Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nabilone has been shown to have an additive CNS depressant effect when given with either diazepam, secobarbitone sodium, alcohol or codeine.

Output: <Nabilone, effect, diazepam>, <Nabilone, effect, secobarbitone sodium>, <Nabilone, effect, alcohol>, <Nabilone, effect, codeine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin, Digoxin, Salicylate, and Heparin The in vitro binding of warfarin to plasma proteins is only slightly reduced by ketorolac tromethamine (99.5% control vs 99.3%) when ketorolac plasma concentrations reach 5 to10 m g/mL.

Output: <warfarin, mechanism, ketorolac tromethamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In vitro studies indicate that, at therapeutic concentrations of salicylate (300 m g/mL), the binding of ketorolac was reduced from approximately 99.2% to 97.5%, representing a potential twofold increase in unbound ketorolac plasma levels.

Output: <salicylate, mechanism, ketorolac>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although these results do not indicate a significant interaction between TORADOL and warfarin or heparin, the administration of TORADOL to patients taking anticoagulants should be done extremely cautiously, and patients should be closely monitored.

Output: <TORADOL, advise, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide: TORADOL IV/IM reduced the diuretic response to furosemide in normovolemic healthy subjects by approximately 20% (mean sodium and urinary output decreased 17%).

Output: <TORADOL, effect, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid: Concomitant administration of TORADOL ORAL and probenecid resulted in decreased clearance of ketorolac and significant increases in ketorolac plasma levels (total AUC increased approximately threefold from 5.4 to 17.8 m g/h/mL) and terminal half-life increased approximately twofold from 6.6 to 15.1 hours.

Output: <TORADOL, mechanism, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, concomitant use of TORADOL and probenecid is contraindicated.

Output: <TORADOL, advise, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The effect of TORADOL on plasma lithium has not been studied, but cases of increased lithium plasma levels during TORADOL therapy have been reported.

Output: <lithium, mechanism, TORADOL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methotrexate: Concomitant administration of methotrexate and some NSAIDs has been reported to reduce the clearance of methotrexate, enhancing the toxicity of methotrexate.

Output: <methotrexate, mechanism, NSAIDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antiepileptic Drugs: Sporadic cases of seizures have been reported during concomitant use of TORADOL and antiepileptic drugs (phenytoin, carbamazepine).

Output: <TORADOL, effect, antiepileptic drugs>, <TORADOL, effect, phenytoin>, <TORADOL, effect, carbamazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Psychoactive Drugs: Hallucinations have been reported when TORADOL was used in patients taking psychoactive drugs (fluoxetine, thiothixene, alprazolam).

Output: <TORADOL, effect, psychoactive drugs>, <TORADOL, effect, fluoxetine>, <TORADOL, effect, thiothixene>, <TORADOL, effect, alprazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ethoxzolamide may increase the action of tricyclics, amphetamines, procainamide, and quinidine.

Output: <Ethoxzolamide, effect, tricyclics>, <Ethoxzolamide, effect, amphetamines>, <Ethoxzolamide, effect, procainamide>, <Ethoxzolamide, effect, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of ethoxzolamide with other diuretics, amphotericin B, and corticosteroids may cause hypokalemia.

Output: <ethoxzolamide, effect, diuretics>, <ethoxzolamide, effect, amphotericin B>, <ethoxzolamide, effect, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with ACE inhibitors, and with some angiotensin II receptor antagonists.

Output: <lithium, mechanism, ACE inhibitors>, <lithium, mechanism, angiotensin II receptor antagonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: An increase in serum lithium concentration has been reported during concomitant administration of lithium with ATACAND, so careful monitoring of serum lithium levels is recommended during concomitant use.

Output: <lithium, mechanism, ATACAND>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Repeated doses of colestipol hydrochloride given prior to a single dose of propranolol in human trials have been reported to decrease propranolol absorption.

Output: <colestipol hydrochloride, mechanism, propranolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, patients on propranolol should be observed when COLESTID Tablets are either added or deleted from a therapeutic regimen.

Output: <propranolol, advise, COLESTID>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Studies in humans show that the absorption of chlorothiazide as reflected in urinary excretion is markedly decreased even when administered one hour before colestipol hydrochloride.

Output: <chlorothiazide, mechanism, colestipol hydrochloride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride;

Output: <tetracycline, mechanism, colestipol hydrochloride>, <furosemide, mechanism, colestipol hydrochloride>, <penicillin G, mechanism, colestipol hydrochloride>, <hydrochlorothiazide, mechanism, colestipol hydrochloride>, <gemfibrozil, mechanism, colestipol hydrochloride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Particular caution should be observed with digitalis preparations since there are conflicting results for the effect of colestipol hydrochloride on the availability of digoxin and digitoxin.

Output: <digitalis preparations, effect, colestipol hydrochloride>, <colestipol hydrochloride, mechanism, digoxin>, <colestipol hydrochloride, mechanism, digitoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Bile acid binding resins may also interfere with the absorption of oral phosphate supplements and hydrocortisone.

Output: <Bile acid binding resins, mechanism, phosphate>, <Bile acid binding resins, mechanism, hydrocortisone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Benzthiazide may interact with alcohol, blood thinners, decongestant drugs (allergy, cold, and sinus medicines), diabetic drugs, lithium, norepinephrine, NSAIDs like Aleve or Ibuprofen, and high blood pressure medications.

Output: <Benzthiazide, int, alcohol>, <Benzthiazide, int, blood thinner>, <Benzthiazide, int, decongestant drugs>, <Benzthiazide, int, lithium>, <Benzthiazide, int, norepinephrine>, <Benzthiazide, int, NSAIDs>, <Benzthiazide, int, Aleve>, <Benzthiazide, int, Ibuprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The risk of using bromocriptine mesylate in combination with other drugs has not been systematically evaluated, but alcohol may potentiate the side effects of bromocriptine mesylate.

Output: <alcohol, effect, bromocriptine mesylate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Bromocriptine mesylate may interact with dopamine antagonists, butyrophenones, and certain other agents.

Output: <Bromocriptine mesylate, int, dopamine antagonists>, <Bromocriptine mesylate, int, butyrophenones>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Compounds in these categories result in a decreased efficacy of bromocriptine mesylate: phenothiazines, haloperidol, metoclopramide, pimozide.

Output: <bromocriptine mesylate, effect, phenothiazines>, <bromocriptine mesylate, effect, haloperidol>, <bromocriptine mesylate, effect, metoclopramide>, <bromocriptine mesylate, effect, pimozide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of bromocriptine mesylate with other ergot alkaloids is not recommended.

Output: <bromocriptine mesylate, advise, ergot alkaloids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, linezolid has the potential for interaction with adrenergic and serotonergic agents.

Output: <linezolid, int, adrenergic>, <linezolid, int, serotonergic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Adrenergic Agents:Some individuals receiving ZYVOX may experience a reversible enhancement of the pressor response to indirect-acting sympathomimetic agents, vasopressor or dopaminergic agents.

Output: <ZYVOX, effect, sympathomimetic agents>, <ZYVOX, effect, vasopressor>, <ZYVOX, effect, dopaminergic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Spontaneous reports of serotonin syndrome associated with co-administration of ZYVOX and serotonergic agents, including antidepressants such as selective serotonin reuptake inhibitors (SSRIs), have been reported.

