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stringlengths 15
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list | coreferences
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|---|---|---|---|---|---|---|
split_0_train_30500 | split_0_train_30500 | [
{
"id": "split_0_train_30500_passage",
"type": "progene_text",
"text": [
"In addition , type I IFNs ( alpha , beta ) have the capacity to inhibit HIV - 1 replication in polarized Th2 cells ."
],
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116
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}
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{
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"text": [
"type I IFNs ( alpha , beta )"
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14,
42
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30501 | split_0_train_30501 | [
{
"id": "split_0_train_30501_passage",
"type": "progene_text",
"text": [
"Type I IFNs reactivate the patients ' Th1 cells to synthesize IL-2 and IL - 12 cytokines , activators of the precursor cytotoxic T cells ( CTLs ) , leading to the reactivation of the inhibited adaptive immune response ."
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0,
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{
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"Type I IFNs"
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"IL-2"
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62,
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{
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"type": "progene_text",
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"IL - 12"
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71,
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{
"id": "split_0_train_49450_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
79,
88
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30502 | split_0_train_30502 | [
{
"id": "split_0_train_30502_passage",
"type": "progene_text",
"text": [
"Antiviral CTLs have the ability to clear the virus infection.The present novel approach to the treatment and of HIV-1 / AIDS patients with CpG ODNs may prevent HIV-1 transmission and the AIDS pandemic if controlled studies on the treatments with CpG ODNs of HIV-1 infected people will be done by international and private agencies and companies to define the effective treatment regime and the efficacy of the treatments to HIV-1 infected people at different times post - infection ."
],
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0,
483
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]
}
] | [] | [] | [] | [] |
split_0_train_30503 | split_0_train_30503 | [
{
"id": "split_0_train_30503_passage",
"type": "progene_text",
"text": [
"It is also hypothesized that in order to stop HIV-1 transmission in HIV-1 endemic regions the people at high risk of HIV-1 infection should be treated at the same time as HIV-1 infected people with a vaccine containing synthetic CpG - ODNs combined with synthetic HIV-1 peptides , compatible with the major HLA haplotypes of the regional population ."
],
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0,
350
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}
] | [
{
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"type": "progene_text",
"text": [
"HLA"
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307,
310
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30504 | split_0_train_30504 | [
{
"id": "split_0_train_30504_passage",
"type": "progene_text",
"text": [
"The vaccine may be self - applied by people at high risk of infection by the intra - nasal route and by intra - dermal application as a \" peplotion vaccine \" ."
],
"offsets": [
[
0,
159
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]
}
] | [] | [] | [] | [] |
split_0_train_30505 | split_0_train_30505 | [
{
"id": "split_0_train_30505_passage",
"type": "progene_text",
"text": [
"The stimulation of the antiviral CTL response by HIV-1 infected people and the active antiviral immune response in the vaccinated population may lead to a decline in HIV-1 transmission and may be a model for control of the HIV-1 / AIDS pandemic ."
],
"offsets": [
[
0,
246
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]
}
] | [] | [] | [] | [] |
split_0_train_30506 | split_0_train_30506 | [
{
"id": "split_0_train_30506_passage",
"type": "progene_text",
"text": [
"Cutting edge : KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein ."
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"offsets": [
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0,
118
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]
}
] | [
{
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"type": "progene_text",
"text": [
"KIR2DL4"
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15,
22
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{
"id": "split_0_train_49453_entity",
"type": "progene_text",
"text": [
"Fc receptor gamma"
],
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[
91,
108
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30507 | split_0_train_30507 | [
{
"id": "split_0_train_30507_passage",
"type": "progene_text",
"text": [
"KIR2DL4 ( 2DL4 , CD158d ) , a member of the human killer cell Ig - like receptor ( KIR ) family , triggers potent IFN-gamma responses but weak cytotoxicity in resting NK cells ."
],
"offsets": [
[
0,
177
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}
] | [
{
"id": "split_0_train_49454_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
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7
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{
"id": "split_0_train_49455_entity",
"type": "progene_text",
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"2DL4"
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10,
14
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{
"id": "split_0_train_49456_entity",
"type": "progene_text",
"text": [
"CD158d"
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17,
23
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},
{
"id": "split_0_train_49457_entity",
"type": "progene_text",
"text": [
"killer cell Ig - like receptor ( KIR ) family"
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50,
95
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},
{
"id": "split_0_train_49458_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
114,
123
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30508 | split_0_train_30508 | [
{
"id": "split_0_train_30508_passage",
"type": "progene_text",
"text": [
"2DL4 mRNA has been detected in most NK cell clones from most humans examined , but surface protein expression is detectable only on CD56 ( high ) NK cells from certain donors ."
],
"offsets": [
[
0,
176
]
]
}
] | [
{
"id": "split_0_train_49459_entity",
"type": "progene_text",
"text": [
"2DL4"
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"offsets": [
[
0,
4
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"normalized": []
},
{
"id": "split_0_train_49460_entity",
"type": "progene_text",
"text": [
"CD56"
],
"offsets": [
[
132,
136
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30509 | split_0_train_30509 | [
{
"id": "split_0_train_30509_passage",
"type": "progene_text",
"text": [
"The receptor possesses a transmembrane arginine residue , suggesting association with a signaling accessory protein that has remained elusive ."
],
"offsets": [
[
0,
143
]
]
}
] | [] | [] | [] | [] |
split_0_train_30510 | split_0_train_30510 | [
{
"id": "split_0_train_30510_passage",
"type": "progene_text",
"text": [
"We provide biochemical and functional evidence that FcepsilonRI-gamma ( gamma ) associates with 2DL4 to promote surface expression and provide signal transducing function ."
],
"offsets": [
[
0,
172
]
]
}
] | [
{
"id": "split_0_train_49461_entity",
"type": "progene_text",
"text": [
"FcepsilonRI-gamma"
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"offsets": [
[
52,
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"normalized": []
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{
"id": "split_0_train_49462_entity",
"type": "progene_text",
"text": [
"2DL4"
],
"offsets": [
[
96,
100
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30511 | split_0_train_30511 | [
{
"id": "split_0_train_30511_passage",
"type": "progene_text",
"text": [
"Weak cytolytic responses triggered through 2DL4 may result from low stoichiometric association with gamma ."
