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Shang Data Lab @UCSD 7

The method of claim 1 , further comprising coextruding a barrier layer comprising polar polymers on a surface of the core layer opposite the skin layer.

Utility

["428", "220000"]

2018-01

2018-06

Described are transparent oriented polypropylene films with improved barrier properties and methods of making these films. The films and methods include a core layer comprising polypropylene, hydrocarbon resin, and polyethylene wax to improve moisture vapor barrier properties, an optional barrier layer comprising polar polymers to improve oxygen barrier properties, and optional skin layers to improve heat sealing, winding, printing, and/or adhesion.

['14282450', '15083162', '12332153', '13030392', '14529750']

open

(15882745, 2)

test

A method of making a film comprising:\n coextruding a core layer comprising high crystalline polypropylene, hydrocarbon resin, and polyethylene wax with a skin layer comprising polyolefin.

Utility

["428", "220000"]

2018-01

2018-06

Described are transparent oriented polypropylene films with improved barrier properties and methods of making these films. The films and methods include a core layer comprising polypropylene, hydrocarbon resin, and polyethylene wax to improve moisture vapor barrier properties, an optional barrier layer comprising polar polymers to improve oxygen barrier properties, and optional skin layers to improve heat sealing, winding, printing, and/or adhesion.

['14282450', '15083162', '12332153', '13030392', '14529750']

open

(15882745, 1)

test

The paper sheet processing device according to claim 13 , wherein the paper sheet is a bill.

Utility

["194", "206000"]

2018-01

2018-07

A paper sheet processing device includes: an identification unit that identifies a paper sheet; a temporary holding unit that temporarily holds the identified paper sheet; and a linear transport path that connects the identification unit and the temporary holding unit, extends in a straight line, and transports the paper sheet identified by the identification unit to the temporary holding unit.

['11473059', '10751406', '12733630', '14009764', '12531007']

none

(15741849, 15)

test

The paper sheet processing device according to claim 13 , wherein a position of the identification unit in the vertical direction agrees with a position of the temporary holding unit in the vertical direction, and the linear transport path extends in a horizontal direction.

Utility

["194", "206000"]

2018-01

2018-07

A paper sheet processing device includes: an identification unit that identifies a paper sheet; a temporary holding unit that temporarily holds the identified paper sheet; and a linear transport path that connects the identification unit and the temporary holding unit, extends in a straight line, and transports the paper sheet identified by the identification unit to the temporary holding unit.

['11473059', '10751406', '12733630', '14009764', '12531007']

none

(15741849, 14)

test

A paper sheet processing device comprising:\n an input unit in which a paper sheet is input; an identification unit that identifies the paper sheet that has been input in the input unit; a temporary holding unit that temporarily holds the identified paper sheet; a linear transport path that connects the identification unit and the temporary holding unit, extends in a straight line, and transports the paper sheet identified by the identification unit to the temporary holding unit; and a first transportation path that is connected with the input unit, and transports the paper sheet that has been input in the input unit to the identification unit, wherein the first transportation path is provided downward toward rear from front toward rear of the paper sheet processing device.

Utility

["194", "206000"]

2018-01

2018-07

A paper sheet processing device includes: an identification unit that identifies a paper sheet; a temporary holding unit that temporarily holds the identified paper sheet; and a linear transport path that connects the identification unit and the temporary holding unit, extends in a straight line, and transports the paper sheet identified by the identification unit to the temporary holding unit.

['11473059', '10751406', '12733630', '14009764', '12531007']

open

(15741849, 13)

test

The paper sheet processing device according to claim 1 , wherein the paper sheet is a bill.

Utility

["194", "206000"]

2018-01

2018-07

A paper sheet processing device includes: an identification unit that identifies a paper sheet; a temporary holding unit that temporarily holds the identified paper sheet; and a linear transport path that connects the identification unit and the temporary holding unit, extends in a straight line, and transports the paper sheet identified by the identification unit to the temporary holding unit.

['11473059', '10751406', '12733630', '14009764', '12531007']

none

(15741849, 12)

test

The paper sheet processing device according to claim 1 , wherein a position of the identification unit in the vertical direction agrees with a position of the temporary holding unit in the vertical direction, and the linear transport path extends in a horizontal direction.

