Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Milk, milk products, and calcium-rich foods or drugs may impair the absorption of EMCYT.

Output: <calcium, mechanism, EMCYT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone.

Output: <allopurinol, effect, ampicillin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients.

Output: <ampicillin, effect, allopurinol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In common with other broad-spectrum antibiotics, AUGMENTIN XR may reduce the efficacy of oral contraceptives

Output: <broad-spectrum antibiotics, effect, contraceptives>, <AUGMENTIN XR, effect, contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Particular caution is necessary when using ROMAZICON in cases of mixed drug overdosage since the toxic effects (such as convulsions and cardiac dysrhythmias) of other drugs taken in overdose (especially cyclic antidepressants) may emerge with the reversal of the benzodiazepine effect by flumazenil.

Output: <ROMAZICON, effect, cyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although ROMAZICON exerts a slight intrinsic anticonvulsant effect, its abrupt suppression of the protective effect of a benzodiazepine agonist can give rise to convulsions in epileptic patients.

Output: <ROMAZICON, effect, benzodiazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ROMAZICON blocks the central effects of benzodiazepines by competitive interaction at the receptor level.

Output: <ROMAZICON, effect, benzodiazepines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolopyridazines and others, are also blocked by ROMAZICON.

Output: <zopiclone, effect, ROMAZICON>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution is advised when TRISENOX is coadministered with other medications that can prolong the QT interval (e.g. certain antiarrhythmics or thioridazine) or lead to electrolyte abnormalities (such as diuretics or amphotericin B).

Output: <TRISENOX, advise, antiarrhythmics>, <TRISENOX, advise, thioridazine>, <TRISENOX, advise, diuretics>, <TRISENOX, advise, amphotericin B>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy.

Output: <steroids, effect, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Barbiturates, phenytoin, or rifampin increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes.

Output: <Barbiturates, mechanism, fludrocortisone acetate>, <phenytoin, mechanism, fludrocortisone acetate>, <rifampin, mechanism, fludrocortisone acetate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oxytocin or other oxytocics (concurrent use with dinoprost may result in uterine hypertonus, possibly causing uterine rupture or cervical laceration, especially in the absence of adequate cervical dilatation;

Output: <Oxytocin, effect, dinoprost>, <oxytocics, effect, dinoprost>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetaminophen: A report of severe acetaminophen toxicity was reported in a patient receiving Isoniazid.

Output: <acetaminophen, effect, Isoniazid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is believed that the toxicity may have resulted from a previously unrecognized interaction between isoniazid and acetaminophen and a molecular basis for this interaction has been proposed.

Output: <isoniazid, effect, acetaminophen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furthermore it has been proposed that isoniazid resulted In induction of P-450IIE1 in the patients liver which, in turn, resulted in a greater proportion of the ingested acetaminophen being converted to the toxic metabolites.

Output: <isoniazid, mechanism, acetaminophen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Carbamazepine: Isoniazid is known to slow the metabolism of carbamazepine and increase its serum levels Carbamazepine levels should be determined prior to concurrent administration with isoniazid, signs and symptoms of carbamazepine toxicity should be monitored closely, and appropriate dosage adjustment of the anticonvulsant should be made.

Output: <Isoniazid, mechanism, carbamazepine>, <Carbamazepine, advise, isoniazid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: Potential interaction of Ketoconazole and Isoniazid may exist.

Output: <Ketoconazole, int, Isoniazid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin: Isoniazid may increase serum levels of phenytoin.

Output: <Isoniazid, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therophylline: A recent study has shown that concomitan administration of isoniazid and theophylline may cause elevated plasma levels of theophylline, and in some instances a slight decrease in the elimination of isoniazid.

Output: <isoniazid, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Valproate: A recent case study has shown a possible increase in the plasma level of valproate when co administered with isoniazid.

Output: <valproate, mechanism, isoniazid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Plasma valproate concentration should be monitored when isoniazid and valproate are co administered, and appropriate dosage adjustments of valproate should be made.

Output: <isoniazid, advise, valproate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of MYOBLOC and aminoglycosides or other agents interfering with neuromuscular transmission (e.g., curare-like compounds) should only be performed with caution as the effect of the toxin may be potentiated.

Output: <MYOBLOC, advise, aminoglycosides>, <MYOBLOC, advise, curare-like compounds>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hormonal Contraceptives, Including Oral, Injectable, Transdermal, and Implantable Contraceptives: An interaction study demonstrated that co-administration of bosentan and the oral hormonal contraceptive Ortho-Novum produced average decreases of norethindrone and ethinyl estradiol levels of 14% and 31%, respectively.

Output: <bosentan, mechanism, Ortho-Novum>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, hormonal contraceptives, including oral, injectable, transdermal, and implantable forms, may not be reliable when TRACLEER is co-administered.

Output: <hormonal contraceptives, effect, TRACLEER>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Steady-state bosentan plasma concentrations were 3- to 4-fold higher than in the absence of cyclosporine A.

Output: <bosentan, mechanism, cyclosporine A>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant administration of bosentan and cyclosporine A is contraindicated.

Output: <bosentan, advise, cyclosporine A>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of bosentan decreased the plasma concentrations of cyclosporine A (a CYP3A4 substrate) by approximately 50%.

Output: <bosentan, mechanism, cyclosporine A>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of tacrolimus and bosentan resulted in markedly increased plasma concentrations of bosentan in animals.

Output: <tacrolimus, mechanism, bosentan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be exercised if tacrolimus and bosentan are used together.

Output: <tacrolimus, advise, bosentan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, the concomitant administration of TRACLEER and glyburide is contraindicated, and alternative hypoglycemic agents should be considered.

Output: <TRACLEER, advise, glyburide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of bosentan decreased the plasma concentrations of glyburide by approximately 40%.

Output: <bosentan, mechanism, glyburide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Bosentan is also expected to reduce plasma concentrations of other oral hypoglycemic agents that are predominantly metabolized by CYP2C9 or CYP3A4.

Output: <Bosentan, mechanism, hypoglycemic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: Co-administration of bosentan 125 mg b.i.d. and ketoconazole, a potent CYP3A4 inhibitor, increased the plasma concentrations of bosentan by approximately 2-fold.

Output: <bosentan, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Simvastatin and Other Statins: Co-administration of bosentan decreased the plasma concentrations of simvastatin (a CYP3A4 substrate), and its active  -hydroxy acid metabolite, by approximately 50%.

Output: <bosentan, mechanism, simvastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Bosentan is also expected to reduce plasma concentrations of other statins that have significant metabolism by CYP3A4, such as lovastatin and atorvastatin.

Output: <Bosentan, mechanism, statins>, <Bosentan, mechanism, lovastatin>, <Bosentan, mechanism, atorvastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients using CYP3A4 metabolized statins should have cholesterol levels monitored after TRACLEER is initiated to see whether the statin dose needs adjustment.

Output: <statins, advise, TRACLEER>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin: Co-administration of bosentan 500 mg b.i.d. for 6 days decreased the plasma concentrations of both S-warfarin (a CYP2C9 substrate) and R-warfarin (a CYP3A4 substrate) by 29 and 38%, respectively.

Output: <bosentan, mechanism, S-warfarin>, <bosentan, mechanism, R-warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, the potential exists for a drug interaction between WELLBUTRIN and drugs that affect the CYP2B6 isoenzyme (e.g., orphenadrine and cyclophosphamide).

