Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dexamethasone: Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in eight neurocysticercosis patients.

Output: <dexamethasone, mechanism, albendazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Praziquantel: In the fed state, praziquantel (40 mg/kg) increased mean maximum plasma concentration and area under the curve of albendazole sulfoxide by about 50% in healthy subjects (n=10) compared with a separate group of subjects (n=6) given albendazole alone.

Output: <praziquantel, mechanism, albendazole sulfoxide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine: Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n=7) compared with albendazole (20 mg/kg/day) alone (n=12).

Output: <Albendazole sulfoxide, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators.

Output: <isosorbide dinitrate, effect, vasodilators>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Inhibitors of CYP1A2: Concomitant use of duloxetine with fluvoxamine, an inhibitor of CYP1A2, results in approximately a 6-fold increase in AUC and about a 2.5-fold increase in Cmax of duloxetine.

Output: <duloxetine, mechanism, fluvoxamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Paroxetine (20 mg QD) increased the concentration of duloxetine (40 mg QD) by about 60%, and greater degrees of inhibition are expected with higher doses of paroxetine.

Output: <Paroxetine, mechanism, duloxetine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When duloxetine was administered (at a dose of 60 mg BID) in conjunction with a single 50-mg dose of desipramine, a CYP2D6 substrate, the AUC of desipramine increased 3-fold.

Output: <duloxetine, mechanism, desipramine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, co-administration of Duloxetine with other drugs that are extensively metabolized by this isozyme and which have a narrow therapeutic index, including certain antidepressants (tricyclic antidepressants [TCAs], such as nortriptyline, amitriptyline, and imipramine), phenothiazines and Type 1C antiarrhythmics (e.g., propafenone, flecainide), should be approached with caution.

Output: <Duloxetine, advise, antidepressants>, <Duloxetine, advise, tricyclic antidepressants>, <Duloxetine, advise, TCAs>, <Duloxetine, advise, nortriptyline>, <Duloxetine, advise, amitriptyline>, <Duloxetine, advise, imipramine>, <Duloxetine, advise, phenothiazines>, <Duloxetine, advise, Type 1C antiarrhythmics>, <Duloxetine, advise, propafenone>, <Duloxetine, advise, flecainide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Plasma TCA concentrations may need to be monitored and the dose of the TCA may need to be reduced if a TCA is co-administered with Duloxetine.

Output: <TCA, advise, Duloxetine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because of the risk of serious ventricular arrhythmias and sudden death potentially associated with elevated plasma levels of thioridazine, Duloxetine and thioridazine should not be co-administered.

Output: <Duloxetine, advise, thioridazine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Naproxen: Coadministration (N=18) of naproxen sodium capsules (250 mg) with Neurontin (125 mg) appears to increase the amount of gabapentin absorbed by 12% to 15%.

Output: <naproxen sodium, mechanism, Neurontin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hydrocodone increases gabapentin AUC values by 14%.

Output: <Hydrocodone, mechanism, gabapentin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Morphine: A literature article reported that when a 60-mg controlled-release morphine capsule was administered 2 hours prior to a 600-mg Neurontin  capsule (N=12), mean gabapentin AUC increased by 44% compared to gabapentin administered without morphine.

Output: <morphine, mechanism, Neurontin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine: In the presence of cimetidine at 300 mg QID (N=12) the mean apparent oral clearance of gabapentin fell by 14% and creatinine clearance fell by 10%.

Output: <cimetidine, mechanism, gabapentin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus cimetidine appeared to alter the renal excretion of both gabapentin and creatinine, an endogenous marker of renal function.

Output: <cimetidine, mechanism, gabapentin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This small decrease in excretion of gabapentin by cimetidine is not expected to be of clinical importance.

Output: <gabapentin, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The Cmax of norethindrone was 13% higher when it was coadministered with gabapentin;

Output: <norethindrone, mechanism, gabapentin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacid (Maalox ): Maalox reduced the bioavailability of gabapentin (N=16) by about 20%.

Output: <Maalox, mechanism, gabapentin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This decrease in bioavailability was about 5% when gabapentin was administered 2 hours after Maalox.

Output: <gabapentin, mechanism, Maalox>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended that gabapentin be taken at least 2 hours following Maalox administration.

Output: <gabapentin, advise, Maalox>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is, however, possible that concomitant use of other known photosensitizing agents such as griseofulvin, thiazide diuretics, sulfonylureas, phenothiazines, sulfonamides and tetracyclines might increase the photosensitivity reaction of actinic keratoses treated with the LEVULAN KERASTICK for Topical Solution.

Output: <photosensitizing agents, effect, LEVULAN KERASTICK>, <griseofulvin, effect, LEVULAN KERASTICK>, <thiazide diuretics, effect, LEVULAN KERASTICK>, <sulfonylureas, effect, LEVULAN KERASTICK>, <phenothiazines, effect, LEVULAN KERASTICK>, <sulfonamides, effect, LEVULAN KERASTICK>, <tetracyclines, effect, LEVULAN KERASTICK>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Zalcitabine also has no significant effect on the intracellular phosphorylation of ZDV, as shown in vitro in peripheral blood mononuclear cells or in two other cell lines (U937 and Molt-4).

Output: <Zalcitabine, effect, ZDV>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lamivudine: In vitro studies in peripheral blood mononuclear cells, U937 and Molt-4 cells revealed that lamivudine significantly inhibited zalcitabine phosphorylation in a dose dependent manner.

Output: <lamivudine, effect, zalcitabine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Zalcitabine inhibited lamivudine phosphorylation at high concentration ratios (10 and 100);

Output: <Zalcitabine, effect, lamivudine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: These in vitro studies suggest that concomitant administration of zalcitabine and lamivudine in humans may result in sub-therapeutic concentrations of active phosphorylated zalcitabine, which may lead to a decreased antiretroviral effect of zalcitabine.

Output: <zalcitabine, effect, lamivudine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of zalcitabine and lamivudine is not recommended.

Output: <zalcitabine, advise, lamivudine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of HIVID with didanosine is not recommended.

Output: <HIVID, advise, didanosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Death due to fulminant pancreatitis possibly related to intravenous pentamidine and HIVID has been reported.

Output: <pentamidine, effect, HIVID>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If intravenous pentamidine is required to treat Pneumocystis carinii pneumonia, treatment with HIVID should be interrupted.

Output: <pentamidine, advise, HIVID>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Amphotericin, Foscarnet, and Aminoglycosides: Drugs such as amphotericin, foscarnet, and aminoglycosides may increase the risk of developing peripheral neuropathy or other HIVID-associated adverse events by interfering with the renal clearance of zalcitabine (thereby raising systemic exposure).

Output: <amphotericin, effect, HIVID>, <amphotericin, mechanism, zalcitabine>, <foscarnet, effect, HIVID>, <foscarnet, mechanism, zalcitabine>, <aminoglycosides, effect, HIVID>, <aminoglycosides, mechanism, zalcitabine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid or Cimetidine: Concomitant administration of probenecid or cimetidine decreases the elimination of zalcitabine, most likely by inhibition of renal tubular secretion of zalcitabine.

Output: <probenecid, mechanism, zalcitabine>, <cimetidine, mechanism, zalcitabine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The clinical significance of this reduction is not known, hence zalcitabine is not recommended to be ingested simultaneously with magnesium/aluminum-containing antacids.

Output: <zalcitabine, advise, magnesium>, <zalcitabine, advise, aluminum>, <zalcitabine, advise, antacids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Metoclopramide: Bioavailability is mildly reduced (approximately 10%) when zalcitabine and metoclopramide are coadministered.