],
"offsets": [
[
0,
107
]
]
}
] | [
{
"id": "split_0_train_49463_entity",
"type": "progene_text",
"text": [
"2DL4"
],
"offsets": [
[
43,
47
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30512 | split_0_train_30512 | [
{
"id": "split_0_train_30512_passage",
"type": "progene_text",
"text": [
"Selective association with gamma distinguishes 2DL4 from all other activating forms of the KIR family , which alternatively associate with DNAX - activating protein ( DAP ) 12 ."
],
"offsets": [
[
0,
177
]
]
}
] | [
{
"id": "split_0_train_49464_entity",
"type": "progene_text",
"text": [
"2DL4"
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"offsets": [
[
47,
51
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],
"normalized": []
},
{
"id": "split_0_train_49465_entity",
"type": "progene_text",
"text": [
"KIR family"
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[
91,
101
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],
"normalized": []
},
{
"id": "split_0_train_49466_entity",
"type": "progene_text",
"text": [
"DNAX - activating protein ( DAP ) 12"
],
"offsets": [
[
139,
175
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30513 | split_0_train_30513 | [
{
"id": "split_0_train_30513_passage",
"type": "progene_text",
"text": [
"Association of nucleotide variations in the apolipoprotein B48 receptor gene ( APOB48R ) with hypercholesterolemia ."
],
"offsets": [
[
0,
116
]
]
}
] | [
{
"id": "split_0_train_49467_entity",
"type": "progene_text",
"text": [
"apolipoprotein B48 receptor"
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"offsets": [
[
44,
71
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],
"normalized": []
},
{
"id": "split_0_train_49468_entity",
"type": "progene_text",
"text": [
"APOB48R"
],
"offsets": [
[
79,
86
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30514 | split_0_train_30514 | [
{
"id": "split_0_train_30514_passage",
"type": "progene_text",
"text": [
"Factors predisposing to the phenotypic features of high total cholesterol ( T-Cho ) in human plasma have not been clearly defined ."
],
"offsets": [
[
0,
131
]
]
}
] | [] | [] | [] | [] |
split_0_train_30515 | split_0_train_30515 | [
{
"id": "split_0_train_30515_passage",
"type": "progene_text",
"text": [
"Here we report an association between two variations in the apolipoprotein B48 receptor gene ( APOB48R ) and plasma T-Cho levels among 352 adult individuals in Japan ."
],
"offsets": [
[
0,
167
]
]
}
] | [
{
"id": "split_0_train_49469_entity",
"type": "progene_text",
"text": [
"apolipoprotein B48 receptor"
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[
60,
87
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],
"normalized": []
},
{
"id": "split_0_train_49470_entity",
"type": "progene_text",
"text": [
"APOB48R"
],
"offsets": [
[
95,
102
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30516 | split_0_train_30516 | [
{
"id": "split_0_train_30516_passage",
"type": "progene_text",
"text": [
"By analyzing phenotypic associations between age - and gender - adjusted levels of plasma T-Cho , low - density lipoprotein ( LDL ) cholesterol ( LDL - C ) , and high - density lipoprotein ( HDL ) cholesterol ( HDL - C ) , we detected a significant correlation between genotypes of the A419P variation and adjusted T-Cho levels ."
],
"offsets": [
[
0,
329
]
]
}
] | [
{
"id": "split_0_train_49471_entity",
"type": "progene_text",
"text": [
"low - density lipoprotein"
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[
98,
123
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},
{
"id": "split_0_train_49472_entity",
"type": "progene_text",
"text": [
"LDL"
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"offsets": [
[
126,
129
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],
"normalized": []
},
{
"id": "split_0_train_49473_entity",
"type": "progene_text",
"text": [
"LDL"
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"offsets": [
[
146,
149
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],
"normalized": []
},
{
"id": "split_0_train_49474_entity",
"type": "progene_text",
"text": [
"high - density lipoprotein"
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[
162,
188
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{
"id": "split_0_train_49475_entity",
"type": "progene_text",
"text": [
"HDL"
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"offsets": [
[
191,
194
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],
"normalized": []
},
{
"id": "split_0_train_49476_entity",
"type": "progene_text",
"text": [
"HDL"
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"offsets": [
[
211,
214
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30517 | split_0_train_30517 | [
{
"id": "split_0_train_30517_passage",
"type": "progene_text",
"text": [
"Among homozygous G - allele carriers ( n = 265 ) , heterozygous carriers ( n = 78 ) , and homozygous minor C - allele carriers ( n = 9 ) , T-Cho levels were 2.43 +/- 0.21 mg / cm ( 3 ) , 2.48 + / - 0.24 mg / cm(3) , and 2.63 +/- 0.21 mg / cm(3) , respectively , indicating a codominant T-Cho-elevating effect of the minor C-allele ( r = 0.15 , P = 0.007 ) ."
],
"offsets": [
[
0,
357
]
]
}
] | [] | [] | [] | [] |
split_0_train_30518 | split_0_train_30518 | [
{
"id": "split_0_train_30518_passage",
"type": "progene_text",
"text": [
"A similar effect was detected for c.934 - 960 / del ( r = 0.13 , P = 0.015 ) ."
],
"offsets": [
[
0,
78
]
]
}
] | [] | [] | [] | [] |
split_0_train_30519 | split_0_train_30519 | [
{
"id": "split_0_train_30519_passage",
"type": "progene_text",
"text": [
"Linkage disequilibrium ( LD ) analysis detected significant LD among eight variant sites that included neighboring loci ."
],
"offsets": [
[
0,
121
]
]
}
] | [] | [] | [] | [] |
split_0_train_30520 | split_0_train_30520 | [
{
"id": "split_0_train_30520_passage",
"type": "progene_text",
"text": [
"Our results indicate that variations in APOB48R and nearby genes are among the many factors involved in hypercholesterolemia ."