Output: <WELLBUTRIN, int, orphenadrine>, <WELLBUTRIN, int, cyclophosphamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: While not systematically studied, certain drugs may induce the metabolism of bupropion (e.g., carbamazepine, phenobarbital, phenytoin).

Output: <bupropion, mechanism, carbamazepine>, <bupropion, mechanism, phenobarbital>, <bupropion, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a study of 15 male subjects (ages 19 to 35 years) who were extensive metabolizers of the CYP2D6 isoenzyme, daily doses of bupropion given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the Cmax, AUC, and t1/2 of desipramine by an average of approximately 2-, 5- and 2-fold, respectively.

Output: <bupropion, mechanism, desipramine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, co-administration of bupropion with drugs that are metabolized by CYP2D6 isoenzyme including certain antidepressants (e.g., nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide), should be approached with caution and should be initiated at the lower end of the dose range of the concomitant medication.

Output: <bupropion, advise, antidepressants>, <bupropion, advise, nortriptyline>, <bupropion, advise, imipramine>, <bupropion, advise, desipramine>, <bupropion, advise, paroxetine>, <bupropion, advise, fluoxetine>, <bupropion, advise, sertraline>, <bupropion, advise, antipsychotics>, <bupropion, advise, haloperidol>, <bupropion, advise, risperidone>, <bupropion, advise, thioridazine>, <bupropion, advise, beta-blockers>, <bupropion, advise, metoprolol>, <bupropion, advise, Type 1C antiarrhythmics>, <bupropion, advise, propafenone>, <bupropion, advise, flecainide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: MAO Inhibitors: Studies in animals demonstrate that the acute toxicity of bupropion is enhanced by the MAO inhibitor phenelzine .

Output: <bupropion, effect, phenelzine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Levodopa and Amantadine: Limited clinical data suggest a higher incidence of adverse experiences in patients receiving bupropion concurrently with either levodopa or amantadine.

Output: <bupropion, effect, levodopa>, <bupropion, effect, amantadine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of WELLBUTRIN Tablets to patients receiving either levodopa or amantadine concurrently should be undertaken with caution, using small initial doses and small gradual dose increases.

Output: <WELLBUTRIN, advise, levodopa>, <WELLBUTRIN, advise, amantadine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that Lower Seizure Threshold: Concurrent administration of WELLBUTRIN and agents (e.g., antipsychotics, other antidepressants, theophylline, systemic steroids, etc.) that lower seizure threshold should be undertaken only with extreme caution.

Output: <WELLBUTRIN, advise, antipsychotics>, <WELLBUTRIN, advise, antidepressants>, <WELLBUTRIN, advise, theophylline>, <WELLBUTRIN, advise, steroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Alcohol: In post-marketing experience, there have been rare reports of adverse neuropsychiatric events or reduced alcohol tolerance in patients who were drinking alcohol during treatment with WELLBUTRIN.

Output: <alcohol, effect, WELLBUTRIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The consumption of alcohol during treatment with WELLBUTRIN should be minimized or avoided (also see  a href= bupropz_od.htm#CI CONTRAINDICATIONS)

Output: <alcohol, advise, WELLBUTRIN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent administration of a TNF antagonist with ORENCIA has been associated with an increased risk of serious infections and no significant additional efficacy over use of the TNF antagonists alone.

Output: <TNF antagonist, effect, ORENCIA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent therapy with ORENCIA and TNF antagonists is not recommended.

Output: <ORENCIA, advise, TNF antagonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There is insufficient experience to assess the safety and efficacy of ORENCIA administered concurrently with anakinra, and therefore such use is not recommended.

Output: <ORENCIA, advise, anakinra>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cholestyramine and Charcoal Administration of cholestyramine or activated charcoal in patients (n=13) and volunteers (n=96) resulted in a rapid and significant decrease in plasma M1 (the active metabolite of leflunomide) concentration .

Output: <cholestyramine, mechanism, leflunomide>, <activated charcoal, mechanism, leflunomide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a small (n=30) combination study of ARAVA with methotrexate, a 2- to 3-fold elevation in liver enzymes was seen in 5 of 30 patients.

Output: <ARAVA, effect, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rifampin: Following concomitant administration of a single dose of ARAVA to subjects receiving multiple doses of rifampin, M1 peak levels were increased (~40%) over those seen when ARAVA was given alone.

Output: <ARAVA, mechanism, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because of the potential for ARAVA levels to continue to increase with multiple dosing, caution should be used if patients are to be receiving both ARAVA and rifampin.

Output: <ARAVA, advise, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin: Increased INR (International Normalized Ratio) when ARAVA and warfarin were co-administered has been rarely reported.

Output: <ARAVA, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Animal studies indicate that dobutamine may be ineffective if the patient has recently received a b-blocking drug.

Output: <dobutamine, effect, b-blocking drug>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Preliminary studies indicate that the concomitant use of dobutamine and nitroprusside results in a higher cardiac output and, usually, a lower pulmonary wedge pressure than when either drug is used alone.

Output: <dobutamine, effect, nitroprusside>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, when heparin sodium is given with dicumarol or warfarin sodium, a period of at least 5 hours after the last intravenous dose or 24 hours after the last subcutaneous dose should elapse before blood is drawn if a valid prothrombin time is to be obtained.

Output: <heparin sodium, advise, dicumarol>, <heparin sodium, advise, warfarin sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Platelet inhibitors: Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.

Output: <acetylsalicylic acid, effect, heparin sodium>, <dextran, effect, heparin sodium>, <phenylbutazone, effect, heparin sodium>, <ibuprofen, effect, heparin sodium>, <indomethacin, effect, heparin sodium>, <dipyridamole, effect, heparin sodium>, <hydroxychloroquine, effect, heparin sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The anticoagulant effect of heparin is enhanced by concurrent treatment with antithrombin III (human) in patients with hereditary antithrombin III deficiency.

Output: <heparin, effect, antithrombin III>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus in order to avoid bleeding, reduced dosage of heparin is recommended during treatment with antithrombin III (human).

Output: <heparin, advise, antithrombin III>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs Decreasing Heparin Effect: Digitalis, tetracyclines, nicotine, or antihistamines may partially counteract the anticoagulant action of heparin sodium.

Output: <Digitalis, effect, heparin sodium>, <tetracyclines, effect, heparin sodium>, <nicotine, effect, heparin sodium>, <antihistamines, effect, heparin sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Steady-state serum concentrations of tricyclic antidepressants are reported to fluctuate significantly when cimetidine is either added or deleted from the drug regimen.

Output: <tricyclic antidepressants, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Serious anticholinergic symptoms (severe dry mouth, urinary retention, blurred vision) have been associated with elevations in the serum levels of tricyclic antidepressants when cimetidine is added to the drug regimen.

Output: <tricyclic antidepressants, effect, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition, higher-than expected steady-state serum concentrations of tricyclic antidepressants have been observed when therapy is initiated in patients already taking cimetidine.

Output: <tricyclic antidepressants, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In well-controlled patients undergoing concurrent therapy with cimetidine, a decrease in the steady-state serum concentrations of tricyclic antidepressants may occur when cime-tidine therapy is discontinued.

Output: <cimetidine, mechanism, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The therapeutic efficacy of tricyclic antidepressants may be compromised in these patients when cimetidine is discontinued.

