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MRC Senior Fellow . . My research focuses on understanding how molecular biology shapes brain function in healthy and diseased brains . In the healthy brain I aim at answering questions such as Which genes are responsible for variations in neural activity in the resting brain whereas in the diseased brain I want to understand which processes are causing severe malfunctions leading to neuropsychiatric and neurodegenerative disorders such as Major Depressive Disorder and Alzheimer s disease . My goal is to understand the molecular biology behind these disorders ; down the road such an understanding may result in new drug candidates . Furthermore , I am interested in developing disease biomarkers that assist in early detection of the disorder and in personalizing the treatment . Thus , my research interests are centered on topics in neuroimaging , molecular genetics , and machine learning and their combinations .. Technologies :

Assistant professor Forskarassistent . UCMR ; Bacterial Cytoskeleton Structure , Intermediate Filament Structure and Assembly Studies by Cryo Electron Microscopy . . Technologies : CryoEM

proteins;structure

Lecturer in Translational Cancer Bioinformatics . . Professional member , British Computer Society ; STEM Ambassador ; TechWomen100 Award 2018 ; Women in Tech Award Data Scientist 2018 ; BCSNI IT Professional of the Year 2019 . Background in mathematics and computing . Currently working in Bioinformatics biostatistics within stratified medicine . Interested in : data mining , unsupervised supervised learning , prognostic predictive biomarkers . Course director : MSc Bioinformatics and Computational Genomics .. Technologies :

Scientist I , Computational Biology . Run analysis pipelines on data generated from novel CRISPR Cas9 assays . Evaluate , integrate , and extend existing bioinformatics and next generation sequencing NGS tools as well as create new tools and algorithms for analyzing genomic data . Work with preclinical teams to deliver insights and recommendations to decision makers for novel CRISPR based gene editing therapies . Extend pipelines with functions that leverage novel molecular biology and troubleshoot issues , implement test cases , and fix bugs . Convert research prototype scripts into robust scientific software optimized for performance , scalability , and adherence to coding best practices . . Senior Bioinformatics Engineer with 5 years of experience working with next generation sequencing NGS data sets to perform tasks such as whole genome sequencing , gene expression analysis , targeted deep sequencing , genome annotation , and others . I build novel pipelines and codebases for processing genomic data that is used to create cell based gene therapies , including chimeric antigen receptor CAR T cell immunotherapies . Much of my current research centers on predicting , evaluating , and mitigating CRISPR Cas9 mediated off target editing events . I have a B.S. in computer science and strong interests in biology and programming , with a particular focus on genomics . I thoroughly enjoy the processing , visualization , and analysis of complex data sets , especially as they relate to human health and disease .. Technologies :

Ph.D. Candidate . . I am a First Generation College Student and Scientist in my family . My work ethic stems from watching my famoly work hard for a place in this country . Many of my science teachers and professors of the past helped shaped me and my passion to do quality research . I am looking for a position that will utilize and challenge my years of experience in protein purification , solutions biophysics , and structural biology . The nature of the projects I led can be described in one word , optimization . Optimizing expression and purification protocols for high yield and purity without sacrificing protein activity . Optimizing buffer , protein labeling , and experimental setup strategies for characterizing my proteins of interest by obtaining reproducible and clean measurments on multiple instruments such as : ITC , FP , BLI , DSF , AUC , DLS , and MP . Optimizing crystal growth conditions and cryo EM grid sample conditions for many fruitful data collections . The skills I have gained in the past 8 years was not done alone . I am a quick learner who enjoys working in highly collaborative environment . I work well underpressure in both my science and communication . Wish me luck in finding a good fit .. Technologies : CryoEM;ITC;SLS DLS;BLI;AUC;DSF;FP

proteins;characterization;expression;interaction;structure

Analytical Chemist . GMP based works Stability study Drug release . Analytical pharmaceutical research and development pharmacist with experience in drug registration and worked as a Common Technical Dossier Writer . I also served as an Influenza Vaccine Project coordinator as well as a Monoclonal Antibody Research Assistant . I did my master s at the University of Tartu , Estonia , and Uppsala University , Sweden , and completed my master s Research project which was to Validate and do targeted metabolomic profiling using a Biocrates MxP Quant 500 Kit in plasma and matching cerebrospinal fluid samples in patients with the neurological disease Myalgic Encephalomyelitis . Therefore , I have a solid experience in LC MS from this thesis . My latest strong career highlight is Analytical chemist in the stability and release testing where I keep on developing GMP work and review , deviation management . I succeeded in developing an analytical method in tablet medicine for drug registration , including developing the Assay , Identifying Impurities , Dissolution method and ensuring that the Stability indication method functioned as well as transforming all the data into the registration form . I also oversaw the Bioequivalent Study and the Biowaiver study of tablet based medicine . Therefore , I have a solid knowledge of international medicinal guidance , such as the International Conference on Harmonization ICH Q2 R1 , Q1A R2 , Pharmacopoeias including USP , BP , and Ph . Eur . During my final year internship at Pharmacy School in Thailand , I developed a serum free medium plate form for selecting high producer mammalian cells instead of a serum containing medium to decrease the time consumed in for host cell line development , which is one of the upstream process developments . During my undergraduate studies , I also maintained several part time jobs in pharmacy stores where I learned to interact with customers , handle sales as well as keep an eye on stock control . I am looking for professional work in which I could improve my talent in analytical chemistry , drug development , quality assurance , and regulations . I am the one who is willing to learn new knowledge .. Technologies :

Principal Scientist . . . Technologies :

Computational Biologist . I apply computational biology and informatics to integrate complex data types , supporting key decision making across GSK 's R D pipeline at all phases . I work closely with multi disciplinary teams of biologists , chemists , and clinical scientists to develop and implement novel computational approaches for the analysis of large , project specific genetic and genomics data relevant to multiple disease areas . The computational and transcriptomics analyses I perform directly impact target discovery and drug discovery pipeline , with the goal of ultimately helping patients with unmet medical needs . . I am a computational biologist with experience in developing and implementing novel computational approaches for the analysis of large scale genomics data . I currently enable target discovery and drug discovery pipeline decisions at GlaxoSmithKline . I also have deep experience in computational biophysics , including elucidating the dynamic effects of disease associated mutations , post translational modifications , and evolutionary changes on the function of macromolecules . . Technologies :

Doctoral Candidate . Supervised by Dr Sonja Lorenz Investigating mechanisms of HECT E3 ubiquitin ligases using cryo EM , crystallography , and biochemistry . . . Technologies : CryoEM

enzymes;molecular glues;interaction;structure

Senior Research Officer . . Specialties : Transmission Electron Microscopy , Cryo Electron Tomography , . Technologies : CryoEM

Senior Scientist . . A protein biophysicist and biochemist with over 10 years of international experience in the study of protein interactions with HDX MS . Expertise in developing MS based methodologies for the characterization of membrane protein complexes , PPIs , small molecule protein interactions and fragment screening for drug discovery . Experienced with the operation and maintenance of LC MS systems . Team work , analytical and problem solving skills cultivated across over 10 interdisciplinary projects , through close collaboration with structural and computational biologists , cell biologists and medicinal chemists . Enthusiastic and creative colleague who has a drive to seek innovative solutions to solve challenging scientific problems . . Technologies :

membrane proteins;proteins;small molecules;interaction;screening

Bioinformatics Scientist . Using statistics and computer to power biotechnology and healthcare . 1 . Developing bioinformatics pipelines to analyze omics data based on AWS and nextflow . 2 . Automating analytical report generation based on Rmarkdown . 3 . Digesting cellular heterogeneity in biological samples based on epigenetic and RNA markers . . For continuously improving human wellness , I have been devoted into the field of biotechnology for more than 15 years , aiming to develop efficient and affordable healthcare products . To this end , my research has focused on gene regulation the core process of tissue organ development and the basis of disease progression . With my expertise in bioinformatics , statistics , and evolutionary biology , I am on the way .. Technologies :

Stem cell laboratory . . I m a highly enthusiastic and ambitious biochemist , specialized in molecular immunology especially B cell T cell interaction and protein analytics PROTACS in cancer cells . I have a progressive and open mind and are willing to explore new challenges and opportunities to excel further . Currently , I m screening and characterizing blood cancer patients and stem cell donors . . Technologies :

molecular glues;developing;interaction

Bioinformatics Lead . . Data scientist deeply rooted within bioinformatics and structural biology . Thrilled by new , daring projects on the verge of impossibility . Interested in novel , multidisciplinary , challenging projects . Soft spot for translational science and intellectual property issues . Specialities : data science , machine learning , deep learning , data exploration , computational immunology , drug discovery , protein structure prediction , membrane proteins , bioinformatics , structural biology . In the past : data networks , network security , general IT infrastructure and IT management . . Technologies :

