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JerrySiRi

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SWN_Bert_based_2014_2018_15000

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[ { "contexts": [ "The relative distribution and overall density of the lysosomal leaks dictated whether microdomains triggered or modulated global signals. " ], "name": "THERM" } ]

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[ { "contexts": [ "Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.SHIP2, OCRL, and INPP5B belong to inositol polyphosphate 5-phophatase subfamilies involved in insulin regulation and Lowes syndrome. ", "We determined the crystal structures of human SHIP2, OCRL, and INPP5B, the latter in complex with phosphoinositide substrate analogs, which revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer. " ], "name": "SHIP2" }, { "contexts": [ "Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.SHIP2, OCRL, and INPP5B belong to inositol polyphosphate 5-phophatase subfamilies involved in insulin regulation and Lowes syndrome. ", "We determined the crystal structures of human SHIP2, OCRL, and INPP5B, the latter in complex with phosphoinositide substrate analogs, which revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer. " ], "name": "OCRL" }, { "contexts": [ "Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.SHIP2, OCRL, and INPP5B belong to inositol polyphosphate 5-phophatase subfamilies involved in insulin regulation and Lowes syndrome. ", "We determined the crystal structures of human SHIP2, OCRL, and INPP5B, the latter in complex with phosphoinositide substrate analogs, which revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer. " ], "name": "INPP5B" } ]

[ { "contexts": [ "Furthermore, the benefits are determined by both the interacting partner's performance and similarity of the partner's behavior to one's own. " ], "name": "THERM" } ]

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[ { "contexts": [ "Using proprietary software, digital images can also be annotated with arrows, circles and boxes to highlight certain diagnostic features. " ], "name": "proprietary software" }, { "contexts": [ "Using proprietary software, digital images can also be annotated with arrows, circles and boxes to highlight certain diagnostic features. ", "Previous studies assessing digital microscopy as a teaching tool did not involve the annotation of digital images. " ], "name": "digital images" } ]

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[ { "contexts": [ "For this purpose, a four-color, multi-region, micro-lensed spinning disk confocal microscope that allows long-term continuous imaging with rapid image acquisition has been used. " ], "name": "spinning disk confocal microscope" }, { "contexts": [ "A surgical procedure described here allows direct observation of myeloid cell dynamics within the intestinal tumors in live mice by using transgenic fluorescent reporter mice and injectable tracers or antibodies. " ], "name": "transgenic fluorescent reporter mice" }, { "contexts": [ "A surgical procedure described here allows direct observation of myeloid cell dynamics within the intestinal tumors in live mice by using transgenic fluorescent reporter mice and injectable tracers or antibodies. " ], "name": "injectable tracers or antibodies" } ]

