passages.id: split_1_test_63_passage
passages.type: progene_text
passages.text: In vitro , SHIP catalyzes the conversion of the phosphoinositide 3-kinase ( PI3K ) product phosphatidylinositol 3,4 , 5-trisphosphate ( PIP3 ) into phosphatidylinositol 3,4-bisphosphate .