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "split_0_train_49477_entity",
"type": "progene_text",
"text": [
"APOB48R"
],
"offsets": [
[
40,
47
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30521 | split_0_train_30521 | [
{
"id": "split_0_train_30521_passage",
"type": "progene_text",
"text": [
"The etiological studies should now include consideration of this novel aspect of the mechanism(s) leading to hypercholesterolemic disease ."
],
"offsets": [
[
0,
139
]
]
}
] | [] | [] | [] | [] |
split_0_train_30522 | split_0_train_30522 | [
{
"id": "split_0_train_30522_passage",
"type": "progene_text",
"text": [
"IL-6 transsignaling : the in vivo consequences ."
],
"offsets": [
[
0,
48
]
]
}
] | [
{
"id": "split_0_train_49478_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30523 | split_0_train_30523 | [
{
"id": "split_0_train_30523_passage",
"type": "progene_text",
"text": [
"Cytokine receptors exist in membrane - bound and soluble forms ."
],
"offsets": [
[
0,
64
]
]
}
] | [
{
"id": "split_0_train_49479_entity",
"type": "progene_text",
"text": [
"Cytokine receptors"
],
"offsets": [
[
0,
18
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30524 | split_0_train_30524 | [
{
"id": "split_0_train_30524_passage",
"type": "progene_text",
"text": [
"They bind their ligands with comparable affinity ."
],
"offsets": [
[
0,
50
]
]
}
] | [] | [] | [] | [] |
split_0_train_30525 | split_0_train_30525 | [
{
"id": "split_0_train_30525_passage",
"type": "progene_text",
"text": [
"Although most soluble receptors are antagonists because they compete with their membrane counterparts for their ligands , some soluble receptors are agonists ."
],
"offsets": [
[
0,
159
]
]
}
] | [] | [] | [] | [] |
split_0_train_30526 | split_0_train_30526 | [
{
"id": "split_0_train_30526_passage",
"type": "progene_text",
"text": [
"In this case , on target cells , the complex of cytokine and soluble cytokine receptor binds to a second receptor subunit and initiates intracellular signal transduction ."
],
"offsets": [
[
0,
171
]
]
}
] | [
{
"id": "split_0_train_49480_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
48,
56
]
],
"normalized": []
},
{
"id": "split_0_train_49481_entity",
"type": "progene_text",
"text": [
"cytokine receptor"
],
"offsets": [
[
69,
86
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30527 | split_0_train_30527 | [
{
"id": "split_0_train_30527_passage",
"type": "progene_text",
"text": [
"The soluble receptors of the interleukin-6 ( IL-6 ) family of cytokines -- soluble IL-6 receptor ( sIL-6R ) , sIL-11R , and soluble ciliary neurotrophic factor receptor ( sCNTFR ) -- are agonists ."
],
"offsets": [
[
0,
197
]
]
}
] | [
{
"id": "split_0_train_49482_entity",
"type": "progene_text",
"text": [
"interleukin-6 ( IL-6 ) family of cytokines"
],
"offsets": [
[
29,
71
]
],
"normalized": []
},
{
"id": "split_0_train_49483_entity",
"type": "progene_text",
"text": [
"IL-6 receptor"
],
"offsets": [
[
83,
96
]
],
"normalized": []
},
{
"id": "split_0_train_49484_entity",
"type": "progene_text",
"text": [
"sIL-6R"
],
"offsets": [
[
99,
105
]
],
"normalized": []
},
{
"id": "split_0_train_49485_entity",
"type": "progene_text",
"text": [
"sIL-11R"
],
"offsets": [
[
110,
117
]
],
"normalized": []
},
{
"id": "split_0_train_49486_entity",
"type": "progene_text",
"text": [
"ciliary neurotrophic factor receptor"
],
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[
132,
168
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],
"normalized": []
},
{
"id": "split_0_train_49487_entity",
"type": "progene_text",
"text": [
"sCNTFR"
],
"offsets": [
[
171,
177
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30528 | split_0_train_30528 | [
{
"id": "split_0_train_30528_passage",
"type": "progene_text",
"text": [
"In vivo , the IL-6 / sIL-6R complex stimulates several types of target cells not stimulated by IL-6 alone , as they do not express the membrane - bound IL-6R ."
],
"offsets": [
[
0,
159
]
]
}
] | [
{
"id": "split_0_train_49488_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_49489_entity",
"type": "progene_text",
"text": [
"sIL-6R"
],
"offsets": [
[
21,
27
]
],
"normalized": []
},
{
"id": "split_0_train_49490_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
95,
99
]
],
"normalized": []
},
{
"id": "split_0_train_49491_entity",
"type": "progene_text",
"text": [
"IL-6R"
],
"offsets": [
[
152,
157
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30529 | split_0_train_30529 | [
{
"id": "split_0_train_30529_passage",
"type": "progene_text",
"text": [
"This process has been named transsignaling ."
],
"offsets": [
[
0,
44
]
]
}
] | [] | [] | [] | [] |
split_0_train_30530 | split_0_train_30530 | [
{
"id": "split_0_train_30530_passage",
"type": "progene_text",
"text": [
"We have shown recently that in several chronic inflammatory diseases , such as chronic inflammatory bowl disease , peritonitis , and rheumatoid arthritis , as well as in colon cancer , transsignaling via the sIL-6R complexed to IL-6 is a crucial point in the maintenance of the disease ."
],
"offsets": [
[
0,
287
]
]
}
] | [
{
"id": "split_0_train_49492_entity",
"type": "progene_text",
"text": [
"sIL-6R"
],
"offsets": [
[
208,
214
]
],
"normalized": []
},
{
"id": "split_0_train_49493_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
228,
232
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30531 | split_0_train_30531 | [
{
"id": "split_0_train_30531_passage",
"type": "progene_text",
"text": [
"The mechanism by which the IL-6 / sIL-6R complex regulates the inflammatory or neoplastic state is discussed ."
