If desipramine hydrochloride is to be combined with other psychotropic agents such as tranquilizers or sedative/hypnotics, careful consideration should be given to the pharmacology of the agents employed since the sedative effects of desipramine and benzodiazepines (e.g., chlordiazepoxide or diazepam) are additive.", "output": "<desipramine hydrochloride, effect, psychotropic agents>, <desipramine hydrochloride, effect, tranquilizers>, <desipramine hydrochloride, effect, sedative>, <desipramine hydrochloride, effect, hypnotics>, <desipramine, effect, benzodiazepines>, <desipramine, effect, chlordiazepoxide>, <desipramine, effect, diazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Both the sedative and anticholinergic effects of the major tranquilizers are also additive to those of desipramine.", "output": "<major tranquilizers, effect, desipramine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent administration of cimetidine and tricyclic antidepressants can produce clinically significant increases in the plasma levels of the tricyclic antidepressants.", "output": "<cimetidine, mechanism, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Conversely, decreases in plasma levels of the tricyclic antidepressants have been reported upon discontinuation of cimetidine which may result in the loss of the therapeutic efficacy of the tricyclic antidepressant 6.", "output": "<tricyclic antidepressants, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been greater than two-fold increases of previously stable plasma levels of tricyclic antidepressants when fluoxetine has been administered in combination with these agents.", "output": "<tricyclic antidepressants, mechanism, fluoxetine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "however, 150 mg of ranitidine q12h for 3 days increased the ceftibuten C max by 23% and ceftibuten AUC by 16%.", "output": "<ranitidine, mechanism, ceftibuten>, <ranitidine, mechanism, ceftibuten>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "FLEXERIL may have life-threatening interactions with MAO inhibitors.", "output": "<FLEXERIL, int, MAO inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants.", "output": "<FLEXERIL, effect, alcohol>, <FLEXERIL, effect, barbiturates>, <FLEXERIL, effect, CNS depressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tricyclic antidepressants may block the antihypertensive action of guanethidine and similarly acting compounds.", "output": "<Tricyclic antidepressants, effect, guanethidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tricyclic antidepressants may enhance the seizure risk in patients taking tramadol", "output": "<Tricyclic antidepressants, effect, tramadol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Urinary acidifying agents These agents (ammonium chloride, sodium acid phosphate, etc.) increase the concentration of the ionized species of the amphetamine molecule, thereby increasing urinary excretion.", "output": "<ammonium chloride, mechanism, amphetamine>, <sodium acid phosphate, mechanism, amphetamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Adrenergic blockers Adrenergic blockers are inhibited by amphetamines.", "output": "<Adrenergic blockers, effect, amphetamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antidepressants, tricyclic Amphetamines may enhance the activity of tricyclic antidepressants or sympathomimetic agents;", "output": "<Amphetamines, effect, tricyclic antidepressants>, <Amphetamines, effect, sympathomimetic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain;", "output": "<d-amphetamine, mechanism, desipramine>, <d-amphetamine, mechanism, protriptyline>, <d-amphetamine, mechanism, tricyclics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "MAO inhibitors MAOI antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism.", "output": "<MAOI antidepressants, mechanism, amphetamine>, <furazolidone, mechanism, amphetamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antihistamines: Amphetamines may counteract the sedative effect of antihistamines.", "output": "<Amphetamines, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antihypertensives: Amphetamines may antagonize the hypotensive effects of antihypertensives.", "output": "<Amphetamines, effect, antihypertensives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chlorpromazine: Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines and can be used to treat amphetamine poisoning.", "output": "<Chlorpromazine, effect, amphetamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ethosuximide: Amphetamines may delay intestinal absorption of ethosuximide.", "output": "<Amphetamines, mechanism, ethosuximide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Haloperidol: Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of amphetamines.", "output": "<Haloperidol, effect, amphetamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium carbonate: The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate.", "output": "<amphetamines, effect, lithium carbonate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Meperidine: Amphetamines potentiate the analgesic effect of meperidine.", "output": "<Amphetamines, effect, meperidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methenamine therapy Urinary excretion of amphetamines is increased, and efficacy is reduced by acidifying agents used in methenamine therapy.", "output": "<amphetamines, mechanism, methenamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Norepinephrine: Amphetamines enhance the adrenergic effect of norepinephrine.", "output": "<Amphetamines, effect, norepinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenobarbital: Amphetamines may delay intestinal absorption of phenobarbital;", "output": "<Amphetamines, mechanism, phenobarbital>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin: Amphetamines may delay intestinal absorption of phenytoin;", "output": "<Amphetamines, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Propoxyphene: In cases of propoxyphene overdosage, amphetamine CNS stimulation is potentiated and fatal convulsions can occur.", "output": "<propoxyphene, effect, amphetamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Veratrum alkaloids: Amphetamines inhibit the hypotensive effect of veratrum alkaloids.", "output": "<Amphetamines, effect, veratrum alkaloids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly.", "output": "<Intestinal adsorbents, mechanism, Acarbose>, <charcoal, mechanism, Acarbose>, <amylase, mechanism, Acarbose>, <pancreatin, mechanism, Acarbose>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment.", "output": "<Acarbose, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin.", "output": "<metformin, mechanism, Acarbose>, <Acarbose, mechanism, metformin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclopentolate may interfere with the anti-glaucoma action of carbachol or pilocarpine;", "output": "<Cyclopentolate, effect, carbachol>, <Cyclopentolate, effect, pilocarpine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-medications that induce CYP 3A4 (e.g., rifampicin, phenytoin, carbamazepine, phenobarbital, or St. John s wort) may significantly decrease exposure to exemestane.", "output": "<rifampicin, mechanism, exemestane>, <phenytoin, mechanism, exemestane>, <carbamazepine, mechanism, exemestane>, <phenobarbital, mechanism, exemestane>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A case report of one patient taking amiodarone 200 mg and indinavir 800 mg three times a day resulted in increases in amiodarone concentrations from 0.9 mg/L to 1.3 mg/L.", "output": "<amiodarone, mechanism, indinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Monitoring for amiodarone toxicity and serial measurement of amiodarone serum concentration during concomitant protease inhibitor therapy should be considered.", "output": "<amiodarone, advise, protease inhibitor>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Histamine H2 antagonists: Cimetidine inhibits CYP3A4 and can increase serum amiodarone levels.", "output": "<Histamine H2 antagonists, mechanism, Cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "On administration of oral amiodarone, the need for digitalis therapy should be reviewed and the dose reduced by approximately 50% or discontinued.", "output": "<amiodarone, advise, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nafazodone, fluvoxamine, cimetidine (consider Xanax dose reduction).", "output": "<Nafazodone, advise, Xanax>, <fluvoxamine, advise, Xanax>, <cimetidine, advise, Xanax>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of calcium supplements and L-lysine may increase calcium absorption", "output": "<calcium, mechanism, L-lysine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly within14 days following use of monoamine oxidase inhibitors.", "output": "<sympathomimetic amines, effect, monoamine oxidase inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "DIDREX should not be used concomitantly with other CNS stimulants.", "output": "<DIDREX, advise, CNS stimulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Amphetamines may decrease the hypotensive effect of antihypertensives.", "output": "<Amphetamines, effect, antihypertensives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Amphetamines may enhance the effects of tricyclic antidepressants.", "output": "<Amphetamines, effect, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Urinary acidifying agents decrease blood levels and increase excretion of amphetamines.", "output": "<Urinary acidifying, mechanism, amphetamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In one survey, 2.3% of patients taking labetalol HCl in combination with tricyclic antidepressants experienced tremor, as compared to 0.7% reported to occur with labetalol HCl alone.", "output": "<labetalol HCl, effect, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine has been shown to increase the bioavailability of labetalol HCl.", "output": "<Cimetidine, mechanism, labetalol HCl>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Synergism has been shown between halothane anesthesia and intravenously administered labetalol HCl.", "output": "<halothane, effect, labetalol HCl>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "During controlled hypotensive anesthesia using labetalol HCl in association with halothane, high concentrations (3% or above) of halothane should not be used because the degree of hypotension will be increased and because of the possibility of a large reduction in cardiac output and an increase in central venous pressure.", "output": "<labetalol HCl, effect, halothane>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Labetalol HCl blunts the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effect.", "output": "<Labetalol HCl, effect, nitroglycerin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If labetalol HCl is used with nitroglycerin in patients with angina pectoris, additional antihypertensive effects may occur.", "output": "<labetalol HCl, effect, nitroglycerin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Care should be taken if labetalol is used concomitantly with calcium antagonists of the verapamil type.", "output": "<labetalol, advise, calcium antagonist>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In clinical trials in patients undergoing PTCA/PCI, co-administration of Angiomax with heparin, warfarin, thrombolytics or glycoprotein IIb/IIIa inhibitors was associated with increased risks of major bleeding events compared to patients not receiving these concomitant medications.", "output": "<Angiomax, effect, heparin>, <Angiomax, effect, warfarin>, <Angiomax, effect, thrombolytics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension.", "output": "<epinephrine, effect, monoamine oxidase inhibitors>, <epinephrine, effect, tricyclic antidepressants>, <norepinephrine, effect, monoamine oxidase inhibitors>, <norepinephrine, effect, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine.", "output": "<Phenothiazines, effect, epinephrine>, <butyrophenones, effect, epinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drug Interactions with Beta-Blockers: Concomitant use of fenoldopam with beta-blockers should be avoided.", "output": "<fenoldopam, advise, beta-blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Apraclonidine should not be used in patients receiving MAO inhibitors..", "output": "<Apraclonidine, advise, MAO inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although no specific drug interactions with topical glaucoma drugs or systemic medications were identified in clinical studies of IOPIDINE 0.5% Ophthalmic Solution, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, anesthetics) should be considered.", "output": "<IOPIDINE, advise, CNS depressants>, <IOPIDINE, advise, alcohol>, <IOPIDINE, advise, barbiturates>, <IOPIDINE, advise, opiates>, <IOPIDINE, advise, sedatives>, <IOPIDINE, advise, anesthetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.", "output": "<Tricyclic antidepressants, effect, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "An additive hypotensive effect has been reported with the combination of systemic clonidine and neuroleptic therapy.", "output": "<clonidine, effect, neuroleptic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since apraclonidine may reduce pulse and blood pressure, caution in using drugs such as beta-blockers (ophthalmic and systemic), antihypertensives, and cardiac glycosides is advised.", "output": "<apraclonidine, advise, beta-blockers>, <apraclonidine, advise, antihypertensives>, <apraclonidine, advise, cardiac glycosides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When Bezalip or Bezalip retard is used at the same time as other medicines or substances the following interactions must be taken into account: - Bezalip and Bezalip retard may enhance the action of anticoagulants of the coumarin type.", "output": "<Bezalip, effect, anticoagulants of the coumarin type>, <Bezalip retard, effect, anticoagulants of the coumarin type>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "For this reason, the dose of the anticoagulant should be reduced by 30 - 50% at the start of treatment with Bezalip or Bezalip retard and then titrated according to the blood clotting parameters", "output": "<anticoagulant, advise, Bezalip>, <anticoagulant, advise, Bezalip>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- The action of sulphonylureas and insulin may be enhanced by Bezalip or Bezalip retard.", "output": "<sulphonylureas, effect, Bezalip>, <sulphonylureas, effect, Bezalip retard>, <insulin, effect, Bezalip>, <insulin, effect, Bezalip retard>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- In isolated cases, a pronounced though reversible, impairment of renal function (accompanied by a corresponding increase in the serum creatinine level) has been reported in organ transplant patients receiving immuno-suppressant therapy and concomitant bezafibrate.", "output": "<immuno-suppressant, effect, bezafibrate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- When Bezalip or Bezalip retard is used concurrently with anion-exchange resins (e.g. cholestryramine), an interval of at least 2 hours should be maintained between the two medicines, since the absorption of Bezalip or Bezalip retard is impaired", "output": "<Bezalip, advise, anion-exchange resins>, <Bezalip, advise, cholestryramine>, <Bezalip retard, advise, anion-exchange resins>, <Bezalip retard, advise, cholestryramine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Perhexiline hydrogen maleate or MAO-inhibitors (with hepatotoxic potential) must not be administered together with Bezalip or Bezalip retard.", "output": "<Perhexiline hydrogen maleate, advise, Bezalip>, <Perhexiline hydrogen maleate, advise, Bezalip retard>, <MAO-inhibitors, advise, Bezalip>, <MAO-inhibitors, advise, Bezalip retard>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although there are no study data to evaluate the possibility, nitric oxide donor compounds, including sodium nitroprusside and nitroglycerin, may have an additive effect with INOmax on the risk of developing methemoglobinemia.", "output": "<nitric oxide donor compounds, effect, INOmax>, <sodium nitroprusside, effect, INOmax>, <nitroglycerin, effect, INOmax>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant oral administration of ketoconazole (a known inhibitor of CYP3A4 activity in the liver and in the intestinal mucosa) caused an eight-fold increase of the systemic exposure to oral budesonide.", "output": "<ketoconazole, mechanism, budesonide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If treatment with inhibitors of CYP3A4 activity (such as ketoconazole, intraconazole, ritonavir, indinavir, saquinavir, erythromycin, etc.) is indicated, reduction of the budesonide dose should be considered.", "output": "<ketoconazole, advise, budesonide>, <intraconazole, advise, budesonide>, <ritonavir, advise, budesonide>, <indinavir, advise, budesonide>, <saquinavir, advise, budesonide>, <erythromycin, advise, budesonide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tagamet, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline and metronidazole, thereby delaying elimination and increasing blood levels of these drugs.", "output": "<Tagamet, mechanism, warfarin-type anticoagulants>, <Tagamet, mechanism, phenytoin>, <Tagamet, mechanism, propranolol>, <Tagamet, mechanism, nifedipine>, <Tagamet, mechanism, chlordiazepoxide>, <Tagamet, mechanism, diazepam>, <Tagamet, mechanism, tricyclic antidepressants>, <Tagamet, mechanism, lidocaine>, <Tagamet, mechanism, theophylline>, <Tagamet, mechanism, metronidazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "therefore, close monitoring of prothrombin time is recommended, and adjustment of the anticoagulant dose may be necessary when Tagamet is administered concomitantly.", "output": "<anticoagulant, advise, Tagamet>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, a crossover study in healthy subjects receiving either Tagamet 300 mg q.i.d. or 800 mg h.s. concomitantly with a 300 mg b.i.d. dosage of theophylline (Theo-Dur , Key Pharmaceuticals, Inc.) demonstrated less alteration in steady-state theophylline peak serum levels with the 800 mg h.s. regimen, particularly in subjects aged 54 years and older.", "output": "<Tagamet, mechanism, theophylline>, <Tagamet, mechanism, Theo-Dur>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of ELLENCE with other cardioactive compounds that could cause heart failure (e.g., calcium channel blockers), requires close monitoring of cardiac function throughout treatment.", "output": "<ELLENCE, advise, calcium channel blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine increased the AUC of epirubicin by 50%.", "output": "<Cimetidine, mechanism, epirubicin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine treatment should be stopped during treatment with ELLENCE.", "output": "<Cimetidine, advise, ELLENCE>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "MAO inhibitors prolong and intensify the effects of antihistamines.", "output": "<MAO inhibitors, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of antihistamines with alcohol, tricyclic antidepressants, barbiturates, or other central nervous system depressants may have an additive effect.", "output": "<antihistamines, effect, alcohol>, <antihistamines, effect, tricyclic antidepressants>, <antihistamines, effect, barbiturates>, <antihistamines, effect, central nervous system depressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When sympathomimetic drugs are given to patients receiving monoamine oxidase inhibitors, hypertensive reactions, including hypertensive crises, may occur.", "output": "<sympathomimetic drugs, effect, monoamine oxidase inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The antihypertensive effects of methyldopa, mecamylamine, reserpine, and veratrum alkaloids may be reduced by sympathomimetics.", "output": "<methyldopa, effect, sympathomimetics>, <mecamylamine, effect, sympathomimetics>, <reserpine, effect, sympathomimetics>, <veratrum alkaloids, effect, sympathomimetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta-adrenergic blocking agents may also interact with sympathomimetics.", "output": "<Beta-adrenergic blocking agents, int, sympathomimetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Increased ectopic pacemaker activity can occur when pseudoephedrine is used concomitantly with digitalis.", "output": "<pseudoephedrine, effect, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids increase the rate of absorption of pseudoephedrine, while kaolin decreases it.", "output": "<Antacids, mechanism, pseudoephedrine>, <pseudoephedrine, mechanism, kaolin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dexbrompheniramine can interact with alcohol or other CNS depressants (may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).", "output": "<Dexbrompheniramine, int, alcohol>, <Dexbrompheniramine, int, CNS depressants>, <Dexbrompheniramine, int, anticholinergics>, <Dexbrompheniramine, int, monoamine oxidase (MAO) inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a Phase I trial using escalating doses of TAXOL (110-200 mg/m2) and cisplatin (50 or 75 mg/m2) given as sequential infusions, myelosuppression was more profound when TAXOL was given after cisplatin than with the alternate sequence (ie, TAXOL before cisplatin).", "output": "<TAXOL, effect, cisplatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pharmacokinetic data from these patients demonstrated a decrease in paclitaxel clearance of approximately 33% when TAXOL was administered following cisplatin.", "output": "<TAXOL, mechanism, cisplatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Reports in the literature suggest that plasma levels of doxorubicin (and its active metabolite doxorubicinol) may be increased when paclitaxel and doxorubicin are used in combination.", "output": "<paclitaxel, mechanism, doxorubicin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hypersensitivity Reactions: Patients with a history of severe hypersensitivity reactions to products containing Cremophor  EL (eg, cyclosporin for injection concentrate and teniposide for injection concentrate) should not be treated with TAXOL.", "output": "<cyclosporin, advise, TAXOL>, <teniposide, advise, TAXOL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Immediate and Extended Release Tablets The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, some azoles and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents.", "output": "<sulfonylureas, effect, nonsteroidal anti-inflammatory agents>, <sulfonylureas, effect, azoles>, <sulfonylureas, effect, salicylates>, <sulfonylureas, effect, sulfonamides>, <sulfonylureas, effect, chloramphenicol>, <sulfonylureas, effect, probenecid>, <sulfonylureas, effect, coumarins>, <sulfonylureas, effect, monoamine oxidase inhibitors>, <sulfonylureas, effect, beta adrenergic blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported.", "output": "<miconazole, int, hypoglycemic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The effect of concomitant administration of fluconazole and glipizide has been demonstrated in a placebo-controlled crossover study in normal volunteers.", "output": "<fluconazole, int, glipizide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The mean percentage increase in the glipizide AUC after fluconazole administration was 56.9% (range: 35 to 81).", "output": "<glipizide, mechanism, fluconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Interactions may occur with the following: adrenocorticoids (cortisone-like medicine), anticoagulants (blood thinners), carbamazepine, corticotropin (barbiturates may decrease the effects of these medicines), central nervous system (CNS) depressants (using these medicines with barbiturates may result in increased CNS depressant effects), divalproex sodium, valproic acid (using these medicines with barbiturates may change the amount of either medicine that you need to take), and oral contraceptives containing estrogens (barbiturates may decrease the effectiveness of these oral contraceptives, and you may need to change to a different type of birth control).", "output": "<barbiturates, effect, contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ACE-inhibitors Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors.", "output": "<NSAIDs, effect, ACE-inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.", "output": "<NSAIDs, advise, ACE-inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: When Lodine is administered with aspirin, its protein binding is reduced, although the clearance of free etodolac is not altered.", "output": "<Lodine, mechanism, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "however, as with other NSAIDs, concomitant administration of Lodine and aspirin is not generally recommended because of the potential of increased adverse effects.", "output": "<Lodine, advise, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporine, Digoxin, Methotrexate Lodine, like other NSAIDs, through effects on renal prostaglandins, may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine, digoxin, methotrexate, and increased toxicity.", "output": "<Lodine, mechanism, cyclosporine>, <Lodine, mechanism, digoxin>, <Lodine, mechanism, methotrexate>, <NSAIDs, mechanism, cyclosporine>, <NSAIDs, mechanism, digoxin>, <NSAIDs, mechanism, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nevertheless, clinical studies, as well as postmarketing observations have shown that Lodine can reduce the natriuretic effect of furosemide and thiazides in some patients.", "output": "<Lodine, effect, furosemide>, <Lodine, effect, thiazides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.", "output": "<NSAIDs, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.", "output": "<NSAIDs, effect, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenylbutazone: Phenylbutazone causes increase (by about 80%) in the free fraction of etodolac.", "output": "<Phenylbutazone, mechanism, etodolac>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although in vivo studies have not been done to see if etodolac clearance is changed by coadministration of phenylbutazone, it is not recommended that they be coadministered.", "output": "<etodolac, advise, phenylbutazone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than that of users of either drug alone.", "output": "<warfarin, effect, NSAIDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Short-term pharmacokinetic studies have demonstrated that concomitant administration of warfarin and Lodine  (etodolac capsules and tablets) results in reduced protein binding of warfarin, but there was no change in the clearance of free warfarin.", "output": "<warfarin, mechanism, Lodine>, <warfarin, mechanism, etodolac>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, caution should be exercised because there have been a few spontaneous reports of prolonged prothrombin times, with or without bleeding, in etodolac-treated patients receiving concomitant warfarin therapy.", "output": "<etodolac, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients given very high doses (3900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently.", "output": "<aspirin, mechanism, nizatidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If additional adrenergic drugs are to be administered by any route, they should be used with caution because the pharmacologically predictable sympathetic effects of BROVANA may be potentiated.", "output": "<adrenergic drugs, advise, BROVANA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant treatment with methylxanthines (aminophylline, theophylline), steroids, or diuretics may potentiate any hypokalemic effect of adrenergic agonists.", "output": "<methylxanthines, effect, adrenergic agonists>, <aminophylline, effect, adrenergic agonists>, <theophylline, effect, adrenergic agonists>, <steroids, effect, adrenergic agonists>, <diuretics, effect, adrenergic agonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The ECG changes and/or hypokalemia that may result from the administration of non-potassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded.", "output": "<non-potassium sparing diuretics, effect, beta-agonists>, <loop diuretics, effect, beta-agonists>, <thiazide diuretics, effect, beta-agonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although the clinical significance of these effects is not known, caution is advised in the co-administration of beta-agonists with non-potassium sparing diuretics.", "output": "<beta-agonists, advise, non-potassium sparing diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "BROVANA, as with other beta2-agonists, should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors, tricyclic antidepressants, or drugs known to prolong the QTc interval because the action of adrenergic agonists on the cardiovascular system may be potentiated by these agents.", "output": "<BROVANA, advise, monoamine oxidase inhibitors>, <BROVANA, advise, tricyclic antidepressants>, <beta2-agonists, advise, monoamine oxidase inhibitors>, <beta2-agonists, advise, tricyclic antidepressants>, <monoamine oxidase inhibitors, effect, adrenergic agonists>, <tricyclic antidepressants, effect, adrenergic agonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta-adrenergic receptor antagonists (beta-blockers) and BROVANA may interfere with the effect of each other when administered concurrently.", "output": "<Beta-adrenergic receptor antagonists, effect, BROVANA>, <beta-blockers, effect, BROVANA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta-blockers not only block the therapeutic effects of beta-agonists, but may produce severe bronchospasm in COPD patients.", "output": "<Beta-blockers, effect, beta-agonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Additive CNS depression may occur when antihistamines are administered concomitantly with other CNS depressants including barbiturates, tranquilizers, and alcohol.", "output": "<antihistamines, effect, CNS depressants>, <antihistamines, effect, barbiturates>, <antihistamines, effect, tranquilizers>, <antihistamines, effect, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients receiving antihistamines should be advised against the concurrent use of other CNS depressant drugs.", "output": "<antihistamines, advise, CNS depressant drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Monoamine oxidase (MAO) inhibitors prolong and intensify the anticholinergic effects of antihistamines.", "output": "<Monoamine oxidase (MAO) inhibitors, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of doxapram to patients who are receiving sympathomimetic or monoamine oxidase inhibiting drugs may result in an additive pressor effect .", "output": "<doxapram, effect, sympathomimetic>, <doxapram, effect, monoamine oxidase inhibiting drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients who have received muscle relaxants, doxapram may temporarily mask the residual effects of muscle relaxant drugs.", "output": "<doxapram, effect, muscle relaxant drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The effects of ERGOMAR may be potentiated by triacetyloleandomycin which inhibits the metabolism of ergotamine.", "output": "<ERGOMAR, mechanism, triacetyloleandomycin>, <triacetyloleandomycin, mechanism, ergotamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The pressor effects of ERGOMAR and other vasoconstrictor drugs can combine to cause dangerous hypertension.", "output": "<ERGOMAR, effect, vasoconstrictor drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Synergism between xanthine bronchodilators (e.g., theophylline), ephedrine, and other sympathomimetic bronchodilators has been reported.", "output": "<xanthine bronchodilators, effect, sympathomimetic bronchodilators>, <theophylline, effect, sympathomimetic bronchodilators>, <ephedrine, effect, sympathomimetic bronchodilators>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent administration of dyphylline and probenecid, which competes for tubular secretion, has been shown to increase the plasma half-life of dyphylline .", "output": "<dyphylline, mechanism, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, in patients treated with oral carbonic anhydrase inhibitors, rare instances of drug interactions have occurred with high-dose salicylate therapy.", "output": "<carbonic anhydrase inhibitors, int, salicylate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Effect of AEDs in Pediatric Patients There was about a 22% increase of apparent total body clearance of levetiracetam when it was co-administered with enzyme-inducing AEDs.", "output": "<levetiracetam, mechanism, AEDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When ertapenem is co-administered with probenecid (500 mg p.o. every 6 hours), probenecid competes for active tubular secretion and reduces the renal clearance of ertapenem.", "output": "<probenecid, mechanism, ertapenem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Based on total ertapenem concentrations, probenecid increased the AUC by 25% and reduced the plasma and renal clearances by 20% and 35%, respectively.", "output": "<ertapenem, mechanism, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because of the small effect on half-life, the coadministration with probenecid to extend the half-life of ertapenem is not recommended.", "output": "<probenecid, advise, ertapenem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Using calcium acetate with digitalis glycosides (heart medicine) may cause hypercalcemia (too much calcium in the blood), which could increase the chance of developing an irregular heartbeat.", "output": "<calcium acetate, effect, digitalis glycosides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "On the basis of the metabolism of bexarotene by cytochrome P450 3A4, ketoconazole, itraconazole, erythromycin, gemfibrozil, grapefruit juice, and other inhibitors of cytochrome P450 3A4 would be expected to lead to an increase in plasma bexarotene concentrations.", "output": "<ketoconazole, mechanism, bexarotene>, <itraconazole, mechanism, bexarotene>, <erythromycin, mechanism, bexarotene>, <gemfibrozil, mechanism, bexarotene>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furthermore, rifampin, phenytoin, phenobarbital, and other inducers of cytochrome P450 3A4 may cause a reduction in plasma bexarotene concentrations.", "output": "<rifampin, mechanism, bexarotene>, <phenytoin, mechanism, bexarotene>, <phenobarbital, mechanism, bexarotene>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of Targretin capsules and gemfibrozil resulted in substantial increases in plasma concentrations of bexarotene, probably at least partially related to cytochrome P450 3A4 inhibition by gemfibrozil.", "output": "<Targretin, mechanism, gemfibrozil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of gemfibrozil with Targretin capsules is not recommended.", "output": "<gemfibrozil, advise, Targretin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If phenytoin or other hepatic enzyme inducers are taken concurrently with Norpace or Norpace CR, lower plasma levels of disopyramide may occur.", "output": "<phenytoin, mechanism, Norpace>, <phenytoin, mechanism, Norpace CR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of Norpace and quinidine resulted in slight increases in plasma disopyramide levels and slight decreases in plasma quinidine levels.", "output": "<Norpace, mechanism, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients taking disopyramide phosphate and erythromycin concomitantly may develop increased serum concentrations of disopyramide resulting in excessive widening of the QRS complex and/or prolongation of the Q-T interval.", "output": "<disopyramide phosphate, mechanism, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Until data on possible interactions between verapamil and disopyramide phosphate are obtained, disopyramide should not be administered within 48 hours before or 24 hours after verapamil administration.", "output": "<disopyramide, advise, verapamil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Taking amyl nitrite after drinking alcohol may worsen side effects and may cause severe hypotension and cardiovascular collapse.", "output": "<amyl nitrite, effect, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "5HT3 Antagonists: Based on reports of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron, the concomitant use of apomorphine with drugs of the 5HT3 antagonist class (including, for example, ondansetron, granisetron, dolasetron, palonosetron, and alosetron) is contraindicated .", "output": "<apomorphine, effect, ondansetron>, <apomorphine, advise, 5HT3 antagonist class>, <apomorphine, advise, ondansetron>, <apomorphine, advise, granisetron>, <apomorphine, advise, dolasetron>, <apomorphine, advise, palonosetron>, <apomorphine, advise, alosetron>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antihypertensive Medications and Vasodilators: The following adverse events were experienced more commonly in patients receiving concomitant antihypertensive medications or vasodilators (n = 94) compared to patients not receiving these concomitant drugs (n = 456): hypotension 10% vs 4%, myocardial infarction 3% vs 1%, serious pneumonia 5% vs 3%, serious falls 9% vs 3%, and bone and joint injuries 6% vs 2%.", "output": "<antihypertensive medications, effect, vasodilators>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dopamine Antagonists: Since apomorphine is a dopamine agonist, it is possible that dopamine antagonists, such as the neuroleptics (phenothiazines, butyrophenones, thioxanthenes) or metoclopramide, may diminish the effectiveness of APOKYN.", "output": "<dopamine antagonists, effect, metoclopramide>, <phenothiazines, effect, APOKYN>, <butyrophenones, effect, APOKYN>, <thioxanthenes, effect, APOKYN>, <metoclopramide, effect, APOKYN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients with major psychotic disorders, treated