passages.id: split_1_test_2593_passage
passages.type: progene_text
passages.text: Thus , T cell - dependent B-cell activation via a CD40 pathway may cause a shift in the Th(1) / Th(2) balance to Th(2) dominance in Graves ' disease , while increased CD8 ( + ) cells in TL may suppress sCD23 production and IL-10 - producing Th(2) cells .