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In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The positive control for DMT1 up - regulation was a murine model of dietary iron deficiency that demonstrated greatly increased levels of duodenal DMT1 ( IRE ) mRNA .
### Output Text: | The positive control for DMT1 up - regulation was a murine model of <span class="disease">dietary iron deficiency</span> that demonstrated greatly increased levels of duodenal DMT1 ( IRE ) mRNA . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: HFE - / - mice also demonstrated an increase in duodenal DMT1 ( IRE ) mRNA ( average 7 . 7 - fold ) , despite their elevated transferrin saturation and hepatic iron content .
### Output Text: | HFE - / - mice also demonstrated an increase in duodenal DMT1 ( IRE ) mRNA ( average 7 . 7 - fold ) , despite their elevated transferrin saturation and hepatic iron content . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Duodenal expression of DMT1 ( non - IRE ) was not increased , nor was hepatic expression of DMT1 increased .
### Output Text: | Duodenal expression of DMT1 ( non - IRE ) was not increased , nor was hepatic expression of DMT1 increased . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: These data support the model for HH in which HFE mutations lead to inappropriately low crypt cell iron , with resultant stabilization of DMT1 ( IRE ) mRNA , up - regulation of DMT1 , and increased absorption of dietary iron .
### Output Text: | These data support the model for HH in which HFE mutations lead to inappropriately low crypt cell iron , with resultant stabilization of DMT1 ( IRE ) mRNA , up - regulation of DMT1 , and increased absorption of dietary iron . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Neurophysiologic follow - up of long - term dietary treatment in adult - onset adrenoleukodystrophy .
### Output Text: | Neurophysiologic follow - up of long - term dietary treatment in adult - onset <span class="disease">adrenoleukodystrophy</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: OBJECTIVE To monitor the effects of dietary treatment in adult - onset adrenoleukodystrophy ( ALD ) by means of somatosensory evoked potentials ( SEPs ) and motor evoked potentials ( MEPs ) .
### Output Text: | OBJECTIVE To monitor the effects of dietary treatment in adult - onset <span class="disease">adrenoleukodystrophy</span> ( <span class="disease">ALD</span> ) by means of somatosensory evoked potentials ( SEPs ) and motor evoked potentials ( MEPs ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: BACKGROUND SEPs and MEPs have proved useful in revealing signs of progressively severe , central dying - back axonopathy in early stages of adult - onset ALD .
### Output Text: | BACKGROUND SEPs and MEPs have proved useful in revealing signs of progressively severe , central <span class="disease">dying - back axonopathy</span> in early stages of adult - onset <span class="disease">ALD</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: METHODS Eight patients with adult - onset ALD underwent clinical examination , brain and spine MRI , and SEP and MEP studies before and after 3 years of Lorenzos oil dietary therapy .
### Output Text: | METHODS Eight patients with adult - onset <span class="disease">ALD</span> underwent clinical examination , brain and spine MRI , and SEP and MEP studies before and after 3 years of Lorenzos oil dietary therapy . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: RESULTS Before treatment , brain MRI was normal in five patients .
### Output Text: | RESULTS Before treatment , brain MRI was normal in five patients . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Three of these patients had pure spinal SEP abnormalities and in the remaining two patients SEPs showed signs of involvement of both the spinal and cerebral somatosensory tracts .
### Output Text: | Three of these patients had pure <span class="disease">spinal SEP abnormalities</span> and in the remaining two patients SEPs showed signs of involvement of both the spinal and cerebral somatosensory tracts . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: After treatment , the three patients with pure spinal abnormalities showed clinical and neurophysiologic worsening , whereas the two patients with a more advanced stage of disease ( exhibited by SEPs ) showed substantially unchanged clinical and neurophysiologic features .
### Output Text: | After treatment , the three patients with pure <span class="disease">spinal abnormalities</span> showed clinical and neurophysiologic worsening , whereas the two patients with a more advanced stage of disease ( exhibited by SEPs ) showed substantially unchanged clinical and neurophysiologic features . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The patients with abnormal brain MRI at the onset of treatment showed clinical and neurophysiologic worsening .