with neuroleptics, should be treated with dopamine agonists only if the potential benefits outweigh the risks.", "output": "<neuroleptics, advise, dopamine agonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension.", "output": "<epinephrine, effect, monoamine oxidase inhibitors>, <epinephrine, effect, tricyclic antidepressants>, <norepinephrine, effect, monoamine oxidase inhibitors>, <norepinephrine, effect, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine.", "output": "<Phenothiazines, effect, epinephrine>, <butyrophenones, effect, epinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drug-Drug Interactions Given the primary CNS effects of aripiprazole, caution should be used when ABILIFY is taken in combination with other centrally acting drugs and alcohol.", "output": "<ABILIFY, advise, centrally acting drugs>, <ABILIFY, advise, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "1- adrenergic receptor antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents.", "output": "<aripiprazole, effect, antihypertensive agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Agents that induce CYP3A4 (eg, carbamazepine) could cause an increase in aripiprazole clearance and lower blood levels.", "output": "<carbamazepine, mechanism, aripiprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit aripiprazole elimination and cause increased blood levels.", "output": "<ketoconazole, mechanism, aripiprazole>, <quinidine, mechanism, aripiprazole>, <fluoxetine, mechanism, aripiprazole>, <paroxetine, mechanism, aripiprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: Coadministration of ketoconazole (200 mg/day for 14 days) with a 15-mg single dose of aripiprazole increased the AUC of aripiprazole and its active metabolite by 63% and 77%, respectively.", "output": "<ketoconazole, mechanism, aripiprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When concomitant administration of ketoconazole with aripiprazole occurs, aripiprazole dose should be reduced to one-half of its normal dose.", "output": "<ketoconazole, advise, aripiprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Quinidine: Coadministration of a 10-mg single dose of aripiprazole with quinidine (166 mg/day for 13 days), a potent inhibitor of CYP2D6, increased the AUC of aripiprazole by 112% but decreased the AUC of its active metabolite, dehydroaripiprazole, by 35%.", "output": "<aripiprazole, mechanism, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aripiprazole dose should be reduced to one-half of its normal dose when concomitant administration of quinidine with aripiprazole occurs.", "output": "<quinidine, advise, aripiprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Carbamazepine: Coadministration of carbamazepine (200 mg BID), a potent CYP3A4 inducer, with aripiprazole (30 mg QD) resulted in an approximate 70% decrease in Cmax and AUC values of both aripiprazole and its active metabolite, dehydro-aripiprazole.", "output": "<carbamazepine, mechanism, aripiprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When carbamazepine is added to aripiprazole therapy, aripiprazole dose should be doubled.", "output": "<carbamazepine, advise, aripiprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When carbamazepine is withdrawn from the combination therapy, aripiprazole dose should then be reduced.", "output": "<carbamazepine, advise, aripiprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "As with most psychoactive medications, patients should be advised to avoid alcohol while taking ABILIFY", "output": "<alcohol, advise, ABILIFY>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dexbrompheniramine can interact with alcohol or other CNS depressants (may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).", "output": "<Dexbrompheniramine, effect, alcohol>, <Dexbrompheniramine, effect, CNS depressants>, <Dexbrompheniramine, effect, anticholinergics>, <Dexbrompheniramine, effect, monoamine oxidase (MAO) inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cholestyramine-Concomitant intake of cholestyramine and vitamin K may reduce the absorption of vitamin K.", "output": "<cholestyramine, mechanism, vitamin K>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Colestipol-Concomitant intake of colestipol and vitamin K may reduce the absorption of vitamin K.", "output": "<colestipol, mechanism, vitamin K>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Mineral Oil-Concomitant intake of mineral oil and vitamin K may reduce the absorption of vitamin K.", "output": "<mineral oil, mechanism, vitamin K>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Orlistat-Orlistat may decrease the absorption of vitamin K.", "output": "<Orlistat, mechanism, vitamin K>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin-Vitamin K can antagonize the effect of warfarin", "output": "<Vitamin K, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticoagulants: Flurbiprofen like other nonsteroidal anti-inflammatory drugs, has been shown to affect bleeding parameters in patients receiving anti-coagulants, and serious clinical bleeding has been reported.", "output": "<Flurbiprofen, effect, anti-coagulants>, <nonsteroidal anti-inflammatory drugs, effect, anti-coagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The physician should be cautious when administering flurbiprofen to patients taking anticoagulants.", "output": "<flurbiprofen, advise, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: Concurrent administration of aspirin and flurbiprofen resulted in 50% lower serum flurbiprofen concentrations.", "output": "<aspirin, mechanism, flurbiprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent use of flurbiprofen and aspirin is therefore not recommended.", "output": "<flurbiprofen, advise, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Flurbiprofen pretreatment attenuated the hypotensive effect of a single dose of propranolol but not atenolol.", "output": "<Flurbiprofen, effect, propranolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Flurbiprofen did not affect the pharmacokinetic profile of either drug, and the mechanism under lying the interference with propranolols hypotensive effect is unknown.", "output": "<Flurbiprofen, int, propranolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients taking both flurbiprofen and a beta-blocker should be monitored to ensure that a satisfactory hypotensive effect is achieved.", "output": "<flurbiprofen, advise, beta-blocker>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine, Ranitidine: In normal volunteers (n=9), pretreatment with cimetidine or ranitidine did not affect flurbiprofen pharmacokinetics except that a small (13 %) but statistically significant increase in the area under the serum concentration curve of flurbiprofen resulted with cimetidine.", "output": "<flurbiprofen, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diuretics: Studies in normal volunteers have shown that flurbiprofen like other nonsteroidal anti-inflammatory drugs, can interfere with the effects of furosemide.", "output": "<flurbiprofen, effect, furosemide>, <nonsteroidal anti-inflammatory drugs, effect, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other nonsteroidal anti-inflammatory drugs that inhibit prostaglandin synthesis have been shown to interfere with thiazide diuretics in some studies and with potassium-sparing diuretics.", "output": "<nonsteroidal anti-inflammatory drugs, effect, thiazide diuretics>, <nonsteroidal anti-inflammatory drugs, effect, potassium-sparing diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients receiving flurbiprofen and furosemide or other diuretics should be observed closely to determine if the desired effect is obtained.", "output": "<flurbiprofen, advise, furosemide>, <flurbiprofen, advise, diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although there was a slight reduction in blood sugar concentrations during concomitant administration of flurbiprofen and hypoglycemic agents, there were no signs or symptoms of hypoglycemia.", "output": "<flurbiprofen, effect, hypoglycemic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "DISULFIRAM SHOULD BE USED WITH CAUTION IN THOSE PATIENTS REVEIVING PHENYTOIN AND ITS CONGENERS.", "output": "<DISULFIRAM, advise, PHENYTOIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "SINCE THE CONCOMITANT ADMINISTRATION OF THESE TWO DRUGS CAN LEAD TO PHENYTOIN INTOXICATION, PRIOR TO ADMINISTERING DISULFIRAM TO A PATIENT ON PHENYTOIN THERAPY, A BASELINE PHENYTOIN SERUM LEVEL SHOULD BE OBTAINED.", "output": "<DISULFIRAM, effect, PHENYTOIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It may be necessary to adjust the dosage of oral anticoagulants upon beginning or stopping disulfiram. since disulfiram may prolong prothrombin time.", "output": "<anticoagulants, advise, disulfiram>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients taking isoniazid when disulfiram is given should be observed for the appearance of unsteady gait or marked changes in mental status;", "output": "<isoniazid, advise, disulfiram>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In rats, simultaneous ingestion of disulfiram and nitrite in the diet for 78 weeks has been reported to cause tumors, and it has been suggested that disulfiram may react with nitrites in the rat stomach to form a nitrosamine, which is tumorigenic.", "output": "<disulfiram, effect, nitrite>, <disulfiram, effect, nitrites>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A 30 to 45% increase in AUC and Cmax of nisoldipine was observed with concomitant administration of cimetidine 400 mg twice daily.", "output": "<nisoldipine, mechanism, cimetidine 400 mg>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of phenytoin with 40 mg SULAR tablets in epileptic patients lowered the nisoldipine plasma concentrations to undetectable levels.", "output": "<phenytoin, mechanism, SULAR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of SULAR with phenytoin or any known CYP3A4 inducer should be avoided and alternative antihypertensive therapy should be considered.", "output": "<SULAR, advise, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Propranolol attenuated the heart rate increase following administration of immediate release nisoldipine.", "output": "<Propranolol, effect, nisoldipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The blood pressure effect of SULAR tended to be greater in patients on atenolol than in patients on no other antihypertensive therapy.", "output": "<SULAR, effect, atenolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Quinidine at 648 mg bid decreased the bioavailability (AUC) of nisoldipine by 26%, but not the peak concentration.", "output": "<Quinidine, mechanism, nisoldipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The immediate release, but not the coat-core formulation of nisoldipine increased plasma quinidine concentrations by about 20%.", "output": "<nisoldipine, mechanism, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended that buspirone hydrochloride not be used concomitantly with MAO inhibitors Because the effects of concomitant administration of buspirone HCl with most other psychotropic drugs have not been studied, the concomitant use of buspirone HCl with other CNS-active drugs should be approached with caution.", "output": "<buspirone hydrochloride, advise, MAO inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There is one report suggesting that the concomitant use of trazodone hydrochloride (Desyrel) and buspirone HCl may have caused 3- to 6-fold elevations on SGPT (ALT) in a few patients.", "output": "<trazodone hydrochloride, effect, buspirone HCl>, <Desyrel, effect, buspirone HCl>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a study in normal volunteers, concomitant administration of buspirone HCl and haloperidol resulted in increased serum haloperidol concentrations.", "output": "<buspirone HCl, mechanism, haloperidol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, there has been one report of prolonged prothrombin time when buspirone was added to the regimen of a patient treated with warfarin.", "output": "<buspirone, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In vitro, buspirone may displace less firmly bound drugs like digoxin.", "output": "<buspirone, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of L-phenylalanine and non-selective MAO inhibitors may cause hypertension.", "output": "<L-phenylalanine, effect, non-selective MAO inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Selegiline - L-phenylalanine and the selective MAO inhibitor selegiline may have synergistic antidepressant activity if used concomitantly.", "output": "<L-phenylalanine, effect, selegiline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Neuroleptic Drugs - L-phenylalanine may potentiate the tardive dyskinesia side reactions of neuroleptic drugs if used concomitantly with them.", "output": "<Neuroleptic Drugs, effect, L-phenylalanine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nabilone should be administered with caution to patients who are taking other psychoactive drugs or CNS depressants, including alcohol, barbiturates and narcotic analgesics, or to those with a history of psychiatric disorder (including manic-depressive illness and schizophrenia).", "output": "<Nabilone, advise, psychoactive drugs>, <Nabilone, advise, CNS depressants>, <Nabilone, advise, alcohol>, <Nabilone, advise, barbiturates>, <Nabilone, advise, narcotic analgesics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nabilone has been shown to have an additive CNS depressant effect when given with either diazepam, secobarbitone sodium, alcohol or codeine.", "output": "<Nabilone, effect, diazepam>, <Nabilone, effect, secobarbitone sodium>, <Nabilone, effect, alcohol>, <Nabilone, effect, codeine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin, Digoxin, Salicylate, and Heparin The in vitro binding of warfarin to plasma proteins is only slightly reduced by ketorolac tromethamine (99.5% control vs 99.3%) when ketorolac plasma concentrations reach 5 to10 m g/mL.", "output": "<warfarin, mechanism, ketorolac tromethamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In vitro studies indicate that, at therapeutic concentrations of salicylate (300 m g/mL), the binding of ketorolac was reduced from approximately 99.2% to 97.5%, representing a potential twofold increase in unbound ketorolac plasma levels.", "output": "<salicylate, mechanism, ketorolac>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although these results do not indicate a significant interaction between TORADOL and warfarin or heparin, the administration of TORADOL to patients taking anticoagulants should be done extremely cautiously, and patients should be closely monitored.", "output": "<TORADOL, advise, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide: TORADOL IV/IM reduced the diuretic response to furosemide in normovolemic healthy subjects by approximately 20% (mean sodium and urinary output decreased 17%).", "output": "<TORADOL, effect, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid: Concomitant administration of TORADOL ORAL and probenecid resulted in decreased clearance of ketorolac and significant increases in ketorolac plasma levels (total AUC increased approximately threefold from 5.4 to 17.8 m g/h/mL) and terminal half-life increased approximately twofold from 6.6 to 15.1 hours.", "output": "<TORADOL, mechanism, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, concomitant use of TORADOL and probenecid is contraindicated.", "output": "<TORADOL, advise, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The effect of TORADOL on plasma lithium has not been studied, but cases of increased lithium plasma levels during TORADOL therapy have been reported.", "output": "<lithium, mechanism, TORADOL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methotrexate: Concomitant administration of methotrexate and some NSAIDs has been reported to reduce the clearance of methotrexate, enhancing the toxicity of methotrexate.", "output": "<methotrexate, mechanism, NSAIDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antiepileptic Drugs: Sporadic cases of seizures have been reported during concomitant use of TORADOL and antiepileptic drugs (phenytoin, carbamazepine).", "output": "<TORADOL, effect, antiepileptic drugs>, <TORADOL, effect, phenytoin>, <TORADOL, effect, carbamazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Psychoactive Drugs: Hallucinations have been reported when TORADOL was used in patients taking psychoactive drugs (fluoxetine, thiothixene, alprazolam).", "output": "<TORADOL, effect, psychoactive drugs>, <TORADOL, effect, fluoxetine>, <TORADOL, effect, thiothixene>, <TORADOL, effect, alprazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ethoxzolamide may increase the action of tricyclics, amphetamines, procainamide, and quinidine.", "output": "<Ethoxzolamide, effect, tricyclics>, <Ethoxzolamide, effect, amphetamines>, <Ethoxzolamide, effect, procainamide>, <Ethoxzolamide, effect, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of ethoxzolamide with other diuretics, amphotericin B, and corticosteroids may cause hypokalemia.", "output": "<ethoxzolamide, effect, diuretics>, <ethoxzolamide, effect, amphotericin B>, <ethoxzolamide, effect, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with ACE inhibitors, and with some angiotensin II receptor antagonists.", "output": "<lithium, mechanism, ACE inhibitors>, <lithium, mechanism, angiotensin II receptor antagonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "An increase in serum lithium concentration has been reported during concomitant administration of lithium with ATACAND, so careful monitoring of serum lithium levels is recommended during concomitant use.", "output": "<lithium, mechanism, ATACAND>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Repeated doses of colestipol hydrochloride given prior to a single dose of propranolol in human trials have been reported to decrease propranolol absorption.", "output": "<colestipol hydrochloride, mechanism, propranolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, patients on propranolol should be observed when COLESTID Tablets are either added or deleted from a therapeutic regimen.", "output": "<propranolol, advise, COLESTID>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Studies in humans show that the absorption of chlorothiazide as reflected in urinary excretion is markedly decreased even when administered one hour before colestipol hydrochloride.", "output": "<chlorothiazide, mechanism, colestipol hydrochloride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride;", "output": "<tetracycline, mechanism, colestipol hydrochloride>, <furosemide, mechanism, colestipol hydrochloride>, <penicillin G, mechanism, colestipol hydrochloride>, <hydrochlorothiazide, mechanism, colestipol hydrochloride>, <gemfibrozil, mechanism, colestipol hydrochloride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Particular caution should be observed with digitalis preparations since there are conflicting results for the effect of colestipol hydrochloride on the availability of digoxin and digitoxin.", "output": "<digitalis preparations, effect, colestipol hydrochloride>, <colestipol hydrochloride, mechanism, digoxin>, <colestipol hydrochloride, mechanism, digitoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Bile acid binding resins may also interfere with the absorption of oral phosphate supplements and hydrocortisone.", "output": "<Bile acid binding resins, mechanism, phosphate>, <Bile acid binding resins, mechanism, hydrocortisone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Benzthiazide may interact with alcohol, blood thinners, decongestant drugs (allergy, cold, and sinus medicines), diabetic drugs, lithium, norepinephrine, NSAIDs like Aleve or Ibuprofen, and high blood pressure medications.", "output": "<Benzthiazide, int, alcohol>, <Benzthiazide, int, blood thinner>, <Benzthiazide, int, decongestant drugs>, <Benzthiazide, int, lithium>, <Benzthiazide, int, norepinephrine>, <Benzthiazide, int, NSAIDs>, <Benzthiazide, int, Aleve>, <Benzthiazide, int, Ibuprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The risk of using bromocriptine mesylate in combination with other drugs has not been systematically evaluated, but alcohol may potentiate the side effects of bromocriptine mesylate.", "output": "<alcohol, effect, bromocriptine mesylate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Bromocriptine mesylate may interact with dopamine antagonists, butyrophenones, and certain other agents.", "output": "<Bromocriptine mesylate, int, dopamine antagonists>, <Bromocriptine mesylate, int, butyrophenones>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Compounds in these categories result in a decreased efficacy of bromocriptine mesylate: phenothiazines, haloperidol, metoclopramide, pimozide.", "output": "<bromocriptine mesylate, effect, phenothiazines>, <bromocriptine mesylate, effect, haloperidol>, <bromocriptine mesylate, effect, metoclopramide>, <bromocriptine mesylate, effect, pimozide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of bromocriptine mesylate with other ergot alkaloids is not recommended.", "output": "<bromocriptine mesylate, advise, ergot alkaloids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, linezolid has the potential for interaction with adrenergic and serotonergic agents.", "output": "<linezolid, int, adrenergic>, <linezolid, int, serotonergic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Adrenergic Agents:Some individuals receiving ZYVOX may experience a reversible enhancement of the pressor response to indirect-acting sympathomimetic agents, vasopressor or dopaminergic agents.", "output": "<ZYVOX, effect, sympathomimetic agents>, <ZYVOX, effect, vasopressor>, <ZYVOX, effect, dopaminergic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Spontaneous reports of serotonin syndrome associated with co-administration of ZYVOX and serotonergic agents, including antidepressants such as selective serotonin reuptake inhibitors (SSRIs), have been reported.", "output": "<ZYVOX, effect, serotonergic agents>, <ZYVOX, effect, antidepressants>, <ZYVOX, effect, selective serotonin reuptake inhibitors>, <ZYVOX, effect, SSRIs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients who are treated with ZYVOX and concomitant serotonergic agents should be closely observed for signs and symptoms of serotonin syndrome (e.g., cognitive dysfunction, hyperpyrexia, hyperreflexia, incoordination).", "output": "<ZYVOX, effect, serotonergic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If any signs or symptoms occur physicians should consider discontinuation of either one or both agents (ZYVOX or concomitant serotonergic agents).", "output": "<ZYVOX, advise, serotonergic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coumarin Anticoagulants Altered coagulation parameters and/or bleeding have been reported in patients taking capecitabine concomitantly with coumarin-derivative anticoagulants such as warfarin and phenprocoumon.", "output": "<capecitabine, effect, coumarin-derivative anticoagulants>, <capecitabine, effect, phenprocoumon>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients taking coumarin-derivative anticoagulants concomitantly with capecitabine should be monitored regularly for alterations in their coagulation parameters (PT or INR).", "output": "<coumarin-derivative anticoagulants, advise, capecitabine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Leucovorin: The concentration of 5-fluorouracil is increased and its toxicity may be enhanced by leucovorin.", "output": "<5-fluorouracil, mechanism, leucovorin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Deaths from severe enterocolitis, diarrhea, and dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil.", "output": "<leucovorin, effect, fluorouracil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The rate of metabolism and the leukopenic activity of cyclophosphamide reportedly are increased by chronic administration of high doses of phenobarbital.", "output": "<cyclophosphamide, mechanism, phenobarbital>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclophosphamide treatment, which causes a marked and persistent inhibition of cholinesterase activity, potentiates the effect of succinylcholine chloride.", "output": "<Cyclophosphamide, effect, succinylcholine chloride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Iodine or iodine excess may decrease the effect of Carbimazole, and an iodine deficiency can increase the effect of Carbimazole.", "output": "<Iodine, effect, Carbimazole>, <iodine, effect, Carbimazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Serum concentration of digoxin and digitoxin may increase when patients take antithyroid agents.", "output": "<digoxin, mechanism, antithyroid agents>, <digitoxin, mechanism, antithyroid agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antithyroid agents may decrease thyroidal uptake of sodium iodide I131, a rebound in uptake may occur up to 5 days after sudden withdrawal of Carbimazole.", "output": "<Antithyroid agents, effect, sodium iodide I131>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Based on anecdotal reports, there may be an interaction between buprenorphine and benzodiazepines.", "output": "<buprenorphine, int, benzodiazepines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been a number of reports in the post-marketing experience of coma and death associated with the concomitant intravenous misuse of buprenorphine and benzodiazepines by addicts.", "output": "<buprenorphine, effect, benzodiazepines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "SUBUTEX and SUBOXONE should be prescribed with caution to patients on benzodiazepines or other drugs that act on the central nervous system, regardless of whether these drugs are taken on the advice of a physician or are taken as drugs of abuse.", "output": "<SUBUTEX, advise, benzodiazepines>, <SUBOXONE, advise, benzodiazepines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients should be warned of the potential danger of the intravenous self-administration of benzodiazepines while under treatment with SUBOXONE or SUBUTEX.", "output": "<benzodiazepines, advise, SUBOXONE>, <benzodiazepines, advise, SUBUTEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Blood levels of hydrodolasetron increased 24% when dolasetron was coadministered with cimetidine (nonselective inhibitor of cytochrome P-450) for 7 days, and decreased 28% with coadministration of rifampin (potent inducer of cytochrome P-450) for 7 days.", "output": "<dolasetron, mechanism, cimetidine>, <dolasetron, mechanism, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Clearance of hydrodolasetron decreased by about 27% when dolasetron mesylate was administered intravenously concomitantly with atenolol.", "output": "<dolasetron mesylate, mechanism, atenolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chlorprothixene may increase the plasma-level of concomitantly given lithium.", "output": "<Chlorprothixene, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If chlorprothixene is given concomitantly with opioids, the opioid dose should be reduced (by approx. 50%), because chlorprothixene amplifies the therapeutic actions and side-effects of opioids massively.", "output": "<chlorprothixene, advise, opioids>, <chlorprothixene, effect, opioids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Avoid the concomitant use of chlorprothixene and tramadol (Ultram).", "output": "<chlorprothixene, advise, tramadol>, <chlorprothixene, advise, Ultram>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Consider additive sedative effects and confusional states to emerge, if chlorprothixene is given with benzodiazepines or barbituates.", "output": "<chlorprothixene, effect, benzodiazepines>, <chlorprothixene, effect, barbituates>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Exert particular caution in combining chlorprothixene with other anticholinergic drugs (tricyclic antidepressants and antiparkinsonian agents): Particularly the elderly may develop delirium, high fever, severe obstipation, even ileus and glaucoma.", "output": "<chlorprothixene, advise, anticholinergic drugs>, <chlorprothixene, advise, tricyclic antidepressants>, <chlorprothixene, advise, antiparkinsonian agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Use in Conjunction with Other Antiepileptic Drugs: The addition of Felbatol  to antiepileptic drugs (AEDs) affects the steady-state plasma concentrations of AEDs.", "output": "<Felbatol, mechanism, antiepileptic drugs>, <Felbatol, mechanism, AEDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Specific Effects of Felbatol  on Other Antiepileptic Drugs Phenytoin: Felbatol  causes an increase in steady-state phenytoin plasma concentrations.", "output": "<Felbatol, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Increasing the felbamate dose to 1800 mg/day in six of these subjects increased the steady-state phenytoin Cmin to 25 7 micrograms/mL.", "output": "<felbamate, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In order to maintain phenytoin levels, limit adverse experiences, and achieve the felbamate dose of 3600 mg/day, a phenytoin dose reduction of approximately 40% was necessary for eight of these 10 subjects.", "output": "<felbamate, advise, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Carbamazepine: Felbatol  causes a decrease in the steady-state carbamazepine plasma concentrations and an increase in the steady-state carbamazepine epoxide plasma concentration.", "output": "<Felbatol, mechanism, carbamazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The carbamazepine steady-state Cmin decreased 31% to 5 1 micrograms/mL when felbamate (3000 mg/day, divided into three doses) was coadministered.", "output": "<carbamazepine, mechanism, felbamate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Valproate: Felbatol  causes an increase in steady-state valproate concentrations.", "output": "<Felbatol, mechanism, valproate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Increasing the felbamate dose to 2400 mg/day increased the steadystate valproate Cmin to 96 25 micrograms/mL.", "output": "<felbamate, mechanism, valproate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenobarbital: Coadministration of felbamate with phenobarbital causes an increase in phenobarbital plasma concentrations, In 12 otherwise healthy male volunteers ingesting phenobarbital, the steady-state trough (Cmin) phenobarbital concentration was 14.2 micrograms/mL.", "output": "<felbamate, mechanism, phenobarbital>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Effects of Other Antiepileptic Drugs on Felbatol  Phenytoin: Phenytoin causes an approximate doubling of the clearance of Felbatol  (felbamate) at steady state and, therefore, the addition of phenytoin causes an approximate 45% decrease in the steady-state trough concentrations of Felbatol  as compared to the same dose of Felbatol  given as monotherapy.", "output": "<Phenytoin, mechanism, Felbatol>, <Phenytoin, mechanism, felbamate>, <phenytoin, mechanism, Felbatol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Carbamazepine: Carbamazepine causes an approximate 50% increase in the clearance of Felbatol  at steady state and, therefore, the addition of carbamazepine results in an approximate 40% decrease in the steady-state trough concentrations of Felbatol  as compared to the same dose of Felbatol  given as monotherapy.", "output": "<Carbamazepine, mechanism, Felbatol>, <carbamazepine, mechanism, Felbatol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenobarbital: It appears that phenobarbital may reduce plasma felbamate concentrations.", "output": "<phenobarbital, mechanism, felbamate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Felbamate treatment resulted in a 42% decrease in the gestodene AUC 0-24, but no clinically relevant effect was observed on the pharmacokinetic parameters of ethinyl estradiol.", "output": "<Felbamate, mechanism, gestodene>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chirocaine   should be used with caution in patients receiving other local anesthetics or agents structurally related to amide-type local anesthetics since the toxic effects of these drugs could be additive.", "output": "<Chirocaine, advise, anesthetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although no clinical studies have been conducted, it is likely that the metabolism of levobupivacaine may be affected by the known CYP3A4 inducers (such as phenytoin, phenobarbital, rifampin), CYP3A4 inhibitors (azole antimycotics e.g., ketoconazole;", "output": "<levobupivacaine, mechanism, phenytoin>, <levobupivacaine, mechanism, phenobarbital>, <levobupivacaine, mechanism, rifampin>, <levobupivacaine, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin.", "output": "<aspirin, mechanism, ketoprofen>, <aspirin, mechanism, ketoprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, concurrent use of aspirin and ketoprofen is not recommended.", "output": "<aspirin, advise, ketoprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone.", "output": "<Hydrochlorothiazide, effect, ketoprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs.", "output": "<ketoprofen, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding.", "output": "<Probenecid, mechanism, ketoprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, the combination of ketoprofen and probenecid is not recommended.", "output": "<ketoprofen, advise, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity.", "output": "<Ketoprofen, mechanism, methotrexate>, <NSAIDs, mechanism, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels.", "output": "<Nonsteroidal anti-inflammatory agents, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium.", "output": "<ketoprofen, advise, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Interactions for Vitamin B3 (Niacin): Antihypertensive Therapy: Nicotinic acid may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension.", "output": "<Nicotinic acid, effect, ganglionic blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: Concomitant aspirin may decrease the metabolic clearance of nicotinic acid.", "output": "<aspirin, mechanism, nicotinic acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of irbesartan reduced aliskiren Cmax up to 50% after multiple dosing.", "output": "<irbesartan, mechanism, aliskiren>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of atorvastatin resulted in about a 50% increase in aliskiren Cmax and AUC after multiple dosing.", "output": "<atorvastatin, mechanism, aliskiren>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: Co-administration of 200 mg twice-daily ketoconazole with aliskiren resulted in an approximate 80% increase in plasma levels of aliskiren.", "output": "<ketoconazole, mechanism, aliskiren>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide: When aliskiren was co-administered with furosemide, the AUC and Cmax of furosemide were reduced by about 30% and 50%, respectively.", "output": "<aliskiren, mechanism, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetaminophen: May increase plasma concentration of synthetic estrogens, possibly by inhibiting conjugation.", "output": "<Acetaminophen, mechanism, synthetic estrogens>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Combination hormonal contraceptives may also decrease the plasma concentration of acetaminophen.", "output": "<hormonal contraceptives, mechanism, acetaminophen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acitretin: Interferes with the contraceptive effect of microdosed progestin-containing minipill preparations.", "output": "<Acitretin, effect, progestin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aminoglutethimide: May increase CYP metabolism of progestins leading to possible decrease in contraceptive effectiveness.", "output": "<Aminoglutethimide, mechanism, progestins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticoagulants: Combination hormonal contraceptives may increase or decrease the effects of coumarin derivatives.", "output": "<hormonal contraceptives, effect, coumarin derivatives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticonvulsants (carbamazepine, felbamate, phenobarbital, phenytoin, topiramate): Increase the metabolism of ethinyl estradiol and/or some progestins, leading to possible decrease in contraceptive effectiveness.", "output": "<Anticonvulsants, mechanism, ethinyl estradiol>, <Anticonvulsants, mechanism, progestins>, <carbamazepine, mechanism, ethinyl estradiol>, <carbamazepine, mechanism, progestins>, <felbamate, mechanism, ethinyl estradiol>, <felbamate, mechanism, progestins>, <phenobarbital, mechanism, ethinyl estradiol>, <phenobarbital, mechanism, progestins>, <phenytoin, mechanism, ethinyl estradiol>, <phenytoin, mechanism, progestins>, <topiramate, mechanism, ethinyl estradiol>, <topiramate, mechanism, progestins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ascorbic acid: Doses of ascorbic acid (vitamin C) 1 g/day have been reported to increase plasma concentration of synthetic estrogens by ~47%, possibly by inhibiting conjugation;", "output": "<ascorbic acid, mechanism, synthetic estrogens>, <vitamin C, mechanism, synthetic estrogens>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Atorvastatin: Atorvastatin increases the AUC for norethindrone and ethinyl estradiol.", "output": "<Atorvastatin, mechanism, norethindrone>, <Atorvastatin, mechanism, ethinyl estradiol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Benzodiazepines: Combination hormonal contraceptives may decrease the clearance of some benzodiazepines (alprazolam, chlordiazepoxide, diazepam) and increase the clearance of others (lorazepam, oxazepam, temazepam).", "output": "<hormonal contraceptives, mechanism, benzodiazepines>, <hormonal contraceptives, mechanism, alprazolam>, <hormonal contraceptives, mechanism, chlordiazepoxide>, <hormonal