Utility

["194", "206000"]

2018-01

2018-07

A paper sheet processing device includes: an identification unit that identifies a paper sheet; a temporary holding unit that temporarily holds the identified paper sheet; and a linear transport path that connects the identification unit and the temporary holding unit, extends in a straight line, and transports the paper sheet identified by the identification unit to the temporary holding unit.

['11473059', '10751406', '12733630', '14009764', '12531007']

none

(15741849, 11)

test

The paper sheet processing device according to claim 9 , wherein each of the input unit and the payout unit is provided downward toward rear from front toward rear of the paper sheet processing device, positions of the input unit and the payout unit in the vertical direction agree with each other, and positions of the input unit and the payout unit in a horizontal direction agree with each other.

Utility

["194", "206000"]

2018-01

2018-07

A paper sheet processing device includes: an identification unit that identifies a paper sheet; a temporary holding unit that temporarily holds the identified paper sheet; and a linear transport path that connects the identification unit and the temporary holding unit, extends in a straight line, and transports the paper sheet identified by the identification unit to the temporary holding unit.

['11473059', '10751406', '12733630', '14009764', '12531007']

none

(15741849, 10)

test

The paper sheet processing device according to claim 1 , further comprising:\n an input unit in which a paper sheet is input; and a first transportation path that is connected with the input unit, and transports the paper sheet that has been input in the input unit to the identification unit, wherein the first transportation path is provided downward toward rear from front toward rear of the paper sheet processing device.

Utility

["194", "206000"]

2018-01

2018-07

A paper sheet processing device includes: an identification unit that identifies a paper sheet; a temporary holding unit that temporarily holds the identified paper sheet; and a linear transport path that connects the identification unit and the temporary holding unit, extends in a straight line, and transports the paper sheet identified by the identification unit to the temporary holding unit.

['11473059', '10751406', '12733630', '14009764', '12531007']

open

(15741849, 9)

test

A paper sheet processing device comprising:\n an identification unit that identifies a paper sheet; a temporary holding unit that temporarily holds the identified paper sheet; a linear transport path that connects the identification unit and the temporary holding unit, extends in a straight line, and transports the paper sheet identified by the identification unit to the temporary holding unit; a payout unit that makes the identified and temporarily held paper sheet be capable of being removed to an outside; and a dispensing transport path that branches upward from an intermediate position of the linear transport path, connected with the payout unit, and transports the identified and temporarily held paper sheet to the payout unit, wherein the payout unit, the identification unit, and the temporary holding unit are arranged horizontally in this order and are not overlapped with each other when seen from a vertical direction.

Utility

["194", "206000"]

2018-01

2018-07

A paper sheet processing device includes: an identification unit that identifies a paper sheet; a temporary holding unit that temporarily holds the identified paper sheet; and a linear transport path that connects the identification unit and the temporary holding unit, extends in a straight line, and transports the paper sheet identified by the identification unit to the temporary holding unit.

['11473059', '10751406', '12733630', '14009764', '12531007']

open

(15741849, 1)

test

The reinforcement steel according to claim 1 , wherein a bottom surface of the recess is formed to be curved.

Utility

["052", "851000"]

2018-01

2018-11

A reinforcement steel bar includes a shaft part and a head part formed by forging an end portion of the shaft part. The head part is provided with a projection projecting from the shaft part in a radial direction of the shaft part, and a recess formed along a corner portion between an outer peripheral surface of the shaft part and the projection.

['15122161', '14424470', '13190637', '14767901', '10721945']

none

(15882049, 2)

test

Reinforcement steel comprising:\n a shaft part; and a forged head part provided at an end portion of the shaft part, wherein the head part is provided with\n a projection projecting from the shaft part in a radial direction of the shaft part, and \n a recess formed along a corner portion between an outer peripheral surface of the shaft part and the projection, \n wherein a rib is formed on an outer peripheral surface of the shaft part.

Utility

["052", "851000"]

2018-01

2018-11

A reinforcement steel bar includes a shaft part and a head part formed by forging an end portion of the shaft part. The head part is provided with a projection projecting from the shaft part in a radial direction of the shaft part, and a recess formed along a corner portion between an outer peripheral surface of the shaft part and the projection.