Output: <ZYVOX, effect, serotonergic agents>, <ZYVOX, effect, antidepressants>, <ZYVOX, effect, selective serotonin reuptake inhibitors>, <ZYVOX, effect, SSRIs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients who are treated with ZYVOX and concomitant serotonergic agents should be closely observed for signs and symptoms of serotonin syndrome (e.g., cognitive dysfunction, hyperpyrexia, hyperreflexia, incoordination).

Output: <ZYVOX, effect, serotonergic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If any signs or symptoms occur physicians should consider discontinuation of either one or both agents (ZYVOX or concomitant serotonergic agents).

Output: <ZYVOX, advise, serotonergic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coumarin Anticoagulants Altered coagulation parameters and/or bleeding have been reported in patients taking capecitabine concomitantly with coumarin-derivative anticoagulants such as warfarin and phenprocoumon.

Output: <capecitabine, effect, coumarin-derivative anticoagulants>, <capecitabine, effect, phenprocoumon>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients taking coumarin-derivative anticoagulants concomitantly with capecitabine should be monitored regularly for alterations in their coagulation parameters (PT or INR).

Output: <coumarin-derivative anticoagulants, advise, capecitabine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Leucovorin: The concentration of 5-fluorouracil is increased and its toxicity may be enhanced by leucovorin.

Output: <5-fluorouracil, mechanism, leucovorin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Deaths from severe enterocolitis, diarrhea, and dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil.

Output: <leucovorin, effect, fluorouracil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The rate of metabolism and the leukopenic activity of cyclophosphamide reportedly are increased by chronic administration of high doses of phenobarbital.

Output: <cyclophosphamide, mechanism, phenobarbital>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclophosphamide treatment, which causes a marked and persistent inhibition of cholinesterase activity, potentiates the effect of succinylcholine chloride.

Output: <Cyclophosphamide, effect, succinylcholine chloride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Iodine or iodine excess may decrease the effect of Carbimazole, and an iodine deficiency can increase the effect of Carbimazole.

Output: <Iodine, effect, Carbimazole>, <iodine, effect, Carbimazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Serum concentration of digoxin and digitoxin may increase when patients take antithyroid agents.

Output: <digoxin, mechanism, antithyroid agents>, <digitoxin, mechanism, antithyroid agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antithyroid agents may decrease thyroidal uptake of sodium iodide I131, a rebound in uptake may occur up to 5 days after sudden withdrawal of Carbimazole.

Output: <Antithyroid agents, effect, sodium iodide I131>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Based on anecdotal reports, there may be an interaction between buprenorphine and benzodiazepines.

Output: <buprenorphine, int, benzodiazepines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been a number of reports in the post-marketing experience of coma and death associated with the concomitant intravenous misuse of buprenorphine and benzodiazepines by addicts.

Output: <buprenorphine, effect, benzodiazepines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: SUBUTEX and SUBOXONE should be prescribed with caution to patients on benzodiazepines or other drugs that act on the central nervous system, regardless of whether these drugs are taken on the advice of a physician or are taken as drugs of abuse.

Output: <SUBUTEX, advise, benzodiazepines>, <SUBOXONE, advise, benzodiazepines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients should be warned of the potential danger of the intravenous self-administration of benzodiazepines while under treatment with SUBOXONE or SUBUTEX.

Output: <benzodiazepines, advise, SUBOXONE>, <benzodiazepines, advise, SUBUTEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Blood levels of hydrodolasetron increased 24% when dolasetron was coadministered with cimetidine (nonselective inhibitor of cytochrome P-450) for 7 days, and decreased 28% with coadministration of rifampin (potent inducer of cytochrome P-450) for 7 days.

Output: <dolasetron, mechanism, cimetidine>, <dolasetron, mechanism, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Clearance of hydrodolasetron decreased by about 27% when dolasetron mesylate was administered intravenously concomitantly with atenolol.

Output: <dolasetron mesylate, mechanism, atenolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chlorprothixene may increase the plasma-level of concomitantly given lithium.

Output: <Chlorprothixene, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If chlorprothixene is given concomitantly with opioids, the opioid dose should be reduced (by approx. 50%), because chlorprothixene amplifies the therapeutic actions and side-effects of opioids massively.

Output: <chlorprothixene, advise, opioids>, <chlorprothixene, effect, opioids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Avoid the concomitant use of chlorprothixene and tramadol (Ultram).

Output: <chlorprothixene, advise, tramadol>, <chlorprothixene, advise, Ultram>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Consider additive sedative effects and confusional states to emerge, if chlorprothixene is given with benzodiazepines or barbituates.

Output: <chlorprothixene, effect, benzodiazepines>, <chlorprothixene, effect, barbituates>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Exert particular caution in combining chlorprothixene with other anticholinergic drugs (tricyclic antidepressants and antiparkinsonian agents): Particularly the elderly may develop delirium, high fever, severe obstipation, even ileus and glaucoma.

Output: <chlorprothixene, advise, anticholinergic drugs>, <chlorprothixene, advise, tricyclic antidepressants>, <chlorprothixene, advise, antiparkinsonian agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Use in Conjunction with Other Antiepileptic Drugs: The addition of Felbatol  to antiepileptic drugs (AEDs) affects the steady-state plasma concentrations of AEDs.

Output: <Felbatol, mechanism, antiepileptic drugs>, <Felbatol, mechanism, AEDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Specific Effects of Felbatol  on Other Antiepileptic Drugs Phenytoin: Felbatol  causes an increase in steady-state phenytoin plasma concentrations.

Output: <Felbatol, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Increasing the felbamate dose to 1800 mg/day in six of these subjects increased the steady-state phenytoin Cmin to 25 7 micrograms/mL.

Output: <felbamate, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In order to maintain phenytoin levels, limit adverse experiences, and achieve the felbamate dose of 3600 mg/day, a phenytoin dose reduction of approximately 40% was necessary for eight of these 10 subjects.

Output: <felbamate, advise, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Carbamazepine: Felbatol  causes a decrease in the steady-state carbamazepine plasma concentrations and an increase in the steady-state carbamazepine epoxide plasma concentration.

Output: <Felbatol, mechanism, carbamazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The carbamazepine steady-state Cmin decreased 31% to 5 1 micrograms/mL when felbamate (3000 mg/day, divided into three doses) was coadministered.

Output: <carbamazepine, mechanism, felbamate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Valproate: Felbatol  causes an increase in steady-state valproate concentrations.

Output: <Felbatol, mechanism, valproate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Increasing the felbamate dose to 2400 mg/day increased the steadystate valproate Cmin to 96 25 micrograms/mL.

Output: <felbamate, mechanism, valproate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenobarbital: Coadministration of felbamate with phenobarbital causes an increase in phenobarbital plasma concentrations, In 12 otherwise healthy male volunteers ingesting phenobarbital, the steady-state trough (Cmin) phenobarbital concentration was 14.2 micrograms/mL.

Output: <felbamate, mechanism, phenobarbital>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Effects of Other Antiepileptic Drugs on Felbatol  Phenytoin: Phenytoin causes an approximate doubling of the clearance of Felbatol  (felbamate) at steady state and, therefore, the addition of phenytoin causes an approximate 45% decrease in the steady-state trough concentrations of Felbatol  as compared to the same dose of Felbatol  given as monotherapy.

Output: <Phenytoin, mechanism, Felbatol>, <Phenytoin, mechanism, felbamate>, <phenytoin, mechanism, Felbatol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Carbamazepine: Carbamazepine causes an approximate 50% increase in the clearance of Felbatol  at steady state and, therefore, the addition of carbamazepine results in an approximate 40% decrease in the steady-state trough concentrations of Felbatol  as compared to the same dose of Felbatol  given as monotherapy.