Output: <zalcitabine, mechanism, metoclopramide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Doxorubicin: Doxorubicin caused a decrease in zalcitabine phosphorylation ( 50% inhibition of total phosphate formation) in U937/Molt 4 cells.

Output: <Doxorubicin, effect, zalcitabine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Acidifying agents: Gastrointestinal acidifying agents (guanethidine, reserpine, glutamic acid HCl, ascorbic acid, fruit juices, etc.) lower absorption of amphetamines.

Output: <Gastrointestinal acidifying agents, mechanism, amphetamines>, <guanethidine, mechanism, amphetamines>, <reserpine, mechanism, amphetamines>, <glutamic acid HCl, mechanism, amphetamines>, <ascorbic acid, mechanism, amphetamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Urinary acidifying agents (ammonium chloride, sodium acid phosphate, etc.) increase the concentration of the ionized species of the amphetamine molecule, thereby increasing urinary excretion.

Output: <Urinary acidifying agents, mechanism, amphetamine>, <ammonium chloride, mechanism, amphetamine>, <sodium acid phosphate, mechanism, amphetamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Adrenergic blockers: Adrenergic blockers are inhibited by amphetamines.

Output: <Adrenergic blockers, effect, amphetamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Alkalinizing agents: Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines.

Output: <sodium bicarbonate, mechanism, amphetamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion.

Output: <acetazolamide, mechanism, amphetamine>, <thiazides, mechanism, amphetamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antidepressants, tricyclic: Amphetamines may enhance the activity of tricyclic or sympathomimetic agents;

Output: <Amphetamines, effect, tricyclic>, <Amphetamines, effect, sympathomimetic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain;

Output: <d-amphetamine, mechanism, desipramine>, <d-amphetamine, mechanism, protriptyline>, <d-amphetamine, mechanism, tricyclics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: MAO inhibitors: MAOI antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism.

Output: <MAOI antidepressants, mechanism, amphetamine>, <furazolidone, mechanism, amphetamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antihistamines: Amphetamines may counteract the sedative effect of antihistamines.

Output: <Amphetamines, effect, antihistamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antihypertensives: Amphetamines may antagonize the hypotensive effects of antihypertensives.

Output: <Amphetamines, effect, antihypertensives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Chlorpromazine: Chlorpromazine blocks dopamine and norepinephrine reuptake, thus inhibiting the central stimulant effects of amphetamines, and can be used to treat amphetamine poisoning.

Output: <Chlorpromazine, effect, amphetamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ethosuximide: Amphetamines may delay intestinal absorption of ethosuximide.

Output: <Amphetamines, mechanism, ethosuximide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Haloperidol: Haloperidol blocks dopamine and norepinephrine reuptake, thus inhibiting the central stimulant effects of amphetamines.

Output: <Haloperidol, effect, amphetamines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium carbonate: The stimulatory effects of amphetamines may be inhibited by lithium carbonate.

Output: <amphetamines, effect, lithium carbonate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Meperidine: Amphetamines potentiate the analgesic effect of meperidine.

Output: <Amphetamines, effect, meperidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methenamine therapy: Urinary excretion of amphetamines is increased, and efficacy is reduced, by acidifying agents used in methenamine therapy.

Output: <amphetamines, mechanism, acidifying agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Norepinephrine: Amphetamines enhance the adrenergic effect of norepinephrine.

Output: <Amphetamines, effect, norepinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenobarbital: Amphetamines may delay intestinal absorption of phenobarbital;

Output: <Amphetamines, mechanism, phenobarbital>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin: Amphetamines may delay intestinal absorption of phenytoin;

Output: <Amphetamines, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Propoxyphene: In cases of propoxyphene overdosage, amphetamine CNS stimulation is potentiated and fatal convulsions can occur.

Output: <propoxyphene, effect, amphetamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Veratrum alkaloids: Amphetamines inhibit the hypotensive effect of veratrum alkaloids.

Output: <Amphetamines, effect, veratrum alkaloids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of loratadine relative to that observed with erythromycin alone.

Output: <erythromycin, mechanism, loratadine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tablet If a patient receiving clonidine hydrochloride is also taking tricyclic antidepressants, the effect of clonidine may be reduced, thus necessitating an increase in dosage.

Output: <clonidine hydrochloride, effect, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Clonidine hydrochloride may enhance the CNS-depressive effects of alcohol, barbiturates or other sedatives.

Output: <Clonidine hydrochloride, effect, alcohol>, <Clonidine hydrochloride, effect, barbiturates>, <Clonidine hydrochloride, effect, sedatives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats Epidural Injection Clonidine may potentiate the CNS-depressive effect of alcohol, barbiturates or other sedating drugs.

Output: <Amitriptyline, effect, clonidine>, <Clonidine, effect, alcohol>, <Clonidine, effect, barbiturates>, <Clonidine, effect, sedating drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Narcotic analgesics may potentiate the hypotensive effects of clonidine.

Output: <Narcotic analgesics, effect, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tricyclic antidepressants may antagonize the hypotensive effects of clonidine.

Output: <Tricyclic antidepressants, effect, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta blockers may exacerbate the hypertensive response seen with clonidine withdrawl.

Output: <Beta blockers, effect, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Also, due to the potential for additive effects such as bradycardia and AV block, caution is warranted in patients receiving clonidine with agents known to affect sinus node function or AV nodal conduction (e.g., digitalis, calcium channel blockers, and beta-blockers.)

Output: <clonidine, advise, digitalis>, <clonidine, advise, calcium channel blockers>, <clonidine, advise, beta-blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There is one reported case of a patient with acute delirium associated with the simultaneous use of fluphenazine and oral clonidine.

Output: <fluphenazine, effect, clonidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Epidural clonidine may prolong the duration of pharmacologic effects of epidural local anesthetics, including both sensory and motor blockade.

Output: <clonidine, effect, anesthetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In addition, several AED s that are cytochrome P450 inducers can decrease plasma concentrations of oxcarbazepine and MHD.

Output: <AED, mechanism, oxcarbazepine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: 1- nc denotes a mean change of less than 10% 2- Pediatrics 3- Mean increase in adults at high Trileptal doses In vivo, the plasma levels of phenytoin increased by up to 40%, when Trileptal was given at doses above 1200 mg/day.

Output: <phenytoin, mechanism, Trileptal>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, when using doses of Trileptal greater than 1200 mg/day during adjunctive therapy, a decrease in the dose of phenytoin may be required.

Output: <Trileptal, advise, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The increase of phenobarbital level, however, is small (15%) when given with Trileptal.

Output: <phenobarbital, mechanism, Trileptal>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Hormonal contraceptives Co-administration of Trileptal with an oral contraceptive has been shown to influence the plasma concentrations of the two hormonal components, ethinylestradiol (EE) and levonorgestrel (LNG).

Output: <Trileptal, mechanism, contraceptive>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, concurrent use of Trileptal with hormonal contraceptives may render these contraceptives less effective.

Output: <Trileptal, effect, hormonal contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Calcium Antagonists: After repeated co-administration of Trileptal, the AUC of felodipine was lowered by 28% [90% CI: 20-33].

Output: <Trileptal, mechanism, felodipine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with dihydrotachysterol may cause hypercalcemia.

Output: <thiazide diuretics, effect, dihydrotachysterol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Lofexidine may enhance the CNS depressive effects of alcohol, barbiturates and other sedatives

Output: <Lofexidine, effect, alcohol>, <Lofexidine, effect, barbiturates>, <Lofexidine, effect, sedatives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Lofexidine may enhance the effects of anti-hypertensive drug therapy

Output: <Lofexidine, effect, anti-hypertensive drug>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: - Concomitant use of tricyclic antidepressants may reduce the efficacy of lofexidine.

