passages.id: split_1_test_243_passage
passages.type: progene_text
passages.text: Exogenously administered mouse recombinant N - terminal protein of Ihh ( mrIhh - N ) upregulated the gene expression of type X collagen , a phenotypic marker of hypertrophic chondrocytes , as well as osteoprotegerin ligand ( OPGL ) , a potent stimulator of osteoclastogenesis and osteoclast activity , while it did not modulate the expression of Ihh itself , bone morphogenetic protein ( BMP ) - 4 , BMP-6 , transforming growth factor ( TGF ) - beta1 and TGF-beta2 in differentiated ATDC5 cells .