passages.id: split_1_test_176_passage
passages.type: progene_text
passages.text: AP-1 and CRE DNA binding activity correlated with the induction of CREB , CREMalpha and ATF-1 and CREB phosphorylation at ser133 ( ser133 phospho - CREB ) in the transition from basal to differentiating keratinocytes , but the activity of a CRE reporter remained unchanged .