passages.id: split_1_test_1566_passage
passages.type: progene_text
passages.text: Since c-FOS / AP-1 DNA - binding activity modulates both basal and inducible modes of PAI-1 gene control , and AP-1 motif binding factors were present in quiescent as well as stimulated NRK cells , a model of directionally regulated cell movement ( migration into scrape - denuded " wounds " ) was used to assess the consequences of c-fos transcript targeting on PAI-1 expression and cell motility .