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<|startoftext|><L>COc1cccc(OC)c1C(=<mask_1:3>1ccc(Oc2cccnc2)cc1<mask_1:3> | 4 | 17 | 3 | O)Nc | 3 | COc1cccc(OC)c1C(=O)c1ccc(Oc2cccnc2)cc1 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | O)c |
<|startoftext|><L>COc1cccc(OC)c1C(<mask_1:2>O)Nc1ccc(Oc2cccnc2)cc1<mask_1:2> | 1 | 16 | 2 | = | 2 | COc1cccc(OC)c1C(=NO)Nc1ccc(Oc2cccnc2)cc1 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | =N |
<|startoftext|><L>COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2<mask_1:4>cc1<mask_1:4> | 1 | 35 | 4 | ) | 4 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2C#N)cc1 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | C#N) |
<|startoftext|><L>COc1cccc(OC)c1C(=O)<mask_1:4>1ccc(Oc2cccnc2)cc1<mask_1:4> | 2 | 19 | 4 | Nc | 4 | COc1cccc(OC)c1C(=O)NCCc1ccc(Oc2cccnc2)cc1 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | NCCc |
<|startoftext|><L>COc1cccc(OC)c<mask_1:4>(=O)Nc1ccc(Oc2cccnc2)cc1<mask_1:4> | 2 | 13 | 4 | 1C | 4 | COc1cccc(OC)c1CNC(=O)Nc1ccc(Oc2cccnc2)cc1 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | 1CNC |
<|startoftext|><L>COc1cccc(OC)c1C(=O)Nc1ccc(Oc2c<mask_1:5>c2)cc1<mask_1:5> | 3 | 30 | 5 | ccn | 5 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cnn(C)c2)cc1 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | nn(C) |
<|startoftext|><L>COc1cccc(OC<mask_1:3>c1C(=O)Nc1ccc(Oc2cccnc2)cc1<mask_1:3> | 1 | 11 | 3 | ) | 3 | COc1cccc(OCCO)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | CO) |
<|startoftext|><L>COc1cccc(OC)c1C(=O)Nc1ccc(Oc<mask_1:2>nc2)cc1<mask_1:2> | 4 | 28 | 2 | 2ccc | 2 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2nnc2)cc1 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | 2n |
<|startoftext|><L>COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cc<mask_1:5>c2)cc1<mask_1:5> | 2 | 31 | 5 | cn | 5 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2ccc(C)cc2)cc1 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | c(C)c |
<|startoftext|><L>COc1cccc(OC)c1<mask_1:3>(=O)Nc1ccc(Oc2cccnc2)cc1<mask_1:3> | 1 | 14 | 3 | C | 3 | COc1cccc(OC)c1OCC(=O)Nc1ccc(Oc2cccnc2)cc1 | COc1cccc(OC)c1C(=O)Nc1ccc(Oc2cccnc2)cc1 | OCC |
<|startoftext|><L>COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[<mask_1:6>@H](C(N)=O)C1<mask_1:6> | 1 | 34 | 6 | C | 6 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H][C@H](C(N)=O)C1 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | C@H][C |
<|startoftext|><L>COC[C@@H](C<mask_1:5>)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1<mask_1:5> | 0 | 11 | 5 | 5 | COC[C@@H](C)C(=O)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | )C(=O |
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<|startoftext|><L>COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@<mask_1:2>](C(N)=O)C1<mask_1:2> | 1 | 36 | 2 | H | 2 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@@H](C(N)=O)C1 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | @H |
<|startoftext|><L>COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@<mask_1:5>C(N)=O)C1<mask_1:5> | 3 | 36 | 5 | H]( | 5 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@@H](CC(N)=O)C1 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | @H](C |