### Output Text: | The patients with abnormal brain MRI at the onset of treatment showed clinical and neurophysiologic worsening . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: CONCLUSIONS Lorenzos oil therapy had no effect on patients with evidence of inflammatory brain lesions .
### Output Text: | CONCLUSIONS Lorenzos oil therapy had no effect on patients with evidence of <span class="disease">inflammatory brain lesions</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Moreover , in patients without clear signs of inflammatory damage , this treatment does not modify significantly the natural course of the disease .
### Output Text: | Moreover , in patients without clear signs of inflammatory damage , this treatment does not modify significantly the natural course of the disease . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: However , because effective treatments should begin before the onset of severe neurologic symptoms , SEPs and MEPs should be considered to evaluate the effectiveness of other experimental treatments in the patient with a negative brain MRI .
### Output Text: | However , because effective treatments should begin before the onset of severe neurologic symptoms , SEPs and MEPs should be considered to evaluate the effectiveness of other experimental treatments in the patient with a negative brain MRI . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: GCH1 mutation in a patient with adult - onset oromandibular dystonia .
### Output Text: | GCH1 mutation in a patient with adult - onset <span class="disease">oromandibular dystonia</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The authors report a mutation in exon 5 of GCH1 in a patient with adult - onset oromandibular dystonia and no obvious family history of dystonia .
### Output Text: | The authors report a mutation in exon 5 of GCH1 in a patient with adult - onset <span class="disease">oromandibular dystonia</span> and no obvious family history of <span class="disease">dystonia</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The patient responded positively to treatment with L - dopa .
### Output Text: | The patient responded positively to treatment with L - dopa . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: These findings demonstrate that GCH1 mutations must be considered even in patients with dystonic symptoms not typical of dopa - responsive dystonia .
### Output Text: | These findings demonstrate that GCH1 mutations must be considered even in patients with <span class="disease">dystonic</span> symptoms not typical of <span class="disease">dopa - responsive dystonia</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Germline mutations of the APC gene in Korean familial adenomatous polyposis patients .
### Output Text: | Germline mutations of the <span class="disease">APC</span> gene in Korean <span class="disease">familial adenomatous polyposis</span> patients . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: We extensively analyzed genomic DNA and messenger RNA ( mRNA ) from 62 unrelated Korean patients with familial adenomatous polyposis ( FAP ) for identification of germline adenomatous polyposis coli ( APC ) gene mutations .
### Output Text: | We extensively analyzed genomic DNA and messenger RNA ( mRNA ) from 62 unrelated Korean patients with <span class="disease">familial adenomatous polyposis</span> ( <span class="disease">FAP</span> ) for identification of germline <span class="disease">adenomatous polyposis coli</span> ( <span class="disease">APC</span> ) gene mutations . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: We adopted both single - strand conformation polymorphism ( SSCP ) analysis and a method of analysis involving the reverse transcription - polymerase chain reaction ( RT - PCR ) followed by a protein truncation test ( PTT ) .
### Output Text: | We adopted both single - strand conformation polymorphism ( SSCP ) analysis and a method of analysis involving the reverse transcription - polymerase chain reaction ( RT - PCR ) followed by a protein truncation test ( PTT ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: DNA sequencing confirmed all alterations represented by aberrant bands .
### Output Text: | DNA sequencing confirmed all alterations represented by aberrant bands . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Germline mutations were identified in 38 patients ( 61 % ) .
### Output Text: | Germline mutations were identified in 38 patients ( 61 % ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Nineteen of the detected mutations were presumed to be novel , thus emphasizing the heterogeneity of the mutational spectrum in Korean FAP patients .
### Output Text: | Nineteen of the detected mutations were presumed to be novel , thus emphasizing the heterogeneity of the mutational spectrum in Korean <span class="disease">FAP</span> patients . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: In the initial 48 patients , SSCP analysis was followed by PTT for those patients for whom no detectable mutations were found by SSCP .
### Output Text: | In the initial 48 patients , SSCP analysis was followed by PTT for those patients for whom no detectable mutations were found by SSCP . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Using this combined approach , we identified germline APC gene mutations in 29 of the 48 FAP patients ( 60 % ) , including 6 patients in whom SSCP analysis failed to distinguish the mutant allele .