contraceptives, mechanism, diazepam>, <hormonal contraceptives, mechanism, lorazepam>, <hormonal contraceptives, mechanism, oxazepam>, <hormonal contraceptives, mechanism, temazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Clofibric acid: Combination hormonal contraceptives may increase the clearance of clofibric acid.", "output": "<hormonal contraceptives, mechanism, clofibric acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporine: Combination hormonal contraceptives may inhibit the metabolism of cyclosporine, leading to increased plasma concentrations;", "output": "<hormonal contraceptives, mechanism, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Griseofulvin: Griseofulvin may induce the metabolism of combination hormonal contraceptives causing menstrual changes;", "output": "<Griseofulvin, mechanism, combination hormonal contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Morphine: Combination hormonal contraceptives may increase the clearance of morphine.", "output": "<hormonal contraceptives, mechanism, morphine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Non-nucleoside reverse transcriptase inhibitors (NNRTIs): Nevirapine may decrease plasma levels of combination hormonal contraceptives;", "output": "<Nevirapine, mechanism, combination hormonal contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Prednisolone: Ethinyl estradiol may inhibit the metabolism of prednisolone, leading to increased plasma concentrations.", "output": "<Ethinyl estradiol, mechanism, prednisolone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Protease inhibitors: Amprenavir, lopinavir, nelfinavir, and ritonavir have been shown to decrease plasma levels of combination hormonal contraceptives;", "output": "<Amprenavir, mechanism, combination hormonal contraceptives>, <lopinavir, mechanism, combination hormonal contraceptives>, <nelfinavir, mechanism, combination hormonal contraceptives>, <ritonavir, mechanism, combination hormonal contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Indinavir has been shown to increase plasma levels of combination hormonal contraceptives.", "output": "<Indinavir, mechanism, combination hormonal contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rifampin: Rifampin increases the metabolism of ethinyl estradiol and some progestins (norethindrone) resulting in decreased contraceptive effectiveness and increased menstrual irregularities.", "output": "<Rifampin, mechanism, ethinyl estradiol>, <Rifampin, mechanism, progestins>, <Rifampin, mechanism, norethindrone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Salicylic acid: Combination hormonal contraceptives may increase the clearance of salicylic acid.", "output": "<hormonal contraceptives, mechanism, salicylic acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Selegiline: Combination hormonal contraceptives may increase the serum concentration of selegiline.", "output": "<Combination hormonal contraceptives, mechanism, selegiline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Theophylline: Ethinyl estradiol may inhibit the metabolism of theophylline, leading to increased plasma concentrations.", "output": "<Ethinyl estradiol, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tricyclic antidepressants (amitriptyline, imipramine, nortriptyline): Metabolism may be inhibited by combination hormonal contraceptives, increasing plasma levels of antidepressant;", "output": "<Tricyclic antidepressants, mechanism, combination hormonal contraceptives>, <amitriptyline, mechanism, combination hormonal contraceptives>, <imipramine, mechanism, combination hormonal contraceptives>, <nortriptyline, mechanism, combination hormonal contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ETHANOL / NUTRITION / HERB INTERACTIONS: Food: CNS effects of caffeine may be enhanced if combination hormonal contraceptives are used concurrently with caffeine.", "output": "<combination hormonal contraceptives, effect, caffeine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The response to Factrel may be blunted by phenothiazines and dopamine antagonists which cause a rise in prolactin.", "output": "<Factrel, effect, phenothiazines>, <Factrel, effect, dopamine antagonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diuretics: Patients on diuretics, especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with Lotensin.", "output": "<diuretics, effect, Lotensin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The possibility of hypotensive effects with Lotensin can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with Lotensin.", "output": "<diuretic, advise, Lotensin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Potassium Supplements and Potassium-Sparing Diuretics Lotensin can attenuate potassium loss caused by thiazide diuretics.", "output": "<Potassium-Sparing Diuretics, effect, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium.", "output": "<ACE inhibitors, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If a diuretic is also used, the risk of lithium toxicity may be increased.", "output": "<diuretic, effect, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Benazepril, like other ACE inhibitors, has had less than additive effects with beta-adrenergic blockers, presumably because both drugs lower blood pressure by inhibiting parts of the renin-angiotensin system", "output": "<Benazepril, effect, beta-adrenergic blockers>, <ACE inhibitors, effect, beta-adrenergic blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Geocillin (carbenicillin indanyl sodium) blood levels may be increased and prolonged by concurrent administration of probenecid.", "output": "<Geocillin, mechanism, probenecid>, <carbenicillin indanyl sodium, mechanism, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The hypoglycemic action of sulfonylurea may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents.", "output": "<sulfonylurea, effect, nonsteroidal anti-inflammatory agents>, <sulfonylurea, effect, salicylates>, <sulfonylurea, effect, sulfonamides>, <sulfonylurea, effect, chloramphenicol>, <sulfonylurea, effect, probenecid>, <sulfonylurea, effect, coumarins>, <sulfonylurea, effect, monoamine oxidase inhibitors>, <sulfonylurea, effect, beta adrenergic blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since animal studies suggest that the action of barbiturates may be prolonged by therapy with chlorpropamide, barbiturates should be employed with caution.", "output": "<barbiturates, effect, chlorpropamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported.", "output": "<miconazole, effect, hypoglycemic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: Concomitant administration of aspirin with valdecoxib may result in an increased risk of GI ulceration and complications compared to valdecoxib alone.", "output": "<aspirin, effect, valdecoxib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ACE-inhibitors:Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors.", "output": "<NSAIDs, effect, ACE-inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This interaction should be given consideration in patients taking BEXTRA concomitantly with ACE-inhibitors.", "output": "<BEXTRA, advise, ACE-inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide: Clinical studies, as well as post-marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.", "output": "<NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticonvulsants (Phenytoin): Steady state plasma exposure (AUC) of valdecoxib (40 mg BID for 12 days) was decreased by 27% when co-administered with multiple doses (300 mg QD for 12 days) of phenytoin (a CYP 3A4 inducer).", "output": "<valdecoxib, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients already stabilized on valdecoxib should be closely monitored for loss of symptom control with phenytoin coadministration.", "output": "<valdecoxib, advise, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration with valdecoxib (40 mg BID for 7 days) resulted in a significant increase in dextromethorphan plasma levels suggesting that, at these doses, valdecoxib is a weak inhibitor of 2D6.", "output": "<valdecoxib, mechanism, dextromethorphan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Even so dextromethorphan plasma concentrations in the presence of high doses of valdecoxib were almost 5-fold lower than those seen in CYP 2D6 poor metabolizers suggesting that dose adjustment is not necessary.", "output": "<dextromethorphan, mechanism, valdecoxib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: Valdecoxib 40 mg BID for 7 days produced significant decreases in lithium serum clearance (25%) and renal clearance (30%) with a 34% higher serum exposure compared to lithium alone.", "output": "<Valdecoxib, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium serum concentrations should be monitored closely when initiating or changing therapy with BEXTRA in patients receiving lithium.", "output": "<BEXTRA, advise, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Valdecoxib caused a statistically significant increase in plasma exposures of R-warfarin and S-warfarin (12% and 15%, respectively), and in the pharmacodynamic effects (prothrombin time, measured as INR) of warfarin.", "output": "<Valdecoxib, mechanism, R-warfarin>, <Valdecoxib, mechanism, S-warfarin>, <Valdecoxib, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticoagulant therapy should be monitored, particularly during the first few weeks, after initiating therapy with BEXTRA in patients receiving warfarin or similar agents.", "output": "<BEXTRA, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant single dose administration of valdecoxib 20 mg with multiple doses of ketoconazole and fluconazole produced a significant increase in exposure of valdecoxib.", "output": "<valdecoxib, mechanism, ketoconazole>, <valdecoxib, mechanism, fluconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Plasma exposure (AUC) to valdecoxib was increased 62% when coadministered with fluconazole and 38% when coadministered with ketoconazole.", "output": "<valdecoxib, mechanism, fluconazole>, <valdecoxib, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of valdecoxib (40 mg BID (day 1) and 40 mg QD (days 2-7)) with glyburide (10 mg glyburide BID) resulted in 21% increase in glyburide AUC0-12 and a 16% increase in glyburide Cmax leading to a 16% decrease in glucose AUC0-24.", "output": "<valdecoxib, mechanism, glyburide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because changes in glucose concentrations with valdecoxib coadministration were within the normal variability and individual glucose concentrations were above or near 70 mg/dL, dose adjustment for glyburide (5 mg QD and 10 mg BID) with valdecoxib coadministration (up to 40 mg QD) is not indicated.", "output": "<glyburide, advise, valdecoxib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration with valdecoxib increased exposure of omeprazole (AUC) by 46%.", "output": "<valdecoxib, mechanism, omeprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of valdecoxib and Ortho-Novum 1/35  increased the exposure of norethindrone and ethinyl estradiol by 20% and 34%, respectively.", "output": "<valdecoxib, mechanism, Ortho-Novum>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "These increased exposures of norethindrone and ethinyl estradiol should be taken into consideration when selecting an oral contraceptive for women taking valdecoxib.", "output": "<contraceptive, advise, valdecoxib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Plasma exposure of diazepam (10 mg BID) was increased by 28% following administration of valdecoxib (40 mg BID) for 12 days, while plasma exposure of valdecoxib (40 mg BID) was not substantially increased following administration of diazepam (10 mg BID) for 12 days.", "output": "<diazepam, mechanism, valdecoxib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although the magnitude of changes in diazepam plasma exposure when coadministered with valdecoxib were not sufficient to warrant dosage adjustments, patients may experience enhanced sedative side effects caused by increased exposure of diazepam under this circumstance.", "output": "<valdecoxib, effect, diazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Given the primary CNS effects of Clozapine, caution is advised in using it concomitantly with other CNS-active drugs or alcohol.", "output": "<Clozapine, effect, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although it has not been established that there is an interaction between Clozapine and benzodiazepines or other psychotropics, caution is advised when clozapine is initiated in patients taking a benzodiazepine or any other psychotropic drug.", "output": "<clozapine, advise, benzodiazepine>, <clozapine, advise, psychotropic drug>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Clozapine may potentiate the hypotensive effects of antihypertensive drugs and the anticholinergic effects of atropine-type drugs.", "output": "<Clozapine, effect, antihypertensive drugs>, <Clozapine, effect, atropine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin, nicotine, and rifampin may decrease Clozapine plasma levels, resulting in a decrease in effectiveness of a previously effective Clozapine dose.", "output": "<Phenytoin, mechanism, Clozapine>, <nicotine, mechanism, Clozapine>, <rifampin, mechanism, Clozapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine, caffeine, and erythromycin may increase plasma levels of Clozapine, potentially resulting in adverse effects.", "output": "<Cimetidine, mechanism, Clozapine>, <caffeine, mechanism, Clozapine>, <erythromycin, mechanism, Clozapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although concomitant use of Clozapine and carbamazepine is not recommended, it should be noted that discontinuation of concomitant carbamazepine administration may result in an increase in Clozapine plasma levels.", "output": "<Clozapine, advise, carbamazepine>, <carbamazepine, mechanism, Clozapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Paroxetine produced only minor changes in the levels of clozapine and its metabolites.", "output": "<Paroxetine, mechanism, clozapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, other published reports describe modest elevations (less than two-fold) of clozapine and metabolite concentrations when clozapine was taken with paroxetine, fluoxetine, and sertraline.", "output": "<clozapine, mechanism, paroxetine>, <clozapine, mechanism, fluoxetine>, <clozapine, mechanism, sertraline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, such combined treatment should be approached with caution and patients should be monitored closely when Clozapine is combined with these drugs, particularly with fluvoxamine.", "output": "<Clozapine, advise, fluvoxamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, co-administration of clozapine with other drugs that are metabolized by this isozyme, including antidepressants, phenothiazines, carbamazepine, and Type 1C antiarrhythmics (e.g., propafenone, flecainide and encainide), or that inhibit this enzyme (e.g., quinidine), should be approached with caution.", "output": "<clozapine, advise, antidepressants>, <clozapine, advise, phenothiazines>, <clozapine, advise, carbamazepine>, <clozapine, advise, Type 1C antiarrhythmics>, <clozapine, advise, propafenone>, <clozapine, advise, flecainide>, <clozapine, advise, encainide>, <clozapine, advise, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Some quinolones, including ciprofloxacin, have also been shown to interfere with the metabolism of caffeine.", "output": "<quinolones, mechanism, caffeine>, <ciprofloxacin, mechanism, caffeine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Some quinolones, including ciprofloxacin, have been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.", "output": "<quinolones, effect, cyclosporine>, <ciprofloxacin, effect, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Glyburide: The concomitant administration of ciprofloxacin with the sulfonylurea glyburide has, on rare occasions, resulted in severe hypoglycemia.", "output": "<ciprofloxacin, effect, sulfonylurea>, <ciprofloxacin, effect, glyburide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methotrexate Renal tubular transport of methotrexate may be inhibited by concomitant administration of ciprofloxacin, potentially leading to increased plasma levels of methotrexate.", "output": "<methotrexate, mechanism, ciprofloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, patients under methotrexate therapy should be carefully monitored when concomitant ciprofloxacin therapy is indicated.", "output": "<methotrexate, advise, ciprofloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Multivalent Cation-Containing Products: Concurrent administration of a quinolone, including ciprofloxacin, with multivalent cation-containing products such as magnesium or aluminum antacids, sucralfate, VIDEX chewable/buffered tablets or pediatric powder, or products containing calcium, iron, or zinc may substantially decrease the absorption of ciprofloxacin, resulting in serum and urine levels considerably lower than desired.", "output": "<quinolone, mechanism, magnesium>, <quinolone, mechanism, aluminum>, <quinolone, mechanism, antacids>, <quinolone, mechanism, sucralfate>, <quinolone, mechanism, VIDEX>, <quinolone, mechanism, calcium>, <quinolone, mechanism, iron>, <quinolone, mechanism, zinc>, <ciprofloxacin, mechanism, magnesium>, <ciprofloxacin, mechanism, aluminum>, <ciprofloxacin, mechanism, antacids>, <ciprofloxacin, mechanism, sucralfate>, <ciprofloxacin, mechanism, VIDEX>, <ciprofloxacin, mechanism, calcium>, <ciprofloxacin, mechanism, iron>, <ciprofloxacin, mechanism, zinc>, <ciprofloxacin, mechanism, ciprofloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This time window is different than for other oral formulations of ciprofloxacin, which are usually administered 2 hours before or 6 hours after antacids.", "output": "<ciprofloxacin, advise, antacids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin: Altered serum levels of phenytoin (increased and decreased) have been reported in patients receiving concomitant ciprofloxacin.", "output": "<phenytoin, mechanism, ciprofloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid: Probenecid interferes with renal tubular secretion of ciprofloxacin and produces an increase in the level of ciprofloxacin in serum.", "output": "<Probenecid, mechanism, ciprofloxacin>, <Probenecid, mechanism, ciprofloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Theophylline: As with some other quinolones, concurrent administration of ciprofloxacin with theophylline may lead to elevated serum concentrations of theophylline and prolongation of its elimination half-life.", "output": "<quinolones, mechanism, theophylline>, <ciprofloxacin, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin: Quinolones have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives.", "output": "<Quinolones, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Bismuth: Bismuth subsalicylate, given concomitantly with enoxacin or 60 minutes following enoxacin administration, decreased enoxacin bioavailability by approximately 25%.", "output": "<Bismuth subsalicylate, mechanism, enoxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus, concomitant administration of enoxacin and bismuth subsalicylate should be avoided.", "output": "<enoxacin, advise, bismuth subsalicylate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caffeine: Enoxacin is a potent inhibitor of the cytochrome P-450 isozymes responsible for the metabolism of methylxanthines.", "output": "<Enoxacin, mechanism, methylxanthines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a multiple-dose study, enoxacin caused a dose-related increase in the mean elimination half-life of caffeine, thereby decreasing the clearance of caffeine by up to 80% and leading to a five-fold increase in the AUC and the half-life of caffeine.", "output": "<enoxacin, mechanism, caffeine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Trough plasma enoxacin levels were also 20% higher when caffeine and enoxacin were administered concomitantly.", "output": "<caffeine, mechanism, enoxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caffeine-related adverse effects have occurred in patients consuming caffeine while on therapy with enoxacin.", "output": "<caffeine, effect, enoxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporine: Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with other members of the quinolone class.", "output": "<cyclosporine, mechanism, quinolone class>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digoxin: Enoxacin may raise serum digoxin levels in some individuals.", "output": "<Enoxacin, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If signs and symptoms suggestive of digoxin toxicity occur when enoxacin and digoxin are given concomitantly, physicians are advised to obtain serum digoxin levels and adjust digoxin doses appropriately.", "output": "<enoxacin, effect, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Non-steroidal anti-inflammatory agents: Seizures have been reported in patients taking enoxacin concomitantly with the nonsteroidal anti-inflammatory drug fenbufen.", "output": "<enoxacin, effect, fenbufen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "or with multivitamins containing zinc may substantially interfere with drug absorption and result in insufficient plasma and tissue quinolone concentrations.", "output": "<zinc, mechanism, quinolone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids containing aluminum hydroxide and magnesium hydroxide reduce the oral absorption of enoxacin by 75%.", "output": "<aluminum hydroxide, mechanism, enoxacin>, <magnesium hydroxide, mechanism, enoxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The oral bioavailability of enoxacin is reduced by 60% with coadministration of ranitidine.", "output": "<enoxacin, mechanism, ranitidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Theophylline: Enoxacin is a potent inhibitor of the cytochrome P-450 isozymes responsible for the metabolism of methylxanthines.", "output": "<Enoxacin, mechanism, methylxanthines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Enoxacin interferes with the metabolism of theophylline resulting in a 42% to 74% dose-related decrease in theophylline clearance and a subsequent 260% to 350% increase in serum theophylline levels.", "output": "<Enoxacin, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Theophylline-related adverse effects have occurred in patients when theophylline and enoxacin were coadministered.", "output": "<theophylline, effect, enoxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin: Quinolones, including enoxacin, decrease the clearance of R-warfarin, the less active isomer of racemic warfarin.", "output": "<Quinolones, mechanism, R-warfarin>, <enoxacin, mechanism, R-warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nevertheless, the prothrombin time or other suitable coagulation test should be monitored when warfarin or its derivatives and enoxacin are given concomitantly.", "output": "<warfarin, advise, enoxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rifampin: Coadministration of rifampin and MEPRON Suspension results in a significant decrease in average steady- state plasma atovaquone concentrations.", "output": "<rifampin, mechanism, MEPRON>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Alternatives to rifampin should be considered during the course of PCP treatment with MEPRON.", "output": "<rifampin, advise, MEPRON>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Products containing calcium and other multivalent cations (such as aluminum, magnesium, iron) are likely to interfere with absorption of Ibandronate.", "output": "<calcium, mechanism, Ibandronate>, <aluminum, mechanism, Ibandronate>, <magnesium, mechanism, Ibandronate>, <iron, mechanism, Ibandronate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ibandronate should be taken at least 60 minutes before any oral medications containing multivalent cations (including antacids, supplements or vitamins).", "output": "<Ibandronate, advise, antacids>, <Ibandronate, advise, vitamins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, since aspirin, NSAIDs, and bisphosphonates are all associated with gastrointestinal irritation, caution should be exercised in the concomitant use of aspirin or NSAIDs with Ibandronate.", "output": "<aspirin, advise, Ibandronate>, <NSAIDs, advise, Ibandronate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Total body clearance of Simulect was reduced by an average 22% and 51% when azathioprine and mycophenolate mofetil, respectively, were added to a regimen consisting of cyclosporine, USP (MODIFIED) and corticosteroids.", "output": "<Simulect, mechanism, azathioprine>, <Simulect, mechanism, mycophenolate mofetil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The benzodiazepines, including alprazolam, produce additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol, and other drugs which themselves produce CNS depression.", "output": "<benzodiazepines, effect, psychotropic medications>, <benzodiazepines, effect, anticonvulsants>, <benzodiazepines, effect, antihistaminics>, <benzodiazepines, effect, ethanol>, <alprazolam, effect, psychotropic medications>, <alprazolam, effect, anticonvulsants>, <alprazolam, effect, antihistaminics>, <alprazolam, effect, ethanol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The steady state plasma concentrations of imipramine and desipramine have been reported to be increased an average of 31% and 20%, respectively, by the concomitant administration of alprazolam tablets in doses up to 4 mg/day.", "output": "<imipramine, mechanism, alprazolam>, <desipramine, mechanism, alprazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs Demonstrated to be CYP 3A Inhibitors of Possible Clinical Significance on the Basis of Clinical Studies Involving Alprazolam (caution is recommended during coadministration with alprazolam): Coadministration of fluoxetine with alprazolam increased the maximum plasma concentration of alprazolam by 46%, decreased clearance by 21%, increased half-life by 17%, and decreased measured psychomotor performance.", "output": "<fluoxetine, mechanism, alprazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of propoxyphene decreased the maximum plasma concentration of alprazolam by 6%, decreased clearance by 38%, and increased half-life by 58%.", "output": "<propoxyphene, mechanism, alprazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of oral contraceptives increased the maximum plasma concentration of alprazolam by 18%, decreased clearance by 22%, and increased half-life by 29%.", "output": "<contraceptives, mechanism, alprazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs and other substances demonstrated to be CYP 3A inhibitors on the basis of clinical studies involving benzodiazepines metabolized similarly to alprazolam or on the basis of in vitro studies with alprazolam or other benzodiazepines (caution is recommended during coadministration with alprazolam): Available data from clinical studies of benzodiazepines other than alprazolam suggest a possible drug interaction with alprazolam for the following: diltiazem, isoniazid, macrolide antibiotics such as erythromycin and clarithromycin, and grapefruit juice.", "output": "<alprazolam, int, diltiazem>, <alprazolam, int, isoniazid>, <alprazolam, int, macrolide antibiotics>, <alprazolam, int, erythromycin>, <alprazolam, int, clarithromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Data from in vitro studies of alprazolam suggest a possible drug interaction with alprazolam for the following: sertraline and paroxetine.", "output": "<alprazolam, int, sertraline>, <alprazolam, int, paroxetine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Data from in vitro studies of benzodiazepines other than alprazolam suggest a possible drug interaction for the following: ergotamine, cyclosporine, amiodarone, nicardipine, and nifedipine.", "output": "<benzodiazepines, int, ergotamine>, <benzodiazepines, int, cyclosporine>, <benzodiazepines, int, amiodarone>, <benzodiazepines, int, nicardipine>, <benzodiazepines, int, nifedipine>, <alprazolam, int, ergotamine>, <alprazolam, int, cyclosporine>, <alprazolam, int, amiodarone>, <alprazolam, int, nicardipine>, <alprazolam, int, nifedipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Interactions with Other CNS Agents: Concurrent use of Levo-Dromoran with all central nervous system depressants (eg, alcohol, sedatives, hypnotics, other opioids, general anesthetics, barbiturates, tricyclic antidepressants, phenothiazines, tranquilizers, skeletal muscle relaxants and antihistamines) may result in additive central nervous system depressant effects.", "output": "<Levo-Dromoran, effect, central nervous system depressants>, <Levo-Dromoran, effect, alcohol>, <Levo-Dromoran, effect, sedatives>, <Levo-Dromoran, effect, hypnotics>, <Levo-Dromoran, effect, opioids>, <Levo-Dromoran, effect, anesthetics>, <Levo-Dromoran, effect, barbiturates>, <Levo-Dromoran, effect, tricyclic antidepressants>, <Levo-Dromoran, effect, phenothiazines>, <Levo-Dromoran, effect, tranquilizers>, <Levo-Dromoran, effect, skeletal muscle relaxants>, <Levo-Dromoran, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although no interaction between MAO inhibitors and Levo-Dromoran has been observed, it is not recommended for use with MAO inhibitors.", "output": "<Levo-Dromoran, advise, MAO inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Interactions with Mixed Agonist/Antagonist Opioid Analgesics: Agonist/antagonist analgesics (eg, pentazocine, nalbuphine, butorphanol, dezocine and buprenorphine) should NOT be administered to a patient who has received or is receiving a course of therapy with a pure agonist opioid analgesic such as Levo-Dromoran.", "output": "<Agonist/antagonist analgesics, advise, Levo-Dromoran>, <pentazocine, advise, Levo-Dromoran>, <nalbuphine, advise, Levo-Dromoran>, <butorphanol, advise, Levo-Dromoran>, <dezocine, advise, Levo-Dromoran>, <buprenorphine, advise, Levo-Dromoran>, <pure agonist opioid analgesic, advise, Levo-Dromoran>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Amitriptyline: Concurrent administration of 25 mg or 100 mg cinacalcet with 50 mg amitriptyline increased amitriptyline exposure and nortriptyline (active metabolite) exposure by approximately 20% in CYP2D6 extensive metabolizers.", "output": "<cinacalcet, mechanism, amitriptyline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of ketoconazole, a strong inhibitor of CYP3A4, increased cinacalcet exposure following a single 90 mg dose of Sensipar by 2.3 fold.", "output": "<ketoconazole, mechanism, cinacalcet>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dose adjustment of Sensipar may be required and PTH and serum calcium concentrations should be closely monitored if a patient initiates or discontinues therapy with a strong CYP3A4 inhibitor (e.g., ketoconazole, erythromycin, itraconazole;", "output": "<Sensipar, advise, ketoconazole>, <Sensipar, advise, erythromycin>, <Sensipar, advise, itraconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-treatment with the potent CYP3A4 inhibitor ketoconazole increases erlotinib AUC by 2/3.", "output": "<ketoconazole, mechanism, erlotinib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be used when administering or taking TARCEVA with ketoconazole and other strong CYP3A4 inhibitors such as, but not limited to, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin (TAO), and voriconazole .", "output": "<TARCEVA, advise, ketoconazole>, <TARCEVA, advise, atazanavir>, <TARCEVA, advise, clarithromycin>, <TARCEVA, advise, indinavir>, <TARCEVA, advise, itraconazole>, <TARCEVA, advise, nefazodone>, <TARCEVA, advise, nelfinavir>, <TARCEVA, advise, ritonavir>, <TARCEVA, advise, saquinavir>, <TARCEVA, advise, telithromycin>, <TARCEVA, advise, troleandomycin>, <TARCEVA, advise, TAO>, <TARCEVA, advise, voriconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pre-treatment with the CYP3A4 inducer rifampicin decreased erlotinib AUC by about 2/3.", "output": "<rifampicin, mechanism, erlotinib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If the TARCEVA dose is adjusted upward, the dose will need to be reduced upon discontinuation of rifampicin or other inducers.", "output": "<TARCEVA, advise, rifampicin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other depressasnts such as alcohol, barbiturates, and MAOIs may enhance CNS depression when administered with ethchlorvynol.", "output": "<alcohol, effect, ethchlorvynol>, <barbiturates, effect, ethchlorvynol>, <MAOIs, effect, ethchlorvynol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In the first study, concomitant administration of 0.2 mg cerivastatin sodium and 12 g cholestyramine resulted in decreases of more than 22% for AUC and 40% for Cmax when compared to dosing cerivastatin sodium alone.", "output": "<cerivastatin sodium, mechanism, cholestyramine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, in the second study, administration of 12 g cholestyramine 1 hour before the evening meal and 0.3 mg cerivastatin sodium approximately 4 hours after the same evening meal resulted in a decrease in the cerivastatin AUC of less than 8%, and a decrease in Cmax of about 30% when compared to dosing cerivastatin sodium alone.", "output": "<cholestyramine, mechanism, cerivastatin sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ERYTHROMYCIN: In hypercholesterolemic patients, steady-state cerivastatin AUC and Cmax increased approximately 50% and 24% respectively after 10 days with co-administration of erythromycin, a known inhibitor of cytochrome P450 3A4.", "output": "<cerivastatin, mechanism, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Allopurinol: The AUC of didanosine was increased about 4-fold when allopurinol at 300 mg/day was coadministered with a single 200-mg dose of VIDEX to two patients with renal impairment (CLcr=15 and 18 mL/min).", "output": "<allopurinol, mechanism, VIDEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids: Concomitant administration of antacids containing magnesium or aluminum with VIDEX Chewable/Dispersible Buffered Tablets or Pediatric Powder for Oral Solution may potentiate adverse events associated with the antacid components.", "output": "<antacids, effect, VIDEX>, <magnesium, effect, VIDEX>, <aluminum, effect, VIDEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs Whose Absorption Can Be Affected by the Level of Acidity in the Stomach: Drugs such as ketoconazole and itraconazole should be administered at least 2 hours prior to dosing with VIDEX.", "output": "<ketoconazole, advise, VIDEX>, <itraconazole, advise, VIDEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ganciclovir: Administration of VIDEX 2 hours prior to or concurrent with oral ganciclovir was associated with a 111 (114)% increase in the steady-state AUC of didanosine (n = 12).", "output": "<VIDEX, mechanism, ganciclovir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A 21 (17)% decrease in the steady-state AUC of ganciclovir was observed when VIDEX was administered 2 hours prior to ganciclovir, but not when the two drugs were administered simultaneously (n = 12).", "output": "<VIDEX, mechanism, ganciclovir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Quinolone Antibiotics: VIDEX should be administered at least 2 hours after or 6 hours before dosing with ciprofloxacin because plasma concentrations of ciprofloxacin are decreased when administered with antacids containing magnesium, calcium, or aluminum.", "output": "<VIDEX, advise, ciprofloxacin>, <ciprofloxacin, mechanism, magnesium>, <ciprofloxacin, mechanism, calcium>, <ciprofloxacin, mechanism, aluminum>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In eight HIV-infected patients, the steady-state AUC of ciprofloxacin was decreased an average of 26% (95% CI = 14%, 37%) when ciprofloxacin was administered 2 hours prior to a marketed chewable/dispersible tablet formulation of VIDEX.", "output": "<ciprofloxacin, mechanism, VIDEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The AUC of ciprofloxacin was decreased an average of 15-fold in 12 healthy subjects given ciprofloxacin and didanosine-placebo tablets concurrently.", "output": "<ciprofloxacin, mechanism, didanosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a single subject given one dose of ciprofloxacin 2 hours after a dose of didanosine-placebo tablets, a greater than 50% reduction in the AUC of ciprofloxacin was observed.", "output": "<ciprofloxacin, mechanism, didanosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Plasma concentrations of quinolone antibiotics are decreased when administered with antacids containing magnesium, calcium, or aluminum.", "output": "<quinolone antibiotics, mechanism, magnesium>, <quinolone antibiotics, mechanism, calcium>, <quinolone antibiotics, mechanism, aluminum>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Interactions with Other Antiretroviral Drugs: Significant decreases in the AUC of delavirdine (20%) and indinavir (84%) occurred following simultaneous administration of these agents with VIDEX.", "output": "<delavirdine, mechanism, VIDEX>, <indinavir, mechanism, VIDEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "To avoid this interaction, delavirdine or indinavir should be given 1 hour prior to dosing with VIDEX.", "output": "<delavirdine, advise, VIDEX>, <indinavir, advise, VIDEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.", "output": "<SSRI, effect, TCA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nevertheless, caution is indicated in the coadministration of TCAs with any of the SSRIs and also in switching from one class to the other.", "output": "<TCAs, advise, SSRIs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hyperpyrexia has been reported when amitriptyline HCl is administered with anticholinergic agents or with neuroleptic