<|startoftext|><L><mask_1:3>C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1<mask_1:3> | 4 | 0 | 3 | COC[ | 3 | CC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | CC[ |
<|startoftext|><L>COC[C@@H](C)NC(=O)N<mask_1:7>Cc1cccnc1N1CCC[C@H](C(N)=O)C1<mask_1:7> | 0 | 19 | 7 | 7 | COC[C@@H](C)NC(=O)NC(=O)NCCc1cccnc1N1CCC[C@H](C(N)=O)C1 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | C(=O)NC |
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<|startoftext|><L>COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C<mask_1:6>O)C1<mask_1:6> | 4 | 40 | 6 | (N)= | 6 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](CNC(N)=O)C1 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | NC(N)= |
<|startoftext|><L>COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H]<mask_1:3>=O)C1<mask_1:3> | 5 | 38 | 3 | (C(N) | 3 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](NC=O)C1 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | (NC |
<|startoftext|><L>COC[C@@<mask_1:1>C(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1<mask_1:1> | 6 | 7 | 1 | H](C)N | 1 | COC[C@@]C(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | ] |
<|startoftext|><L>COC[C@@H]<mask_1:3>C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1<mask_1:3> | 1 | 9 | 3 | ( | 3 | COC[C@@H](COC)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | COC[C@@H](C)NC(=O)NCc1cccnc1N1CCC[C@H](C(N)=O)C1 | (CO |
<|startoftext|><L>Cc1nc2c(OCc3ccn<mask_1:3>4CCCC4)n3)cccc2o1<mask_1:3> | 2 | 15 | 3 | (C | 3 | Cc1nc2c(OCc3ccnc(C4CCCC4)n3)cccc2o1 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | c(C |
<|startoftext|><L>Cc1<mask_1:5>2c(OCc3ccn(C4CCCC4)n3)cccc2o1<mask_1:5> | 2 | 3 | 5 | nc | 5 | Cc1c(C)c2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | c(C)c |
<|startoftext|><L>Cc1nc<mask_1:1>(OCc3ccn(C4CCCC4)n3)cccc2o1<mask_1:1> | 2 | 5 | 1 | 2c | 1 | Cc1nc2(OCc3ccn(C4CCCC4)n3)cccc2o1 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | 2 |
<|startoftext|><L>Cc1nc2c(OCc3ccn(C4CC<mask_1:5>CC4)n3)cccc2o1<mask_1:5> | 0 | 20 | 5 | 5 | Cc1nc2c(OCc3ccn(C4CCN(C)CCC4)n3)cccc2o1 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | N(C)C |
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<|startoftext|><L>Cc1nc2c(<mask_1:3>OCc3ccn(C4CCCC4)n3)cccc2o1<mask_1:3> | 0 | 8 | 3 | 3 | Cc1nc2c(NCCOCc3ccn(C4CCCC4)n3)cccc2o1 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | NCC |
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<|startoftext|><L>Cc1nc2c(OCc3c<mask_1:5>C4CCCC4)n3)cccc2o1<mask_1:5> | 3 | 13 | 5 | cn( | 5 | Cc1nc2c(OCc3ccnc(NC4CCCC4)n3)cccc2o1 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | cnc(N |
<|startoftext|><L>Cc1nc2c(<mask_1:3>Cc3ccn(C4CCCC4)n3)cccc2o1<mask_1:3> | 1 | 8 | 3 | O | 3 | Cc1nc2c(CNCCc3ccn(C4CCCC4)n3)cccc2o1 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | CNC |
<|startoftext|><L>Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2<mask_1:5>o1<mask_1:5> | 0 | 32 | 5 | 5 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2c(=O)o1 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | c(=O) |
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<|startoftext|><L>Cc1nc2c(OCc3ccn(C<mask_1:4>CCCC4)n3)cccc2o1<mask_1:4> | 1 | 17 | 4 | 4 | 4 | Cc1nc2c(OCc3ccn(C4(F)CCCC4)n3)cccc2o1 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | 4(F) |