],
"offsets": [
[
0,
110
]
]
}
] | [
{
"id": "split_0_train_49494_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_49495_entity",
"type": "progene_text",
"text": [
"sIL-6R"
],
"offsets": [
[
34,
40
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30532 | split_0_train_30532 | [
{
"id": "split_0_train_30532_passage",
"type": "progene_text",
"text": [
"Ana o 3 , an important cashew nut ( Anacardium occidentale L. ) allergen of the 2S albumin family ."
],
"offsets": [
[
0,
99
]
]
}
] | [
{
"id": "split_0_train_49496_entity",
"type": "progene_text",
"text": [
"Ana o 3"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_49497_entity",
"type": "progene_text",
"text": [
"2S albumin family"
],
"offsets": [
[
80,
97
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30533 | split_0_train_30533 | [
{
"id": "split_0_train_30533_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] | [] | [] | [] | [] |
split_0_train_30534 | split_0_train_30534 | [
{
"id": "split_0_train_30534_passage",
"type": "progene_text",
"text": [
"Cashew nut allergy is the second most commonly reported tree nut allergy in the United States ."
],
"offsets": [
[
0,
95
]
]
}
] | [] | [] | [] | [] |
split_0_train_30535 | split_0_train_30535 | [
{
"id": "split_0_train_30535_passage",
"type": "progene_text",
"text": [
"We have previously cloned and characterized major cashew allergens belonging to the vicilin and legumin families of seed storage proteins ."
],
"offsets": [
[
0,
139
]
]
}
] | [
{
"id": "split_0_train_49498_entity",
"type": "progene_text",
"text": [
"vicilin and legumin families"
],
"offsets": [
[
84,
112
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30536 | split_0_train_30536 | [
{
"id": "split_0_train_30536_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
] | [] | [] | [] | [] |
split_0_train_30537 | split_0_train_30537 | [
{
"id": "split_0_train_30537_passage",
"type": "progene_text",
"text": [
"Here we set out to describe a third major cashew allergen , a 2S albumin ."
],
"offsets": [
[
0,
74
]
]
}
] | [
{
"id": "split_0_train_49499_entity",
"type": "progene_text",
"text": [
"2S albumin"
],
"offsets": [
[
62,
72
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30538 | split_0_train_30538 | [
{
"id": "split_0_train_30538_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_30539 | split_0_train_30539 | [
{
"id": "split_0_train_30539_passage",
"type": "progene_text",
"text": [
"The recombinant cashew 2S albumin was amplified from a cDNA library by means of PCR , sequenced , and expressed in Escherichia coli ."
],
"offsets": [
[
0,
133
]
]
}
] | [
{
"id": "split_0_train_49500_entity",
"type": "progene_text",
"text": [
"2S albumin"
],
"offsets": [
[
23,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30540 | split_0_train_30540 | [
{
"id": "split_0_train_30540_passage",
"type": "progene_text",
"text": [
"Immunoblotting was used to screen for reactivity with patients ' sera , and inhibition immunoblotting was used to identify the corresponding native cashew nut proteins ."
],
"offsets": [
[
0,
169
]
]
}
] | [] | [] | [] | [] |
split_0_train_30541 | split_0_train_30541 | [
{
"id": "split_0_train_30541_passage",
"type": "progene_text",
"text": [
"The mass of affinity - purified native allergen was determined by means of matrix - assisted laser desorption ionization - time of flight ( MALDI - TOF ) mass spectroscopy ."
],
"offsets": [
[
0,
173
]
]
}
] | [] | [] | [] | [] |
split_0_train_30542 | split_0_train_30542 | [
{
"id": "split_0_train_30542_passage",
"type": "progene_text",
"text": [
"Patients ' sera were used to probe solid-phase 2S albumin peptides to identify linear epitopes ."
],
"offsets": [
[
0,
96
]
]
}
] | [
{
"id": "split_0_train_49501_entity",
"type": "progene_text",
"text": [
"2S albumin"
],
"offsets": [
[
47,
57
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30543 | split_0_train_30543 | [
{
"id": "split_0_train_30543_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_30544 | split_0_train_30544 | [
{
"id": "split_0_train_30544_passage",
"type": "progene_text",
"text": [
"The cloned allergen , designated Ana o 3 , was identified as 2S albumin ."
],
"offsets": [
[
0,
73
]
]
}
] | [
{
"id": "split_0_train_49502_entity",
"type": "progene_text",
"text": [
"Ana o 3"
],
"offsets": [
[
33,
40
]
],
"normalized": []
},
{
"id": "split_0_train_49503_entity",
"type": "progene_text",
"text": [
"2S albumin"
],
"offsets": [
[
61,
71
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30545 | split_0_train_30545 | [
{
"id": "split_0_train_30545_passage",
"type": "progene_text",
"text": [
"MALDI - TOF mass spectroscopy of native Ana o 3 yielded a molecular mass of 12 , 598 d ."
],
"offsets": [
[
0,
88
]
]
}
] | [
{
"id": "split_0_train_49504_entity",
"type": "progene_text",
"text": [
"Ana o 3"
],
"offsets": [
[
40,
47
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30546 | split_0_train_30546 | [
{
"id": "split_0_train_30546_passage",
"type": "progene_text",
"text": [
"Immunoblot analysis showed 21 ( 81 % ) of 26 sera from patients with cashew allergy were reactive ."
],
"offsets": [
[
0,
99
]
]
}
] | [] | [] | [] | [] |
split_0_train_30547 | split_0_train_30547 | [
{
"id": "split_0_train_30547_passage",
"type": "progene_text",
"text": [
"Three native Ana o 3 large - subunit isoforms with molecular weights ranging from approximately 6 to 10 kd were identified ."
