text: 27571702_9	With regards to its mechanism of action, AAFE inhibited the phosphorylation of Lck/yes  -related novel tyrosine kinase (Lyn), spleen tyrosine kinase (Syk), mitogen  -activated protein kinases (MAPKs), phosphoinositide 3  -kinase (PI3K)/Akt and IkBa, which have essential roles in the production of various cytokines in lymph nodes.