Principal Scientist , New Antibody Product Research . Working as Principal Scientist at Genmab , a biotechnology company that creates and develops differentiated human antibody therapeutics for the treatment of cancer . I have extensive experience in the discovery and characterization of therapeutic monoclonal antibodies and am also involved in antibody innovation and the development of novel antibody formats . . My main areas of interest include adaptive immunology , oncology and antibody biology and engineering . . I work as Principal Scientist in the Antibody Science Department at Genmab , a biotechnology company that creates and develops differentiated human antibody therapeutics for the treatment of cancer . I have extensive experience in the discovery and characterization of therapeutic monoclonal antibodies and am also involved in antibody innovation and the development of novel antibody formats . . My main areas of interest include adaptive immunology , oncology and antibody biology and engineering . . . Technologies :

antibodies;characterization;developing;engineering

Associate Principal Scientist . Computational analysis of fungal genomes to identify novel therapeutics . I 'm an innovative scientist with over 12 years of experience in using both experimental and computational techniques to tackle challenging biological problems of global importance . Specialties Systems biology , metabolic modeling , metabolic engineering , transcriptional regulatory network inference and analysis , computational biology , strain development , molecular biology , next generation sequencing . Current research focus Understanding how cells process the numerous signals they encounter in nature into meaningful responses requires the acquisition of in depth knowledge of their regulatory and metabolic features . One approach to facilitating this process of knowledge acquisition involves the use of predictive models that integrate data from different types of biological networks . The application of such approaches can very powerful and have broad and far reaching implications . My current research is focused on the use of computational and experimental approaches to study different algal species with the aim of improving their yields of biomass and triacylglycerols oils that could potentially be used in manufacture of renewable fuels .. Technologies :

PHD Student . Cryo EM Ubiquitin E3 ligases . . Technologies : CryoEM

molecular glues;proteins;structure

Laboratory Head . Laboratory Head Exploratory Analytical Development CMC developability assessment of novel drug substances and respective formulations oral and parenteral , across indications at the interface between research and development Physicochemical characterization of drug substances and drug products stability , solubility , dissolution Part of interdisciplinary project teams with stakeholders from research and development functions e.g. medicinal chemistry , pharmacology , toxicology , DMPK and formulation development . I am an organic chemist with 4 years of R D experience in the pharmaceutical industry , and currently part of a highly skilled and passionate team shaping the way of novel drug candidates to early stage clinical development . Pursuing my passion for life sciences , I expanded my strong background in small molecule analytics PhD at University of Cologne , Germany by computational methods Fulbright fellow at University of Notre Dame , US and techniques in synthetic and structural biology PostDoc at Imperial College London , UK .. Technologies :

small molecules;developing;formulation

Associate Principal Scientist . . Medicinal chemist working to find novel treatments for patient suffering from cardiovascular , metabolic and renal diseases . Currently working as a chemistry lead with a team of internal and CRO based chemists on the development and optimization of selective protein degraders , using the PROTAC MoA. As part of the cross disciplinary project core team , I am specifically responsible for PROTAC design , synthesis and profiling , chemistry strategy , and milestone deliveries , but also support and interact closely with adjacent disciplines . Experience from both small molecule and PROTAC projects , in early and later phase of preclinical development , and a strong believer in technology driven medicinal chemistry , including the strategic application of modern synthesis , high throughput experimentation and automation , and artificial intelligence augmented drug design .. Technologies :

molecular glues;small molecules;developing;screening

Principal Scientist . . Expertise in membrane protein X ray crystallography : screening and optimizing crystallization conditions , data collection , de novo phasing , model building , and refinement Extensive experience in biochemical and biophysical characterization of membrane proteins Interest in protein structure and function , enzymology , and drug discovery and design . Technologies : Xray

membrane proteins;characterization;structure

Senior Research Scientist . . SKILLS AT A GLANCE Assay Development and HTP screening : Using fluorescent and colorimetric assays to detect metabolites of interest in vitro with purified enzymes or cell lysates , and in vivo screening of S. cerevisiae production strains expressing enzyme variants . Protein Engineering : To increase activity , specificity and stability , and decreasing product inhibition using rational Based on Literature , MSA , Homology modelling etc . and random Homology model guided site saturation mutagenesis engineering strategies . Protein Characterization : Purification by FPLC kta , Microcalorimetry TAM , ITC and DSC , Analysis of binding affinity and physicochemical properties thermostability and reaction optimum . Laboratory Automation : Of enzymatic assays , cloning protocols , strain screening , fermentation and AC sample handling using Hamilton STAR and Zymark Rapidplate liquid handlers . Cloning and Metabolic Engineering of S. cerevisiae , B. subtilis and E. coli with a Biobrick platform USER cloning , and Crispr Cas9 technologies .. Technologies : ITC;DSC

enzymes;proteins;small molecules;characterization;engineering;screening;stability

Principal Scientist Discovery Project Team Lead . . Biochemistry and Biophysics . drug targets . membrane protein expression and purification . biochemical and biophysical characterization . FBLD . SPR Biacore . Drug discovery . Project team member . fragments . binding assays . NMR . MST . MICROSCALE THERMOPHORESIS . SAW . SURFACE ACOUSTIC WAVE . Residence time . . selected publications . . Gr dler U , Schwarz D , Dresing V , Musil D , Bomke J , Frech M , Greiner H , J kel S , Rysiok T , M ller Pompalla D , Wegener A. Structural and biophysical characterization of the Syk activation switch . J Mol Biol . 2013 . . Stefer S , Reitz S , Wang F , Wild K , Pang YY , Schwarz D , Bomke J , Hein C , L hr F , Bernhard F , Denic V , D tsch V , Sinning I. Structural Basis for Tail Anchored Membrane Protein Biogenesis by the Get3 Receptor Complex . Science . 2011 . . Schwarz D , Daley D , Beckhaus T , D tsch V , Bernhard F. Cell free expression profiling of E. coli inner membrane proteins . Proteomics . 2010 . . Schwarz D , D tsch V , Bernhard F. Production of membrane proteins using cell free expression systems . Proteomics . 2008 . . Keller T , Schwarz D , Bernhard F , D tsch V , Hunte C , Gorboulev V , Koepsell H. Cell free expression and functional reconstitution of eukaryotic drug transporters . Biochemistry . 2008 . . Schwarz D , Junge F , Durst F , Fr lich N , Schneider B , Reckel S , Sobhanifar S , D tsch V , Bernhard F. Preparative scale expression of membrane proteins in Escherichia coli based continuous exchange cell free systems . Nat Protoc . 2007 . . Schwarz D , Klammt C , Koglin A , L hr F , Schneider B , D tsch V , Bernhard F. Preparative scale cell free expression systems : new tools for the large scale preparation of integral membrane proteins for functional and structural studies . Methods . 2007 . . Klammt C , Schwarz D , Fendler K , Haase W , D tsch V , Bernhard F. Evaluation of detergents for the soluble expression of alpha helical and beta barrel type integral membrane proteins by a preparative scale individual cell free expression system . FEBS J. 2005 contributed equally . Technologies : SPR;MST;NMR

membrane proteins;proteins;characterization;expression;interaction;screening

Associate Computational Biologist . . Bioinformatics professional with a proclivity for life science and programming . I am keen to work in a fulfilling environment that constantly challenges me , helps me learn and grow both personally and professionally and , allows me to realize my full potential through my tenacity and diligence . I enjoy meeting new people and discovering different perspectives and have an unquenchable desire for frenzied knowledge .. Technologies :

Research Scientist Biopolymers . . I am a Post Doctoral Research Scientist having an experience of more than 9 years in the field performing diverse functions of Research and Development , Teaching and Lab Administration . I am currently spearheading with Zentrum f r Molekulare Biologie in der Heidelberg Universit t ZMBH as Post Doctoral Scientist , accountable for studying the functional aspects of the heat shock protein 90 Hsp90 using a variety of Biophysical techniques . I am an academically astute professional , holding Ph.D. and M.Phil . degrees in Biophysical Chemistry from Cambridge University , United Kingdom . I am proficient at interfacing with different teams and work in team spirit and integrated the twin fundamentals of research and development for translating the conceptualizations into solutions . I hold experience in handling entire spectrum of research and development activities include analyzing data , processing and publishing results , creating new research proposals , and interacting with multidisciplinary teams . Through innovative approaches , technical know how and sound exposure gained via handling research and development projects , I have gained the ability to implement research methodology to projects involving diverse experimental and analytical techniques , interpreting the research results and summarizing the research findings for presentation and or publication . During my past experience I served in the capacity of Laboratory Teacher and Research Associate . I possess keen teaching and development acumen and the ability to deliver lectures on Chemistry and Biophysical Chemistry topics . I am also skilled at handling Chemistry lab equipments . Keen to utilize my technical and analytical skills to support the research and development projects . To discuss my experiences , feel free to connect with me on LinkedIn . Technologies :

proteins;characterization

Lecturer . . I am currently a lecturer and tutor in computational mathematics at Goldsmiths University . I have had research appointments at The Alan Turing Institute , PHE , Imperial College London , University of Surrey , Max Planck Institute for Complex Systems , Institute of Theoretical Physics in Amsterdam UvA . My interdisciplinary research bridges Biology , the Physical Sciences , Social Sciences and Computer Science . I have worked and published in several fields of research , including theoretical physics , biological physics , systems biology , epidemiology and Machine Learning applied to social sciences . My work has been highlighted for relevance by the American Physical Society and has accrued more than 125 K accesses on nature.com .. Technologies :

