passages.id: split_1_test_979_passage
passages.type: progene_text
passages.text: Moreover , deletion of any one of the enhancer A control elements results in a dramatic loss of its inducibility by TNFalpha , and point mutations in either the EnA-TRE or the H2TF1 element lead to the loss of AP-1 / ATF or NF-kappaB binding , respectively , and to the loss of enhancer A inducibility .