],
"offsets": [
[
0,
124
]
]
}
] | [
{
"id": "split_0_train_49505_entity",
"type": "progene_text",
"text": [
"Ana o 3"
],
"offsets": [
[
13,
20
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30548 | split_0_train_30548 | [
{
"id": "split_0_train_30548_passage",
"type": "progene_text",
"text": [
"Probing of overlapping synthetic Ana o 3 peptides with patients ' sera identified 16 reactive peptides , 4 of which gave strong signals and one of which positionally overlaps linear epitopes in mustard and walnut allergenic 2S albumins ."
],
"offsets": [
[
0,
237
]
]
}
] | [
{
"id": "split_0_train_49506_entity",
"type": "progene_text",
"text": [
"Ana o 3"
],
"offsets": [
[
33,
40
]
],
"normalized": []
},
{
"id": "split_0_train_49507_entity",
"type": "progene_text",
"text": [
"2S albumins"
],
"offsets": [
[
224,
235
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30549 | split_0_train_30549 | [
{
"id": "split_0_train_30549_passage",
"type": "progene_text",
"text": [
"The overlapping cashew and walnut epitopes also share considerable homology ."
],
"offsets": [
[
0,
77
]
]
}
] | [] | [] | [] | [] |
split_0_train_30550 | split_0_train_30550 | [
{
"id": "split_0_train_30550_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] | [] | [] | [] | [] |
split_0_train_30551 | split_0_train_30551 | [
{
"id": "split_0_train_30551_passage",
"type": "progene_text",
"text": [
"We conclude that this 2S albumin protein is a major allergen in cashew nut and demonstrates a possible basis for cross - reactivity with walnut 2S albumin ."
],
"offsets": [
[
0,
156
]
]
}
] | [
{
"id": "split_0_train_49508_entity",
"type": "progene_text",
"text": [
"2S albumin"
],
"offsets": [
[
22,
32
]
],
"normalized": []
},
{
"id": "split_0_train_49509_entity",
"type": "progene_text",
"text": [
"2S albumin"
],
"offsets": [
[
144,
154
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30552 | split_0_train_30552 | [
{
"id": "split_0_train_30552_passage",
"type": "progene_text",
"text": [
"New lnu(C) gene conferring resistance to lincomycin by nucleotidylation in Streptococcus agalactiae UCN36 ."
],
"offsets": [
[
0,
107
]
]
}
] | [
{
"id": "split_0_train_49510_entity",
"type": "progene_text",
"text": [
"lnu(C)"
],
"offsets": [
[
4,
10
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30553 | split_0_train_30553 | [
{
"id": "split_0_train_30553_passage",
"type": "progene_text",
"text": [
"Streptococcus agalactiae UCN36 was resistant to lincomycin ( MIC = 16 microg / ml ) but susceptible to clindamycin ( MIC = 0.12 microg / ml ) and erythromycin ( MIC = 0.06 microg / ml ) ."
],
"offsets": [
[
0,
187
]
]
}
] | [] | [] | [] | [] |
split_0_train_30554 | split_0_train_30554 | [
{
"id": "split_0_train_30554_passage",
"type": "progene_text",
"text": [
"A 4 - kb HindIII fragment was cloned from S. agalactiae UCN36 total DNA on plasmid pUC18 and introduced into Escherichia coli AG100A , where it conferred resistance to lincomycin ."
],
"offsets": [
[
0,
180
]
]
}
] | [
{
"id": "split_0_train_49511_entity",
"type": "progene_text",
"text": [
"HindIII"
],
"offsets": [
[
9,
16
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30555 | split_0_train_30555 | [
{
"id": "split_0_train_30555_passage",
"type": "progene_text",
"text": [
"The sequence analysis of the fragment showed the presence of a 1,724-bp element delineated by imperfect inverted repeats ( 22 of 25 bp ) and inserted in the operon for capsular synthesis of S. agalactiae UCN36 ."
],
"offsets": [
[
0,
211
]
]
}
] | [] | [] | [] | [] |
split_0_train_30556 | split_0_train_30556 | [
{
"id": "split_0_train_30556_passage",
"type": "progene_text",
"text": [
"This element carried two open reading frames ( ORF ) ."
],
"offsets": [
[
0,
54
]
]
}
] | [] | [] | [] | [] |
split_0_train_30557 | split_0_train_30557 | [
{
"id": "split_0_train_30557_passage",
"type": "progene_text",
"text": [
"The deduced amino acid sequence of the upstream ORF displayed similarity with transposases from anaerobes and IS1 ."
],
"offsets": [
[
0,
115
]
]
}
] | [
{
"id": "split_0_train_49512_entity",
"type": "progene_text",
"text": [
"transposases"
],
"offsets": [
[
78,
90
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30558 | split_0_train_30558 | [
{
"id": "split_0_train_30558_passage",
"type": "progene_text",
"text": [
"The downstream ORF , lnu ( C ) , encoded a 164 - amino - acid protein with 26 % to 27 % identity with the LnuA ( N2 ) , LnuA , and LnuA ' lincosamide nucleotidyltransferases reported for Bacteroides and Staphylococcus , respectively ."
],
"offsets": [
[
0,
234
]
]
}
] | [
{
"id": "split_0_train_49513_entity",
"type": "progene_text",
"text": [
"lnu ( C )"
],
"offsets": [
[
21,
30
]
],
"normalized": []
},
{
"id": "split_0_train_49514_entity",
"type": "progene_text",
"text": [
"LnuA"
],
"offsets": [
[
106,
110
]
],
"normalized": []
},
{
"id": "split_0_train_49515_entity",
"type": "progene_text",
"text": [
"LnuA"
],
"offsets": [
[
120,
124
]
],
"normalized": []
},
{
"id": "split_0_train_49516_entity",
"type": "progene_text",
"text": [
"LnuA"
],
"offsets": [
[
131,
135
]
],
"normalized": []
},
{
"id": "split_0_train_49517_entity",
"type": "progene_text",
"text": [
"nucleotidyltransferases"
],
"offsets": [
[
150,
173
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30559 | split_0_train_30559 | [
{
"id": "split_0_train_30559_passage",
"type": "progene_text",
"text": [
"Crude lysates of E. coli AG100A containing the cloned lnu ( C ) gene inactivated lincomycin and clindamycin in the presence of ATP and MgCl2 ."