['15122161', '14424470', '13190637', '14767901', '10721945']

open

(15882049, 1)

test

The method according to claim 104 , wherein (L) comprises the dipeptide Val-Cit.

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

none

(15872642, 107)

test

The method according to claim 104 , wherein (L) comprises a dipeptide.

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

none

(15872642, 106)

test

The method according to claim 104 , wherein the precursor comprises a protected amine group, step (i) comprises deprotecting the precursor to provide a compound of Formula I having a free amine group, and step (ii) comprises conjugating the compound of Formula I to (L) via the free amine group.

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

none

(15872642, 105)

test

A method of preparing an antibody drug conjugate of Formula II:\n (T)-(L)-(D)\u2003\u2003 II \n wherein (T) is a targeting moiety, (L) is a linker, and (D) is a compound of Formula I: wherein:\n R 1 is selected from: amino-C 1 -C 6 alkyl, amino-aryl, amino-C 3 -C 7 cycloalkyl, amino-heterocyclyl and heterocyclyl, each optionally substituted with one or more substituents selected from aryl, aryl-C 1 -C 6 alkyl, C 1 -C 6 alkyl, C 1 -C 6 alkylthio, carboxyl, carboxamide, C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl-C 1 -C 6 alkyl, guanidino, halo, C 1 -C 6 haloalkyl, heterocyclyl, heterocyclyl-C 1 -C 6 alkyl, hydroxyl and thio; or \n R 1 is R a R b NCH(R c )\u2014; \n R a is selected from: H and C 1 -C 6 alkyl; \n R b is C 1 -C 6 alkyl; \n R c is R d -C(CH 3 ) 2 \u2014; \n R d is selected from: H, aryl, C 3 -C 7 cycloalkyl and heteroaryl, each of which is optionally substituted with one or more substituents selected from: C 1 -C 4 acylthio, C 2 -C 4 alkenyl, C 1 -C 4 alkyl, C 1 -C 4 alkylamino, C 1 -C 4 alkyloxy, amino, amino-C 1 -C 4 alkyl, halo, C 1 -C 4 haloalkyl, hydroxyl, hydroxy-C 1 -C 4 alkyl and thio, wherein C 2 -C 4 alkenyl, C 1 -C 4 alkylamino and C 1 -C 4 alkyloxy are further optionally substituted with one substituent selected from C 1 -C 4 alkylaryl, hydroxyl and thio; or \n R b and R c taken together with the atoms to which they are each bonded form a heterocyclyldiyl; \n R 2 is selected from: C 2 -C 6 alkyl, aryl, aryl-C 1 -C 6 alkyl, C 4 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl-C 1 -C 6 alkyl, heteroaryl, heteroaryl-C 1 -C 6 alkyl and heterocyclyl, each optionally substituted with one or more substituents selected from: C 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 alkyl, C 1 -C 6 alkylamino, amino, amino-C 1 -C 6 alkyl, amino-aryl, amino-C 3 -C 7 cycloalkyl, aryl, carboxamide, carboxyl, cyano, C 1 -C 6 haloacyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, halo, hydroxyl, nitro, thio and thio-C 1 -C 6 alkyl, and \n X is absent, \n the method comprising:\n (i) deprotecting the precursor according to claim 74 to provide a compound of Formula I, \n (ii) conjugating the compound of Formula I to (L).

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

open

(15872642, 104)

test

A method of preparing the precursor according to claim 74 , comprising:\n (a) reacting a first intermediate having the following structure: wherein R 1 is as defined in claim 74 , with a second intermediate having the following structure: wherein R 2 is as defined in claim 74 , under conditions allowing formation of the precursor, wherein one of R 1 and R 2 comprises a protected amine group or a protected hydroxyl group; or\n (b) reacting an intermediate 5: \n wherein:\n R 2 is as defined in claim 74 , and \n PG is a protecting group, \n with N,N-dimethyl valine under conditions allowing formation of the precursor, wherein R 2 comprises a protected amine group or a protected hydroxyl group.