Output: <Carbamazepine, mechanism, Felbatol>, <carbamazepine, mechanism, Felbatol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenobarbital: It appears that phenobarbital may reduce plasma felbamate concentrations.

Output: <phenobarbital, mechanism, felbamate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Felbamate treatment resulted in a 42% decrease in the gestodene AUC 0-24, but no clinically relevant effect was observed on the pharmacokinetic parameters of ethinyl estradiol.

Output: <Felbamate, mechanism, gestodene>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chirocaine   should be used with caution in patients receiving other local anesthetics or agents structurally related to amide-type local anesthetics since the toxic effects of these drugs could be additive.

Output: <Chirocaine, advise, anesthetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although no clinical studies have been conducted, it is likely that the metabolism of levobupivacaine may be affected by the known CYP3A4 inducers (such as phenytoin, phenobarbital, rifampin), CYP3A4 inhibitors (azole antimycotics e.g., ketoconazole;

Output: <levobupivacaine, mechanism, phenytoin>, <levobupivacaine, mechanism, phenobarbital>, <levobupivacaine, mechanism, rifampin>, <levobupivacaine, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin.

Output: <aspirin, mechanism, ketoprofen>, <aspirin, mechanism, ketoprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, concurrent use of aspirin and ketoprofen is not recommended.

Output: <aspirin, advise, ketoprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone.

Output: <Hydrochlorothiazide, effect, ketoprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs.

Output: <ketoprofen, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding.

Output: <Probenecid, mechanism, ketoprofen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, the combination of ketoprofen and probenecid is not recommended.

Output: <ketoprofen, advise, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity.

Output: <Ketoprofen, mechanism, methotrexate>, <NSAIDs, mechanism, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels.

Output: <Nonsteroidal anti-inflammatory agents, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium.

Output: <ketoprofen, advise, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Interactions for Vitamin B3 (Niacin): Antihypertensive Therapy: Nicotinic acid may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension.

Output: <Nicotinic acid, effect, ganglionic blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: Concomitant aspirin may decrease the metabolic clearance of nicotinic acid.

Output: <aspirin, mechanism, nicotinic acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of irbesartan reduced aliskiren Cmax up to 50% after multiple dosing.

Output: <irbesartan, mechanism, aliskiren>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of atorvastatin resulted in about a 50% increase in aliskiren Cmax and AUC after multiple dosing.

Output: <atorvastatin, mechanism, aliskiren>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: Co-administration of 200 mg twice-daily ketoconazole with aliskiren resulted in an approximate 80% increase in plasma levels of aliskiren.

Output: <ketoconazole, mechanism, aliskiren>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide: When aliskiren was co-administered with furosemide, the AUC and Cmax of furosemide were reduced by about 30% and 50%, respectively.

Output: <aliskiren, mechanism, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acetaminophen: May increase plasma concentration of synthetic estrogens, possibly by inhibiting conjugation.

Output: <Acetaminophen, mechanism, synthetic estrogens>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Combination hormonal contraceptives may also decrease the plasma concentration of acetaminophen.

Output: <hormonal contraceptives, mechanism, acetaminophen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acitretin: Interferes with the contraceptive effect of microdosed progestin-containing minipill preparations.

Output: <Acitretin, effect, progestin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aminoglutethimide: May increase CYP metabolism of progestins leading to possible decrease in contraceptive effectiveness.

Output: <Aminoglutethimide, mechanism, progestins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticoagulants: Combination hormonal contraceptives may increase or decrease the effects of coumarin derivatives.

Output: <hormonal contraceptives, effect, coumarin derivatives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticonvulsants (carbamazepine, felbamate, phenobarbital, phenytoin, topiramate): Increase the metabolism of ethinyl estradiol and/or some progestins, leading to possible decrease in contraceptive effectiveness.

Output: <Anticonvulsants, mechanism, ethinyl estradiol>, <Anticonvulsants, mechanism, progestins>, <carbamazepine, mechanism, ethinyl estradiol>, <carbamazepine, mechanism, progestins>, <felbamate, mechanism, ethinyl estradiol>, <felbamate, mechanism, progestins>, <phenobarbital, mechanism, ethinyl estradiol>, <phenobarbital, mechanism, progestins>, <phenytoin, mechanism, ethinyl estradiol>, <phenytoin, mechanism, progestins>, <topiramate, mechanism, ethinyl estradiol>, <topiramate, mechanism, progestins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ascorbic acid: Doses of ascorbic acid (vitamin C) 1 g/day have been reported to increase plasma concentration of synthetic estrogens by ~47%, possibly by inhibiting conjugation;

Output: <ascorbic acid, mechanism, synthetic estrogens>, <vitamin C, mechanism, synthetic estrogens>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Atorvastatin: Atorvastatin increases the AUC for norethindrone and ethinyl estradiol.

Output: <Atorvastatin, mechanism, norethindrone>, <Atorvastatin, mechanism, ethinyl estradiol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Benzodiazepines: Combination hormonal contraceptives may decrease the clearance of some benzodiazepines (alprazolam, chlordiazepoxide, diazepam) and increase the clearance of others (lorazepam, oxazepam, temazepam).

Output: <hormonal contraceptives, mechanism, benzodiazepines>, <hormonal contraceptives, mechanism, alprazolam>, <hormonal contraceptives, mechanism, chlordiazepoxide>, <hormonal contraceptives, mechanism, diazepam>, <hormonal contraceptives, mechanism, lorazepam>, <hormonal contraceptives, mechanism, oxazepam>, <hormonal contraceptives, mechanism, temazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Clofibric acid: Combination hormonal contraceptives may increase the clearance of clofibric acid.

Output: <hormonal contraceptives, mechanism, clofibric acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporine: Combination hormonal contraceptives may inhibit the metabolism of cyclosporine, leading to increased plasma concentrations;

Output: <hormonal contraceptives, mechanism, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Griseofulvin: Griseofulvin may induce the metabolism of combination hormonal contraceptives causing menstrual changes;

Output: <Griseofulvin, mechanism, combination hormonal contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Morphine: Combination hormonal contraceptives may increase the clearance of morphine.

Output: <hormonal contraceptives, mechanism, morphine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Non-nucleoside reverse transcriptase inhibitors (NNRTIs): Nevirapine may decrease plasma levels of combination hormonal contraceptives;

Output: <Nevirapine, mechanism, combination hormonal contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Prednisolone: Ethinyl estradiol may inhibit the metabolism of prednisolone, leading to increased plasma concentrations.

Output: <Ethinyl estradiol, mechanism, prednisolone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Protease inhibitors: Amprenavir, lopinavir, nelfinavir, and ritonavir have been shown to decrease plasma levels of combination hormonal contraceptives;

Output: <Amprenavir, mechanism, combination hormonal contraceptives>, <lopinavir, mechanism, combination hormonal contraceptives>, <nelfinavir, mechanism, combination hormonal contraceptives>, <ritonavir, mechanism, combination hormonal contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Indinavir has been shown to increase plasma levels of combination hormonal contraceptives.

Output: <Indinavir, mechanism, combination hormonal contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rifampin: Rifampin increases the metabolism of ethinyl estradiol and some progestins (norethindrone) resulting in decreased contraceptive effectiveness and increased menstrual irregularities.

Output: <Rifampin, mechanism, ethinyl estradiol>, <Rifampin, mechanism, progestins>, <Rifampin, mechanism, norethindrone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Salicylic acid: Combination hormonal contraceptives may increase the clearance of salicylic acid.