### Output Text: | Using this combined approach , we identified germline <span class="disease">APC</span> gene mutations in 29 of the 48 <span class="disease">FAP</span> patients ( 60 % ) , including 6 patients in whom SSCP analysis failed to distinguish the mutant allele . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: In the 14 later patients , we identified truncating mutations in 9 patients ( 64 % ) using PTT only .
### Output Text: | In the 14 later patients , we identified truncating mutations in 9 patients ( 64 % ) using PTT only . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Our results confirm that the mutation detection rate with PTT was superior to that with SSCP , and suggest that PTT would be a more practical screening method to detect germline mutations of the APC gene in FAP patients .
### Output Text: | Our results confirm that the mutation detection rate with PTT was superior to that with SSCP , and suggest that PTT would be a more practical screening method to detect germline mutations of the <span class="disease">APC</span> gene in <span class="disease">FAP</span> patients . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Molecular epidemiology of C9 deficiency heterozygotes with an Arg95Stop mutation of the C9 gene in Japan .
### Output Text: | Molecular epidemiology of <span class="disease">C9 deficiency</span> heterozygotes with an Arg95Stop mutation of the C9 gene in Japan . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Deficiency of the ninth component of human complement ( C9 ) is the most common complement deficiency in Japan , with an incidence of approximately one homozygote in 1000 , but is very rare in other countries .
### Output Text: | <span class="disease">Deficiency of the ninth component of human complement</span> ( C9 ) is the most common <span class="disease">complement deficiency</span> in Japan , with an incidence of approximately one homozygote in 1000 , but is very rare in other countries . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Genetic analyses of Japanese C9 deficiency have shown that a C - to - T transition leading to TGA stop codon for Arg95 in exon 4 of the C9 gene ( Arg95Stop ) is common in Japanese C9 deficiency .
### Output Text: | Genetic analyses of Japanese <span class="disease">C9 deficiency</span> have shown that a C - to - T transition leading to TGA stop codon for Arg95 in exon 4 of the C9 gene ( Arg95Stop ) is common in Japanese <span class="disease">C9 deficiency</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: To determine the prevalence of heterozygous carriers of the Arg95Stop mutation in a Japanese population , we collected DNA samples from 300 individuals in two of the four main islands of Japan .
### Output Text: | To determine the prevalence of heterozygous carriers of the Arg95Stop mutation in a Japanese population , we collected DNA samples from 300 individuals in two of the four main islands of Japan . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Heterozygote detection was performed with an allele - specific polymerase chain reaction ( PCR ) system designed to detect exclusively only one of the normal and mutant alleles , followed by confirmation with PCR / single - strand conformation polymorphism ( SSCP ) analysis and direct sequencing .
### Output Text: | Heterozygote detection was performed with an allele - specific polymerase chain reaction ( PCR ) system designed to detect exclusively only one of the normal and mutant alleles , followed by confirmation with PCR / single - strand conformation polymorphism ( SSCP ) analysis and direct sequencing . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Twenty individuals were heterozygous for the Arg95Stop mutation .
### Output Text: | Twenty individuals were heterozygous for the Arg95Stop mutation . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: None was homozygous .
### Output Text: | None was homozygous . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The prevalence of carriers of the Arg95Stop mutation was 6 .
### Output Text: | The prevalence of carriers of the Arg95Stop mutation was 6 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: 7 % ( 20 / 300 ) .
### Output Text: | 7 % ( 20 / 300 ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: An estimated frequency ( 0 . 12 % ) of complete C9 deficiency due to homozygous Arg95Stop mutation was consistent with frequencies determined by serological studies
### Output Text: | An estimated frequency ( 0 . 12 % ) of complete <span class="disease">C9 deficiency</span> due to homozygous Arg95Stop mutation was consistent with frequencies determined by serological studies |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The hereditary hemochromatosis protein , HFE , specifically regulates transferrin - mediated iron uptake in HeLa cells .
### Output Text: | The <span class="disease">hereditary hemochromatosis</span> protein , HFE , specifically regulates transferrin - mediated iron uptake in HeLa cells . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis ( Feder , J .