],
"offsets": [
[
0,
142
]
]
}
] | [
{
"id": "split_0_train_49518_entity",
"type": "progene_text",
"text": [
"lnu ( C )"
],
"offsets": [
[
54,
63
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30560 | split_0_train_30560 | [
{
"id": "split_0_train_30560_passage",
"type": "progene_text",
"text": [
"Mass spectrometry experiments demonstrated that the LnuC enzyme catalyzed adenylylation of lincomycin ."
],
"offsets": [
[
0,
103
]
]
}
] | [
{
"id": "split_0_train_49519_entity",
"type": "progene_text",
"text": [
"LnuC"
],
"offsets": [
[
52,
56
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30561 | split_0_train_30561 | [
{
"id": "split_0_train_30561_passage",
"type": "progene_text",
"text": [
"Deletion of Cg - emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan , whereas inactivation of Cg - ubiA results in an arabinan - deficient mutant with a cell wall galactan core ."
],
"offsets": [
[
0,
206
]
]
}
] | [
{
"id": "split_0_train_49520_entity",
"type": "progene_text",
"text": [
"emb"
],
"offsets": [
[
17,
20
]
],
"normalized": []
},
{
"id": "split_0_train_49521_entity",
"type": "progene_text",
"text": [
"ubiA"
],
"offsets": [
[
127,
131
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30562 | split_0_train_30562 | [
{
"id": "split_0_train_30562_passage",
"type": "progene_text",
"text": [
"The cell wall of Mycobacterium tuberculosis has a complex ultrastructure that consists of mycolic acids connected to peptidoglycan via arabinogalactan ( AG ) and abbreviated as the mAGP complex ."
],
"offsets": [
[
0,
195
]
]
}
] | [] | [] | [] | [] |
split_0_train_30563 | split_0_train_30563 | [
{
"id": "split_0_train_30563_passage",
"type": "progene_text",
"text": [
"The mAGP complex is crucial for the survival and pathogenicity of M. tuberculosis and is the target of several anti - tubercular agents ."
],
"offsets": [
[
0,
137
]
]
}
] | [] | [] | [] | [] |
split_0_train_30564 | split_0_train_30564 | [
{
"id": "split_0_train_30564_passage",
"type": "progene_text",
"text": [
"Apart from sharing a similar mAGP and the availability of the complete genome sequence , Corynebacterium glutamicum has proven useful in the study of orthologous M. tuberculosis genes essential for viability ."
],
"offsets": [
[
0,
209
]
]
}
] | [] | [] | [] | [] |
split_0_train_30565 | split_0_train_30565 | [
{
"id": "split_0_train_30565_passage",
"type": "progene_text",
"text": [
"Here we examined the effects of particular genes involved in AG polymerization by gene deletion in C. glutamicum ."
],
"offsets": [
[
0,
114
]
]
}
] | [] | [] | [] | [] |
split_0_train_30566 | split_0_train_30566 | [
{
"id": "split_0_train_30566_passage",
"type": "progene_text",
"text": [
"The anti - tuberculosis drug ethambutol is thought to target a set of arabinofuranosyltransferases ( Emb ) that are involved in arabinan polymerization ."
],
"offsets": [
[
0,
153
]
]
}
] | [
{
"id": "split_0_train_49522_entity",
"type": "progene_text",
"text": [
"arabinofuranosyltransferases"
],
"offsets": [
[
70,
98
]
],
"normalized": []
},
{
"id": "split_0_train_49523_entity",
"type": "progene_text",
"text": [
"Emb"
],
"offsets": [
[
101,
104
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30567 | split_0_train_30567 | [
{
"id": "split_0_train_30567_passage",
"type": "progene_text",
"text": [
"Deletion of emb in C. glutamicum results in a slow growing mutant with profound morphological changes ."
],
"offsets": [
[
0,
103
]
]
}
] | [
{
"id": "split_0_train_49524_entity",
"type": "progene_text",
"text": [
"emb"
],
"offsets": [
[
12,
15
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30568 | split_0_train_30568 | [
{
"id": "split_0_train_30568_passage",
"type": "progene_text",
"text": [
"Chemical analysis revealed a dramatic reduction of arabinose resulting in a novel truncated AG structure possessing only terminal arabinofuranoside ( t - Araf ) residues with a corresponding loss of cell wall bound mycolic acids ."
],
"offsets": [
[
0,
230
]
]
}
] | [] | [] | [] | [] |
split_0_train_30569 | split_0_train_30569 | [
{
"id": "split_0_train_30569_passage",
"type": "progene_text",
"text": [
"Treatment of wild - type C. glutamicum with ethambutol and subsequent cell wall analyses resulted in an identical phenotype comparable to the C. glutamicum emb deletion mutant ."
],
"offsets": [
[
0,
177
]
]
}
] | [
{
"id": "split_0_train_49525_entity",
"type": "progene_text",
"text": [
"emb"
],
"offsets": [
[
156,
159
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30570 | split_0_train_30570 | [
{
"id": "split_0_train_30570_passage",
"type": "progene_text",
"text": [
"Additionally , disruption of ubiA in C. glutamicum , the first enzyme involved in the biosynthesis of the sugar donor decaprenol phosphoarabinose ( DPA ) , resulted in a complete loss of cell wall arabinan ."
],
"offsets": [
[
0,
207
]
]
}
] | [
{
"id": "split_0_train_49526_entity",
"type": "progene_text",
"text": [
"ubiA"
],
"offsets": [
[
29,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30571 | split_0_train_30571 | [
{
"id": "split_0_train_30571_passage",
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"text": [
"Herein , we establish for the first time , (i) that in contrast to M. tuberculosis embA and embB mutants , deletion of C. glutamicum emb leads to a highly truncated AG possessing t - Araf residues , (ii) the exact site of attachment of arabinan chains in AG , and (iii) DPA is the only Araf sugar donor in AG biosynthesis suggesting the presence of a novel enzyme responsible for \" priming \" the galactan domain for further elaboration by Emb , resulting in the final maturation of the native AG polysaccharide ."
