diff --git "a/DiseaseSpecific/generate_abstract/path/random_0.3_temp.json" "b/DiseaseSpecific/generate_abstract/path/random_0.3_temp.json" new file mode 100644--- /dev/null +++ "b/DiseaseSpecific/generate_abstract/path/random_0.3_temp.json" @@ -0,0 +1,400 @@ +The aim of this study was to assess the efficacy and safety of azathioprine in the treatment of pulmonary_sarcoidosis . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- . +This study investigated the clinical relevance of this finding by ascertaining whether Escherichia_coli isolated from the rectal swabs of 20 B27 + AS patients -LRB- B27 + AS + -RRB- and 46 controls -LRB- 35 B27 - AS - and 11 B27 + AS - -RRB- were able to absorb the lymphocytotoxic activity of these antisera . +The aim of this study was to determine whether the single nucleotide polymorphisms -LRB- SNPs -RRB- in the IL-33 gene are associated with susceptibility to AS in a Chinese population . +The changes of 8-hydroxy-desoxyguanosine -LRB- 8-HOdG -RRB- , interleukin-1 -LRB- IL-1 -RRB- , interleukin-6 -LRB- IL-6 -RRB- , interleukin-10 -LRB- IL-10 -RRB- , tumor_necrosis_factor-a -LRB- TNF-a -RRB- , intercellular_cell_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and high_mobility_group_box-1 protein -LRB- HMGB1 -RRB- in the cochlea were also examined . +Serum CTRP1 levels in all subjects and serum tumor_necrosis_factor-a -LRB- TNF-a -RRB- , interleukin-1b -LRB- IL-1b -RRB- , and interleukin-6 -LRB- IL-6 -RRB- levels in KD patients were measured using enzyme-linked immunosorbent assay.ResultsCompared with the HC group , serum CTRP1 levels were significantly elevated in the KD group . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +Generation of induced pluripotent stem cell line -LRB- ZZUi005-A -RRB- from a 21-year-old patient with a novel RAB39B gene mutation in X-linked_juvenile_parkinsonism . +RESULTS : Here , we show that transcript and protein levels as well as enzymatic activities of MMP-2_and _ -9 are markedly increased in the lungs of mice carrying the HPS Ap3b1 gene mutation . +Mean serum neopterin levels in SP and PMF patients -LRB- 10.72 + / - 0.98 nmol/L ; 14.08 + / - 3.86 nmol/L , respectively -RRB- were significantly higher than those of control group -LRB- 5.30 + / - 0.47 nmol/L -RRB- -LRB- P < 0.05 -RRB- . +HFS_LTD was blocked by the group I/II mGluR antagonist LY341495 -LRB- -LRB- 2S -RRB- -2-amino-2 - -LSB- -LRB- 1S , _ 2S -RRB- -2-carboxycycloprop-1-yl -RSB- -3 -LRB- xanth-9-yl -RRB- propanoic_acid -RRB- and by the mGluR5-selective antagonist 2-methyl-6 - -LRB- phenylethynyl -RRB- pyridine_hydrochloride -LRB- MPEP -RRB- . +Randomized , double-blind , placebo-controlled trial of tissue_plasminogen_activator in unstable_angina . +Furthermore , an intact STE20-related_proline-alanine-rich_kinase -LRB- SPAK -RRB- / oxidative stress response 1 kinase -LRB- OSR1 -RRB- pathway was found to be necessary for a WNK4 PHAII mutation to increase NCC phosphorylation and blood pressure in mice . +METHODS : This was a multicenter , randomized , double-blind , placebo-controlled study designed to determine the efficacy and safety of desloratadine in the treatment of moderate-to-severe CIU . +HOMA-IR , IL-6 , TNF-a , MDA and ox-LDL levels in patients with eclampsia were significantly higher than those in patients without eclampsia -LRB- p < 0.05 -RRB- , and the adiponectin_receptor_2 and COX-2 expression levels in the placental tissue were significantly higher than those in patients without eclampsia -LRB- p < 0.05 -RRB- . +Furthermore , an intact STE20-related_proline-alanine-rich_kinase -LRB- SPAK -RRB- / oxidative stress response 1 kinase -LRB- OSR1 -RRB- pathway was found to be necessary for a WNK4 PHAII mutation to increase NCC phosphorylation and blood pressure in mice . +Compared with non-use , metformin use was associated with a decreased risk of developing severe_dengue -LRB- adjusted risk ratio -LSB- aRR -RSB- = 0.60 , 95 % confidence interval -LSB- CI -RSB- : 0.37-0.98 , P = 0.04 -RRB- . +Biallelic loss-of-function mutations in the RNA-binding protein EIF4A3 cause Richieri-Costa-Pereira_syndrome -LRB- RCPS -RRB- , an autosomal recessive condition mainly characterized by craniofacial_and_limb_malformations . +Expression of seven genes of the anthocyanin biosynthetic pathway -LRB- phenylalanine ammonia lyase -LSB- PAL -RSB- , chalcone_synthase -LSB- CHS -RSB- , chalcone_isomerase -LSB- CHI -RSB- , flavanone-3-hydroxylase -LSB- F3H -RSB- , dihydroflavonol_4-reductase -LSB- DFR -RSB- , leucoanthocyanidin_dioxygen-ase -LSB- LDOX -RSB- , and UDP_glucose-flavonoid_3-o-glucosyl_transferase -LSB- UFGT -RSB- -RRB- was determined . +METHODS : Forty-two male Wistar albino rats -LRB- 250-300 g -RRB- were divided into 3 groups -LRB- Group A -LRB- n = 6 -RRB- , control group without electrical_burn_injury ; Groups B -LRB- n = 18 -RRB- and C -LRB- n = 18 -RRB- , electrical_burn_injury groups without and with fucoidin therapy , respectively -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +A double-blind , randomized , prospective , parallel-group study was conducted to evaluate the efficacy and safety of MTA in the treatment of asthmatic_crisis in children 2 to 6 years of age . +The aim of this study was to evaluate the clinical and hormonal effects of finasteride on hirsute women with idiopathic_hirsutism or polycystic_ovary_syndrome . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +We have typed genomic DNA for the presence of the putative KIR loci KIR2DL1 , KIR2DL2 , KIR2DL3 , KIR2DL4 , KIR3DL1 , KIR3DL2 , KIR3DL3 , KIR2DS1 , KIR2DS2 , KIR2DS3 , KIR2DS4 , KIR2DS5 , and KIR3DS1 using modified polymerase chain reaction sequence-specific primers . +Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout : a phase 3 , multicentre , randomized , double-blind , double-dummy , active-controlled , parallel-group study . +We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma . +These results indicated that the CCL28 chemokine and its receptors , CCR3 and CCR10 , are expressed at the maternal-conceptus interface , and CCL28 induces the proliferation and migration of trophectoderm cells through CCR10 , suggesting that CCL28 may play a critical role in the establishment and maintenance of pregnancy in pigs . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +To evaluate the relationship between the development of obesity and the hypersecretion of amylin by the pancreas , we examined the effects of 16.7 mmol/L glucose and 10 mmol/L arginine on the secretion of amylin and insulin by isolated perfused pancreata from genetically obese -LRB- fa/fa -RRB- and lean -LRB- Fa / ? -RRB- +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain . +Male Sprague-Dawley_rats were treated with a single intraperitoneal dose of cisplatin -LRB- 5 mg/kg -RRB- alone or combined with montelukast -LRB- Cys-LT receptor blocker , 10 mg/kg/day , orally -RRB- , or ONO-4057 -LRB- leukotriene_B4_receptor blocker , 300 mg/kg/day , orally -RRB- . +Current use of fluoroquinolones was associated with a statistically significantly increased risk of aortic_dissection -LRB- OR , 2.79 ; 95 % confidence interval -LSB- CI -RSB- , 2.31-3.37 ; I2 = 0 % -RRB- and aortic_aneurysm -LRB- OR , 2.25 ; 95 % CI , 2.03-2.49 ; I2 = 0 % -RRB- in a fixed-effects meta-analysis . +METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement . +The present study investigated the effects of systemic administration of the putative dopamine_D3_receptor agonist 7-hydroxy-N , N-di-n-propyl-2-aminotetralin -LRB- 7-OH-DPAT -RRB- on the acquisition and expression of morphine-induced place preference in male Wistar_rats . +We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls . +We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +This study examined a pathogenic role of PLA2R in airway inflammation using PLA2R-deficient -LRB- PLA2R -LRB- - / - -RRB- -RRB- mice . +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +Here , we screen the largest cohort of unexplained LIS patients examined to date to determine : -LRB- i -RRB- the frequency of TUBA1A mutations in patients with lissencephaly , -LRB- ii -RRB- the spectrum of phenotypes associated with TUBA1A mutations and -LRB- iii -RRB- the functional consequences of different TUBA1A mutations on microtubule function . +We have shown that non-Alp GBS differ from Alp GBS in the region surrounding the insertion site of Alp genes of Alp GBS as well as in their content of other surface proteins and that PCR for the upstream flanking region of the Alp gene may be useful for differentiation between Alp and non-Alp GBS . +To evaluate the relationship between the development of obesity and the hypersecretion of amylin by the pancreas , we examined the effects of 16.7 mmol/L glucose and 10 mmol/L arginine on the secretion of amylin and insulin by isolated perfused pancreata from genetically obese -LRB- fa/fa -RRB- and lean -LRB- Fa / ? -RRB- +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +There was a correlation between serum levels of alkaline phosphatase -LRB- r = 0.3 , p less than 0.01 -RRB- , phosphate -LRB- r = 0.42 , p less than 0.01 -RRB- and serum osteocalcin levels . +Here , we screen the largest cohort of unexplained LIS patients examined to date to determine : -LRB- i -RRB- the frequency of TUBA1A mutations in patients with lissencephaly , -LRB- ii -RRB- the spectrum of phenotypes associated with TUBA1A mutations and -LRB- iii -RRB- the functional consequences of different TUBA1A mutations on microtubule function . +INTRODUCTION : Mutations in GNAL have been associated with adult-onset cranio-cervical_dystonia , but a limited number of cases have been reported so far and the clinical spectrum associated with this gene still needs to be fully characterized . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +Here , we screen the largest cohort of unexplained LIS patients examined to date to determine : -LRB- i -RRB- the frequency of TUBA1A mutations in patients with lissencephaly , -LRB- ii -RRB- the spectrum of phenotypes associated with TUBA1A mutations and -LRB- iii -RRB- the functional consequences of different TUBA1A mutations on microtubule function . +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +BACKGROUND : The purpose of this study was to assess the efficacy and safety of fluoxetine in the treatment of binge-eating_disorder . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +We have typed genomic DNA for the presence of the putative KIR loci KIR2DL1 , KIR2DL2 , KIR2DL3 , KIR2DL4 , KIR3DL1 , KIR3DL2 , KIR3DL3 , KIR2DS1 , KIR2DS2 , KIR2DS3 , KIR2DS4 , KIR2DS5 , and KIR3DS1 using modified polymerase chain reaction sequence-specific primers . +We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma . +However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- . +Male Sprague-Dawley_rats were treated with a single intraperitoneal dose of cisplatin -LRB- 5 mg/kg -RRB- alone or combined with montelukast -LRB- Cys-LT receptor blocker , 10 mg/kg/day , orally -RRB- , or ONO-4057 -LRB- leukotriene_B4_receptor blocker , 300 mg/kg/day , orally -RRB- . +We determined the frequencies and properties of circulating CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- versus CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- cells in MG patients and healthy controls -LRB- HCs -RRB- , with special focus on the effect of thymectomy on CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- cells . +In this study , we elucidated the effects of four heavy metals , including cadmium -LRB- Cd -RRB- , mercury -LRB- Hg -RRB- , arsenic -LRB- As -RRB- , and lead -LRB- Pb -RRB- , on the activation of NLRP3 , NLRC4 , and AIM2 inflammasomes . +HOMA-IR , IL-6 , TNF-a , MDA and ox-LDL levels in patients with eclampsia were significantly higher than those in patients without eclampsia -LRB- p < 0.05 -RRB- , and the adiponectin_receptor_2 and COX-2 expression levels in the placental tissue were significantly higher than those in patients without eclampsia -LRB- p < 0.05 -RRB- . +In this work we have characterized DNA glycosylases NEIL1 and NEIL2 -LRB- Neil1 -LRB- - / - -RRB- / Neil2 -LRB- - / - -RRB- -RRB- double and NEIL1 , NEIL2 and NEIL3 -LRB- Neil1 -LRB- - / - -RRB- / Neil2 -LRB- - / - -RRB- / Neil3 -LRB- - / - -RRB- -RRB- triple knock-out mouse models . +Health-related quality of life outcomes with prasugrel among medically managed non-ST-segment elevation acute_coronary_syndrome patients : Insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes -LRB- TRILOGY ACS -RRB- trial . +Total EMP -LRB- CD42b -LRB- - -RRB- CD31 -LRB- + -RRB- -RRB- , pulmonary capillary EMP -LRB- CD42b -LRB- - -RRB- CD31 -LRB- + -RRB- ACE -LRB- + -RRB- -RRB- and apoptotic EMP -LRB- CD42b -LRB- - -RRB- CD62E -LRB- + -RRB- / CD42b -LRB- - -RRB- CD31 -LRB- + -RRB- -RRB- levels were quantified by flow cytometry . +A randomized , double-blind , placebo-controlled trial was performed to assess the efficacy of once daily budesonide in patients with nasal_polyps . +Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- . +Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain . +This study aimed at determining the relationship between vascular_endothelial_growth_factor-C -LRB- VEGF-C -RRB- , vascular_endothelial_growth_factor_receptor-3 -LRB- VEGFR-3 -RRB- , and contactin-1 -LRB- CNTN-1 -RRB- expression in gastric_cancer -LRB- GC -RRB- . +We investigated the effects of haloperidol -LRB- 0.1 mg/kg -RRB- and two selective D -LRB- 1 -RRB- antagonists , NNC_01-0112 -LRB- 0.05 , 0.1 and 0.2 mg/kg -RRB- and SCH_39166 -LRB- 0.02 , 0.2 and 2.0 mg/kg -RRB- , on latent_inhibition -LRB- LI -RRB- in rats . +Here , we report the crystal structures of the UBX domain of UBXD7 -LRB- UBXD7 -LRB- UBX -RRB- -RRB- at 2.0 resolution and its complex with p97 N-terminal domain -LRB- p97 -LRB- NTD -RRB- - UBXD7 -LRB- UBX -RRB- complex -RRB- at 2.4 resolution . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +OBJECTIVES : The aim of the study was to assess the concentrations of interleukin_1b -LRB- IL-1b -RRB- , IL-6 , IL-8 and transforming_growth_factor_b -LRB- TGF-b -RRB- in serum and in bronchoalveolar lavage fluid -LRB- BAL-f -RRB- in COP patients treated with clarithromycin -LRB- CAM -RRB- . +The efficacy , safety , and tolerance of pentoxifylline -LRB- Trental , Hoechst-Roussel Pharmaceuticals , Inc. -RRB- in the treatment of intermittent_claudication associated with chronic_occlusive_arterial_disease -LRB- COAD -RRB- were evaluated in a double-blind , placebo-controlled , parallel-group , multicenter clinical trial involving a total of 128 outpatients . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +In this study , we investigated the effects of hypoxic exposure and/or the administration of dexamethasone -LRB- Dex -RRB- , a synthetic GC on GILZ expression both in vitro and in vivo , and further explored the relationship between GILZ and proinflammatory cytokines IL-1b , IL-6 , and TNF-a under normoxic and hypoxic conditions . +Intracellular lipid droplets were detected by Oil-Red-O staining , and the expression of sterol_regulatory_element-binding_protein_1 -LRB- SREBP-1 -RRB- , Fatty_acid synthase -LRB- FAS -RRB- , Acetyl-CoA_carboxylase _ -LRB- ACC -RRB- _ 1_and_2 , Peroxisome_proliferator_activated_receptor-a -LRB- PPARa -RRB- , and carnitine_palmitoyl_transferase_1 -LRB- CPT-1 -RRB- was analyzed by real time reverse transcription-Polymerase chain reaction -LRB- qRT-PCR -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +In this study , we want to examine the effects of colchicine on platelet density , mean platelet volume -LRB- MPV -RRB- , neutrophil-lymphocyte ratio -LRB- NLR -RRB- , platelet-lymphocyte ratio -LRB- PLR -RRB- and red cell distribution width -LRB- RDW -RRB- of the patients with RAS . +On day 13 , 20 and 30 post immunization , the content of MDA in the EAE group was obviously higher than that in the control group -LRB- P < 0.05 -RRB- ; the content of MDA in the DXM group was obviously lower than that in the EAE group -LRB- P < 0.05 -RRB- . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +A double-blind , randomized , prospective , parallel-group study was conducted to evaluate the efficacy and safety of MTA in the treatment of asthmatic_crisis in children 2 to 6 years of age . +To the best of our knowledge , this is the first report of BRIP1 mutation in MBC in the Indian population . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Generation of induced pluripotent stem cell line -LRB- ZZUi005-A -RRB- from a 21-year-old patient with a novel RAB39B gene mutation in X-linked_juvenile_parkinsonism . +Adjusting for potential confounders , nicotine patch replacement therapy use was associated with a lower risk of prematurity -LRB- adjusted odds ratio , 0.21 , 95 % confidence interval , 0.13-0.34 -RRB- , and small-for-gestational-age -LRB- adjusted odds ratio , 0.61 , 95 % confidence interval , 0.41-0.90 -RRB- compared to smoking . +There was a marked increase in MuRF1 mRNA -LRB- P < 0.01 -RRB- 4 hours after LPS , and in atrogin-1 mRNA 4 hours -LRB- P < 0.01 -RRB- and 24 hours -LRB- P < 0.01 -RRB- after LPS . +However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Lopinavir was associated with a decreased risk of DILS -LRB- adjusted hazard ratio = 0.10 , 95 % confidence interval : 0.01 to 0.84 -RRB- , whereas zalcitabine was associated with an increased risk of DILS -LRB- adjusted hazard ratio = 13.7 , 95 % confidence interval : 2.18 to 85.9 -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls . +We first demonstrated that PKR plays a significant role in mediating LMP1-induced cytokine expression by using a PKR inhibitor 2-aminopurine , and the specific role of PKR involved was confirmed by the use of siRNA oligos targeting PKR and/or a dominant-negative PKR mutant . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +In this study , we want to examine the effects of colchicine on platelet density , mean platelet volume -LRB- MPV -RRB- , neutrophil-lymphocyte ratio -LRB- NLR -RRB- , platelet-lymphocyte ratio -LRB- PLR -RRB- and red cell distribution width -LRB- RDW -RRB- of the patients with RAS . +We analysed the expression of TET1 , TET2 , TET3 , IDH1 , IDH2 , IDH3a , and IDH3b in lesional and perilesional HS tissue as well as tissue from healthy controls by quantitative real-time reverse transcription polymerase chain reaction -LRB- RT-PCR -RRB- . +We investigated the effects of a 3-hydroxy-3-methylglutaryl_coenzyme_A -LRB- HMG-CoA -RRB- _ reductase inhibitor , pravastatin , an angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor , temocaprilat , and an angiotensin_II_type_1 _ -LRB- AT1 -RRB- _ receptor antagonist , CV-11974 , on myocardial metabolism during ischemia in isolated rabbit hearts using phosphorus 31-nuclear magnetic resonance -LRB- 31P-NMR -RRB- imaging . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +The inhibitory effect of wortmannin on Rap1B activation was overcome by addition of phosphatidylinositol_3,4,5-trisphosphate -LRB- PtdIns -LRB- 3,4,5 -RRB- P -LRB- 3 -RRB- -RRB- , but not PtdIns -LRB- 3,4 -RRB- P -LRB- 2 -RRB- , although both lipids were found to support phosphorylation of Akt . +We obtained primary cultures of mesangial cells from wild-type , doubly heterozygous -LRB- Col8a1 -LRB- + / - -RRB- / Col8a2 -LRB- + / - -RRB- -RRB- , and double-knockout -LRB- Col8a1 -LRB- - / - -RRB- / Col8a2 -LRB- - / - -RRB- -RRB- mice . +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +CONCLUSIONS : Identification of an MYH3 mutation in this family with distal_arthrogryposis_type_1 broadens the phenotype associated with MYH3 mutations to include distal_arthrogryposis_types_1 , 2A -LRB- Freeman-Sheldon_syndrome -RRB- , and 2B -LRB- Sheldon-Hall_syndrome -RRB- . +Our data show that sanguinarine treatment of PEL cells results in up-regulation of death_receptor_5 -LRB- DR5 -RRB- expression via generation of reactive oxygen species -LRB- ROS -RRB- and causes activation of caspase-8 and truncation of Bid -LRB- tBid -RRB- . +Unstimulated CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells from FIV -LRB- + -RRB- cats significantly suppress the proliferative response and the IL-2 production of Con A-stimulated autologous CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells compared with unstimulated CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells from FIV -LRB- - -RRB- cats . +This study aimed to investigate the protective effects of a cathepsin_B inhibitor -LRB- CA-074me -RRB- on lipopolysaccharide -LRB- LPS -RRB- / D-galactosamine -LRB- D-GalN -RRB- - induced acute_hepatic_failure -LRB- AHF -RRB- in mice . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Effect of eplerenone on parathyroid_hormone levels in patients with primary_hyperparathyroidism : a randomized , double-blind , placebo-controlled trial . +RESULTS : Two novel heterozygous mutations were discovered in the GATA-4 gene of patients with congenital_cardiac_septal_defects , His28Tyr in exon 2 and His436Tyr in exon 7 respectively , which were absent in the control population and not reported in the SNP database -LRB- http://www.ncbi.nlm.nih.gov/SNP -RRB- . +Serum cotinine levels were positively associated with rhinitis ever -LRB- AOR = 3.34 ; 95 % CI : 1.05-10.61 -RRB- and current rhinitis -LRB- AOR = 4.23 ; 95 % CI : 1.28-13.97 -RRB- among adolescents but not in children aged less than 10 years . +Serum CTRP1 levels in all subjects and serum tumor_necrosis_factor-a -LRB- TNF-a -RRB- , interleukin-1b -LRB- IL-1b -RRB- , and interleukin-6 -LRB- IL-6 -RRB- levels in KD patients were measured using enzyme-linked immunosorbent assay.ResultsCompared with the HC group , serum CTRP1 levels were significantly elevated in the KD group . +RESULTS : TOS , OSI levels and prolidase activity in patients with AA were found to be significantly higher compared to the control group -LRB- p = 0.02 , p = 0.004 , p < 0.001 , respectively -RRB- , whereas PON1 and arylesterase activities were significantly lower -LRB- p < 0.001 , p = 0.005 , respectively -RRB- . +The present study evaluated whether 2-deoxy-D-glucose -LRB- 2DG , 400 mg/kg -RRB- hyperphagia was affected by methysergide -LRB- 0.5-5 mg/kg -RRB- , ritanserin -LRB- 0.25-2.5 mg/kg -RRB- , or ICS-205,930 -LRB- 0.5-5 mg/kg -RRB- alone or in combination with naltrexone -LRB- 0.25 and 2.5 mg/kg -RRB- . +We also found that the inhibitory effects of 17b-E2 on Ca -LRB- 2 + -RRB- currents were unaffected by the estrogen receptor -LRB- ER -RRB- antagonist ICI_182780 ; however , the protein_kinase_C -LRB- PKC -RRB- inhibitor rottlerin and protein_kinase_A -LRB- PKA -RRB- inhibitor H-89 blocked the 17b-E2-induced inhibition of Ca -LRB- 2 + -RRB- currents . +We have typed genomic DNA for the presence of the putative KIR loci KIR2DL1 , KIR2DL2 , KIR2DL3 , KIR2DL4 , KIR3DL1 , KIR3DL2 , KIR3DL3 , KIR2DS1 , KIR2DS2 , KIR2DS3 , KIR2DS4 , KIR2DS5 , and KIR3DS1 using modified polymerase chain reaction sequence-specific primers . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +We have therefore studied mRNA levels for the alpha subunit of the CNTF_receptor -LRB- CNTFR_alpha -RRB- and for CNTF itself in postmortem spinal cord and cerebral cortex in patients with sporadic_ALS and matched controls . +RESULTS : The occurrence rate of esophageal_stricture in the PGA plus stent group was 20.5 % -LRB- n = 7 -RRB- , which was lower than that in the stent group -LRB- 46.9 % , n = 15 -RRB- -LRB- P = 0.024 -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- . +The 5-HT releaser fenfluramine , the 5-HT1A agonist 8-OH-DPAT , the 5-HT -LRB- 2A/1C -RRB- receptor agonist DOI and the 5-HT -LRB- 2A/1C -RRB- receptor antagonists ketanserin and mianserin reversed NECA-induced catalepsy . +The aim of this study was to assess the efficacy and safety of azathioprine in the treatment of pulmonary_sarcoidosis . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +In response to DNA damage or replication signals , a nuclear FA core complex of at least 6 FA proteins -LRB- FANCA , FANCC , FANCE , FANCF , FANCG and FANCL -RRB- is activated and leads to monoubiquitination of the downstream FA protein , FANCD2 . +To the best of our knowledge , this is the first published case of PR associated with bupropion use . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- , interleukin_18 -LRB- IL-18 -RRB- , and interleukin_10 -LRB- IL-10 -RRB- in elderly patients with ACS . +CONCLUSIONS : Identification of an MYH3 mutation in this family with distal_arthrogryposis_type_1 broadens the phenotype associated with MYH3 mutations to include distal_arthrogryposis_types_1 , 2A -LRB- Freeman-Sheldon_syndrome -RRB- , and 2B -LRB- Sheldon-Hall_syndrome -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Serum CTRP1 levels in all subjects and serum tumor_necrosis_factor-a -LRB- TNF-a -RRB- , interleukin-1b -LRB- IL-1b -RRB- , and interleukin-6 -LRB- IL-6 -RRB- levels in KD patients were measured using enzyme-linked immunosorbent assay.ResultsCompared with the HC group , serum CTRP1 levels were significantly elevated in the KD group . +The inhibitory effect of wortmannin on Rap1B activation was overcome by addition of phosphatidylinositol_3,4,5-trisphosphate -LRB- PtdIns -LRB- 3,4,5 -RRB- P -LRB- 3 -RRB- -RRB- , but not PtdIns -LRB- 3,4 -RRB- P -LRB- 2 -RRB- , although both lipids were found to support phosphorylation of Akt . +Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- . +To evaluate the effectiveness of thalidomide for epistaxis in hereditary_hemorrhagic_telangiectasia -LRB- HHT -RRB- , 7 HHT patients with recurrent epistaxis were treated with thalidomide at an initial dose of 50 mg/d , gradually increasing to 100 mg/d if needed . +The inhibitory effect of wortmannin on Rap1B activation was overcome by addition of phosphatidylinositol_3,4,5-trisphosphate -LRB- PtdIns -LRB- 3,4,5 -RRB- P -LRB- 3 -RRB- -RRB- , but not PtdIns -LRB- 3,4 -RRB- P -LRB- 2 -RRB- , although both lipids were found to support phosphorylation of Akt . +The inhibitory effect of wortmannin on Rap1B activation was overcome by addition of phosphatidylinositol_3,4,5-trisphosphate -LRB- PtdIns -LRB- 3,4,5 -RRB- P -LRB- 3 -RRB- -RRB- , but not PtdIns -LRB- 3,4 -RRB- P -LRB- 2 -RRB- , although both lipids were found to support phosphorylation of Akt . +Generation of induced pluripotent stem cell line -LRB- ZZUi005-A -RRB- from a 21-year-old patient with a novel RAB39B gene mutation in X-linked_juvenile_parkinsonism . +Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- . +However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- . +In summary , the present study identified a novel NHS mutation in a Chinese family with atypical_NHS ; the results broaden the known pathogenic mutation spectrum of NHS and will aid in the genetic counseling of patients with NHS . +Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- . +METHODS : This was a multicenter , open-label , single-arm , long-term phase III study in which patients with FD were given acotiamide , 100 mg t.i.d. , for 48 weeks . +BACKGROUND : This randomized , double-blind , placebo-controlled trial was designed to assess the efficacy and safety of topiramate in bulimia_nervosa . +The inhibitory effect of wortmannin on Rap1B activation was overcome by addition of phosphatidylinositol_3,4,5-trisphosphate -LRB- PtdIns -LRB- 3,4,5 -RRB- P -LRB- 3 -RRB- -RRB- , but not PtdIns -LRB- 3,4 -RRB- P -LRB- 2 -RRB- , although both lipids were found to support phosphorylation of Akt . +AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Our data show that sanguinarine treatment of PEL cells results in up-regulation of death_receptor_5 -LRB- DR5 -RRB- expression via generation of reactive oxygen species -LRB- ROS -RRB- and causes activation of caspase-8 and truncation of Bid -LRB- tBid -RRB- . +Odds ratios -LRB- ORs -RRB- and 95 % confidence intervals -LRB- CIs -RRB- were used to evaluate the risk of AACG associated with SSRI use . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- . +AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD . +METHODS : Bezafibrate -LRB- 400 mg/day -RRB- was orally administered to 7 consecutive patients with PSC , and we analyzed their clinical features and the drug efficacy in terms of the effect on hepatobiliary enzymes , including ALP , gamma-glutamyl_transpeptidase -LRB- gamma-GTP -RRB- , aspartate_aminotransferase -LRB- AST -RRB- , and alanine_aminotransferase -LRB- ALT -RRB- after 6 months . +OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee . +RESULTS : Pseudolaric_acid_B inhibited the growth of AGS cells in a time - and dose-dependent manner by arresting the cells at G -LRB- 2 -RRB- / M phase , which was accompanied with a decrease in the levels of cdc2 . +Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain . +We have examined the actions of SR_48968 -LRB- -LRB- S -RRB- - N-methyl-N - -LSB- 4 - -LRB- 4-acetylamino-4-phenyl_piperidino -RRB- -2 - -LRB- 3,4-dichlorophenyl -RRB- butyl -RSB- benzamide -RRB- , a novel non-peptide tachykinin NK-2-receptor antagonist , on the response evoked by electrical field stimulation or by acetylcholine and neurokinin A on guinea-pig isolated airway smooth muscle . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Aqueous humor outflow facility was measured by a two-level constant-pressure perfusion METHOD : PGE2 , ONO-AE1-259-01 -LRB- EP2 agonist -RRB- , and ONO-AE1-329 -LRB- EP4 agonist -RRB- significantly reduced IOP in a dose-dependent manner , whereas ONO-DI-004 -LRB- EP1 agonist -RRB- and ONO-AE-248 -LRB- EP3 agonist -RRB- had no effect . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +HOMA-IR , IL-6 , TNF-a , MDA and ox-LDL levels in patients with eclampsia were significantly higher than those in patients without eclampsia -LRB- p < 0.05 -RRB- , and the adiponectin_receptor_2 and COX-2 expression levels in the placental tissue were significantly higher than those in patients without eclampsia -LRB- p < 0.05 -RRB- . +METHODS AND RESULTS : Apolipoprotein_E-deficient -LRB- apoE - / - -RRB- mice fed a 1 % cholesterol diet were treated with a selective COX-1 inhibitor -LRB- SC-560 -RRB- , a selective COX-2 inhibitor -LRB- SC-236 -RRB- , or vehicle . +Serum CTRP1 levels in all subjects and serum tumor_necrosis_factor-a -LRB- TNF-a -RRB- , interleukin-1b -LRB- IL-1b -RRB- , and interleukin-6 -LRB- IL-6 -RRB- levels in KD patients were measured using enzyme-linked immunosorbent assay.ResultsCompared with the HC group , serum CTRP1 levels were significantly elevated in the KD group . +Using in vitro protein tyrosine phosphatase -LRB- PTPase -RRB- assays , we found that sodium_stibogluconate , a drug used in treatment of leishmaniasis , is a potent inhibitor of PTPases Src homology PTPase1 -LRB- SHP-1 -RRB- , SHP-2 , and PTP1B but not the dual-specificity phosphatase mitogen-activated protein kinase phosphatase 1 . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +This is a six-week , double-blind , placebo-controlled trial to determine the efficacy and safety of nitazoxanide in HIV-positive patients with cryptosporidiosis . +Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain . +The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- , interleukin_18 -LRB- IL-18 -RRB- , and interleukin_10 -LRB- IL-10 -RRB- in elderly patients with ACS . +These in vitro and in vivo data suggest that c-MET may be a potential therapeutic target in ASPS , and cabozantinib may be a particularly useful therapeutic option for patients with ASPS , including those with pazopanib-resistant ASPS . +The effects of NG-nitro-L-arginine -LRB- L-NNA -RRB- , a nitric_oxide -LRB- NO -RRB- synthase inhibitor , on renal vascular response to endothelin-3 -LRB- ET-3 -RRB- were studied in anesthetized dogs . +However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Mutation analysis of the inwardly rectifying K -LRB- + -RRB- channels KCNJ6 -LRB- GIRK2 -RRB- and KCNJ3 -LRB- GIRK1 -RRB- in juvenile_myoclonic_epilepsy . +Three CDK4/6 inhibitors -LRB- palbociclib , ribociclib , and abemaciclib -RRB- are available for women with hormone receptor-positive -LRB- HR + -RRB- , human epidermal_growth_factor_receptor_2-negative -LRB- HER2 - -RRB- advanced or metastatic breast_cancer . +HFS_LTD was blocked by the group I/II mGluR antagonist LY341495 -LRB- -LRB- 2S -RRB- -2-amino-2 - -LSB- -LRB- 1S , _ 2S -RRB- -2-carboxycycloprop-1-yl -RSB- -3 -LRB- xanth-9-yl -RRB- propanoic_acid -RRB- and by the mGluR5-selective antagonist 2-methyl-6 - -LRB- phenylethynyl -RRB- pyridine_hydrochloride -LRB- MPEP -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- . +Here , we screen the largest cohort of unexplained LIS patients examined to date to determine : -LRB- i -RRB- the frequency of TUBA1A mutations in patients with lissencephaly , -LRB- ii -RRB- the spectrum of phenotypes associated with TUBA1A mutations and -LRB- iii -RRB- the functional consequences of different TUBA1A mutations on microtubule function . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Loxapine -LRB- 0.3 mg/kg s.c. -RRB- , olanzapine -LRB- 10 mg/kg s.c. -RRB- and SCH_23390 -LRB- R - -LRB- + -RRB- - chloro-2 , 3 , 4 , 5-tetrahydro-3-methyl-5-phenyl-1-H-3-benzazepine ; 1 mg/kg , s.c. -RRB- , but not clozapine -LRB- 10 mg/kg , s.c. -RRB- , induced catalepsy in rats . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +The ENOs were totally blocked by the GABAA receptor antagonist bicuculline and they were also substantially reduced by the glutamatergic antagonists D,L-2-amino-5-phosphonovaleric _ acid -LRB- D , L-APV -RRB- and 6-cyano-7-nitroquinoxaline-2,3-dione -LRB- CNQX -RRB- . +RESULTS : The median duration of otorrhea in the prednisolone group was 1.0 days -LRB- 25 % to 75 % range , 1.0 to 2.0 days -RRB- , compared with 3.0 days -LRB- 25 % to 75 % range , 2.0 to 4.0 days -RRB- in the children receiving placebo -LRB- P < .001 -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Furthermore , the association of single nucleotide polymorphisms -LRB- SNPs -RRB- in the eotaxin-3 gene with CSS was determined in 161 CSS patients and 124 healthy controls . +METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement . +A binary logistic regression analysis showed that GLU -LRB- odds ratio -LSB- OR -RSB- , 5.052 ; P < 0.01 -RRB- and TC -LRB- OR , 1.074 ; P < 0.01 -RRB- may be risk factors for CP , whereas HDL-c may be a CP protective factor -LRB- OR , 0.833 ; P < 0.01 -RRB- . +METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +The present study evaluated whether 2-deoxy-D-glucose -LRB- 2DG , 400 mg/kg -RRB- hyperphagia was affected by methysergide -LRB- 0.5-5 mg/kg -RRB- , ritanserin -LRB- 0.25-2.5 mg/kg -RRB- , or ICS-205,930 -LRB- 0.5-5 mg/kg -RRB- alone or in combination with naltrexone -LRB- 0.25 and 2.5 mg/kg -RRB- . +To address this issue , we generated tenascin-X -LRB- TNX -RRB- and tenascin-C -LRB- TNC -RRB- double knockout mice and compared findings in these mice with those in single knockout -LRB- TNX + / + TNC - / - and TNX - / - TNC + / + -RRB- mice . +BACKGROUND : This randomized , double-blind , placebo-controlled trial was designed to assess the efficacy and safety of topiramate in bulimia_nervosa . +We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma . +Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain . +We aimed to assess the frequency of MKRN3 mutations in iCPP and to compare the phenotypes of patients with and without MKRN3 mutations . +A specific and selective nNOS inhibitor , 3-bromo-7-nitroindazole -LRB- 3-Br-7-NI ; 20 mg/kg/day , i.p. -RRB- , and a specific soluble_guanylate_cyclase -LRB- sGC -RRB- inhibitor , 1H - -LRB- 1,2,4 -RRB- oxadiazolo -LRB- 4,3-a -RRB- quinoxalin-1-one -LRB- ODQ ; 10 mg/kg/day , i.p. -RRB- , were administered during CUMS . +These in vitro and in vivo data suggest that c-MET may be a potential therapeutic target in ASPS , and cabozantinib may be a particularly useful therapeutic option for patients with ASPS , including those with pazopanib-resistant ASPS . +We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +This study describes the expression pattern of cytokines , interferon-gamma -LRB- IFN-gamma -RRB- , interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and IL-10 , produced by LPS stimulation in peripheral blood mononuclear cells -LRB- PBMCs -RRB- of the ferret -LRB- Mustela_putorius_furo -RRB- . +Serum CTRP1 levels in all subjects and serum tumor_necrosis_factor-a -LRB- TNF-a -RRB- , interleukin-1b -LRB- IL-1b -RRB- , and interleukin-6 -LRB- IL-6 -RRB- levels in KD patients were measured using enzyme-linked immunosorbent assay.ResultsCompared with the HC group , serum CTRP1 levels were significantly elevated in the KD group . +Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout : a phase 3 , multicentre , randomized , double-blind , double-dummy , active-controlled , parallel-group study . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +This study suggested that IL23R polymorphisms were associated with susceptibility to AS in the Chinese population and that IL23R may be involved in the development of AS . +However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +OBJECTIVE : The aim of this double-blind , placebo-controlled study was to evaluate the efficacy and tolerability of ziprasidone in the treatment of adult patients with borderline_personality_disorder . +We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +The present study evaluated whether 2-deoxy-D-glucose -LRB- 2DG , 400 mg/kg -RRB- hyperphagia was affected by methysergide -LRB- 0.5-5 mg/kg -RRB- , ritanserin -LRB- 0.25-2.5 mg/kg -RRB- , or ICS-205,930 -LRB- 0.5-5 mg/kg -RRB- alone or in combination with naltrexone -LRB- 0.25 and 2.5 mg/kg -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Identification of a novel nonsense mutation in the UNC13D gene from a patient with hemophagocytic_lymphohistiocytosis : a case report . +We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma . +On day 13 , 20 and 30 post immunization , the content of MDA in the EAE group was obviously higher than that in the control group -LRB- P < 0.05 -RRB- ; the content of MDA in the DXM group was obviously lower than that in the EAE group -LRB- P < 0.05 -RRB- . +BACKGROUND : Pregabalin is approved by the US Food and Drug Administration for the treatment of fibromyalgia -LRB- FM -RRB- , diabetic_peripheral_neuropathy -LRB- DPN -RRB- , postherpetic_neuralgia -LRB- PHN -RRB- , and neuropathic_pain due to spinal_cord_injury -LRB- SCI -RRB- . +In fact , rivaroxaban has been approved for the prevention of venous_thromboembolism after elective hip or knee replacement surgery , for the prevention and treatment of deep_vein_thrombosis and pulmonary_embolism , for the prevention of stroke in patients with nonvalvular atrial_fibrillation and for the prevention of atherothrombotic events after acute_coronary_syndrome with elevated cardiac biomarkers . +OBJECTIVES : The aim of the study was to assess the concentrations of interleukin_1b -LRB- IL-1b -RRB- , IL-6 , IL-8 and transforming_growth_factor_b -LRB- TGF-b -RRB- in serum and in bronchoalveolar lavage fluid -LRB- BAL-f -RRB- in COP patients treated with clarithromycin -LRB- CAM -RRB- . +The objective of this study was to compare the efficacy of flutamide and cyproterone_acetate in the treatment of hirsutism . +The concentration of sCD4 in patients with SSc were significantly lower -LRB- mean 6.2 U/ml -LRB- SD 3.8 -RRB- , median 5.0 U/ml -RRB- than in the normal subjects -LRB- mean 10.9 U/ml -LRB- SD 4.1 -RRB- , median 10.3 U/ml -RRB- . +This study suggested that IL23R polymorphisms were associated with susceptibility to AS in the Chinese population and that IL23R may be involved in the development of AS . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout : a phase 3 , multicentre , randomized , double-blind , double-dummy , active-controlled , parallel-group study . +Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout : a phase 3 , multicentre , randomized , double-blind , double-dummy , active-controlled , parallel-group study . +8-Hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin -LRB- 8-OH-DPAT -RRB- and buspirone , putative 5-HT1A agonists , m-trifluoromethylphenyl-piperazine -LRB- TFMPP -RRB- and 7-trifluoromethyl-4 -LRB- 4-methyl-1-piperazinyl -RRB- - pyrrolo -LRB- 1,2-1a -RRB- quinoxaline -LRB- CGS 12066B -RRB- , 5-HT1B agonists , and 5-carboxamidotryptamine -LRB- 5-CT -RRB- , a mixed 5-HT1A_and_5HT1B agonist , were used . +This study describes the expression pattern of cytokines , interferon-gamma -LRB- IFN-gamma -RRB- , interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and IL-10 , produced by LPS stimulation in peripheral blood mononuclear cells -LRB- PBMCs -RRB- of the ferret -LRB- Mustela_putorius_furo -RRB- . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +In summary , the present study identified a novel NHS mutation in a Chinese family with atypical_NHS ; the results broaden the known pathogenic mutation spectrum of NHS and will aid in the genetic counseling of patients with NHS . +On day 13 , 20 and 30 post immunization , the content of MDA in the EAE group was obviously higher than that in the control group -LRB- P < 0.05 -RRB- ; the content of MDA in the DXM group was obviously lower than that in the EAE group -LRB- P < 0.05 -RRB- . +We have shown that non-Alp GBS differ from Alp GBS in the region surrounding the insertion site of Alp genes of Alp GBS as well as in their content of other surface proteins and that PCR for the upstream flanking region of the Alp gene may be useful for differentiation between Alp and non-Alp GBS . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +The chemokine monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- and its receptor CCR2 have been shown to play an important role in the migration and trafficking of macrophages and Th1 effector cells in experimental autoimmune encephalomyelitis . +HOMA-IR , IL-6 , TNF-a , MDA and ox-LDL levels in patients with eclampsia were significantly higher than those in patients without eclampsia -LRB- p < 0.05 -RRB- , and the adiponectin_receptor_2 and COX-2 expression levels in the placental tissue were significantly higher than those in patients without eclampsia -LRB- p < 0.05 -RRB- . +Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- . +Double-blind , placebo-controlled trial of pirfenidone in patients with idiopathic_pulmonary_fibrosis . +Histamine -LRB- 1 mg kg -LRB- -1 -RRB- i.v. -RRB- , 5-HT -LRB- 0.1 mg kg -LRB- -1 -RRB- i.v. -RRB- and leukotriene_D -LRB- 4 -RRB- -LRB- LTD -LRB- 4 -RRB- , 50 microg kg -LRB- -1 -RRB- i.v. -RRB- caused a significant increase in microvascular_leakage in the airways . +The chemokine monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- and its receptor CCR2 have been shown to play an important role in the migration and trafficking of macrophages and Th1 effector cells in experimental autoimmune encephalomyelitis . +The chemokine monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- and its receptor CCR2 have been shown to play an important role in the migration and trafficking of macrophages and Th1 effector cells in experimental autoimmune encephalomyelitis . +Expression of seven genes of the anthocyanin biosynthetic pathway -LRB- phenylalanine ammonia lyase -LSB- PAL -RSB- , chalcone_synthase -LSB- CHS -RSB- , chalcone_isomerase -LSB- CHI -RSB- , flavanone-3-hydroxylase -LSB- F3H -RSB- , dihydroflavonol_4-reductase -LSB- DFR -RSB- , leucoanthocyanidin_dioxygen-ase -LSB- LDOX -RSB- , and UDP_glucose-flavonoid_3-o-glucosyl_transferase -LSB- UFGT -RSB- -RRB- was determined . +PPARalpha , PPARgamma , microsomal triglyceride transfer protein -LRB- MTP -RRB- , carnitine_palmitoyl transferase 1 -LRB- CPT-1 -RRB- , and sterol_regulatory_element_binding_protein-1c -LRB- SREBP-1c -RRB- mRNA were measured by quantitative RT-PCR . +Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- . +The compounds tested were the xanthine oxidase inhibitor allopurinol , the adenosine_deaminase inhibitor erythro-9 - -LRB- 2-hydroxy-3-nonyl -RRB- adenine -LRB- EHNA -RRB- and the adenosine uptake blocker S - -LRB- 4-nitrobenzyl -RRB- -6-thioinosine -LRB- NBTI -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +These results indicated that the CCL28 chemokine and its receptors , CCR3 and CCR10 , are expressed at the maternal-conceptus interface , and CCL28 induces the proliferation and migration of trophectoderm cells through CCR10 , suggesting that CCL28 may play a critical role in the establishment and maintenance of pregnancy in pigs . +OBJECTIVE : To determine whether serum interleukin_6 -LRB- IL-6 -RRB- , oncostatin_M -LRB- OSM -RRB- , soluble IL-6 receptor -LRB- sIL-6R -RRB- , and soluble gp130 -LRB- sgp130 -RRB- levels in patients with systemic_sclerosis -LRB- SSc -RRB- are elevated and whether they are correlated with the clinical or serological features of the disease . +METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout . +RESULTS : The expression of microRNA-451 in emigrant CMS patients was higher than that in emigrant healthy people -LRB- P < 0.05 -RRB- ; the expression of microRNA-451 in localized CMS patients was higher than that in localized healthy people -LRB- P < 0.05 -RRB- ; the microRNA-451 expression had no statistical difference between emargant and localized healthy people . +A specific and selective nNOS inhibitor , 3-bromo-7-nitroindazole -LRB- 3-Br-7-NI ; 20 mg/kg/day , i.p. -RRB- , and a specific soluble_guanylate_cyclase -LRB- sGC -RRB- inhibitor , 1H - -LRB- 1,2,4 -RRB- oxadiazolo -LRB- 4,3-a -RRB- quinoxalin-1-one -LRB- ODQ ; 10 mg/kg/day , i.p. -RRB- , were administered during CUMS . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +Here , we screen the largest cohort of unexplained LIS patients examined to date to determine : -LRB- i -RRB- the frequency of TUBA1A mutations in patients with lissencephaly , -LRB- ii -RRB- the spectrum of phenotypes associated with TUBA1A mutations and -LRB- iii -RRB- the functional consequences of different TUBA1A mutations on microtubule function . +We report a case of anaplastic_astrocytoma -LRB- WHO grade III -RRB- in an 18-month-old child with CSS due to a de novo germline missense SMARCE1 mutation . +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD . +We report a case of anaplastic_astrocytoma -LRB- WHO grade III -RRB- in an 18-month-old child with CSS due to a de novo germline missense SMARCE1 mutation . +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +In conclusion , we did not detect any known or likely pathogenic variants in the ISL1 gene in 125 Swedish BEEC patients , indicating that variation in the ISL1 gene is not a common genetic mechanism of BEEC development in the Swedish population . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +In this study , we want to examine the effects of colchicine on platelet density , mean platelet volume -LRB- MPV -RRB- , neutrophil-lymphocyte ratio -LRB- NLR -RRB- , platelet-lymphocyte ratio -LRB- PLR -RRB- and red cell distribution width -LRB- RDW -RRB- of the patients with RAS . +We report a case of anaplastic_astrocytoma -LRB- WHO grade III -RRB- in an 18-month-old child with CSS due to a de novo germline missense SMARCE1 mutation . +It was observed that the urine levels of TWEAK in patients with LN were significantly elevated compared with those in the other groups -LRB- P < 0.05 -RRB- . +The chemokine monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- and its receptor CCR2 have been shown to play an important role in the migration and trafficking of macrophages and Th1 effector cells in experimental autoimmune encephalomyelitis . +We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- . +We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls . +A randomized , double-blind , multicenter , placebo-controlled phase III trial to evaluate the efficacy and safety of pregabalin in Japanese patients with fibromyalgia . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +A double-blind , placebo-controlled study was performed to assess whether a new calcium antagonist , nisoldipine , in doses of either 5 mg or 10 mg daily , in combination with beta-adrenergic-blocking_drugs -LRB- combination therapy -RRB- was more effective than beta-adrenergic-blocking_drugs alone -LRB- single therapy -RRB- in the treatment of chronic_stable_angina . +A double-blind , placebo-controlled study was performed to assess whether a new calcium antagonist , nisoldipine , in doses of either 5 mg or 10 mg daily , in combination with beta-adrenergic-blocking_drugs -LRB- combination therapy -RRB- was more effective than beta-adrenergic-blocking_drugs alone -LRB- single therapy -RRB- in the treatment of chronic_stable_angina . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Health-related quality of life in young adults with congenital_central_hypoventilation_syndrome due to PHOX2B mutations : a cross-sectional study . +Aqueous humor outflow facility was measured by a two-level constant-pressure perfusion METHOD : PGE2 , ONO-AE1-259-01 -LRB- EP2 agonist -RRB- , and ONO-AE1-329 -LRB- EP4 agonist -RRB- significantly reduced IOP in a dose-dependent manner , whereas ONO-DI-004 -LRB- EP1 agonist -RRB- and ONO-AE-248 -LRB- EP3 agonist -RRB- had no effect . +The aim of this study was to assess the efficacy and safety of azathioprine in the treatment of pulmonary_sarcoidosis . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Analysis of Regulatory T Cell Subsets and Their Expression of Helios and PD-1 in Patients with Hashimoto_Thyroiditis . +Male Sprague-Dawley_rats were treated with a single intraperitoneal dose of cisplatin -LRB- 5 mg/kg -RRB- alone or combined with montelukast -LRB- Cys-LT receptor blocker , 10 mg/kg/day , orally -RRB- , or ONO-4057 -LRB- leukotriene_B4_receptor blocker , 300 mg/kg/day , orally -RRB- . +Furthermore , the association of single nucleotide polymorphisms -LRB- SNPs -RRB- in the eotaxin-3 gene with CSS was determined in 161 CSS patients and 124 healthy controls . +We have typed genomic DNA for the presence of the putative KIR loci KIR2DL1 , KIR2DL2 , KIR2DL3 , KIR2DL4 , KIR3DL1 , KIR3DL2 , KIR3DL3 , KIR2DS1 , KIR2DS2 , KIR2DS3 , KIR2DS4 , KIR2DS5 , and KIR3DS1 using modified polymerase chain reaction sequence-specific primers . +We performed a multicenter , randomized , placebo-controlled , double-blind , phase 3 trial to evaluate the efficacy and safety of prucalopride in children -LRB- 6-18 years old -RRB- with functional constipation . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Mutations in CRX , a photoreceptor-specific transcription factor , can cause Leber_congenital_amaurosis -LRB- LCA -RRB- , cone-rod_dystrophy -LRB- CORD -RRB- , and retinitis_pigmentosa -LRB- RP -RRB- , all of which feature severe visual_impairment . +BACKGROUND : Allopurinol is a frequent cause of severe_cutaneous_adverse_reactions -LRB- SCARs -RRB- , such as drug_reaction with eosinophilia and systemic symptoms -LRB- DRESS -RRB- , Stevens-Johnson_syndrome -LRB- SJS -RRB- and toxic_epidermal_necrolysis -LRB- TEN -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +METHODS : Thalidomide was given to 2 patients with EOS -LRB- a 16-year-old girl and an 8-year-old boy -RRB- at an initial dosage of 2 mg/kg/day , and the dosage was increased if necessary . +The inhibitory effect of wortmannin on Rap1B activation was overcome by addition of phosphatidylinositol_3,4,5-trisphosphate -LRB- PtdIns -LRB- 3,4,5 -RRB- P -LRB- 3 -RRB- -RRB- , but not PtdIns -LRB- 3,4 -RRB- P -LRB- 2 -RRB- , although both lipids were found to support phosphorylation of Akt . +Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment . +METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement . +BACKGROUND : The purpose of this study was to assess the efficacy and safety of fluoxetine in the treatment of binge-eating_disorder . +Mutations in the fukutin-related_protein gene -LRB- FKRP -RRB- are associated with a spectrum of diseases from mild limb-girdle_muscular_dystrophy type 2I to severe congenital_muscular_dystrophy type 1C , muscle-eye-brain_disease -LRB- MEB -RRB- , and Walker-Warburg_syndrome -LRB- WWS -RRB- . +A caspase-3 inhibitor z-VAD-FMK completely blocked the apoptosis , but a caspase-1 inhibitor -LRB- Ac-YVAD-CMK -RRB- and caspase-2 inhibitor -LRB- z-VDVAD-FMK -RRB- did not block the apoptosis , suggesting that caspase-3 might have a critical role in the execution process of apoptosis induced by RGD . +The adenosine_A2A_receptor antagonist , 1,3,7-trimethyl-8 - -LRB- 3-chlorostyryl -RRB- xanthine -LRB- CSC -RRB- , significantly decreased catalepsy induced by raclopride and haloperidol , while the adenosine A1 receptor antagonist , 1,3-dimethyl-8-phenylxanthine -LRB- 8-PT -RRB- , was ineffective . +This is the first report that a mutation in the LMX1B gene causes NPS in a Chinese population , which will expand the spectrum of mutations in the LMX1B gene and provide insight into the underlining pathology of NPS . +The effects of beraprost_sodium -LRB- BPS -RRB- , a stable prostacyclin analogue , on motor nerve conduction velocity and nerve blood flow of the sciatic nerve were investigated in streptozotocin-induced diabetic rats , and they were compared with the effects of epalrestat -LRB- aldose_reductase inhibitor -RRB- . +To our knowledge this is the second reported case of neonatal_diabetes in an infant with Klinefelter_syndrome and the first due to a mutation in the KCNJ11 in a patient with Klinefelter_syndrome . +The aim of this randomized double-blind , placebo-controlled , parallel-group study was to evaluate the efficacy , safety , and tolerability of pregabalin in combination with oxycodone or placebo , in patients with either postherpetic_neuralgia -LRB- PHN -RRB- or painful_diabetic_neuropathy -LRB- PDN -RRB- . +We have typed genomic DNA for the presence of the putative KIR loci KIR2DL1 , KIR2DL2 , KIR2DL3 , KIR2DL4 , KIR3DL1 , KIR3DL2 , KIR3DL3 , KIR2DS1 , KIR2DS2 , KIR2DS3 , KIR2DS4 , KIR2DS5 , and KIR3DS1 using modified polymerase chain reaction sequence-specific primers . +A phase 2 , randomized , double-blind , placebo-controlled , dose-ranging study to evaluate the efficacy and safety of orally administered VT-1161 in the treatment of recurrent vulvovaginal_candidiasis . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain . +We have shown that non-Alp GBS differ from Alp GBS in the region surrounding the insertion site of Alp genes of Alp GBS as well as in their content of other surface proteins and that PCR for the upstream flanking region of the Alp gene may be useful for differentiation between Alp and non-Alp GBS . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . +METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout . +METHODS : Thalidomide was given to 2 patients with EOS -LRB- a 16-year-old girl and an 8-year-old boy -RRB- at an initial dosage of 2 mg/kg/day , and the dosage was increased if necessary . +However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- . +OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +The aim of this study was to evaluate the effects of sodium_hypochlorite -LRB- NaOCl -RRB- , chlorhexidine_digluconate -LRB- CHX -RRB- , and mixture of tetracycline , citric_acid , and detergent -LRB- MTAD -RRB- solutions on the surfaces of nickel_titanium -LRB- NiTi -RRB- rotary files with scanning_electron_microscopy -LRB- SEM -RRB- and atomic force microscopy -LRB- AFM -RRB- . +Van_der_Woude_syndrome -LRB- VWS -RRB- and popliteal_pterygium_syndrome -LRB- PPS -RRB- are autosomal dominant clefting_disorders recently discovered to be caused by mutations in the IRF6 -LRB- Interferon_Regulatory_Factor_6 -RRB- gene . +We have shown that non-Alp GBS differ from Alp GBS in the region surrounding the insertion site of Alp genes of Alp GBS as well as in their content of other surface proteins and that PCR for the upstream flanking region of the Alp gene may be useful for differentiation between Alp and non-Alp GBS . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +The inhibitory effect of wortmannin on Rap1B activation was overcome by addition of phosphatidylinositol_3,4,5-trisphosphate -LRB- PtdIns -LRB- 3,4,5 -RRB- P -LRB- 3 -RRB- -RRB- , but not PtdIns -LRB- 3,4 -RRB- P -LRB- 2 -RRB- , although both lipids were found to support phosphorylation of Akt . +Unstimulated CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells from FIV -LRB- + -RRB- cats significantly suppress the proliferative response and the IL-2 production of Con A-stimulated autologous CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells compared with unstimulated CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells from FIV -LRB- - -RRB- cats . +Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- . +We will first describe the current knowledge on vesicular glutamate transporters -LRB- VGLUT1/2/3 -RRB- , the vesicular excitatory amino_acid transporter -LRB- VEAT -RRB- , the vesicular nucleotide transporter -LRB- VNUT -RRB- , vesicular monoamine transporters -LRB- VMAT1/2 -RRB- , the vesicular_acetylcholine_transporter -LRB- VAChT -RRB- and the vesicular y-aminobutyric_acid -LRB- GABA -RRB- transporter -LRB- VGAT -RRB- in the brain . +METHOD : The study was a randomized , double-blind , parallel-group , flexible-dose comparison of sertraline and placebo in outpatients with a DSM-III-R diagnosis of panic_disorder with or without agoraphobia . +It is concluded that acitretin is a highly effective and well-tolerated drug in the treatment of cutaneous_lupus_erythematosus . +Cidofovir has been officially approved for the treatment of cytomegalovirus_retinitis in AIDS patients , tenofovir_disoproxil_fumarate -LRB- Viread -RRB- for the treatment of HIV_infections -LRB- i.e. , AIDS -RRB- and adefovir_dipivoxil for the treatment of chronic hepatitis_B . +Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain . +PURPOSE : The purpose of this study was to determine whether fluocinolone inhibits vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in a retinal pigment epithelial cell line -LRB- ARPE-19 -RRB- and TNF-alpha-induced angiogenesis in chick_chorioallantoic_membrane -LRB- CAM -RRB- assay . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +In this work we have characterized DNA glycosylases NEIL1 and NEIL2 -LRB- Neil1 -LRB- - / - -RRB- / Neil2 -LRB- - / - -RRB- -RRB- double and NEIL1 , NEIL2 and NEIL3 -LRB- Neil1 -LRB- - / - -RRB- / Neil2 -LRB- - / - -RRB- / Neil3 -LRB- - / - -RRB- -RRB- triple knock-out mouse models . +Male Sprague-Dawley_rats were treated with a single intraperitoneal dose of cisplatin -LRB- 5 mg/kg -RRB- alone or combined with montelukast -LRB- Cys-LT receptor blocker , 10 mg/kg/day , orally -RRB- , or ONO-4057 -LRB- leukotriene_B4_receptor blocker , 300 mg/kg/day , orally -RRB- . +BACKGROUND : This randomized , double-blind , placebo-controlled trial was designed to assess the efficacy and safety of topiramate in bulimia_nervosa . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +The aim of this study was to evaluate the diagnostic value of combined detection of receptor-binding_cancer_antigen_expressed_on_SiSo_cells -LRB- RCAS1 -RRB- and carcinoembryonic_antigen -LRB- CEA -RRB- in patients with MPE and benign pleural_effusion -LRB- BPE -RRB- . +Mean serum levels of PP in patients with gastrinomas -LRB- 67 + / - 31 pmol/l -LRB- SD -RRB- -RRB- were significantly -LRB- P less than 0.01 -RRB- higher than in the normal subjects -LRB- 47 + / - 15 pmol/l -RRB- . +We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls . +However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- . +The adenosine_A2A_receptor antagonist , 1,3,7-trimethyl-8 - -LRB- 3-chlorostyryl -RRB- xanthine -LRB- CSC -RRB- , significantly decreased catalepsy induced by raclopride and haloperidol , while the adenosine A1 receptor antagonist , 1,3-dimethyl-8-phenylxanthine -LRB- 8-PT -RRB- , was ineffective . +In conclusion , our findings demonstrate that EGCG is effective for growth inhibition of synovial_sarcoma cell lines in vitro and suggest that EGCG may be a new therapeutic option for patients with synovial_sarcoma . +The pooled absolute rate of recurrent ischemic_stroke or TIA in patients with PFO was 4.0 events per 100 person-years -LRB- 95 % CI 3.0 to 5.1 -RRB- while the rate of recurrent ischemic_stroke was 1.6 events per 100 person-years -LRB- 95 % CI 1.1 to 2.1 -RRB- . +We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma . +Results of a double-blind , randomized , placebo-controlled , parallel study in 37 patients indicate that terfenadine , 60 mg bid , is significantly more effective than placebo and as effective as hydroxyzine , 25 mg qid , in the treatment of chronic_idiopathic_urticaria without causing the somnolence that was associated with the use of hydroxyzine . +This study explored the effect of pidotimod combined with azithromycin on children with mycoplasma_pneumonia and the expression of interleukin-10 -LRB- IL-10 -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in serum . +METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement . +We performed a multicenter , randomized , placebo-controlled , double-blind , phase 3 trial to evaluate the efficacy and safety of prucalopride in children -LRB- 6-18 years old -RRB- with functional constipation . +Mometasone_furoate was as effective as twice-daily beclomethasone_dipropionate or once-daily fluticasone_propionate in the treatment of perennial_allergic_rhinitis , and was as effective as twice-daily beclomethasone_dipropionate and slightly more effective than once-daily oral loratadine in the treatment of seasonal_allergic_rhinitis . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Cinacalcet HCl , an allosteric modulator of the calcium-sensing_receptor -LRB- CaR -RRB- , has recently been approved for the treatment of secondary_hyperparathyroidism in patients with chronic kidney_disease on dialysis , due to its suppressive effect on parathyroid_hormone -LRB- PTH -RRB- secretion . +The aim of this randomized double-blind , placebo-controlled , parallel-group study was to evaluate the efficacy , safety , and tolerability of pregabalin in combination with oxycodone or placebo , in patients with either postherpetic_neuralgia -LRB- PHN -RRB- or painful_diabetic_neuropathy -LRB- PDN -RRB- . +In conclusion , we did not detect any known or likely pathogenic variants in the ISL1 gene in 125 Swedish BEEC patients , indicating that variation in the ISL1 gene is not a common genetic mechanism of BEEC development in the Swedish population . +Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- . +The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- , interleukin_18 -LRB- IL-18 -RRB- , and interleukin_10 -LRB- IL-10 -RRB- in elderly patients with ACS . +In conclusion , we did not detect any known or likely pathogenic variants in the ISL1 gene in 125 Swedish BEEC patients , indicating that variation in the ISL1 gene is not a common genetic mechanism of BEEC development in the Swedish population . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +OBJECTIVES : The aim of the study was to assess the concentrations of interleukin_1b -LRB- IL-1b -RRB- , IL-6 , IL-8 and transforming_growth_factor_b -LRB- TGF-b -RRB- in serum and in bronchoalveolar lavage fluid -LRB- BAL-f -RRB- in COP patients treated with clarithromycin -LRB- CAM -RRB- . +There was no significant difference in the clinical effects of OFLX between cases of chlamydial_urethritis and those of non-chlamydial_urethritis . +OBJECTIVE : The aim of the present study was to explore the prognostic value of long non-coding RNA CPS1-IT1 -LRB- CPS1-IT1 -RRB- expression in epithelial ovarian cancer -LRB- EOC -RRB- patients and identify the effect of CPS1-IT1 on cell proliferation and apoptosis of EOC cells . +OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee . +METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement . +We have typed genomic DNA for the presence of the putative KIR loci KIR2DL1 , KIR2DL2 , KIR2DL3 , KIR2DL4 , KIR3DL1 , KIR3DL2 , KIR3DL3 , KIR2DS1 , KIR2DS2 , KIR2DS3 , KIR2DS4 , KIR2DS5 , and KIR3DS1 using modified polymerase chain reaction sequence-specific primers . +We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Loxapine -LRB- 0.3 mg/kg s.c. -RRB- , olanzapine -LRB- 10 mg/kg s.c. -RRB- and SCH_23390 -LRB- R - -LRB- + -RRB- - chloro-2 , 3 , 4 , 5-tetrahydro-3-methyl-5-phenyl-1-H-3-benzazepine ; 1 mg/kg , s.c. -RRB- , but not clozapine -LRB- 10 mg/kg , s.c. -RRB- , induced catalepsy in rats . +Furthermore , the association of single nucleotide polymorphisms -LRB- SNPs -RRB- in the eotaxin-3 gene with CSS was determined in 161 CSS patients and 124 healthy controls . +A double-blind , placebo-controlled study was performed to assess whether a new calcium antagonist , nisoldipine , in doses of either 5 mg or 10 mg daily , in combination with beta-adrenergic-blocking_drugs -LRB- combination therapy -RRB- was more effective than beta-adrenergic-blocking_drugs alone -LRB- single therapy -RRB- in the treatment of chronic_stable_angina . +CONCLUSIONS : Identification of an MYH3 mutation in this family with distal_arthrogryposis_type_1 broadens the phenotype associated with MYH3 mutations to include distal_arthrogryposis_types_1 , 2A -LRB- Freeman-Sheldon_syndrome -RRB- , and 2B -LRB- Sheldon-Hall_syndrome -RRB- . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +FGF23 causes hypophosphatemia by decreasing the expression of sodium_phosphate cotransporters -LRB- NaPi-2a and NaPi-2c -RRB- and decreasing serum 1,25 -LRB- OH -RRB- -LRB- 2 -RRB- Vitamin_D -LRB- 3 -RRB- levels . +METHODS : Forty-two male Wistar albino rats -LRB- 250-300 g -RRB- were divided into 3 groups -LRB- Group A -LRB- n = 6 -RRB- , control group without electrical_burn_injury ; Groups B -LRB- n = 18 -RRB- and C -LRB- n = 18 -RRB- , electrical_burn_injury groups without and with fucoidin therapy , respectively -RRB- . +METHODS : The concentrations of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , VEGF-C , and VEGF-D in serum and bronchoalveolar lavage fluid from 65 patients with pulmonary_sarcoidosis , 10 with idiopathic_pulmonary_fibrosis , and 29 healthy volunteers were measured by ELISA . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +Unstimulated CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells from FIV -LRB- + -RRB- cats significantly suppress the proliferative response and the IL-2 production of Con A-stimulated autologous CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells compared with unstimulated CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells from FIV -LRB- - -RRB- cats . +OBJECTIVE : The purpose of this study was to evaluate the efficacy and safety of ciclesonide in the treatment of perennial_allergic_rhinitis . +Furthermore , the expression of interleukin - -LRB- IL-2 -RRB- , IL-12 -LRB- p40 -RRB- , tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , interferon-gamma -LRB- IFN-gamma -RRB- , IL-10 and transforming growth factor-beta -LRB- TGF-beta -RRB- as well as inducible_nitric_oxid_synthase -LRB- iNOS -RRB- mRNA was determined by reverse transcription-polymerase chain reaction -LRB- RT-PCR -RRB- . +At 2 h after dosing , frovatriptan reduced the risk of nausea by 14 % -LRB- 95 % CI 6-20 % , P = 0.0005 -RRB- , photophobia 17 % -LRB- 95 % CI 12-22 % , P < 0.0001 -RRB- , and phonophobia 14 % -LRB- 95 % CI 17-20 % , P < 0.0001 -RRB- . +Serum levels of MMP19 in patients with silicosis were significantly higher than those in patients with coal_workers ' _ pneumoconiosis -LRB- P < 0.05 -RRB- . +In order to evaluate the efficacy of albendazole for the treatment of taeniasis , regimens of 400 mg x 1 day , 800 mg x 2 days , 800 mg x 3 days , 1200 mg x 2 days , and 1200 mg x 3 days were compared . +These enzymes included alcohol dehydrogenase -LRB- ADH -RRB- , alpha-glycerol-3-phosphate_dehydrogenase -LRB- alpha GPDH -RRB- , malate_dehydrogenase -LRB- MDH -RRB- , isocitrate_dehydrogenase -LRB- IDH -RRB- , glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- , 6-phosphogluconate_dehydrogenase -LRB- 6PGD -RRB- and alpha-amylase -LRB- AMY -RRB- . +We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls . +METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement . +OBJECTIVE : The purpose of this study was to assess the efficacy of fluvoxamine in the treatment of binge-eating_disorder . +MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks . +The purpose of this study was to evaluate the efficacy of sertraline in the treatment of pathological_gambling . +The purpose of this study was to evaluate the efficacy of sertraline in the treatment of pathological_gambling . +AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD . +Mutations in the fukutin-related_protein -LRB- FKRP -RRB- gene cause limb-girdle_muscular_dystrophy type 2I -LRB- LGMD2I -RRB- as well as other severe muscle_disorders , including Walker-Warburg_syndrome , muscle-eye-brain_disease , and congenital_muscular_dystrophy type 1C . +AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD . +Based on its documented antifungal efficacy and an excellent safety profile , caspofungin has been approved recently by the US Food and Drug Administration for the treatment of invasive_aspergillosis in patients who are refractory to or intolerant of other therapies -LRB- i.e. , amphotericin_B , lipid formulations of amphotericin_B , and/or itraconazole -RRB- . +A phase 2 , randomized , double-blind , placebo-controlled , dose-ranging study to evaluate the efficacy and safety of orally administered VT-1161 in the treatment of recurrent vulvovaginal_candidiasis . +METHODS : Eleven SSc patients with PAH -LRB- SScPAH + -RRB- , 13 SSc patients without PAH -LRB- SScPAH - -RRB- and 10 healthy control subjects were included . +A comparative analysis of the early activation marker CD69 on peripheral blood mononuclear cells -LRB- PBMC -RRB- of patients with AE and healthy controls after in vitro culture with crude E. multilocularis antigen revealed that specific expression of CD69 was induced in CD4 -LRB- + -RRB- T lymphocytes as well as in CD8 -LRB- + -RRB- T lymphocytes . \ No newline at end of file