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[ { "contexts": [ "ROS1 mutation and treatment with crizotinib in a 30-year old Caucasian woman with stage IV non-small cell lung cancer/adenocarcinoma and complete remission.In this case report we describe a 30 year-old Caucasian woman with a histopathological diagnosis of pulmonary adenocarcinoma in both lungs with lipidic and micropapillary growth pattern and ROS1 (C-ros oncogene 1, receptor tyrosine kinase) rearrangement. ", "There is evidence that crizotinib can be used for molecular target therapy in these patients. ", "We enrolled the patient in an off-label program for the treatment of ROS1 rearranged adenocarcinomas with the EML4/anaplastic lymphoma kinase inhibitor crizotinib. " ], "name": "crizotinib" }, { "contexts": [ "ROS1 mutation and treatment with crizotinib in a 30-year old Caucasian woman with stage IV non-small cell lung cancer/adenocarcinoma and complete remission.In this case report we describe a 30 year-old Caucasian woman with a histopathological diagnosis of pulmonary adenocarcinoma in both lungs with lipidic and micropapillary growth pattern and ROS1 (C-ros oncogene 1, receptor tyrosine kinase) rearrangement. ", "There is evidence that crizotinib can be used for molecular target therapy in these patients. ", "We enrolled the patient in an off-label program for the treatment of ROS1 rearranged adenocarcinomas with the EML4/anaplastic lymphoma kinase inhibitor crizotinib. " ], "name": "crizotinib" }, { "contexts": [ "ROS1 mutation and treatment with crizotinib in a 30-year old Caucasian woman with stage IV non-small cell lung cancer/adenocarcinoma and complete remission.In this case report we describe a 30 year-old Caucasian woman with a histopathological diagnosis of pulmonary adenocarcinoma in both lungs with lipidic and micropapillary growth pattern and ROS1 (C-ros oncogene 1, receptor tyrosine kinase) rearrangement. ", "There is evidence that crizotinib can be used for molecular target therapy in these patients. ", "We enrolled the patient in an off-label program for the treatment of ROS1 rearranged adenocarcinomas with the EML4/anaplastic lymphoma kinase inhibitor crizotinib. " ], "name": "crizotinib" }, { "contexts": [ "ROS1 mutation and treatment with crizotinib in a 30-year old Caucasian woman with stage IV non-small cell lung cancer/adenocarcinoma and complete remission.In this case report we describe a 30 year-old Caucasian woman with a histopathological diagnosis of pulmonary adenocarcinoma in both lungs with lipidic and micropapillary growth pattern and ROS1 (C-ros oncogene 1, receptor tyrosine kinase) rearrangement. ", "There is evidence that crizotinib can be used for molecular target therapy in these patients. ", "We enrolled the patient in an off-label program for the treatment of ROS1 rearranged adenocarcinomas with the EML4/anaplastic lymphoma kinase inhibitor crizotinib. " ], "name": "crizotinib" }, { "contexts": [ "ROS1 mutation and treatment with crizotinib in a 30-year old Caucasian woman with stage IV non-small cell lung cancer/adenocarcinoma and complete remission.In this case report we describe a 30 year-old Caucasian woman with a histopathological diagnosis of pulmonary adenocarcinoma in both lungs with lipidic and micropapillary growth pattern and ROS1 (C-ros oncogene 1, receptor tyrosine kinase) rearrangement. ", "There is evidence that crizotinib can be used for molecular target therapy in these patients. ", "We enrolled the patient in an off-label program for the treatment of ROS1 rearranged adenocarcinomas with the EML4/anaplastic lymphoma kinase inhibitor crizotinib. " ], "name": "crizotinib" } ]

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[ { "contexts": [ "When absorbed light is in excess, the thermal dissipation systems of excess energy are induced and the photosynthetic electron flow is regulated, both contributing to suppression of reactive oxygen species production and photodamages. " ], "name": "THERM" } ]

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[ { "contexts": [ "The morphologic features raised the suspicion for partial hydatidiform mole, and DNA genotyping was performed using the AmpFlSTR Identifiler PCR Amplification system. " ], "name": "AmpFlSTR Identifiler PCR Amplification system" } ]

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[ { "contexts": [ "Furthermore, HCV+MC patients with autoimmune thyroiditis (AT), have higher levels than those without AT. " ], "name": "THERM" } ]

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[ { "contexts": [ "Furthermore, we found that the multidrug resistant phenotype of 253J/DOX cells could be overcome by sinomenine, an alkaloid derived from the stem of Sinomenium acutum. " ], "name": "THERM" } ]

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[ { "contexts": [ "Capillary blood glucose readings of 3.9 mmol/L or less (hypoglycaemia) for all adult (≥18 years) inpatients with diabetes 'at risk' of hypoglycaemia were extracted from the Abbott PrecisionWeb Point-of-Care Data Management System over a 4-week period. " ], "name": "PrecisionWeb Point-of-Care Data Management System" } ]

