passages.id: split_1_test_2985_passage
passages.type: progene_text
passages.text: Substantial evidence indicates that the mechanism of KIR - mediated inhibition involves recruitment of the protein tyrosine phosphatases , Src homology 2 - containing protein tyrosine phosphatase-1 ( SHP-1 ) and SHP-2 , to two phosphorylated cytoplasmic immunoreceptor tyrosine - based inhibitory motifs ( ITIMs ) .