Output: <hormonal contraceptives, mechanism, salicylic acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Selegiline: Combination hormonal contraceptives may increase the serum concentration of selegiline.

Output: <Combination hormonal contraceptives, mechanism, selegiline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Theophylline: Ethinyl estradiol may inhibit the metabolism of theophylline, leading to increased plasma concentrations.

Output: <Ethinyl estradiol, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tricyclic antidepressants (amitriptyline, imipramine, nortriptyline): Metabolism may be inhibited by combination hormonal contraceptives, increasing plasma levels of antidepressant;

Output: <Tricyclic antidepressants, mechanism, combination hormonal contraceptives>, <amitriptyline, mechanism, combination hormonal contraceptives>, <imipramine, mechanism, combination hormonal contraceptives>, <nortriptyline, mechanism, combination hormonal contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ETHANOL / NUTRITION / HERB INTERACTIONS: Food: CNS effects of caffeine may be enhanced if combination hormonal contraceptives are used concurrently with caffeine.

Output: <combination hormonal contraceptives, effect, caffeine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The response to Factrel may be blunted by phenothiazines and dopamine antagonists which cause a rise in prolactin.

Output: <Factrel, effect, phenothiazines>, <Factrel, effect, dopamine antagonists>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Diuretics: Patients on diuretics, especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with Lotensin.

Output: <diuretics, effect, Lotensin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The possibility of hypotensive effects with Lotensin can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with Lotensin.

Output: <diuretic, advise, Lotensin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Potassium Supplements and Potassium-Sparing Diuretics Lotensin can attenuate potassium loss caused by thiazide diuretics.

Output: <Potassium-Sparing Diuretics, effect, thiazide diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium.

Output: <ACE inhibitors, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If a diuretic is also used, the risk of lithium toxicity may be increased.

Output: <diuretic, effect, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Benazepril, like other ACE inhibitors, has had less than additive effects with beta-adrenergic blockers, presumably because both drugs lower blood pressure by inhibiting parts of the renin-angiotensin system

Output: <Benazepril, effect, beta-adrenergic blockers>, <ACE inhibitors, effect, beta-adrenergic blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Geocillin (carbenicillin indanyl sodium) blood levels may be increased and prolonged by concurrent administration of probenecid.

Output: <Geocillin, mechanism, probenecid>, <carbenicillin indanyl sodium, mechanism, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The hypoglycemic action of sulfonylurea may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents.

Output: <sulfonylurea, effect, nonsteroidal anti-inflammatory agents>, <sulfonylurea, effect, salicylates>, <sulfonylurea, effect, sulfonamides>, <sulfonylurea, effect, chloramphenicol>, <sulfonylurea, effect, probenecid>, <sulfonylurea, effect, coumarins>, <sulfonylurea, effect, monoamine oxidase inhibitors>, <sulfonylurea, effect, beta adrenergic blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since animal studies suggest that the action of barbiturates may be prolonged by therapy with chlorpropamide, barbiturates should be employed with caution.

Output: <barbiturates, effect, chlorpropamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported.

Output: <miconazole, effect, hypoglycemic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: Concomitant administration of aspirin with valdecoxib may result in an increased risk of GI ulceration and complications compared to valdecoxib alone.

Output: <aspirin, effect, valdecoxib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ACE-inhibitors:Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors.

Output: <NSAIDs, effect, ACE-inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This interaction should be given consideration in patients taking BEXTRA concomitantly with ACE-inhibitors.

Output: <BEXTRA, advise, ACE-inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide: Clinical studies, as well as post-marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.

Output: <NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticonvulsants (Phenytoin): Steady state plasma exposure (AUC) of valdecoxib (40 mg BID for 12 days) was decreased by 27% when co-administered with multiple doses (300 mg QD for 12 days) of phenytoin (a CYP 3A4 inducer).

Output: <valdecoxib, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients already stabilized on valdecoxib should be closely monitored for loss of symptom control with phenytoin coadministration.

Output: <valdecoxib, advise, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration with valdecoxib (40 mg BID for 7 days) resulted in a significant increase in dextromethorphan plasma levels suggesting that, at these doses, valdecoxib is a weak inhibitor of 2D6.

Output: <valdecoxib, mechanism, dextromethorphan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Even so dextromethorphan plasma concentrations in the presence of high doses of valdecoxib were almost 5-fold lower than those seen in CYP 2D6 poor metabolizers suggesting that dose adjustment is not necessary.

Output: <dextromethorphan, mechanism, valdecoxib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: Valdecoxib 40 mg BID for 7 days produced significant decreases in lithium serum clearance (25%) and renal clearance (30%) with a 34% higher serum exposure compared to lithium alone.

Output: <Valdecoxib, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium serum concentrations should be monitored closely when initiating or changing therapy with BEXTRA in patients receiving lithium.

Output: <BEXTRA, advise, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Valdecoxib caused a statistically significant increase in plasma exposures of R-warfarin and S-warfarin (12% and 15%, respectively), and in the pharmacodynamic effects (prothrombin time, measured as INR) of warfarin.

Output: <Valdecoxib, mechanism, R-warfarin>, <Valdecoxib, mechanism, S-warfarin>, <Valdecoxib, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticoagulant therapy should be monitored, particularly during the first few weeks, after initiating therapy with BEXTRA in patients receiving warfarin or similar agents.

Output: <BEXTRA, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant single dose administration of valdecoxib 20 mg with multiple doses of ketoconazole and fluconazole produced a significant increase in exposure of valdecoxib.

Output: <valdecoxib, mechanism, ketoconazole>, <valdecoxib, mechanism, fluconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Plasma exposure (AUC) to valdecoxib was increased 62% when coadministered with fluconazole and 38% when coadministered with ketoconazole.

Output: <valdecoxib, mechanism, fluconazole>, <valdecoxib, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of valdecoxib (40 mg BID (day 1) and 40 mg QD (days 2-7)) with glyburide (10 mg glyburide BID) resulted in 21% increase in glyburide AUC0-12 and a 16% increase in glyburide Cmax leading to a 16% decrease in glucose AUC0-24.

Output: <valdecoxib, mechanism, glyburide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because changes in glucose concentrations with valdecoxib coadministration were within the normal variability and individual glucose concentrations were above or near 70 mg/dL, dose adjustment for glyburide (5 mg QD and 10 mg BID) with valdecoxib coadministration (up to 40 mg QD) is not indicated.

Output: <glyburide, advise, valdecoxib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration with valdecoxib increased exposure of omeprazole (AUC) by 46%.

Output: <valdecoxib, mechanism, omeprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of valdecoxib and Ortho-Novum 1/35  increased the exposure of norethindrone and ethinyl estradiol by 20% and 34%, respectively.

Output: <valdecoxib, mechanism, Ortho-Novum>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: These increased exposures of norethindrone and ethinyl estradiol should be taken into consideration when selecting an oral contraceptive for women taking valdecoxib.

Output: <contraceptive, advise, valdecoxib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Plasma exposure of diazepam (10 mg BID) was increased by 28% following administration of valdecoxib (40 mg BID) for 12 days, while plasma exposure of valdecoxib (40 mg BID) was not substantially increased following administration of diazepam (10 mg BID) for 12 days.

Output: <diazepam, mechanism, valdecoxib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although the magnitude of changes in diazepam plasma exposure when coadministered with valdecoxib were not sufficient to warrant dosage adjustments, patients may experience enhanced sedative side effects caused by increased exposure of diazepam under this circumstance.