<|startoftext|><L>Cc1nc2c(OCc3ccn(<mask_1:3>CC4)n3)cccc2o1<mask_1:3> | 4 | 16 | 3 | C4CC | 3 | Cc1nc2c(OCc3ccn(C4CCC4)n3)cccc2o1 | Cc1nc2c(OCc3ccn(C4CCCC4)n3)cccc2o1 | C4C |
<|startoftext|><L>Cc1nccn1<mask_1:4>1ncc(NC(=O)Cn2cnc3ccccc32)cn1<mask_1:4> | 2 | 8 | 4 | -c | 4 | Cc1nccn1CCNc1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | CCNc |
<|startoftext|><L>Cc1nccn1-c1ncc(NC(=O)Cn<mask_1:1>c3ccccc32)cn1<mask_1:1> | 3 | 23 | 1 | 2cn | 1 | Cc1nccn1-c1ncc(NC(=O)Cn2c3ccccc32)cn1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | 2 |
<|startoftext|><L>Cc1nccn<mask_1:4>1ncc(NC(=O)Cn2cnc3ccccc32)cn1<mask_1:4> | 3 | 7 | 4 | 1-c | 4 | Cc1nccnc1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | c1-c |
<|startoftext|><L>Cc1nccn1-c1ncc(NC<mask_1:2>Cn2cnc3ccccc32)cn1<mask_1:2> | 4 | 17 | 2 | (=O) | 2 | Cc1nccn1-c1ncc(NCCCCn2cnc3ccccc32)cn1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | CC |
<|startoftext|><L><mask_1:5>1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1<mask_1:5> | 2 | 0 | 5 | Cc | 5 | CCCCc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | CCCCc |
<|startoftext|><L>Cc1ncc<mask_1:5>c1ncc(NC(=O)Cn2cnc3ccccc32)cn1<mask_1:5> | 3 | 6 | 5 | n1- | 5 | Cc1ncccc1CSc1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | cc1CS |
<|startoftext|><L>Cc1nccn1-c1ncc(NC(=O)Cn2cnc<mask_1:1>ccc32)cn1<mask_1:1> | 3 | 27 | 1 | 3cc | 1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccc32)cn1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | 3 |
<|startoftext|><L>Cc1nccn1<mask_1:5>-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1<mask_1:5> | 0 | 8 | 5 | 5 | Cc1nccn1CC(C)-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | CC(C) |
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<|startoftext|><L>Cc1nccn1-c1ncc(<mask_1:2>=O)Cn2cnc3ccccc32)cn1<mask_1:2> | 3 | 15 | 2 | NC( | 2 | Cc1nccn1-c1ncc(C(=O)Cn2cnc3ccccc32)cn1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | C( |
<|startoftext|><L>Cc1nccn1-c1ncc(NC(=O)C<mask_1:5>n2cnc3ccccc32)cn1<mask_1:5> | 0 | 22 | 5 | 5 | Cc1nccn1-c1ncc(NC(=O)C(C)CCn2cnc3ccccc32)cn1 | Cc1nccn1-c1ncc(NC(=O)Cn2cnc3ccccc32)cn1 | (C)CC |
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<|startoftext|><L>Cn1c(=O)c2c(ncn2<mask_1:3>c(F)cc2Br)n(C)c1=O<mask_1:3> | 5 | 16 | 3 | Cc2cc | 3 | Cn1c(=O)c2c(ncn2c2sc(F)cc2Br)n(C)c1=O | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | c2s |
<|startoftext|><L>Cn1c(=O)c2c(ncn2Cc2ccc<mask_1:4>cc2Br)n(C)c1=O<mask_1:4> | 3 | 22 | 4 | (F) | 4 | Cn1c(=O)c2c(ncn2Cc2ccc(Cl)cc2Br)n(C)c1=O | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | (Cl) |
<|startoftext|><L>Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2<mask_1:3>)n(C)c1=O<mask_1:3> | 2 | 28 | 3 | Br | 3 | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2C#N)n(C)c1=O | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | C#N |
<|startoftext|><L>Cn1c(=O<mask_1:3>c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O<mask_1:3> | 1 | 7 | 3 | ) | 3 | Cn1c(=O)cnc2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | )cn |
