passages.id: split_1_test_2113_passage
passages.type: progene_text
passages.text: A single nucleotide polymorphism ( SNP ) on intervening sequence ( IVS ) 8 ( IVS8 + 4 C / T ) was found to be strongly associated with the occurrence of NTG in both cohorts ( chi(2) = 7.97 , P = 0.005 in the first cohort , chi(2) = 9.93 , P = 0.002 in the second cohort ; odds ratio 3.1 ( 95 % CI : 1.8 - 5.6 ) . A second SNP ( IVS8 + 32 T / C ) appeared to be associated with disease in the first cohort ( chi(2) = 4.71 , P = 0.030 ) , but this finding could not be replicated in the second cohort .