Output: <tricyclic antidepressants, effect, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been greater than 2-fold increases in previously stable plasma levels of other antidepressants, including nortriptyline, when fluoxetine hydrochloride has been administered in combination with these agents.

Output: <antidepressants, mechanism, fluoxetine hydrochloride>, <nortriptyline, mechanism, fluoxetine hydrochloride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of reserpine during therapy with a tricyclic antidepressant has been shown to produce a  stimulating  effect in some depressed patients.

Output: <reserpine, effect, tricyclic antidepressant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Close supervision and careful adjustment of the dosage are required when nortriptyline hydrochloride is used with other anticholinergic drugs or sympathomimetic drugs.

Output: <nortriptyline hydrochloride, advise, anticholinergic drugs>, <nortriptyline hydrochloride, advise, sympathomimetic drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, co-administration of tricyclic antidepressants with other drugs that are metabolized by this isoenzyme, including other antidepressants, phenothiazines, carbamazepine, and Type 1C antiarrhythmics (eg, propafenone, flecainide, and encainide), or that inhibit this enzyme (eg, quinidine), should be approached with caution.

Output: <tricyclic antidepressants, advise, antidepressants>, <tricyclic antidepressants, advise, phenothiazines>, <tricyclic antidepressants, advise, carbamazepine>, <tricyclic antidepressants, advise, Type 1C antiarrhythmics>, <tricyclic antidepressants, advise, propafenone>, <tricyclic antidepressants, advise, flecainide>, <tricyclic antidepressants, advise, encainide>, <tricyclic antidepressants, advise, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although specific drug interaction studies have not been conducted with ALPHAGAN P, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered.

Output: <ALPHAGAN P, advise, CNS depressants>, <ALPHAGAN P, advise, alcohol>, <ALPHAGAN P, advise, barbiturates>, <ALPHAGAN P, advise, opiates>, <ALPHAGAN P, advise, sedatives>, <ALPHAGAN P, advise, anesthetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.It is not known whether the concurrent use of these agents with ALPHAGAN P in humans can lead to resulting interference with the IOP lowering effect.

Output: <Tricyclic antidepressants, effect, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oral Anticoagulants CAUTION SHOULD BE EXERCISED WHEN COUMARIN ANTICOAGULANTS ARE GIVEN IN CONJUNCTION WITH TRICOR.

Output: <COUMARIN ANTICOAGULANTS, advise, TRICOR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: HMG-CoA reductase inhibitors: The combined use of TRICOR and HMG-CoA reductase inhibitors should be avoided unless the benefit of further alterations in lipid levels is likely to outweigh the increased risk of this drug combination.

Output: <TRICOR, advise, HMG-CoA reductase inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Resins: Since bile acid sequestrants may bind other drugs given concurrently, patients should take TRICOR at least 1 hour before or 4-6 hours after a bile acid binding resin to avoid impeding its absorption.

Output: <TRICOR, mechanism, bile acid binding resin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporine: Because cyclosporine can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including TRICOR, there is a risk that an interaction will lead to deterioration.

Output: <cyclosporine, effect, fibrate drugs>, <cyclosporine, effect, TRICOR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The benefits and risks of using TRICOR with immunosuppressants and other potentially nephrotoxic agents should be carefully considered, and the lowest effective dose employed

Output: <TRICOR, advise, immunosuppressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, fenofibrate should be taken at least 1 hour before or 4-6 hours after a bile acid binding resin to avoid impeding its absorption .

Output: <fenofibrate, advise, bile acid binding resin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of fenofibrate (equivalent to 145mg TRICOR) with pravastatin (40 mg) once daily for 10 days has been shown to increase the mean Cmax and AUC values for pravastatin by 36% (range from 69% decrease to 321% increase) and 28% (range from 54% decrease to 128% increase), respectively, and for 3 -hydroxy-iso-pravastatin by 55% (range from 32% decrease to 314% increase) and 39% (range from 24% decrease to 261% increase), respectively in 23 healthy adults.

Output: <fenofibrate, mechanism, pravastatin>, <TRICOR, mechanism, pravastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of fenofibrate (equivalent to 145 mg TRICOR) with atorvastatin (20 mg) once daily for 10 days resulted in approximately 17% decrease (range from 67% decrease to 44% increase) in atorvastatin AUC values in 22 healthy males.

Output: <fenofibrate, mechanism, atorvastatin>, <TRICOR, mechanism, atorvastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The daily dose of ENABLEX should not exceed 7.5 mg when coadministered with potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, nelfinavir, clarithromycin and nefazadone) .

Output: <ENABLEX, advise, ketoconazole>, <ENABLEX, advise, itraconazole>, <ENABLEX, advise, ritonavir>, <ENABLEX, advise, nelfinavir>, <ENABLEX, advise, clarithromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be taken when ENABLEX is used concomitantly with medications that are predominantly metabolized by CYP2D6 and which have a narrow therapeutic window, such as flecainide, thioridazine and tricyclic antidepressants (see CLINICAL PHARMACOLOGY).

Output: <ENABLEX, advise, flecainide>, <ENABLEX, advise, thioridazine>, <ENABLEX, advise, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant use of ENABLEX with other anticholinergic agents may increase the frequency and/or severity of dry mouth, constipation, blurred vision and other anticholinergic pharmacological effects.

Output: <ENABLEX, effect, anticholinergic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent administration of HEXALEN and antidepressants of the MAO inhibitor class may cause severe orthostatic hypotension.Cimetidine, an inhibitor of microsomal drug metabolism, increased altretamines half-life and toxicity in a rat model.

Output: <HEXALEN, effect, antidepressants of the MAO inhibitor class>, <Cimetidine, mechanism, altretamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Data from a randomized trial of HEXALEN and cisplatin plus or minus pyridoxine in ovarian cancer indicated that pyridoxine significantly reduced neurotoxicity;

Output: <HEXALEN, effect, cisplatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: however, it adversely affected response duration suggesting that pyridoxine should not be administered with HEXALEN and/or cisplatin.1

Output: <pyridoxine, advise, HEXALEN>, <pyridoxine, advise, cisplatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Special consideration should be given to the administration of ETHYOL in patients receiving antihypertensive medications or other drugs that could cause or potentiate hypotension.

Output: <ETHYOL, advise, antihypertensive medications>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Valproate: Tiagabine causes a slight decrease (about 10%) in steady-state valproate concentrations.

Output: <Tiagabine, mechanism, valproate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Effects of other Antiepilepsy Drugs (AEDs) on GABITRIL : Carbamazepine: Population pharmacokinetic analyses indicate that tiagabine clearance is 60% greater in patients taking carbamazepine with or without other enzyme- inducing AEDs.

Output: <tiagabine, mechanism, carbamazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin: Population pharmacokinetic analyses indicate that tiagabine clearance is 60% greater in patients taking phenytoin with or without other enzyme- inducing AEDs.

Output: <tiagabine, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenobarbital (Primidone): Population pharmacokinetic analyses indicate that tiagabine clearance is 60% greater in patients taking phenobarbital (primidone) with or without other enzyme-inducing AEDs.

Output: <tiagabine, mechanism, phenobarbital>, <tiagabine, mechanism, primidone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Valproate: The addition of tiagabine to patients taking valproate chronically had no effect on tiagabine pharmacokinetics, but valproate significantly decreased tiagabine binding in vitro from 96.3 to 94.8%, which resulted in an increase of approximately 40% in the free tiagabine concentration.