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

open

(15872642, 103)

test

A method of preparing a compound of Formula I: wherein:\n R 1 is selected from: amino-C 1 -C 6 alkyl, amino-aryl, amino-C 3 -C 7 cycloalkyl, amino-heterocyclyl and heterocyclyl, each optionally substituted with one or more substituents selected from aryl, aryl-C 1 -C 6 alkyl, C 1 -C 6 alkyl, C 1 -C 6 alkylthio, carboxyl, carboxamide, C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl-C 1 -C 6 alkyl, guanidino, halo, C 1 -C 6 haloalkyl, heterocyclyl, heterocyclyl-C 1 -C 6 alkyl, hydroxyl and thio; or \n R 1 is R a R b NCH(R c )\u2014; \n R a is selected from: H and C 1 -C 6 alkyl; \n R b is C 1 -C 6 alkyl; \n R c is R d -C(CH 3 ) 2 \u2014; \n R d is selected from: H, aryl, C 3 -C 7 cycloalkyl and heteroaryl, each of which is optionally substituted with one or more substituents selected from: C 1 -C 4 acylthio, C 2 -C 4 alkenyl, C 1 -C 4 alkyl, C 1 -C 4 alkylamino, C 1 -C 4 alkyloxy, amino, amino-C 1 -C 4 alkyl, halo, C 1 -C 4 haloalkyl, hydroxyl, hydroxy-C 1 -C 4 alkyl and thio, wherein C 2 -C 4 alkenyl, C 1 -C 4 alkylamino and C 1 -C 4 alkyloxy are further optionally substituted with one substituent selected from C 1 -C 4 alkylaryl, hydroxyl and thio; or \n R b and R c taken together with the atoms to which they are each bonded form a heterocyclyldiyl; \n R 2 is selected from: C 2 -C 6 alkyl, aryl, aryl-C 1 -C 6 alkyl, C 4 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl-C 1 -C 6 alkyl, heteroaryl, heteroaryl-C 1 -C 6 alkyl and heterocyclyl, each optionally substituted with one or more substituents selected from: C 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 alkyl, C 1 -C 6 alkylamino, amino, amino-C 1 -C 6 alkyl, amino-aryl, amino-C 3 -C 7 cycloalkyl, aryl, carboxamide, carboxyl, cyano, C 1 -C 6 haloacyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, halo, hydroxyl, nitro, thio and thio-C 1 -C 6 alkyl, and \n X is absent, \n the method comprising the step of deprotecting the precursor according to claim 74 .

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

open

(15872642, 102)

test

The precursor according to claim 74 , selected from:\n (a) (S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(4-(2,2,2-trifluoroacetamido)phenylsulfonamido)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethylbutanamide (Compound 4) (b) (S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-((4-(2,2,2-trifluoroacetamido)phenyl) methyl sulfonamido)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethylbutanamide (Compound 7) (c) (R)-1-isopropyl-N\u2014((S)-1-(((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-((4-(2,2,2-trifluoroacetamido)phenyl)sulfonamido)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)piperidine-2-carboxamide (Compound 15) (d) tert-butyl (1-(((S)-1-(((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-((4-(2,2,2-trifluoroacetamido)phenyl)sulfonamido)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-2-methyl-1-oxopropan-2-yl)carbamate (Compound 18) (e) (S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-((4-((2,2,2-trifluoroacetamido)methyl)phenyl)sulfonamido)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethylbutanamide (Compound 21) (f) (S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((4-((2,2,2-trifluoroacetamido)methyl)phenyl)methyl)sulfonamido)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N, 3-dimethylbutanamide (Compound 25) (g) (S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(4-(1-(2,2,2-trifluoroacetamido)cyclopropyl)phenylsulfonamido)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethylbutanamide (Compound 29)

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

none

(15872642, 101)

test

The precursor according to claim 99 , wherein the protecting group is a trihaloacetyl group.

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

none

(15872642, 100)

test

The precursor according to claim 98 , wherein the protecting group is selected from: 2-trimethylsilylethoxycarbonyl (Teoc), 1-methyl-1-(4-biphenylyl)ethoxycarbonyl (Bpoc), t-butoxycarbonyl (BOC), allyloxycarbonyl (Alloc), 9-fluorenylmethyloxycarbonyl (Fmoc), benzyloxycarbonyl (Cbz), formyl, acetyl, trihaloacetyl, benzoyl, nitrophenylacetyl, 2-nitrobenzenesulfonyl, phthalimido and dithiasuccinoyl.