Output: <valdecoxib, effect, diazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Given the primary CNS effects of Clozapine, caution is advised in using it concomitantly with other CNS-active drugs or alcohol.

Output: <Clozapine, effect, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although it has not been established that there is an interaction between Clozapine and benzodiazepines or other psychotropics, caution is advised when clozapine is initiated in patients taking a benzodiazepine or any other psychotropic drug.

Output: <clozapine, advise, benzodiazepine>, <clozapine, advise, psychotropic drug>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Clozapine may potentiate the hypotensive effects of antihypertensive drugs and the anticholinergic effects of atropine-type drugs.

Output: <Clozapine, effect, antihypertensive drugs>, <Clozapine, effect, atropine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin, nicotine, and rifampin may decrease Clozapine plasma levels, resulting in a decrease in effectiveness of a previously effective Clozapine dose.

Output: <Phenytoin, mechanism, Clozapine>, <nicotine, mechanism, Clozapine>, <rifampin, mechanism, Clozapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine, caffeine, and erythromycin may increase plasma levels of Clozapine, potentially resulting in adverse effects.

Output: <Cimetidine, mechanism, Clozapine>, <caffeine, mechanism, Clozapine>, <erythromycin, mechanism, Clozapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although concomitant use of Clozapine and carbamazepine is not recommended, it should be noted that discontinuation of concomitant carbamazepine administration may result in an increase in Clozapine plasma levels.

Output: <Clozapine, advise, carbamazepine>, <carbamazepine, mechanism, Clozapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Paroxetine produced only minor changes in the levels of clozapine and its metabolites.

Output: <Paroxetine, mechanism, clozapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, other published reports describe modest elevations (less than two-fold) of clozapine and metabolite concentrations when clozapine was taken with paroxetine, fluoxetine, and sertraline.

Output: <clozapine, mechanism, paroxetine>, <clozapine, mechanism, fluoxetine>, <clozapine, mechanism, sertraline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, such combined treatment should be approached with caution and patients should be monitored closely when Clozapine is combined with these drugs, particularly with fluvoxamine.

Output: <Clozapine, advise, fluvoxamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, co-administration of clozapine with other drugs that are metabolized by this isozyme, including antidepressants, phenothiazines, carbamazepine, and Type 1C antiarrhythmics (e.g., propafenone, flecainide and encainide), or that inhibit this enzyme (e.g., quinidine), should be approached with caution.

Output: <clozapine, advise, antidepressants>, <clozapine, advise, phenothiazines>, <clozapine, advise, carbamazepine>, <clozapine, advise, Type 1C antiarrhythmics>, <clozapine, advise, propafenone>, <clozapine, advise, flecainide>, <clozapine, advise, encainide>, <clozapine, advise, quinidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Some quinolones, including ciprofloxacin, have also been shown to interfere with the metabolism of caffeine.

Output: <quinolones, mechanism, caffeine>, <ciprofloxacin, mechanism, caffeine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Some quinolones, including ciprofloxacin, have been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Output: <quinolones, effect, cyclosporine>, <ciprofloxacin, effect, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Glyburide: The concomitant administration of ciprofloxacin with the sulfonylurea glyburide has, on rare occasions, resulted in severe hypoglycemia.

Output: <ciprofloxacin, effect, sulfonylurea>, <ciprofloxacin, effect, glyburide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methotrexate Renal tubular transport of methotrexate may be inhibited by concomitant administration of ciprofloxacin, potentially leading to increased plasma levels of methotrexate.

Output: <methotrexate, mechanism, ciprofloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, patients under methotrexate therapy should be carefully monitored when concomitant ciprofloxacin therapy is indicated.

Output: <methotrexate, advise, ciprofloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Multivalent Cation-Containing Products: Concurrent administration of a quinolone, including ciprofloxacin, with multivalent cation-containing products such as magnesium or aluminum antacids, sucralfate, VIDEX chewable/buffered tablets or pediatric powder, or products containing calcium, iron, or zinc may substantially decrease the absorption of ciprofloxacin, resulting in serum and urine levels considerably lower than desired.

Output: <quinolone, mechanism, magnesium>, <quinolone, mechanism, aluminum>, <quinolone, mechanism, antacids>, <quinolone, mechanism, sucralfate>, <quinolone, mechanism, VIDEX>, <quinolone, mechanism, calcium>, <quinolone, mechanism, iron>, <quinolone, mechanism, zinc>, <ciprofloxacin, mechanism, magnesium>, <ciprofloxacin, mechanism, aluminum>, <ciprofloxacin, mechanism, antacids>, <ciprofloxacin, mechanism, sucralfate>, <ciprofloxacin, mechanism, VIDEX>, <ciprofloxacin, mechanism, calcium>, <ciprofloxacin, mechanism, iron>, <ciprofloxacin, mechanism, zinc>, <ciprofloxacin, mechanism, ciprofloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This time window is different than for other oral formulations of ciprofloxacin, which are usually administered 2 hours before or 6 hours after antacids.

Output: <ciprofloxacin, advise, antacids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin: Altered serum levels of phenytoin (increased and decreased) have been reported in patients receiving concomitant ciprofloxacin.

Output: <phenytoin, mechanism, ciprofloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid: Probenecid interferes with renal tubular secretion of ciprofloxacin and produces an increase in the level of ciprofloxacin in serum.

Output: <Probenecid, mechanism, ciprofloxacin>, <Probenecid, mechanism, ciprofloxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Theophylline: As with some other quinolones, concurrent administration of ciprofloxacin with theophylline may lead to elevated serum concentrations of theophylline and prolongation of its elimination half-life.

Output: <quinolones, mechanism, theophylline>, <ciprofloxacin, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin: Quinolones have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives.

Output: <Quinolones, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Bismuth: Bismuth subsalicylate, given concomitantly with enoxacin or 60 minutes following enoxacin administration, decreased enoxacin bioavailability by approximately 25%.

Output: <Bismuth subsalicylate, mechanism, enoxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus, concomitant administration of enoxacin and bismuth subsalicylate should be avoided.

Output: <enoxacin, advise, bismuth subsalicylate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caffeine: Enoxacin is a potent inhibitor of the cytochrome P-450 isozymes responsible for the metabolism of methylxanthines.

Output: <Enoxacin, mechanism, methylxanthines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a multiple-dose study, enoxacin caused a dose-related increase in the mean elimination half-life of caffeine, thereby decreasing the clearance of caffeine by up to 80% and leading to a five-fold increase in the AUC and the half-life of caffeine.

Output: <enoxacin, mechanism, caffeine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Trough plasma enoxacin levels were also 20% higher when caffeine and enoxacin were administered concomitantly.

Output: <caffeine, mechanism, enoxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caffeine-related adverse effects have occurred in patients consuming caffeine while on therapy with enoxacin.

Output: <caffeine, effect, enoxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclosporine: Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with other members of the quinolone class.

Output: <cyclosporine, mechanism, quinolone class>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digoxin: Enoxacin may raise serum digoxin levels in some individuals.

Output: <Enoxacin, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If signs and symptoms suggestive of digoxin toxicity occur when enoxacin and digoxin are given concomitantly, physicians are advised to obtain serum digoxin levels and adjust digoxin doses appropriately.

Output: <enoxacin, effect, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Non-steroidal anti-inflammatory agents: Seizures have been reported in patients taking enoxacin concomitantly with the nonsteroidal anti-inflammatory drug fenbufen.