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] | [
{
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{
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92,
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{
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"emb"
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{
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"text": [
"Emb"
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439,
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}
] | [] | [] | [] |
split_0_train_30572 | split_0_train_30572 | [
{
"id": "split_0_train_30572_passage",
"type": "progene_text",
"text": [
"Phylogeny of the insect homeobox gene ( hox ) cluster ."
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0,
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{
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"type": "progene_text",
"text": [
"hox"
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40,
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}
] | [] | [] | [] |
split_0_train_30573 | split_0_train_30573 | [
{
"id": "split_0_train_30573_passage",
"type": "progene_text",
"text": [
"The homeobox ( Hox ) genes form an evolutionarily conserved family encoding transcription factors that play major roles in segmental identity and organ specification across species ."
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0,
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"text": [
"transcription factors"
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76,
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}
] | [] | [] | [] |
split_0_train_30574 | split_0_train_30574 | [
{
"id": "split_0_train_30574_passage",
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"text": [
"The canonical grouping of Hox genes present in the HOM-C cluster of Drosophila or related clusters in other organisms includes eight \" typical \" genes , which are localized in the order labial ( lab ) , proboscipedia ( pb ) , Deformed ( Dfd ) , Sex combs reduced ( Scr ) , Antennapedia ( Antp ) , Ultrabithorax ( Ubx ) , abdominalA ( abdA ) , and AbdominalB ( AbdB ) ."
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{
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{
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"pb"
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219,
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{
"id": "split_0_train_49542_entity",
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226,
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{
"id": "split_0_train_49543_entity",
"type": "progene_text",
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{
"id": "split_0_train_49544_entity",
"type": "progene_text",
"text": [
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245,
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{
"id": "split_0_train_49545_entity",
"type": "progene_text",
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265,
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{
"id": "split_0_train_49546_entity",
"type": "progene_text",
"text": [
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273,
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{
"id": "split_0_train_49547_entity",
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{
"id": "split_0_train_49548_entity",
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297,
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{
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313,
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{
"id": "split_0_train_49550_entity",
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321,
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{
"id": "split_0_train_49551_entity",
"type": "progene_text",
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{
"id": "split_0_train_49552_entity",
"type": "progene_text",
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347,
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{
"id": "split_0_train_49553_entity",
"type": "progene_text",
"text": [
"AbdB"
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[
360,
364
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30575 | split_0_train_30575 | [
{
"id": "split_0_train_30575_passage",
"type": "progene_text",
"text": [
"The members of Hox cluster are expressed in a distinct anterior to posterior order in the embryo ."
],
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[
0,
98
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]
}
] | [
{
"id": "split_0_train_49554_entity",
"type": "progene_text",
"text": [
"Hox"
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"offsets": [
[
15,
18
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30576 | split_0_train_30576 | [
{
"id": "split_0_train_30576_passage",
"type": "progene_text",
"text": [
"Analysis of the relatedness of different members of the Hox gene cluster to each other in four evolutionarily diverse insect taxa revealed that the loci pb / Dfd and AbdB , which are farthest apart in linkage , had a high degree of evolutionary relatedness , indicating that pb / Dfd type anterior genes and AbdB are closest to the ancestral anterior and posterior Hox genes , respectively ."
],
"offsets": [
[
0,
391
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]
}
] | [
{
"id": "split_0_train_49555_entity",
"type": "progene_text",
"text": [
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56,
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{
"id": "split_0_train_49556_entity",
"type": "progene_text",
"text": [
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153,
155
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{
"id": "split_0_train_49557_entity",
"type": "progene_text",
"text": [
"Dfd"
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158,
161
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],
"normalized": []
},
{
"id": "split_0_train_49558_entity",
"type": "progene_text",
"text": [
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166,
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{
"id": "split_0_train_49559_entity",
"type": "progene_text",
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"pb"
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275,
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},
{
"id": "split_0_train_49560_entity",
"type": "progene_text",
"text": [
"Dfd"
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280,
283
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],
"normalized": []
},
{
"id": "split_0_train_49561_entity",
"type": "progene_text",
"text": [
"AbdB"
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308,
312
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},
{
"id": "split_0_train_49562_entity",
"type": "progene_text",
"text": [
"Hox"
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"offsets": [
[
365,
368
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30577 | split_0_train_30577 | [
{
"id": "split_0_train_30577_passage",
"type": "progene_text",
"text": [
"The greater relatedness of other posterior genes Ubx and abdA to the more anterior genes such as Antp and Scr suggested that they arose by gene duplications in the more anterior members rather than the posterior AbdB ."
],
"offsets": [
[
0,
218
]
]
}
] | [
{
"id": "split_0_train_49563_entity",
"type": "progene_text",
"text": [
"Ubx"
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49,
52
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],
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},
{
"id": "split_0_train_49564_entity",
"type": "progene_text",
"text": [
"abdA"
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57,
61
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],
"normalized": []
},
{
"id": "split_0_train_49565_entity",
"type": "progene_text",
"text": [
"Antp"
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97,
101
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],
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},
{
"id": "split_0_train_49566_entity",
"type": "progene_text",
"text": [
"Scr"
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106,
109
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],
"normalized": []
},
{
"id": "split_0_train_49567_entity",
"type": "progene_text",
"text": [
"AbdB"
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"offsets": [
[
212,
216
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30578 | split_0_train_30578 | [
{
"id": "split_0_train_30578_passage",
"type": "progene_text",
"text": [
"KIR3DL1 polymorphisms that affect NK cell inhibition by HLA-Bw4 ligand ."
],
"offsets": [
[
0,
72
]
]
}
] | [
{
"id": "split_0_train_49568_entity",
"type": "progene_text",
"text": [
"KIR3DL1"
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0,
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},
{
"id": "split_0_train_49569_entity",
"type": "progene_text",
"text": [
"HLA-Bw4"
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[
56,
63
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30579 | split_0_train_30579 | [
{
"id": "split_0_train_30579_passage",
"type": "progene_text",
"text": [
"The killer cell Ig - like receptor ( KIR ) gene family encodes MHC class I receptors expressed by NK cells and several T cell subpopulations ."
