passages.id: split_1_test_369_passage
passages.type: progene_text
passages.text: The functional roles of the putative gonadotrope - specific elements ( GSE ; consensus 5' - CTG ( A ) / ( T ) CCTTG - 3' ) residing at positions - 5 , - 134 , and - 396 were studied by site - directed mutagenesis , and it was found that only the mutation at position - 134 significantly reduced the promoter activity ( 80 % reduction ; P < 0.05 ) .