drugs, particularly during hot weather.", "output": "<amitriptyline HCl, effect, anticholinergic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Paralytic ileus may occur in patients taking tricyclic antidepressants in combination with anticholinergic-type drugs.", "output": "<tricyclic antidepressants, effect, anticholinergic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine is reported to reduce hepatic metabolism of certain tricyclic antidepressants, thereby delaying elimination and increasing steady-state concentrations of these drugs.", "output": "<Cimetidine, mechanism, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Clinically significant effects have been reported with the tricyclic antidepressants when used concomitantly with cimetidine.", "output": "<tricyclic antidepressants, effect, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Increases in plasma levels of tricyclic antidepressants, and in the frequency and severity of side effects, particularly anticholinergic, have been reported when cimetidine was added to the drug regimen.", "output": "<tricyclic antidepressants, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Discontinuation of cimetidine in well-controlled patients receiving tricyclic antidepressants and cimetidine may decrease the plasma levels and efficacy of the antidepressants.", "output": "<tricyclic antidepressants, mechanism, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Transient delirium has been reported in patients who were treated with one gram of ethchlorvynol and 75 - 150 mg of amitriptyline HCl.", "output": "<ethchlorvynol, effect, amitriptyline HCl>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with Tiazac.", "output": "<beta-blockers, effect, Tiazac>, <digitalis, effect, Tiazac>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of diltiazem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%.", "output": "<diltiazem hydrochloride, mechanism, propranolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In vitro, propranolol appears to be displaced from its binding sites by diltiazem.", "output": "<propranolol, mechanism, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and AUC (53%) after a 1-week course of cimetidine 1200 mg/day and a single dose of diltiazem 60mg.", "output": "<cimetidine, mechanism, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The effect may be mediated by cimetidines known inhibition of hepatic cytochrome P-450, the enzyme system responsible for the first-pass metabolism of diltiazem.", "output": "<cimetidine, mechanism, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients currently receiving diltiazem therapy should be carefully monitored for a change in pharmacological effect when initiating and discontinuing therapy with cimetidine.", "output": "<diltiazem, advise, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%.", "output": "<diltiazem hydrochloride, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since there have been conflicting results regarding the effect of digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing diltiazem hydrochloride therapy to avoid possible over- or under-digitalization.", "output": "<digoxin, advise, diltiazem hydrochloride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The depression of cardiac contractility, conductivity, and automaticity as well as the vascular dilation associated with anesthetics may be potentiated by calcium channel blockers.", "output": "<anesthetics, effect, calcium channel blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When used concomitantly, anesthetics and calcium channel blockers should be titrated carefully.", "output": "<anesthetics, advise, calcium channel blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A pharmacokinetic interaction between diltiazem and cyclosporine has been observed during studies involving renal and cardiac transplant patients.", "output": "<diltiazem, int, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of diltiazem.", "output": "<cyclosporine, mechanism, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when diltiazem therapy is initiated, adjusted, or discontinued.", "output": "<cyclosporine, advise, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine (40% to 72% increase), resulting in toxicity in some cases.", "output": "<diltiazem, mechanism, carbamazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3-4 fold and the Cmax by 2-fold, compared to placebo.", "output": "<diltiazem, mechanism, midazolam>, <diltiazem, mechanism, triazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The elimination half life of midazolam and triazolam also increased (1.5-2.5 fold) during coadministration with diltiazem.", "output": "<midazolam, mechanism, diltiazem>, <triazolam, mechanism, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sodation)of both midazolam and triazolam.", "output": "<diltiazem, effect, midazolam>, <diltiazem, effect, triazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a ten-subject study, coadministration of diltiazem (120 mg bid) with lovastatin resulted in a 3-4 times increase in mean lovastatin AUC and Cmax vs. lovastatin alone;", "output": "<diltiazem, mechanism, lovastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels.", "output": "<rifampin, mechanism, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of diltiazem with rifampin or any known CYP3A4 inducer should be avoided when possible, and alternative therapy considered.", "output": "<diltiazem, advise, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Combinations of these drugs have not been studied and coadministration of CRIXIVAN and atazanavir is not recommended.", "output": "<CRIXIVAN, advise, atazanavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dose reduction of CRIXIVAN to 600 mg every 8 hours should be considered when taking delavirdine 400 mg three times a day.", "output": "<CRIXIVAN, advise, delavirdine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Indinavir and didanosine formulations containing buffer should be administered at least one hour apart on an empty stomach.", "output": "<Indinavir, advise, didanosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Increasing the indinavir dose to 1000 mg every 8 hours does not compensate for the increased indinavir metabolism due to efavirenz.", "output": "<indinavir, mechanism, efavirenz>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Indinavir concentrations may be decreased in the presence of nevirapine.", "output": "<Indinavir, mechanism, nevirapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Preliminary clinical data suggest that the incidence of nephrolithiasis is higher in patients receiving indinavir in combination with ritonavir than those receiving CRIXIVAN 800 mg q8h.", "output": "<indinavir, effect, ritonavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution is warranted and therapeutic concentration monitoring is recommended for antiarrhythmics when coadministered with CRIXIVAN.", "output": "<antiarrhythmics, advise, CRIXIVAN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "CRIXIVAN may not be effective due to decreased indinavir concentrations in patients taking these agents concomitantly.", "output": "<CRIXIVAN, effect, indinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Use lowest possible dose of atorvastatin with careful monitoring, or consider HMG-CoA reductase inhibitors that are not primarily metabolized by CYP3A4, such as pravastatin, fluvastatin, or rosuvastatin in combination with CRIXIVAN.", "output": "<atorvastatin, advise, CRIXIVAN>, <HMG-CoA reductase inhibitors, advise, CRIXIVAN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dose reduction of CRIXIVAN to 600 mg every 8 hours is recommended when administering itraconazole concurrently.", "output": "<CRIXIVAN, advise, itraconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dose reduction of rifabutin to half the standard dose and a dose increase of CRIXIVAN to 1000 mg (three 333-mg capsules) every 8 hours are recommended when rifabutin and CRIXIVAN are coadministered.", "output": "<rifabutin, advise, CRIXIVAN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sildenafil dose should not exceed a maximum of 25 mg in a 48- hour period in patients receiving concomitant indinavir therapy.", "output": "<Sildenafil, advise, indinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tadalafil dose should not exceed a maximum of 10 mg in a 72- hour period in patients receiving concomitant indinavir therapy.", "output": "<Tadalafil, advise, indinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Vardenafil dose should not exceed a maximum of 2.5 mg in a 24-hour period in patients receiving concomitant indinavir therapy.", "output": "<Vardenafil, advise, indinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digoxin: Coadministration of digoxin, a P-glycoprotein substrate, with oral conivaptan resulted in a reduction in clearance and an increase in digoxin Cmax and AUC values.", "output": "<digoxin, mechanism, conivaptan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, if digoxin is administered with VAPRISOL, the clinician should be alert to the possibility of increases in digoxin levels.", "output": "<digoxin, mechanism, VAPRISOL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been isolated reports of patients experiencing increases in their prothrombin times when etidronate was added to warfarin therapy.", "output": "<etidronate, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Wait 5 weeks after stopping escitalopram before starting a non-selective MAO inhibitor.", "output": "<escitalopram, advise, non-selective MAO inhibitor>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Wait 2 weeks after stopping an MAO inhibitor before starting escitalopram.", "output": "<MAO inhibitor, advise, escitalopram>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity.", "output": "<Erythromycin, effect, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In case of theophylline toxicity and/or elevated serum theophylline levels, the dose of theophylline should be reduced while the patient is receiving concomitant erythromycin therapy.", "output": "<theophylline, advise, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of erythromycin and digoxin has been reported to result in elevated digoxin serum levels.", "output": "<erythromycin, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been reports of increased anticoagulant effects when erythromycin and oral anticoagulants were used concomitantly.", "output": "<erythromycin, effect, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent use of erythromycin and ergotamine or dihydroergotamine has been associated in some patients with acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia.", "output": "<erythromycin, effect, ergotamine>, <erythromycin, effect, dihydroergotamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Erythromycin has been reported to decrease the clearance of triazolam and midazolam and thus may increase the pharmacologic effect of these benzodiazepines.", "output": "<Erythromycin, mechanism, triazolam>, <Erythromycin, mechanism, midazolam>, <Erythromycin, effect, benzodiazepines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been reports of interactions of erythromycin with carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfentanil, cisapride, disopyramide, lovastatin, bromocriptine, valproate, terfenadine, and astemizole.", "output": "<erythromycin, int, carbamazepine>, <erythromycin, int, cyclosporine>, <erythromycin, int, tacrolimus>, <erythromycin, int, hexobarbital>, <erythromycin, int, phenytoin>, <erythromycin, int, alfentanil>, <erythromycin, int, cisapride>, <erythromycin, int, disopyramide>, <erythromycin, int, lovastatin>, <erythromycin, int, bromocriptine>, <erythromycin, int, valproate>, <erythromycin, int, terfenadine>, <erythromycin, int, astemizole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Erythromycin has been reported to significantly alter the metabolism of nonsedating antihistamines terfenadine and astemizole when taken concomitantly.", "output": "<Erythromycin, mechanism, terfenadine>, <Erythromycin, mechanism, astemizole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition, deaths have been reported rarely with concomitant administration of terfenadine and erythromycin.", "output": "<terfenadine, effect, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been postmarketing reports of drug interactions when erythromycin is coadministered with cisapride, resulting in QT prolongation, cardiac arrythmias, ventricular tachycardia, ventricular fibrulation, and torsades de pointes, most like due to inhibition of hepatic metabolism of cisapride by erythromycin.", "output": "<erythromycin, effect, cisapride>, <cisapride, mechanism, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients receiving concomitant lovastatin and erythromycin should be carefully monitored;", "output": "<lovastatin, advise, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.", "output": "<tetracyclines, advise, anticoagulant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since bacteriostatic drugs, such as the tetracycline class of antibiotics, may interfere with the bactericidal action of penicillins, it is not advisable to administer these drugs concomitantly.", "output": "<tetracycline class, effect, penicillins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.", "output": "<tetracyclines, effect, contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Increases in prothrombin time have been noted in patients receiving long- term warfarin therapy after flutamide was initiated.", "output": "<warfarin, effect, flutamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, close monitoring of prothrombin time is recommended and adjustment of the anticoagulant dose may be necessary when EULEXIN Capsules are administered concomitantly with warfarin.", "output": "<EULEXIN, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "in one man, the C max of terfenadine was 8.1 ng/mL with terfenadine alone and 7.2 ng/mL with terfenadine plus dirithromycin.", "output": "<terfenadine, mechanism, dirithromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The mean QT c interval (msec) was 369 with terfenadine alone and 367 with terfenadine plus dirithromycin.", "output": "<terfenadine, effect, dirithromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus, the interaction observed between erythromycin and terfenadine is not expected for dirithromycin.", "output": "<erythromycin, int, terfenadine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Serious cardiac dysrhythmias, some resulting in death, have occurred in patients receiving terfenadine concomitantly with other macrolide antibiotics.", "output": "<terfenadine, effect, macrolide antibiotics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition, most macrolides are contraindicated in patients receiving terfenadine therapy who have pre-existing cardiac abnormalities (arrhythmia, bradycardia, QT c interval prolongation, ischemic heart disease, congestive heart failure, etc.) or electrolyte disturbances.", "output": "<macrolides, advise, terfenadine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids or H 2 receptor antagonists: When dirithromycin is administered immediately following antacids or H 2 -receptor antagonists, the absorption of dirithromycin is slightly enhanced.", "output": "<dirithromycin, mechanism, antacids>, <dirithromycin, mechanism, H 2 -receptor antagonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Triazolam: Erythromycin has been reported to decrease the clearance of triazolam and, thus, may increase the pharmacologic effect of triazolam.", "output": "<Erythromycin, mechanism, triazolam>, <Erythromycin, effect, triazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digoxin: Concomitant administration of erythromycin and digoxin has been reported to result in elevated digoxin serum levels.", "output": "<erythromycin, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticoagulants: There have been reports of increased anticoagulant effects when erythromycin and oral anticoagulants were used concomitantly.", "output": "<erythromycin, effect, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ergotamine: Concurrent use of erythromycin and ergotamine or dihydroergotamine has been associated in some patients with acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia.", "output": "<erythromycin, effect, ergotamine>, <erythromycin, effect, dihydroergotamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other drugs Drug interactions have been reported with concomitant administration of erythromycin and other medications, including cyclosporine, hexobarbital, carbamazepine, alfentanil, disopyramide, phenytoin, bromocriptine, valproate, astemizole, and lovastatin.", "output": "<erythromycin, int, cyclosporine>, <erythromycin, int, hexobarbital>, <erythromycin, int, carbamazepine>, <erythromycin, int, alfentanil>, <erythromycin, int, disopyramide>, <erythromycin, int, phenytoin>, <erythromycin, int, bromocriptine>, <erythromycin, int, valproate>, <erythromycin, int, astemizole>, <erythromycin, int, lovastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The safety and efficacy of concomitant use of REVIA and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.", "output": "<REVIA, effect, disulfiram>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lethargy and somnolence have been reported following doses of REVIA and thioridazine.", "output": "<REVIA, effect, thioridazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients taking REVIA may not benefit from opioid containing medicines, such as cough and cold preparations, antidiarrheal preparations, and opioid analgesics.", "output": "<REVIA, effect, opioid>, <REVIA, effect, opioid analgesics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In an emergency situation when opioid analgesia must be administered to a patient receiving REVIA, the amount of opioid required may be greater than usual, and the resulting respiratory depression may be deeper and more prolonged.", "output": "<REVIA, effect, opioid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cholestyramine and colestipol resins: Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.", "output": "<hydrochlorothiazide, mechanism, anionic exchange resins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively.", "output": "<cholestyramine, mechanism, hydrochlorothiazide>, <colestipol, mechanism, hydrochlorothiazide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: generally should not be given with diuretics.", "output": "<Lithium, advise, diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.", "output": "<Diuretic agents, mechanism, lithium>, <Diuretic agents, effect, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Refer to the package insert for lithium preparations before use of such preparations with Hydrochlorothiazide.", "output": "<lithium, advise, Hydrochlorothiazide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Non-steroidal Anti-inflammatory Drugs: In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.", "output": "<non-steroidal anti-inflammatory agent, effect, loop diuretics>, <non-steroidal anti-inflammatory agent, effect, potassium-sparing diuretics>, <non-steroidal anti-inflammatory agent, effect, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, when Hydrochlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.", "output": "<Hydrochlorothiazide, advise, non-steroidal anti-inflammatory agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.", "output": "<cephalosporins, effect, aminoglycoside antibiotics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients who are applying Panretin gel should not concurrently use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products.", "output": "<Panretin, advise, DEET>, <Panretin, advise, N-diethyl-m-toluamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sulfacetamide preparations are incompatible with silver preparations.", "output": "<Sulfacetamide, int, silver>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, iloprost has the potential to increase the hypotensive effect of vasodilators and antihypertensive agents.", "output": "<iloprost, effect, vasodilators>, <iloprost, effect, antihypertensive agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since iloprost inhibits platelet function, there is a potential for increased risk of bleeding, particularly in patients maintained on anticoagulants.", "output": "<iloprost, effect, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "RAPTIVA should not be used with other immunosuppressive drugs.", "output": "<RAPTIVA, advise, immunosuppressive drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acellular, live and live-attenuated vaccines should not be administered during RAPTIVA treatment.", "output": "<Acellular vaccines, advise, RAPTIVA>, <live vaccines, advise, RAPTIVA>, <live-attenuated vaccines, advise, RAPTIVA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Mineral oil interferes with the absorption of fat-soluble vitamins, including vitamin D preparations.", "output": "<Mineral oil, mechanism, fat-soluble vitamins>, <Mineral oil, mechanism, vitamin D preparations>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with ergocalciferol may cause hypercalcemia.", "output": "<thiazide diuretics, effect, ergocalciferol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Netilmicin should not be administered concomitantly with potent loop diuretics such as furosemide and ethacrynic acid as the potential for ototoxicity is enhanced by the combination.", "output": "<Netilmicin, advise, loop diuretics>, <Netilmicin, advise, furosemide>, <Netilmicin, advise, ethacrynic acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Bentiromide may interact with acetaminophen (e.g., Tylenol), chloramphenicol (e.g., Chloromycetin), local anesthetics (e.g., benzocaine and lidocaine), para-aminobenzoic acid (PABA)-containing preparations (e.g., sunscreens and some multivitamins), procainamide (e.g., Pronestyl), sulfonamides (sulfa medicines), thiazide diuretics (use of these medicines during the test period will affect the test results), and pancreatic supplements (use of pancreatic supplements may give false test results).", "output": "<Bentiromide, int, acetaminophen>, <Bentiromide, int, Tylenol>, <Bentiromide, int, chloramphenicol>, <Bentiromide, int, Chloromycetin>, <Bentiromide, int, anesthetics>, <Bentiromide, int, benzocaine>, <Bentiromide, int, lidocaine>, <Bentiromide, int, para-aminobenzoic acid>, <Bentiromide, int, PABA>, <Bentiromide, int, multivitamins>, <Bentiromide, int, procainamide>, <Bentiromide, int, Pronestyl>, <Bentiromide, int, sulfonamides>, <Bentiromide, int, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, the risk of hyperkalemia may be increased.", "output": "<amiloride, effect, angiotensin-converting enzyme inhibitor>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.", "output": "<Lithium, advise, diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.", "output": "<non-steroidal anti-inflammatory agent, effect, loop diuretics>, <non-steroidal anti-inflammatory agent, effect, potassium-sparing diuretics>, <non-steroidal anti-inflammatory agent, effect, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, when MIDAMOR and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.", "output": "<MIDAMOR, advise, non-steroidal anti-inflammatory agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since indomethacin and potassium-sparing diuretics, including MIDAMOR, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.", "output": "<indomethacin, effect, potassium-sparing diuretics>, <indomethacin, effect, MIDAMOR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Drugs with ototoxic potential: Especially in the presence of impaired renal function, the use of parenterally administered bumetanide in patients to whom aminoglycoside antibiotics are also being given should be avoided, except in life-threatening conditions.", "output": "<bumetanide, advise, aminoglycoside antibiotics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Lithium: Lithium should generally not be given with diuretics (such as bumetanide) because they reduce its renal clearance and add a high risk of lithium toxicity.", "output": "<Lithium, advise, diuretics>, <Lithium, advise, bumetanide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Probenecid: Pretreatment with probenecid reduces both the natriuresis and hyperreninemia produced by bumetanide.", "output": "<probenecid, effect, bumetanide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This antagonistic effect of probenecid on bumetanide natriuresis is not due to a direct action on sodium excretion but is probably secondary to its inhibitory effect on renal tubular secretion of bumetanide.", "output": "<probenecid, mechanism, bumetanide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus, probenecid should not be administered concurrently with bumetanide.", "output": "<probenecid, advise, bumetanide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Indomethacin: Indomethacin blunts the increases in urine volume and sodium excretion seen during bumetanide treatment and inhibits the bumetanide-induced increase in plasma renin activity.", "output": "<Indomethacin, mechanism, bumetanide>, <Indomethacin, effect, bumetanide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Antihypertensives: Bumetanide may potentiate the effect of various antihypertensive drugs, necessitating a reduction in the dosage of these drugs.", "output": "<Bumetanide, effect, antihypertensive drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents.", "output": "<sulfonylureas, effect, nonsteroidal anti-inflammatory agents>, <sulfonylureas, effect, salicylates>, <sulfonylureas, effect, sulfonamides>, <sulfonylureas, effect, chloramphenicol>, <sulfonylureas, effect, probenecid>, <sulfonylureas, effect, coumarins>, <sulfonylureas, effect, monoamine oxidase inhibitors>, <sulfonylureas, effect, beta adrenergic blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A possible interaction between glyburide and ciprofloxacin, a fluoroquinolone antibiotic, has been reported, resulting in a potentiation of the hypoglycemic action of glyburide.", "output": "<glyburide, int, ciprofloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported.", "output": "<miconazole, effect, hypoglycemic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects an blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide.", "output": "<anticoagulants, effect, chlordiazepoxide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Azlocillin should not be administered concomitantly with amikacin, ciprofloxacin, gentamicin, netilmicin, or tobramycin.", "output": "<Azlocillin, advise, amikacin>, <Azlocillin, advise, ciprofloxacin>, <Azlocillin, advise, gentamicin>, <Azlocillin, advise, netilmicin>, <Azlocillin, advise, tobramycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ZEBETA should not be combined with other beta-blocking agents.", "output": "<ZEBETA, advise, beta-blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients receiving catecholamine-depleting drugs, such as reserpine or guanethidine, should be closely monitored, because the added beta-adrenergic blocking action of ZEBETA may produce excessive reduction of sympathetic activity.", "output": "<reserpine, effect, ZEBETA>, <guanethidine, effect, ZEBETA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients receiving concurrent therapy with clonidine, if therapy is to be discontinued, it is suggested that ZEBETA be discontinued for several days before the withdrawal of clonidine.", "output": "<ZEBETA, advise, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ZEBETA should be used with care when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide, are used concurrently.", "output": "<ZEBETA, advise, myocardial depressants>, <ZEBETA, advise, calcium antagonists>, <ZEBETA, advise, phenylalkylamine>, <ZEBETA, advise, verapamil>, <ZEBETA, advise, benzothiazepine>, <ZEBETA, advise, diltiazem>, <ZEBETA, advise, antiarrhythmic agents>, <ZEBETA, advise, disopyramide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent use of rifampin increases the metabolic clearance of ZEBETA, resulting in a shortened elimination half-life of ZEBETA.", "output": "<rifampin, mechanism, ZEBETA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and folic acid.", "output": "<vitamin B12, int, folic acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids containing magnesium trisilicate, when administered concomitantly with nitrofurantoin, reduce both the rate and extent of absorption.", "output": "<magnesium trisilicate, mechanism, nitrofurantoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The mechanism for this interaction probably is adsorption of nitrofurantoin onto the surface of magnesium trisilicate.", "output": "<nitrofurantoin, mechanism, magnesium trisilicate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin.", "output": "<Uricosuric drugs, mechanism, nitrofurantoin>, <probenecid, mechanism, nitrofurantoin>, <sulfinpyrazone, mechanism, nitrofurantoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent administration of drugs possessing nephrotoxic (e.g., aminoglycosides, indomethacin), myelotoxic (e.g., cytotoxic chemotherapy), cardiotoxic (e.g., doxorubicin) or hepatotoxic (e.g., methotrexate, asparaginase) effects with PROLEUKIN may increase toxicity in these organ systems.", "output": "<aminoglycosides, effect, PROLEUKIN>, <indomethacin, effect, PROLEUKIN>, <cytotoxic, effect, PROLEUKIN>, <doxorubicin, effect, PROLEUKIN>, <methotrexate, effect, PROLEUKIN>, <asparaginase, effect, PROLEUKIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hypersensitivity reactions have been reported in patients receiving combination regimens containing sequential high dose PROLEUKIN and antineoplastic agents, specifically, dacarbazine, cis-platinum, tamoxifen and interferon-alfa.", "output": "<PROLEUKIN, effect, antineoplastic agents>, <PROLEUKIN, effect, dacarbazine>, <PROLEUKIN, effect, cis-platinum>, <PROLEUKIN, effect, tamoxifen>, <PROLEUKIN, effect, interferon-alfa>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Myocardial injury, including myocardial infarction, myocarditis, ventricular hypokinesia, and severe rhabdomyolysis appear to be increased in patients receiving PROLEUKIN and interferon-alfa concurrently.", "output": "<PROLEUKIN, effect, interferon-alfa>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Exacerbation or the initial presentation of a number of autoimmune and inflammatory disorders has been observed following concurrent use of interferon-alfa and PROLEUKIN, including crescentic IgA glomerulonephritis, oculo-bulbar myasthenia gravis, inflammatory arthritis, thyroiditis, bullous pemphigoid, and Stevens-Johnson syndrome.", "output": "<interferon-alfa, effect, PROLEUKIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although glucocorticoids have been shown to reduce PROLEUKIN-induced side effects including fever, renal insufficiency, hyperbilirubinemia, confusion, and dyspnea, concomitant administration of these agents with PROLEUKIN may reduce the antitumor effectiveness of PROLEUKIN and thus should be avoided. 12 Beta-blockers and other antihypertensives may potentiate the hypotension seen with PROLEUKIN.", "output": "<glucocorticoids, effect, PROLEUKIN>, <Beta-blockers, effect, PROLEUKIN>, <antihypertensives, effect, PROLEUKIN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Delayed Adverse Reactions to Iodinated Contrast Media: A review of the literature revealed that 12.6% (range 11-28%) of 501 patients treated with various interleukin-2 containing regimens who were subsequently administered radiographic iodinated contrast media experienced acute, atypical adverse reactions.", "output": "<interleukin-2, effect, radiographic iodinated contrast media>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cevimeline should be administered with caution to patients taking beta adrenergic antagonists, because of the possibility of conduction disturbances.", "output": "<Cevimeline, advise, beta adrenergic antagonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aminosalicylic acid may decrease the amount of digoxin (Lanoxin, Lanoxicaps) that gets absorbed into your body.", "output": "<Aminosalicylic acid, mechanism, digoxin>, <Aminosalicylic acid, mechanism, Lanoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In the case that you are taking digoxin while taking aminosalicylic acid, higher doses of digoxin may be needed.", "output": "<digoxin, advise, aminosalicylic acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aminosalicylic acid may also decrease the absorption of vitamin B12, which can lead to a deficiency.", "output": "<Aminosalicylic acid, mechanism, vitamin B12>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore you may need to take a vitamin B12 supplement while taking aminosalicylic acid.", "output": "<vitamin B12, advise, aminosalicylic acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "PROSTIN E2 may augment the activity of other oxytocic drugs.", "output": "<PROSTIN E2, effect, oxytocic drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins;", "output": "<Cholestyramine, mechanism, fat soluble vitamins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin/Phenobarbital: The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism.", "output": "<phenytoin, mechanism, calcitriol>, <phenobarbital, mechanism, calcitriol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia.", "output": "<thiazides, effect, vitamin D>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias.", "output": "<Vitamin D, advise, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D.", "output": "<Ketoconazole, mechanism, vitamin D>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.", "output": "<vitamin D analogues, mechanism, corticosteroids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.", "output": "<Magnesium, advise, vitamin D>, <antacids, advise, vitamin D>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "May interact with the following: cholestyramine, colestipol (use with thiazide diuretics may prevent the diuretic from working properly;", "output": "<cholestyramine, effect, thiazide diuretics>, <colestipol, effect, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other CNS depressant drugs (e.g. barbiturates, tranquilizers, opioids and general anesthetics) have additive or potentiating effects with INAPSINE.", "output": "<CNS depressant drugs, effect, INAPSINE>, <barbiturates, effect, INAPSINE>, <tranquilizers, effect, INAPSINE>, <opioids, effect, INAPSINE>, <anesthetics, effect, INAPSINE>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Following the administration of INAPSINE, the dose of other CNS depressant drugs should be reduced.", "output": "<INAPSINE, advise, CNS depressant drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously because both drugs are direct cardiac stimulants and their combined effects may induce serious arrhythmias.", "output": "<Isoproterenol hydrochloride, advise, epinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ISUPREL should be used with caution, if at all, when potent inhalational anesthetics such as halothane are employed because of potential to sensitize the myocardium to effects of sympathomimetic amines.", "output": "<ISUPREL, advise, anesthetics>, <ISUPREL, advise, halothane>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The effectiveness of progestin-only pills is reduced by hepatic enzyme-inducing drugs such as the anticonvulsants phenytoin, carbamazepine, and barbiturates, and the antituberculosis drug rifampin.", "output": "<progestin, effect, phenytoin>, <progestin, effect, carbamazepine>, <progestin, effect, barbiturates>, <progestin, effect, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of FACTIVE and calcium carbonate, cimetidine, omeprazole, or an estrogen/progesterone oral contraceptive produced minor changes in the pharmacokinetics of gemifloxacin, which were considered to be without clinical significance.", "output": "<FACTIVE, mechanism, calcium carbonate>, <FACTIVE, mechanism, cimetidine>, <FACTIVE, mechanism, omeprazole>, <FACTIVE, mechanism, estrogen>, <FACTIVE, mechanism, progesterone>, <FACTIVE, mechanism, contraceptive>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of FACTIVE with probenecid resulted in a 45% increase in systemic exposure to gemifloxacin.", "output": "<FACTIVE, mechanism, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, because some quinolones have been reported to enhance the anticoagulant effects of warfarin or its derivatives in patients, the prothrombin time or other suitable coagulation test should be closely monitored if a quinolone antimicrobial is administered concomitantly with warfarin or its derivatives.", "output": "<quinolones, effect, warfarin>, <quinolone antimicrobial, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The absorption of oral gemifloxacin is significantly reduced by the concomitant administration of an antacid containing aluminum and magnesium.", "output": "<gemifloxacin, mechanism, aluminum>, <gemifloxacin, mechanism, magnesium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Magnesium- and/or aluminum-containing antacids, products containing ferrous sulfate (iron), multivitamin preparations containing zinc or other metal cations, or Videx (didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be taken within 3 hours before or 2 hours after FACTIVE.", "output": "<Magnesium, advise, FACTIVE>, <aluminum, advise, FACTIVE>, <ferrous sulfate, advise, FACTIVE>, <iron, advise, FACTIVE>, <multivitamin preparations, advise, FACTIVE>, <zinc, advise, FACTIVE>, <Videx, advise, FACTIVE>, <didanosine, advise, FACTIVE>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sucralfate should not be taken within 2 hours of FACTIVE.", "output": "<Sucralfate, advise, FACTIVE>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Steroids enhance the renal toxicity of edetate calcium disodium in animals. 