passages.id: split_1_test_2011_passage
passages.type: progene_text
passages.text: In human osteoblasts ( SaM-1 cells ) treated with 10 microg / ml LPS , increases in IL-6 mRNA and synthesis were inhibited by anti - CD14 antibody ( MEM-18 ) , PD98059 ( an inhibitor of classic mitogen - activated protein kinase [ MAPK ] ) , or SB203580 ( an inhibitor of p38 MAPK ) but were not inhibited by H-89 ( an inhibitor of protein kinase A [ PKA ] ) and calphostin C ( an inhibitor of protein kinase C [ PKC ] ) .