Head of Medicinal Chemlistry . . Longstanding experience of multidisciplinary project leadership . Project Leader in the fields of Neurology CNS , Route Scouting and Process Chemistry 7 projects managed . Multiple launches of new projects 4 new projects successful launch for 10 proposed . Project leadership at various stages of Drug Discovery , from Hit ID until Early Development , including back up programs 7 projects managed so far , Phase I and Phase II compound identification . Lead of experienced Synthetic Medicinal Chemists up to 5 PhD s and graduates . Operational experience of department leadership . Head of External Chemistry , New Medicines , Medicinal Chemistry up to 74 external chemists on board . Member of Chemistry Department leadership team . Global Operation through Optimization of the UCB Compound Library , 4 year project aimed at increasing the size , quality and diversity of UCB proprietary compound library . Specific scientific areas of expertise . Hit ID and Lead Optimization . Experienced Medicinal Chemist with significant contributions as Lead Chemist into a variety of preclinical programs hit identification , hit to lead , lead optimization and candidates selection phases . Expert knowledge of GPCR s , enzymes , ion channels transporters drug discovery . Responsible for the chemical strategies and Hit ID . Strong internal and external network . Chemistry problem solver . Technologies :

small molecules;developing

Senior Researcher . Project : Combining in silico screening , structural investigation , lipid identification and assay development to unravel the specificity of Glucose Transporters . Project : Structural basis for the delivery of activated sialic acid into Golgi for sialyation . . Structural biologist combining expertise in Biochemistry cloning , expression , purification , stabilization and engineering of soluble or membrane proteins , characterization and assay development , Biophysics Protein crystallography , ITC , SPR , MST ... and Bioinformatics sequences analysis , de novo and homology modeling , molecular dynamic simulation , small molecule protein protein protein docking . I have a strong interest in linking protein dynamic with function and to apply my discoveries into drug design . With a team orientated mindset , I value collaboration , exchange and mentoring as central to catalyze creativity , motivation , and efficiency . Curiosity driven , I strongly believe that method development is essential to push the limit of discovery and therefore I always try to apply or create new approaches or technologies in order to reach my goals .. Technologies : Xray;ITC;SPR;MST

membrane proteins;characterization;engineering;interaction;stability;structure

Director , Bioinformatics . Managing a team of bioinformaticians and data scientists to develop solutions that enable in silico novel antibody and drug discovery . . Managing a team of bioinformaticians and data scientists to develop solutions that enable in silico novel antibody and drug discovery .. Technologies :

Clinical Bioinformatics Analyst I . Develop annotated genomic profiles of somatic aberrations based on massively parallel sequencing Next Generation Sequencing or NGS data in cancer patient samples study . Review genomic variant calls using propriety and publicly available tools , including but not limited to the Integrative Genomics Viewer IGV , in close collaboration with the scientific team Provide test results according to Standard Operation Procedures SOPs with the best possible quality within defined turn around times . Collaborate with technical teams in specifying requirements for tools to enhance workflow efficiency and robustness . Research Studying at Temple University has allowed me to pursue research with world reknown factuly and state of the art equipment . I am combining my knowledge of science in genetics with programming skills in Python 3 and R to assist in the advancement in knowledge . I pursued Bioinformatic research in the Institute of Genomics and Evolutionary Medicine iGEM at Temple University in Cancer Phylogenetics . Through this position , I have had the opportunity to present my research in university sponsored poster presentations and publish as a co author in several peer reviewed journals . Education I have completed my undergraduate degree with a Bachelor of Science in Biology in Spring 2021 Aspirations After finishing my studies , I will be pursuing a full time opportunity to strengthen my experience in a laboratory setting . In the future , I hope to pursue further education in Molecular Biology , Biostatistics , Computational Biology , or Bioinformatics . With my background in cancer research , I am especially interested in precision medicine and pharmacogenomics .. Technologies :

Global Study Manager . Clinical trials project management , budget monitoring , risk timeline management . I work as a Global Study Manager with a background in platform management , Structure Biology Cryo electron microscopy . Clinical trials project management Risk , timelines milestones management Budgeting monitoring Team coordination management Accountable for the implementation , monitoring and reporting of performance metrics Key contact for clients ; Liaison between Client Data management Research platform management . Technologies : CryoEM

Senior Research Associate . Senior Research Associate , Biology at Nura Bio formerly Proneurotech , Inc. https : nurabio.com Designed and executed critical experiments enabling a gene to structure workflow to support pipeline discovery programs Cloned and screened protein fusion constructs for recombinant expression of proteins prone to aggregation Purified soluble , insoluble , membrane bound bacterial and mammalian proteins to support small molecule drug discovery Optimized purification workflows using chromatography methods to improve protein yield , sample quality homogeneity Characterized protein using biophysical Octet BLI , SPR , DSF and biochemical activity assay techniques to assess quality Screened and optimized crystallization conditions to obtain well diffracting crystals to collect high quality structural data Performed crystal manipulations like crystal soak , crystal harvest , and cryoprotection to enable synchrotron data collection Processed raw datasets and solved protein structures using advanced crystallography software like HKL2000 , Phenix , Coot Managed the onboarding of Benchling , an electronic lab notebook and sample management platform , for the company . I am currently a Protein Biochemistry Research associate at Nura Bio formerly Proneurotech , Inc. specializing in Structural Biology and Molecular Biology . I recognize myself as an independent scientific researcher with over two years experience working in oncology and antibacterial drug discovery research . I have successfully demonstrated ability to work in a fast paced , collaborative work environment with attention to data reproducibility . I regard myself as an creative , flexible , adaptable , and accountable biotechnology professional with a background and experience in diverse applications of molecular biology and protein biochemistry .. Technologies : BLI;SPR;DSF

proteins;small molecules;characterization;expression;interaction;screening

Assistant Professor . Structure function studies between selected histone demethylases nucleosomes and their role in epigenetic regulation and interactions potential drug molecule . I 'm a research scientist actively involved in projects understanding epigenetics and oxidative stress from a societal point of view .. Technologies : Xray;CryoEM

proteins;interaction;structure

Senior Postdoctoral Fellow . Structural biology of virus host interactions and structure based design of improved vaccines . Experienced research scientist with expertise in structural biology and protein science . Skilled in the application Cryo EM , X ray crystallography and biophysics to determine the atomic structure of proteins and viruses and elucidate structure function relationships , with the aim of developing novel therapeutics and vaccines .. Technologies : Xray;CryoEM

proteins;characterization;interaction;structure

Scientist , Protein Science . . Integrative scientist with a focus on structural biology . Experienced with the full pipeline of mutagenesis , protein expression , purification and structural determination of multiple , large protein complexes from diverse cell types . Well versed in generating and characterizing large DNA protein complexes utilizing multiple biochemical assays , including western blotting , negative stain electron microscopy and the full pipeline of cryo EM from data collection Talos Arctica to data processing cryoSPARC , Relion etc . . Effective leader who has managed multiple students who have since moved to respectable positions . Constructive communicator , reflected by several award earning presentations , with ample experience collaborating in a team . . Technologies : CryoEM

proteins;structure

Associate Computational Scientist . . . Technologies :

Senior Scientist protein crystallography . Aim : Structural based drug design , protein production , biophysics Protein engineering , protein production , crystallization and structure determination Hit validation and characterisation , ligand binding experiments Intact MS , ITC , thermalshift assays Project management : experimental design , work schedules , resource planning , proposal writing , regular client updates . Enjoying challenges , I am an experienced biochemist with a demonstrated history of working in the biotechnology and pharmaceuticals industries . Skilled in Protein Chemistry , Biophysics , Biotechnology , Structural Biology , and Drug Discovery . Strong research professional with a PhD in biosciences from Ecole Polytechnique , France .. Technologies : ITC

molecular glues;nucleic acids;proteins;small molecules;engineering;interaction;structure

Biochemist . Biophysical analysis of proteins and peptides e.g FT IR , DLS , Fluorescence , absorbance and Thioflavin T based fibrillation analysis . ELISA analysis GMP laboratory production support and problem solving Development , robustness and validation of analysis . . Technologies : SLS DLS

peptides;proteins;characterization

Postdoctoral Scholar . . Dr. Zhang has a broad background in molecular biology , biochemistry , biophysics and pharmacology , with expertise in isolating membrane proteins , assembling lipid systems , imaging signaling pathways , processing massive data and detailing dynamic information . G protein coupled receptors GPCRs and channels play the vital role in signal transduction and comprise nearly one third of membrane proteins which targeted by approximately half of drugs marketed . He has been working on molecular understanding of their functionalities reconstituted into a lipid environment by combining method development , biochemical assay and single particle cryo EM . He devotes himself to exploring the power of cryo EM for visualizing transitional intermediates during dynamic processes in atomic detail .. Technologies : CryoEM

membrane proteins;structure

Senior Computational Biologist . Led the pipeline development and data analysis for multiplexed cell permeability assays Led customized NGS pipeline development , data analysis and biomarker discovery to support the company 's leading beta catenin program . Produced impactful results that helped the company reaching in vitro PoC and in vivo milestones , and obtain series C funding Initiated and performed machine learning studies to predict peptide properties and cell line sensitivity , and to identify biomarkers Developed visualization tools . Specialties : bioinformatics , computational biology , algorithm and software development , proteomics and genomics , cancer , immunology . Technologies :

Associate Manager . Associate Manager in DAPI Analytical Support , Biophysics Support IT Equipment . . Technologies :

Manager , Cell Informatics . . I m a result driven , self motivated and qualified computer scientist and computational biologist with 20 years of experience in high quality bioinformatics service and advanced analytics provision for genomic biomedical research and drug discovery . Specialties : Bioinformatics , Computational Biology , High throughput Sequencing Data Analysis , High throughput Phenotyping , Advanced Analytics , HPC , Distributed Systems , Cloud Computing , Database Applications , Object Oriented Software Design and Programming . Technologies :

Senior Scientist , Computational Biology . . . Technologies :