Output: <tricyclic antidepressants, effect, lofexidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although the clinical significance is not known, it is not recommended that cefditoren pivoxil be taken concomitantly with antacids.

Output: <cefditoren pivoxil, advise, antacids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: H2-Receptor Antagonists: Co-administration of a single dose of intravenously administered famotidine (20 mg) reduced the oral absorption of a single 400 mg dose of cefditoren pivoxil administered following a meal, as evidenced by a 27% decrease in mean Cmax and a 22% decrease in mean AUC.

Output: <famotidine, mechanism, cefditoren pivoxil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid: As with other b-lactam antibiotics, co-administration of probenecid with cefditoren pivoxil resulted in an increase in the plasma exposure of cefditoren, with a 49% increase in mean Cmax, a 122% increase in mean AUC, and a 53% increase in half-life.

Output: <b-lactam antibiotics, mechanism, cefditoren pivoxil>, <probenecid, mechanism, cefditoren pivoxil>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When atropine and pralidoxime are used together, the signs of atropinization (flushing, mydriasis, tachycardia, dryness of the mouth and nose) may occur earlier than might be expected than when atropine is used alone because pralidoxime may potentiate the effect of atropine.

Output: <atropine, effect, pralidoxime>, <pralidoxime, effect, atropine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The following precautions should be kept in mind in the treatment of anticholinesterase poisoning although they do not bear directly on the use of atropine and pralidoxime.

Output: <atropine, advise, pralidoxime>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since barbiturates are potentiated by the anticholinesterases, they should be used cautiously in the treatment of convulsions.

Output: <barbiturates, advise, anticholinesterases>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ocupress should be used with caution in patients who are receiving a beta-adrenergic blocking agent orally because of the potential for additive effects on systemic beta-blockade.

Output: <Ocupress, advise, beta-adrenergic blocking agent>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may produce vertigo, syncope, or postural hypotension.

Output: <beta-blocker, advise, reserpine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although specific studies have not been performed, coadministration with drugs that are mainly metabolized by CYP3A4 (eg, calcium channel blockers, dapsone, disopyramide, quinine, amiodarone, quinidine, warfarin, tacrolimus, cyclosporine, ergot derivatives, pimozide, carbamazepine, fentanyl, alfentanyl, alprazolam, and triazolam) may have elevated plasma concentrations when coadministered with saquinavir;

Output: <calcium channel blockers, mechanism, saquinavir>, <dapsone, mechanism, saquinavir>, <disopyramide, mechanism, saquinavir>, <quinine, mechanism, saquinavir>, <amiodarone, mechanism, saquinavir>, <quinidine, mechanism, saquinavir>, <warfarin, mechanism, saquinavir>, <tacrolimus, mechanism, saquinavir>, <cyclosporine, mechanism, saquinavir>, <ergot derivatives, mechanism, saquinavir>, <pimozide, mechanism, saquinavir>, <carbamazepine, mechanism, saquinavir>, <fentanyl, mechanism, saquinavir>, <alfentanyl, mechanism, saquinavir>, <alprazolam, mechanism, saquinavir>, <triazolam, mechanism, saquinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Since INVIRASE is coadministered with ritonavir, the ritonavir label should be reviewed for additional drugs that should not be coadministered.

Output: <INVIRASE, advise, ritonavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Coadministration with compounds that are potent inducers of CYP3A4 (eg, phenobarbital, phenytoin, dexamethasone, carbamazepine) may result in decreased plasma levels of saquinavir.

Output: <phenobarbital, mechanism, saquinavir>, <phenytoin, mechanism, saquinavir>, <dexamethasone, mechanism, saquinavir>, <carbamazepine, mechanism, saquinavir>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In vitro mixing of an aminoglycoside with beta-lactamtype antibiotics (penicillins or cephalosporins) may result in a significant mutual inactivation.

Output: <aminoglycoside, effect, antibiotics>, <aminoglycoside, effect, penicillins>, <aminoglycoside, effect, cephalosporins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Even when an aminoglycoside and a penicillin-type drug are administered separately by different routes, a reduction in aminoglycoside serum half-life or serum levels has been reported in patients with impaired renal function and in some patients with normal renal function.

Output: <aminoglycoside, mechanism, penicillin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ethanol:Clinical evidence has shown that etretinate can be formed with concurrent ingestion of acitretin and ethanol.

Output: <acitretin, mechanism, ethanol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Glibenclamide: In a study of 7 healthy male volunteers, acitretin treatment potentiated the blood glucose lowering effect of glibenclamide (a sulfonylurea similar to chlorpropamide) in 3 of the 7 subjects.

Output: <acitretin, effect, glibenclamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, it has been established that acitretin interferes with the contraceptive effect of microdosed progestin minipill preparations.

Output: <acitretin, effect, progestin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Microdosed minipill progestin preparations are not recommended for use with Soriatane.

Output: <progestin, advise, Soriatane>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methotrexate: An increased risk of hepatitis has been reported to result from combined use of methotrexate and etretinate.

Output: <methotrexate, effect, etretinate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Consequently, the combination of methotrexate with acitretin is also contraindicated.

Output: <methotrexate, advise, acitretin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin: If acitretin is given concurrently with phenytoin, the protein binding of phenytoin may be reduced.

Output: <acitretin, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tetracyclines: Since both acitretin and tetracyclines can cause increased intracranial pressure, their combined use is contraindicated.

Output: <acitretin, effect, tetracyclines>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Vitamin A and oral retinoids: Concomitant administration of vitamin A and/or other oral retinoids with acitretin must be avoided because of the risk of hypervitaminosis A.

Output: <vitamin A, advise, acitretin>, <retinoids, advise, acitretin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Use of Cerubidine in a patient who has previously received doxorubicin increases the risk of cardiotoxicity.

Output: <Cerubidine, effect, doxorubicin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cerubidine should not be used in patients who have previously received the recommended maximum cumulative doses of doxorubicin or Cerubidine.

Output: <Cerubidine, advise, doxorubicin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cyclophosphamide used concurrently with Cerubidine may also result in increased cardiotoxicity.

Output: <Cyclophosphamide, effect, Cerubidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, the concomitant use of Argatroban and warfarin (5-7.5 mg initial oral dose followed by 2.5-6 mg/day orally for 6-10 days) results in prolongation of the prothrombin time (PT) and International Normalized Ratio (INR).

Output: <Argatroban, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Co-administration: Concomitant use of Argatroban with antiplatelet agents, thrombolytics, and other anticoagulants may increase the risk of bleeding.

Output: <Argatroban, effect, antiplatelet agents>, <Argatroban, effect, thrombolytics>, <Argatroban, effect, anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors.

Output: <NSAIDs, effect, Angiotensin Converting Enzyme (ACE) inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In patients with mild to moderate hypertension, administration of 25 mg daily of VIOXX with the ACE inhibitor benazepril, 10 to 40 mg for 4 weeks, was associated with an average increase in mean arterial pressure of about 3 mm Hg compared to ACE inhibitor alone.

Output: <VIOXX, effect, benazepril>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This interaction should be given consideration in patients taking VIOXX concomitantly with ACE inhibitors.

Output: <VIOXX, advise, ACE inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aspirin: Concomitant administration of low-dose aspirin with VIOXX may result in an increased rate of GI ulceration or other complications, compared to use of VIOXX alone.

Output: <aspirin, effect, VIOXX>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine: Co-administration with high doses of cimetidine [800 mg twice daily] increased the Cmax of rofecoxib by 21%, the AUC0-120hr by 23% and the t1/2 by 15%.