],
"offsets": [
[
0,
142
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]
}
] | [
{
"id": "split_0_train_49570_entity",
"type": "progene_text",
"text": [
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{
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"text": [
"MHC class I"
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63,
74
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30580 | split_0_train_30580 | [
{
"id": "split_0_train_30580_passage",
"type": "progene_text",
"text": [
"Factors contributing to human KIR haplotype diversity are differences in gene number , gene content , and allelic polymorphism ."
],
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[
0,
128
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]
}
] | [
{
"id": "split_0_train_49572_entity",
"type": "progene_text",
"text": [
"KIR"
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30,
33
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30581 | split_0_train_30581 | [
{
"id": "split_0_train_30581_passage",
"type": "progene_text",
"text": [
"Whereas functional and clinical consequences of the first two factors are established , knowledge of the effects of KIR gene polymorphism is limited to special cases in which signaling function is reversed or cell surface expression lost ."
],
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[
0,
239
]
]
}
] | [
{
"id": "split_0_train_49573_entity",
"type": "progene_text",
"text": [
"KIR"
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[
116,
119
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30582 | split_0_train_30582 | [
{
"id": "split_0_train_30582_passage",
"type": "progene_text",
"text": [
"In this study we use retrovirally transduced human cell lines to show that 3DL1*002 is a stronger inhibitory receptor for HLA-Bw4 ligands than 3DL1*007 ."
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[
0,
153
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]
}
] | [
{
"id": "split_0_train_49574_entity",
"type": "progene_text",
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75,
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{
"id": "split_0_train_49575_entity",
"type": "progene_text",
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122,
129
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{
"id": "split_0_train_49576_entity",
"type": "progene_text",
"text": [
"3DL1*007"
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[
143,
151
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30583 | split_0_train_30583 | [
{
"id": "split_0_train_30583_passage",
"type": "progene_text",
"text": [
"Analysis of mutant 3DL1*002 and 3DL1*007 molecules demonstrates that residue 238 in the D2 domain and 320 in the transmembrane region contribute to the difference in receptor strength ."
],
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[
0,
185
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]
}
] | [
{
"id": "split_0_train_49577_entity",
"type": "progene_text",
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19,
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{
"id": "split_0_train_49578_entity",
"type": "progene_text",
"text": [
"3DL1*007"
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[
32,
40
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30584 | split_0_train_30584 | [
{
"id": "split_0_train_30584_passage",
"type": "progene_text",
"text": [
"Neither position 238 nor 320 is predicted to interact directly with HLA-Bw4 ligand ."
],
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[
0,
84
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]
}
] | [
{
"id": "split_0_train_49579_entity",
"type": "progene_text",
"text": [
"HLA-Bw4"
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[
68,
75
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30585 | split_0_train_30585 | [
{
"id": "split_0_train_30585_passage",
"type": "progene_text",
"text": [
"This study also revealed that KIR3DL1 and LILRB1 both contribute to developing an inhibitory response to HLA-Bw4 ligands ."
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[
0,
122
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]
}
] | [
{
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"type": "progene_text",
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30,
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{
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42,
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{
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"text": [
"HLA-Bw4"
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[
105,
112
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30586 | split_0_train_30586 | [
{
"id": "split_0_train_30586_passage",
"type": "progene_text",
"text": [
"F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein ."
],
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[
0,
113
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}
] | [
{
"id": "split_0_train_49583_entity",
"type": "progene_text",
"text": [
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0,
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{
"id": "split_0_train_49584_entity",
"type": "progene_text",
"text": [
"apolipoprotein E receptor"
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31,
56
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{
"id": "split_0_train_49585_entity",
"type": "progene_text",
"text": [
"ApoEr2"
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57,
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{
"id": "split_0_train_49586_entity",
"type": "progene_text",
"text": [
"amyloid precursor protein"
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[
86,
111
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30587 | split_0_train_30587 | [
{
"id": "split_0_train_30587_passage",
"type": "progene_text",
"text": [
"A recent study showed that F-spondin , a protein associated with the extracellular matrix , interacted with amyloid precursor protein ( APP ) and inhibited beta - secretase cleavage ."
],
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[
0,
183
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]
}
] | [
{
"id": "split_0_train_49587_entity",
"type": "progene_text",
"text": [
"F-spondin"
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27,
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{
"id": "split_0_train_49588_entity",
"type": "progene_text",
"text": [
"amyloid precursor protein"
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108,
133
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{
"id": "split_0_train_49589_entity",
"type": "progene_text",
"text": [
"APP"
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136,
139
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],
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{
"id": "split_0_train_49590_entity",
"type": "progene_text",
"text": [
"beta - secretase"
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[
156,
172
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30588 | split_0_train_30588 | [
{
"id": "split_0_train_30588_passage",
"type": "progene_text",
"text": [
"F-spondin contains a thrombospondin domain that we hypothesized could interact with the family of receptors for apolipoprotein E ( apoE ) ."
],
"offsets": [
[
0,
139
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]
}
] | [
{
"id": "split_0_train_49591_entity",
"type": "progene_text",
"text": [
"F-spondin"
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9
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{
"id": "split_0_train_49592_entity",
"type": "progene_text",
"text": [
"thrombospondin"
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21,
35
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],
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},
{
"id": "split_0_train_49593_entity",
"type": "progene_text",
"text": [
"family of receptors for apolipoprotein E"
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88,
128
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},
{
"id": "split_0_train_49594_entity",
"type": "progene_text",
"text": [
"apoE"
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"offsets": [
[
131,
135
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30589 | split_0_train_30589 | [
{
"id": "split_0_train_30589_passage",
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split_0_train_30596 | split_0_train_30596 | [
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split_0_train_30597 | split_0_train_30597 | [
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split_0_train_30598 | split_0_train_30598 | [
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