Senior Director . . . Technologies :

Associate Scientist . . Highly motivated graduate from the University of Rochester , seeking work experience in the field of biological sciences . Specifically interested in industrial laboratories working in cellular biology and genomics , but very open to opportunities related to other fields of biology .. Technologies :

Research Analyst . . International healthcare equity research . CFA charterholder . Multidisciplinary academic and industry background in computer science , bioinformatics , genetics , cellular and molecular biology . Professional Postdoctoral Master 's degree in Bioscience management . Passed Regulatory Affairs Certification exam in 2014 . . Technologies :

Advisor Biology . . I am a result oriented protein biochemist biophysicist with 14 years of experience in the field of structural biology with the aspiration to apply my knowledge of protein structure function relationship in developing products that would have a direct impact on society . In that regard , I am specifically interested in becoming a part of the pharmaceutical healthcare sector , to develop drugs and vaccines against diseases and or molecular diagnostic solutions . Highlights : An independent thinker with outstanding technical skills in the area of protein chemistry that range from expression purification of soluble and membrane proteins to their complete characterization , structure determination , and their interactions with other proteins ligands . A problem solving individual with highly analytical mind and effective time management skills , who has successfully completed several difficult research projects that have provided answers to complex biological questions , resulting in 10 publications . An excellent team player with exceptional communication skills and experience of working in multidisciplinary environments and mentoring more than 15 researchers at various career levels . Technical skills : Cloning , expression purification of soluble and membrane proteins . Biochemical characterization of proteins , enzymatic assays . Structural biology : X ray crystallography , NMR , electron microscopy negative stain , cryo , microED Assay development for protein protein and protein ligand interactions using biophysical techniques like 2D HSQC NMR , fluorescence , CD spectroscopy , MST , ITC , SEC MALS . Computational skills : Shell Scripting ; programming in R , protein DNA sequence analysis ; protein ligand docking ; protein homology modeling ; molecular visualization modeling analysis software Coot , PyMol , and Chimera . About the background photo : that 's one place and its inhabitants that I care about , above all . Not that I do n't care about the rest of the universe , but that seems to be in no avoidable danger any time soon .. Technologies : Xray;ITC;MST;NMR

membrane proteins;proteins;characterization;interaction;structure

Principal Scientist Pharmacology Team Leader . . Experienced Scientist with a demonstrated history of working in the biotechnology industry . Skilled in Biomedical Engineering Quantitative Systems Pharmacology . Strong research professional with a Doctor of Philosophy PhD focused in Bioengineering and Biomedical Engineering from The Johns Hopkins University School of Medicine . . Technologies :

Research Fellow . . Alessia Visconti 's research activity deals with the study of the genetics of human diseases . Her work focuses on the identification of genetic and epigenetics variants influencing the risk of common diseases or of related quantitative phenotypes . She has also worked on the problem of knowledge discovery in biological data , developing new approaches tailored to solve biological tasks , and on the reverse engineering of gene regulatory networks . More recently she became interested in the studying of the human gut metagenome .. Technologies :

Sr . Informatics Data Scientist . . Research data scientist working in the fields of algorithm design and data analysis with strong programming background . Experience designing custom algorithms predictive , recommendations and others , designing and training AI models , designing and querying relational databases , analyzing scientific data , rapid prototyping in scripting languages and developing production level software . . Technologies :

Director , Head of Screening . . 20 years of experience in pharmaceutical drug discovery as a team player and project leader in multidisciplinary teams . Expert in oncology research , signal transduction , cell cycle , immune oncology , DNA damage signalling . Assay development and HTS expert in biochemical and cell based screening . Management of and negotiations with external collaboration and outsourcing partners . Since January 2020 heading the high throughput screening team of 40 scientists and technicians at the Innovation Campus Berlin at Bayer AG .. Technologies :

small molecules;screening

QC Chemist . Troubleshooting of enzyme activity methods Global quality meetings Internal project management Ad hoc problem solving Evaluation of data Leadership of instrument teams Leadership of LEAN board meetings , including coordination Internal auditor ISO9001:2015 . PhD : Characterization and protein engineering of galactanase in a thesis titled understanding and predicting thermostability : galactanases as experimental model system under the main supervision of associated professor Leila Lo Leggio . M.Sc : Characterization of galactanase , Structure determination of chitosanase and crystallization of galactosidase in a thesis titled Structural and biochemical studies of enzymes hydrolysing glycosidic bonds . B.Sc : Investigation of the kinetic mechanism of sorbitol dehydrogenase .. Technologies :

enzymes;characterization

Chief Scientific Officer . . . Technologies :

Assistant Professor . . The Li Group at UCLA develops materials for energy and environmental applications . To make breakthroughs in these areas , advanced electron microscopy techniques e.g. cryo EM will be developed to establish fundamental guiding principles for the design and synthesis of next generation materials . More info : https : sites.google.com view li groupucla home https : samueli.ucla.edu people yuzhang li . Technologies : CryoEM

Professor Emeritus Director of Research . Structural Biology of Receptor Activation and DNA Repair , Structural Bioinformatics and Structure guided Fragment based Drug Discovery . Tom Blundell researches on molecular and structural biology of growth factors , receptor activation , signal transduction and DNA repair , important in cancer and other diseases . He has published 500 research papers , including 30 in Nature . He was founding CEO of BBSRC 1991 1996 Chair from 2009 , Chairman of Royal Commission on Environment 1998 2005 , Deputy Chair of Institute of Cancer Research since 2008 and President of UK Science Council since 2011 . He has written extensive software for structural bioinformatics and developed new approaches to structure guided and fragment based drug discovery . In 1999 he co founded Astex Therapeutics , an oncology company that has eight drugs in clinical trials and that was sold in 2013 as Astex Pharma to Otsuka for 886 million . In his academic lab he is focusing on the design of new antimicrobials for tuberculosis funded by FP7 MM4 TB and Gates HIT TB and targeting protein protein interactions for cancer therapeutics .. Technologies :

proteins;small molecules;screening;structure

Researcher . Project : Structural dynamics of membrane transport proteins Key techniques : Protein production and purification , Nanodisc technology , Time Resolved X ray Solution Scattering TR XSS , and Transmission Electron Microscopy TEM . I have a PhD in biochemistry and I am currently working as a postdoctoral researcher at Ume University , Sweden . My research focuses on structural and biophysical studies of membrane transport proteins . Specialties : Membrane protein production and purification , protein reconstitution in liposomes and nanodiscs , biochemical and biophysical analysis of protein complexes . I am currently doing structural biology using Time Resolved X ray Solution Scattering TR XSS and Transmission Electron Microscopy TEM .. Technologies : Xray

membrane proteins;characterization

Centre Director Systems Biology and Bioinformatics . This Centre co ordinates research , training , facilities and outreach in Bioinformatics and Systems Biology at Imperial College London . . An experience protein bioinformatician and chemoinformatician in the university sector with experience of a start up . Experience in developing world leading algorithms to model protein structure , function , interactions , networks and systems together with development of chemoinformatics software to identify novel hits and leads for drug discovery . Available for consultancy , lecturing and contract research . Scientific management Experience at co ordinating research teams Director of Centre for Integrative Systems Biology and Bioinformatics at Imperial College London see www.imperial.ac.uk cisbio Bioinformatics Head of protein bioinformatics group that developed the Phyre2 web server for protein structure prediction that has over 500,000 hits by the community . www.sbg.bio.ic.ac.uk . Developed other protein modelling tools including protein docking and protein function prediction . Systems biology Research into algorithms for the comparison of protein protein networks and into gap filling in metabolic networks . Analysis of nsSNPs from a network perspective . Medical informatics Developer of new approaches to understand the effect of nsSNPS on proteins and their likelihood to cause disease . Spin out Founder and Director of Equinox Pharma Ltd www.equinoxpharma.com which exploits chemoinformatics for drug discovery . Computer aided drug discovery Co developer of Equinox s INDDEx approach for logic based drug discovery which finds comprehensible rules for structure activity relationships and performs exceptionally well at scaffold hopping in computational screening to find novel hits . Scientific journals Experience at scientific publishing via journal boards including Associate Editor of Journal of Molecular Biology . Teaching Extensive experience of postgraduate and undergraduate teaching in bioinformatics and theoretical systems biology Deputy Director of MSc in Bioinformatics and Theoretical Systems Biology at Imperial College .. Technologies :

Scientific Advisor . Incubating transformative solutions to central challenges to biotechnology . . Systems biologist focused on developing comprehensive computational models to enable personalized and predictive medicine and rational bioengineering . Focused on innovative research and engineering . Experienced in molecular cell biology , computational modeling , software engineering , and scientific visualization . Committed to teaching and mentorship .. Technologies :

Principal Scientist . . Specialties : Machine Learning , Optimization , Data Mining , Operations Research , Artificial Intelligence , Game Theory , Multi Agent Systems , Robotics , Algorithms , Computational Complexity , Bioinformatics , Digital Marketing .. Technologies :