Output: <cimetidine, mechanism, rofecoxib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide: Clinical studies, as well as post-marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.

Output: <NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.

Output: <NSAIDs, mechanism, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Thus, when VIOXX and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Output: <VIOXX, advise, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: At higher than recommended doses, VIOXX 75 mg administered once daily for 10 days increased plasma concentrations by 23% as measured by AUC0-24hr in patients receiving methotrexate 7.5 to 15 mg/week for rheumatoid arthritis.

Output: <VIOXX, mechanism, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: At 24 hours postdose, a similar proportion of patients treated with methotrexate alone (94%) and subsequently treated with methotrexate co-administered with 75 mg of rofecoxib (88%) had methotrexate plasma concentrations below the measurable limit (5 ng/mL).

Output: <methotrexate, mechanism, rofecoxib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Standard monitoring of methotrexate-related toxicity should be continued if VIOXX and methotrexate are administered concomitantly.

Output: <VIOXX, advise, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rifampin: Co-administration of VIOXX with rifampin 600 mg daily, a potent inducer of hepatic metabolism, produced an approximate 50% decrease in rofecoxib plasma concentrations.

Output: <VIOXX, mechanism, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Theophylline VIOXX 12.5, 25, and 50 mg administered once daily for 7 days increased plasma theophylline concentrations (AUC(0- )) by 38 to 60% in healthy subjects administered a single 300-mg dose of theophylline.

Output: <VIOXX, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Adequate monitoring of theophylline plasma concentrations should be considered when therapy with VIOXX is initiated or changed in patients receiving theophylline.

Output: <VIOXX, advise, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin: Anticoagulant activity should be monitored, particularly in the first few days after initiating or changing VIOXX therapy in patients receiving warfarin or similar agents, since these patients are at an increased risk of bleeding complications.

Output: <VIOXX, advise, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In single and multiple dose studies in healthy subjects receiving both warfarin and rofecoxib, prothrombin time (measured as INR) was increased by approximately 8% to 11%.

Output: <warfarin, effect, rofecoxib>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In post-marketing experience, bleeding events have been reported, predominantly in the elderly, in association with increases in prothrombin time in patients receiving VIOXX concurrently with warfarin.

Output: <VIOXX, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: DOSTINEX should not be administered concurrently with D2-antagonists, such as phenothiazines, butyrophenones, thioxanthines, or metoclopramide.

Output: <DOSTINEX, advise, phenothiazines>, <DOSTINEX, advise, butyrophenones>, <DOSTINEX, advise, thioxanthines>, <DOSTINEX, advise, metoclopramide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When lansoprazole was administered concomitantly with theophylline (CYP1A2, CYP3A), a minor increase (10%) in the clearance of theophylline was seen.

Output: <lansoprazole, mechanism, theophylline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nonetheless, individual patients may require additional titration of their theophylline dosage when lansoprazole is started or stopped to ensure clinically effective blood levels.

Output: <theophylline, advise, lansoprazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a single-dose crossover study examining lansoprazole 30 mg and omeprazole 20 mg each administered alone and concomitantly with sucralfate 1 gram, absorption of the proton pump inhibitors was delayed and their bioavailability was reduced by 17% and 16%, respectively, when administered concomitantly with sucralfate.

Output: <proton pump inhibitors, mechanism, sucralfate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Therefore, proton pump inhibitors should be taken at least 30 minutes prior to sucralfate.

Output: <proton pump inhibitors, advise, sucralfate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: therefore, it is theoretically possible that lansoprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g. ketoconazole, ampicillin esters, iron salts, digoxin).

Output: <lansoprazole, mechanism, ketoconazole>, <lansoprazole, mechanism, ampicillin>, <lansoprazole, mechanism, iron>, <lansoprazole, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Considerable caution should be exercised if PEGANONE is administered concurrently with Phenurone (phenacemide) since paranoid symptoms have been reported during therapy with this combination.

Output: <PEGANONE, advise, Phenurone>, <PEGANONE, advise, phenacemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A two-way interaction between the hydantoin antiepileptic, phenytoin, and the coumarin anticoagulants has been suggested.

Output: <hydantoin antiepileptic, int, phenytoin>, <hydantoin antiepileptic, int, coumarin anticoagulant>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Presumably, phenytoin acts as a stimulator of coumarin metabolism and has been reported to cause decreased serum levels of the coumarin anticoagulants and increased prothrombin-proconvertin concentrations.

Output: <phenytoin, mechanism, coumarin>, <phenytoin, mechanism, coumarin anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Conversely, the coumarin anticoagulants have been reported to increase the serum levels and prolong the serum half-life of phenytoin by inhibiting its metabolism.

Output: <coumarin anticoagulants, mechanism, phenytoin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution is therefore advised when administering PEGANONE to patients receiving coumarin anticoagulants.

Output: <PEGANONE, advise, coumarin anticoagulants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients on warfarin-type anticoagulant therapy may require dosage adjustment of the anticoagulant during and after griseofulvin therapy.

Output: <warfarin-type anticoagulant, advise, griseofulvin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant use of barbiturates usually depresses griseofulvin activity and may necessitate raising the dosage.

Output: <barbiturates, effect, griseofulvin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The concomitant administration of griseofulvin has been reported to reduce the efficacy of oral contraceptives and to increase the incidence of breakthrough bleeding.

Output: <griseofulvin, effect, contraceptives>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Probenecid : Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, angiotensin-converting enzyme inhibitors, aminosalicylic acid, barbiturates, benzodiazepines, bumetanide, clofibrate, methotrexate, famotidine, furosemide, nonsteroidal anti-inflammatory agents, theophylline, and zidovudine).

Output: <Probenecid, mechanism, acetaminophen>, <Probenecid, mechanism, acyclovir>, <Probenecid, mechanism, angiotensin-converting enzyme inhibitors>, <Probenecid, mechanism, aminosalicylic acid>, <Probenecid, mechanism, barbiturates>, <Probenecid, mechanism, benzodiazepines>, <Probenecid, mechanism, bumetanide>, <Probenecid, mechanism, clofibrate>, <Probenecid, mechanism, methotrexate>, <Probenecid, mechanism, famotidine>, <Probenecid, mechanism, furosemide>, <Probenecid, mechanism, nonsteroidal anti-inflammatory>, <Probenecid, mechanism, theophylline>, <Probenecid, mechanism, zidovudine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Zidovudine should either be temporarily discontinued or decreased by 50% when coadministered with probenecid on the day of VISTIDE infusion.

Output: <Zidovudine, advise, probenecid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nephrotoxic agents : Concomitant administration of VISTIDE and agents with nephrotoxic potential [e.g., intravenous aminoglycosides (e.g., tobramycin, gentamicin, and amikacin), amphotericin B, foscarnet, intravenous pentamidine, vancomycin, and non-steroidal anti-inflammatory agents] is contraindicated.

Output: <VISTIDE, advise, aminoglycosides>, <VISTIDE, advise, tobramycin>, <VISTIDE, advise, gentamicin>, <VISTIDE, advise, amikacin>, <VISTIDE, advise, amphotericin B>, <VISTIDE, advise, foscarnet>, <VISTIDE, advise, pentamidine>, <VISTIDE, advise, vancomycin>, <VISTIDE, advise, non-steroidal anti-inflammatory agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, interactions may be expected, and UROXATRAL should NOT be used in combination with other alpha-blockers.

Output: <UROXATRAL, advise, alpha-blockers>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Dimenhydrinate may decrease emetic response to apomorphine.

