passages.id: split_1_test_891_passage
passages.type: progene_text
passages.text: Transient transfection studies in mouse corticotroph AtT-20 cells demonstrated that internal deletion of the nGRE (-278 to - 249 nucleotides ) within the context of 1 kb of the intact CRH promoter resulted in decreased 8-BrcAMP stimulation and glucocorticoid - dependent repression of CRH promoter activity .