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

none

(15872642, 99)

test

The precursor according to claim 97 , wherein the protected amine comprises a protecting group selected from: a carbamate protecting group, an amide protecting group, a sulfonamide protecting group, an imine protecting group and a cyclic imide protecting group.

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

none

(15872642, 98)

test

The precursor according to claim 94 , wherein R 2 is selected from: 4-aminobenzyl, 4-(aminomethyl)benzyl, 4-(aminomethyl)phenyl, 4-aminophenyl, 4-aminocarbonyl-2-nitrophenyl, 3-aminophenyl, 4-(1-aminocyclopropyl)benzyl, 4-(1-aminocyclopropyl)phenyl, 2-aminophenyl, 4\u2032-amino-[1,1\u2032-biphenyl]-4-yl, 4-amino-2-ethylphenyl, 4-amino-3-(trifluoromethoxy)phenyl, 4-amino-2,3-dimethylphenyl, 4-amino-5,6,7,8-tetrahydronaphthalen-1-yl, 4-amino-3-methylphenyl, 4-amino-3-fluorophenyl, 4-amino-3-ethylphenyl and 4-amino-3-(trifluoromethyl)phenyl.

Utility

["548", "400000"]

2018-01

2018-07

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

['14857733', '15512030', '15108258', '14213504', '14776654']

none

(15872642, 96)

test

A method of controlling a lithographic apparatus to manufacture a plurality of devices on a substrate, the method comprising:\n obtaining a height map representing a topographical variation across the substrate; and using the height map to control a positioning system of the lithographic apparatus for applying a device pattern at multiple locations across the substrate, wherein using the height map comprises:\n subtracting from the height map a first height map component representing topographical variations associated with the device pattern so as to obtain a second height map component representing other topographical variations; \n using the obtained second height map component, calculating control set-points according to a control algorithm specific to the other topographical variations; and \n using the calculated set-points to control the positioning system to apply the device pattern to the substrate.

Utility

["355", "067000"]

2018-01

2018-07

A lithographic apparatus applies a device pattern at multiple fields across a substrate. A height map is decomposed into a plurality of components. A first height map component represents topographical variations associated with the device pattern. One or more further height map components represent other topographical variations. Using each height map component, control set-points are calculated according to a control algorithm specific to each component. The control set-points calculated for the different height map components are then combined and used to control imaging of the device pattern to the substrate. The specific control algorithms can be different from one another, and may have differing degrees of nonlinearity. The combining of the different set-points can be linear. Focus control in the presence of device-specific topography and other local variations can be improved.

['15752658', '15736142', '15121340', '16076743', '11588281']

open

(15743661, 13)

test

An apparatus comprising a data processing apparatus programmed to at least:\n receive a height map of a substrate that has been subjected to lithographic processing over a plurality of device areas; subtract from the height map a first height map component representing topographical variations associated with the device pattern so as to obtain a second height map component representing other topographical variations; using the obtained second height map component, calculate control set-points according to a control algorithm specific to the other topographical variations; combine the control set-points calculated for the first height map component and the second height map component; and provide set-points to control a positioning system of a lithographic apparatus configured to apply a device pattern at multiple substrate locations, to apply the device pattern to the substrate.

Utility

["355", "067000"]

2018-01

2018-07

A lithographic apparatus applies a device pattern at multiple fields across a substrate. A height map is decomposed into a plurality of components. A first height map component represents topographical variations associated with the device pattern. One or more further height map components represent other topographical variations. Using each height map component, control set-points are calculated according to a control algorithm specific to each component. The control set-points calculated for the different height map components are then combined and used to control imaging of the device pattern to the substrate. The specific control algorithms can be different from one another, and may have differing degrees of nonlinearity. The combining of the different set-points can be linear. Focus control in the presence of device-specific topography and other local variations can be improved.