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[ { "contexts": [ "Laboratory drop towers for the experimental simulation of dust-aggregate collisions in the early solar system.For the purpose of investigating the evolution of dust aggregates in the early Solar System, we developed two vacuum drop towers in which fragile dust aggregates with sizes up to ~10 cm and porosities up to 70% can be collided. ", "One of the drop towers is primarily used for very low impact speeds down to below 0.01 m/sec and makes use of a double release mechanism. ", "In both drop towers, the dust aggregates are in free fall during the collision so that they are weightless and match the conditions in the early Solar System." ], "name": "drop towers" }, { "contexts": [ "Collisions are recorded in stereo-view by two high-speed cameras, which fall along the glass vacuum tube in the center-of-mass frame of the two dust aggregates. ", "Here, two fixed high-speed cameras record the collision events. " ], "name": "high-speed cameras" }, { "contexts": [ "The other free-fall tower makes use of an electromagnetic accelerator that is capable of gently accelerating dust aggregates to up to 5 m/sec. " ], "name": "electromagnetic accelerator" } ]

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[ { "contexts": [ "Furthermore, increased syndecan-2 shedding was dependent on the mitogen-activated protein kinase-mediated MMP-7 expression. " ], "name": "THERM" } ]

[ { "contexts": [ "Furthermore, deprotonation of the amidinium chitin and re-protonation of the resulting amidinated chitin were conducted by alkaline treatment and CO2 gas bubbling-ultrasonic treatments, respectively. " ], "name": "THERM" } ]

[ { "contexts": [ "Laser interstitial thermal therapy in treatment of brain tumors--the NeuroBlate System.Treatment of brain tumors remains challenging. ", "Laser interstitial thermal therapy (LITT) is a minimally invasive cytoreductive treatment. ", "A low voltage laser is used to induce hyperthermia and to kill tumor cells. ", "The extent of thermal damage is controlled through use of real-time MR-thermography guidance. " ], "name": "THERM" } ]

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[ { "contexts": [ "The synthesized polymer electrolyte membranes showed better thermal and dimensional stabilities owing to the inducted highly conjugated aromatic structure in the polymer backbone. " ], "name": "THERM" } ]

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[ { "contexts": [ "Clinical as well as histological data were analysed and frequency of each type of OT was calculated using computer software programme SPSS (version 17). " ], "name": "SPSS" } ]

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[ { "contexts": [ "Furthermore, the means were not in the expected direction, as children with NVLD actually performed faster than typically developing children. " ], "name": "THERM" } ]