Research Associate IV . . Experienced Protein Scientist with a demonstrated history of working in the biochemistry biophysics research . Skilled in Protein biochemistry , Fluorescence spectrometry , High throughput assay development , Biotechnology , Nuclear Magnetic Resonance NMR , CD spectroscopy . Strong research professional with a Doctor of Philosophy focused in Pharmaceutical and Bioanalytical Chemistry , and Master 's in Computer Aided Drug Design . . Technologies : NMR

proteins;characterization;screening

Akademischer Mitarbeiter . . I am a Doctoral Student at the Institue for protein Biochemistry , University of Ulm . I work in the field of Structure Biology in the Cryo Electron Microscopy section .. Technologies : CryoEM

proteins;structure

Computational Research Scientist . . Experienced Computational Biologist with a demonstrated history of working in the research industry . Skilled in Research in structural biology , Data Analysis , Programming and Methods development . Strong research professional with a Doctor of Philosophy Ph.D. in Biophysics from Institute of Mathematical Problems of Biology of Russian Academy of Sciences . Experience in Computational biology at Lawrence Berkeley National Laboratory USA . . Technologies :

Scientist II . . Chemical engineering Ph . D with a diverse background in bioprocessing , biochemical engineering , and cell and gene therapy . Skilled in molecular biology techniques , bioprocess development , and computational methods . Demonstrated leader and mentor .. Technologies :

Principal Scientist . . Current Industry Expertise : ADME Sciences , PBPK modeling , PK PD Efficacy , NONMEM and QSP modeling and simulation M S in Inflammation and Immunology Portfolio projects in Rheumatoid Arthritis , Inflammatory Bowel Disease , Topical Applications and Internal Medicine Obesity Academic Expertise : Systems Biology , Signal Transduction , Arts of Modeling , Simulation and Optimization Professional Service : Science camps for high school students , Editorial and reviewer duties , Mentoring students belonging to the LGBTQ spectrum in STEM fields I prefer working with people with joy in their hearts , courage in their actions , excellence in their pursuits , equity in their relationships . Technologies :

Nanofabrication Research Service Center NRSC Equipment Trainer and Maintenance . At Texas State University , Nanofabrication Research Service Center NRSC facilitates a large clean room area occupied by different deposition , etching and device manufacturing equipment . Besides working as equipment trainer , I also participate in HV UHV equipment maintenance e.g. , sputter target replacement , cryo pump regeneration , deposition chamber cleaning etc . . Nanofabrication Research Service Center NRSC equipment trainer and maintenance . Participated in project based teamwork graduate level experimental course works on thin films deposition characterization techniques and have a strong hands on research experience in cleanroom area with the expertise on semiconductor fab processing e.g. thin films deposition , device fabrication and their characterizations . Specialties : Growth : PVD : DC RF Sputtering , Electron Beam Evaporation , Pulsed Laser Deposition PLD , Atomic Layer Deposition ALD Metrology Characterizations : Ellipsometry , XRD , XRR , AFM , SEM , FIB , XPS , Electrical Characterizations I V , C V , Hall Measurements . Fab processing : Design of Experiment , Wet Etch , Thin Film Deposition , Photolithography , Lift off . Devices : Schottky Diodes , RRAM , MOSCAP . Maintenance : Nanofabrication Research Service Center NRSC equipment trainer , HV UHV equipment maintenance e.g. , sputter target replacement , cryo pump regeneration , deposition chamber cleaning etc . Programming Language : Python , MATLAB , Predictive Data Science Machine Learning Statistical Process Control SPC . Technologies :

Postdoctoral Researcher . Using cutting edge methods to directly visualize gene products in cells in their living state with special emphasis on cytoskeletal assemblies and molecular motors Experience in the gene to structure pipeline , including construct design , standard molecular biology techniques , recombinant protein expression , followed by in situ molecular imaging using cryo electron tomography cryo ET Method development for cryo electron microscopy cryo EM Utilization of cryo FIB milling of frozen hydrated biological samples Experience using software for 3D reconstructions of cryo tomography samples Experience characterizing the performance of an imaging system such as a direct detection camera or energy filtered detector . Dedicated and persistent researcher with a solid background in biochemistry , biophysics , molecular and structural biology . Extensive experience in biochemical and biophysical characterization of nucleic acid and protein , recombinant protein expression and purification , X ray protein crystallography , and CryoEM ET .. Technologies : Xray;CryoEM

nucleic acids;proteins;expression;structure

. . A young professional with clinical pharmacy working experience in Estonia , Spain and Portugal . Eagerness to venture into the scientific world led me to pursue a master 's degree in Pharmaceutical Sciences at KU . The culmination of my time at KU is a 60 ECTS project on the functional studies of GPCR G protein interface determining selectivity with Rasmussen lab .. Technologies :

Turing Research Fellow . Building a research team in computational biology , particularly developing new statistical and computational methods for designing genetic experiments . see https : daphneezer.wordpress.com and https : scholar.google.co.uk citations user kY0ZQoIAAAAJ hl en An EPSRC funded research associate position is available in my group . PhD students are encouraged to apply through the Alan Turing Institute . How can we utilise crowdsourced science to its full potential How can we optimise the design of experiments to save time and effort while maximising biological insights How can we develop new statistical tools to extract more meaning from existing datasets such as normalising them to be able to do meta analysis or utilising the functional structure of the data to have a more detailed analysis . . Technologies :

Senior Application Scientist . . I am a life scientist with a background in developmental biology . My research has focussed on questions of nano biosafety , regulation of stem cells , maintenance of cell polarity , and neuropeptide GPCR signalling systems . I approached these problems with methods that range from in silico to in vitro and in vivo . I have successfully driven research projects in international and interdisciplinary collaborations and I thrive on the synergy created by professionals that share a vision and strive after the same goal . For many years I have been teaching students in cell biology , developmental biology and human physiology . My colleagues appreciate my analytical and creative approach to problem solving and that I am always willing to share my knowledge and ideas or lend a helping hand . Students and friends value my ability to explain complex subjects with passion and patience . In my working environment I value structure , transparency , direct communication , and a positive , open atmosphere .. Technologies :

. . J'ai obtenu mon doctorat en biologie structurale en 2020 durant lequel j'ai pratiqu et g rer divers projets de mod lisation mol culaire , traitements et interpr tation de donn es de microscopie lectronique . J'ai effectu une ann e de postdoctorat dans laquelle j'ai acquis de nouvelles exp riences en microscopie lectronique et plus pr cis ment en sonde ionique focalis e FIB . Mes domaines de pr dilection sont la microscopie lectronique et la mod lisation mol culaire . J'ai pu explorer et pratiquer diverses m thodes do nt la cryo EM en particules simples , cryo tomographie et FIB . J'ai travaill sous environnement Linux et Windows , je maitrise les outils du package Microsoft Powerpoint , Word , etc ainsi qu'une panoplie de logiciels sp cialis s dans les domaines de la microscopie lectronique et mod lisation mol culaire . Je suis d sormais la recherche d'une nouvelle opportunit dans une entreprise dynamique dans laquelle me projeter pour m ' panouir professionnellement et long terme . Je suis galement ouvert des propositions en dehors de mon champ d'expertise puisque j'aime apprendre , et d velopper de nouvelles comp tences . N'h sitez pas me contacter mes coordonn es de mon profil LinkedIn pour en discuter .. Technologies : CryoEM

structure

Postdoctoral Scholar . Recombinant Natural sourced membrane ion channel reconstitution in lipid nanodisc Sample preparation for negative stain imaging , cryoEM grids frizzing , screening Data acquisition using SerialEM in Titan Krios , image processing in relion , cryoSPARC . A benchmark structural biologist and protein biochemist with 7 years experience gleaned a handsome amount of ideas , methods , techniques now time for transferring those scientific findings to the community . Sharpened the knot solving aptitude in research from stubborn protein expression , purification , enzyme catalysis , product formation to product separation , sketching the project plan and bring it to the benchmark . Conducted research in different platform including Protein Biochemistry Structural Biology CryoEM and X ray crystallography Bioanalytical Chemistry converging those application in one point making and characterizing multi variant scaffold of therapeutic agent in drug discovery . Research Skills : Molecular Cell Biology : Construct design dibac , multibac , PCR , Agarose gel electrophoresis , DNA gel purification , DNA pieces assembly , Plasmid preparation , Transformation DH5 alpha transposition DH10BAC , Bacmid isolation . Protein Expression : Mammalian cell culture Integral Membrane Protein expression in HEK293 cell lines . Insect cell culture Preparation of recombinant baculoviruses and gene expression with Bac to Bac expression system , membrane protein expression in sf9 cells , High five cells . Bacterial cell culture Protein expression in E. coli strain including BL21 DE3 , SoluBL21 , T7 Express lysY Iq . Protein Purification : Recombinant and native sourced protein purification by Affinity SEC Ion Exchange Chromatography AKTA FPLC Unicorn , BioRad ChromLab Protein Complex Assembly : Multiprotein complex association of megadalton size analyzed by SEC MALS , Size exclusion chromatography and immobilized by crosslinking for cryoEM structure determination . Structural Biology : Negative stain imaging using Tecnai T12 transmission elelctron microscopy CryoEM sample preparation , grids freezing , grids screening using Glacios Cryo TEM TEM single particle data processing in Relion , cryoSPARC . Separation Detection : High Performance Liquid Chromatography HPLC , MALDI TOF , NMR Spectroscopy others : Western Blot , UV vis , Fluorescence spectroscopy , Dynamic Light Scattering DLS , Differential Scanning Fluorimetry DSF , Isothermal Titration Calorimetry ITC SKETCH THE INNOVATION IN THE SKYBOARD , MAKE IT HAPPEN , HAND IT IN TO THE COMMUNITY Email : Kazi.lingkon outlook.com Phone : 419 973 6660 . Technologies : Xray;ITC;SLS DLS;DSF;NMR

membrane proteins;proteins;characterization;structure

Graduate Student . . Interested in cryo EM and cryo ET methodologies and its applications to neurobiology and cell biology . Currently a PhD student in Elizabeth Wright 's lab in the Department of Biochemistry .. Technologies : CryoEM

proteins;structure

Lead Biology Project Manager . . I am passionate about science and drug discovery enabling to dissolve diseases and bring benefit to the patients . Currently I am working in an interdisciplinary team as project lead and scientist . During my PhD I worked on an interuniversity target discovery project . In my future career I would love to proceed in target discovery and project management in a biotech pharma environment . . Technologies :

small molecules

Senior Expert Science Technology . . I am currently a formulation project leader at Novartis technical research and development . . As formulation project leader I executed a number of early phase projects including complex parenteral dosage form from preclinical to clinical stage . I possess a strong understanding of formulation and process development , quality improvement techniques , root cause investigation , risk assessment etc . I have gained good knowledge of scale up GMP manufacturing from lab to pilot plant for complex parenteral formulations e. g. , PLGA microparticles , oparticle , liposomes , sgRNA , etc . . I supervised several postdocs and trainees . I am actively collaborating with universities around the globe and I believe collaboration is the key to great innovations . . for info about my publications see below : . https : scholar . google . com citations user 3Gf6Z4kAAAAJ hl en . Technologies :