['15752658', '15736142', '15121340', '16076743', '11588281']

open

(15743661, 14)

test

A non-transitory computer program product comprising machine readable instructions for causing a general purpose data processing apparatus to at least:\n obtain a height map representing a topographical variation across a substrate; and use the height map to control a positioning system of a lithographic apparatus for applying a device pattern at multiple locations across the substrate, wherein use of the height map comprises: (a) decomposition of the height map into a plurality of components, including a first height map component representing topographical variations associated with the device pattern and a second height map component representing other topographical variations, calculation of control set-points according to a control algorithm specific to each of the first and second height map components, combination of the control set-points calculated for the first height map component and the second height map component, and use of the combined set-points to control the positioning system to apply the device pattern to the substrate, or (b) subtraction from the height map a first height map component representing topographical variations associated with the device pattern so as to obtain a second height map component representing other topographical variations, calculation of control set-points, using the obtained second height map component, according to a control algorithm specific to the other topographical variations, and use of the calculated set-points to control the positioning system to apply the device pattern to the substrate.

Utility

["355", "067000"]

2018-01

2018-07

A lithographic apparatus applies a device pattern at multiple fields across a substrate. A height map is decomposed into a plurality of components. A first height map component represents topographical variations associated with the device pattern. One or more further height map components represent other topographical variations. Using each height map component, control set-points are calculated according to a control algorithm specific to each component. The control set-points calculated for the different height map components are then combined and used to control imaging of the device pattern to the substrate. The specific control algorithms can be different from one another, and may have differing degrees of nonlinearity. The combining of the different set-points can be linear. Focus control in the presence of device-specific topography and other local variations can be improved.

['15752658', '15736142', '15121340', '16076743', '11588281']

open

(15743661, 15)

test

The audio device according to claim 3 , wherein\n when the time stamp is earlier than the end time of the pulse data, the processor is configured to (i) adjust the audio data by cutting the audio data for an amount corresponding to a difference between the time stamp and the end of the pulse data, and (ii) output the adjusted audio data.

Utility

["700", "090000"]

2018-01

2019-07

An audio device, which is configured to receive audio data from another device, comprises a memory that stores instructions and a processor. The processor is configured to execute the instructions stored in the memory to: receive the audio data and a time stamp attached to the audio data, output a pulse data having a predetermined length, detect end time of the pulse data, compare the end time of the pulse data and the time stamp, adjust the audio data based on the comparing result, and output the adjusted audio data.

['13204079', '11053904', '14023815', '11691688', '15841756']

none

(15871820, 4)

test

The audio device according to claim 1 , wherein\n the memory stores silent audio data, and when the time stamp is later than the end time of the pulse data, the processor is configured to (i) output the silent audio data for a period corresponding to a difference between the time stamp and the end time of the pulse data, and (ii) output the audio data after the silent audio data is output.

Utility

["700", "090000"]

2018-01

2019-07

An audio device, which is configured to receive audio data from another device, comprises a memory that stores instructions and a processor. The processor is configured to execute the instructions stored in the memory to: receive the audio data and a time stamp attached to the audio data, output a pulse data having a predetermined length, detect end time of the pulse data, compare the end time of the pulse data and the time stamp, adjust the audio data based on the comparing result, and output the adjusted audio data.

['13204079', '11053904', '14023815', '11691688', '15841756']

none

(15871820, 3)

test

The audio device according to claim 1 , wherein\n the processor is configured to (i) detect the start time of the pulse data, where an amplitude of the pulse data increases by a predetermined value and (ii) detect the end time of the pulse data based on the predetermined length and the start time.

Utility

["700", "090000"]

2018-01

2019-07

An audio device, which is configured to receive audio data from another device, comprises a memory that stores instructions and a processor. The processor is configured to execute the instructions stored in the memory to: receive the audio data and a time stamp attached to the audio data, output a pulse data having a predetermined length, detect end time of the pulse data, compare the end time of the pulse data and the time stamp, adjust the audio data based on the comparing result, and output the adjusted audio data.