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[ { "contexts": [ "The attention training technique, self-focused attention, and anxiety: a laboratory-based component study.Self-focused attention is an important target of intervention within Wells's (2009) metacognitive therapy and the attention training technique (ATT) is one component of metacognitive therapy that purportedly alters focus of attention. ", "However, we do not yet fully understand whether ATT causes changes in focus of attention, the effectiveness of ATT compared to other techniques in reducing self-focused attention, and how ATT leads to its therapeutic gains. ", "Nonclinical participants were randomly assigned to one session of ATT (n = 38) or a mindfulness-based task (n = 38). ", "ATT and the mindfulness-based task differentially changed focus of attention, with ATT causing greater external focus of attention and the mindfulness-based task causing greater self-focused attention from pre-to-post manipulation. ", "ATT and the mindfulness-based task both led to reductions in anxiety. ", "Reductions in self-focused attention were related to less anxiety following ATT, whereas increases in self-focused attention were related to less anxiety following the mindfulness-based task. " ], "name": "ATT" }, { "contexts": [ "The attention training technique, self-focused attention, and anxiety: a laboratory-based component study.Self-focused attention is an important target of intervention within Wells's (2009) metacognitive therapy and the attention training technique (ATT) is one component of metacognitive therapy that purportedly alters focus of attention. " ], "name": "The ATT" }, { "contexts": [ "The attention training technique, self-focused attention, and anxiety: a laboratory-based component study.Self-focused attention is an important target of intervention within Wells's (2009) metacognitive therapy and the attention training technique (ATT) is one component of metacognitive therapy that purportedly alters focus of attention. " ], "name": "metacognitive therapy" }, { "contexts": [ "The attention training technique, self-focused attention, and anxiety: a laboratory-based component study.Self-focused attention is an important target of intervention within Wells's (2009) metacognitive therapy and the attention training technique (ATT) is one component of metacognitive therapy that purportedly alters focus of attention. ", "However, we do not yet fully understand whether ATT causes changes in focus of attention, the effectiveness of ATT compared to other techniques in reducing self-focused attention, and how ATT leads to its therapeutic gains. ", "Nonclinical participants were randomly assigned to one session of ATT (n = 38) or a mindfulness-based task (n = 38). ", "ATT and the mindfulness-based task differentially changed focus of attention, with ATT causing greater external focus of attention and the mindfulness-based task causing greater self-focused attention from pre-to-post manipulation. ", "ATT and the mindfulness-based task both led to reductions in anxiety. ", "Reductions in self-focused attention were related to less anxiety following ATT, whereas increases in self-focused attention were related to less anxiety following the mindfulness-based task. " ], "name": "ATT" }, { "contexts": [ "The attention training technique, self-focused attention, and anxiety: a laboratory-based component study.Self-focused attention is an important target of intervention within Wells's (2009) metacognitive therapy and the attention training technique (ATT) is one component of metacognitive therapy that purportedly alters focus of attention. " ], "name": "metacognitive therapy" }, { "contexts": [ "The attention training technique, self-focused attention, and anxiety: a laboratory-based component study.Self-focused attention is an important target of intervention within Wells's (2009) metacognitive therapy and the attention training technique (ATT) is one component of metacognitive therapy that purportedly alters focus of attention. ", "However, we do not yet fully understand whether ATT causes changes in focus of attention, the effectiveness of ATT compared to other techniques in reducing self-focused attention, and how ATT leads to its therapeutic gains. ", "Nonclinical participants were randomly assigned to one session of ATT (n = 38) or a mindfulness-based task (n = 38). ", "ATT and the mindfulness-based task differentially changed focus of attention, with ATT causing greater external focus of attention and the mindfulness-based task causing greater self-focused attention from pre-to-post manipulation. ", "ATT and the mindfulness-based task both led to reductions in anxiety. ", "Reductions in self-focused attention were related to less anxiety following ATT, whereas increases in self-focused attention were related to less anxiety following the mindfulness-based task. " ], "name": "ATT" } ]

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[ { "contexts": [ "Photodecarbonylation mechanism of cyclopropenone in the gas phase: electronic structure calculation and AIMS dynamics simulation.In this article, structures and energies of cyclopropenone in the low-lying electronic states have been determined by the CASSCF and MS-CASPT2 calculations with different basis sets. " ], "name": "CASSCF" }, { "contexts": [ "Photodecarbonylation mechanism of cyclopropenone in the gas phase: electronic structure calculation and AIMS dynamics simulation.In this article, structures and energies of cyclopropenone in the low-lying electronic states have been determined by the CASSCF and MS-CASPT2 calculations with different basis sets. " ], "name": "MS-CASPT2" }, { "contexts": [ "Two minimum-energy conical intersections (CI-1 and CI-2) between S0 and S1 were obtained and their topographic characters were characterized by the SA4-CAS(10,9) calculated energy gradients and nonadiabatic coupling vectors. ", "The AIMS method was used to carry out nonadiabatic dynamics simulation with ab initio calculation performed at the SA4-CAS(10,9) level. " ], "name": "SA4-CAS(10,9)" }, { "contexts": [ "Photodecarbonylation mechanism of cyclopropenone in the gas phase: electronic structure calculation and AIMS dynamics simulation.In this article, structures and energies of cyclopropenone in the low-lying electronic states have been determined by the CASSCF and MS-CASPT2 calculations with different basis sets. ", "The AIMS method was used to carry out nonadiabatic dynamics simulation with ab initio calculation performed at the SA4-CAS(10,9) level. ", "The present study provides new insights into mechanistic photochemistry of cyclopropenones and reveals that the AIMS dynamics simulation at a high-accuracy ab initio level is a powerful tool for exploring a mechanism of an ultrafast photochemical reaction." ], "name": "AIMS" } ]

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[ { "contexts": [ "Furthermore, IRES-mediated translation was found to be significantly high in the presence of recombinant human La protein in vitro in rabbit reticulocyte lysate. " ], "name": "THERM" } ]

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