7 Edetate calcium disodium interferes with the action of zinc insulin preparations by chelating the zinc. 7", "output": "<Steroids, effect, edetate calcium disodium>, <Edetate calcium disodium, mechanism, zinc insulin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "(Concurrent use with thiazide diuretics may enhance the possibility of digitalis toxicity associated with hypokalemia.)", "output": "<thiazide diuretics, effect, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "for adult-onset diabetics, dosage adjustment of hypoglycemic medications may be necessary during and after thiazide diuretic therapy;", "output": "<hypoglycemic medications, advise, thiazide diuretic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "(In some patients, the steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium sparing, and thiazide diuretics.", "output": "<steroidal anti-inflammatory agent, effect, loop diuretics>, <steroidal anti-inflammatory agent, effect, potassium sparing diuretics>, <steroidal anti-inflammatory agent, effect, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, when hydroflumethiazide and nonsteroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.)", "output": "<hydroflumethiazide, advise, nonsteroidal anti-inflammatory agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "(Thiazides may decrease arterial responsiveness to norepinephrine.", "output": "<Thiazides, effect, norepinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "(Thiazide drugs may increase the responsiveness to tubocurarine.)", "output": "<Thiazide drugs, effect, tubocurarine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Experience with co-administration of HMG-CoA reductase inhibitors and Fentanyl in patients is limited,therefore,consideration should be given to temporarily suspending use of HMG-CoA reductase inhibitors in patients receiving Fentanyl.", "output": "<HMG-CoA reductase inhibitors, advise, Fentanyl>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetaminophen and methotrexate - L-methionine may decrease hepatic toxicity in those with acetaminophen overdosage or in those taking methotrexate.", "output": "<L-methionine, effect, acetaminophen>, <L-methionine, effect, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Gentamicin - Methionine may protect against the ototoxic effects of gentamicin.", "output": "<Methionine, effect, gentamicin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although BETAGAN used alone has little or no effect on pupil size, mydriasis resulting from concomitant therapy with BETAGAN and epinephrine may occur.", "output": "<BETAGAN, effect, epinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may produce vertigo, syncope or postural hypotension.", "output": "<beta-blocker, advise, reserpine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients receiving beta-adrenergic blocking agents along with either oral or intravenous calcium antagonists should be monitored for possible atrioventricular conduction disturbances, left ventricular failure and hypotension.", "output": "<beta-adrenergic blocking agents, advise, calcium antagonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant use of beta-adrenergic blocking agents with digitalis and calcium antagonists may have additive effects on prolonging atrioventricular conduction time.", "output": "<beta-adrenergic blocking agents, effect, digitalis>, <beta-adrenergic blocking agents, effect, calcium antagonist>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenothiazine-related compounds and beta-adrenergic blocking agents may have additive hypotensite effects due to the inhibition of each other s metabolism.", "output": "<Phenothiazine-related compounds, mechanism, beta-adrenergic blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "International Normalized Ratio (INR) elevations and/or bleeding events have been reported in some patients taking warfarin while on IRESSA therapy.", "output": "<warfarin, effect, IRESSA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Substances that are potent inhibitors of CYP3A4 activity (eg, ketoconazole and itraconazole) decrease gefitinib metabolism and increase gefitinib plasma concentrations.", "output": "<ketoconazole, mechanism, gefitinib>, <ketoconazole, mechanism, gefitinib>, <itraconazole, mechanism, gefitinib>, <itraconazole, mechanism, gefitinib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that cause significant sustained elevation in gastric pH (histamine H2-receptor antagonists such as ranitidine or cimetidine) may reduce plasma concentrations of IRESSA and therefore potentially may reduce efficacy.", "output": "<histamine H2-receptor antagonists, mechanism, IRESSA>, <ranitidine, mechanism, IRESSA>, <cimetidine, mechanism, IRESSA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phase II clinical trial data, where IRESSA and vinorelbine have been used concomitantly, indicate that IRESSA may exacerbate the neutropenic effect of vinorelbine.", "output": "<IRESSA, effect, vinorelbine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and lorazepam.", "output": "<loxapine, effect, lorazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that may alter imatinib plasma concentrations Drugs that may increase imatinib plasma concentrations: Caution is recommended when administering Gleevec with inhibitors of the CYP3A4 family (e.g., ketoconazole, itraconazole, erythromycin, clarithromycin).", "output": "<Gleevec, advise, ketoconazole>, <Gleevec, advise, itraconazole>, <Gleevec, advise, erythromycin>, <Gleevec, advise, clarithromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There is a significant increase in exposure to imatinib when Gleevec is coadministered with ketoconazole (CYP3A4 inhibitor).", "output": "<Gleevec, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pretreatment of healthy volunteers with multiple doses of rifampin followed by a single dose of Gleevec, increased Gleevec oral-dose clearance by 3.8-fold, which significantly (p 0.05) decreased mean cmax and AUC(0-8).", "output": "<rifampin, mechanism, Gleevec>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drugs that may have their plasma concentration altered by Gleevec Gleevec increases the mean cmax and AUC of simvastatin (CYP3A4 substrate) 2- and 3.5-fold, respectively, suggesting an inhibition of the CYP3A4 by Gleevec.", "output": "<Gleevec, mechanism, simvastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Particular caution is recommended when administering Gleevec with CYP3A4 substrates that have a narrow therapeutic window (e.g., cyclosporine or pimozide).", "output": "<Gleevec, advise, cyclosporine>, <Gleevec, advise, pimozide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Gleevec will increase plasmaconcentration of other CYP3A4 metabolized drugs (e.g., triazolo-benzodiazepines, dihydropyridine calcium channel blockers, certain HMG-CoA reductase inhibitors, etc.).", "output": "<Gleevec, mechanism, benzodiazepines>, <Gleevec, mechanism, dihydropyridine calcium channel blockers>, <Gleevec, mechanism, HMG-CoA reductase inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Systemic exposure to acetaminophen is expected to be increased when coadministered with Gleevec.", "output": "<acetaminophen, mechanism, Gleevec>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A possible drug interaction of FOSCAVIR and intravenous pentamidine has been described.", "output": "<FOSCAVIR, int, pentamidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant treatment of four patients in the United Kingdom with FOSCAVIR and intravenous pentamidine may have caused hypocalcemia;", "output": "<FOSCAVIR, effect, pentamidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because of foscarnets tendency to cause renal impairment, the use of FOSCAVIR should be avoided in combination with potentially nephrotoxic drugs such as aminoglycosides, amphotericin B and intravenous pentamidine unless the potential benefits outweigh the risks to the patient.", "output": "<FOSCAVIR, advise, aminoglycosides>, <FOSCAVIR, advise, amphotericin B>, <FOSCAVIR, advise, pentamidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and naratriptan within 24 hours is contraindicated.", "output": "<ergotamine, advise, naratriptan>, <ergot-type medications, advise, naratriptan>, <dihydroergotamine, advise, naratriptan>, <methysergide, advise, naratriptan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because their vasospastic effects may be additive, coadministration of naratriptan and other 5-HT1 agonists within 24 hours of each other is not recommended.", "output": "<naratriptan, advise, 5-HT1 agonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If concomitant treatment with naratriptan and an SSRI is clinically warranted, appropriate observation of the patient is advised.", "output": "<naratriptan, advise, SSRI>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine at 400 mg BID (the usual prescription dose) co-administered with TIKOSYN (500 mcg BID) for 7 days has been shown to increase dofetilide plasma levels by 58%.", "output": "<Cimetidine, mechanism, TIKOSYN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine at doses of 100 mg BID (OTC dose) resulted in a 13% increase in dofetilide plasma levels (500 mcg single dose).", "output": "<Cimetidine, mechanism, dofetilide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If a patient requires TIKOSYN and anti-ulcer therapy, it is suggested that omeprazole, ranitidine, or antacids (aluminum and magnesium hydroxides) be used as alternatives to cimetidine, as these agents have no effect on the pharmacokinetic profile of TIKOSYN.", "output": "<TIKOSYN, advise, cimetidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of TIKOSYN with verapamil resulted in increases in dofetilide peak plasma levels of 42%, although overall exposure to dofetilide was not significantly increased.", "output": "<TIKOSYN, mechanism, verapamil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In an analysis of the supraventricular arrhythmia and DIAMOND patient populations, the concomitant administration of verapamil with dofetilide was associated with a higher occurrence of torsade de pointes.", "output": "<verapamil, effect, dofetilide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole at 400 mg daily (the maximum approved prescription dose) co-administered with TIKOSYN (500 mcg BID) for 7 days has been shown to increase dofetilide Cmax by 53% in males and 97% in females, and AUC by 41% in males and 69% in females.", "output": "<Ketoconazole, mechanism, TIKOSYN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients receiving HCTZ alone, dofetilide AUC increased by 27% and Cmax by 21%.", "output": "<HCTZ, mechanism, dofetilide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition, drugs that are actively secreted via this route (e.g., triamterene, metformin and amiloride) should be co-administered with care as they might increase dofetilide levels.", "output": "<triamterene, advise, dofetilide>, <metformin, advise, dofetilide>, <amiloride, advise, dofetilide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Inhibitors of this isoenzyme (e.g., macrolide antibiotics, azole antifungal agents, protease inhibitors, serotonin reuptake inhibitors, amiodarone, cannabinoids, diltiazem, grapefruit juice, nefazadone, norfloxacin, quinine, zafirlukast) should be cautiously coadministered with TIKOSYN as they can potentially increase dofetilide levels.", "output": "<macrolide antibiotics, advise, TIKOSYN>, <azole antifungal agents, advise, TIKOSYN>, <protease inhibitors, advise, TIKOSYN>, <serotonin reuptake inhibitors, advise, TIKOSYN>, <amiodarone, advise, TIKOSYN>, <cannabinoids, advise, TIKOSYN>, <diltiazem, advise, TIKOSYN>, <nefazadone, advise, TIKOSYN>, <norfloxacin, advise, TIKOSYN>, <quinine, advise, TIKOSYN>, <zafirlukast, advise, TIKOSYN>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients, the concomitant administration of digoxin with dofetilide was associated with a higher occurrence of torsade de pointes.", "output": "<digoxin, effect, dofetilide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The mean clearances of dofetilide were 16% and 15% lower in patients on thiazide diuretics and inhibitors of tubular organic cation transport, respectively.", "output": "<dofetilide, mechanism, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Intravenous ranitidine was shown to double the bioavailability of oral alendronate.", "output": "<ranitidine, mechanism, alendronate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Products containing calcium and other multivalent cations likely will interfere with absorption of alendronate.", "output": "<calcium, mechanism, alendronate>, <multivalent cations, mechanism, alendronate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Clinical studies with celecoxib have identified potentially significant interactions with fluconazole and lithium.", "output": "<celecoxib, int, fluconazole>, <celecoxib, int, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Experience with nonsteroidal anti-inflammatory drugs (NSAIDs) suggests the potential for interactions with furosemide and ACE inhibitors.", "output": "<nonsteroidal anti-inflammatory drugs, int, furosemide>, <nonsteroidal anti-inflammatory drugs, int, ACE inhibitors>, <NSAIDs, int, furosemide>, <NSAIDs, int, ACE inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors.", "output": "<NSAIDs, effect, Angiotensin Converting Enzyme (ACE) inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This interaction should be given consideration in patients taking CELEBREX concomitantly with ACE-inhibitors.", "output": "<CELEBREX, advise, ACE-inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide: Clinical studies, as well as post marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.", "output": "<NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: CELEBREX can be used with low dose aspirin.", "output": "<CELEBREX, advise, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, concomitant administration of aspirin with CELEBREX may result in an increased rate of GI ulceration or other complications, compared to use of CELEBREX alone.", "output": "<aspirin, effect, CELEBREX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Fluconazole: Concomitant administration of fluconazole at 200 mg QD resulted in a two-fold increase in celecoxib plasma concentration.", "output": "<fluconazole, mechanism, celecoxib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This increase is due to the inhibition of celecoxib metabolism via P450 2C9 by fluconazole (see CLINICAL PHARMACOLOGY - Pharmacokinetics: Metabolism).", "output": "<celecoxib, mechanism, fluconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "CELEBREX should be introduced at the lowest recommended dose in patients receiving fluconazole.", "output": "<CELEBREX, advise, fluconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: In a study conducted in healthy subjects, mean steady-state lithium plasma levels increased approximately 17% in subjects receiving lithium 450 mg BID with CELEBREX 200 mg BID as compared to subjects receiving lithium alone.", "output": "<lithium, mechanism, CELEBREX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients on lithium treatment should be closely monitored when CELEBREX is introduced or withdrawn.", "output": "<lithium, advise, CELEBREX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, caution should be used when administering CELEBREX with warfarin since these patients are at increased risk of bleeding complications.", "output": "<CELEBREX, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Medroxyprogesterone Acetate - L-histidine was observed to enhance (in tissue culture) the effect of medroxyprogesterone acetate in reducing the number of human breast cancer cells that were in the S phase.", "output": "<L-histidine, effect, medroxyprogesterone acetate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "H1 and H2 Blockers - Although not reported, L-histidine, via its metabolism to histamine, might decrease the efficacy of H1 and H2 blockers.", "output": "<L-histidine, effect, H1 blockers>, <L-histidine, effect, H2 blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving systemic cyclosporine concomitantly.", "output": "<quinolones, mechanism, theophylline>, <quinolones, mechanism, caffeine>, <quinolones, effect, warfarin>, <quinolones, effect, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Erythromycin (500 mg t.i.d) produced a 4-fold increase in vardenafil AUC and a 3-fold increase in Cmax when co-administered with Vardenafil 5 mg in healthy volunteers.", "output": "<Erythromycin, mechanism, vardenafil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended not to exceed a single 5 mg dose of Vardenafil in a 24-hour period when used in combination with erythromycin.", "output": "<Vardenafil, advise, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole (200 mg once daily) produced a 10-fold increase in vardenafil AUC and a 4-fold increase in Cmax when co-administered with Vardenafil (5 mg) in healthy volunteers.", "output": "<Ketoconazole, mechanism, vardenafil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A 5-mg Vardenafil dose should not be exceeded when used in combination with 200 mg once daily ketoconazole.", "output": "<Vardenafil, advise, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since higher doses of ketoconazole (400 mg daily) may result in higher increases in Cmax and AUC, a single 2.5 mg dose of Vardenafil should not be exceeded in a 24-hour period when used in combination with ketoconazole 400 mg daily.", "output": "<Vardenafil, advise, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "HIV Protease Inhibitors: Indinavir (800 mg t.i.d.) co-administered with Vardenafil 10 mg resulted in a 16-fold increase in vardenafil AUC, a 7-fold increase in vardenafil Cmax and a 2-fold increase in vardenafil half-life.", "output": "<Indinavir, mechanism, Vardenafil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended not to exceed a single 2.5 mg Vardenafil dose in a 24-hour period when used in combination with indinavir.", "output": "<Vardenafil, advise, indinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ritonavir (600 mg b.i.d.) co-administered with Vardenafil 5 mg resulted in a 49-fold increase in vardenafil AUC and a 13-fold increase in vardenafil Cmax.", "output": "<Ritonavir, mechanism, Vardenafil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The interaction is a consequence of blocking hepatic metabolism of vardenafil by ritonavir, a highly potent CYP3A4 inhibitor, which also inhibits CYP2C9.", "output": "<vardenafil, mechanism, ritonavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ritonavir significantly prolonged the half-life of vardenafil to 26 hours.", "output": "<Ritonavir, mechanism, vardenafil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Consequently, it is recommended not to exceed a single 2.5 mg Vardenafil dose in a 72-hour period when used in combination with ritonavir.", "output": "<Vardenafil, advise, ritonavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In vivo studies: Nitrates: The blood pressure lowering effects of sublingual nitrates (0.4 mg) taken 1 and 4 hours after vardenafil and increases in heart rate when taken at 1, 4 and 8 hours were potentiated by a 20 mg dose of Vardenafil in healthy middle-aged subjects.", "output": "<nitrates, mechanism, vardenafil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Potentiation of the hypotensive effects of nitrates for patients with ischemic heart disease has not been evaluated, and concomitant use of Vardenafil and nitrates is contraindicated.", "output": "<Vardenafil, advise, nitrates>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In these patients whose hypertension was controlled with nifedipine, Vardenafil 20 mg produced mean additional supine systolic/diastolic blood pressure reductions of 6/5 mm Hg compared to placebo.", "output": "<nifedipine, effect, Vardenafil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Alpha-blockers: When Vardenafil 10 or 20 mg was given to healthy volunteers either simultaneously or 6 hours after a 10 mg dose of terazosin, significant hypotension developed in a substantial number of subjects.", "output": "<Vardenafil, effect, terazosin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "With simultaneous dosing of Vardenafil 10 mg and terazosin 10 mg, 6 of 8 subjects experienced a standing systolic blood pressure of less than 85 mm Hg.", "output": "<Vardenafil, effect, terazosin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "With simultaneous dosing of Vardenafil 20 mg and terazosin 10 mg, 2 of 9 subjects experienced a standing systolic blood pressure of less than 85 mm Hg.", "output": "<Vardenafil, effect, terazosin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When Vardenafil dosing was separated from terazosin 10 mg by 6 hours, 7 of 28 subjects who received 20 mg of Vardenafil experienced a decrease in standing systolic blood pressure below 85 mm Hg.", "output": "<Vardenafil, effect, terazosin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a similar study with tamsulosin in healthy volunteers, 1 of 24 subjects dosed with Vardenafil 20 mg and tamsulosin 0.4 mg separated by 6 hours experienced a standing systolic blood pressure below 85 mm Hg.", "output": "<Vardenafil, effect, tamsulosin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Two of 16 subjects dosed simultaneously with Vardenafil 10 mg and tamsulosin 0.4 mg experienced a standing systolic blood pressure below 85 mm Hg.", "output": "<Vardenafil, effect, tamsulosin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Based on these data, Vardenafil should not be used in patients on alpha-blocker therapy.", "output": "<Vardenafil, advise, alpha-blocker>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ritonavir and indinavir: Upon concomitant administration of 5 mg of Vardenafil with 600 mg BID ritonavir, the Cmax and AUC of ritonavir were reduced by approximately 20%.", "output": "<Vardenafil, mechanism, ritonavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Upon administration of 10 mg of Vardenafil with 800 mg TID indinavir, the Cmax and AUC of indinavir were reduced by 40% and 30%, respectively.", "output": "<Vardenafil, mechanism, indinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In vitro studies have shown that the metabolism of docetaxel may be modified by the concomitant administration of compounds that induce, inhibit, or are metabolized by cytochrome P450 3A4, such as cyclosporine, terfenadine, ketoconazole, erythromycin, and troleandomycin.", "output": "<docetaxel, mechanism, cyclosporine>, <docetaxel, mechanism, terfenadine>, <docetaxel, mechanism, ketoconazole>, <docetaxel, mechanism, erythromycin>, <docetaxel, mechanism, troleandomycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid: As with other b-lactam antibiotics, renal excretion of loracarbef is inhibited by probenecid and resulted in an approximate 80% increase in the AUC for loracarbef.", "output": "<b-lactam antibiotics, mechanism, probenecid>, <loracarbef, mechanism, probenecid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients stabilized on oral anticoagulants who are found to require thyroid replacement therapy should be watched very closely when thyroid is started.", "output": "<anticoagulants, advise, thyroid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cholestyramine: Cholestyramine binds both T4 and T3 in the intestine, thus impairing absorption of these thyroid hormones.", "output": "<Cholestyramine, mechanism, T4>, <Cholestyramine, mechanism, T3>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, 4 to 5 hours should elapse between administration of cholestyramine and thyroid hormones.", "output": "<cholestyramine, advise, thyroid hormones>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a patient with a nonfunctioning thyroid gland who is receiving thyroid replacement therapy, free levothyroxine may be decreased when estrogens are started thus increasing thyroid requirements.", "output": "<levothyroxine, mechanism, estrogens>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, patients without a functioning thyroid gland who are on thyroid replacement therapy may need to increase their thyroid dose if estrogens or estrogen-containing oral contraceptives are given.", "output": "<thyroid, advise, estrogens>, <thyroid, advise, contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tricyclic Antidepressants: Use of thyroid products with imipramine and other tricyclic antidepressants may increase receptor sensitivity and enhance antidepressant activity transient cardiac arrhythmias have been observed.", "output": "<thyroid products, effect, imipramine>, <thyroid products, effect, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digitalis: Thyroid preparations may potentiate the toxic effects of digitalis.", "output": "<Thyroid preparations, effect, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketamine: When administered to patients on a thyroid preparation, this parenteral anesthetic may cause hypertension and tachycardia.", "output": "<thyroid preparation, effect, anesthetic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Vasopressors: Thyroxine increases the adrenergic effect of catecholamines such as epinephrine and norepinephrine.", "output": "<Thyroxine, effect, epinephrine>, <Thyroxine, effect, norepinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Results of preliminary studies in humans and rats suggest that nonabsorbable antacids given concurrently with lactulose may inhibit the desired lactulose-induced drop in colonic pH.", "output": "<antacids, mechanism, lactulose>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity.", "output": "<FLUDARA, advise, pentostatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anafranil should not be used with MAO inhibitors.", "output": "<Anafranil, advise, MAO inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Close supervision and careful adjustment of dosage are required when Anafranil is administered with anticholinergic or sympathomimetic drugs.", "output": "<Anafranil, advise, anticholinergic>, <Anafranil, advise, sympathomimetic drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Several tricyclic antidepressants have been reported to block the pharmacologic effects of guanethidine, clonidine, or similar agents, and such an effect may be anticipated with CMI because of its structural similarity to other tricyclic antidepressants.", "output": "<tricyclic antidepressants, effect, guanethidine>, <tricyclic antidepressants, effect, clonidine>, <tricyclic antidepressants, effect, CMI>, <tricyclic antidepressants, effect, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The plasma concentration of CMI has been reported to be increased by the concomitant administration of haloperidol;", "output": "<CMI, mechanism, haloperidol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "plasma levels of several closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of methylphenidate or hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and such an effect may be anticipated with CMI as well.", "output": "<tricyclic antidepressants, mechanism, methylphenidate>, <tricyclic antidepressants, mechanism, cimetidine>, <tricyclic antidepressants, mechanism, fluoxetine>, <tricyclic antidepressants, mechanism, barbiturates>, <tricyclic antidepressants, mechanism, phenytoin>, <methylphenidate, mechanism, CMI>, <cimetidine, mechanism, CMI>, <fluoxetine, mechanism, CMI>, <barbiturates, mechanism, CMI>, <phenytoin, mechanism, CMI>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of CMI has been reported to increase the plasma levels of phenobarbital, if given concomitantly.", "output": "<CMI, mechanism, phenobarbital>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Fluvoxamine has also been shown to inhibit P450 1A2, an isoform also involved in TCAmetabolism.", "output": "<Fluvoxamine, mechanism, TCA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The extent to which SSRI-TCAinteractions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.", "output": "<SSRI, int, TCA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nevertheless, caution is indicated in the co-administration of TCAs with any of the SSRIs and also in switching from one class to the other.", "output": "<TCAs, advise, SSRIs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Of particular importance, sufficient time must elapse before initiating TCAtreatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary).", "output": "<TCA, advise, fluoxetine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because Anafranil is highly bound to serum protein, the administration of Anafranil to patients taking other drugs that are highly bound to protein (e.g., warfarin, digoxin) may cause an increase in plasma concentrations of these drugs, potentially resulting in adverse effects.", "output": "<Anafranil, mechanism, warfarin>, <Anafranil, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digitalis toxicity may be aggravated by the initial release of norepinephrine caused by Bretylium Tosylate Injection.", "output": "<Digitalis, effect, Bretylium Tosylate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The pressor effects of catecholamines such as dopamine or norepinephrine are enhanced by Bretylium Tosylate.", "output": "<catecholamines, effect, Bretylium Tosylate>, <dopamine, effect, Bretylium Tosylate>, <norepinephrine, effect, Bretylium Tosylate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Isoflurane potentiates the muscle relaxant effect of all muscle relaxants, most notably nondepolarizing muscle relaxants, and MAC (minimum alveolar concentration) is reduced by concomitant administration of N 2O.", "output": "<Isoflurane, effect, muscle relaxants>, <Isoflurane, effect, nondepolarizing muscle relaxants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Barbiturates may decrease the effectiveness of oral contraceptives, certain antibiotics, quinidine, theophylline, corticosteroids, anticoagulants, and beta blockers.", "output": "<Barbiturates, effect, contraceptives>, <Barbiturates, effect, antibiotics>, <Barbiturates, effect, quinidine>, <Barbiturates, effect, theophylline>, <Barbiturates, effect, corticosteroids>, <Barbiturates, effect, anticoagulants>, <Barbiturates, effect, beta blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients who have been treated with MAO inhibitors within two to three weeks prior to the administration of dopamine HCl should receive initial doses of dopamine HCl no greater than one-tenth (1/10) of the usual dose.", "output": "<MAO inhibitors, advise, dopamine HCl>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent administration of low-dose dopamine HCl and diuretic agents may produce an additive or potentiating effect on urine flow.", "output": "<dopamine HCl, effect, diuretic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cardiac effects of dopamine are antagonized by beta-adrenergic blocking agents, such as propranolol and metoprolol.", "output": "<dopamine, effect, beta-adrenergic blocking agents>, <dopamine, effect, propranolol>, <dopamine, effect, metoprolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The peripheral vasoconstriction caused by high doses of dopamine HCl is antagonized by alpha-adrenergic blocking agents.", "output": "<dopamine HCl, effect, alpha-adrenergic blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Butyrophenones (such as haloperidol) and phenothiazines can suppress the dopaminergic renal and mesenteric vasodilation induced with low dose dopamine infusion.", "output": "<Butyrophenones, effect, dopamine>, <haloperidol, effect, dopamine>, <phenothiazines, effect, dopamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclopropane or halogenated hydrocarbon anesthetics increase cardiac autonomic irritability and may sensitize the myocardium to the action of certain intravenously administered catecholamines, such as dopamine.", "output": "<Cyclopropane, effect, catecholamines>, <Cyclopropane, effect, dopamine>, <halogenated hydrocarbon anesthetics, effect, catecholamines>, <halogenated hydrocarbon anesthetics, effect, dopamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, EXTREME CAUTION should be exercised when administering dopamine HCl to patients receiving cyclopropane or halogenated hydrocarbon anesthetics.", "output": "<dopamine HCl, advise, cyclopropane>, <dopamine HCl, advise, halogenated hydrocarbon anesthetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It has been reported that results of studies in animals indicate that dopamine-induced ventricular arrhythmias during anesthesia can be reversed by propranolol.", "output": "<dopamine, effect, propranolol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant use of vasopressors, vasoconstricting agents (such as ergonovine) and some oxytocic drugs may result in severe hypertension.", "output": "<vasopressor, effect, oxytocic drugs>, <ergonovine, effect, oxytocic drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of phenytoin to patients receiving dopamine HCl has been reported to lead to hypotension and bradycardia.", "output": "<phenytoin, effect, dopamine HCl>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is suggested that in patients receiving dopamine HCl, alternatives to phenytoin should be used if anticonvulsant therapy is needed.", "output": "<dopamine HCl, advise, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The results of a study of coadministration of ethambutol (50 mg/kg) with an aluminum hydroxide containing antacid to 13 patients with tuberculosis showed a reduction of mean serum concentrations and urinary excretion of ethambutol of approximately 20% and 13%, respectively, suggesting that the oral absorption of ethambutol may be reduced by these antacid products.", "output": "<ethambutol, mechanism, aluminum hydroxide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended to avoid concurrent administration of ethambutol with aluminum hydroxide containing antacids for at least 4 hours following ethambutol administration.", "output": "<ethambutol, advise, aluminum hydroxide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drug Interactions: The central anticholinergic syndrome can occur when anticholinergic agents such as AKINETON are administered concomitantly with drugs that have secondary anticholinergic actions, e.g., certain narcotic analgesics such as meperidine, the phenothiazines and other antipsychotics, tricyclic antidepressants, certain antiarrhythmics such as the quinidine salts, and antihistamines.", "output": "<anticholinergic, effect, narcotic analgesics>, <anticholinergic, effect, meperidine>, <anticholinergic, effect, phenothiazines>, <anticholinergic, effect, antipsychotics>, <anticholinergic, effect, tricyclic antidepressants>, <anticholinergic, effect, antiarrhythmics>, <anticholinergic, effect, quinidine>, <anticholinergic, effect, antihistamines>, <AKINETON, effect, narcotic analgesics>, <AKINETON, effect, meperidine>, <AKINETON, effect, phenothiazines>, <AKINETON, effect, antipsychotics>, <AKINETON, effect, tricyclic antidepressants>, <AKINETON, effect, antiarrhythmics>, <AKINETON, effect, quinidine>, <AKINETON, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant use of transdermal fentanyl with ritonavir or other potent 3A4 inhibitors such as ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, and nefazadone may result in an increase in fentanyl plasma concentrations.", "output": "<fentanyl, mechanism, ritonavir>, <fentanyl, mechanism, ketoconazole>, <fentanyl, mechanism, itraconazole>, <fentanyl, mechanism, troleandomycin>, <fentanyl, mechanism, clarithromycin>, <fentanyl, mechanism, nelfinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant use of other CYP3A4 inhibitors such as diltiazem and erythromycin with transdermal fentanyl may also result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause serious respiratory depression.", "output": "<diltiazem, mechanism, fentanyl>, <erythromycin, mechanism, fentanyl>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Central Nervous System Depressants: The concomitant use of DURAGESIC  (fentanyl transdermal system) with other central nervous system depressants, including but not limited to other opioids, sedatives, hypnotics, tranquilizers (e.g., benzodiazepines), general anesthetics, phenothiazines, skeletal muscle relaxants, and alcohol, may cause respiratory depression, hypotension, and profound sedation, or potentially result in coma or death.", "output": "<DURAGESIC, effect, central nervous system depressants>, <DURAGESIC, effect, opioids>, <DURAGESIC, effect, sedatives>, <DURAGESIC, effect, hypnotics>, <DURAGESIC, effect, tranquilizers>, <DURAGESIC, effect, benzodiazepines>, <DURAGESIC, effect, anesthetics>, <DURAGESIC, effect, phenothiazines>, <DURAGESIC, effect, skeletal muscle relaxants>, <DURAGESIC, effect, alcohol>, <fentanyl, effect, central nervous system depressants>, <fentanyl, effect, opioids>, <fentanyl, effect, sedatives>, <fentanyl, effect, hypnotics>, <fentanyl, effect, tranquilizers>, <fentanyl, effect, benzodiazepines>, <fentanyl, effect, anesthetics>, <fentanyl, effect, phenothiazines>, <fentanyl, effect, skeletal muscle relaxants>, <fentanyl, effect, alcohol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "MAO Inhibitors: DURAGESIC  is not recommended for use in patients who have received MAOI within 14 days because severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics", "output": "<DURAGESIC, advise, MAOI>, <MAO inhibitors, advise, opioid analgesics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In vitro studies have shown CASODEX can displace coumarin anticoagulants, such as warfarin, from their protein-binding sites.", "output": "<CASODEX, mechanism, coumarin anticoagulant>, <CASODEX, mechanism, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended that if CASODEX is started in patients already receiving coumarin anticoagulants, prothrombin times should be closely monitored and adjustment of the anticoagulant dose may be necessary.", "output": "<CASODEX, advise, coumarin anticoagulants>, <CASODEX, advise, anticoagulant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors, tricyclic antidepressants or phenothiazines may produce severe, prolonged hypotension or hypertension.", "output": "<anesthetic solutions, effect, tricyclic antidepressants>, <anesthetic solutions, effect, phenothiazines>, <epinephrine, effect, monoamine oxidase inhibitors>, <epinephrine, effect, tricyclic antidepressants>, <epinephrine, effect, phenothiazines>, <norepinephrine, effect, monoamine oxidase inhibitors>, <norepinephrine, effect, tricyclic antidepressants>, <norepinephrine, effect, phenothiazines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent administration of vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents.", "output": "<vasopressor drugs, effect, ergot-type oxytocic drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, chloroprocaine should not be used in any condition in which a sulfonamide drug is being employed.", "output": "<chloroprocaine, advise, sulfonamide drug>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticholinergic agents may affect gastrointestinal absorption of various drugs, such as slowly dissolving dosage forms of digoxin;", "output": "<Anticholinergic agents, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticholinergic drugs may antagonize the effects of the drugs that alter gastrointestinal motility, such as metoclopramide.", "output": "<Anticholinergic drugs, mechanism, metoclopramide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because antacids may interfere with the absorption of anticholinergic agents, simultaneous use of these drugs should be avoided.", "output": "<antacids, mechanism, anticholinergic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a study in which patients with active RA were treated for up to 24 weeks with concurrent ENBREL  and anakinra therapy, a 7% rate of serious infections was observed, which was higher than that observed with ENBREL  alone (0%).", "output": "<ENBREL, effect, anakinra>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Two percent of patients treated concurrently with ENBREL  and anakinra developed neutropenia (ANC   1 x 109/L).", "output": "<ENBREL, effect, anakinra>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients in a clinical study who were on established therapy with sulfasalazine, to which ENBREL was added, were noted to develop a mild decrease in mean neutrophil counts in comparison to groups treated with either ENBREL CI or sulfasalazine alone.", "output": "<sulfasalazine, effect, ENBREL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be exercised when administering nabumetone with warfarin since interactions have been seen with other NSAIDs.", "output": "<nabumetone, advise, warfarin>, <warfarin, int, NSAIDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids (aluminum- or magnesium-containing): Concomitant administration of 300-mg cefdinir capsules with 30 mL Maalox TC suspension reduces the rate (Cmax) and extent (AUC) of absorption by approximately 40%.", "output": "<cefdinir, mechanism, Maalox TC>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If antacids are required during OMNICEF therapy, OMNICEF should be taken at least 2 hours before or after the antacid.", "output": "<OMNICEF, advise, antacid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid: As with other b-lactam antibiotics, probenecid inhibits the renal excretion of cefdinir, resulting in an approximate doubling in A.C. a 54% increase in peak cefdinir plasma levels, and a 50% prolongation in the apparent elimination half-life.", "output": "<b-lactam antibiotics, mechanism, cefdinir>, <probenecid, mechanism, cefdinir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Iron Supplements and Foods Fortified With Iron Concomitant administration of cefdinir with a therapeutic iron supplement containing 60 mg of elemental iron (as FeSO4) or vitamins supplemented with 10 mg of elemental iron reduced extent of absorption by 80% and 31%, respectively.", "output": "<cefdinir, mechanism, iron>, <cefdinir, mechanism, iron>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If iron supplements are required during OMNICEF therapy, OMNICEF should be taken at least 2 hours before or after the supplement.", "output": "<iron supplements, advise, OMNICEF>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The reddish color is due to the formation of a nonabsorbable complex between cefdinir or its breakdown products and iron in the gastrointestinal tract.", "output": "<cefdinir, mechanism, iron>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent use of butorphanol with central nervous system depressants (e.g., alcohol, barbiturates, tranquilizers, and antihistamines) may result in increased central nervous system depressant effects.", "output": "<butorphanol, effect, central nervous system depressants>, <butorphanol, effect, alcohol>, <butorphanol, effect, barbiturates>, <butorphanol, effect, tranquilizers>, <butorphanol, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, in another study in healthy volunteers, the pharmacokinetics of butorphanol were significantly altered (29% decrease in AUC and 38% decrease in Cmax) when a 1-mg dose of STADOL NS was administered 1 minute after a 20-mg dose of sumatriptan nasal spray.", "output": "<STADOL NS, mechanism, sumatriptan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When the STADOL NS was administered 30 minutes after the sumatriptan nasal spray, the AUC of butorphanol increased 11% and Cmax decreased 18%.", "output": "<STADOL NS, mechanism, sumatriptan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "These results suggest that the analgesic effect of STADOL NS may be diminished when it is administered shortly after sumatriptan nasal spray, but by 30 minutes any such reduction in effect should be minimal.", "output": "<STADOL NS, effect, sumatriptan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is not known if the effects of butorphanol are altered by concomitant medications that affect hepatic metabolism of drugs (erythromycin, etc.), but physicians should be alert to the possibility that a smaller initial dose and longer intervals between doses may be needed.", "output": "<butorphanol, advise, erythromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, a slower onset can be anticipated if STADOL NS is administered concomitantly with, or immediately following, a nasal vasoconstrictor.", "output": "<STADOL NS, effect, nasal vasoconstrictor>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Hypotension: Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with enalapril or enalaprilat.", "output": "<diuretics, effect, enalapril>, <diuretics, effect, enalaprilat>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The possibility of hypotensive effects with enalapril or enalaprilat can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with enalapril or enalaprilat.", "output": "<enalapril, effect, diuretic>, <enalaprilat, effect, diuretic>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Agents Causing Renin Release: The antihypertensive effect of enalapril and enalapril IV is augmented by antihypertensive agents that cause renin release (e.g., diuretics).", "output": "<enalapril, effect, antihypertensive agents>, <enalapril, effect, diuretics>, <enalapril, effect, antihypertensive agents>, <enalapril, effect, diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Non-steroidal Anti-inflammatory Agents: In some patients with compromised renal function who are being treated with nonsteroidal anti-inflammatory drugs, the co-administration of enalapril may result in a further deterioration of renal function.", "output": "<nonsteroidal anti-inflammatory drugs, effect, enalapril>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors.", "output": "<NSAIDs, effect, ACE inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE inhibitors.", "output": "<NSAIDs, advise, ACE inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Agents Increasing Serum Potassium: Enalapril and enalapril IV attenuate potassium loss caused by thiazide-type diuretics.", "output": "<Enalapril, effect, thiazide-type diuretics>, <enalapril, effect, thiazide-type diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors.", "output": "<lithium, effect, ACE inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended that serum lithium levels be monitored frequently if enalapril is administered concomitantly with lithium.", "output": "<enalapril, advise, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12.", "output": "<Colchicine, mechanism, vitamin B12>, <para-aminosalicylic acid, mechanism, vitamin B12>, <alcohol, mechanism, vitamin B12>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Uricosuric Agents: Aspirin may decrease the effects of probenecid, sulfinpyrazone, and phenylbutazone.", "output": "<Aspirin, effect, probenecid>, <Aspirin, effect, sulfinpyrazone>, <Aspirin, effect, phenylbutazone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Alcohol: Has a synergistic effect with aspirin in causing gastrointestinal bleeding.", "output": "<Alcohol, effect, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticosteroids: Concomitant administration with aspirin may increase the risk of gastrointestinal ulceration and may reduce serum salicylate levels.", "output": "<Corticosteroids, effect, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pyrazolone Derivatives (phenylbutazone, oxyphenbutazone, and possibly dipyrone): Concomitant administration with aspirin may increase the risk of gastrointestinal ulceration.", "output": "<Pyrazolone Derivatives, effect, aspirin>, <phenylbutazone, effect, aspirin>, <oxyphenbutazone, effect, aspirin>, <dipyrone, effect, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nonsteroidal Antiinflammatory Agents: Aspirin is contraindicated in patients who are hypersensitive to nonsteroidal anti-inflammatory agents.", "output": "<Aspirin, advise, nonsteroidal anti-inflammatory>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenobarbital: Decreases aspirin effectiveness by enzyme induction.", "output": "<Phenobarbital, mechanism, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin: Serum phenytoin levels may be increased by aspirin.", "output": "<phenytoin, effect, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Propranolol: May decrease aspirins anti-inflammatory action by competing for the same receptors.", "output": "<Propranolol, effect, aspirins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids: Enteric Coated Aspirin should not be given concurrently with antacids, since an increase in the pH of the stomach may effect the enteric coating of the tablets.", "output": "<Aspirin, advise, antacids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "conversely, diethylpropion may interfere with antihypertensive drugs (i.e., guanethidine, a-methyldopa).", "output": "<diethylpropion, int, antihypertensive drugs>, <diethylpropion, int, guanethidine>, <diethylpropion, int, a-methyldopa>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent use of phenothiazines may antagonize the anorectic effect of diethylpropion.", "output": "<phenothiazines, effect, diethylpropion>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of SPRYCEL and drugs that inhibit CYP3A4 (eg, ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, atazanavir, indinavir, nefazodone, nelfinavir, saquinavir, telithromycin) may increase exposure to dasatinib and should be avoided.", "output": "<SPRYCEL, mechanism, ketoconazole>, <SPRYCEL, mechanism, itraconazole>, <SPRYCEL, mechanism, erythromycin>, <SPRYCEL, mechanism, clarithromycin>, <SPRYCEL, mechanism, ritonavir>, <SPRYCEL, mechanism, atazanavir>, <SPRYCEL, mechanism, indinavir>, <SPRYCEL, mechanism, nefazodone>, <SPRYCEL, mechanism, nelfinavir>, <SPRYCEL, mechanism, saquinavir>, <SPRYCEL, mechanism, telithromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Simultaneous administration of SPRYCEL with antacids should be avoided.", "output": "<SPRYCEL, advise, antacids>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If antacid therapy is needed, the antacid dose should be administered at least 2 hours prior to or 2 hours after the dose of SPRYCEL.", "output": "<antacid, advise, SPRYCEL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "H2 Blockers/Proton Pump Inhibitors: Long-term suppression of gastric acid secretion by H2 blockers or proton pump inhibitors (eg, famotidine and omeprazole) is likely to reduce dasatinib exposure.", "output": "<H2 blockers, effect, dasatinib>, <proton pump inhibitors, effect, dasatinib>, <famotidine, effect, dasatinib>, <omeprazole, effect, dasatinib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant use of H2 blockers or proton pump inhibitors with SPRYCEL is not recommended.", "output": "<H2 blockers, advise, SPRYCEL>, <proton pump inhibitors, advise, SPRYCEL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The use of antacids should be considered in place of H2 blockers or proton pump inhibitors in patients receiving SPRYCEL therapy.", "output": "<H2 blockers, advise, SPRYCEL>, <proton pump inhibitors, advise, SPRYCEL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, CYP3A4 substrates known to have a narrow therapeutic index such as alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ergot alkaloids (ergotamine, dihydroergotamine) should be administered with caution in patients receiving SPRYCEL.", "output": "<alfentanil, advise, SPRYCEL>, <astemizole, advise, SPRYCEL>, <terfenadine, advise, SPRYCEL>, <cisapride, advise, SPRYCEL>, <cyclosporine, advise, SPRYCEL>, <fentanyl, advise, SPRYCEL>, <pimozide, advise, SPRYCEL>, <quinidine, advise, SPRYCEL>, <sirolimus, advise, SPRYCEL>, <tacrolimus, advise, SPRYCEL>, <ergot alkaloids, advise, SPRYCEL>, <ergotamine, advise, SPRYCEL>, <dihydroergotamine, advise, SPRYCEL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "After multiple dosing, interferon beta-1a (AVONEX  30 mcg IM once weekly) reduced TYSABRI  clearance by approximately 30%.", "output": "<interferon beta-1a, mechanism, TYSABRI>, <AVONEX, mechanism, TYSABRI>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of terfenadine with Itraconazole has led to elevated plasma concentrations of terfenadine, resulting in rare instances of life- threatening cardiac dysrhythmias and one death.", "output": "<terfenadine, mechanism, Itraconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Another oral azole antifungal, ketoconazole, inhibits the metabolism of astemizole, resulting in elevated plasma concentrations of astemizole and its active metabolite desmethylastermizole which may prolong QT intervals.", "output": "<ketoconazole, mechanism, astemizole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In vitro data suggest that itraconazole, when compared to ketoconazole, has a less pronounced effect on the biotransformation system responsible for the metabolism of astemizole.", "output": "<itraconazole, mechanism, astemizole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Based on the chemical resemblance of itraconazole and ketoconazole, coadministration of astemizole with itraconazole is contraindicated.", "output": "<astemizole, advise, itraconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Human pharmacokinetics data indicate that oral ketoconazole potently inhibits the metabolism of cisapride resulting in an eight-fold increase in the mean AUC of cisapride.", "output": "<ketoconazole, mechanism, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Data suggest that coadministration of oral ketoconazole and cisapride can result in prolongation of the QT interval on the ECG.", "output": "<ketoconazole, effect, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In vitro data suggest that itraconazole also markedly inhibits the biotransformation system mainly responsible for the metabolism of cisapride;", "output": "<itraconazole, mechanism, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "therefore concomitant administration of Itraconazole with cisapride is contraindicated.", "output": "<Itraconazole, advise, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of Itraconazole with oral midazolam or triazolam has resulted in elevated plasma concentrations of the latter two drugs.", "output": "<Itraconazole, mechanism, midazolam>, <Itraconazole, mechanism, triazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of Itraconazole and cyclosporine, tacrolimus or digoxin has led to increased plasma concentrations of the latter three drugs.", "output": "<Itraconazole, mechanism, cyclosporine>, <Itraconazole, mechanism, tacrolimus>, <Itraconazole, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporine, tacrolimus and digoxin concentrations should be monitored at the initiation of Itraconazole therapy and frequently thereafter, and the dose of these three drug products adjusted appropriately.", "output": "<Cyclosporine, advise, Itraconazole>, <tacrolimus, advise, Itraconazole>, <digoxin, advise, Itraconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rhabdomyolysis has been observed in patients receiving HMG-CoA reductase inhibitors administered alone (at recommended dosages) or concomitantly with immunosuppressive drugs including cyclosporine.", "output": "<HMG-CoA reductase inhibitors, effect, immunosuppressive drugs>, <HMG-CoA reductase inhibitors, effect, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When Itraconazole was coadministered with phenytoin, rifampin, or H2antagonists, reduced plasma concentrations of itraconazole were reported.", "output": "<Itraconazole, mechanism, phenytoin>, <Itraconazole, mechanism, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although no studies have been conducted, concomitant administration of Itraconazole and phenytoin may alter the metabolism of phenytoin;", "output": "<Itraconazole, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "therefore, plasma concentrations of phenytoin should also be monitored when it is given concurrently with Itraconazole.", "output": "<phenytoin, advise, Itraconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It has been reported that Itraconazole enhances the anticoagulant effect of coumarin-like drugs.", "output": "<Itraconazole, effect, coumarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, prothrombin time should be carefully monitored in patients receiving Itraconazole and coumarin-like drugs simultaneously.", "output": "<Itraconazole, advise, coumarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Plasma concentrations of azole antifungal agents are reduced when given concurrently with isoniazid.", "output": "<azole antifungal agents, mechanism, isoniazid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Itraconazole plasma concentrations should be monitored when Itraconazole and isoniazid are coadministered.", "output": "<Itraconazole, advise, isoniazid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Severe hypoglycemia has been reported in patients concomitantly receiving azole antifungal agents and oral hypoglycemic agents.", "output": "<azole antifungal agents, effect, hypoglycemic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Blood glucose concentrations should be carefully monitored when Itraconazole and oral hypoglycemic agents are coadministered.", "output": "<Itraconazole, advise, hypoglycemic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tinnitus and decreased hearing have been reported in patients concomitantly receiving Itraconazole and quinidine.", "output": "<Itraconazole, effect, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Edema has been reported in patients concomitantly receiving Itraconazole and dihydropyridine calcium channel blockers.", "output": "<Itraconazole, effect, dihydropyridine calcium channel blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tetracycline, a bacteriostatic antibiotic, may antagonize the bactercidal effect of penicillin and concurrent use of these drugs should be avoided.", "output": "<Tetracycline, effect, penicillin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antibiotics: In vitro and/or in vivo data show that clarithromycin, erythromycin, and troleandomycin markedly inhibit the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG.", "output": "<clarithromycin, mechanism, cisapride>, <erythromycin, mechanism, cisapride>, <troleandomycin, mechanism, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticholinergics: Concurrent administration of certain anticholinergic compounds, such as belladonna alkaloids and dicyclomine, would be expected to compromise the beneficial effects of cisapride.", "output": "<anticholinergic compounds, effect, cisapride>, <belladonna alkaloids, effect, cisapride>, <dicyclomine, effect, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is advisable to check coagulation time within the first few days after the start and discontinuation of cisapride therapy, with an appropriate adjustment of the anticoagulant dose, if necessary.", "output": "<cisapride, advise, anticoagulant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antidepressants: In vitro data indicate that nefazodone inhibits the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG.", "output": "<nefazodone, mechanism, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antifungals: In vitro and/or in vivo data indicate that fluconazole, itraconazole, and oral ketoconazole markedly inhibit the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG.", "output": "<fluconazole, mechanism, cisapride>, <itraconazole, mechanism, cisapride>, <ketoconazole, mechanism, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Human pharmacokinetic data indicate that oral ketoconazole markedly inhibits the metabolism of cisapride, resulting in a mean eight-fold increase in AUC of cisapride.", "output": "<ketoconazole, mechanism, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A study in 14 normal male and female volunteers suggests that coadministration of cisapride and ketoconazole can result in prolongation of the QT interval on the ECG.", "output": "<cisapride, effect, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "H2 Receptor Antagonists: Cimetidine coadministration leads to an increased peak plasma concentration and AUC of cisapride, there is no effect on cisapride absorption when it is coadministered with ranitidine.", "output": "<Cimetidine, mechanism, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The gastrointestinal absorption of cimetidine and ranitidine is accelerated when they are coadministered with cisapride.", "output": "<cimetidine, mechanism, cisapride>, <ranitidine, mechanism, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Protease Inhibitors: In vitro data indicate that indinavir and ritonavir markedly inhibit the metabolism of cisapride which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG.", "output": "<indinavir, mechanism, cisapride>, <ritonavir, mechanism, cisapride>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cisapride should not be used concomitantly with other drugs known to prolong the QT interval: certain antiarrhythmics, including those of Class IA (such as quinidine and procainamide) and Class III (such as sotalol);", "output": "<Cisapride, advise, antiarrhythmics>, <Cisapride, advise, quinidine>, <Cisapride, advise, procainamide>, <Cisapride, advise, sotalol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chlorotrianisene may interact with antidepressants, aspirin, barbiturates, bromocriptine, calcium supplements, corticosteroids, corticotropin, cyclosporine, dantrolene, nicotine, somatropin, tamoxifen, and warfarin.", "output": "<Chlorotrianisene, int, antidepressants>, <Chlorotrianisene, int, aspirin>, <Chlorotrianisene, int, barbiturates>, <Chlorotrianisene, int, bromocriptine>, <Chlorotrianisene, int, calcium>, <Chlorotrianisene, int, corticosteroids>, <Chlorotrianisene, int, corticotropin>, <Chlorotrianisene, int, cyclosporine>, <Chlorotrianisene, int, dantrolene>, <Chlorotrianisene, int, nicotine>, <Chlorotrianisene, int, somatropin>, <Chlorotrianisene, int, tamoxifen>, <Chlorotrianisene, int, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In combination with other central nervous system depressants, heroin may still kill even experienced users, particularly if their tolerance to the drug has reduced or the strength of their usual dose has increased.", "output": "<central nervous system depressants, effect, heroin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Toxicology studies of heroin-related deaths reveal frequent involvement of other central nervous system depressants, including alcohol, benzodiazepines such as diazepam (Valium), and, to a rising degree, methadone.", "output": "<heroin, effect, central nervous system depressants>, <heroin, effect, alcohol>, <heroin, effect, benzodiazepines>, <heroin, effect, diazepam>, <heroin, effect, Valium>, <heroin, effect, methadone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cocaine sometimes proves to be fatal when used in combination with heroin.", "output": "<Cocaine, effect, heroin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Cholestyramine and colestipol resins: Cholestytamine and colestipol resins have the potential of binding thiazide diuretics and reducing diuretic absorption from the gastrointestinal tract", "output": "<Cholestytamine, mechanism, thiazide diuretics>, <colestipol, mechanism, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Lithium: Generally should not be given with diuretics.", "output": "<Lithium, advise, diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.", "output": "<Diuretic agents, mechanism, lithium>, <Diuretic agents, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Refer to the package insert for lithium preparations before use of such preparations with chlorothiazide", "output": "<lithium, advise, chlorothiazide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "- Non-steroidal Anti-inflammatory Drugs: In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.", "output": "<non-steroidal anti-inflammatory agent, effect, loop diuretics>, <non-steroidal anti-inflammatory agent, effect, potassium-sparing diuretics>, <non-steroidal anti-inflammatory agent, effect, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, when chlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained", "output": "<chlorothiazide, advise, non-steroidal anti-inflammatory agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Renal clearance measurements of PAH cannot be made with any significant accuracy in patients receiving sulfonamides, procaine, or thiazolesulfone.", "output": "<PAH, effect, sulfonamides>, <PAH, effect, procaine>, <PAH, effect, thiazolesulfone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid depresses tubular secretion of certain weak acids such as PAH.", "output": "<Probenecid, mechanism, PAH>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, patients receiving probenecid will have erroneously low ERPF and Tm PAH values.", "output": "<probenecid, effect, PAH>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients on oral antidiabetic agents receiving VELCADE treatment may require close monitoring of their blood glucose levels and adjustment of the dose of their antidiabetic medication.", "output": "<antidiabetic agents, advise, VELCADE>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antihistamines may enhance the effects of tricyclic antidepressants, barbiturates, alcohol, and other CNS depressants.", "output": "<Antihistamines, effect, tricyclic antidepressants>, <Antihistamines, effect, barbiturates>, <Antihistamines, effect, alcohol>, <Antihistamines, effect, CNS depressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines.", "output": "<MAO inhibitors, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sympathomimetic amines may reduce the antihypertensive effects of reserpine, veratrum alkaloids, methyldopa and mecamylamine.", "output": "<Sympathomimetic amines, effect, reserpine>, <Sympathomimetic amines, effect, veratrum alkaloids>, <Sympathomimetic amines, effect, methyldopa>, <Sympathomimetic amines, effect, mecamylamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Effects of sympathomimetics are increased with MAO inhibitors and beta adrenergic blockers.", "output": "<sympathomimetics, effect, MAO inhibitors>, <sympathomimetics, effect, beta adrenergic blockers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because of the danger of a potentially fatal prolongation of the QTc interval, halofantrine must not be given simultaneously with or subsequent to Mefloquine.", "output": "<halofantrine, advise, Mefloquine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of Mefloquine and other related compounds (eg, quinine, quinidine and chloroquine) may produce electrocardiographic abnormalities and increase the risk of convulsions.", "output": "<Mefloquine, effect, quinine>, <Mefloquine, effect, quinidine>, <Mefloquine, effect, chloroquine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This appears to be the only clinically relevant interaction of this kind with Mefloquine, although theoretically, coadministration of other drugs known to alter cardiac conduction (eg, anti-arrhythmic or beta-adrenergic blocking agents, calcium channel blockers, antihistamines or H1-blocking agents, tricyclic antidepressants and phenothiazines) might also contribute to a prolongation of the QTc interval.", "output": "<Mefloquine, effect, anti-arrhythmic>, <Mefloquine, effect, beta-adrenergic blocking agents>, <Mefloquine, effect, calcium channel blockers>, <Mefloquine, effect, antihistamines>, <Mefloquine, effect, H1-blocking agents>, <Mefloquine, effect, tricyclic antidepressants>, <Mefloquine, effect, phenothiazines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients taking an anticonvulsant (eg, valproic acid, carbamazepine, phenobarbital or phenytoin), the concomitant use of Mefloquine may reduce seizure control by lowering the plasma levels of the anticonvulsant.", "output": "<anticonvulsant, effect, Mefloquine>, <valproic acid, effect, Mefloquine>, <carbamazepine, effect, Mefloquine>, <phenobarbital, effect, Mefloquine>, <phenytoin, effect, Mefloquine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When Mefloquine is taken concurrently with oral live typhoid vaccines, attenuation of immunization cannot be excluded.", "output": "<Mefloquine, effect, live typhoid vaccines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nevertheless, the effects of Mefloquine on travelers receiving comedication, particularly diabetics or patients using anticoagulants, should be checked before departure.", "output": "<Mefloquine, advise, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.", "output": "<Lithium, mechanism, diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "EDECRIN may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics.", "output": "<EDECRIN, effect, aminoglycoside>, <EDECRIN, effect, cephalosporin antibiotics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein;", "output": "<ethacrynic acid, mechanism, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In some patients, the administration of a non- steroidal antiinflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium- sparing and thiazide diuretics.", "output": "<non- steroidal antiinflammatory agent, effect, loop diuretics>, <non- steroidal antiinflammatory agent, effect, potassium- sparing diuretics>, <non- steroidal antiinflammatory agent, effect, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, when EDECRIN and non- steroidal anti- inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.", "output": "<EDECRIN, effect, non- steroidal anti- inflammatory agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Non-selective MAO inhibitors including tranylcypromine sulfate, phenelzine sulfate, and pargyline HC1: Concomitant use of L-tyrosine and non-selective MAO inhibitors may cause hypertension.", "output": "<L-tyrosine, effect, MAO inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Based on adult data, lower doses of caffeine may be needed following coadministration of drugs which are reported to decrease caffeine elimination (e.g., cimetidine and ketoconazole) and higher caffeine doses may be needed following coadministration of drugs that increase caffeine elimination (e.g., phenobarbital and phenytoin).", "output": "<caffeine, advise, cimetidine>, <caffeine, advise, ketoconazole>, <caffeine, advise, phenobarbital>, <caffeine, advise, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caffeine administered concurrently with ketoprofen reduced the urine volume in 4 healthy volunteers.", "output": "<Caffeine, effect, ketoprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Auranofin should be avoided by patients with a history of serious reaction to any gold medication, including Solganal and Myochrysine.", "output": "<Auranofin, advise, gold medication>, <Auranofin, advise, Solganal>, <Auranofin, advise, Myochrysine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Auranofin should not be used together with penicillamine (Depen, Cuprimine), another arthritis medication.", "output": "<Auranofin, advise, penicillamine>, <Auranofin, advise, Depen>, <Auranofin, advise, Cuprimine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The in vitro interaction between nevirapine and the antithrombotic agent warfarin is complex.", "output": "<nevirapine, int, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When warfarin is co-administered with nevirapine, anticoagulation levels should be monitored frequently.", "output": "<warfarin, advise, nevirapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Clarithromycin exposure was significantly decreased by nevirapine;", "output": "<Clarithromycin, mechanism, nevirapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oral contraceptives and other hormonalmethods of birth control should not be usedas the sole method of contraception inwomen taking nevirapine, since nevirapinemay lower the plasma levels of thesemedications.", "output": "<contraceptives, advise, nevirapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nevirapine and ketoconazole should not beadministered concomitantly becausedecreases in ketoconazole plasmaconcentrations may reduce the efficacy of the drug.", "output": "<Nevirapine, advise, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A dose increase of lopinavir/ritonavir to 533/133 mg twice daily with food isrecommended in combination with nevirapine.", "output": "<lopinavir, advise, nevirapine>, <ritonavir, advise, nevirapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methadone levels may be decreased; increased dosages may be required to prevent symptoms of opiate withdrawal. Methadone maintained patients beginning nevirapine therapy should be monitored forevidence of withdrawal and methadone dose should be adjusted accordingly.", "output": "<Methadone, advise, nevirapine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nevirapine and rifampin should not beadministered concomitantly becausedecreases in nevirapine plasmaconcentrations may reduce the efficacy ofthe drug.", "output": "<Nevirapine, advise, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "aBased on reports of narcotic withdrawal syndrome in patients treated with nevirapine and methadone concurrently, and evidence of decreased plasma concentrations of methadone.", "output": "<nevirapine, effect, methadone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: In healthy subjects receiving ketoconazole, a CYP3A4 inhibitor, at 200 mg twice daily for 7 days, systemic exposure (AUC) to lapatinib was increased to approximately 3.6-fold of control and half-life increased to 1.7-fold of control.", "output": "<ketoconazole, mechanism, lapatinib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Carbamazepine: In healthy subjects receiving the CYP3A4 inducer, carbamazepine, at 100 mg twice daily for 3 days and 200 mg twice daily for 17 days, systemic exposure (AUC) to lapatinib was decreased approximately 72%.", "output": "<carbamazepine, mechanism, lapatinib>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "MAO inhibitors should be used with caution in patients receiving hydralazine.", "output": "<MAO inhibitors, advise, hydralazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When other potent parental antihypertensive drugs, such as diazoxide, are used in combination with hydralazine, patients should be continuously observed for several hours for any excessive fall in blood pressure.", "output": "<antihypertensive drugs, effect, diazoxide>, <antihypertensive drugs, effect, hydralazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Profound hypotensive episodes may occur when diazoxide infection and hydralazine are used concomitantly.", "output": "<diazoxide, effect, hydralazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Propranolol increases hydralazines serum concentrations.", "output": "<Propranolol, mechanism, hydralazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "NSAIDs may decrease the hemodynamic effects of hydralazine;", "output": "<NSAIDs, effect, hydralazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, because bleeding has been reported when ibuprofen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen to patients on anticoagulants.", "output": "<ibuprofen, effect, coumarin-type anticoagulants>, <nonsteroidal anti-inflammatory agents, effect, coumarin-type anticoagulants>, <ibuprofen, advise, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including ibuprofen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug.", "output": "<aspirin, effect, nonsteroidal anti-inflammatory agents>, <aspirin, effect, ibuprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methotrexate: Ibuprofen, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices.", "output": "<Ibuprofen, mechanism, methotrexate>, <nonsteroidal