passages.id: split_1_test_291_passage
passages.type: progene_text
passages.text: Pretreatment with tetramethylpyrazine ( TMP , 12 mg / kg / day ) , a drug originally derived from the rhizomes of Ligusticum wallichii , significantly reduced the incidence of ischemia - induced ventricular tachycardia ( VT ) and fibrillation ( VF ) from 100 % and 50 % of control hearts to 41 % ( p < 0.05 ) and 0 % ( p < 0.05 ) , respectively , in the ischemic rat heart .