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Posttreatment self-reported hot flashes decreased 94%; physiologically measured hot flashes decreased 100%; and sleep quality improved 87.5%. | Significant improvements in overall sexual function, most reproductive hormones and in psychological status were maintained over two years following surgery. | 2 |
New theoretical investigations will be required to shed light onto these intriguing results. | They have a far more complex structure and composition than previously thought possible. | 2 |
In both databases the rate of est procedures performed showed steadily increasing use over time, with a sharp increase in the number of centers performing est in 2015. | While the rates of diagnostic ct did increase substantially during that time period, the changes varied considerably according to age group and anatomical region. | 2 |
Our findings suggest emotion regulatory effects of a short mindfulness intervention on a neurobiological level. | The effects on consumption may therefore represent a lower bound of efficacy of “ultra-brief” mindfulness instructions in hazardous drinkers, at least at short follow-up intervals. | 2 |
Our findings suggest emotion regulatory effects of a short mindfulness intervention on a neurobiological level. | Distinct cell populations in the hippocampus are required for reducing anxiety and for reducing fear. | 2 |
Our findings suggest emotion regulatory effects of a short mindfulness intervention on a neurobiological level. | Self-regulation did not influence NPS responses; instead, its effects were mediated through functional connections between the nucleus accumbens and ventromedial prefrontal cortex. | 1 |
Women who with the lowest serum levels of epa and dha -- 1.6 percent or less -- had a 10 times higher risk of early preterm birth when compared with women in the highest levels. | Pregnancy is a crucial period during which exposure to stress can negatively affect the health of both mother and baby. | 2 |
The nanoparticle treatment extended life just as well as the cisplatin treatment, and furthermore, that the combination therapy of the nanoparticles and cisplatin together extended life by about an additional 25 percent. | These results demonstrate the potential of the pH-responsive nanoparticle and the precise POLR2A targeted therapy in TNBC harbouring the common TP53 genomic alteration. | 1 |
The cells must pass through a stem cell-like state during the transformation from pericyte to neuron. | Not all neural stem cells respond to the oxygen deficiency. | 2 |
One in 10 regular marijuana users become dependent on the drug. | We found no evidence of a temporal relationship between cannabis use and pain severity or pain interference, and no evidence that cannabis use reduced prescribed opioid use or increased rates of opioid discontinuation. | 2 |
One in 10 regular marijuana users become dependent on the drug. | Marijuana is a gateway drug, that it makes one lazy and unproductive, and that marijuana leads to criminal behavior and is bad for the lungs ? well, no, there really is not. | 2 |
Hormonal contraceptives prevented 21 percent of ovarian cancers in the participants. | The drug olaparib (lynparza) could delay the return of advanced ovarian cancer in some woman whose cancer cells carry a faulty brca gene, or stopped the disease from getting worse. | 2 |
Hormonal contraceptives prevented 21 percent of ovarian cancers in the participants. | The current approach is not the only, or even the best way, to block the estrogen receptor. | 2 |
Pregnancy is a crucial period during which exposure to stress can negatively affect the health of both mother and baby. | Together, these studies confirm OGT as in important placental biomarker of maternal stress and demonstrate the profound impact a single placental gene has on long-term metabolic and neurodevelopmental programming that may be related to an increased risk for neurodevelopmental disorders. | 1 |
Some vaccines may have to be monitored more closely, he argues, or supported with extra measures to prevent unintended consequences. | Many parents indicated that they allow their children to receive only some vaccines because of concern about the way certain vaccines are produced. | 1 |
Individuals with a certain variant in a stress-controlling gene, called fkbp5, were more likely to develop chronic pain than those with other variants [1]. | Sometimes inflammation can transition to chronic pain with all the hallmarks of nerve injury -- a cellular event that involves tlr4. | 2 |
Individuals with a certain variant in a stress-controlling gene, called fkbp5, were more likely to develop chronic pain than those with other variants [1]. | GAT211 did not produce cardinal signs of direct CB 1 -receptor activation in the presence or absence of pathological pain. | 1 |
These periods of being alone may have positive impacts on emotional and work life. | Not all kinds of social withdrawal have negative effects. | 2 |
Prenatal marijuana exposure may impair fetal growth and brain development, less is known about the effects of marijuana on breastfeeding infants. | We found no evidence of a temporal relationship between cannabis use and pain severity or pain interference, and no evidence that cannabis use reduced prescribed opioid use or increased rates of opioid discontinuation. | 1 |