### Output Text: | HFE is the protein product of the gene mutated in the <span class="disease">autosomal recessive disease</span> <span class="disease">hereditary hemochromatosis</span> ( Feder , J . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: N . , Gnirke , A . , Thomas , W . , Tsuchihashi , Z . , Ruddy , D .
### Output Text: | N . , Gnirke , A . , Thomas , W . , Tsuchihashi , Z . , Ruddy , D . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: A . , Basava , A . , Dormishian , F . , Domingo , R .
### Output Text: | A . , Basava , A . , Dormishian , F . , Domingo , R . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: J . , Ellis , M .
### Output Text: | J . , Ellis , M . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: C . , Fullan , A . , Hinton , L .
### Output Text: | C . , Fullan , A . , Hinton , L . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: M . , Jones , N .
### Output Text: | M . , Jones , N . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: L . , Kimmel , B .
### Output Text: | L . , Kimmel , B . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: E . , Kronmal , G .
### Output Text: | E . , Kronmal , G . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: S . , Lauer , P . , Lee , V .
### Output Text: | S . , Lauer , P . , Lee , V . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: K . , Loeb , D .
### Output Text: | K . , Loeb , D . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: B . , Mapa , F .
### Output Text: | B . , Mapa , F . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: A . , McClelland , E . , Meyer , N .
### Output Text: | A . , McClelland , E . , Meyer , N . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: C . , Mintier , G .
### Output Text: | C . , Mintier , G . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: A . , Moeller , N . , Moore , T . , Morikang , E . , Prasss , C .
### Output Text: | A . , Moeller , N . , Moore , T . , Morikang , E . , Prasss , C . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: E . , Quintana , L . , Starnes , S .
### Output Text: | E . , Quintana , L . , Starnes , S . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: M . , Schatzman , R .
### Output Text: | M . , Schatzman , R . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: C . , Brunke , K .
### Output Text: | C . , Brunke , K . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: J . , Drayna , D .
### Output Text: | J . , Drayna , D . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: T . , Risch , N .
### Output Text: | T . , Risch , N . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: J . , Bacon , B .
### Output Text: | J . , Bacon , B . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: R . , and Wolff , R .
### Output Text: | R . , and Wolff , R . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: R .
### Output Text: | R . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: ( 1996 ) Nat .
### Output Text: | ( 1996 ) Nat . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Genet .
### Output Text: | Genet . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: 13 , 399 - 408 ) .
### Output Text: | 13 , 399 - 408 ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: At the cell surface , HFE complexes with transferrin receptor ( TfR ) , increasing the dissociation constant of transferrin ( Tf ) for its receptor 10 - fold ( Gross , C .
### Output Text: | At the cell surface , HFE complexes with transferrin receptor ( TfR ) , increasing the dissociation constant of transferrin ( Tf ) for its receptor 10 - fold ( Gross , C . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: N . , Irrinki , A . , Feder , J . N . , and Enns , C . A . ( 1998 ) J . Biol . Chem . 273 , 22068 - 22074 ; Feder , J . N . , Penny , D . M . , Irrinki , A . , Lee , V . K . , Lebron , J . A . , Watson , N . , Tsuchihashi , Z . , Sigal , E . , Bjorkman , P . J . , and Schatzman , R . C . ( 1998 ) Proc . Natl .
### Output Text: | N . , Irrinki , A . , Feder , J . N . , and Enns , C . A . ( 1998 ) J . Biol . Chem . 273 , 22068 - 22074 ; Feder , J . N . , Penny , D . M . , Irrinki , A . , Lee , V . K . , Lebron , J . A . , Watson , N . , Tsuchihashi , Z . , Sigal , E . , Bjorkman , P . J . , and Schatzman , R . C . ( 1998 ) Proc . Natl . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Acad .
### Output Text: | Acad . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Sci .
### Output Text: | Sci . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: U S A 95 , 1472 - 1477 ) .
### Output Text: | U S A 95 , 1472 - 1477 ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: HFE does not remain at the cell surface , but traffics with TfR to Tf - positive internal compartments ( Gross et al . , 1998 ) .
### Output Text: | HFE does not remain at the cell surface , but traffics with TfR to Tf - positive internal compartments ( Gross et al . , 1998 ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Using a HeLa cell line in which the expression of HFE is controlled by tetracycline , we show that the expression of HFE reduces 55Fe uptake from Tf by 33 % but does not affect the endocytic or exocytic rates of TfR cycling .