<|startoftext|><L>Cn1c(=O)c2c(ncn2Cc2cc<mask_1:4>c2Br)n(C)c1=O<mask_1:4> | 5 | 21 | 4 | c(F)c | 4 | Cn1c(=O)c2c(ncn2Cc2cc[nH]c2Br)n(C)c1=O | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | [nH] |
<|startoftext|><L>Cn1c(=O)c2c(ncn2Cc2ccc(F)<mask_1:2>)n(C)c1=O<mask_1:2> | 5 | 25 | 2 | cc2Br | 2 | Cn1c(=O)c2c(ncn2Cc2ccc(F)o2)n(C)c1=O | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | o2 |
<|startoftext|><L>Cn1c(=O)c2c(ncn2Cc2cc<mask_1:3>(F)cc2Br)n(C)c1=O<mask_1:3> | 1 | 21 | 3 | c | 3 | Cn1c(=O)c2c(ncn2Cc2cc(F)(F)cc2Br)n(C)c1=O | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | (F) |
<|startoftext|><L>Cn1c(=O)c2c(ncn2Cc2ccc(F)cc<mask_1:2>)n(C)c1=O<mask_1:2> | 3 | 27 | 2 | 2Br | 2 | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2F)n(C)c1=O | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | 2F |
<|startoftext|><L>Cn1c(=O)c2c(ncn2Cc2ccc(F)cc<mask_1:2>n(C)c1=O<mask_1:2> | 4 | 27 | 2 | 2Br) | 2 | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2)n(C)c1=O | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | 2) |
<|startoftext|><L>Cn1c<mask_1:2>2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O<mask_1:2> | 5 | 4 | 2 | (=O)c | 2 | Cn1cnc2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | Cn1c(=O)c2c(ncn2Cc2ccc(F)cc2Br)n(C)c1=O | nc |
<|startoftext|><L>CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC<mask_1:5>3)C1<mask_1:5> | 6 | 35 | 5 | (=O)CO | 5 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)C3)C1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | (=O)C |
<|startoftext|><L>CN1CCO[C@@H](CC<mask_1:4>C(=O)Cc2ccc3c(c2)NC(=O)CO3)C1<mask_1:4> | 1 | 15 | 4 | N | 4 | CN1CCO[C@@H](CCN(C)C(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | N(C) |
<|startoftext|><L>CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)<mask_1:1>CO3)C1<mask_1:1> | 6 | 33 | 1 | NC(=O) | 1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)OCO3)C1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | O |
<|startoftext|><L>CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)N<mask_1:6>CO3)C1<mask_1:6> | 5 | 34 | 6 | C(=O) | 6 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CCO3)C1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | C(=O)C |
<|startoftext|><L>CN1CCO[<mask_1:4>CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1<mask_1:4> | 6 | 7 | 4 | C@@H]( | 4 | CN1CCO[C@](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | C@]( |
<|startoftext|><L>CN1<mask_1:6>C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1<mask_1:6> | 4 | 3 | 6 | CCO[ | 6 | CN1CCCCC[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | CCCCC[ |
<|startoftext|><L>CN1CCO[C@@H](CC<mask_1:5>NC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1<mask_1:5> | 0 | 15 | 5 | 5 | CN1CCO[C@@H](CC(=O)NNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | (=O)N |
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<|startoftext|><L>CN1CCO[C@@H](CCNC(=O)Cc2cc<mask_1:6>c(c2)NC(=O)CO3)C1<mask_1:6> | 2 | 26 | 6 | c3 | 6 | CN1CCO[C@@H](CCNC(=O)Cc2cc(Cl)c3c(c2)NC(=O)CO3)C1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | (Cl)c3 |
<|startoftext|><L>CN1CCO[C@@H](CCNC(=O<mask_1:6>ccc3c(c2)NC(=O)CO3)C1<mask_1:6> | 4 | 20 | 6 | )Cc2 | 6 | CN1CCO[C@@H](CCNC(=O)NCCc2ccc3c(c2)NC(=O)CO3)C1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | )NCCc2 |
