passages.id: split_1_test_1577_passage
passages.type: progene_text
passages.text: While the functionality of this AP-1 site in wound - regulated PAI-1 synthesis remains to be determined , antisense c-fos transcripts effectively attenuated PAI-1 induction and basal as well as growth factor - stimulated cell locomotion , indicating that expression of both the PAI-1 and c-fos genes is necessary for wound - initiated NRK cell migration .