anti-inflammatory drugs, mechanism, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "This may indicate that ibuprofen could enhance the toxicity of methotrexate.", "output": "<ibuprofen, effect, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be used if ibuprofen is administered concomitantly with methotrexate.", "output": "<ibuprofen, advise, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Furosemide: Clinical studies, as well as random observations, have shown that ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients.", "output": "<ibuprofen, effect, furosemide>, <ibuprofen, effect, thiazides>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: Ibuprofen produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers.", "output": "<Ibuprofen, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.", "output": "<ibuprofen, advise, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Carbamazepine: Elevated carbamazepine levels have been reported in postmarketing experience when SUPRAX is administered concomitantly.", "output": "<carbamazepine, mechanism, SUPRAX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin and Anticoagulants: Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly.", "output": "<Warfarin, effect, cefixime>, <Anticoagulants, effect, cefixime>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine: Cimetidine increases nicardipine HCl plasma levels.", "output": "<Cimetidine, mechanism, nicardipine HCl>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digoxin: Some calcium blockers may increase the concentration of digitalis preparations in the blood.", "output": "<calcium blockers, mechanism, digitalis preparations>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nicardipine HCl usually does not alter the plasma levels of digoxin, however, serum digoxin levels should be evaluated after concomitant therapy with nicardipine HCl is initiated.", "output": "<digoxin, advise, nicardipine HCl>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Plasma concentrations of cyclosporine should therefore be closely monitored, and its dosage reduced accordingly, in patients treated with nicardipine.", "output": "<cyclosporine, advise, nicardipine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients treated with proton pump inhibitors and warfarin concomitantly may need to be monitored for increases in INR and prothrombin time.", "output": "<proton pump inhibitors, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of esomeprazole 30 mg and diazepam, a CYP2C19 substrate, resulted in a 45% decrease in clearance of diazepam.", "output": "<esomeprazole, mechanism, diazepam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg, ketoconazole, iron salts and digoxin).", "output": "<esomeprazole, mechanism, ketoconazole>, <esomeprazole, mechanism, iron>, <esomeprazole, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant administration of clarithromycin with pimozide is contraindicated.", "output": "<clarithromycin, advise, pimozide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aspirin: Concomitant administration of diclofenac and aspirin is not recommended because diclofenac is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels, and AUC values.", "output": "<diclofenac, advise, aspirin>, <diclofenac, mechanism, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anticoagulants: While studies have not shown diclofenac to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs.", "output": "<diclofenac, advise, NSAIDs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because prostaglandins play an important role in hemostasis, and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including diclofenac, and warfarin requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.", "output": "<NSAIDs, advise, warfarin>, <diclofenac, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ingestion of diclofenac may increase serum concentrations of digoxin and methotrexate and increase cyclosporine s nephrotoxicity.", "output": "<diclofenac, mechanism, digoxin>, <diclofenac, mechanism, methotrexate>, <diclofenac, effect, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients who begin taking diclofenac or who increase their diclofenac dose or any other NSAID while taking digoxin, methotrexate, or cyclosporine may develop toxicity characteristics for these drugs.", "output": "<diclofenac, effect, digoxin>, <diclofenac, effect, methotrexate>, <diclofenac, effect, cyclosporine>, <NSAID, effect, digoxin>, <NSAID, effect, methotrexate>, <NSAID, effect, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lithium: Diclofenac decreases lithium renal clearance and increases lithium plasma levels.", "output": "<Diclofenac, mechanism, lithium>, <Diclofenac, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients taking diclofenac and lithium concomitantly, lithium toxicity may develop.", "output": "<diclofenac, effect, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of diclofenac that necessitated changes in the doses of such agents.", "output": "<insulin, effect, diclofenac>, <hypoglycemic agents, effect, diclofenac>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A direct causal relationship has not been established, but physicians should consider the possibility that diclofenac may alter a diabetic patient s response to insulin or oral hypoglycemic agents.", "output": "<diclofenac, effect, insulin>, <diclofenac, effect, hypoglycemic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diuretics: Diclofenac and other NSAIDs can inhibit the activity of diuretics.", "output": "<Diclofenac, effect, diuretics>, <NSAIDs, effect, diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of diclofenac therapy.", "output": "<phenobarbital, effect, diclofenac>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Protein Binding In vitro, diclofenac interferes minimally or not at all with the protein binding of salicylic acid (20% decrease in binding), tolbutamide, prednisolone (10% decrease in binding), or warfarin.", "output": "<diclofenac, mechanism, salicylic acid>, <diclofenac, mechanism, tolbutamide>, <diclofenac, mechanism, prednisolone>, <diclofenac, mechanism, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Renal function should be monitored carefully if high doses of aminoglycosides are to be administered with MAXIPIME because of the increased potential of nephrotoxicity and ototoxicity of aminoglycoside antibiotics.", "output": "<aminoglycosides, advise, MAXIPIME>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nephrotoxicity has been reported following concomitant administration of other cephalosporins with potent diuretics such as furosemide.", "output": "<cephalosporins, effect, diuretics>, <cephalosporins, effect, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Potassium-depleting diuretics are a major contributing factor to digitalis toxicity.", "output": "<Potassium-depleting diuretics, effect, digitalis>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, and spironolactone raise the serum digoxin concentration due to a reduction in clearance and/or in volume of distribution of the drug, with the implication that digitalis intoxication may result.", "output": "<Quinidine, mechanism, digoxin>, <verapamil, mechanism, digoxin>, <amiodarone, mechanism, digoxin>, <propafenone, mechanism, digoxin>, <indomethacin, mechanism, digoxin>, <itraconazole, mechanism, digoxin>, <alprazolam, mechanism, digoxin>, <spironolactone, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Erythromycin and clarithromycin (and possibly other macrolide antibiotics) and tetracycline may increase digoxin absorption in patients who inactivate digoxin by bacterial metabolism in the lower intestine, so that digitalis intoxication may result.", "output": "<Erythromycin, mechanism, digoxin>, <clarithromycin, mechanism, digoxin>, <macrolide antibiotics, mechanism, digoxin>, <tetracycline, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Propantheline and diphenoxylate, by decreasing gut motility, may increase digoxin absorption.", "output": "<Propantheline, mechanism, digoxin>, <diphenoxylate, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids, kaolin-pectin, sulfasalazine, neomycin, cholestyramine, certain anticancer drugs, and metoclopramide may interfere with intestinal digoxin absorption, resulting in unexpectedly low serum concentrations.", "output": "<Antacids, mechanism, digoxin>, <kaolin, mechanism, digoxin>, <sulfasalazine, mechanism, digoxin>, <neomycin, mechanism, digoxin>, <cholestyramine, mechanism, digoxin>, <metoclopramide, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rifampin may decrease serum digoxin concentration, especially in patients with renal dysfunction, by increasing the non-renal clearance of digoxin.", "output": "<Rifampin, mechanism, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thyroid administration to a digitalized, hypothyroid patient may increase the dose requirement of digoxin.", "output": "<Thyroid, advise, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concomitant use of digoxin and sympathomimetics increases the risk of cardiac arrhythmias.", "output": "<digoxin, effect, sympathomimetics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although beta-adrenergic blockers or calcium channel blockers and digoxin may be useful in combination to control atrial fibrillation, their additive effects on AV node conduction can result in advanced or complete heart block.", "output": "<beta-adrenergic blockers, effect, digoxin>, <calcium channel blockers, effect, digoxin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In a multiple dose study of theophylline (400 mg once daily for 3 days) and cetirizine (20 mg once daily for 3 days), a 16% decrease in the clearance of cetirizine was observed.", "output": "<theophylline, mechanism, cetirizine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There was a small decrease in the clearance of cetirizine caused by a 400-mg dose of theophylline;", "output": "<cetirizine, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Preliminary data which suggest that dapsone may inhibit the anti-inflammatory activity of Lamprene have not been confirmed.", "output": "<dapsone, effect, Lamprene>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If leprosy-associated inflammatory reactions develop in patients being treated with dapsone and clofazimine, it is still advisable to continue treatment with both drugs.", "output": "<dapsone, advise, clofazimine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenothiazines - Taking piperazine and a phenothiazine together may increase the risk of convulsions (seizures).", "output": "<piperazine, effect, phenothiazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pyrantel (e.g., Antiminth) - Taking piperazine and pyrantel together may decrease the effects of piperazine.", "output": "<piperazine, effect, pyrantel>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diphenhydramine hydrochloride has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc).", "output": "<Diphenhydramine hydrochloride, effect, alcohol>, <Diphenhydramine hydrochloride, effect, CNS depressants>, <Diphenhydramine hydrochloride, effect, hypnotics>, <Diphenhydramine hydrochloride, effect, sedatives>, <Diphenhydramine hydrochloride, effect, tranquilizers>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines.", "output": "<MAO inhibitors, effect, antihistamines>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be exercised when anticoagulants are given in conjunction with Atromid-S.", "output": "<anticoagulants, advise, Atromid-S>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Atromid-S may displace acidic drugs such as phenytoin or tolbutamide from their binding sites.", "output": "<Atromid-S, mechanism, phenytoin>, <Atromid-S, mechanism, tolbutamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The hypoglycemic effect of tolbutamide has been reported to increase when Atromid-S is given concurrently.", "output": "<tolbutamide, effect, Atromid-S>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Fulminant rhabdomyolysis has been seen as early as three weeks after initiation of combined therapy with another fibrate and lovastatin but may be seen after several months.", "output": "<fibrate, effect, lovastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "For these reasons, it is felt that, in most subjects who have had an unsatisfactory lipid response to either drug alone, the possible benefits of combined therapy with lovastatin and a fibrate do not outweigh the risks of severe myopathy, rhabdomyolysis, and acute renal failure.", "output": "<lovastatin, effect, fibrate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, the combined use of lovastatin with fibrates should generally be avoided.", "output": "<lovastatin, advise, fibrates>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Treatment with PEGASYS once weekly for 4 weeks in healthy subjects was associated with an inhibition of P450 1A2 and a 25% increase in theophylline AUC.", "output": "<PEGASYS, mechanism, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Theophylline serum levels should be monitored and appropriate dose adjustments considered for patients given both theophylline and PEGASYS.", "output": "<theophylline, advise, PEGASYS>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nucleoside Analogues Didanosine Co-administration of COPEGUS and didanosine is not recommended.", "output": "<COPEGUS, advise, didanosine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Stavudine and Zidovudine Ribavirin can antagonize the in vitro antiviral activity of stavudine and zidovudine against HIV.", "output": "<Ribavirin, effect, stavudine>, <Ribavirin, effect, zidovudine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The adverse effects of CAMPTOSAR, such as myelosuppression and diarrhea, would be expected to be exacerbated by other antineoplastic agents having similar adverse effects.", "output": "<CAMPTOSAR, effect, antineoplastic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Lymphocytopenia has been reported in patients receiving CAMPTOSAR, and it is possible that the administration of dexamethasone as antiemetic prophylaxis may have enhanced the likelihood of this effect.", "output": "<CAMPTOSAR, effect, dexamethasone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The incidence of akathisia in clinical trials of the weekly dosage schedule was greater (8.5%, 4/47 patients) when prochlorperazine was administered on the same day as CAMPTOSAR than when these drugs were given on separate days (1.3%, 1/80 patients).", "output": "<prochlorperazine, effect, CAMPTOSAR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It would be expected that laxative use during therapy with CAMPTOSAR would worsen the incidence or severity of diarrhea, but this has not been studied.", "output": "<laxative, effect, CAMPTOSAR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In view of the potential risk of dehydration secondary to vomiting and/or diarrhea induced by CAMPTOSAR, the physician may wish to withhold diuretics during dosing with CAMPTOSAR and, certainly, during periods of active vomiting or diarrhea.", "output": "<diuretics, effect, CAMPTOSAR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent administration of etanercept (another TNF -blocking agent) and anakinra (an interleukin-1 antagonist) has been associated with an increased risk of serious infections, and increased risk of neutropenia and no additional benefit compared to these medicinal products alone.", "output": "<etanercept, effect, anakinra>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other TNFa-blocking agents (including REMICADE) used in combination with anakinra may also result in similar toxicities.", "output": "<TNFa-blocking agents, effect, anakinra>, <REMICADE, effect, anakinra>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although acid-base and electrolyte disturbances were not reported in the clinical trials with dorzolamide, these disturbances have been reported with oral carbonic anhydrase inhibitors and have, in some instances, resulted in drug interactions (e.g., toxicity associated with high-dose salicylate therapy).", "output": "<dorzolamide, effect, carbonic anhydrase inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Mercaptopurine/Azathioprine: Allopurinol inhibits the enzymatic oxidation of mercaptopurine and azathioprine to 6-thiouric acid.", "output": "<Allopurinol, mechanism, mercaptopurine>, <Allopurinol, mechanism, azathioprine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients receiving mercaptopurine (Purinethol) or azathioprine (Imuran), the concomitant administration of 300-600 mg of allopurinol per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine.", "output": "<allopurinol, advise, mercaptopurine>, <allopurinol, advise, azathioprine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dicumarol: It has been reported that allopurinol prolongs the half-life of the anticoagulant, dicumarol.", "output": "<allopurinol, mechanism, dicumarol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Uricosuric Agents: Since the excretion of oxipurinol is similar to that of urate, uricosuric agents, which increase the excretion of urate, are also likely to increase the excretion of oxipurinol and thus lower the degree of inhibition of xanthine oxidase.", "output": "<uricosuric agents, mechanism, oxipurinol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant administration of uricosuric agents and allopurinol has been associated with a decrease in the excretion of oxypurines (hypoxanthine and xanthine) and an increase in urinary uric acid excretion compared with that observed with allopurinol alone.", "output": "<uricosuric agents, mechanism, allopurinol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Thiazide Diuretics: The reports that the concomitant use of allopurinol and thiazide diuretics may contribute to the enhancement of allopurinol toxicity in some patients have been reviewed in an attempt to establish a cause-and-effect relationship and a mechanism of causation.", "output": "<allopurinol, effect, thiazide diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although a causal mechanism and a cause-and-effect relationship have not been established, current evidence suggests that renal function should be monitored in patients on thiazide diuretics and allopurinol even in the absence of renal failure, and dosage levels should be even more conservatively adjusted in those patients on such combined therapy if diminished renal function is detected..", "output": "<thiazide diuretics, advise, allopurinol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ampicillin/Amoxicillin: An increase in the frequency of skin rash has been reported among patients receiving ampicillin or amoxicillin concurrently with allopurinol compared to patients who are not receiving both drugs.", "output": "<ampicillin, effect, allopurinol>, <amoxicillin, effect, allopurinol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cytotoxic Agents: Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic disease, except leukemia, in the presence of allopurinol.", "output": "<cyclophosphamide, effect, allopurinol>, <cytotoxic agents, effect, allopurinol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chlorpropamide: Chlorpropamides plasma half-life may be prolonged by allopurinol, since allopurinol and chlorpropamide may compete for excretion in the renal tubule.", "output": "<Chlorpropamide, mechanism, allopurinol>, <allopurinol, mechanism, chlorpropamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The risk of hypoglycemia secondary to this mechanism may be increased if allopurinol and chlorpropamide are given concomitantly in the presence of renal insufficiency.", "output": "<allopurinol, effect, chlorpropamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporin: Reports indicate that cyclosporine levels may be increased during concomitant treatment with allopurinol sodium for injection.", "output": "<cyclosporine, mechanism, allopurinol sodium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Catecholamine-depleting drugs, such as reserpine, may have an additive effect when given with beta-blocking agents.", "output": "<Catecholamine-depleting drugs, effect, beta-blocking agents>, <reserpine, effect, beta-blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients treated with acebutolol plus catecholamine depletors should, therefore, be observed closely for evidence of marked bradycardia or hypotension which may present as vertigo, syncope/presyncope, or orthostatic changes in blood pressure without compensatory tachycardia.", "output": "<acebutolol, advise, catecholamine depletors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Exaggerated hypertensive responses have been reported from the combined use of beta-adrenergic antagonists and alpha-adrenergic stimulants, including those contained in proprietary cold remedies and vasoconstrictive nasal drops.", "output": "<beta-adrenergic antagonists, effect, alpha-adrenergic stimulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by nonsteroidal anti-inflammatory drugs has been reported.", "output": "<beta-adrenoceptor blocking agents, effect, nonsteroidal anti-inflammatory drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "These antibiotics should be used in the myasthenic patient only where definitely indicated, and then careful adjustment should be made of adjunctive anticholinesterase dosage.", "output": "<antibiotics, advise, anticholinesterase>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Betaseron administration to three cancer patients over a dose range of 0.025 mg to 2.2 mg led to a dose-dependent inhibition of antipyrine elimination.14 The effect of alternate-day administration of 0.25 mg of Betaseron on drug metabolism in MS patients is unknown.", "output": "<Betaseron, mechanism, antipyrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aminoglycosides: The mixing of piperacillin with an aminoglycoside in vitro can result in substantial inactivation of the aminoglycoside.", "output": "<piperacillin, effect, aminoglycoside>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Vecuronium: When used in the perioperative period, piperacillin has been implicated in the prolongation of the neuromuscular blockade of vecuronium.", "output": "<piperacillin, effect, vecuronium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In one controlled clinical study, the ureidopenicillins, including piperacillin, were reported to prolong the action of vecuronium.", "output": "<piperacillin, effect, vecuronium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Due to their similar mechanism of action, it is expected that the neuromuscular blockade produced by any of the non-depolarizing muscle relaxants could be prolonged in the presence of piperacillin.", "output": "<non-depolarizing muscle relaxants, effect, piperacillin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid: The oral combination of probenecid before intramuscular injection of PIPRACIL produces an increase in piperacillin peak serum level of about 30%.", "output": "<probenecid, mechanism, PIPRACIL>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Methotrexate: Piperacillin sodium may reduce the excretion of methotrexate.", "output": "<Piperacillin sodium, mechanism, methotrexate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Beta-blockers, clonidine, lithium salts, and alcohol may either potentiate or weaken the blood-glucose-lowering effect of insulin.", "output": "<Beta-blockers, effect, insulin>, <clonidine, effect, insulin>, <lithium, effect, insulin>, <alcohol, effect, insulin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The action of the benzodiazepines may be potentiated by anticonvulsants, antihistamines, alcohol, barbiturates, monoamine oxidase inhibitors, narcotics, phenothiazines, psychotropic medications, or other drugs that produce CNS depression.", "output": "<benzodiazepines, effect, anticonvulsants>, <benzodiazepines, effect, antihistamines>, <benzodiazepines, effect, alcohol>, <benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, monoamine oxidase inhibitors>, <benzodiazepines, effect, narcotics>, <benzodiazepines, effect, phenothiazines>, <benzodiazepines, effect, psychotropic medications>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "While no in vivo drug-drug interaction studies were conducted between estazolam and inducers of CYP3A, compounds that are potent CYP3A inducers (such as carbamazepine, phenytoin, rifampin, and barbiturates) would be expected to decrease estazolam concentrations.", "output": "<estazolam, mechanism, carbamazepine>, <estazolam, mechanism, phenytoin>, <estazolam, mechanism, rifampin>, <estazolam, mechanism, barbiturates>, <estazolam, mechanism, estazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Consequently, estazolam should be avoided in patients receiving ketoconazole and itraconazole, which are very potent inhibitors of CYP3A.", "output": "<estazolam, advise, ketoconazole>, <estazolam, advise, itraconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The following are examples of drugs known to inhibit the metabolism of other related benzodiazepines, presumably through inhibition of CYP3A: nefazodone, fluvoxamine, cimetidine, diltiazem, isoniazide, and some macrolide antibiotics.", "output": "<benzodiazepines, mechanism, nefazodone>, <benzodiazepines, mechanism, fluvoxamine>, <benzodiazepines, mechanism, cimetidine>, <benzodiazepines, mechanism, diltiazem>, <benzodiazepines, mechanism, isoniazide>, <benzodiazepines, mechanism, macrolide antibiotics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ethopropazine may interact with alcohol or other CNS depressants, causing increased sedative effects.", "output": "<Ethopropazine, effect, alcohol>, <Ethopropazine, effect, CNS depressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ethopropazine can interact with chlorpromazine, increasing the metabolism of chlorpromazine.", "output": "<Ethopropazine, mechanism, chlorpromazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Catecholamine-depleting drugs, e.g., reserpine, may have an additive effect when given with beta blocking agents.", "output": "<reserpine, effect, beta blocking agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "BREVIBLOC concentrations were equivocally higher when given with warfarin, but this is not likely to be clinically important.", "output": "<BREVIBLOC, mechanism, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When digoxin and BREVIBLOC were concomitantly administered intravenously to normal volunteers, there was a 10-20% increase in digoxin blood levels at some time points.", "output": "<digoxin, mechanism, BREVIBLOC>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When intravenous morphine and BREVIBLOC were concomitantly administered in normal subjects, no effect on morphine blood levels was seen, but BREVIBLOC steady-state blood levels were increased by 46% in the presence of morphine.", "output": "<BREVIBLOC, mechanism, morphine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The onset of neuromuscular blockade by succinylcholine was unaffected by BREVIBLOC, but the duration of neuromuscular blockade was prolonged from 5 minutes to 8 minutes.", "output": "<succinylcholine, effect, BREVIBLOC>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although the interactions observed in these studies do not appear to be of major clinical importance, BREVIBLOC should be titrated with caution in patients being treated concurrently with digoxin, morphine, succinylcholine or warfarin.", "output": "<BREVIBLOC, advise, digoxin>, <BREVIBLOC, advise, morphine>, <BREVIBLOC, advise, succinylcholine>, <BREVIBLOC, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution should be exercised when considering the use of BREVIBLOC and verapamil in patients with depressed myocardial function.", "output": "<BREVIBLOC, advise, verapamil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Additionally, BREVIBLOC should not be used to control supraventricular tachycardia in the presence of agents which are vasoconstrictive and inotropic such as dopamine, epinephrine, and norepinephrine because of the danger of blocking cardiac contractility when systemic vascular resistance is high.", "output": "<BREVIBLOC, advise, dopamine>, <BREVIBLOC, advise, epinephrine>, <BREVIBLOC, advise, norepinephrine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Drug-Drug Interactions Albuterol - STRATTERA should be administered with caution to patients being treated with systemically-administered (oral or intravenous) albuterol (or other beta2 agonists) because the action of albuterol on the cardiovascular system can be potentiated resulting in increases in heart rate and blood pressure.", "output": "<STRATTERA, advise, albuterol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dosage adjustment of STRATTERA may be necessary when coadministered with CYP2D6 inhibitors, e.g., paroxetine, fluoxetine, and quinidine.", "output": "<STRATTERA, advise, paroxetine>, <STRATTERA, advise, fluoxetine>, <STRATTERA, advise, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In EM individuals treated with paroxetine or fluoxetine, the AUC of atomoxetine is approximately 6- to 8-fold and Css,max is about 3- to 4-fold greater than atomoxetine alone.", "output": "<paroxetine, mechanism, atomoxetine>, <fluoxetine, mechanism, atomoxetine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Possible drug interactions of HUMORSOL with succinylcholine or with other anticholinesterase agents.", "output": "<HUMORSOL, int, succinylcholine>, <HUMORSOL, int, anticholinesterase agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When you are using idoxuridine, it is especially important that your health care professional know if you are using the following: Eye product containing boric acid.", "output": "<idoxuridine, advise, boric acid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Boric acid may interact with the idoxuridine preparation causing a gritty substance to form or may interact with the preservative in the idoxuridine preparation causing a toxic effect in the eye.", "output": "<Boric acid, mechanism, idoxuridine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of nelfinavir at steady-state with a single dose of azithromycin (2 x 600 mg tablets) results in increased azithromycin serum concentrations.", "output": "<nelfinavir, effect, azithromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although a dose adjustment of azithromycin is not recommended when administered in combination with nelfinavir, close monitoring for known side effects of azithromycin, such as liver enzyme abnormalities and hearing impairment, is warranted.", "output": "<azithromycin, advise, nelfinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, prudent medical practice dictates careful monitoring of prothrombin time in all patients treated with azithromycin and warfarin concomitantly.", "output": "<azithromycin, advise, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent use of macrolides and warfarin in clinical practice has been associated with increased anticoagulant effects.", "output": "<macrolides, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When used in therapeutic doses, azithromycin had a modest effect on the pharmacokinetics of atorvastatin, carbamazepine, cetirizine, didanosine, efavirenz, fluconazole, indinavir, midazolam, rifabutin, sildenafil, theophylline (intravenous and oral), triazolam, trimethoprim/sulfamethoxazole or zidovudine.", "output": "<azithromycin, mechanism, atorvastatin>, <azithromycin, mechanism, carbamazepine>, <azithromycin, mechanism, cetirizine>, <azithromycin, mechanism, didanosine>, <azithromycin, mechanism, efavirenz>, <azithromycin, mechanism, fluconazole>, <azithromycin, mechanism, indinavir>, <azithromycin, mechanism, midazolam>, <azithromycin, mechanism, rifabutin>, <azithromycin, mechanism, sildenafil>, <azithromycin, mechanism, theophylline>, <azithromycin, mechanism, triazolam>, <azithromycin, mechanism, trimethoprim>, <azithromycin, mechanism, sulfamethoxazole>, <azithromycin, mechanism, zidovudine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration with efavirenz or fluconazole had a modest effect on the pharmacokinetics of azithromycin.", "output": "<efavirenz, mechanism, azithromycin>, <fluconazole, mechanism, azithromycin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Co-administration of probenecid with acyclovir has been shown to increase the mean half-life and the area under the concentration-time curve.", "output": "<probenecid, mechanism, acyclovir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rifampin, an inducer of drug metabolism, decreased the concentrations of losartan and its active metabolite.", "output": "<Rifampin, mechanism, losartan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Fluconazole, an inhibitor of P450 2C9, decreased active metabolite concentration and increased losartan concentration.", "output": "<Fluconazole, mechanism, losartan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "As with other antihypertensive agents, the antihypertensive effect of losartan may be blunted by the non-steroidal anti-inflammatory drug indomethacin", "output": "<losartan, effect, indomethacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators.", "output": "<isosorbide mononitrate, effect, vasodilators>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination.", "output": "<calcium channel blockers, effect, organic nitrates>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels.", "output": "<Probenecid, mechanism, cephalosporins>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Levothyroxine Sodium Absorption: The following agents may bind and decrease absorption of levothyroxine sodium from the gastrointestinal tract: aluminum hydoxide, cholestyramine resin, colestipol hydrochloride, ferrous sulfate, sodium polystyrene sulfonate, soybean flour (e.g., infant formula), sucralfate.", "output": "<levothyroxine sodium, mechanism, aluminum hydoxide>, <levothyroxine sodium, mechanism, cholestyramine>, <levothyroxine sodium, mechanism, colestipol hydrochloride>, <levothyroxine sodium, mechanism, ferrous sulfate>, <levothyroxine sodium, mechanism, sodium polystyrene sulfonate>, <levothyroxine sodium, mechanism, sucralfate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Binding to Serum Proteins: The following agents may either inhibit levothyroxine sodium binding to serum proteins or alter the concentrations of serum binding proteins: androgens and related anabolic hormones, asparaginase, clofibrate, estrogens and estrogen-containing compounds, 5-fluorouracil, furosemide, glucocorticoids, meclofenamic acid, mefenamic acid, methadone, perphenazine, phenylbutazone, phenytoin, salicylates, tamoxifen.", "output": "<levothyroxine sodium, mechanism, androgens>, <levothyroxine sodium, mechanism, anabolic hormones>, <levothyroxine sodium, mechanism, asparaginase>, <levothyroxine sodium, mechanism, clofibrate>, <levothyroxine sodium, mechanism, estrogens>, <levothyroxine sodium, mechanism, estrogen-containing compounds>, <levothyroxine sodium, mechanism, 5-fluorouracil>, <levothyroxine sodium, mechanism, furosemide>, <levothyroxine sodium, mechanism, glucocorticoids>, <levothyroxine sodium, mechanism, meclofenamic acid>, <levothyroxine sodium, mechanism, mefenamic acid>, <levothyroxine sodium, mechanism, methadone>, <levothyroxine sodium, mechanism, perphenazine>, <levothyroxine sodium, mechanism, phenylbutazone>, <levothyroxine sodium, mechanism, phenytoin>, <levothyroxine sodium, mechanism, salicylates>, <levothyroxine sodium, mechanism, tamoxifen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketamine: Marked hypertension and tachycardia have been reported in association with concomitant administration of levothyroxine sodium and ketamine.", "output": "<levothyroxine sodium, effect, ketamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids and sucralfate: Sucralfate and antacids containing magnesium or aluminum, as well as formulations containing divalent and trivalent cations such as Videx  (didanosine), chewable/buffered tablets or the pediatric powder for oral solution can form chelation complexes with lomefloxacin and interfere with its bioavailability.", "output": "<Sucralfate, mechanism, lomefloxacin>, <magnesium, mechanism, lomefloxacin>, <aluminum, mechanism, lomefloxacin>, <Videx, mechanism, lomefloxacin>, <didanosine, mechanism, lomefloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Sucralfate administered 2 hours before lomefloxacin resulted in a slower absorption (mean C max decreased by 30% and mean T max increased by 1 hour) and a lesser extent of absorption (mean AUC decreased by approximately 25%).", "output": "<Sucralfate, mechanism, lomefloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Magnesium- and aluminum-containing antacids, administered concomitantly with lomefloxacin, significantly decreased the bioavailability (48%) of lomefloxacin.", "output": "<Magnesium, mechanism, lomefloxacin>, <aluminum, mechanism, lomefloxacin>, <antacids, mechanism, lomefloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Separating the doses of antacid and lomefloxacin minimizes this decrease in bioavailability;", "output": "<antacid, mechanism, lomefloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other quinolones have demonstrated moderate to marked interference with the metabolism of caffeine, resulting in a reduced clearance, a prolongation of plasma half-life, and an increase in symptoms that accompany high levels of caffeine.", "output": "<quinolones, mechanism, caffeine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine: Cimetidine has been demonstrated to interfere with the elimination of other quinolones.", "output": "<Cimetidine, mechanism, quinolones>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporine: Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with