Output: <valproate, mechanism, tiagabine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because of the possible additive effects of drugs that may depress the nervous system, ethanol or triazolam should be used cautiously in combination with tiagabine.

Output: <ethanol, advise, tiagabine>, <triazolam, advise, tiagabine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sulfapyridine may interact with any of the following: - Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or

Output: <Sulfapyridine, int, Acetaminophen>, <Sulfapyridine, int, Tylenol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Antidiabetics, oral (diabetes medicine you take by mouth) Use of oral antidiabetics with sulfapyridine may increase the chance of side effects affecting the blood and/or the side effects or oral antidiabetics

Output: <antidiabetics, effect, sulfapyridine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Methotrexate (e.g., Mexate) Use of methotrexate with sulfapyridine may increase the chance of side effects affecting the liver and/or the side effects of methotrexate

Output: <methotrexate, effect, sulfapyridine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Methyldopa (e.g., Aldomet) Use of methyldopa with sulfapyridine may increase the chance of side effects affecting the liver and/or the blood

Output: <methyldopa, effect, sulfapyridine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Phenytoin (e.g., Dilantin) Use of phenytoin with sulfapyridine may increase the chance of side effects affecting the liver and/or the side effects of phenytoin

Output: <phenytoin, effect, sulfapyridine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Elevated plasma levels of theophylline have been reported with concomitant use of some quinolones.

Output: <theophylline, mechanism, quinolones>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been reports of theophylline-related side-effects in patients on concomitant theophylline-quinolone therapy.

Output: <theophylline, effect, quinolone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Quinolones have also been shown to interfere with the metabolism of caffeine.

Output: <Quinolones, mechanism, caffeine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although this interaction has not been reported with cinoxacin, caution should be exercised when cinoxacin is given concomitantly with caffeine-containing products.

Output: <cinoxacin, advise, caffeine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids or sucralfate substantially interfere with the absorption of some quinolones, resulting in low urine levels.

Output: <Antacids, mechanism, quinolones>, <sucralfate, mechanism, quinolones>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Also, concomitant administration of quinolones with products containing iron, multivitamins containing zinc, or Videx (didanosine) chewable/buffered tablets or the pediatric powder for oral solution may result in low urine levels.

Output: <quinolones, mechanism, iron>, <quinolones, mechanism, zinc>, <quinolones, mechanism, Videx>, <quinolones, mechanism, didanosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Quinolones, including cinoxacin, may enhance the effects of oral anticoagulants, such as warfarin or its derivatives.

Output: <Quinolones, effect, anticoagulants>, <Quinolones, effect, warfarin>, <cinoxacin, effect, anticoagulants>, <cinoxacin, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Seizures have been reported in patients taking another quinolone class antimicrobial and the nonsteroidal anti-inflammatory drug fenbufen concurrently.

Output: <quinolone class antimicrobial, effect, nonsteroidal anti-inflammatory drug>, <quinolone class antimicrobial, effect, fenbufen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Physicians are provided this information to increase awareness of the potential for serious interactions when cinoxacin and certain nonsteroidal anti-inflammatory agents are administered concomitantly.

Output: <cinoxacin, advise, nonsteroidal anti-inflammatory agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Elevated cyclosporine serum levels have been reported with the concomitant use of quinolones and cyclosporine.

Output: <quinolones, mechanism, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of quinolones with antacids containing aluminum, magnesium, or calcium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron or zinc, or with formulations containing divalent and trivalent cations such as VIDEX (didanosine) chewable/buffered tablets or the pediatric powder for oral solution, may substantially interfere with the absorption of quinolones, resulting in systemic concentrations considerably lower than desired.

Output: <quinolones, mechanism, aluminum>, <quinolones, mechanism, magnesium>, <quinolones, mechanism, calcium>, <quinolones, mechanism, sucralfate>, <quinolones, mechanism, iron>, <quinolones, mechanism, multivitamins>, <quinolones, mechanism, iron>, <quinolones, mechanism, zinc>, <quinolones, mechanism, VIDEX>, <quinolones, mechanism, didanosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caffeine Theobromine Grepafloxacin, like other quinolones, may inhibit the metabolism of caffeine and theobromine.

Output: <Grepafloxacin, mechanism, caffeine>, <Grepafloxacin, mechanism, theobromine>, <quinolones, mechanism, caffeine>, <quinolones, mechanism, theobromine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Theophylline: Grepafloxacin is a competitive inhibitor of the metabolism of theophylline.

Output: <Grepafloxacin, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Serum theophylline concentrations increase when grepafloxacin is initiated in a patient maintained on theophylline.

Output: <grepafloxacin, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When initiating a multi-day course of grepafloxacin in a patient maintained on theophylline, the theophylline maintenance dose should be halved for the period of concurrent use of grepafloxacin and monitoring of serum theophylline concentrations should be initiated as a guide to further dosage adjustments.

Output: <theophylline, advise, grepafloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, because some quinolones have been reported to enhance the effects of warfarin or its derivatives, prothrombin time or other suitable anticoagulation test should be monitored closely if a quinolone antimicrobial is administered with warfarin or its derivatives.

Output: <quinolones, effect, warfarin>, <quinolone antimicrobial, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs Metabolized by Cytochrome P450 Enzymes The drug interaction study evaluating the effect of grepafloxacin on theophylline indicates that grepafloxacin inhibits theophylline metabolism, which is mediated by CYP1A2.

Output: <grepafloxacin, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition, other quinolones have been reported to decrease the CYP3A4-mediated metabolism of cyclosporine.

Output: <quinolones, mechanism, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nonsteroidal Anti-inflammatory Drugs (NSAIDs): The concomitant administration of a nonsteroidal anti inflammatory drug with a quinolone may increase the risks of CNS stimulation and convulsions.

Output: <nonsteroidal anti inflammatory drug, effect, quinolone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antidiabetic Agents: Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent.

Output: <quinolones, effect, antidiabetic agent>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concurrent use of Robinul Injection with other anticholinergics or medications with anticholinergic activity, such as phenothiazines, antiparkinson drugs, or tricyclic antidepressants, may intensify the antimuscarinic effects and may result in an increase in anticholinergic side effects.

Output: <Robinul, effect, anticholinergics>, <Robinul, effect, phenothiazines>, <Robinul, effect, antiparkinson drugs>, <Robinul, effect, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of Robinul Injection and potassium chloride in a wax matrix may increase the severity of potassium chloride-induced gastrointestinal lesions as a result of a slower gastrointestinal transit time.

Output: <Robinul, mechanism, potassium chloride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oral doses of Antizol (10-20 mg/kg), via alcohol dehydrogenase inhibition, significantly reduced the rate of elimination of ethanol (by approximately 40%) given to healthy volunteers in moderate doses.

Output: <Antizol, mechanism, ethanol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Similarly, ethanol decreased the rate of elimination of Antizol (by approximately 50%) by the same mechanism.

Output: <ethanol, mechanism, Antizol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Reciprocal interactions may occur with concomitant use of Antizol and drugs that increase or inhibit the cytochrome P450 system (e.g., phenytoin, carbamazepine, cimetidine, ketoconazole), though this has not been studied

Output: <Antizol, mechanism, phenytoin>, <Antizol, mechanism, carbamazepine>, <Antizol, mechanism, cimetidine>, <Antizol, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When administered concurrently, the following drugs may interact with beta-adrenergic receptor blocking agents: Anesthetics, general: exaggeration of the hypotension induced by general anesthetics.