<|startoftext|><L>CN1CCO[C@@H](CCNC(=O)Cc2ccc3<mask_1:5>C(=O)CO3)C1<mask_1:5> | 6 | 28 | 5 | c(c2)N | 5 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)C(=O)CO3)C1 | CN1CCO[C@@H](CCNC(=O)Cc2ccc3c(c2)NC(=O)CO3)C1 | c(c2) |
<|startoftext|><L>CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=<mask_1:7>n2CC(C)C<mask_1:7> | 2 | 44 | 7 | O) | 7 | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)c(=O)n2CC(C)C | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | O)c(=O) |
<|startoftext|><L>CCOC(=O)c1cc(-c2ccc(C<mask_1:6>)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C<mask_1:6> | 1 | 21 | 6 | l | 6 | CCOC(=O)c1cc(-c2ccc(C(=O)OC)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | (=O)OC |
<|startoftext|><L>CCOC(=O)c1cc(-c2<mask_1:5>c(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C<mask_1:5> | 2 | 16 | 5 | cc | 5 | CCOC(=O)c1cc(-c2cc(F)c(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | cc(F) |
<|startoftext|><L>CCOC(=O)c1cc(-c2ccc(Cl)c<mask_1:6>c2c1c(=O)[nH]c(=O)n2CC(C)C<mask_1:6> | 4 | 24 | 6 | c2)n | 6 | CCOC(=O)c1cc(-c2ccc(Cl)cc2Cl)nc2c1c(=O)[nH]c(=O)n2CC(C)C | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | c2Cl)n |
<|startoftext|><L><mask_1:8>(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C<mask_1:8> | 4 | 0 | 8 | CCOC | 8 | CC(C)COC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | CC(C)COC |
<|startoftext|><L>CCOC<mask_1:4>)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C<mask_1:4> | 3 | 4 | 4 | (=O | 4 | CCOCC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | C(=O |
<|startoftext|><L>CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(<mask_1:4>(=O)n2CC(C)C<mask_1:4> | 8 | 34 | 4 | =O)[nH]c | 4 | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(C)nc(=O)n2CC(C)C | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | C)nc |
<|startoftext|><L>CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC<mask_1:3>C)C<mask_1:3> | 1 | 50 | 3 | ( | 3 | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CCOC(C)C | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | OC( |
<|startoftext|><L>CCOC(=O)c1cc(-c2ccc(Cl<mask_1:7>2)nc2c1c(=O)[nH]c(=O)n2CC(C)C<mask_1:7> | 3 | 22 | 7 | )cc | 7 | CCOC(=O)c1cc(-c2ccc(Cl)c(Cl)c2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | )c(Cl)c |
<|startoftext|><L>CCOC(=O)c1cc(-c2cc<mask_1:1>2)nc2c1c(=O)[nH]c(=O)n2CC(C)C<mask_1:1> | 7 | 18 | 1 | c(Cl)cc | 2 | CCOC(=O)c1cc(-c2ccco2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1c(=O)[nH]c(=O)n2CC(C)C | co |
<|startoftext|><L>CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2cc<mask_1:5>n1<mask_1:5> | 6 | 37 | 5 | ccc2)o | 5 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccco2)on1 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | co2)o |
<|startoftext|><L>CC(C)[C@@H](C)NC(=O)CNC<mask_1:5>(=O)c1cc(-c2ccccc2)on1<mask_1:5> | 0 | 23 | 5 | 5 | CC(C)[C@@H](C)NC(=O)CNC(=O)C(=O)c1cc(-c2ccccc2)on1 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | (=O)C |
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<|startoftext|><L>CC(C)[C@@H](C)NC<mask_1:4>C(=O)c1cc(-c2ccccc2)on1<mask_1:4> | 6 | 16 | 4 | (=O)CN | 4 | CC(C)[C@@H](C)NC(=O)C(=O)c1cc(-c2ccccc2)on1 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | (=O) |