Among substance users, substance use disorders were not associated with on-time graduation. | Utilization of substance abuse treatment was significantly higher for the control group, but no differences were found in substance use or psychiatric symptoms. | 2 |
More than 200 commonly used prescription drugs, including hormonal birth control medications, blood pressure and heart medications, proton pump inhibitors, antacids and painkillers, have depression or suicide listed as potential side effects. | The choice of antidepressant medication can be guided by a blood sample that measures whether there is an inflammatory condition in the body. | 2 |
However, as single agents, these drugs had little effect on clonogenic potential. | Subcutaneous injection of 100 μmol/kg of these compounds caused no noticeable adverse effects in mic... | 2 |
However, as single agents, these drugs had little effect on clonogenic potential. | None was conclusively caused by mitragynine alone. | 2 |
However, as single agents, these drugs had little effect on clonogenic potential. | The agent had no significant impact on hMSC cell metabolic activity, proliferation, or pluripotency, and it increased the production of many paracrine factors implicated in cardiac repair. | 2 |
More exercise was not always better for psychological wellbeing, with people who exercise every day reporting lower levels of mental health. | Presence of depression and/or anxiety has a statistically and clinically significant negative impact on well being, but not on disability. | 2 |
More exercise was not always better for psychological wellbeing, with people who exercise every day reporting lower levels of mental health. | Additional research is required to understand the influence of exercise programs on a variety of cognitive functions. | 0 |
More exercise was not always better for psychological wellbeing, with people who exercise every day reporting lower levels of mental health. | In contrast, among controls, those who were depressed rated fewer activities as important, but exhibited few significant differences in the performance of activities. | 2 |
An experimental drug may hold promise as a potential treatment. | Subcutaneous injection of 100 μmol/kg of these compounds caused no noticeable adverse effects in mic... | 1 |
An experimental drug may hold promise as a potential treatment. | However, further rigorously designed trials on its use for other conditions are warranted. | 1 |
High-value riparian climate-corridors are least protected in flat, lowland areas, suggesting that such corridors should be high priorities for future conservation effort. | There are still many gaps in our knowledge of effects of climate change on biodiversity. | 1 |
P = .06) but no apparent benefit for patients with Child-Pugh scores of 6 or 7 and 8. | No statistically significant differences in QoL were found (one RCT). | 2 |
P = .06) but no apparent benefit for patients with Child-Pugh scores of 6 or 7 and 8. | The t-E 2 treatment was associated with a significant yet moderate improvement in the FSFI overall score across all time points compared with placebo (average efficacy, 2.6; 95% CI, 1.11-4.10; | 2 |
P = .06) but no apparent benefit for patients with Child-Pugh scores of 6 or 7 and 8. | As acknowledged in the article, validated biomarkers or companion diagnostics are not always present. | 2 |
P = .06) but no apparent benefit for patients with Child-Pugh scores of 6 or 7 and 8. | The practice does not have enough evidence to support its effectiveness. | 1 |
P = .06) but no apparent benefit for patients with Child-Pugh scores of 6 or 7 and 8. | At 1-year follow-up, there were no statistical differences between the experimental and control groups with regard to primary outcome measure of low back pain ( P = 0.183), leg pain ( P = 0.075), and function ( P = 0.365). | 2 |
P = .06) but no apparent benefit for patients with Child-Pugh scores of 6 or 7 and 8. | Additional research is warranted to confirm the results of this study in other samples and populations. | 1 |
P = .06) but no apparent benefit for patients with Child-Pugh scores of 6 or 7 and 8. | The treatment duration exerted no significant impact on symptom frequency (P > 0.05). | 2 |
P = .06) but no apparent benefit for patients with Child-Pugh scores of 6 or 7 and 8. | There was no significant between-group difference in the results, except for the papule count at week 4, which was -1.828 and 0.103 on the treated and nontreated sides, respectively. | 2 |
Neither bmi nor waist circumference nor percentage of body fat affected mortality rates when fitness was considered. | All other SNPs were not significantly associated with BMD. | 2 |
Neither bmi nor waist circumference nor percentage of body fat affected mortality rates when fitness was considered. | Psychometric properties did not differ on the basis of study quality, sample type (clinical vs. nonclinical) or sample age (child vs. adolescent). | 2 |
Neither bmi nor waist circumference nor percentage of body fat affected mortality rates when fitness was considered. | Total fat mass was not significantly different between the 4 beverage groups. | 2 |