Output: <Dimenhydrinate, effect, apomorphine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Anticoagulants including coumarin derivatives, indandione derivatives, and platelet aggregation inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs), and aspirin may increase the risk of bleeding when administered concomitantly with ardeparin.

Output: <Anticoagulants, effect, ardeparin>, <platelet aggregation inhibitors, effect, ardeparin>, <nonsteroidal anti-inflammatory drugs, effect, ardeparin>, <NSAIDs, effect, ardeparin>, <aspirin, effect, ardeparin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins;

Output: <Cholestyramine, mechanism, fat soluble vitamins>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Phenytoin/Phenobarbital: The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism.

Output: <phenytoin, mechanism, calcitriol>, <phenobarbital, mechanism, calcitriol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia.

Output: <thiazides, effect, vitamin D>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias.

Output: <Vitamin D, advise, digitalis>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D.

Output: <Ketoconazole, mechanism, vitamin D>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.

Output: <vitamin D analogues, mechanism, corticosteroids>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.

Output: <Magnesium, advise, vitamin D>, <antacids, advise, vitamin D>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ERGAMISOL  (levamisole hydrochloride) has been reported to produce ANTABUSE-like side effects when given concomitantly with alcohol.

Output: <ERGAMISOL, effect, alcohol>, <levamisole hydrochloride, effect, alcohol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because of reports of prolongation of the prothrombin time beyond the therapeutic range in patients taking concurrent levamisole and warfarin sodium, it is suggested that the prothrombin time be monitored carefully, and the dose of warfarin sodium or other coumarin-like drugs should be adjusted accordingly, in patients taking both drugs.

Output: <levamisole, advise, warfarin sodium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Use with Allopurinol: The principal pathway for detoxification of azathioprine is inhibited by allopurinol.

Output: <azathioprine, mechanism, allopurinol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients receiving azathioprine and allopurinol concomitantly should have a dose reduction of azathioprine, to approximately 1/3 to 1/4 the usual dose.

Output: <azathioprine, advise, allopurinol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Use with Angiotensln Converting Enzyme Inhibitors: The use of angiotensin converting enzyme inhibitors to control hypertension in patients on azathioprine has been reported to induce severe leukopenia.

Output: <angiotensin converting enzyme inhibitors, effect, azathioprine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Alcohol - Although LEXAPRO did not potentiate the cognitive and motor effects of alcohol in a clinical trial, as with other psychotropic medications, the use of alcohol by patients taking LEXAPRO is not recommended.

Output: <psychotropic medications, advise, LEXAPRO>, <alcohol, advise, LEXAPRO>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin potentiated the risk of bleeding.

Output: <psychotropic drugs, effect, NSAID>, <psychotropic drugs, effect, aspirin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cimetidine - In subjects who had received 21 days of 40 mg/day racemic citalopram, combined administration of 400 mg/day cimetidine for 8 days resulted in an increase in citalopram AUC and Cmax of 43% and 39%, respectively.

Output: <citalopram, mechanism, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because lithium may enhance the serotonergic effects of escitalopram, caution should be exercised when LEXAPRO and lithium are coadministered.

Output: <lithium, effect, escitalopram>, <LEXAPRO, advise, lithium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pimozide and Celexa - In a controlled study, a single dose of pimozide 2 mg co-administered with racemic citalopram 40 mg given once daily for 11 days was associated with a mean increase in QTc values of approximately 10 msec compared to pimozide given alone.

Output: <pimozide, effect, citalopram>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sumatriptan - There have been rare postmarketing reports describing patients with weakness, hyperreflexia, and incoordination following the use of a selective serotonin reuptake inhibitor (SSRI) and sumatriptan.

Output: <selective serotonin reuptake inhibitor, effect, sumatriptan>, <SSRI, effect, sumatriptan>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: If concomitant treatment with sumatriptan and an SSRI (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, escitalopram) is clinically warranted, appropriate observation of the patient is advised.

Output: <sumatriptan, advise, SSRI>, <sumatriptan, advise, fluoxetine>, <sumatriptan, advise, fluvoxamine>, <sumatriptan, advise, paroxetine>, <sumatriptan, advise, sertraline>, <sumatriptan, advise, citalopram>, <sumatriptan, advise, escitalopram>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although trough citalopram plasma levels were unaffected, given the enzyme-inducing properties of carbamazepine, the possibility that carbamazepine might increase the clearance of escitalopram should be considered if the two drugs are coadministered.

Output: <carbamazepine, mechanism, escitalopram>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole - Combined administration of racemic citalopram (40 mg) and ketoconazole (200 mg) decreased the Cmax and AUC of ketoconazole by 21% and 10%, respectively, and did not significantly affect the pharmacokinetics of citalopram.

Output: <citalopram, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, there are limited in vivo data suggesting a modest CYP2D6 inhibitory effect for escitalopram, i.e., coadministration of escitalopram (20 mg/day for 21 days) with the tricyclic antidepressant desipramine (single dose of 50 mg), a substrate for CYP2D6, resulted in a 40% increase in Cmax and a 100% increase in AUC of desipramine.

Output: <escitalopram, mechanism, desipramine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Metoprolol - Administration of 20 mg/day LEXAPRO for 21 days in healthy volunteers resulted in a 50% increase in Cmax and 82% increase in AUC of the beta-adrenergic blocker metoprolol (given in a single dose of 100 mg).

Output: <LEXAPRO, mechanism, metoprolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant Administration with Racemic Citalopram Citalopram - Since escitalopram is the active isomer of racemic citalopram (Celexa), the two agents should not be coadministered.

Output: <escitalopram, advise, citalopram>, <escitalopram, advise, Celexa>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cytadren accelerates the metabolism of dexamethasone;

Output: <Cytadren, mechanism, dexamethasone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Aminoglutethimide diminishes the effect of coumarin and warfarin.

Output: <Aminoglutethimide, effect, coumarin>, <Aminoglutethimide, effect, warfarin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, appropriate monitoring of blood glucose should be performed when initiating EXTRANEAL in diabetic patients and insulin dosage should be adjusted if needed.

Output: <EXTRANEAL, advise, insulin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The hypotensive effect of sodium nitroprusside is augmented by that of most other hypotensive drugs, including ganglionic blocking agents, negative inotropic agents, and inhaled anesthetics.

Output: <sodium nitroprusside, effect, hypotensive drugs>, <sodium nitroprusside, effect, ganglionic blocking agents>, <sodium nitroprusside, effect, anesthetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: CNS-Active Drugs Ethanol An additive effect on psychomotor performance was seen with coadministration of eszopiclone and ethanol 0.70 g/kg for up to 4 hours after ethanol administration.

Output: <eszopiclone, effect, ethanol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Olanzapine: Coadministration of eszopiclone 3 mg and olanzapine 10 mg produced a decrease in DSST scores.

Output: <eszopiclone, effect, olanzapine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The AUC of eszopiclone was increased 2.2-fold by coadministration of ketoconazole, a potent inhibitor of CYP3A4, 400 mg daily for 5 days.

Output: <eszopiclone, mechanism, ketoconazole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs That Induce CYP3A4 (Rifampicin) Racemic zopiclone exposure was decreased 80% by concomitant useof rifampicin, a potent inducer of CYP3A4.

Output: <zopiclone, mechanism, rifampicin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents.

Output: <Clindamycin, effect, neuromuscular blocking agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antagonism has been demonstrated between clindamycin and erythromycin in vitro.

Output: <clindamycin, effect, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Concomitant administration of other sympathomimetic agents may potentiate the undesirable effects of FORADIL.