Head of Research Software Engineering . . . Technologies :

Project Director , Research Services Division . . Medicinal chemist and project leader with over ten year experience in drug discovery development . Strong cutting edge knowledge and working experience on modern medicinal chemistry , drug design , screening tools for drug discovery , and lead optimization . Demonstrate leadership , establish and manage collaborations with internal external collaborators , scientific advisors and consultants . Track record on scientific publications and recognized review experience for top ranked peer reviewed journals in medicinal chemistry . Multi lingual speaker and excellent communicator deliver comprehensive scientific presentations to internal and external collaborators and stakeholders . . Key Skills : organic synthesis , chemo enzymatic synthesis , carbohydrate chemistry , analytical chemistry , organic process R D , computer aided drug design , lead optimization , structure activity relationship SAR , pharmacodynamic pharmacokinetic ADME studies , combinatorial library screening , high throughput screening , liposome oparticle formulations , glycan polymer glycan protein conjugation , in vitro protein ligand binding assays , hands on animal models in immunology , scientific writing reviewing . Technologies : ITC;SPR;FP

proteins;small molecules;interaction;screening

Research Specialist in biomolecular NMR and scientific computing . Major expertise in structural molecular biology , data processing , data analytics , biomolecular NMR , biomedical project management and scientific computing . . The Biomolecular NMR Spectroscopy Platform BNSP at the ETH in Z rich serves the advancement of research in the area of nuclear magnetic resonance NMR within the Department of Biology . . . I have a profound interest in bio medical research , especially biomolecular NMR , and cutting edge information technology . 16 years of experience as a scientist in the pharmaceutical industry and academia . Record of achievements in scientific computing data science machine learning and statistical modeling : delivered data mining solutions for pharmaceutical research . . Strong track record of scientific achievements in biomedical research , especially biomolecular nuclear magnetic resonance NMR . Successfully contributed to drug discovery project in major pharmaceutical company . Expert for lead discovery , fragment based drug discovery and structure based drug design . Therapeutic areas : Oncology , Infectious disease , Inflammation , Neuroscience . I have more than ten years of experience as a project manager in biomedical research and contributed to various successful drug discovery projects in oncology , inflammation and cardiovascular diseases as an expert for lead finding and early stage pharmaceutical research . My skills cover structure determination of proteins and RNA using NMR , computational biology , molecular modeling , structure based drug design , cheminformatics , protein ligand docking , MD , homology modeling , chemical library design , biophysical studies for proteins and RNA NMR , DSF , SPR , ITC , DSC . Assay technologies TR FRET , FP , FLT . Specific computational skills : . Data science , big data , data mining , KNIME , machine learning , deep learning , Python : pandas and scikit learn , R , Linux , UNIX , MS Windows , Mac OS , AWS , Scripting , bash , tcsh , awk , sed , Java SE8 , C , Web development , HTML , CSS , JavaScript , Database , SQL and noSQL , Molecular modeling , computational biology , cheminformatics , NMR , MOE , Pymol , RDKit , CHARMM , Matlab , Mathematica . Technologies : ITC;DSC;SPR;DSF;NMR;FP;FRET

proteins;small molecules;interaction;screening;structure

PHD Student . . I 'm a person with a drive for immunology and the molecular science behind possible treatment approaches against cancer , viral infections , or immunodeficiencies . The study projects I 've done have been focusing on targeted therapy and personalized medicine , fx . antibody delivery across the blood brain barrier , detection of tumor antigens , targeted therapy via utilization of dendritic cells and monocytes including adoptive cells therapy as another immuno therapeutical option . Additionally , projects about the positive effect of laughter on acute pain and surgical treatment options against obesity in relation to public health have been my projects during the first years as medicine with industrial specialization student at Aalborg University . My latest project at the Department of Clinical Immunology , at AAUH , was about developing a biological scientific screening tool in order to diagnose autoimmune illnesses . The screening tool can detect autoantibodies reactive towards essential signaling protein receptors as the G protein coupled receptors GPCR such as the beta 2 adrenergic receptor or the muscarinic receptor 3 or 4 . The project has also implemented a functional assay to detect the cellular activation to these receptors in the milieu of autoantibodies from plasma samples achieved from autoimmune ill patients . As a person , I 'm ambitious and committed to my work , especially if the work is immuno physiology and the work leads to new knowledge . Also , I acknowledge my team members , fx . what role they want to play in a group . I myself , am an initiator and can very well function as a leader of a group . As an example , I 'm a board member of the Dansk Retriever Klub Region Nordjylland , where I organize gun dog training , working tests , and hunting related events . I sometimes participate with my own working dog , a dark colored golden retriever . If I may say so , I do have skills with throwing pigeons for the hunting dogs . Feel free to ask me anything about this area , and I will elaborate . During my time at Aalborg University , I volunteered as the chairman for a university run called UniRun from 2013 2016 . When I 'm not working I love a fresh run , nice food , and good company from friends , colleagues , or my partner . So if you want to experience me fully enjoyed , you can take me out running , followed by a light lunch or delightful dinner and talk about dog training or immunology . Cover image borrowed from Cambridge Bioscience https : www.bioscience.co.uk cpl robust neutrophil extracellular trap assay kit . Technologies :

antibodies;membrane proteins;interaction

Statistical Genetics Researcher . PIs : Alexander Gusev and Alkes Price Developed statistical methods to characterize the genetic basis of complex diseases including diabetes , schizophrenia , and cancer in human populations Derived a novel method of moments estimator of a quantity known as heritability mediated by gene expression levels . Established unbiasedness of estimator via derivations and simulations . Applied method to real human disease genetics data from UK Biobank and RNA seq data from the Genotype Tissue Expression Consortium . Wrote first author publication in Nature Genetics cited 100 times since publication in 2020 . Check out my personal website here : https : douglasyao.github.io I 'm a PhD student in the Bioinformatics and Integrative Genomics program at Harvard Medical School . My interests are in developing statistical methods to understand the genetic mechanisms of complex disorders such as diabetes , schizophrenia , and cancer from genome wide association studies . I 'm also developing multiplexing strategies for high throughput cell based assays that read out the full transcriptome across 1000s of treatment conditions such as CRISPR perturbations and drug treatments , with the goal of increasing the throughput of such assays by 1 to several orders of magnitude over existing approaches . . Technologies :

Manager of Assay Research and Development . . I am a collaborative and results driven Biochemist . I enjoying mentoring other scientists , and especially enjoy taking a deep dive into seemingly intractable technical problems . Some of my specific skills include : Assay development Training of other scientists Conformance to current Good Manufacturing Practices cGMP Structural biology X ray crystallography and cryo EM Recombinant protein expression and purification Synthesis and purification of nucleic acids High throughput robotics Molecular Biology . Technologies : Xray;CryoEM

nucleic acids;proteins;structure

Research Engineer CDI . Member of the molecular biophysics core facility in Institut Pasteur . Characterization of secondary and tertiary structure of biomolecules in solution . Characterization of hydrodynamic properties of biomolecules in solution such as intrinsic viscosity , molecular mass , oligomerization state , stochiometry and interactions . Official implementation in 2017 of the service of Quality control of purified proteins mostly dedicated to Institut Pasteur teams . More than 500 protein samples have been tested since the service creation . Spread knowledge with the cours de Biochimie des prot ines and the Integrative and cellular structural biology EMBO course . Advice users and research teams . Practical skills : Analytical ultracentrifugation XL I and Optima Static light scattering Omnisec Dynamic light scattering DynamoPlatereader III MALDI TOF UltrafleXtreme NanoDSF Prometheus Viscosizer TD Circular dichroism J1500 UV and fluorescence spectroscopy I train people on these instruments . . Research Engineer at the molecular biophysics facility , Institut Pasteur . Since 2022 : In charge of the spectroscopic line with circular dichroism device , stationary phase fluorimetry , differential scanning fluorimetry and UV spectroscopy . The responsibility includes the training of new users , the maintenance and know how of instruments , the understanding of the technology allowing the monitoring of short , medium and long term interaction with researchers , beginners or experts who need to complete their studies by biophysical measurements . Since 2017 : I run the quality control of purified proteins service . This service was officially launched in 2017 to help the research teams of Institut Pasteur and outside that had troubles in purifying their protein of interest and especially had difficulty to complete their downstream applications Cryo EM , X Ray crystallography , activity tests , binding tests , etc . I have set up an experimental workflow that allows research teams to obtain a full qualitative control QC of their purified proteins using DLS , MALDI TOF , UV spectroscopy , nanoDSF and to help them to identify conditions in which their proteins is best behaved . Currently , around 350 proteins year are analyzed . Since 2015 : I collaborate with research teams of Institut Pasteur and other research centers on the characterization of the mass , size , shape , and stoichiometry of their biomolecules . To solve these questions , I use several and complementary approaches such as analytical ultracentrifugation Optima AUC and Proteome Lab XLI , dynamic light scattering DynaPro PlateReader 3 , SEC MALS Omnisec and Taylor Dispersion Viscosizer TD . As some questions are more challenging than others , I implement new experimental strategy using my expertise . This added value is recognized in scientific papers that I have co authored https : scholar.google.com citations user g8y3NR8AAAAJ hl fr oi ao . Development part : I have published work on the determination of intrinsic viscosities of biomolecules using the Viscosizer TD . https : doi.org 10.1007 s00249 020 01492 3 . Technologies : Xray;CryoEM;SLS DLS;AUC;DSF;CD