other members of the quinolone class.", "output": "<cyclosporine, mechanism, quinolone class>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Warfarin: Quinolones may enhance the effects of the oral anticoagulant, warfarin, or its derivatives.", "output": "<Quinolones, effect, anticoagulant>, <Quinolones, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aprepitant has been shown to induce the metabolism of S(-) warfarin and tolbutamide, which are metabolized through CYP2C9.", "output": "<Aprepitant, mechanism, S(-) warfarin>, <Aprepitant, mechanism, tolbutamide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Coadministration of Aprepitant with these drugs or other drugs that are known to be metabolized by CYP2C9, such as phenytoin, may result in lower plasma concentrations of these drugs.", "output": "<Aprepitant, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Corticosteroids: Dexamethasone: Aprepitant, when given as a regimen of 125mg with dexamethasone coadministered orally as 20 mg on Day 1, and Aprepitant when given as 80 mg/day with dexamethasone coadministered orally as 8 mg on Days 2 through 5, increased the AUC of dexamethasone, a CYP3A4 substrate by 2.2-fold, on Days 1 and 5.", "output": "<Aprepitant, mechanism, dexamethasone>, <Aprepitant, mechanism, dexamethasone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The oral dexamethasone doses should be reduced by approximately 50% when coadministered with Aprepitant, to achieve exposures of dexamethasone similar to those obtained when it is given without Aprepitant.", "output": "<dexamethasone, advise, Aprepitant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The daily dose of dexamethasone administered in clinical studies with Aprepitant reflects an approximate 50% reduction of the dose of dexamethasone.", "output": "<dexamethasone, mechanism, Aprepitant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aprepitant, when given as a regimen of 125 mg on Day 1 and 80 mg/day on Days 2 and 3, increased the AUC of methylprednisolone, a CYP3A4 substrate, by 1.34-fold on Day 1 and by 2.5-fold on Day 3, when methylprednisolone was coadministered intravenously as 125 mg on Day 1 and orally as 40 mg on Days 2 and 3.", "output": "<Aprepitant, mechanism, methylprednisolone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The IV methylprednisolone dose should be reduced by approximately 25%, and the oral methylprednisolone dose should be reduced by approximately 50% when coadministered with Aprepitant to achieve exposures of methylprednisolone similar to those obtained when it is given without Aprepitant.", "output": "<methylprednisolone, advise, Aprepitant>, <methylprednisolone, advise, Aprepitant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although there was no effect of Aprepitant on the plasma AUC of R(+) or S(-) warfarin determined on Day 3, there was a 34% decrease in S(-)warfarin (a CYP2C9 substrate) trough concentration accompanied by a 14% decrease in the prothrombin time (reported as International Normalized Ratio or INR) 5 days after completion of dosing with Aprepitant.", "output": "<S(-)warfarin, mechanism, Aprepitant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients on chronic warfarin therapy, the prothrombin time (INR) should be closely monitored in the 2-week period, particularly at 7 to 10 days, following initiation of the 3-day regimen of Aprepitant with each chemotherapy cycle.", "output": "<warfarin, advise, Aprepitant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Tolbutamide: Aprepitant, when given as 125 mg on Day 1 and 80 mg/day on Days 2 and 3, decreased the AUC of tolbutamide (a CYP2C9 substrate) by 23% on Day 4, 28% on Day 8, and 15% on Day 15, when a single dose of tolbutamide 500 mg was admini,stered orally prior to the administration of the 3-day regimen of Aprepitant and on Days 4,8, and 15.", "output": "<tolbutamide, mechanism, Aprepitant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oral contraceptives: Aprepitant, when given once daily for 14 days as a 100-mg capsule with an oral contraceptive containing 35 mcg of ethinyl estradiol and 1 mg of norethindrone, decreased the AUC of ethinyl estradiol by 43%, and decreased the AUC of norethindrone by 8%;", "output": "<Aprepitant, mechanism, ethinyl estradiol>, <Aprepitant, mechanism, norethindrone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "therefore, the efficacy of oral contraceptives during administration of Aprepitant may be reduced.", "output": "<contraceptives, effect, Aprepitant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although a 3-day regimen of Aprepitant given concomitantly with oral contraceptives has not been studied, alternative or back-up methods of contraception should be used.", "output": "<Aprepitant, advise, contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Midazolam: Aprepitant increased the AUC of midazolam, a sensitive CYP3A4 substrate, by 2.3-fold on Day 1 and 3.3-fold on Day 5, when a single oral dose of midazolam 2 mg was coadministered on Day 1 and Day 5 of a regimen of Aprepitant 125 mg on Day 1 and 80 mg/day on Days 2 through 5.", "output": "<Aprepitant, mechanism, midazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The potential effects of increased plasma concentrations of midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) should be considered when coadministering these agents with Aprepitant.", "output": "<midazolam, advise, Aprepitant>, <benzodiazepines, advise, Aprepitant>, <alprazolam, advise, Aprepitant>, <triazolam, advise, Aprepitant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Aprepitant increased the AUC of midazolam by 25% on Day 4 and decreased the AUC of midazolam by 19% on Day 8 relative to the dosing of Aprepitant on Days 1 through 3.", "output": "<Aprepitant, mechanism, midazolam>, <Aprepitant, mechanism, midazolam>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Consequently, concomitant administration of Aprepitant with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir) should be approached with caution.", "output": "<Aprepitant, advise, ketoconazole>, <Aprepitant, advise, itraconazole>, <Aprepitant, advise, nefazodone>, <Aprepitant, advise, troleandomycin>, <Aprepitant, advise, clarithromycin>, <Aprepitant, advise, ritonavir>, <Aprepitant, advise, nelfinavir>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because moderate CYP3A4 inhibitors (e.g., diltiazem) result in 2-fold increase in plasma concentrations of aprepitant, concomitant administration should also be approached with caution.", "output": "<diltiazem, advise, aprepitant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "therefore, coadministration of Aprepitant with drugs that strongly induce CYP3A4 activity (e.g., rifampin, carbamazepine, phenytoin) may result in reduced plasma concentrations of aprepitant that may result in decreased efficacy of Aprepitant.", "output": "<Aprepitant, mechanism, rifampin>, <Aprepitant, mechanism, phenytoin>, <Aprepitant, mechanism, aprepitant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ketoconazole: When a single 125-mg dose of Aprepitant was administered on Day5 of a 10-day regimen of 400 mg/day of ketoconazole, a strong CYP3A4 inhibitor, the AUC of aprepitant increased approximately 5-fold and the mean terminal half-life of aprepitant increased approximately 3-fold.", "output": "<Aprepitant, mechanism, ketoconazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Rifampin: When a single 375-mg dose of Aprepitant was administered on Day9 of a 14-day regimen of 600 mg/day of rifampin, a strong CYP3A4 inducer, the AUC of aprepitant decreased approximately 11-fold and the mean terminal half-life decreased approximately 3-fold.", "output": "<Aprepitant, mechanism, rifampin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diltiazem: In patients with mild to moderate hypertension, administration of aprepitant once daily, as a tablet formulation comparable to 230 mg of the capsule formulation, with diltiazem 120 mg 3 times daily for 5 days, resulted in a 2-fold increase of aprepitant AUC and a simultaneous 1.7-fold increase of diltiazem AUC.", "output": "<aprepitant, mechanism, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Paroxetine: Coadministration of once daily doses of aprepitant, as a tablet formulation comparable to 85 mg or 170 mg of the capsule formulation, with paroxetine 20 mg once daily, resulted in a decrease in AUC by approximately 25% and Cmax, by approximately 20% of both aprepitant and paroxetine.", "output": "<aprepitant, mechanism, paroxetine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.", "output": "<tetracyclines, advise, anticoagulant>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin.", "output": "<tetracyclines, advise, penicillin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.", "output": "<tetracyclines, mechanism, aluminum>, <tetracyclines, mechanism, calcium>, <tetracyclines, mechanism, magnesium>, <tetracyclines, mechanism, iron>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Absorption of tetracycline is impaired by bismuth subsalicylate.", "output": "<tetracycline, mechanism, bismuth subsalicylate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.", "output": "<Barbiturates, mechanism, doxycycline>, <carbamazepine, mechanism, doxycycline>, <phenytoin, mechanism, doxycycline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concurrent use of tetracycline and Penthrane (methoxyflurane) has been reported to result in fatal renal toxicity.", "output": "<tetracycline, effect, Penthrane>, <tetracycline, effect, methoxyflurane>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Concurrent use of tetracycline may render oral contraceptives less effective.", "output": "<tetracycline, effect, contraceptives>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In addition to bleeding associated with heparin and vitamin K antagonists, drugs that alter platelet function (such as acetylsalicylic acid, dipyridamole and Abciximab) may increase the risk of bleeding if administered prior to, during, or after Activase therapy.", "output": "<heparin, effect, Activase>, <vitamin K antagonists, effect, Activase>, <acetylsalicylic acid, int, Activase>, <dipyridamole, effect, Activase>, <Abciximab, effect, Activase>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients receiving other narcotic analgesics, antipsychotics, antianxiety agents, or other CNS depressants (including alcohol) concomitantly with hydrocodone and acetaminophen tablets may exhibit an additive CNS depression.", "output": "<narcotic analgesics, effect, hydrocodone>, <antipsychotics, effect, hydrocodone>, <antianxiety agents, effect, hydrocodone>, <CNS depressants, effect, hydrocodone>, <alcohol, effect, hydrocodone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The use of MAO inhibitors or tricyclic antidepressants with hydrocodone preparations may increase the effect of either the antidepressant or hydrocodone.", "output": "<MAO inhibitors, effect, hydrocodone>, <tricyclic antidepressants, effect, hydrocodone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concurrent use of anticholinergics with hydrocodone may produce paralytic ileus.", "output": "<anticholinergics, effect, hydrocodone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Due to a theoretical risk of a pharmacodynamic interaction, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and FROVA within 24 hours of each other should be avoided (see  a href= frova_od.htm#CI CONTRAINDICATIONS).", "output": "<ergotamine, advise, FROVA>, <ergot-type medications, advise, FROVA>, <dihydroergotamine, advise, FROVA>, <methysergide, advise, FROVA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Selective serotonin reuptake inhibitors (SSRIs) (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline) have been reported, rarely, to cause weakness, hyperreflexia, and incoordination when coadministered with 5-HT1 agonists.", "output": "<Selective serotonin reuptake inhibitors, effect, 5-HT1 agonists>, <SSRIs, effect, 5-HT1 agonists>, <fluoxetine, effect, 5-HT1 agonists>, <fluvoxamine, effect, 5-HT1 agonists>, <paroxetine, effect, 5-HT1 agonists>, <sertraline, effect, 5-HT1 agonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "If concomitant treatment with frovatriptan and an SSRI is clinically warranted, appropriate observation of the patient is advised.", "output": "<frovatriptan, advise, SSRI>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines.", "output": "<decongestants, advise, tricyclic antidepressants>, <anesthetics, advise, tricyclic antidepressants>, <sympathomimetic amine, advise, tricyclic antidepressants>, <epinephrine, advise, tricyclic antidepressants>, <norepinephrine, advise, tricyclic antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Imipramine hydrochloride may potentiate the effects of CNS depressant drugs.", "output": "<Imipramine hydrochloride, effect, CNS depressant drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary.", "output": "<imipramine, mechanism, cimetidine>, <imipramine, mechanism, fluoxetine>, <imipramine, mechanism, barbiturates>, <imipramine, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved.", "output": "<SSRI, int, TCA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oral neomycin inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil.", "output": "<neomycin, mechanism, penicillin V>, <neomycin, mechanism, vitamin B-12>, <neomycin, mechanism, methotrexate>, <neomycin, mechanism, 5-fluorouracil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Oral neomycin sulfate may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability.", "output": "<neomycin sulfate, effect, coumarin>, <neomycin sulfate, effect, anticoagulants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Antacids and kaolin: Antacids and kaolin can reduce absorption of chloroquine;", "output": "<Antacids, mechanism, chloroquine>, <kaolin, mechanism, chloroquine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cimetidine: Cimetidine can inhibit the metabolism of chloroquine, increasing its plasma level.", "output": "<Cimetidine, mechanism, chloroquine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Ampicillin: In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin.", "output": "<chloroquine, mechanism, ampicillin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporin: After introduction of chloroquine (oral form), a sudden increase in serum cyclosporin level has been reported.", "output": "<chloroquine, mechanism, cyclosporin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The coadministration of aspirin decreases the biologic half-life of fenoprofen because of an increase in metabolic clearance that results in a greater amount of hydroxylated fenoprofen in the urine.", "output": "<aspirin, mechanism, fenoprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Although the mechanism of interaction between fenoprofen and aspirin is not totally known, enzyme induction and displacement of fenoprofen from plasma albumin binding sites are possibilities.", "output": "<fenoprofen, mechanism, aspirin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because Nalfon has not been shown to produce any additional effect beyond that obtained with aspirin alone and because aspirin increases the rate of excretion of Nalfon, the concomitant use of Nalfon and salicylates is not recommended.", "output": "<aspirin, mechanism, Nalfon>, <Nalfon, advise, salicylates>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chronic administration of phenobarbital, a known enzyme inducer, may be associated with a decrease in the plasma half-life of fenoprofen.", "output": "<phenobarbital, mechanism, fenoprofen>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When phenobarbital is added to or withdrawn from treatment, dosage adjustment of Nalfon may be required.", "output": "<phenobarbital, advise, Nalfon>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients receiving coumarin-type anticoagulants, the addition of Nalfon to therapy could prolong the prothrombin time.", "output": "<coumarin-type anticoagulants, effect, Nalfon>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Patients treated with Nalfon may be resistant to the effects of loop diuretics.", "output": "<Nalfon, effect, loop diuretics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients receiving Nalfon and a steroid concomitantly, any reduction in steroid dosage should be gradual in order to avoid the possible complications of sudden steroid withdrawal.", "output": "<Nalfon, advise, steroid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "WelChol  decreased the Cmax and AUC of sustained-release verapamil (Calan SR ) by approximately 31% and 11%, respectively.", "output": "<WelChol, mechanism, verapamil>, <WelChol, mechanism, Calan SR>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "DIAMOX modifies phenytoin metabolism with increased serum levels of phenytoin.", "output": "<DIAMOX, mechanism, phenytoin>, <DIAMOX, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect.", "output": "<DIAMOX, mechanism, primidone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone.", "output": "<DIAMOX, advise, primidone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetazolamide may increase the effects of other folic acid antagonists.", "output": "<Acetazolamide, effect, folic acid antagonists>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect.", "output": "<Acetazolamide, mechanism, amphetamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetazolamide reduces urinary excretion of quinidine and may enhance its effect.", "output": "<Acetazolamide, mechanism, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetazolamide may prevent the urinary antiseptic effect of methenamine.", "output": "<Acetazolamide, effect, methenamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetazolamide increases lithium excretion and the lithium may be decreased.", "output": "<Acetazolamide, mechanism, lithium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetazolamide and sodium bicarbonate used concurrently increases the risk of renal calculus formation.", "output": "<Acetazolamide, effect, sodium bicarbonate>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Acetazolamide may elevate cyclosporine levels.", "output": "<Acetazolamide, mechanism, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since PLETAL is extensively metabolized by cytochrome P-450 isoenzymes, caution should be exercised when PLETAL is coadministered with inhibitors of C.P.A. such as ketoconazole and erythromycin or inhibitors of CYP2C19 such as omeprazole.", "output": "<PLETAL, advise, ketoconazole>, <PLETAL, advise, erythromycin>, <PLETAL, advise, omeprazole>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Pharmacokinetic studies have demonstrated that omeprazole and erythromycin significantly increased the systemic exposure of cilostazol and/or its major metabolites.", "output": "<omeprazole, mechanism, cilostazol>, <erythromycin, mechanism, cilostazol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Population pharmacokinetic studies showed higher concentrations of cilostazol among patients concurrently treated with diltiazem, an inhibitor of C.P.A..", "output": "<cilostazol, mechanism, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Animal experience indicates that clorazepate dipotassium prolongs the sleeping time after hexobarbital or after ethyl alcohol, increases the inhibitory effects of chlorpromazine, but does not exhibit monoamine oxidase inhibition.", "output": "<clorazepate dipotassium, effect, hexobarbital>, <clorazepate dipotassium, effect, ethyl alcohol>, <clorazepate dipotassium, effect, chlorpromazine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The actions of the benzodiazepines may be potentiated by barbiturates, narcotics, phenothiazines, monoamine oxidase inhibitors or other antidepressants.", "output": "<benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, narcotics>, <benzodiazepines, effect, phenothiazines>, <benzodiazepines, effect, monoamine oxidase inhibitors>, <benzodiazepines, effect, antidepressants>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phospholine Iodide potentiates other cholinesterase inhibitors such as succinylcholine or organophosphate and carbamate insecticides.", "output": "<Phospholine Iodide, effect, cholinesterase inhibitors>, <Phospholine Iodide, effect, succinylcholine>, <Phospholine Iodide, effect, organophosphate insecticide>, <Phospholine Iodide, effect, carbamate insecticide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibiotics or potent diuretics such as furosemide.", "output": "<cephalosporins, effect, aminoglycoside antibiotics>, <cephalosporins, effect, diuretics>, <cephalosporins, effect, furosemide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Chloramphenicol has been shown to be antagonistic to beta-lactam antibiotics, including ceftazidime, based on in vitro studies and time kill curves with enteric gram-negative bacilli.", "output": "<Chloramphenicol, effect, beta-lactam antibiotics>, <Chloramphenicol, effect, ceftazidime>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Anakinra: Concurrent administration of anakinra (an interleukin-1 antagonist) and another TNF-blocking agent has been associated with an increased risk of serious infections, an increased risk of neutropenia and no additional benefit compared to these medicinal products alone.", "output": "<anakinra, effect, TNF-blocking agent>, <interleukin-1 antagonist, effect, TNF-blocking agent>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore the, combination of anakinra with other TNF-blocking agents, including HUMIRA, may also result i n similar toxicities.", "output": "<anakinra, effect, TNF-blocking agents>, <anakinra, effect, HUMIRA>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concurrent use of two or more drugs with anticholinergic activity--such as an antipsychotic drug (eg, chlorpromazine), an antiparkinsonian drug (eg, trihexyphenidyl), and/or a tricyclic antidepressant (eg, amitriptyline)--commonly results in excessive anticholinergic effects, including dry mouth and associated dental complications, blurred vision, and, in patients exposed to high temperature and humidity, hyperpyrexia.", "output": "<antipsychotic drug, effect, antiparkinsonian drug>, <antipsychotic drug, effect, trihexyphenidyl>, <antipsychotic drug, effect, tricyclic antidepressant>, <antipsychotic drug, effect, amitriptyline>, <chlorpromazine, effect, antiparkinsonian drug>, <chlorpromazine, effect, trihexyphenidyl>, <chlorpromazine, effect, tricyclic antidepressant>, <chlorpromazine, effect, amitriptyline>, <antiparkinsonian drug, effect, tricyclic antidepressant>, <antiparkinsonian drug, effect, amitriptyline>, <trihexyphenidyl, effect, tricyclic antidepressant>, <trihexyphenidyl, effect, amitriptyline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Isoflurane, enflurane, and halothane decrease the ED50 of NUROMAX by 30% to 45%.", "output": "<Isoflurane, mechanism, NUROMAX>, <enflurane, mechanism, NUROMAX>, <halothane, mechanism, NUROMAX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Other drugs which may enhance the neuromuscular blocking action of nondepolarizing agents such as NUROMAX include certain antibiotics (e. g., aminoglycosides, tetracyclines, bacitracin, polymyxins, lincomycin, clindamycin, colistin, and sodium colistimethate), magnesium salts, lithium, local anesthetics, procainamide, and quinidine.", "output": "<NUROMAX, effect, antibiotics>, <NUROMAX, effect, aminoglycosides>, <NUROMAX, effect, tetracyclines>, <NUROMAX, effect, bacitracin>, <NUROMAX, effect, polymyxins>, <NUROMAX, effect, lincomycin>, <NUROMAX, effect, clindamycin>, <NUROMAX, effect, colistin>, <NUROMAX, effect, sodium colistimethate>, <NUROMAX, effect, magnesium>, <NUROMAX, effect, lithium>, <NUROMAX, effect, anesthetics>, <NUROMAX, effect, procainamide>, <NUROMAX, effect, quinidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "As with some other nondepolarizing neuromuscular blocking agents, the time of onset of neuromuscular block induced by NUROMAX is lengthened and the duration of block is shortened in patients receiving phenytoin or carbamazepine.", "output": "<nondepolarizing neuromuscular blocking agents, effect, phenytoin>, <nondepolarizing neuromuscular blocking agents, effect, carbamazepine>, <NUROMAX, effect, phenytoin>, <NUROMAX, effect, carbamazepine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Plasma levels of anticonvulsant agents may become subtherapeutic during cisplatin therapy.", "output": "<anticonvulsant agents, mechanism, cisplatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "poor metabolizers of debrisoquin: Interactions of carvedilol with strong inhibitors of CYP2D6 (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol .", "output": "<quinidine, effect, carvedilol>, <fluoxetine, effect, carvedilol>, <paroxetine, effect, carvedilol>, <propafenone, effect, carvedilol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Catecholamine-depleting Agents: Patients taking both agents with b-blocking properties and a drug that can deplete catecholamines (e.g., reserpine and monoamine oxidase inhibitors) should be observed closely for signs of hypotension and/or severe bradycardia.", "output": "<agents with b-blocking properties, effect, reserpine>, <agents with b-blocking properties, effect, monoamine oxidase inhibitors>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Clonidine: Concomitant administration of clonidine with agents with b-blocking properties may potentiate blood-pressure- and heart-rate-lowering effects.", "output": "<clonidine, effect, agents with b-blocking properties>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "When concomitant treatment with agents with b-blocking properties and clonidine is to be terminated, the b-blocking agent should be discontinued first.", "output": "<agents with b-blocking properties, advise, clonidine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Cyclosporine: Modest increases in mean trough cyclosporine concentrations were observed following initiation of carvedilol treatment in 21 renal transplant patients suffering from chronic vascular rejection.", "output": "<cyclosporine, mechanism, carvedilol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Due to wide interindividual variability in the dose adjustment required, it is recommended that cyclosporine concentrations be monitored closely after initiation of carvedilol therapy and that the dose of cyclosporine be adjusted as appropriate.", "output": "<cyclosporine, advise, carvedilol>, <carvedilol, advise, cyclosporine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Digoxin: Digoxin concentrations are increased by about 15% when digoxin and carvedilol are administered concomitantly.", "output": "<digoxin, mechanism, carvedilol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Both digoxin and COREG slow AV conduction.", "output": "<digoxin, effect, COREG>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Therefore, increased monitoring of digoxin is recommended when initiating, adjusting, or discontinuing COREG.", "output": "<digoxin, advise, COREG>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Inducers and Inhibitors of Hepatic Metabolism: Rifampin reduced plasma concentrations of carvedilol by about 70%.", "output": "<Rifampin, mechanism, carvedilol>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Calcium Channel Blockers: Isolated cases of conduction disturbance (rarely with hemodynamic compromise) have been observed when COREG is co-administered with diltiazem.", "output": "<COREG, effect, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "As with other agents with b-blocking properties, if COREG is to be administered orally with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored.", "output": "<COREG, advise, verapamil>, <COREG, advise, diltiazem>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Insulin or Oral Hypoglycemics: Agents with b-blocking properties may enhance the blood-sugar-reducing effect of insulin and oral hypoglycemics.", "output": "<Agents with b-blocking properties, effect, insulin>, <Agents with b-blocking properties, effect, hypoglycemics>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Elevated plasma levels of theophylline have been reported with concomitant quinolone use.", "output": "<theophylline, mechanism, quinolone>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "There have been reports of theophylline-related side effects in patients on concomitant therapy with norfloxacin and theophylline.", "output": "<norfloxacin, effect, theophylline>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with norfloxacin.", "output": "<cyclosporine, mechanism, norfloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Quinolones, including norfloxacin, may enhance the effects of oral anticoagulants, including warfarin or its derivatives or similar agents.", "output": "<Quinolones, effect, anticoagulants>, <Quinolones, effect, warfarin>, <norfloxacin, effect, anticoagulants>, <norfloxacin, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant administration of quinolones including norfloxacin with glyburide (a sulfonylurea agent) has, on rare occasions, resulted in severe hypoglycemia.", "output": "<quinolones, effect, glyburide>, <norfloxacin, effect, glyburide>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Diminished urinary excretion of norfloxacin has been reported during the concomitant administration of probenecid and norfloxacin.", "output": "<probenecid, mechanism, norfloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The concomitant use of nitrofurantoin is not recommended since nitrofurantoin may antagonize the antibacterial effect of Norfloxacin in the urinary tract.", "output": "<nitrofurantoin, effect, Norfloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Multivitamins, or other products containing iron or zinc, antacids or sucralfate should not be administered concomitantly with, or within 2 hours of, the administration of norfloxacin, because they may interfere with absorption resulting in lower serum and urine levels of norfloxacin.", "output": "<Multivitamins, advise, norfloxacin>, <iron, advise, norfloxacin>, <zinc, advise, norfloxacin>, <antacids, advise, norfloxacin>, <sucralfate, advise, norfloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Videx (Didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be administered concomitantly with, or within 2 hours of, the administration of norfloxacin, because these products may interfere with absorption resulting in lower serum and urine levels of norfloxacin.", "output": "<Videx, advise, norfloxacin>, <Didanosine, advise, norfloxacin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Some quinolones have also been shown to interfere with the metabolism of caffeine.", "output": "<quinolones, mechanism, caffeine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Interactions attributed to the combined use of baclofen injection and epidural morphine include hypotension and dyspnea.", "output": "<baclofen, effect, morphine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended that the combination of intravenous dantrolene sodium and calcium channel blockers, such as verapamil, not be used together during the management of malignant hyperthermia crisis until the relevance of these findings to humans is established.", "output": "<dantrolene sodium, advise, calcium channel blockers>, <dantrolene sodium, advise, verapamil>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Administration of dantrolene may potentiate vecuronium-induced neuromuscular block.", "output": "<dantrolene, effect, vecuronium>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "The vasodilating effects of nitroglycerin may be additive with those of other vasodilators.", "output": "<nitroglycerin, effect, vasodilators>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination.", "output": "<calcium channel blockers, effect, nitrates>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In patients receiving nonselective monoamine oxidase inhibitors (MAOIs) (e.g., selegiline hydrochloride) in combination with serotoninergic agents (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine), there have been reports of serious, sometimes fatal, reactions.", "output": "<monoamine oxidase inhibitors, effect, serotoninergic agents>, <monoamine oxidase inhibitors, effect, fluoxetine>, <monoamine oxidase inhibitors, effect, fluvoxamine>, <monoamine oxidase inhibitors, effect, paroxetine>, <monoamine oxidase inhibitors, effect, sertraline>, <monoamine oxidase inhibitors, effect, venlafaxine>, <MAOIs, effect, serotoninergic agents>, <MAOIs, effect, fluoxetine>, <MAOIs, effect, fluvoxamine>, <MAOIs, effect, paroxetine>, <MAOIs, effect, sertraline>, <MAOIs, effect, venlafaxine>, <selegiline hydrochloride, effect, serotoninergic agents>, <selegiline hydrochloride, effect, fluoxetine>, <selegiline hydrochloride, effect, fluvoxamine>, <selegiline hydrochloride, effect, paroxetine>, <selegiline hydrochloride, effect, sertraline>, <selegiline hydrochloride, effect, venlafaxine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because dexfenfluramine is a serotonin releaser and reuptake inhibitor, dexfenfluramine should not be used concomitantly with a MAO inhibitor.", "output": "<dexfenfluramine, advise, MAO inhibitor>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "At least 14 days should elapse between discontinuation of a MAO inhibitor and initiation of treatment with dexfenfluramine.", "output": "<MAO inhibitor, advise, dexfenfluramine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "At least 3 weeks should elapse between discontinuation of dexfenfluramine and initiation of treatment with a MAO inhibitor.", "output": "<dexfenfluramine, advise, MAO inhibitor>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "A rare, but serious, constellation of symptoms, termed serotonin syndrome, has been reported with the concomitant use of selective serotonin reuptake inhibitors (SSRIs) and agents for migraine therapy, such as Imitrex (sumatriptan succinate) and dihydroergotamine.", "output": "<selective serotonin reuptake inhibitors, effect, Imitrex>, <selective serotonin reuptake inhibitors, effect, sumatriptan succinate>, <selective serotonin reuptake inhibitors, effect, dihydroergotamine>, <SSRIs, effect, Imitrex>, <SSRIs, effect, sumatriptan succinate>, <SSRIs, effect, dihydroergotamine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Dexfenfluramine should not be administered with other serotoninergic agents.", "output": "<Dexfenfluramine, advise, serotoninergic agents>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Itraconazole decreases busulfan clearance by up to 25%, and may produce AUCs   1500  M min in some patients.", "output": "<Itraconazole, mechanism, busulfan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Phenytoin increases the clearance of busulfan by 15% or more, possibly due to the induction of glutathione-S-transferase.", "output": "<Phenytoin, mechanism, busulfan>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Since the pharmacokinetics of BUSULFEX were studied in patients treated with phenytoin, the clearance of BUSULFEX at the recommended dose may be lower and exposure (AUC) higher in patients not treated with phenytoin.", "output": "<BUSULFEX, mechanism, phenytoin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Because busulfan is eliminated from the body via conjugation with glutathione, use of acetaminophen prior to ( 72 hours) or concurrent with BUSULFEX may result in reduced busulfan clearance based upon the known property of acetaminophen to decrease glutathione levels in the blood and tissues.", "output": "<acetaminophen, mechanism, BUSULFEX>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Trecator has been found to temporarily raise serum concentrations of isoniazid.", "output": "<Trecator, mechanism, isoniazid>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Trecator may potentiate the adverse effects of other antituberculous drugs administered concomitantly.", "output": "<Trecator, effect, antituberculous drugs>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "In particular, convulsions have been reported when ethionamide is administered with cycloserine and special care should be taken when the treatment regimen includes both of these drugs.", "output": "<ethionamide, effect, cycloserine>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Danazol: The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol particularly with higher doses of lovastatin (see WARNINGS, Myopathy/Rhabdomyolysis).", "output": "<danazol, effect, lovastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Amiodarone or Verapamil: The risk of myopathy/rhabdomyolysis is increased when either amiodarone or verapamil is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS, Myopathy/Rhabdomyolysis).", "output": "<amiodarone, effect, HMG-CoA reductase inhibitor class>, <verapamil, effect, HMG-CoA reductase inhibitor class>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "However, another HMG-CoA reductase inhibitor has been found to produce a less than two-second increase in prothrombin time in healthy volunteers receiving low doses of warfarin.", "output": "<HMG-CoA reductase inhibitor, effect, warfarin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "Also, bleeding and/or increased prothrombin time have been reported in a few patients taking coumarin anticoagulants concomitantly with lovastatin.", "output": "<coumarin anticoagulant, effect, lovastatin>"}
{"instruction": "Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.", "input": "It is recommended that in patients taking anticoagulants, prothrombin time be determined before starting lovastatin and frequently enough during early therapy to insure that no significant alteration of prothrombin time occurs.", "output": "<anticoagulants, advise, lovastatin>"}