Output: <beta-adrenergic receptor blocking agents, int, Anesthetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Elevated plasma levels of theophylline have been reported with concomitant quinolone use.

Output: <theophylline, mechanism, quinolone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been reports of theophylline-related side effects in patients on concomitant therapy with quinolones and theophylline.

Output: <quinolones, effect, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Quinolones have been shown to interfere with the metabolism of caffeine.

Output: <Quinolones, mechanism, caffeine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Quinolones, including nalidixic acid, may enhance the effects of the oral anticoagulant warfarin or its derivatives.

Output: <Quinolones, effect, warfarin>, <nalidixic acid, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nitrofurantoin interferes with the therapeutic action of nalidixic acid.

Output: <Nitrofurantoin, effect, nalidixic acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: and Videx , (Didanosine), chewable/buffered tablets or the pediatric powder for oral solution may substantially interfere with the absorption of quinolones, resulting in systemic levels considerably lower than desired.

Output: <Videx, mechanism, quinolones>, <Didanosine, mechanism, quinolones>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Elevated serum levels of cyclosporine have been reported with the concomitant use of some quinolones and cyclosporine.

Output: <quinolones, mechanism, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Metformin: In healthy subjects given single 500 mg doses of cephalexin and metformin, plasma metformin mean cmax and AUC increased by an average of 34% and 24%, respectively, and metformin mean renal clearance decreased by 14%.

Output: <cephalexin, mechanism, metformin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although not observed in this study, adverse effects could potentially arise from co-administration of cephalexin and metformin by inhibition of tubular secretion via organic cationic transporter systems.

Output: <cephalexin, mechanism, metformin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Accordingly, careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking cephalexin and metformin.

Output: <cephalexin, advise, metformin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid: As with other b-lactams, the renal excretion of cephalexin is inhibited by probenecid.

Output: <cephalexin, mechanism, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be exercised when administering ETOPOPHOS with drugs that are known to inhibit phosphatase activities (e.g., levamisole hydrochloride).

Output: <ETOPOPHOS, advise, levamisole hydrochloride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: High-dose cyclosporin A resulting in concentrations above 2000 ng/mL administered with oral etoposide has led to an 80% increase in etoposide exposure with a 38% decrease in total body clearance of etoposide compared to etoposide alone.

Output: <cyclosporin A, mechanism, etoposide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diuretics: Patients on diuretics, especially those with intravascular volume depletion, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with fosinopril sodium.

Output: <diuretics, effect, fosinopril sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The possibility of hypotensive effects can be minimized by either discontinuing the diuretic or increasing salt intake prior to initiation of treatment with fosinopril sodium.

Output: <diuretic, effect, fosinopril sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Potassium Supplements and Potassium-Sparing Diuretics: Fosinopril sodium can attenuate potassium loss caused by thiazide diuretics.

Output: <Fosinopril sodium, effect, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium.

Output: <ACE inhibitors, effect, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids: In a clinical pharmacology study, coadministration of an antacid (aluminum hydroxide, magnesium hydroxide, and simethicone) with fosinopril reduced serum levels and urinary excretion of fosinoprilat as compared with fosinopril administered alone, suggesting that antacids may impair absorption of fosinopril.

Output: <antacid, mechanism, fosinopril>, <aluminum hydroxide, mechanism, fosinopril>, <magnesium hydroxide, mechanism, fosinopril>, <simethicone, mechanism, fosinopril>, <antacids, mechanism, fosinopril>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drug Interactions: Flupenthixol may interact with some drugs, like Monoamine oxidase inhibitors (MAOI): MAOI could theoretically affect flupenthixol pharmacodynamics - Arecoline - Eproxindine - Ethanol: Flupenthixol and Ethanol cause additive CNS depression - Tricyclic antidepressants: Flupenthixol increases the effect of Tricyclic antidepressants

Output: <Flupenthixol, int, Monoamine oxidase inhibitors>, <Flupenthixol, int, MAOI>, <MAOI, effect, flupenthixol>, <Flupenthixol, effect, Ethanol>, <Flupenthixol, effect, Tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Curariform muscle relaxants (eg, tubocurarine) and other drugs, including ether, succinylcholine, gallamine, decamethonium and sodium citrate, potentiate the neuromuscular blocking effect and should be used with extreme caution in patients being treated with Coly-Mycin M Parenteral.

Output: <Curariform muscle relaxants, effect, Coly-Mycin M>, <tubocurarine, effect, Coly-Mycin M>, <succinylcholine, effect, Coly-Mycin M>, <gallamine, effect, Coly-Mycin M>, <decamethonium, effect, Coly-Mycin M>, <sodium citrate, effect, Coly-Mycin M>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sodium cephalothin may enhance the nephrotoxicity of Coly-Mycin M Parenteral.

Output: <Sodium cephalothin, effect, Coly-Mycin M>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant use of sodium cephalothin and Coly-Mycin M Parenteral should be avoided.

Output: <sodium cephalothin, advise, Coly-Mycin M>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hypotension - Patients on Diuretic Therapy: Patients on diuretics, and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with PRINIVIL.

Output: <diuretics, effect, PRINIVIL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The possibility of hypotensive effects with PRINIVIL can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with PRINIVIL.

Output: <diuretic, effect, PRINIVIL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If it is necessary to continue the diuretic, initiate therapy with PRINIVIL at a dose of 5 mg daily, and provide close medical supervision after the initial dose until blood pressure has stabilized.

Output: <diuretic, advise, PRINIVIL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When a diuretic is added to the therapy of a patient receiving PRINIVIL, an additional antihypertensive effect is usually observed.

Output: <diuretic, effect, PRINIVIL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Studies with ACE inhibitors in combination with diuretics indicate that the dose of the ACE inhibitor can be reduced when it is given with a diuretic.

Output: <ACE inhibitor, advise, diuretic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Non-steroidal Anti-inflammatory Agents: In some patients with compromised renal function who are being treated with non-steroidal anti-inflammatory drugs, the co-administration of lisinopril may result in a further deterioration of renal function.

Output: <non-steroidal anti-inflammatory drugs, effect, lisinopril>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors, including lisinopril.

Output: <NSAIDs, effect, ACE inhibitors>, <NSAIDs, effect, lisinopril>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE inhibitors.

Output: <NSAIDs, advise, ACE inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Agents Increasing Serum Potassium: PRINIVIL attenuates potassium loss caused by thiazide-type diuretics.

Output: <PRINIVIL, effect, thiazide-type diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Use of PRINIVIL with potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.

Output: <PRINIVIL, effect, potassium-sparing diuretics>, <PRINIVIL, effect, spironolactone>, <PRINIVIL, effect, triamterene>, <PRINIVIL, effect, amiloride>, <PRINIVIL, effect, potassium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors.

Output: <lithium, effect, ACE inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium toxicity was usually reversible upon discontinuation of lithium and the ACE inhibitor.

Output: <lithium, effect, ACE inhibitor>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended that serum lithium levels be monitored frequently if PRINIVIL is administered concomitantly with lithium.

Output: <PRINIVIL, advise, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The CNS effects of butalbital may be enhanced by monoamine oxidase (MAO) inhibitors.

