passages.id: split_1_test_3381_passage
passages.type: progene_text
passages.text: Given the evidence for increased levels of activated astrocytes in the aged brain , the age - and AD - associated increases in NF-kappaB in brain may be significant contributors to increases in A beta , acting as a positive feedback loop of chronic inflammation , astrocyte activation , increased p65 / p50 activation of BACE1 transcription , and further inflammation .