Accelerated warming decades are characterized by rapid warming of globally averaged surface air temperature, greater increases of heat content in the upper ocean layers, an... | Time-varying perturbations for surface wind stress, temperature, and salinity are calculated from the difference between climate change and preindustrial control simulations, and are imposed on the ocean in separate simulations. | 2 |
Accelerated warming decades are characterized by rapid warming of globally averaged surface air temperature, greater increases of heat content in the upper ocean layers, an... | Continued warming to temperatures that now exceed the stable conditions of most of the Holocene epoch is likely to cause ice-shelf instability to encroach farther southward along the Antarctic Peninsula. | 2 |
Accelerated warming decades are characterized by rapid warming of globally averaged surface air temperature, greater increases of heat content in the upper ocean layers, an... | The trend matches neatly with models of human-influenced global warming, and thus cannot be attributed to natural variability. | 2 |
Accelerated warming decades are characterized by rapid warming of globally averaged surface air temperature, greater increases of heat content in the upper ocean layers, an... | Limiting the global mean temperature increase to 1.5deg celsius is neither a geophysical impossibility, nor a technical fantasy. | 2 |
Diagnostic blood samples were drawn for CO-oximetry Hb (CoOxHb) when the SpHb decreased by 1 g/dl or at the clinician’s discretion in the standard-care group. | At acute HA, Post p-mTORSer2448 and Post and REC p-p70S6KSer424/421 were not different from Base and lower than SL (P < 0.05... | 2 |
This is also modifiable by nutrients in the diet, such as by altering the carbohydrate/fat ratio or saturated/unsaturated fat ratio. | From baseline to week RT12, whole body muscle mass and protein-mineral mass were not changed, fat-free mass (P= 0.004) and total body water (P= 0.013) were decreased, and percentage body fat was increased (P= 0.011) in these weight-stable older people, independent of group assignment. | 2 |
This is also modifiable by nutrients in the diet, such as by altering the carbohydrate/fat ratio or saturated/unsaturated fat ratio. | There was no significant group difference in total change in adiposity, but abdominal adiposity decreased more (P = 0.049) in the capsinoid group (−1.11 ± 1.83%) than in the placebo group (−0.18 ± 1.94%), and this change correlated with the change in body weight (r = 0.46, P < 0.0001). | 2 |
Honeybees might outcompete wild bees by depleting common resources, possibly more so in simplified landscapes where flower-rich habitats have been lost. | Results: Range-restricted bees were involved in a significantly higher number of total interactions than regional and widespread native bees, but showed no evidence of increased generalisation. | 1 |
For every extra hour of moderate-to-vigorous physical activity, the teens fell asleep 18 minutes earlier, slept 10 minutes longer and had about one percent greater sleep maintenance efficiency that night. | Environmental cues had a very strong influence on daytime sleep behaviors. | 1 |
Cpeb4, a molecule that regulates protein synthesis, is impaired in most cases of autism. | Prenatal exposure to specific combinations of antibodies found only in mothers of children with autism leads to changes in the brain that adversely affect behavior and development. | 1 |
In all groups, the core language skill proved stable from infancy to adolescence, even after they accounted for child nonverbal intelligence and sociability and maternal age and education. | Larger effect sizes were indicated for some language constructs depending on either the operational definition of the language measure, the method of recording, the child's age level, the interaction partner (adult or peer), group size, gender composition, observational setting, or type of activity. | 2 |
Many parents indicated that they allow their children to receive only some vaccines because of concern about the way certain vaccines are produced. | Children whose parents used the phr in the northwest were 1.2 times more likely to receive their recommended immunizations; the results were statistically non-significant in hawaii. | 2 |
Nearly 40 percent of microbe-disease associations involve a species that did not previously have a genome. | While changes in microbial populations are apparent during these diseases, the species associated with each disease can vary from patient to patient. | 1 |
It should be noted that this retrospective study may underreport the true incidence of complications among these patients. | As acknowledged in the article, validated biomarkers or companion diagnostics are not always present. | 1 |
Exercise is an important part of preventing and treating migraines. | Migraine was not statistically significantly associated with an increased risk of alzheimer disease.overall, history of any headache was associated with an increased risk of all-cause dementia (relative risk [rr] = 1.24; 95% ci: 1.09-1.41), but there was considerable heterogeneity across studies. | 2 |
Organisms that occupy this ecosystem are a likely product of unique adaptations to an extreme environment that evolved during the last three to five million years when the Andes reached an altitude that was capable of sustaining this type of vegetation. | For tens of millions of years, saxifragales remained wallflowers, eking out a living in colder regions at the poles and at high elevations - scarce habitats in the predominantly tropical earth of the past. | 2 |