Output: <butalbital, effect, monoamine oxidase (MAO) inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Butalbital, acetaminophen and caffeine may enhance the effects of: other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression.

Output: <Butalbital, effect, narcotic analgesic>, <Butalbital, effect, alcohol>, <Butalbital, effect, anesthetics>, <Butalbital, effect, tranquilizers>, <Butalbital, effect, chlordiazepoxide>, <Butalbital, effect, sedative-hypnotics>, <Butalbital, effect, CNS depressants>, <acetaminophen, effect, narcotic analgesic>, <acetaminophen, effect, alcohol>, <acetaminophen, effect, anesthetics>, <acetaminophen, effect, tranquilizers>, <acetaminophen, effect, chlordiazepoxide>, <acetaminophen, effect, sedative-hypnotics>, <acetaminophen, effect, CNS depressants>, <caffeine, effect, narcotic analgesic>, <caffeine, effect, alcohol>, <caffeine, effect, anesthetics>, <caffeine, effect, tranquilizers>, <caffeine, effect, chlordiazepoxide>, <caffeine, effect, sedative-hypnotics>, <caffeine, effect, CNS depressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: CNS-Active Drugs Ethanol: Sonata 10 mg potentiated the CNS-impairing effects of ethanol 0.75 g/kg on balance testing and reaction time for 1 hour after ethanol administration and on the digit symbol substitution test (DSST), symbol copying test, and the variability component of the divided attention test for 2.5 hours after ethanol administration.

Output: <Sonata, effect, ethanol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Imipramine: Coadministration of single doses of Sonata 20 mg and imipramine 75 mg produced additive effects on decreased alertness and impaired psychomotor performance for 2 to 4 hours after administration.

Output: <Sonata, effect, imipramine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thioridazine: Coadministration of single doses of Sonata 20 mg and thioridazine 50 mg produced additive effects on decreased alertness and impaired psychomotor performance for 2 to 4 hours after administration.

Output: <Sonata, effect, thioridazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Promethazine: Coadministration of a single dose of zaleplon and promethazine (10 and 25 mg, respectively) resulted in a 15% decrease in maximal plasma concentrations of zaleplon, but no change in the area under the plasma concentration-time curve.

Output: <zaleplon, mechanism, promethazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Multiple-dose administration of the potent CYP3A4 inducer rifampin (600 mg every 24 hours, q24h, for 14 days), however, reduced zaleplon Cmax and AUC by approximately 80%.

Output: <rifampin, mechanism, zaleplon>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of single, oral doses of zaleplon with erythromycin (10 mg and 800 mg, respectively), a strong, selective CYP3A4 inhibitor produced a 34% increase in zaleplons maximal plasma concentrations and a 20% increase in the area under the plasma concentration-time curve.

Output: <zaleplon, mechanism, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other strong selective CYP3A4 inhibitors such as ketoconazole can also be expected to increase the exposure of zaleplon.

Output: <ketoconazole, mechanism, zaleplon>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs That Inhibit Both Aldehyde Oxidase and CYP3A4 Cimetidine: Cimetidine inhibits both aldehyde oxidase (in vitro) and CYP3A4 (in vitro and in vivo), the primary and secondary enzymes, respectively, responsible for zaleplon metabolism.

Output: <Cimetidine, mechanism, zaleplon>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of Sonata (10 mg) and cimetidine (800 mg) produced an 85% increase in the mean Cmax and AUC of zaleplon.

Output: <Sonata, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A pharmacokinetic study evaluating the administration of a single dose of INSPRA 100 mg with ketoconazole 200 mg BID, a potent inhibitor of the CYP3A4 pathway, showed a 1.7-fold increase in Cmax of eplerenone and a 5.4-fold increase in AUC of eplerenone.

Output: <INSPRA, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of eplerenone with other CYP3A4 inhibitors (e.g., erythromycin 500 mg BID, verapamil 240 mg QD, saquinavir 1200 mg TID, fluconazole 200 mg QD) resulted in increases in Cmax of eplerenone ranging from 1.4- to 1.6- fold and AUC from 2.0- to 2.9- fold.

Output: <eplerenone, mechanism, erythromycin>, <eplerenone, mechanism, verapamil>, <eplerenone, mechanism, saquinavir>, <eplerenone, mechanism, fluconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ACE Inhibitors and Angiotensin II Receptor Antagonists (Hypertension)- In clinical studies of patients with hypertension, the addition of INSPRA 50 to 100 mg to ACE inhibitors and angiotensin II receptor antagonists increased mean serum potassium slightly (about 0.09-0.13 mEq/L).

Output: <INSPRA, effect, ACE inhibitors>, <INSPRA, effect, angiotensin II receptor antagonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a study in diabetics with microalbuminuria INSPRA 200 mg combined with the ACE inhibitor enalapril 10 mg increased the frequency of hyperkalemia (serum potassium  5.5 mEq/L) from 17% on enalapril alone to 38%.

Output: <INSPRA, effect, enalapril>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Serum lithium levels should be monitored frequently if INSPRA is administered concomitantly with lithium.

Output: <INSPRA, advise, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The administration of other potassium-sparing antihypertensives with NSAIDs has been shown to reduce the antihypertensive effect in some patients and result in severe hyperkalemia in patients with impaired renal function.

Output: <potassium-sparing antihypertensives, effect, NSAIDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, when INSPRA and NSAIDs are used concomitantly, patients should be observed to determine whether the desired effect on blood pressure is obtained.

Output: <INSPRA, advise, NSAIDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aminoglutethimide: Aminoglutethimide may diminish adrenal suppression by corticosteroids.

Output: <Aminoglutethimide, effect, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Amphotericin B injection and potassium-depleting agents: When corticosteroids are administered concomitantly with potassium-depleting agents (e.g., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia.

Output: <corticosteroids, advise, amphotericin B>, <corticosteroids, advise, diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition, there have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure.

Output: <amphotericin B, effect, hydrocortisone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antibiotics: Macrolide antibiotics have been reported to cause a significant decrease in corticosteroid clearance.

Output: <Macrolide antibiotics, mechanism, corticosteroid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticholinesterases: Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis.

Output: <anticholinesterase agents, effect, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If possible, anticholinesterase agents should be withdrawn at least 24 hours before initiating corticosteroid therapy.

Output: <anticholinesterase agents, advise, corticosteroid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticoagulants, oral: Co-administration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports.

Output: <corticosteroids, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antidiabetics: Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required.

Output: <corticosteroids, effect, antidiabetic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cholestyramine: Cholestyramine may increase the clearance of corticosteroids.

Output: <Cholestyramine, mechanism, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently.

Output: <cyclosporine, effect, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ephedrine: Ephedrine may enhance the metabolic clearance of corticosteroids, resulting in decreased blood levels and lessened physiologic activity, thus requiring an increase in corticosteroid dosage.

Output: <Ephedrine, mechanism, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Estrogens, including oral contraceptives: Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect.

Output: <Estrogens, mechanism, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hepatic Enzyme Inducers, Inhibitors and Substrates: Drugs which induce cytochrome P450 3A4 (CYP 3A4) enzyme activity (e.g., barbiturates, phenytoin, carbamazepine, rifampin) may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased.