Output: <enoxacin, effect, fenbufen>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: or with multivitamins containing zinc may substantially interfere with drug absorption and result in insufficient plasma and tissue quinolone concentrations.

Output: <zinc, mechanism, quinolone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids containing aluminum hydroxide and magnesium hydroxide reduce the oral absorption of enoxacin by 75%.

Output: <aluminum hydroxide, mechanism, enoxacin>, <magnesium hydroxide, mechanism, enoxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The oral bioavailability of enoxacin is reduced by 60% with coadministration of ranitidine.

Output: <enoxacin, mechanism, ranitidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Theophylline: Enoxacin is a potent inhibitor of the cytochrome P-450 isozymes responsible for the metabolism of methylxanthines.

Output: <Enoxacin, mechanism, methylxanthines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Enoxacin interferes with the metabolism of theophylline resulting in a 42% to 74% dose-related decrease in theophylline clearance and a subsequent 260% to 350% increase in serum theophylline levels.

Output: <Enoxacin, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Theophylline-related adverse effects have occurred in patients when theophylline and enoxacin were coadministered.

Output: <theophylline, effect, enoxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin: Quinolones, including enoxacin, decrease the clearance of R-warfarin, the less active isomer of racemic warfarin.

Output: <Quinolones, mechanism, R-warfarin>, <enoxacin, mechanism, R-warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nevertheless, the prothrombin time or other suitable coagulation test should be monitored when warfarin or its derivatives and enoxacin are given concomitantly.

Output: <warfarin, advise, enoxacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rifampin: Coadministration of rifampin and MEPRON Suspension results in a significant decrease in average steady- state plasma atovaquone concentrations.

Output: <rifampin, mechanism, MEPRON>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Alternatives to rifampin should be considered during the course of PCP treatment with MEPRON.

Output: <rifampin, advise, MEPRON>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Products containing calcium and other multivalent cations (such as aluminum, magnesium, iron) are likely to interfere with absorption of Ibandronate.

Output: <calcium, mechanism, Ibandronate>, <aluminum, mechanism, Ibandronate>, <magnesium, mechanism, Ibandronate>, <iron, mechanism, Ibandronate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ibandronate should be taken at least 60 minutes before any oral medications containing multivalent cations (including antacids, supplements or vitamins).

Output: <Ibandronate, advise, antacids>, <Ibandronate, advise, vitamins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, since aspirin, NSAIDs, and bisphosphonates are all associated with gastrointestinal irritation, caution should be exercised in the concomitant use of aspirin or NSAIDs with Ibandronate.

Output: <aspirin, advise, Ibandronate>, <NSAIDs, advise, Ibandronate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Total body clearance of Simulect was reduced by an average 22% and 51% when azathioprine and mycophenolate mofetil, respectively, were added to a regimen consisting of cyclosporine, USP (MODIFIED) and corticosteroids.

Output: <Simulect, mechanism, azathioprine>, <Simulect, mechanism, mycophenolate mofetil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The benzodiazepines, including alprazolam, produce additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol, and other drugs which themselves produce CNS depression.

Output: <benzodiazepines, effect, psychotropic medications>, <benzodiazepines, effect, anticonvulsants>, <benzodiazepines, effect, antihistaminics>, <benzodiazepines, effect, ethanol>, <alprazolam, effect, psychotropic medications>, <alprazolam, effect, anticonvulsants>, <alprazolam, effect, antihistaminics>, <alprazolam, effect, ethanol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The steady state plasma concentrations of imipramine and desipramine have been reported to be increased an average of 31% and 20%, respectively, by the concomitant administration of alprazolam tablets in doses up to 4 mg/day.

Output: <imipramine, mechanism, alprazolam>, <desipramine, mechanism, alprazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs Demonstrated to be CYP 3A Inhibitors of Possible Clinical Significance on the Basis of Clinical Studies Involving Alprazolam (caution is recommended during coadministration with alprazolam): Coadministration of fluoxetine with alprazolam increased the maximum plasma concentration of alprazolam by 46%, decreased clearance by 21%, increased half-life by 17%, and decreased measured psychomotor performance.

Output: <fluoxetine, mechanism, alprazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of propoxyphene decreased the maximum plasma concentration of alprazolam by 6%, decreased clearance by 38%, and increased half-life by 58%.

Output: <propoxyphene, mechanism, alprazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of oral contraceptives increased the maximum plasma concentration of alprazolam by 18%, decreased clearance by 22%, and increased half-life by 29%.

Output: <contraceptives, mechanism, alprazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs and other substances demonstrated to be CYP 3A inhibitors on the basis of clinical studies involving benzodiazepines metabolized similarly to alprazolam or on the basis of in vitro studies with alprazolam or other benzodiazepines (caution is recommended during coadministration with alprazolam): Available data from clinical studies of benzodiazepines other than alprazolam suggest a possible drug interaction with alprazolam for the following: diltiazem, isoniazid, macrolide antibiotics such as erythromycin and clarithromycin, and grapefruit juice.

Output: <alprazolam, int, diltiazem>, <alprazolam, int, isoniazid>, <alprazolam, int, macrolide antibiotics>, <alprazolam, int, erythromycin>, <alprazolam, int, clarithromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Data from in vitro studies of alprazolam suggest a possible drug interaction with alprazolam for the following: sertraline and paroxetine.

Output: <alprazolam, int, sertraline>, <alprazolam, int, paroxetine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Data from in vitro studies of benzodiazepines other than alprazolam suggest a possible drug interaction for the following: ergotamine, cyclosporine, amiodarone, nicardipine, and nifedipine.

Output: <benzodiazepines, int, ergotamine>, <benzodiazepines, int, cyclosporine>, <benzodiazepines, int, amiodarone>, <benzodiazepines, int, nicardipine>, <benzodiazepines, int, nifedipine>, <alprazolam, int, ergotamine>, <alprazolam, int, cyclosporine>, <alprazolam, int, amiodarone>, <alprazolam, int, nicardipine>, <alprazolam, int, nifedipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Interactions with Other CNS Agents: Concurrent use of Levo-Dromoran with all central nervous system depressants (eg, alcohol, sedatives, hypnotics, other opioids, general anesthetics, barbiturates, tricyclic antidepressants, phenothiazines, tranquilizers, skeletal muscle relaxants and antihistamines) may result in additive central nervous system depressant effects.

Output: <Levo-Dromoran, effect, central nervous system depressants>, <Levo-Dromoran, effect, alcohol>, <Levo-Dromoran, effect, sedatives>, <Levo-Dromoran, effect, hypnotics>, <Levo-Dromoran, effect, opioids>, <Levo-Dromoran, effect, anesthetics>, <Levo-Dromoran, effect, barbiturates>, <Levo-Dromoran, effect, tricyclic antidepressants>, <Levo-Dromoran, effect, phenothiazines>, <Levo-Dromoran, effect, tranquilizers>, <Levo-Dromoran, effect, skeletal muscle relaxants>, <Levo-Dromoran, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although no interaction between MAO inhibitors and Levo-Dromoran has been observed, it is not recommended for use with MAO inhibitors.

Output: <Levo-Dromoran, advise, MAO inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Interactions with Mixed Agonist/Antagonist Opioid Analgesics: Agonist/antagonist analgesics (eg, pentazocine, nalbuphine, butorphanol, dezocine and buprenorphine) should NOT be administered to a patient who has received or is receiving a course of therapy with a pure agonist opioid analgesic such as Levo-Dromoran.