['13204079', '11053904', '14023815', '11691688', '15841756']

none

(15871820, 2)

test

An audio device which is configured to wirelessly receive audio data from another audio device, comprising:\n a memory which stores instructions and pulse data having a starting point and a predetermined length, a clock which outputs an audio clock that indicates a timing of playback of the audio data, and a processor that is configured to execute the instructions stored in the memory to: wirelessly receive the audio data and a time stamp attached to the audio data from the other audio device, output the pulse data having the starting point and the predetermined length in the audio device, the pulse data being output when the audio device receives the audio data, detect start time of the pulse data based on the starting point by referring to the clock and end time of the pulse data by referring to the predetermined length and the start time, compare the end time of the pulse data and the time stamp, adjust the audio clock based on the comparing result, thereby adjusting the audio data, and output the adjusted audio data synchronized with the other audio device, the adjusted audio data being output after the pulse data is output.

Utility

["700", "090000"]

2018-01

2019-07

An audio device, which is configured to receive audio data from another device, comprises a memory that stores instructions and a processor. The processor is configured to execute the instructions stored in the memory to: receive the audio data and a time stamp attached to the audio data, output a pulse data having a predetermined length, detect end time of the pulse data, compare the end time of the pulse data and the time stamp, adjust the audio data based on the comparing result, and output the adjusted audio data.

['13204079', '11053904', '14023815', '11691688', '15841756']

open

(15871820, 1)

test

The bone anchoring device of claim 20 , wherein when the pressure element is at the pre-locking position, the head is frictionally clamped in the pressure element, such that an angular position of the receiving part relative to the bone anchoring element remains adjustable upon exertion of a force on the bone anchoring element and/or the receiving part that is greater than the frictional clamping force applied on the head and greater than a force for adjusting the angular position of the receiving part relative to the bone anchoring element when the pressure element is at at least one position different than the pre-locking position.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

none

(15872428, 24)

test

The method of claim 21 , further comprising introducing the head through the opening into the pressure element prior to inserting the bone anchoring element into the bone.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

open

(15872428, 23)

test

The method of claim 21 , further comprising introducing the head through the opening into the pressure element after inserting the bone anchoring element into the bone.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

open

(15872428, 22)

test

A method for coupling a rod to a bone via a bone anchoring element and a receiving part, the receiving part comprising a receiving part body having a first end, a second end below the first end, a substantially U-shaped recess at the first end forming a channel for receiving the rod, an accommodation space for accommodating a head of the bone anchoring element, and an opening at the second end for inserting the head into the accommodation space, and a pressure element configured to be arranged at least partially in the accommodation space, the pressure element comprising a first section configured to contact the rod when the pressure element is in the receiving part, and a second section axially connected to the first section and having an expandable portion configured to accommodate and clamp the head, wherein the pressure element is insertable upwards through the opening at the second end of the receiving part body into the accommodation space, and a closure element, the method comprising:\n inserting the bone anchoring element into a bone; adjusting an angular position of the receiving part relative to the bone anchoring element when the head is held in the expandable portion of the pressure element and the pressure element is in the receiving part body at a pre-locking position, wherein an abutment at an inner wall of the receiving part body holds the pressure element against movement towards the first end of the receiving part body, while the inner wall of the receiving part body further prevents removal of the head from the receiving part; inserting the rod into the channel; and advancing the closure element in the substantially U-shaped recess towards the second end of the receiving part body, the closure element advancing the rod towards the second end, the rod advancing the pressure element towards the second end; wherein the closure element is advanced until the closure element locks the relative positions of the rod and the bone anchoring element with respect to the receiving part.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

open

(15872428, 21)

test

A bone anchoring device comprising:\n a bone anchoring element comprising a shaft and a head; a receiving part for receiving a rod for coupling the rod to the bone anchoring element, the receiving part comprising:\n a receiving part body having a first end, a second end below the first end, a substantially U-shaped recess at the first end forming a channel for receiving the rod, an accommodation space for accommodating the head of the bone anchoring element, and an opening at the second end for inserting the head into the accommodation space; and \n a pressure element configured to be arranged at least partially in the accommodation space, the pressure element comprising a first section configured to contact the rod when the pressure element is in the receiving part, and a second section axially connected to the first section and having an expandable portion configured to accommodate and clamp the head; \n wherein the pressure element is insertable upwards through the opening at the second end of the receiving part body into the accommodation space; and wherein when the pressure element is in the receiving part body and the head is held in the expandable portion of the pressure element, the pressure element is configured to assume a pre-locking position wherein an abutment at an inner wall of the receiving part body holds the pressure element against movement towards the first end of the receiving part body, while the inner wall of the receiving part body further prevents removal of the head from the receiving part.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