Output: <barbiturates, mechanism, corticosteroids>, <phenytoin, mechanism, corticosteroids>, <carbamazepine, mechanism, corticosteroids>, <rifampin, mechanism, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs which inhibit CYP 3A4 (e.g., ketoconazole, macrolide antibiotics such as erythromycin) have the potential to result in increased plasma concentrations of corticosteroids.

Output: <ketoconazole, mechanism, corticosteroids>, <macrolide antibiotics, mechanism, corticosteroids>, <erythromycin, mechanism, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: Ketoconazole has been reported to decrease the metabolism of certain corticosteroids by up to 60%, leading to increased risk of corticosteroid side effects.

Output: <Ketoconazole, mechanism, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition, ketoconazole alone can inhibit adrenal corticosteroid synthesis and may cause adrenal insufficiency during corticosteroid withdrawal.

Output: <ketoconazole, effect, corticosteroid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nonsteroidal anti-inflammatory agents (NSAIDS): Concomitant use of aspirin (or other nonsteroidal antiinflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects.

Output: <aspirin, effect, corticosteroids>, <nonsteroidal antiinflammatory agents, effect, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.

Output: <Aspirin, advise, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The clearance of salicylates may be increased with concurrent use of corticosteroids.

Output: <salicylates, mechanism, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin: In post-marketing experience, there have been reports of both increases and decreases in phenytoin levels with dexamethasone co-administration, leading to alterations in seizure control.

Output: <phenytoin, mechanism, dexamethasone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Vaccines: Patients on corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody response.

Output: <corticosteroid, effect, live vaccines>, <corticosteroid, effect, inactivated vaccines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines.

Output: <Corticosteroids, effect, live attenuated vaccines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Routine administration of vaccines or toxoids should be deferred until corticosteroid therapy is discontinued if possible.

Output: <vaccines, advise, corticosteroid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cytosine arabinoside, a cytostatic agent, has been reported to inactivate the antifungal activity of flucytosine by competitive inhibition.

Output: <Cytosine arabinoside, effect, flucytosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: THE POTENTIATING ACTION OF HYDROXYZINE MUST BE CONSIDERED WHEN THE DRUG IS USED IN CONJUNCTION WITH CENTRAL NERVOUS SYSTEM DEPRESSANTS SUCH AS NARCOTICS, NON-NARCOTIC ANALGESICS AND BARBITURATES.

Output: <HYDROXYZINE, effect, CENTRAL NERVOUS SYSTEM DEPRESSANTS>, <HYDROXYZINE, effect, NARCOTICS>, <HYDROXYZINE, effect, NON-NARCOTIC ANALGESICS>, <HYDROXYZINE, effect, BARBITURATES>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore when central nervous system depressants are administered concomitantly with hydroxyzine their dosage should be reduced.

Output: <central nervous system depressants, advise, hydroxyzine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Amantadine, tricyclic antidepressants, and MAOIs may increase anticholinergic effect of clidinium.

Output: <Amantadine, effect, clidinium>, <tricyclic antidepressants, effect, clidinium>, <MAOIs, effect, clidinium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Clidinium may decrease the effect of phenothiazines, levodopa, and ketoconazole.

Output: <Clidinium, effect, phenothiazines>, <Clidinium, effect, levodopa>, <Clidinium, effect, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

Output: <oxyphenbutazone, mechanism, androgens>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements.

Output: <androgens, effect, insulin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticonvulsants: In a pharmacokinetic study, maximum plasma concentrations of felodipine were considerably lower in epileptic patients on long-term anticonvulsant therapy (eg, phenytoin, carbamazepine, or phenobarbital) than in healthy volunteers.

Output: <felodipine, mechanism, anticonvulsant>, <felodipine, mechanism, phenytoin>, <felodipine, mechanism, carbamazepine>, <felodipine, mechanism, phenobarbital>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: As with other NSAIDs, concomitant administration of Ponstel and aspirin is not generally recommended because of the potential of increased adverse effects.

Output: <NSAIDs, advise, aspirin>, <Ponstel, advise, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methotrexate: NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices.

Output: <NSAIDs, mechanism, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be used when NSAIDs are administered concomitantly with methotrexate.

Output: <NSAIDs, advise, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors.

Output: <NSAIDs, effect, ACE inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE inhibitors.

Output: <NSAIDs, advise, ACE inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide: Clinical studies, as well as post-marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.

Output: <NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: During concomitant therapy of Ponstel with furosemide, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.

Output: <Ponstel, advise, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.

Output: <NSAIDs, mechanism, lithium>, <NSAIDs, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Output: <NSAIDs, advise, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.

Output: <warfarin, effect, NSAIDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids: In a single dose study (n=6), ingestion of an antacid containing 1.7-gram of magnesium hydroxide with 500-mg of mefenamic acid increased the Cmax and AUC of mefenamic acid by 125% and 36%, respectively.  A number of compounds are inhibitors of CYP2C9 including fluconazole, lovastatin and trimethoprim.

Output: <magnesium hydroxide, mechanism, mefenamic acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oral Anticoagulants: In some normal volunteers, the concomitant administration of diflunisal and warfarin, acenocoumarol, or phenprocoumon resulted in prolongation of prothrombin time.

Output: <diflunisal, effect, warfarin>, <diflunisal, effect, acenocoumarol>, <diflunisal, effect, phenprocoumon>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This may occur because diflunisal competitively displaces coumarins from protein binding sites.

Output: <diflunisal, mechanism, coumarins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Accordingly, when diflunisal is administered with oral anticoagulants, the prothrombin time should be closely monitored during and for several days after concomitant drug administration.

Output: <diflunisal, advise, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hydrochlorothiazide: In normal volunteers, concomitant administration of diflunisal and hydrochlorothiazide resulted in significantly increased plasma levels of hydrochlorothiazide.

Output: <diflunisal, mechanism, hydrochlorothiazide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diflunisal decreased the hyperuricemic effect of hydrochlorothiazide.

Output: <Diflunisal, effect, hydrochlorothiazide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diflunisal decreased the hyperuricemic effect of furosemide.

Output: <Diflunisal, effect, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids: Concomitant administration of antacids may reduce plasma levels of diflunisal.

Output: <antacids, mechanism, diflunisal>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetaminophen: In normal volunteers, concomitant administration of diflunisal and acetaminophen resulted in an approximate 50% increase in plasma levels of acetaminophen.

Output: <diflunisal, mechanism, acetaminophen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since acetaminophen in high doses has been associated with hepatotoxicity, concomitant administration of diflunisal and acetaminophen should be used cautiously, with careful monitoring of patients.

Output: <diflunisal, advise, acetaminophen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of diflunisal and acetaminophen in dogs, but not in rats, at approximately 2 times the recommended maximum human therapeutic dose of each (40 to 52 mg/kg/day of diflunisal/acetaminophen) resulted in greater gastrointestinal toxicity than when either drug was administered alone.

Output: <diflunisal, effect, acetaminophen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methotrexate: Caution should be used if diflunisal is administered concomitantly with methotrexate.

Output: <diflunisal, advise, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nonsteroidal anti-inflammatory drugs have been reported to decrease the tubular secretion of methotrexate and to potentiate its toxicity.

Output: <Nonsteroidal anti-inflammatory drugs, mechanism, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporine: Administration of nonsteroial anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin.

Output: <nonsteroial anti-inflammatory drugs, mechanism, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored.