Output: <sympathomimetic agents, effect, FORADIL>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Monoamine Oxidase Inhibitors and Tricyclic Antidepressants: FORADIL should be administered with extreme caution in patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants because the action of formoterol on the cardiovascular system may be potentiated by these agents.

Output: <FORADIL, advise, monoamine oxidase inhibitors>, <FORADIL, advise, tricyclic antidepressants>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Corticosteroids, Methylxanthines and Diuretics: Concomitant treatment with xanthine derivatives, steroids, or diuretics may potentiate a possible hypokalemic effect of  beta2-agonists.

Output: <xanthine derivatives, effect, beta2-agonists.>, <steroids, effect, beta2-agonists.>, <diuretics, effect, beta2-agonists.>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: During administration of multiple oral doses of TAMBOCOR to healthy subjects stabilized on a maintenance dose of digoxin, a 13%-19% increase in plasma digoxin levels occurred at six hours postdose.

Output: <TAMBOCOR, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a study involving healthy subjects receiving TAMBOCOR and propranolol concurrently, plasma flecainide levels were increased about 20% and propranolol levels were increased about 30% compared to control values.

Output: <TAMBOCOR, mechanism, propranolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The effects of concomitant administration of TAMBOCOR and propranolol on the PR interval were less than additive.

Output: <TAMBOCOR, effect, propranolol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nevertheless, the possibility of additive negative inotropic effects of beta blockers and flecainide should be recognized.

Output: <beta blockers, effect, flecainide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Limited data in patients receiving known enzyme inducers ( phenytoin, phenobarbital, carbamazepine ) indicate only a 30% increase in the rate of flecainide elimination.

Output: <phenytoin, mechanism, flecainide>, <phenobarbital, mechanism, flecainide>, <carbamazepine, mechanism, flecainide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In healthy subjects receiving cimetidine (1 gm daily) for one week, plasma flecainide levels increased by about 30% and half-life increased by about 10%.

Output: <cimetidine, mechanism, flecainide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: When amiodarone is added to flecainide therapy, plasma flecainide levels may increase two-fold or more in some patients, if flecainide dosage is not reduced.

Output: <amiodarone, mechanism, flecainide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs that inhibit cytochrome P450IID6, such as quinidine , might increase the plasma concentrations of flecainide in patients that are on chronic flecainide therapy;

Output: <quinidine, mechanism, flecainide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because both of these drugs have negative inotropic properties and the effects of coadministration with TAMBOCOR are unknown, neither disopyramide nor verapamil should be administered concurrently with TAMBOCOR unless, in the judgment of the physician, the benefits of this combination outweigh the risks.

Output: <disopyramide, advise, TAMBOCOR>, <verapamil, advise, TAMBOCOR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be observed when anileridine is coadministered with other opioids, sedatives, phenothiazines, or anesthetics, as these agents may increase respiratory and circulatory depression.

Output: <anileridine, advise, opioids>, <anileridine, advise, sedatives>, <anileridine, advise, phenothiazines>, <anileridine, advise, anesthetics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Vasoconstrictors: D.H.E. 45  (dihydroergotamine mesylate) Injection, USP should not be used with peripheral vasoconstrictors because the combination may cause synergistic elevation of blood pressure.

Output: <D.H.E. 45, effect, peripheral vasoconstrictors>, <dihydroergotamine mesylate, effect, peripheral vasoconstrictors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sumatriptan: Sumatriptan has been reported to cause coronary artery vasospasm, and its effect could be additive with D.H.E. 45  (dihydroergotamine mesylate) Injection, USP.

Output: <Sumatriptan, effect, D.H.E. 45>, <Sumatriptan, effect, dihydroergotamine mesylate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Sumatriptan and D.H.E. 45  (dihydroergotamine mesylate) Injection, USP should not be taken within 24 hours of each other..

Output: <Sumatriptan, advise, D.H.E. 45>, <Sumatriptan, advise, dihydroergotamine mesylate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Beta Blockers: Although the results of a clinical study did not indicate a safe problem associated with the administration of D.H.E. 45  (dihydroergotamine mesylate) Injection, USP to subjects already receiving propranolol, there have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine.

Output: <propranolol, effect, ergotamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Nicotine: Nicotine may provoke vasoconstriction in some patients, predisposing to a greater ischemic response to ergot therapy.

Output: <Nicotine, effect, ergot>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Macrolide Antibiotics (e. g. erythromycin and troleandomycin): Agents of the ergot alkaloid class, of which D.H.E. 45  (dihydroergotamine mesylate) Injection, USP is a member, have been shown to interact with antibiotics of the macrolide class, resulting in increased plasma levels of unchanged alkaloids and peripheral vasoconstriction.

Output: <ergot alkaloid class, mechanism, macrolide class>, <D.H.E. 45, mechanism, macrolide class>, <dihydroergotamine mesylate, mechanism, macrolide class>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Vasospastic reactions have been reported with therapeutic doses of ergotamine-containing drugs when co-administered with these antibiotics.

Output: <ergotamine, effect, antibiotics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: SSRIs: Weakness hyperreflexia, and incoordination have been reported rarely when 5-HT1 agonists have been co-administered with SSRIs (e. g.

Output: <5-HT1 agonists, effect, SSRIs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a study in which patients with active RA were treated for up to 24 weeks with concurrent Kineret and etanercept therapy, a 7% rate of serious infections was observed, which was higher than that observed with etanercept alone (0%).

Output: <Kineret, effect, etanercept>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Two percent of patients treated concurrently with Kineret and etanercept developed neutropenia (ANC  1 x 109/L).

Output: <Kineret, effect, etanercept>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: With oral dapsone treatment, folic acid antagonists such as pyrimethamine have been noted to possibly increase the likelihood of hematologic reactions

Output: <dapsone, effect, folic acid antagonists>, <dapsone, effect, pyrimethamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs That Should Not Be Coadministered With VIRACEPT Antiarrhythmics: amiodarone, quinidine Antihistamines: astemizole, terfenadine Antimigraine: ergot derivatives Antimycobacterial agents: rifampin Benzodiazepines midazolam, triazolam GI motility agents: cisapride

Output: <VIRACEPT, advise, Antiarrhythmics>, <VIRACEPT, advise, amiodarone>, <VIRACEPT, advise, quinidine>, <VIRACEPT, advise, Antihistamines>, <VIRACEPT, advise, astemizole>, <VIRACEPT, advise, terfenadine>, <VIRACEPT, advise, ergot derivatives>, <VIRACEPT, advise, Antimycobacterial agents>, <VIRACEPT, advise, rifampin>, <VIRACEPT, advise, Benzodiazepines>, <VIRACEPT, advise, midazolam>, <VIRACEPT, advise, triazolam>, <VIRACEPT, advise, cisapride>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drugs Which Require a Dose Reduction When Coadminstered With VIRACEPT Antimycobacterial agents: rifabutin

Output: <VIRACEPT, advise, Antimycobacterial agents>, <VIRACEPT, advise, rifabutin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: therefore, VIRACEPT should not be administered concurrently with terfenadine because of the potential for serious and/or life-threatening cardiac arrhythmias.

Output: <VIRACEPT, advise, terfenadine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Because a similar interaction is likely, VIRACEPT should also not be administered concurrently with astemizole.

Output: <VIRACEPT, advise, astemizole>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Indinavir: Coadministration of indinavir with VIRACEPT resulted in an 83% increase in nelfinavir plasma AUC and a 51% increase in indinavir plasma A.C.

Output: <indinavir, mechanism, VIRACEPT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ritonavir: Coadministration of ritonavir with VIRACEPT resulted in a 152% increase in nelfinavir plasma AUC and very little change in ritonavir plasma A.C.