Organisms that occupy this ecosystem are a likely product of unique adaptations to an extreme environment that evolved during the last three to five million years when the Andes reached an altitude that was capable of sustaining this type of vegetation. | 150 of 2,710 species showed a statistically significant response to four environmental stages. | 1 |
Distinct cell populations in the hippocampus are required for reducing anxiety and for reducing fear. | Unbiased univariate analysis did not reveal differences in the hippocampus between remembering and imagining; however, multivariate analyses revealed evidence that patterns of activity within the hippocampus distinguish between remembering and imagining. | 2 |
Continued warming to temperatures that now exceed the stable conditions of most of the Holocene epoch is likely to cause ice-shelf instability to encroach farther southward along the Antarctic Peninsula. | Deep water is not forming in two key antarctic regions, they cannot actually say when a change in these regions occurred. | 1 |
People who got the flu had lower levels of immune cells called natural killer cells. | Is not the case with the highly pathogenic flu viruses that are associated with more severe illness. | 2 |
Sometimes inflammation can transition to chronic pain with all the hallmarks of nerve injury -- a cellular event that involves tlr4. | GAT211 did not produce cardinal signs of direct CB 1 -receptor activation in the presence or absence of pathological pain. | 1 |
We estimate for the planet a mass of 1.15 +- 0.04 Mjup and a radius of 1.26 +- 0.03 RJup. | Our dynamical results convincingly demonstrate that M67 could not have been the birth cluster of our solar system.« | 2 |
The incidence of scours or respiratory problems in calves did not differ between control Holsteins, other Holsteins, and backcrosses, nor did the incidence of mastitis, injury, or feet problems. | The healthy calves were also infected by a related, although less harmful, parasite species: theileria mutans or theileria velifera. | 1 |
Premedication with lorazepam did not significantly improve overall patient satisfaction as measured by evan-g, a validated patient satisfaction questionnaire (score of 72 (95% ci 70-73) for lorazepam vs. | Peer comparison letters led to statistically meaningful, persistent decreases in quetiapine prescribing, with no detected negative effects on patients. | 1 |
The system of peer-review, while not perfect, does give people in the scientific community room to change their preferences about the quality of work presented to them. | We demonstrate that this outcome is not unexpected because the level of consensus correlates with expertise in climate science. | 2 |
The MM group showed changes in TL that were intermediate between the LKM and control groups yet not significantly different from either. | No statistically significant differences in QoL were found (one RCT). | 2 |
The MM group showed changes in TL that were intermediate between the LKM and control groups yet not significantly different from either. | Psychometric properties did not differ on the basis of study quality, sample type (clinical vs. nonclinical) or sample age (child vs. adolescent). | 2 |
The MM group showed changes in TL that were intermediate between the LKM and control groups yet not significantly different from either. | The two groups did not differ significantly regarding disease-free and overall survival, and had similar rates of toxicities. | 2 |
Despite improvements on both the dual n-back and visual search tasks with practice, and despite a high level of statistical power, there was no positive transfer to any of the cognitive ability tests. | Interpretation The intervention had no significant effect on the NTB primary endpoint over 2 years in prodromal Alzheimer's disease. | 2 |
No statistically significant differences in QoL were found (one RCT). | There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | 2 |
No statistically significant differences in QoL were found (one RCT). | At 1-year follow-up, there were no statistical differences between the experimental and control groups with regard to primary outcome measure of low back pain ( P = 0.183), leg pain ( P = 0.075), and function ( P = 0.365). | 2 |
No statistically significant differences in QoL were found (one RCT). | When the to-be-ignored color changed from trial to trial, no RT benefit was observed. | 2 |
No statistically significant differences in QoL were found (one RCT). | Data showed no significant differences in salivary cortisol levels between baseline (0.51 μg/dL) and AAI sessions (0.44 μg/dL; p = 0.757). | 2 |
No statistically significant differences in QoL were found (one RCT). | Psychometric properties did not differ on the basis of study quality, sample type (clinical vs. nonclinical) or sample age (child vs. adolescent). | 2 |
No statistically significant differences in QoL were found (one RCT). | The treatment duration exerted no significant impact on symptom frequency (P > 0.05). | 2 |