Output: <Agonist/antagonist analgesics, advise, Levo-Dromoran>, <pentazocine, advise, Levo-Dromoran>, <nalbuphine, advise, Levo-Dromoran>, <butorphanol, advise, Levo-Dromoran>, <dezocine, advise, Levo-Dromoran>, <buprenorphine, advise, Levo-Dromoran>, <pure agonist opioid analgesic, advise, Levo-Dromoran>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Amitriptyline: Concurrent administration of 25 mg or 100 mg cinacalcet with 50 mg amitriptyline increased amitriptyline exposure and nortriptyline (active metabolite) exposure by approximately 20% in CYP2D6 extensive metabolizers.

Output: <cinacalcet, mechanism, amitriptyline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration of ketoconazole, a strong inhibitor of CYP3A4, increased cinacalcet exposure following a single 90 mg dose of Sensipar by 2.3 fold.

Output: <ketoconazole, mechanism, cinacalcet>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dose adjustment of Sensipar may be required and PTH and serum calcium concentrations should be closely monitored if a patient initiates or discontinues therapy with a strong CYP3A4 inhibitor (e.g., ketoconazole, erythromycin, itraconazole;

Output: <Sensipar, advise, ketoconazole>, <Sensipar, advise, erythromycin>, <Sensipar, advise, itraconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-treatment with the potent CYP3A4 inhibitor ketoconazole increases erlotinib AUC by 2/3.

Output: <ketoconazole, mechanism, erlotinib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be used when administering or taking TARCEVA with ketoconazole and other strong CYP3A4 inhibitors such as, but not limited to, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin (TAO), and voriconazole .

Output: <TARCEVA, advise, ketoconazole>, <TARCEVA, advise, atazanavir>, <TARCEVA, advise, clarithromycin>, <TARCEVA, advise, indinavir>, <TARCEVA, advise, itraconazole>, <TARCEVA, advise, nefazodone>, <TARCEVA, advise, nelfinavir>, <TARCEVA, advise, ritonavir>, <TARCEVA, advise, saquinavir>, <TARCEVA, advise, telithromycin>, <TARCEVA, advise, troleandomycin>, <TARCEVA, advise, TAO>, <TARCEVA, advise, voriconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pre-treatment with the CYP3A4 inducer rifampicin decreased erlotinib AUC by about 2/3.

Output: <rifampicin, mechanism, erlotinib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If the TARCEVA dose is adjusted upward, the dose will need to be reduced upon discontinuation of rifampicin or other inducers.

Output: <TARCEVA, advise, rifampicin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other depressasnts such as alcohol, barbiturates, and MAOIs may enhance CNS depression when administered with ethchlorvynol.

Output: <alcohol, effect, ethchlorvynol>, <barbiturates, effect, ethchlorvynol>, <MAOIs, effect, ethchlorvynol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In the first study, concomitant administration of 0.2 mg cerivastatin sodium and 12 g cholestyramine resulted in decreases of more than 22% for AUC and 40% for Cmax when compared to dosing cerivastatin sodium alone.

Output: <cerivastatin sodium, mechanism, cholestyramine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, in the second study, administration of 12 g cholestyramine 1 hour before the evening meal and 0.3 mg cerivastatin sodium approximately 4 hours after the same evening meal resulted in a decrease in the cerivastatin AUC of less than 8%, and a decrease in Cmax of about 30% when compared to dosing cerivastatin sodium alone.

Output: <cholestyramine, mechanism, cerivastatin sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ERYTHROMYCIN: In hypercholesterolemic patients, steady-state cerivastatin AUC and Cmax increased approximately 50% and 24% respectively after 10 days with co-administration of erythromycin, a known inhibitor of cytochrome P450 3A4.

Output: <cerivastatin, mechanism, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Allopurinol: The AUC of didanosine was increased about 4-fold when allopurinol at 300 mg/day was coadministered with a single 200-mg dose of VIDEX to two patients with renal impairment (CLcr=15 and 18 mL/min).

Output: <allopurinol, mechanism, VIDEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacids: Concomitant administration of antacids containing magnesium or aluminum with VIDEX Chewable/Dispersible Buffered Tablets or Pediatric Powder for Oral Solution may potentiate adverse events associated with the antacid components.

Output: <antacids, effect, VIDEX>, <magnesium, effect, VIDEX>, <aluminum, effect, VIDEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs Whose Absorption Can Be Affected by the Level of Acidity in the Stomach: Drugs such as ketoconazole and itraconazole should be administered at least 2 hours prior to dosing with VIDEX.

Output: <ketoconazole, advise, VIDEX>, <itraconazole, advise, VIDEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ganciclovir: Administration of VIDEX 2 hours prior to or concurrent with oral ganciclovir was associated with a 111 (114)% increase in the steady-state AUC of didanosine (n = 12).

Output: <VIDEX, mechanism, ganciclovir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A 21 (17)% decrease in the steady-state AUC of ganciclovir was observed when VIDEX was administered 2 hours prior to ganciclovir, but not when the two drugs were administered simultaneously (n = 12).

Output: <VIDEX, mechanism, ganciclovir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Quinolone Antibiotics: VIDEX should be administered at least 2 hours after or 6 hours before dosing with ciprofloxacin because plasma concentrations of ciprofloxacin are decreased when administered with antacids containing magnesium, calcium, or aluminum.

Output: <VIDEX, advise, ciprofloxacin>, <ciprofloxacin, mechanism, magnesium>, <ciprofloxacin, mechanism, calcium>, <ciprofloxacin, mechanism, aluminum>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In eight HIV-infected patients, the steady-state AUC of ciprofloxacin was decreased an average of 26% (95% CI = 14%, 37%) when ciprofloxacin was administered 2 hours prior to a marketed chewable/dispersible tablet formulation of VIDEX.

Output: <ciprofloxacin, mechanism, VIDEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The AUC of ciprofloxacin was decreased an average of 15-fold in 12 healthy subjects given ciprofloxacin and didanosine-placebo tablets concurrently.

Output: <ciprofloxacin, mechanism, didanosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a single subject given one dose of ciprofloxacin 2 hours after a dose of didanosine-placebo tablets, a greater than 50% reduction in the AUC of ciprofloxacin was observed.

Output: <ciprofloxacin, mechanism, didanosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Plasma concentrations of quinolone antibiotics are decreased when administered with antacids containing magnesium, calcium, or aluminum.

Output: <quinolone antibiotics, mechanism, magnesium>, <quinolone antibiotics, mechanism, calcium>, <quinolone antibiotics, mechanism, aluminum>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Interactions with Other Antiretroviral Drugs: Significant decreases in the AUC of delavirdine (20%) and indinavir (84%) occurred following simultaneous administration of these agents with VIDEX.

Output: <delavirdine, mechanism, VIDEX>, <indinavir, mechanism, VIDEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: To avoid this interaction, delavirdine or indinavir should be given 1 hour prior to dosing with VIDEX.

Output: <delavirdine, advise, VIDEX>, <indinavir, advise, VIDEX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.

Output: <SSRI, effect, TCA>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nevertheless, caution is indicated in the coadministration of TCAs with any of the SSRIs and also in switching from one class to the other.

Output: <TCAs, advise, SSRIs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hyperpyrexia has been reported when amitriptyline HCl is administered with anticholinergic agents or with neuroleptic drugs, particularly during hot weather.

Output: <amitriptyline HCl, effect, anticholinergic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Paralytic ileus may occur in patients taking tricyclic antidepressants in combination with anticholinergic-type drugs.