open

(15872428, 20)

test

The receiving part of claim 16 , wherein the expandable portion has a diameter larger than a diameter of the hollow cylindrically shaped portion.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

none

(15872428, 19)

test

The audio device according to claim 1 , further comprising:\n an additional processor that is configured to detect start time of the pulse data based on the starting point, where an amplitude of the pulse data increases by a predetermined value; wherein the additional processor is formed separately from the processor, and the processor is configured to (i) read out the start time of the pulse data from the additional processor, and (ii) detect the end time of the pulse data based on the predetermined length and the start time.

Utility

["700", "090000"]

2018-01

2019-07

An audio device, which is configured to receive audio data from another device, comprises a memory that stores instructions and a processor. The processor is configured to execute the instructions stored in the memory to: receive the audio data and a time stamp attached to the audio data, output a pulse data having a predetermined length, detect end time of the pulse data, compare the end time of the pulse data and the time stamp, adjust the audio data based on the comparing result, and output the adjusted audio data.

['13204079', '11053904', '14023815', '11691688', '15841756']

open

(15871820, 5)

test

The receiving part of claim 16 , wherein the accommodation space has a larger diameter than a diameter of the hollow cylindrically shaped portion.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

none

(15872428, 18)

test

The receiving part of claim 1 , wherein the receiving part body has a bore extending between the first and second ends, the bore including a hollow cylindrically shaped portion, and wherein the accommodation space is positioned between the opening and the hollow cylindrically shaped portion.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

none

(15872428, 16)

test

The receiving part of claim 1 , further comprising a closure element, wherein the receiving part body has a bore extending between the first and second ends, and a thread at the first end for engagement with the closure element for fixing the rod in the channel.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

open

(15872428, 15)

test

The receiving part according to claim 1 , wherein the expandable portion of the pressure element has a plurality of slits extending from a free end of the second section towards the first section.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

none

(15872428, 12)

test

The receiving part of claim 7 , wherein the narrowing portion of the receiving part body comprises two adjacent curved portions forming a groove therebetween, and the corresponding portion of the pressure element comprises two corresponding adjacent curved portions forming an inner crest therebetween and further comprising an edge crest along an outer edge of one of the two corresponding adjacent curved portions, wherein the edge crest is configured to snap into the groove in a first locking position of the pressure element, and the inner crest is configured to snap into the groove in a second locking position of the pressure element.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

open

(15872428, 11)

test

The receiving part of claim 8 , wherein the other one of the narrowing portion of the receiving part body or the corresponding portion of the pressure element is curved.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

none

(15872428, 10)

test

The receiving part of claim 8 , wherein both the narrowing portion of the receiving part body and the corresponding portion of the pressure element are tapered.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

none

(15872428, 9)

test

The receiving part of claim 7 , wherein at least one of the narrowing portion of the receiving part body or the corresponding portion of the pressure element is tapered.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

none

(15872428, 8)

test

The receiving part of claim 1 , wherein the receiving part body comprises a narrowing portion near the opening, the narrowing portion configured to cooperate with a corresponding portion of the pressure element to clamp the head.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']

none

(15872428, 7)

test

The receiving part of claim 1 , wherein in an insertion position that is different from the pre-locking position, the pressure element is positioned in the receiving part body such that a space between an outer wall of the expandable portion and an inner wall of the accommodation space provides for widening of the expandable portion for inserting the head.

Utility

["606", "266000"]

2018-01

2018-05

A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including a first end and a second end, and having a substantially U-shaped recess at the first end forming a channel for receiving the rod, and an accommodation space for accommodating a head of the bone anchoring element, the accommodation space having an opening at the second end for introducing the head; and a pressure element arranged at least partially in the accommodation space, the pressure element including a first section having a second recess for receiving the rod, and a second section having a flexible portion to clamp the head, the first section and the second section being fixed relative to each other, wherein said pressure element is insertable from the opening.

['12855395', '14878809', '14517624', '15156274', '12709375']