Output: <ritonavir, mechanism, VIRACEPT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Saquinavir: Coadministration of saquinavir (using an experimental soft-gelatin capsule formulation of saquinavir 1200mg) with VIRACEPT resulted in an 18% increase in nelfinavir plasma AUC and a 4-fold increase in saquinavir plasma A.C.

Output: <saquinavir, mechanism, VIRACEPT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ketoconazole: Coadministration of ketoconazole with VIRACEPT resulted in a 35% increase in nelfinavir plasma A.C.

Output: <ketoconazole, mechanism, VIRACEPT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: therefore, nelfinavir should be administered (with food) one hour after or more than two hours before didanosine.

Output: <nelfinavir, advise, didanosine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: A dose adjustment is not needed when zidovudine is administered with VIRACEPT.

Output: <zidovudine, advise, VIRACEPT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rifabutin: Coadministration of rifabutin and VIRACEPT resulted in a 32% decrease in nelfinavir plasma AUC and a 207% increase in rifabutin plasma A.C.

Output: <rifabutin, mechanism, VIRACEPT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: It is recommended that the dose of rifabutin be reduced to one-half the usual dose when administered with VIRACEPT.

Output: <rifabutin, advise, VIRACEPT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Rifampin: Coadministration of rifampin and VIRACEPT resulted in an 82% decrease in nelfinavir plasma A.C.

Output: <rifampin, mechanism, VIRACEPT>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: VIRACEPT and rifampin should not be coadministered.

Output: <VIRACEPT, advise, rifampin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Ethinyl Estradiol and Norethindrone: Coadministration of VIRACEPT with OVCON-35 resulted in a 47% decrease in ethinyl estradiol and an 18% decrease in norethindrone plasma concentrations.

Output: <VIRACEPT, mechanism, OVCON-35>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In an in vitro study in human liver microsomes, inhibition of CYP2A6 hydroxylation of coumarin by fondaparinux (200 m m M i.e., 350 mg/L) was 17-28%.

Output: <coumarin, mechanism, fondaparinux>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Taking a rauwolfia alkaloid while you are taking or within 2 weeks of taking MAO inhibitors may increase the risk of central nervous system depression or may cause a severe high blood pressure reaction.

Output: <rauwolfia alkaloid, effect, MAO inhibitors>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tissue culture and animal studies indicate that ELSPAR can diminish or abolish the effect of methotrexate on malignant cells.14 This effect on methotrexate activity persists as long as plasma asparagine levels are suppressed.

Output: <ELSPAR, effect, methotrexate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: These results would seem to dictate against the clinical use of methotrexate with ELSPAR, or during the period following ELSPAR therapy when plasma asparagine levels are below normal.

Output: <methotrexate, advise, ELSPAR>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Metoclopramide: When coadministered with MONUROL, metoclopramide, a drug which increases gastrointestinal motility, lowers the serum concentration and urinary excretion of fosfomycin.

Output: <MONUROL, mechanism, metoclopramide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Etonogestrel may interact with the following medications: acetaminophen (Tylenol), antibiotics such as ampicillin and tetracycline, anticonvulsants (Dilantin, Phenobarbital, Tegretol, Trileptal, Topamax, Felbatol), antifungals (Gris-PEG, Nizoral, Sporanox), atorvastatin (Lipitor), clofibrate (Atromid-S), cyclosporine (Neoral, Sandimmune), HIV drugs classified as protease inhibitors (Agenerase, Crixivan, Fortovase, Invirase, Kaletra, Norvir, Viracept), morphine (Astramorph, Kadian, MS Contin), phenylbutazone, prednisolone (Prelone), rifadin (rifampin), St. Johns wort, temazepam, theophylline (Theo-Dur), and vitamin C.

Output: <Etonogestrel, int, acetaminophen>, <Etonogestrel, int, Tylenol>, <Etonogestrel, int, antibiotics>, <Etonogestrel, int, ampicillin>, <Etonogestrel, int, tetracycline>, <Etonogestrel, int, anticonvulsants>, <Etonogestrel, int, Dilantin>, <Etonogestrel, int, Phenobarbital>, <Etonogestrel, int, Tegretol>, <Etonogestrel, int, Trileptal>, <Etonogestrel, int, Topamax>, <Etonogestrel, int, Felbatol>, <Etonogestrel, int, antifungals>, <Etonogestrel, int, Gris-PEG>, <Etonogestrel, int, Nizoral>, <Etonogestrel, int, Sporanox>, <Etonogestrel, int, atorvastatin>, <Etonogestrel, int, Lipitor>, <Etonogestrel, int, clofibrate>, <Etonogestrel, int, Atromid-S>, <Etonogestrel, int, cyclosporine>, <Etonogestrel, int, Neoral>, <Etonogestrel, int, Sandimmune>, <Etonogestrel, int, protease inhibitors>, <Etonogestrel, int, Agenerase>, <Etonogestrel, int, Crixivan>, <Etonogestrel, int, Fortovase>, <Etonogestrel, int, Invirase>, <Etonogestrel, int, Kaletra>, <Etonogestrel, int, Norvir>, <Etonogestrel, int, Viracept>, <Etonogestrel, int, morphine>, <Etonogestrel, int, Astramorph>, <Etonogestrel, int, Kadian>, <Etonogestrel, int, MS Contin>, <Etonogestrel, int, phenylbutazone>, <Etonogestrel, int, prednisolone>, <Etonogestrel, int, Prelone>, <Etonogestrel, int, rifadin>, <Etonogestrel, int, rifampin>, <Etonogestrel, int, temazepam>, <Etonogestrel, int, theophylline>, <Etonogestrel, int, Theo-Dur>, <Etonogestrel, int, vitamin C>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: For example, when vitamin K antagonists are administered concomitantly with nilutamide, prothrombin time should be carefully monitored and if necessary, the dosage of vitamin K antagonists should be reduced.

Output: <vitamin K antagonists, advise, nilutamide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In a study in which the 2 mg clonazepam orally disintegrating tablet was administered with and without propantheline (an anticholinergic agent with multiple effects on the GI tract) to healthy volunteers, the AUC of clonazepam was 10% lower and the Cmax of clonazepam was 20% lower when the orally disintegrating tablet was given with propantheline compared to when it was given alone.

Output: <clonazepam, mechanism, propantheline>, <clonazepam, mechanism, propantheline>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital, induce clonazepam metabolism, causing an approximately 30% decrease in plasma clonazepam levels.

Output: <phenytoin, mechanism, clonazepam>, <carbamazepine, mechanism, clonazepam>, <phenobarbital, mechanism, clonazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam.

Output: <antifungal agents, advise, clonazepam>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Pharmacodynamic Interactions: The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.

Output: <benzodiazepine class, effect, alcohol>, <benzodiazepine class, effect, narcotics>, <benzodiazepine class, effect, barbiturates>, <benzodiazepine class, effect, nonbarbiturate hypnotics>, <benzodiazepine class, effect, antianxiety agents>, <benzodiazepine class, effect, phenothiazines classes of antipsychotic agents>, <benzodiazepine class, effect, thioxanthene classes of antipsychotic agents>, <benzodiazepine class, effect, butyrophenone classes of antipsychotic agents>, <benzodiazepine class, effect, monoamine oxidase inhibitors>, <benzodiazepine class, effect, tricyclic antidepressants>, <benzodiazepine class, effect, anticonvulsant drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Human growth hormone - Concomitant use of L-glutamine and human growth hormone may enhance nutrient absorption in those with severe short bowel syndrome.

Output: <L-glutamine, mechanism, human growth hormone>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Indomethacin - Concomitant use of L-glutamine and indomethacin may ameliorate increased intestinal permeability caused by indomethacin.