<|startoftext|><L>CC(C)[C@@H](C)NC(=O)CNC(=<mask_1:5>cc(-c2ccccc2)on1<mask_1:5> | 4 | 25 | 5 | O)c1 | 5 | CC(C)[C@@H](C)NC(=O)CNC(=O)Cc1cc(-c2ccccc2)on1 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | O)Cc1 |
<|startoftext|><L>CC(C)[C@@H](C<mask_1:6>)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1<mask_1:6> | 0 | 13 | 6 | 6 | CC(C)[C@@H](CC(=O)O)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | C(=O)O |
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<|startoftext|><L>CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2cc<mask_1:6>cc2)on1<mask_1:6> | 1 | 37 | 6 | c | 6 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccc(C#N)cc2)on1 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | c(C#N) |
<|startoftext|><L><mask_1:6>(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1<mask_1:6> | 2 | 0 | 6 | CC | 6 | CC(C)C(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | CC(C)C |
<|startoftext|><L>CC(C)[C@@H](<mask_1:1>=O)CNC(=O)c1cc(-c2ccccc2)on1<mask_1:1> | 5 | 12 | 1 | C)NC( | 1 | CC(C)[C@@H](N=O)CNC(=O)c1cc(-c2ccccc2)on1 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | N |
<|startoftext|><L>CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c<mask_1:4>c2)on1<mask_1:4> | 5 | 34 | 4 | 2cccc | 4 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccsc2)on1 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | 2ccs |
<|startoftext|><L>CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2<mask_1:6>2)on1<mask_1:6> | 5 | 35 | 6 | ccccc | 5 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | CC(C)[C@@H](C)NC(=O)CNC(=O)c1cc(-c2ccccc2)on1 | ccccc |
<|startoftext|><L>CNc1ncccc1C(=O)N1C[C@@H](C<mask_1:7>O)O)[C@@H](c2cn(C)nn2)C1<mask_1:7> | 3 | 26 | 7 | C(= | 7 | CNc1ncccc1C(=O)N1C[C@@H](CN(C)C(=O)O)[C@@H](c2cn(C)nn2)C1 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | N(C)C(= |
<|startoftext|><L>CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2<mask_1:7>)nn2)C1<mask_1:7> | 4 | 42 | 7 | cn(C | 8 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C(C)C)nn2)C1 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | cn(C(C)C |
<|startoftext|><L>CNc1ncccc1C(=O)N1<mask_1:4>](CC(=O)O)[C@@H](c2cn(C)nn2)C1<mask_1:4> | 6 | 17 | 4 | C[C@@H | 4 | CNc1ncccc1C(=O)N1C[C@](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | C[C@ |
<|startoftext|><L>C<mask_1:5>1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1<mask_1:5> | 2 | 1 | 5 | Nc | 5 | CN(C)c1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | N(C)c |
<|startoftext|><L>CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C<mask_1:4>2)C1<mask_1:4> | 3 | 46 | 4 | )nn | 3 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | )nn |
<|startoftext|><L>CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)<mask_1:6>n2)C1<mask_1:6> | 1 | 47 | 6 | n | 6 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)c(COC)n2)C1 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | c(COC) |
<|startoftext|><L>CNc1ncccc1C(=O)N1C[C@@H](CC<mask_1:7>(=O)O)[C@@H](c2cn(C)nn2)C1<mask_1:7> | 0 | 27 | 7 | 7 | CNc1ncccc1C(=O)N1C[C@@H](CCNC(=O)C(=O)O)[C@@H](c2cn(C)nn2)C1 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | NC(=O)C |