No statistically significant differences in QoL were found (one RCT). | The two groups did not differ significantly regarding disease-free and overall survival, and had similar rates of toxicities. | 2 |
No statistically significant differences in QoL were found (one RCT). | There was no significant between-group difference in the results, except for the papule count at week 4, which was -1.828 and 0.103 on the treated and nontreated sides, respectively. | 2 |
No statistically significant differences in QoL were found (one RCT). | There was no difference (p=.6) in ease of procedure reported by providers. | 2 |
The t-E 2 treatment was associated with a significant yet moderate improvement in the FSFI overall score across all time points compared with placebo (average efficacy, 2.6; 95% CI, 1.11-4.10; | The treatment duration exerted no significant impact on symptom frequency (P > 0.05). | 2 |
Letrozole treatment did not significantly improve disease-free survival (339 disease-free survival events were reported in the placebo group and 292 disease-free survival events were reported in the letrozole group; hazard ratio 0·85, 95% CI 0·73–0·999; p=0·048). | At database lock and based on 92 deaths, no difference in overall survival was noted between linsitinib and placebo (median 323 days [95% CI 256–507] vs 356 days [249–556]; hazard ratio 0·94 [95% CI 0·61–1·44]; p=0·77). | 2 |
Letrozole treatment did not significantly improve disease-free survival (339 disease-free survival events were reported in the placebo group and 292 disease-free survival events were reported in the letrozole group; hazard ratio 0·85, 95% CI 0·73–0·999; p=0·048). | Letrozole is not superior to anastrazole as adjuvant endocrine therapy in this population. | 2 |
There is no relationship between the number of reviews a product has and its quality. | There was no relationship between the number of reviews and its rating. | 2 |
Caffeine is not responsible for the effect. | There was no increase in the motility index in any subject after a drink of hot water. | 2 |
As acknowledged in the article, validated biomarkers or companion diagnostics are not always present. | Receiver-operating characteristics (ROC) analysis using expression levels in each tissue and across tissues indicated significant but modest associations between elevated expression and phenotype for most tissues (maximum area under ROC curve = 0.69). | 2 |
As acknowledged in the article, validated biomarkers or companion diagnostics are not always present. | There was evidence that the association was not significantly altered by stage of liver disease or the presence/absence of high alcohol consumption, high body mass index, type 2 diabetes mellitus, smoking, or hepatitis B and C viruses. | 2 |
The protein is not actually necessary for the development and function of myeloid progenitor cells, either in vitro or in vivo in mice. | The hhex protein is overexpressed in acute myeloid leukemia (aml) cells and is necessary for their propagation but not for normal myelopoiesis. | 2 |
Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations. | Additional research is needed in this area. | 0 |
Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations. | Further study is warranted to elucidate the factors accounting for different outcomes in females and males. | 2 |
Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations. | Additional research is warranted to confirm the results of this study in other samples and populations. | 2 |
Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations. | The causal assumptions require further prospective or longitudinal studies on the topic. | 1 |
There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | All other SNPs were not significantly associated with BMD. | 2 |
There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | Participants in the psychosocial and no‐contact conditions did not show any significant improvement. | 2 |
There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | At 1-year follow-up, there were no statistical differences between the experimental and control groups with regard to primary outcome measure of low back pain ( P = 0.183), leg pain ( P = 0.075), and function ( P = 0.365). | 2 |
There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | When the to-be-ignored color changed from trial to trial, no RT benefit was observed. | 2 |
There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | There was no dose-response relationship between the amount of alcohol consumed and the presence of arthritis. | 2 |
There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | Data showed no significant differences in salivary cortisol levels between baseline (0.51 μg/dL) and AAI sessions (0.44 μg/dL; p = 0.757). | 2 |
There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | There were no group differences in the presence or number of infarcts, plaques, tangles, Lewy bodies, or amyloid angiopathy. | 2 |
There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | There was no difference in mammography utilization between Asians/Pacific Islanders and whites (OR = 1.82; 95% CI, 0.09-38.41). | 2 |
There were no statistically significant differences in change of scores for participants randomized to receive supplements vs those who were not. | There were no differences in all incident IHD events (0.95, 0.87–1.04). | 2 |