### Output Text: | Using a HeLa cell line in which the expression of HFE is controlled by tetracycline , we show that the expression of HFE reduces 55Fe uptake from Tf by 33 % but does not affect the endocytic or exocytic rates of TfR cycling . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Therefore , HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments .
### Output Text: | Therefore , HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: HFE specifically reduces iron uptake from Tf , as non - Tf - mediated iron uptake from Fe - nitrilotriacetic acid is not altered .
### Output Text: | HFE specifically reduces iron uptake from Tf , as non - Tf - mediated iron uptake from Fe - nitrilotriacetic acid is not altered . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf - mediated pathway of iron uptake .
### Output Text: | These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf - mediated pathway of iron uptake . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver , pancreas , heart , and spleen that are iron loaded in hereditary hemochromatotic individuals lacking functional HFE .
### Output Text: | These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver , pancreas , heart , and spleen that are iron loaded in <span class="disease">hereditary hemochromatotic</span> individuals lacking functional HFE . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population .
### Output Text: | Mutation and haplotype studies of <span class="disease">familial Mediterranean fever</span> reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Familial Mediterranean fever ( FMF ) is a recessive disorder characterized by episodes of fever with serositis or synovitis .
### Output Text: | <span class="disease">Familial Mediterranean fever</span> ( <span class="disease">FMF</span> ) is a <span class="disease">recessive disorder</span> characterized by episodes of fever with <span class="disease">serositis</span> or <span class="disease">synovitis</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The FMF gene ( MEFV ) was cloned recently , and four missense mutations were identified .
### Output Text: | The <span class="disease">FMF</span> gene ( MEFV ) was cloned recently , and four missense mutations were identified . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Here we present data from non - Ashkenazi Jewish and Arab patients in whom we had not originally found mutations and from a new , more ethnically diverse panel .
### Output Text: | Here we present data from non - Ashkenazi Jewish and Arab patients in whom we had not originally found mutations and from a new , more ethnically diverse panel . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Among 90 symptomatic mutation - positive individuals , 11 mutations accounted for 79 % of carrier chromosomes .
### Output Text: | Among 90 symptomatic mutation - positive individuals , 11 mutations accounted for 79 % of carrier chromosomes . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Of the two mutations that are novel , one alters the same residue ( 680 ) as a previously known mutation , and the other ( P369S ) is located in exon 3 .
### Output Text: | Of the two mutations that are novel , one alters the same residue ( 680 ) as a previously known mutation , and the other ( P369S ) is located in exon 3 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Consistent with another recent report , the E148Q mutation was observed in patients of several ethnicities and on multiple microsatellite haplotypes , but haplotype data indicate an ancestral relationships between non - Jewish Italian and Ashkenazi Jewish patients with FMF and other affected populations .
### Output Text: | Consistent with another recent report , the E148Q mutation was observed in patients of several ethnicities and on multiple microsatellite haplotypes , but haplotype data indicate an ancestral relationships between non - Jewish Italian and Ashkenazi Jewish patients with <span class="disease">FMF</span> and other affected populations . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Among approximately 200 anonymous Ashkenazi Jewish DNA samples , the MEFV carrier frequency was 21 % , with E148Q the most common mutation .
### Output Text: | Among approximately 200 anonymous Ashkenazi Jewish DNA samples , the MEFV carrier frequency was 21 % , with E148Q the most common mutation . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Several lines of evidence indicate reduced penetrance among Ashkenazi Jews , especially for E148Q , P369S , and K695R .
### Output Text: | Several lines of evidence indicate reduced penetrance among Ashkenazi Jews , especially for E148Q , P369S , and K695R . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Nevertheless , E148Q helps account for recessive inheritance in an Ashkenazi family previously reported as an unusual case of dominantly inherited FMF .
### Output Text: | Nevertheless , E148Q helps account for recessive inheritance in an Ashkenazi family previously reported as an unusual case of dominantly inherited <span class="disease">FMF</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The presence of three frequent MEFV mutations in multiple Mediterranean populations strongly suggests a heterozygote advantage in this geographic region .
### Output Text: | The presence of three frequent MEFV mutations in multiple Mediterranean populations strongly suggests a heterozygote advantage in this geographic region . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Autoimmune lymphoproliferative syndrome with defective Fas : genotype influences penetrance .
### Output Text: | <span class="disease">Autoimmune lymphoproliferative syndrome</span> with defective Fas : genotype influences penetrance . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Autoimmune lymphoproliferative syndrome ( ALPS ) is a disorder of lymphocyte homeostasis and immunological tolerance .
### Output Text: | <span class="disease">Autoimmune lymphoproliferative syndrome</span> ( <span class="disease">ALPS</span> ) is a <span class="disease">disorder of lymphocyte homeostasis and immunological tolerance</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Most patients have a heterozygous mutation in the APT1 gene , which encodes Fas ( CD95 , APO - 1 ) , mediator of an apoptotic pathway crucial to lymphocyte homeostasis .
### Output Text: | Most patients have a heterozygous mutation in the APT1 gene , which encodes Fas ( CD95 , APO - 1 ) , mediator of an apoptotic pathway crucial to lymphocyte homeostasis . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Of 17 unique APT1 mutations in unrelated ALPS probands , 12 ( 71 % ) occurred in exons 7 - 9 , which encode the intracellular portion of Fas .
### Output Text: | Of 17 unique APT1 mutations in unrelated <span class="disease">ALPS</span> probands , 12 ( 71 % ) occurred in exons 7 - 9 , which encode the intracellular portion of Fas . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In vitro , activated lymphocytes from all 17 patients showed apoptotic defects when exposed to an anti - Fas agonist monoclonal antibody .
### Output Text: | In vitro , activated lymphocytes from all 17 patients showed apoptotic defects when exposed to an anti - Fas agonist monoclonal antibody . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Similar defects were found in a Fas - negative cell line transfected with cDNAs bearing each of the mutations .
### Output Text: | Similar defects were found in a Fas - negative cell line transfected with cDNAs bearing each of the mutations . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In cotransfection experiments , Fas constructs with either intra - or extracellular mutations caused dominant inhibition of apoptosis mediated by wild - type Fas .
### Output Text: | In cotransfection experiments , Fas constructs with either intra - or extracellular mutations caused dominant inhibition of apoptosis mediated by wild - type Fas . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Two missense Fas variants , not restricted to patients with ALPS , were identified .
### Output Text: | Two missense Fas variants , not restricted to patients with <span class="disease">ALPS</span> , were identified . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Variant A ( - 1 ) T at the Fas signal - sequence cleavage site , which mediates apoptosis less well than wild - type Fas and is partially inhibitory , was present in 13 % of African American alleles .
### Output Text: | Variant A ( - 1 ) T at the Fas signal - sequence cleavage site , which mediates apoptosis less well than wild - type Fas and is partially inhibitory , was present in 13 % of African American alleles . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Among the ALPS - associated Fas mutants , dominant inhibition of apoptosis was much more pronounced in mutants affecting the intracellular , versus extracellular , portion of the Fas receptor .
### Output Text: | Among the <span class="disease">ALPS</span> - associated Fas mutants , dominant inhibition of apoptosis was much more pronounced in mutants affecting the intracellular , versus extracellular , portion of the Fas receptor . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Mutations causing disruption of the intracellular Fas death domain also showed a higher penetrance of ALPS phenotype features in mutation - bearing relatives .
### Output Text: | Mutations causing disruption of the intracellular Fas death domain also showed a higher penetrance of <span class="disease">ALPS</span> phenotype features in mutation - bearing relatives . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Significant ALPS - related morbidity occurred in 44 % of relatives with intracellular mutations , versus 0 % of relatives with extracellular mutations .
### Output Text: | Significant <span class="disease">ALPS</span> - related morbidity occurred in 44 % of relatives with intracellular mutations , versus 0 % of relatives with extracellular mutations . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Thus , the location of mutations within APT1 strongly influences the development and the severity of ALPS .
### Output Text: | Thus , the location of mutations within APT1 strongly influences the development and the severity of <span class="disease">ALPS</span> . |