Output: <NSAIDs, advise, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nonsteroidal Anti-Inflammatory Drugs: The administration of diflunisal to normal volunteers receiving indomethacin decreased the renal clearance and significantly increased the plasma levels of indomethacin.

Output: <diflunisal, mechanism, indomethacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In some patients the combined use of indomethacin and diflunisal has been associated with fatal gastrointestinal hemorrhage.

Output: <indomethacin, effect, diflunisal>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, indomethacin and diflunisal should not be used concomitantly.

Output: <indomethacin, advise, diflunisal>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant use of diflunisal tablets and other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy.

Output: <diflunisal, effect, NSAIDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: In normal volunteers, a small decrease in diflunisal levels was observed when multiple doses of diflunisal and aspirin were administered concomitantly.

Output: <diflunisal, mechanism, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sulindac: The concomitant administration of diflunisal and sulindac in normal volunteers resulted in lowering of the plasma levels of the active sulindac sulfide metabolite by approximately one-third.

Output: <diflunisal, mechanism, sulindac>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Naproxen: The concomitant administration of diflunisal and naproxen in normal volunteers had no effect on the plasma levels of naproxen, but significantly decreased the urinary excretion of naproxen and its glucuronide metabolite.

Output: <diflunisal, mechanism, naproxen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lincomycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents.

Output: <Lincomycin, effect, neuromuscular blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antagonism between lincomycin and erythromycin in vitro has been demonstrated.

Output: <lincomycin, effect, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Careful observation is required when amantadine is administered concurrently with central nervous system stimulants.

Output: <amantadine, advise, central nervous system stimulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since Zarontin (ethosuximide) may interact with concurrently administered antiepileptic drugs, periodic serum level determinations of these drugs may be necessary (eg, ethosuximide may elevate phenytoin serum levels and valproic acid has been reported to both increase and decrease ethosuximide levels).

Output: <Zarontin, int, antiepileptic drugs>, <ethosuximide, int, antiepileptic drugs>, <ethosuximide, mechanism, phenytoin>, <valproic acid, mechanism, ethosuximide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of 0.1-mg/kg (2 x ED95) NIMBEX at 10% or 95% recovery following an intubating dose of succinylcholine (1 mg/kg) produced  95% neuromuscular block.

Output: <NIMBEX, effect, succinylcholine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The time to onset of maximum block following NIMBEX is approximately 2 minutes faster with prior administration of succinylcholine.

Output: <NIMBEX, effect, succinylcholine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Infusion requirements of NIMBEX in patients administered succinylcholine prior to infusions of NIMBEX were comparable to or slightly greater than when succinylcholine was not administered.

Output: <succinylcholine, effect, NIMBEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Isoflurane or enflurane administered with nitrous oxide/oxygen to achieve 1.25 MAC [Minimum Alveolar Concentration] may prolong the clinically effective duration of action of initial and maintenance doses of NIMBEX and decrease the required infusion rate of NIMBEX.

Output: <Isoflurane, effect, NIMBEX>, <Isoflurane, effect, NIMBEX>, <enflurane, effect, NIMBEX>, <enflurane, effect, NIMBEX>, <nitrous oxide, effect, NIMBEX>, <nitrous oxide, effect, NIMBEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In long surgical procedures during enflurane or isoflurane anesthesia, less frequent maintenance dosing, lower maintenance doses, or reduced infusion rates of NIMBEX may be necessary.

Output: <enflurane, advise, NIMBEX>, <isoflurane, advise, NIMBEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other drugs which may enhance the neuromuscular blocking action of nondepolarizing agents such as NIMBEX include certain antibiotics (e. g., aminoglycosides, tetracyclines, bacitracin, polymyxins, lincomycin, clindamycin, colistin, and sodium colistemethate), magnesium salts, lithium, local anesthetics, procainamide, and quinidine.

Output: <nondepolarizing agents, effect, NIMBEX>, <nondepolarizing agents, effect, antibiotics>, <nondepolarizing agents, effect, aminoglycosides>, <nondepolarizing agents, effect, tetracyclines>, <nondepolarizing agents, effect, bacitracin>, <nondepolarizing agents, effect, polymyxins>, <nondepolarizing agents, effect, lincomycin>, <nondepolarizing agents, effect, clindamycin>, <nondepolarizing agents, effect, colistin>, <nondepolarizing agents, effect, sodium colistemethate>, <nondepolarizing agents, effect, magnesium>, <nondepolarizing agents, effect, lithium>, <nondepolarizing agents, effect, anesthetics>, <nondepolarizing agents, effect, procainamide>, <nondepolarizing agents, effect, quinidine>, <NIMBEX, effect, antibiotics>, <NIMBEX, effect, aminoglycosides>, <NIMBEX, effect, tetracyclines>, <NIMBEX, effect, bacitracin>, <NIMBEX, effect, polymyxins>, <NIMBEX, effect, lincomycin>, <NIMBEX, effect, clindamycin>, <NIMBEX, effect, colistin>, <NIMBEX, effect, sodium colistemethate>, <NIMBEX, effect, magnesium>, <NIMBEX, effect, lithium>, <NIMBEX, effect, anesthetics>, <NIMBEX, effect, procainamide>, <NIMBEX, effect, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Resistance to the neuromuscular blocking action of nondepolarizing neuromuscular blocking agents has been demonstrated in patients chronically administered phenytoin or carbamazepine.

Output: <nondepolarizing neuromuscular blocking agents, effect, phenytoin>, <nondepolarizing neuromuscular blocking agents, effect, carbamazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: While the effects of chronic phenytoin or carbamazepine therapy on the action of NIMBEX are unknown, slightly shorter durations of neuromuscular block may be anticipated and infusion rate requirements may be higher.

Output: <phenytoin, effect, NIMBEX>, <carbamazepine, effect, NIMBEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Starlix is a potential inhibitor of the CYP2C9 isoenzyme in vivo as indicated by its ability to inhibit the in vitro metabolism of tolbutamide.

Output: <Starlix, mechanism, tolbutamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Certain drugs, including nonsteroidal anti-inflammatory agents (NSAIDs), salicylates, monoamine oxidase inhibitors, and non-selective beta-adrenergic-blocking agents may potentiate the hypoglycemic action of Starlix and other oral antidiabetic drugs.

Output: <nonsteroidal anti-inflammatory agents, effect, Starlix>, <nonsteroidal anti-inflammatory agents, effect, antidiabetic drugs>, <NSAIDs, effect, Starlix>, <NSAIDs, effect, antidiabetic drugs>, <salicylates, effect, Starlix>, <salicylates, effect, antidiabetic drugs>, <monoamine oxidase inhibitors, effect, Starlix>, <monoamine oxidase inhibitors, effect, antidiabetic drugs>, <non-selective beta-adrenergic-blocking agents, effect, Starlix>, <non-selective beta-adrenergic-blocking agents, effect, antidiabetic drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Certain drugs including thiazides, corticosteroids, thyroid products, and sympathomimetics may reduce the hypoglycemic action of Starlix and other oral antidiabetic drugs.

Output: <thiazides, effect, Starlix>, <thiazides, effect, antidiabetic drugs>, <corticosteroids, effect, Starlix>, <corticosteroids, effect, antidiabetic drugs>, <thyroid products, effect, Starlix>, <thyroid products, effect, antidiabetic drugs>, <sympathomimetics, effect, Starlix>, <sympathomimetics, effect, antidiabetic drugs>