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---
language: rna
tags:
- Biology
- RNA
license:
- agpl-3.0
size_categories:
- 1K<n<10K
task_categories:
- text-generation
- fill-mask
task_ids:
- language-modeling
- masked-language-modeling
pretty_name: EternaBench-Switch
library_name: multimolecule
---
# EternaBench-Switch
EternaBench is a database comprising the diverse high-throughput structural data gathered through the crowdsourced RNA design project Eterna, to evaluate the performance of a wide set of structure algorithms.
## Disclaimer
This is an UNOFFICIAL release of the [EternaBench-Switch](https://github.com/eternagame/EternaBench) by Hannah K. Wayment-Steele, et al.
**The team releasing EternaBench-Switch did not write this dataset card for this dataset so this dataset card has been written by the MultiMolecule team.**
## Dataset Description
- **Homepage**: https://multimolecule.danling.org/datasets/eternabench_switch
- **datasets**: https://huggingface.co/datasets/multimolecule/eternabench-switch
- **Point of Contact**: [Rhiju Das](https://biochemistry.stanford.edu/people/rhiju-das/)
## Example Entry
| ID | design_name | sequence | structure | reactivity | errors | signal_to_noise |
| -------- | ---------------------- | ---------------- | ---------------- | -------------------------- | --------------------------- | --------------- |
| 769337-1 | d+m plots weaker again | GGAAAAAAAAAAA... | ................ | [0.642,1.4853,0.1629, ...] | [0.3181,0.4221,0.1823, ...] | 3.227 |
## Column Description
The EternaBench-Switch dataset consists of the following columns, providing crucial insights for understanding RNA stability for vaccine design:
- **ID**:
A unique identifier for each RNA sequence entry.
- **design_name**:
The name given to each RNA design by contributors, used for easy reference.
- **sequence**:
The nucleotide sequence of the RNA, using standard bases.
- **structure**:
The predicted secondary structure of the RNA, represented using dot-bracket notation.
The structure helps determine the likely secondary interactions within each RNA molecule.
- **reactivity**:
A list of floating-point values that provide an estimate of the likelihood of the RNA backbone being cut at each nucleotide position.
These values help determine the stability of the RNA structure under various experimental conditions.
- **errors**:
Arrays of floating-point numbers indicating the experimental errors corresponding to the measurements in the **reactivity**.
These values help quantify the uncertainty in the degradation rates and reactivity measurements.
## Related Datasets
- [EternaBench-CM](https://huggingface.co/datasets/multimolecule/eternabench-cm)
- [EternaBench-Switch](https://huggingface.co/datasets/multimolecule/eternabench-switch)
## License
This dataset is licensed under the [AGPL-3.0 License](https://www.gnu.org/licenses/agpl-3.0.html).
```spdx
SPDX-License-Identifier: AGPL-3.0-or-later
```
## Citation
```bibtex
@article{waymentsteele2022rna,
author = {Wayment-Steele, Hannah K and Kladwang, Wipapat and Strom, Alexandra I and Lee, Jeehyung and Treuille, Adrien and Becka, Alex and {Eterna Participants} and Das, Rhiju},
journal = {Nature Methods},
month = oct,
number = 10,
pages = {1234--1242},
publisher = {Springer Science and Business Media LLC},
title = {{RNA} secondary structure packages evaluated and improved by high-throughput experiments},
volume = 19,
year = 2022
}
```
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