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Research Chemist . . Experienced synthetic medicinal chemist . PhD , 32 step alkaloid synthesis . Postdocs include a 24 step polyketide synthesis . After transitioning to drug development in 2009 was heavily involved identifying and progressing DNDI 0690 to phase 1 clinical trials by synthesizing over 160 compounds over two year period . Currently designing and synthesizing various inhibitors and proteolysis targeting chimeras PROTACs for the Helmholtz Zentrum in Munich . . Technologies :

molecular glues;developing

Senior Scientist . . . Technologies :

Postdoctoral Fellow . Lipid effects on the voltage gated potassium channels . Structural and functional study of the macromolecular complexes by Cryo Electron Microscopy . Proficient with electrophysiological techniques : studying the lipid effect on the ion channels through patch clamp recording and planar lipid bilayer recording Proficient with structural biology : resolving the structure of macromolecular complexes by electron Cryo microscopy , single particle analysis and 3D reconstruction Combined multiple methods calcium imaging , capacitance measurement and carbon fiber electrode recording to investigate neurotransmitter release . Familiar with membrane protein expression and purification Experienced with molecular cloning , FPLC , PAGE , western blot , cell culture . Technologies : CryoEM

membrane proteins;structure

Physical Biochemistry Intern . Protein structure characterization via cryo EM including map and model building , refinement , and analysis . I am a PhD candidate training in biophysics . Specifically , I 'm interested in using cryo EM to study bacterial host phage interactions at the molecular level . During my training , I hope to better understand workflows and structure determination by cryo EM . In my previous research experience at NEIU , I used serial femtosecond x ray crystallography to study a red light photoreceptor , called bacteriophytochrome , from the soil bacteria Stigmatella aurantiaca . During this time I conducted experiments at Argonne National Laboratory Lemont , Illinois , SLAC National Accelerator Laboratory Menlo Park , California , and the Spring 8 Angstrom Compact free electron Laser Hyogo , Japan . My purpose is to build my scientific toolbox in order to better understand processes at the molecular and cellular level .. Technologies : Xray;CryoEM

proteins;interaction;structure

Research Scientist . Biochemist and Structural biologist . My research focuses on the study of molecular mechanisms involved in replication and pathogenesis of RNA viruses . Specifically , I use X ray crystallography and cryo electron microscopy in conjunction with RNA engineering to understand the structure and function of viral RNA elements in the context of virus infection . . . Technologies : Xray;CryoEM

nucleic acids;developing;structure

Field Application Scientist III . Working as an integral member of the Biopharma Team providing technical expertise to the Bio Rad sales organization and customers in the field . As a Biopharma Field Application Scientist , I serve as a critical liaison between Bio Rad and biopharma research customers , providing pre and post sale training and application support on our Proteomics portfolio of Next Generation Chromatography NGC , Western Blotting , Gel and Blot Imagers , and Bioplex instrumentation . I closely work with Field Sales Representatives and deliver trainings , presentations , product demonstrations and technical seminars to individuals and groups with diverse needs and experience levels . Primary Responsibilities : 1 . Live demonstration of our Proteomics portfolio instrumentation , software and consumables . 2 . Provide training on and assistance with data analysis , troubleshooting , and optimization for each of these technologies . 3 . Assist customers with experimental design , assay design , and reporting of results . . Life Sciences , Biotechnology R D Professional , MBA Candidate with extensive experience in managing projects , people , and operations in laboratory environments . Seeking a position to fully utilize steeped scientific background and merge with an MBA curriculum focused on Marketing and Strategy . Scientific Specialties : Assay Development , Virology , Immunology , Cancer Biology Research , Experiment Design in Life Science Molecular Biology , Biochemistry , Cell Biology , High Consequence Pathogens SARS CoV 2 , Ebola , Zika , Flu Specialties : Marketing , Strategy , Scientific Research , Data Analysis , Marketing Research , Project Management , Process Improvement , Product Development , Business Development Leadership : Team Building , Cross Functional Collaboration , Organizational Communications , Presentations Winner : Nano start up business plan competition with Latona Therapeutics , organized by the National Institute of Health and the Center of Advancing Innovation Technologies : MS Office Suite , Advanced Excel , R , Adobe Suite , Google Suite , GraphPad Prism , Tableau Languages : English Fluent , Hindi Fluent Bengali Native Please feel free to reach out to me at : nilanjan.mpb gmail.com . Technologies :

Research scientist . Study of viruses using cryo electron microscopy , X ray crystallography , and biochemical methods . Michael Rossmann lab . . . Technologies : Xray;CryoEM

proteins;structure

Senior Formulation Scientist . . I am an ambitious person who takes pride in succeeding in small as well as large tasks . My main area of expertise lies within protein stability and formulation and manufacturing of pharmaceuticals , food supplements and medical devices . More specifically , I have a PhD with focus on protein fibrillation and how proteins are stabilized by different plant extracts . During my PhD I obtained experience using fluorescence based plate reader assays , HPLC , SEC , DSC , ITC , CE , CD and FTIR as well as experimental design , analytical problem solving and scientific writing . Through my current position as product development scientist at Bifodan I have gained experience with GMP , project and stakeholder management , formulation of new and innovative dosage forms , acquisition and setup of new equipment , raw material characterization , process development , upscaling , change control , stability studies , preparation of technical and regulatory documents as well as insight in B2B sales , pricing and product launches . Last but not least , I recently concluded the education of occupational safety and a GMP course .. Technologies : ITC;DSC

biologics;characterization;formulation;stability

Senior Scientist . Leading a team with direct reports to manage multiple projects including designing and development along with conjugation , scale up , and transfer . Managing the development of QC , in process , and external controls for various products to the scale per CLSI guidelines . Responsible for designing of crucial V V studies per regulatory guidelines . Working cross departmentally to solve production and manufacturing problems by implementing conventional scientific knowledge to unconventional use thus significantly reducing the COGS . Managed outsourced antibody development and characterization while working with the vendors . . Driven professional with excellent scientific acumen and proven track record in the areas of Immunoassays , In Vitro Diagnostics IVD , and Bioassays towards New Product Development NPD within GLP and cGMP industrial , academic , clinical , and mixed environments . