pmid
int64
19.9M
38M
pubdate
int64
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[ { "contexts": [ "Furthermore, the biochemical observations on the metabolism of structurally similar compounds, naphthalene and 2-naphthol, by similar but different sets of enzymes in strain BC1 were validated by real-time PCR analyses." ], "name": "THERM" } ]
24,088,780
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[]
24,947,785
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[ { "contexts": [ "Joint modeling of longitudinal and survival data with missing and left-censored time-varying covariates.We propose a joint model for longitudinal and survival data with time-varying covariates subject to detection limits and intermittent missingness at random. ", "The model is motivated by data from the Multicenter AIDS Cohort Study (MACS), in which HIV+ subjects have viral load and CD4 cell count measured at repeated visits along with survival data. ", "We model the longitudinal component using a normal linear mixed model, modeling the trajectory of CD4 cell count by regressing on viral load, and other covariates. ", "The viral load data are subject to both left censoring because of detection limits (17%) and intermittent missingness (27%). ", "The survival component of the joint model is a Cox model with time-dependent covariates for death because of AIDS. ", "The longitudinal and survival models are linked using the trajectory function of the linear mixed model. ", "A Bayesian analysis is conducted on the MACS data using the proposed joint model. ", "The proposed method is shown to improve the precision of estimates when compared with alternative methods." ], "name": "R" }, { "contexts": [ "Joint modeling of longitudinal and survival data with missing and left-censored time-varying covariates.We propose a joint model for longitudinal and survival data with time-varying covariates subject to detection limits and intermittent missingness at random. ", "The model is motivated by data from the Multicenter AIDS Cohort Study (MACS), in which HIV+ subjects have viral load and CD4 cell count measured at repeated visits along with survival data. ", "We model the longitudinal component using a normal linear mixed model, modeling the trajectory of CD4 cell count by regressing on viral load, and other covariates. ", "The viral load data are subject to both left censoring because of detection limits (17%) and intermittent missingness (27%). ", "The survival component of the joint model is a Cox model with time-dependent covariates for death because of AIDS. ", "The longitudinal and survival models are linked using the trajectory function of the linear mixed model. ", "A Bayesian analysis is conducted on the MACS data using the proposed joint model. ", "The proposed method is shown to improve the precision of estimates when compared with alternative methods." ], "name": "R" } ]
24,945,379
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[ { "contexts": [ "Furthermore, EGFL7-overexpressing cells grew into larger tumors and were more likely to metastasize to the liver compared to underexpressing CG cells following subcutaneous injection in mice. " ], "name": "THERM" } ]
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[]
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[]
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[ { "contexts": [ "Hundred children born moderately preterm were allocated in Group B and 100 term born children were recruited in Group A. Participants of both the groups were evaluated using the First STEP- screening test to evaluate preschoolers.\n\n\n" ], "name": "First STEP- screening test" }, { "contexts": [ "Hundred children born moderately preterm were allocated in Group B and 100 term born children were recruited in Group A. Participants of both the groups were evaluated using the First STEP- screening test to evaluate preschoolers.\n\n\n" ], "name": "the First STEP- screening test" } ]
24,512,053
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[]
25,086,372
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[]
25,362,943
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[]
24,755,345
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[]
25,215,980
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25,138,685
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[ { "contexts": [ "Medical history, lifestyle, family history, and occupational risk factors for follicular lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.BACKGROUND\n", "Follicular lymphoma (FL) has been linked with cigarette smoking and, inconsistently, with other risk factors.\n\n\n", "We assessed associations of medical, hormonal, family history, lifestyle, and occupational factors with FL risk in 3530 cases and 22639 controls from 19 case-control studies in the InterLymph consortium. ", "Age-, race/ethnicity-, sex- and study-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.\n\n\n", "Most risk factors that were evaluated showed no association, except for a few modest or sex-specific relationships. ", "FL risk was increased in persons: with a first-degree relative with non-Hodgkin lymphoma (OR = 1.99; 95% CI = 1.55 to 2.54); with greater body mass index as a young adult (OR = 1.15; 95% CI = 1.04 to 1.27 per 5 kg/m(2) increase); who worked as spray painters (OR = 2.66; 95% CI = 1.36 to 5.24); and among women with Sjögren syndrome (OR = 3.37; 95% CI = 1.23 to 9.19). ", "Lower FL risks were observed in persons: with asthma, hay fever, and food allergy (ORs = 0.79-0.85); blood transfusions (OR = 0.78; 95% CI = 0.68 to 0.89); high recreational sun exposure (OR = 0.74; 95% CI = 0.65 to 0.86, fourth vs first quartile); who worked as bakers or millers (OR = 0.51; 95% CI = 0.28 to 0.93) or university/higher education teachers (OR = 0.58; 95% CI = 0.41 to 0.83). ", "Elevated risks specific to women included current and longer duration of cigarette use, whereas reduced risks included current alcohol use, hay fever, and food allergies. ", "Other factors, including other autoimmune diseases, eczema, hepatitis C virus seropositivity, hormonal drugs, hair dye use, sun exposure, and farming, were not associated with FL risk.\n\n\n", "CONCLUSIONS\n", "The few relationships observed provide clues suggesting a multifactorial etiology of FL but are limited in the extent to which they explain FL occurrence." ], "name": "C" } ]
25,139,817
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24,838,560
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25,596,054
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[ { "contexts": [ "Intracranial internal carotid artery changes in acromegaly: a quantitative magnetic resonance angiography study.PURPOSE\n", "Although cerebrovascular mortality is increased up to eightfold in acromegaly, intracranial internal carotid artery (ICA) changes have not been well investigated. ", "This is a magnetic resonance angiography (MRA) quantitative cross-sectional study of ICA tortuosity, ectasia and intercarotid distance in acromegalic patients with subsequent analysis of concomitant clinical, laboratory and neuroimaging findings.\n\n\n", "One hundred seventy six acromegalic patients (mean-age 55 ± 14 years, age range 21-88, 92 females) and 104 subjects with headache or transient neurological deficits underwent MRA with the same 1.5 T scanner. ", "Clinical data, laboratory and pituitary adenoma imaging findings were recorded. ", "Using a commercially available software, we measured the tortuosity index [(curved/linear ICA length from C3-midpoint to intracranial bifurcation) - 1], ICA ectasia index (intracavernous/petrous ICA diameter) and intercarotid distance at C3 and C4 levels.\n\n\n", "Mean ICA tortuosity and ectasia indices were increased in acromegalic patients compared with controls (1.06 ± 0.29 vs 0.93 ± 0.26, p < 0.001; 1.02 ± 0.10 vs 0.92 ± 0.09, p < 0.001). ", "Mean intercarotid distance was reduced at C3 and increased at C4 in acromegalic patients (16.7 ± 3.4 vs 17.9 ± 2.5 mm, p < 0.001; 16.7 ± 4.6 vs 15.4 ± 4.1 mm, p < 0.05; t test). ", "ICA tortuosity and ectasia correlated neither with laboratory findings nor with previous or current treatment. ", "On multivariate analysis, C3 intercarotid distance was reduced in patients on dopamine agonist treatment (p < 0.01) and increased in patients with GH-deficit (p = 0.01), while C4 intercarotid distance was increased with macroadenoma (p = 0.01) and reduced in patients under dopamine agonist (p < 0.01) or somatostatin analogue (p < 0.05) treatment.\n\n\n", "CONCLUSIONS\n", "Intracranial ICA changes are common findings in acromegaly, and further studies focused on their possible clinical impact are needed." ], "name": "C" } ]
24,907,394
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24,862,449
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[]
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[]
25,139,745
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[]
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[]
24,381,356
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[ { "contexts": [ "Furthermore, the expression of genes that relate to aging, such as p53, p21 and Bax, was decreased, while that of Mdm2 and TERT genes was increased after treatment with LBPs. " ], "name": "THERM" } ]
24,946,778
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24,516,373
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25,249,926
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24,791,054
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[ { "contexts": [ "The analysis of the resulting inhibition slope was performed employing linear regression function included in Matlab. " ], "name": "Matlab" } ]
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[]
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[ { "contexts": [ "Our secondary outcomes contrasted total body weight by other measures of efficacy (numeric rating scale <3, pain relief, satisfaction, and desire for more analgesics) and adverse events (nausea, vomiting, and pruritus). " ], "name": "THERM" } ]
25,095,853
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[]
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[]
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[ { "contexts": [ "We use the Human Phenotype Ontology database to relate the phenotypes of 922 deletion cases recorded in the DECIPHER database to monogenic diseases associated with genes in or adjacent to the deletions. " ], "name": "DECIPHER" }, { "contexts": [ "We use the Human Phenotype Ontology database to relate the phenotypes of 922 deletion cases recorded in the DECIPHER database to monogenic diseases associated with genes in or adjacent to the deletions. " ], "name": "Human Phenotype Ontology database" } ]
25,009,509
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[ { "contexts": [ "How CAGE, RAPS4-QF, and AUDIT Can Help Practitioners for Patients Admitted with Acute Alcohol Intoxication in Emergency Departments?", "All patients admitted to the ED with AAI (blood alcohol level >0.8 g/L), in a 2-month period, were assessed using the CAGE, RAPS-QF, and AUDIT, with the alcohol dependence/abuse section of the mini international neuropsychiatric interview (MINI) used as the gold standard. ", "Different thresholds proposed for the CAGE, RAPS4-QF, and AUDIT could be used to guide the choice of intervention for a patient: brief intervention, brief negotiation interviewing, or longer more intensive motivational intervention." ], "name": "CAGE" }, { "contexts": [ "How CAGE, RAPS4-QF, and AUDIT Can Help Practitioners for Patients Admitted with Acute Alcohol Intoxication in Emergency Departments?", "Different thresholds proposed for the CAGE, RAPS4-QF, and AUDIT could be used to guide the choice of intervention for a patient: brief intervention, brief negotiation interviewing, or longer more intensive motivational intervention." ], "name": "RAPS4-QF" }, { "contexts": [ "How CAGE, RAPS4-QF, and AUDIT Can Help Practitioners for Patients Admitted with Acute Alcohol Intoxication in Emergency Departments?", "Especially, taking account of the high prevalence of alcohol dependence among patients admitted to the emergency department (ED) for acute alcohol intoxication (AAI), we propose to define thresholds of severity of dependence based on the AUDIT score.\n\n\n", "All patients admitted to the ED with AAI (blood alcohol level >0.8 g/L), in a 2-month period, were assessed using the CAGE, RAPS-QF, and AUDIT, with the alcohol dependence/abuse section of the mini international neuropsychiatric interview (MINI) used as the gold standard. ", "To explore the relation between the AUDIT and the MINI the sum of the positive items on the MINI (dependence) as a quantitative variable and as an ordinal parameter were analyzed. ", "Cut points were determined for the AUDIT in order to distinguish mild and moderate dependence from severe dependence. ", "Different thresholds proposed for the CAGE, RAPS4-QF, and AUDIT could be used to guide the choice of intervention for a patient: brief intervention, brief negotiation interviewing, or longer more intensive motivational intervention." ], "name": "AUDIT" } ]
24,482,544
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[ { "contexts": [ "Multimodality imaging consisting of thoracic radiographs, transthoracic and transesophageal echocardiography, fluoroscopy-guided selective angiography, computed tomography angiogram (CTA) and magnetic resonance angiogram (MRA), was performed on this patient. " ], "name": "transesophageal echocardiography" }, { "contexts": [ "Multimodality imaging consisting of thoracic radiographs, transthoracic and transesophageal echocardiography, fluoroscopy-guided selective angiography, computed tomography angiogram (CTA) and magnetic resonance angiogram (MRA), was performed on this patient. " ], "name": "fluoroscopy-guided selective angiography" }, { "contexts": [ "Multimodality imaging consisting of thoracic radiographs, transthoracic and transesophageal echocardiography, fluoroscopy-guided selective angiography, computed tomography angiogram (CTA) and magnetic resonance angiogram (MRA), was performed on this patient. " ], "name": "computed tomography angiogram (CTA)" }, { "contexts": [ "Multimodality imaging consisting of thoracic radiographs, transthoracic and transesophageal echocardiography, fluoroscopy-guided selective angiography, computed tomography angiogram (CTA) and magnetic resonance angiogram (MRA), was performed on this patient. " ], "name": "magnetic resonance angiogram (MRA)" } ]
24,556,276
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[]
25,988,059
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[]
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[ { "contexts": [ "A 55-year-old man underwent brain magnetic resonance imaging (MRI) for a medical check-up, and a suprasellar tumor was detected. ", "MRI detected a lobular tumor that was isointense on T1-weighted images, hypointense on T2-weighted images, and showed homogeneous enhancement after administration of a gadopentetate dimeglumine. ", "Postoperative MRI showed that the tumor volume was reduced and optic tract edema diminished compared with the preoperative findings. ", "We also review the literature focusing on radiographic findings, and compare the effectiveness of MRI and CT for diagnosing granular cell tumor of the neurohypophysis." ], "name": "MRI" }, { "contexts": [ "Granular cell tumor of the neurohypophysis with optic tract edema.Granular cell tumor of the neurohypophysis is a rare disease entity. ", "To our knowledge, this is the first report concerning a granular cell tumor of the neurohypophysis associated with optic tract edema. ", "A 55-year-old man underwent brain magnetic resonance imaging (MRI) for a medical check-up, and a suprasellar tumor was detected. ", "Brain computed tomography (CT) demonstrated a well delineated, homogenous, slightly hyperdense suprasellar tumor. ", "MRI detected a lobular tumor that was isointense on T1-weighted images, hypointense on T2-weighted images, and showed homogeneous enhancement after administration of a gadopentetate dimeglumine. ", "T2-weighted images and fluid-attenuated inversion recovery (FLAIR) images demonstrated a hyperintense region in the optic tract. ", "Subtotal tumor resection was performed, and histological examination confirmed the diagnosis of granular cell tumor. ", "Postoperative MRI showed that the tumor volume was reduced and optic tract edema diminished compared with the preoperative findings. ", "We also review the literature focusing on radiographic findings, and compare the effectiveness of MRI and CT for diagnosing granular cell tumor of the neurohypophysis." ], "name": "CT" }, { "contexts": [ "T2-weighted images and fluid-attenuated inversion recovery (FLAIR) images demonstrated a hyperintense region in the optic tract. " ], "name": "FLAIR" } ]
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[ { "contexts": [ "Firstly, the ultrastructural morphology of a healthy female's erythrocytes was examined via scanning electron microscopy (SEM) after exposure to the newly in silico-designed compounds. " ], "name": "scanning electron microscopy (SEM)" }, { "contexts": [ "The haemolytic activity of the compounds after 24 hours exposure were also determined with the ex vivo haemolysis assay. " ], "name": "ex vivo haemolysis assay" } ]
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[ { "contexts": [ "Furthermore, it highlights the transcription factor RXRγ as a new player in BAT development." ], "name": "THERM" } ]
24,146,070
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[ { "contexts": [ "Evaluation of the MALDI-TOF VITEK MS™ system for the identification of Candida parapsilosis, C. orthopsilosis and C. metapsilosis from bloodstream infections.Twenty-nine Candida parapsilosis, seventeen Candida orthopsilosis and two Candida metapsilosis bloodstream isolates were submitted for identification by VITEK-MS™ mass spectrometer. " ], "name": "VITEK MS" }, { "contexts": [ "Evaluation of the MALDI-TOF VITEK MS™ system for the identification of Candida parapsilosis, C. orthopsilosis and C. metapsilosis from bloodstream infections.Twenty-nine Candida parapsilosis, seventeen Candida orthopsilosis and two Candida metapsilosis bloodstream isolates were submitted for identification by VITEK-MS™ mass spectrometer. " ], "name": "MALDI-TOF VITEK MS" } ]