proteins;characterization;structure

Postdoctoral Fellow . . AHA Postdoctoral Fellow interested in proteins that help shape and organize cellular organelles and their involvement in human diseases . I use biochemistry and structural studies , like cryo ET , cryo EM and X ray Crystallography to understand how protein complexes function at membranes .. Technologies : Xray;CryoEM

membrane proteins;structure

Bioanalytical Scientific Monitor . Bionalytical Monitor for Clinical studies and outsourcing . Highly motivated and pro active scientist with almost fifth teen years experience in drug discovery and more than five years in drug development in regulated environment . Area of expertise : . Hybridoma and B Cell managing for Antibody discovery campaign . managing and programming semi and full automated platforms Tecan , Hamilton , Beckman Coulter , Gyros . cell biology , biochemistry , cell imaging . assay development and validation for PK PD IG and study samples analysisin GxP regulated environment . data managing with good hand on of statistical software . implementation of secured and data with electronic notebook eLN in regulated environment . training to end user for software and new technologies . Technologies :

antibodies;developing

Scientist Lab Manager . . Specialties : I have 10 years of experience with animal cell cultivation in suspension and adherence ; expertise in cultivation process development , small and pilot scale . During this time , I have taken part in different projects for process development for CHO HEK cells , proliferation of human cells for biopharmaceutical process optimisation , including production of biopharmaceutical protein antibody , glycoprotein in view of clinical Phase1 for toxicological tests or as tool for research . I am working as a lab manager and researcher in Dr. Veronique Chotteau group , CETEG , Dept . Industrial Biotechnology , Engineering Sciences in Chemistry , Biotechnology , and Health , CBH , KTH . I find it stimulating to work in a target oriented environment where I can use my analytical and professional skills . My responsibilities have been coordinating , planning and leading many biopharmaceutical projects with process development optimisation and protein production . I am involved in the execution , data analysis , and documentation . I am also responsible for CETEG day to day activity planning , educational and training of the students and staff . In general , my qualifications and skills have been gained from several years of experiences as a researcher , senior process scientist , project coordinator , project leader , teacher and validating . Moreover , I have also experience with E.coli cultivation process development , Recombinant protein production , process development , fed batch bioreactor cultivations , membrane proteins and surface display molecular biology cell physiology Protein purification Plasmid DNA purification GMP production . Technologies :

antibodies;expression

Senior Scientist , Microbial Physiology . Participate in initial strain characterization , production , testing and release of cell banks for GMP as well as development of DS production of Live Biotherapeutical products LBP with focus on process development by small scale fermentation platform . Dedicated and experienced scientist with a broad expertise obtained through many years in industrial biotech R D. Motivated by obtaining results in a challenging , honest and good collaboration . Proven results based on in depth knowledge , analytical capabilities and thoroughness . Expertise within microbiology , small scale fermentation , microbial physiology , cell banking , automated assays and data management . Hands on experience in the laboratory . Major achievements include optimization of microbial systems for production of enzymes and biological compounds by development of small scale fermentation methods and assays combined with mutagenesis , automation , high throughput screening and data management . Many improved production strains Aspergillus and Bacillus have been delivered . Recent experiences within strict anaerobic bacteria for live biotherapeutic products . This includes cell banking , strain risk assessments and cell bank characterization phenotypic and genotypic incl . antimicrobial susceptibility testing relevant to potency , safety and GMP production . Also media and process development based on small scale screening platform . COMPETENCES : GENERAL ISO certified work GMP Knowledge of LEAN Electronic documentation Review , reporting Data management Statistical analysis , basic level Reporting , presentations Project management International collaboration Patenting Supervision of technicians Hands on in laboratory TECHNOLOGIES Microbiology Bacteriology Fermentation in MTP , 10 1000 l Fermentation in flask 10 200ml Bioreactor fermentation , 1 L , basic level Microbial physiology Cell banking Assay development Enzymes Lab automation , basic level High throughput screening Strain improvement Classical mutagenesis Molecular biology Bioinformatics , basic level Electrophoresis Immunological methods . Technologies :

Research Engineer in biochemistry wetlab of Bioinformatics Unit at Institut Pasteur . Project : Cryo electrotomography study of the Heme Acquisition System produced in bacteria minicells Missions : Optimization of expression in E. coli and purification conditions of membrane and soluble proteins . Optimization of cryo EM conditions for structural analysis of several membrane complexes . Lab Manager of wetlab of the Unit . Skills : Cryo EM : Able to run a complete workflow on a Glacios microscope . Lacey and carbon grid preparation freezing , clipping , loading . Data acquisition for 2d pictures . Tomography should be learned next year with the cryoEM platform of Institut Pasteur of Paris . Biochemostry : autonomous protein purification on AKTA systems affinity chromatography , gel filtration . Lab Manager : PhD students formation , orders , stocks . English : profesionnal use . Langage I mostly use to teach PhD students to our lab techniques . . . Technologies : CryoEM

membrane proteins;proteins;expression;structure

Senior Scientist , Bioinformatics . . I am a computer scientist working on computational tools that enable new biological insights . My Ph.D. and initial post graduate work were in formal system verification . I then retrained into bioinformatics , seeking to contribute to biomedical applications , and joined the Broad Institute . Topics of my work include assembling of human and pathogen genomes from high throughput sequencing data , finding genetic variants subject to positive selection pressure , and simulating the spread of mutations through populations .. Technologies :

Scientist R D Genetics . Primary responsibilities are tending to the data science needs of the long read sequencing team . Developing deep knowledge of core principles of long read sequencing platforms . PacBio , ONT , Bionano Offering computational support to amplification free targeted sequencing experiments on a PacBio Sequel IIe instrument . Assessing off target effects in sequencing data and identifying root causes upstream . Building pipelines and automated workflows for any required data science applications . e.g. primer design Generating clear , comprehensive tables and visualizations for presentations and reports . Attending virtual events and reviewing literature to keep up to date on recent developments in long read sequencing . Further tasks include : Offering insight to optimization of cloud based bioinformatic pipelines . Aiding in instrument installation and networking . Attending meetings with collaborators and taking detailed minutes . . Genomics Scientist at Quest Diagnostics . Master of Science in Biomedical Engineering . Primarily proficient in computational genomics and untargeted metabolomics analysis .. Technologies :

Associate Scientific Director . Team lead protein crystallography 5 scientists Structural research and crystallography support for cancer research and cancer immunology projects . Pillar co lead for WP4 protein production in the IMI2 funded EUbOPEN Consortium . BI representative in the SGC and EUbOPEN chemical probe Joint Management Committees . . I am a trained protein crystallographer with ten years of industrial experience . Combining my CRO and drug discovery experience I developed a strong passion for fragment based drug discovery approaches and supporting or leading teams on the difficult track from NTC proposal to H2L chemistry . Currently , I am leading the protein crystallography team at the Boehringer Ingelheim site in Vienna . In my role as BI representative on the SGC Joint Meeting Committee and WP4 Protein production co lead in the IMI funded EUbOpen consortium I support open science initiatives .. Technologies : Xray

proteins;small molecules;engineering;structure

Senior Bioinformatician for the Department of Immunology . Working with department faculty , staff , and students on analysis of their data using various machine learning and statistical techniques . I also work as a liaison for department personnel with members of IS , Bioinformatics , and the Broad , as well as teaching students and post doc 's . In addition I created and run the departments bioinformatics seminar series , and manage the departments bioinformatics budget . Software development in Perl , MATLAB , R , PHP , Javascript Provide statistics support Use machine learning in the analysis of experimental results Developing software pipelines for image analysis and the the analysis of NGS data Management of multi lab projects leading to publication Developing Division strategy regarding resources for data analysis Responsible for teaching courses on software engineering and data analysis Teach Software development in R Fall Teach RNA seq analysis Spring Teach Applied Statistics Fall Experimental Design Clinical Trial Design Statistics and Sample size Management of Students and research scientists Full stack developer Manage the departments Bioinformatics Seminar Series . Bioinformatician with over 10 years of experience in software engineering , statistics , machine learning , and systems administration . In terms of software development I am a full stack developer , and a system administrator with experience on Windows Server in production environments . I also have over 10 years of experience in software engineering for machine learning and scientific computing applications in biotech . I am currently interested in using machine learning and data science techniques to solve issues with heart failure , and immunology cancer . I now spend most of my time looking for ways to apply statistical models to problems in cancer immunology , usually written in R and python on a SLURM HPC cluster . In addition to my research I teach applied statistics at HMS and am the head teaching fellow for several machine learning courses at Harvard .. Technologies :