Output: <L-glutamine, effect, indomethacin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Methotrexate - There is one report that methotrexate may decrease the possible effectiveness of supplemental L-glutamine for chemotherapy-induced mucositis.

Output: <methotrexate, effect, L-glutamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: In another report, nine patients with breast cancer were reported to have decreased symptoms of methotrexate-related toxicity when given supplemental L-glutamine at a dose of 0.5 gram/kilogram/day.

Output: <methotrexate, effect, L-glutamine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Paclitaxel - In one report, L-glutamine at a dose of 10 grams three times daily, given 24 hours after receiving paclitaxel, appeared to prevent the development of myalgia and arthralgia, adverse reactions of paclitaxel.

Output: <L-glutamine, effect, paclitaxel>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Fenfluramine may increase slightly the effect of antihypertensive drugs, e.g., guanethidine, methyldopa, reserpine.

Output: <Fenfluramine, effect, antihypertensive drugs>, <Fenfluramine, effect, guanethidine>, <Fenfluramine, effect, methyldopa>, <Fenfluramine, effect, reserpine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Other CNS depressant drugs should be used with caution in patients taking fenfluramine, since the effects may be additive.

Output: <CNS depressant drugs, advise, fenfluramine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, co  administration of fexofenadine hydrochloride with either ketoconazole or erythromycin led to increased plasma concentrations of fexofenadine.

Output: <fexofenadine hydrochloride, mechanism, ketoconazole>, <fexofenadine hydrochloride, mechanism, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: These studies indicate that ketoconazole or erythromycin co-administration enhances fexofenadine gastrointestinal absorption.

Output: <ketoconazole, mechanism, fexofenadine>, <erythromycin, mechanism, fexofenadine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: This observed increase in the bioavailability of fexofenadine may be due to transport-related effects, such as p-glycoprotein. in vivo animal studies also suggest that in addition to enhancing absorption, ketoconazole decreases fexofenadine gastrointestinal secretion, while erythromycin may also decrease biliary excretion.

Output: <ketoconazole, mechanism, fexofenadine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Drug Interactions with Antacids Administration of 120 mg of fexofenadine hydrochloride (2 x 60 mg capsule) within 15 minutes of an aluminum and magnesium containing antacid (Maalox ) decreased fexofenadine AUC by 41% and cmax by 43%.

Output: <fexofenadine hydrochloride, mechanism, aluminum>, <fexofenadine hydrochloride, mechanism, magnesium>, <fexofenadine hydrochloride, mechanism, antacid>, <fexofenadine hydrochloride, mechanism, Maalox>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: ALLEGRA should not be taken closely in time with aluminum and magnesium containing antacids.

Output: <ALLEGRA, advise, aluminum>, <ALLEGRA, advise, magnesium>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients receiving other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, tricyclic antidepressants or other CNS depressants (including alcohol) concomitantly with DILAUDID may exhibit an additive CNS depression.

Output: <narcotic analgesic, effect, DILAUDID>, <anesthetics, effect, DILAUDID>, <phenothiazines, effect, DILAUDID>, <tranquilizers, effect, DILAUDID>, <sedative-hypnotics, effect, DILAUDID>, <tricyclic antidepressants, effect, DILAUDID>, <CNS depressants, effect, DILAUDID>, <alcohol, effect, DILAUDID>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Antacid: When atorvastatin and Maalox TC suspension were coadministered, plasma concentrations of atorvastatin decreased approximately 35%.

Output: <atorvastatin, mechanism, Maalox TC>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Colestipol: Plasma concentrations of atorvastatin decreased approximately 25% when colestipol and atorvastatin were coadministered.

Output: <colestipol, mechanism, atorvastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: However, LDL-C reduction was greater when atorvastatin and colestipol were coadministered than when either drug was given alone.

Output: <atorvastatin, effect, colestipol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Digoxin: When multiple doses of atorvastatin and digoxin were coadministered, steady-state plasma digoxin concentrations increased by approximately 20%.

Output: <atorvastatin, mechanism, digoxin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Erythromycin: In healthy individuals, plasma concentrations of atorvastatin increased approximately 40% with coadministration of atorvastatin and erythromycin, a known inhibitor of cytochrome P450 3A4.

Output: <atorvastatin, mechanism, erythromycin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Oral Contraceptives: Coadministration of atorvastatin and an oral contraceptive increased AUC values for norethindrone and ethinyl estradiol by approximately 30% and 20%.

Output: <atorvastatin, mechanism, contraceptive>, <atorvastatin, mechanism, norethindrone>, <atorvastatin, mechanism, ethinyl estradiol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: These increases should be considered when selecting an oral contraceptive for a woman taking atorvastatin.

Output: <contraceptive, advise, atorvastatin>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Caution should be exercised if an HMG-CoA reductase inhibitor is administered concomitantly with drugs that may decrease the levels or activity of endogenous steroid hormones, such as ketoconazole, spironolactone, and cimetidine.

Output: <HMG-CoA reductase inhibitor, advise, ketoconazole>, <HMG-CoA reductase inhibitor, advise, spironolactone>, <HMG-CoA reductase inhibitor, advise, cimetidine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Before taking glimepiride, tell your doctor if you are taking any of the following medicines: - aspirin or another salicylate such as magnesium/choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan), or bismuth subsalicylate (Pepto-Bismol);

Output: <glimepiride, advise, aspirin>, <glimepiride, advise, salicylate>, <glimepiride, advise, magnesium/choline salicylate>, <glimepiride, advise, Trilisate>, <glimepiride, advise, salsalate>, <glimepiride, advise, Disalcid>, <glimepiride, advise, choline salicylate>, <glimepiride, advise, Arthropan>, <glimepiride, advise, magnesium salicylate>, <glimepiride, advise, Magan>, <glimepiride, advise, bismuth subsalicylate>, <glimepiride, advise, Pepto-Bismol>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: HEMABATE may augment the activity of other oxytocic agents.

Output: <HEMABATE, effect, oxytocic agents>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function.

Output: <Furosemide, effect, aminoglycoside antibiotics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity.

Output: <Furosemide, advise, ethacrynic acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients receiving high doses of salicylates concomitantly with furosemide, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.

Output: <salicylates, effect, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine.

Output: <Furosemide, effect, tubocurarine>, <Furosemide, effect, succinylcholine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Lithium generally should not be given with diuretics because they reduce lithiums renal clearance and add a high risk of lithium toxicity.

Output: <Lithium, advise, diuretics>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide may add to or potentiate the therapeutic effect of other antihypertensive drugs.

Output: <Furosemide, effect, antihypertensive drugs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Furosemide may decrease arterial responsiveness to norepinephrine.

Output: <Furosemide, effect, norepinephrine>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tablets Simultaneous administration of sucralfate and furosemide tablets may reduce the natriuretic and antihypertensive effects of furosemide.

Output: <sucralfate, effect, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: The intake of furosemide and sucralfate should be separated by at least two hours.

Output: <furosemide, advise, sucralfate>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Tablets, Injection, and Oral Solution One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency.

Output: <furosemide, effect, acetylsalicylic acid>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs.

Output: <furosemide, effect, NSAIDs>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis.

Output: <indomethacin, effect, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Patients receiving both indomethacin and furosemide should be observed closely to determine if the desired diuretic and/or antihypertensive effect of furosemide is achieved.

Output: <indomethacin, advise, furosemide>


Instruction: Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Input: Warfarin: Meclofenamate sodium enhances the effect of warfarin.

Output: <Warfarin, effect, Meclofenamate sodium>