Output: <tricyclic antidepressants, effect, anticholinergic>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine is reported to reduce hepatic metabolism of certain tricyclic antidepressants, thereby delaying elimination and increasing steady-state concentrations of these drugs.

Output: <Cimetidine, mechanism, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Clinically significant effects have been reported with the tricyclic antidepressants when used concomitantly with cimetidine.

Output: <tricyclic antidepressants, effect, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Increases in plasma levels of tricyclic antidepressants, and in the frequency and severity of side effects, particularly anticholinergic, have been reported when cimetidine was added to the drug regimen.

Output: <tricyclic antidepressants, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Discontinuation of cimetidine in well-controlled patients receiving tricyclic antidepressants and cimetidine may decrease the plasma levels and efficacy of the antidepressants.

Output: <tricyclic antidepressants, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Transient delirium has been reported in patients who were treated with one gram of ethchlorvynol and 75 - 150 mg of amitriptyline HCl.

Output: <ethchlorvynol, effect, amitriptyline HCl>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with Tiazac.

Output: <beta-blockers, effect, Tiazac>, <digitalis, effect, Tiazac>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of diltiazem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%.

Output: <diltiazem hydrochloride, mechanism, propranolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In vitro, propranolol appears to be displaced from its binding sites by diltiazem.

Output: <propranolol, mechanism, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and AUC (53%) after a 1-week course of cimetidine 1200 mg/day and a single dose of diltiazem 60mg.

Output: <cimetidine, mechanism, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The effect may be mediated by cimetidines known inhibition of hepatic cytochrome P-450, the enzyme system responsible for the first-pass metabolism of diltiazem.

Output: <cimetidine, mechanism, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients currently receiving diltiazem therapy should be carefully monitored for a change in pharmacological effect when initiating and discontinuing therapy with cimetidine.

Output: <diltiazem, advise, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%.

Output: <diltiazem hydrochloride, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since there have been conflicting results regarding the effect of digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing diltiazem hydrochloride therapy to avoid possible over- or under-digitalization.

Output: <digoxin, advise, diltiazem hydrochloride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The depression of cardiac contractility, conductivity, and automaticity as well as the vascular dilation associated with anesthetics may be potentiated by calcium channel blockers.

Output: <anesthetics, effect, calcium channel blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When used concomitantly, anesthetics and calcium channel blockers should be titrated carefully.

Output: <anesthetics, advise, calcium channel blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A pharmacokinetic interaction between diltiazem and cyclosporine has been observed during studies involving renal and cardiac transplant patients.

Output: <diltiazem, int, cyclosporine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of diltiazem.

Output: <cyclosporine, mechanism, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when diltiazem therapy is initiated, adjusted, or discontinued.

Output: <cyclosporine, advise, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine (40% to 72% increase), resulting in toxicity in some cases.

Output: <diltiazem, mechanism, carbamazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3-4 fold and the Cmax by 2-fold, compared to placebo.

Output: <diltiazem, mechanism, midazolam>, <diltiazem, mechanism, triazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The elimination half life of midazolam and triazolam also increased (1.5-2.5 fold) during coadministration with diltiazem.

Output: <midazolam, mechanism, diltiazem>, <triazolam, mechanism, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sodation)of both midazolam and triazolam.

Output: <diltiazem, effect, midazolam>, <diltiazem, effect, triazolam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a ten-subject study, coadministration of diltiazem (120 mg bid) with lovastatin resulted in a 3-4 times increase in mean lovastatin AUC and Cmax vs. lovastatin alone;

Output: <diltiazem, mechanism, lovastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels.

Output: <rifampin, mechanism, diltiazem>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration of diltiazem with rifampin or any known CYP3A4 inducer should be avoided when possible, and alternative therapy considered.

Output: <diltiazem, advise, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Combinations of these drugs have not been studied and coadministration of CRIXIVAN and atazanavir is not recommended.

Output: <CRIXIVAN, advise, atazanavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dose reduction of CRIXIVAN to 600 mg every 8 hours should be considered when taking delavirdine 400 mg three times a day.

Output: <CRIXIVAN, advise, delavirdine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Indinavir and didanosine formulations containing buffer should be administered at least one hour apart on an empty stomach.

Output: <Indinavir, advise, didanosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Increasing the indinavir dose to 1000 mg every 8 hours does not compensate for the increased indinavir metabolism due to efavirenz.

Output: <indinavir, mechanism, efavirenz>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Indinavir concentrations may be decreased in the presence of nevirapine.

Output: <Indinavir, mechanism, nevirapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Preliminary clinical data suggest that the incidence of nephrolithiasis is higher in patients receiving indinavir in combination with ritonavir than those receiving CRIXIVAN 800 mg q8h.

Output: <indinavir, effect, ritonavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution is warranted and therapeutic concentration monitoring is recommended for antiarrhythmics when coadministered with CRIXIVAN.

Output: <antiarrhythmics, advise, CRIXIVAN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: CRIXIVAN may not be effective due to decreased indinavir concentrations in patients taking these agents concomitantly.

Output: <CRIXIVAN, effect, indinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Use lowest possible dose of atorvastatin with careful monitoring, or consider HMG-CoA reductase inhibitors that are not primarily metabolized by CYP3A4, such as pravastatin, fluvastatin, or rosuvastatin in combination with CRIXIVAN.

Output: <atorvastatin, advise, CRIXIVAN>, <HMG-CoA reductase inhibitors, advise, CRIXIVAN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dose reduction of CRIXIVAN to 600 mg every 8 hours is recommended when administering itraconazole concurrently.

Output: <CRIXIVAN, advise, itraconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dose reduction of rifabutin to half the standard dose and a dose increase of CRIXIVAN to 1000 mg (three 333-mg capsules) every 8 hours are recommended when rifabutin and CRIXIVAN are coadministered.

Output: <rifabutin, advise, CRIXIVAN>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sildenafil dose should not exceed a maximum of 25 mg in a 48- hour period in patients receiving concomitant indinavir therapy.

Output: <Sildenafil, advise, indinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tadalafil dose should not exceed a maximum of 10 mg in a 72- hour period in patients receiving concomitant indinavir therapy.

Output: <Tadalafil, advise, indinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Vardenafil dose should not exceed a maximum of 2.5 mg in a 24-hour period in patients receiving concomitant indinavir therapy.

Output: <Vardenafil, advise, indinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digoxin: Coadministration of digoxin, a P-glycoprotein substrate, with oral conivaptan resulted in a reduction in clearance and an increase in digoxin Cmax and AUC values.

Output: <digoxin, mechanism, conivaptan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, if digoxin is administered with VAPRISOL, the clinician should be alert to the possibility of increases in digoxin levels.

Output: <digoxin, mechanism, VAPRISOL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There have been isolated reports of patients experiencing increases in their prothrombin times when etidronate was added to warfarin therapy.

Output: <etidronate, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Wait 5 weeks after stopping escitalopram before starting a non-selective MAO inhibitor.

Output: <escitalopram, advise, non-selective MAO inhibitor>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Wait 2 weeks after stopping an MAO inhibitor before starting escitalopram.

Output: <MAO inhibitor, advise, escitalopram>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity.

Output: <Erythromycin, effect, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In case of theophylline toxicity and/or elevated serum theophylline levels, the dose of theophylline should be reduced while the patient is receiving concomitant erythromycin therapy.

Output: <theophylline, advise, erythromycin>