Senior Research Project Leader . Biotherapeutics Discovery , CRO Manager , Mentor . . Senior Research Project Leader with long term experience in Drug Discovery . Delivered clinical candidates currently in Phase I and II . Project leader in Biotherapeutics Biologics pre clinical research . Experience in antibody discovery , profiling and optimization . Leadership in multidisciplinary and transatlantic teams through internal and external collaborations . Team oriented work style , organized and process driven . Likes to teach and mentor . . Technologies :

antibodies;biologics;engineering;screening

Senior Scientist . Senior Formulation Scientist at Oral Formulation Research department Solid dosage forms for the oral delivery of peptide and protein therapeutics Enhancing oral bioavailability of biomacromolecules through technological innovation . Background PhD in Pharmaceutical Sciences cum laude , 2016 10 years hands on experience in oral drug delivery , particularly therapeutic peptides and proteins 10 years hands on experience in lipid and or biopolymer based nanoparticles and other advanced drug delivery systems Specialised in permeability solubility stability enhancement , targeted delivery controlled release Gastrointestinal physiology ; digestion and absorption dynamics , including in vitro modeling Solid dosage forms for oral delivery of biologics PK PD analysis Food hydrocolloids and influence of food digestion on oral drug bioavailability Achievements : PhD 2012 2016 : Key contribution to a large scale European project with multiple collaborators and a global leading pharmaceutical company . 2 patents and 4 high impact papers JCR x 2 , ADDR , AM . Outstanding PhD Thesis Award of 2016 . Postdoc 2017 2020 : Successful delivery of government and industry funded research projects . Co supervision of 5 PhD and MSc students . 1 patent and 5 high quality papers JCR , JCIS , etc . . Catalyst Leader Grant from the Royal Society of New Zealand 2019 . Research Officer at Massey University 2020 2021 : Successful management of relationships with multidisciplinary specialists , including partners from academia and from industry . Leading an industry academia cofounded research centre for new product development . Accredited as PhD supervisor . Senior Scientist at Novo Nordisk 2021 Present : Research early development of solid dosage forms for oral peptide delivery Other relevant : Review Editor of 1 international journal Frontiers in Drug Delivery . Reviewer for 20 international journals such as Journal of Controlled Release , Drug Delivery and Translational Research , ACS Biomaterials Science Engineering , Food Hydrocolloids , etc . A few invited talks in universities and conferences .. Technologies :

peptides;developing;formulation

PostDoc Scientist in Antibody Development . . Recent publications : Megabodies expand the nanobody toolkit for protein structure determination by single particle cryo EM . Nature Methods 2021 DOI : https : doi.org 10.1038 s41592 020 01001 6 Single particle cryo EM at atomic resolution . Nature 2020 DOI : ttps : doi.org 10.1038 s41586 020 2829 0 Nanobodies to study protein conformational states . Current Opinion in Structural Biology 2020 DOI : https : doi.org 10.1016 j.sbi.2020.01.003 An improved yeast surface display platform for the screening of nanobody immune libraries . Scientific Reports 2019 DOI : https : doi.org 10.1038 s41598 018 37212 3 Cryo EM structure of the human 1 3 2 GABAA receptor in a lipid bilayer . Nature 2019 DOI : https : doi.org 10.1038 s41586 018 0833 4 GABAA receptor signalling mechanisms revealed by structural pharmacology . Nature 2019 DOI : https : doi.org 10.1038 s41586 018 0832 5 . Technologies : CryoEM

antibodies;structure

Principal Computational Scientist . . First and foremost , I consider myself to be a lifelong learner . This is the main reason why I decided to pursue a career in multidisciplinary science . Here , I have had the opportunity to develop skills and competencies in a wide range of bleeding edge research techniques in the fields of Bioinformatics , Structural Biology , Molecular Simulation , and Machine Learning . With this diverse , multidisciplinary toolkit of skills , I feel that I am able to provide answers to challenging questions using unique strategies . My many years of performing scientific research have helped me to become comfortable in the analysis of large , complex data sets . Indeed , as a matter of routine , I use statistical packages R Statistics and scripting languages Python , Perl , C shell to analyse and process image and simulation data . While I can work independently or as part of a team , my best achievements have resulted from taking a leading role within the multidisciplinary team of researchers . As the project lead , I like to identify and use the key competencies of the individual team members . This strategy has led to a number of successful publications . . Technologies :

Scientist I . . I 'm a biochemist with experience in developing native mass spectrometry , cryo electron microscopy , and cryo electron tomography techniques to study dynamic protein and protein : nucleic acid complexes . My graduate studies focused on building collision induced dissociation assays for probing conformational changes in kinase : inhibitor interactions and protein : peptide interactions . Currently , I 'm working on a cryo electron microscopy cryo electron tomography pipeline to assess heterogenous ribosome assembly intermediates . I enjoy pushing the envelope in new technologies to study systems that frustrate traditional biophysical technologies . Outside of benchwork , I am passionate about science communication and outreach .. Technologies : CryoEM

nucleic acids;peptides;proteins;interaction;structure

Vice President . Vice President of Partnerships and Portfolio within RNA and Gene Therapies in Research Early Development , Novo Nordisk . . Vice President with more than 12 years of experience from working in the pharmaceutical industry . I have an in depth understanding of the pharmaceutical research development value chain from early target discovery and validation to handover to CMC and clinical development . I am highly experienced in applying a broad range of technology platforms to study , analyze and characterize peptide , protein and oligonucleotide based drugs for the treatment of diseases such as diabetes and obesity as well as cardiometabolic disorders . I have solid experience with project management of interdisciplinary projects and I have an excellent understanding of drug delivery technologies and physiological delivery routes . I am a very experienced leader and have a great ability for creating motivation , drive and positive energy that leads to high performing teams . I possess strong communication and presentation skills and I am highly experienced in initiating and driving collaborations with both academia and biotech external partners .. Technologies :

nucleic acids;peptides;proteins;small molecules;screening

Team Lead , Software and Bioinformatics . Manage a group of directly reporting full time employees including senior software engineer , software engineer and bioinformatician . Lead and perform strategic planning for software development , algorithm implementation and system architecture . Responsible for hiring , performance review and task allocation . . Technically proficient professional offering extensive experience in managing interdisciplinary teams and projects . Well versed in various programming languages . Practiced in bioinformatics , software engineering and product management . Comfortable serving as team lead or individual contributor .. Technologies :

Bioinformatics Scientist II . R D , variant biomarker discovery and detection , algorithm development , software development . My recent experience has been focused on all stages of the product development life cycle : from early conception and biomarker identification to algorithm development and clinical validation . I excel in small and large collaborative R D teams of molecular biologists , software engineers , and statisticians . My roles often involve model development , data analysis , data management , pipeline development , and software management . Software development experience ranges from quick prototyping to late stage software design and testing following ISO standards and compliance . My passion for discovery lives alongside enabling my teams to analyze and understand their own data . Creating low barrier tools with high data accessibility expands engagement , increases development , and enhances cooperation for all team members . Relevant Skills Proficient languages : Python , R , Perl , bash , PHP , SQL Intermediate languages : Java , C , MATLAB Sequencing : QC , alignment , bisulfite sequencing Microbiome : 16S , metagenomics , annotation Automated analysis pipeline reports Multivariate statistical analysis , regression , classification Model parameter optimization , data exploration Supervised unsupervised machine learning techniques Cluster computing , AWS Prototyping and ad hoc analysis . Technologies :

Head of R D Digital Technology in San Francisco . Lead the Digital Technology team responsible for the delivery of all Informatics IT products and services at three Pfizer R D sites in the San Francisco Bay Area . . Experienced Informatics IT leader in the biotech and pharmaceutical industry . Passionate about transforming people 's lives with innovative digital technologies .. Technologies :

Clinical Research Supervisor Protocol Project Manager . Pancreatic and Gastroesophageal Cancers Gastrointestinal Oncology , Helen Diller Family Comprehensive Cancer Center . I am on a mission to use my background in computational biology to make people 's lives better . It amazes me to think about the potential in applying today 's technological advances to a healthcare setting . The time I spent during my undergraduate career studying several areas of biology and the fundamentals of computer science has prepared me to tackle this challenge head on . I have been able to walk away from my four years of college with a variety of lab and analytical skills , the ability to learn quickly , and the motivation to always give my best effort . Knowing that I am making an impact on someone else 's future through my work is an exciting feeling . I am always ready to jump in to something new wherever my work takes me . When I 'm not at work , I 'm likely spending my time with my family , my turtle , or my camera . . Technologies :

Senior Scientist . . Highly experienced in gene to structure workflows X ray and cryo EM . Expertise in all facets of X ray crystallography . Highly experienced protein biochemist . Deep knowledge of protein structure and function . Skilled in a broad range of biochemical , spectroscopic and biophysical techniques . Track record in academic and industry based settings . Motivated leader of research and excellent team player . Superb communication skills .. Technologies : Xray;CryoEM

proteins;structure