text_1: TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.
text_2: The conformational change is elicited by cooperative rearrangements of two TCR-CD3 complexes and does not require accompanying changes in the structure of the TCRalphabeta ectodomains. This conformational change at CD3 reverts upon ligand dissociation and is required for T cell activation.