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<|startoftext|><L>CNc1ncccc1C<mask_1:2>[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1<mask_1:2> | 7 | 11 | 2 | (=O)N1C | 2 | CNc1ncccc1CN1[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | N1 |
<|startoftext|><L>CNc1ncccc1C(=O)N1C[C@@H<mask_1:5>O)O)[C@@H](c2cn(C)nn2)C1<mask_1:5> | 6 | 23 | 5 | ](CC(= | 5 | CNc1ncccc1C(=O)N1C[C@@H](C(=O)O)[C@@H](c2cn(C)nn2)C1 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | ](C(= |
<|startoftext|><L>CNc1ncccc1C(=O)N1C[C@@H<mask_1:2>C(=O)O)[C@@H](c2cn(C)nn2)C1<mask_1:2> | 3 | 23 | 2 | ](C | 2 | CNc1ncccc1C(=O)N1C[C@@H](C(=O)O)[C@@H](c2cn(C)nn2)C1 | CNc1ncccc1C(=O)N1C[C@@H](CC(=O)O)[C@@H](c2cn(C)nn2)C1 | ]( |
<|startoftext|><L>O=C<mask_1:6>Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1<mask_1:6> | 1 | 3 | 6 | ( | 6 | O=C(/C=C/Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | (/C=C/ |
<|startoftext|><L>O=C(Cn1nnc(-c2ccc(<mask_1:3>cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1<mask_1:3> | 2 | 18 | 3 | F) | 3 | O=C(Cn1nnc(-c2ccc(Cl)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | Cl) |
<|startoftext|><L>O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N<mask_1:6>2cccs2)C[C@H]1c1ccco1<mask_1:6> | 4 | 30 | 6 | =C(c | 6 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(SCc2cccs2)C[C@H]1c1ccco1 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | =C(SCc |
<|startoftext|><L>O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cc<mask_1:5>C@H]1c1ccco1<mask_1:5> | 6 | 37 | 5 | cs2)C[ | 5 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2ccco2)[C@H]1c1ccco1 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | co2)[ |
<|startoftext|><L>O=C(Cn1nnc(-c2ccc(F)c<mask_1:8>2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1<mask_1:8> | 1 | 21 | 8 | c | 8 | O=C(Cn1nnc(-c2ccc(F)c(C(F)F)c2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | (C(F)F)c |
<|startoftext|><L>O=C(Cn1nnc(-c<mask_1:6>F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1<mask_1:6> | 5 | 13 | 6 | 2ccc( | 6 | O=C(Cn1nnc(-c2ccc(CF)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | 2ccc(C |
<|startoftext|><L>O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cc<mask_1:3>2)C[C@H]1c1ccco1<mask_1:3> | 2 | 37 | 3 | cs | 3 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2ccccc2)C[C@H]1c1ccco1 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | ccc |
<|startoftext|><L>O=C(Cn1nnc(-c2ccc(F)cc2<mask_1:7>C(c2cccs2)C[C@H]1c1ccco1<mask_1:7> | 8 | 23 | 7 | )n1)N1N= | 7 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1NC(c2cccs2)C[C@H]1c1ccco1 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | )n1)N1N |
<|startoftext|><L>O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1cc<mask_1:4>o1<mask_1:4> | 1 | 52 | 4 | c | 4 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccc(O)o1 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | c(O) |
<|startoftext|><L>O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2<mask_1:7>2)C[C@H]1c1ccco1<mask_1:7> | 4 | 35 | 7 | cccs | 7 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2ccc(F)o2)C[C@H]1c1ccco1 | O=C(Cn1nnc(-c2ccc(F)cc2)n1)N1N=C(c2cccs2)C[C@H]1c1ccco1 | ccc(F)o |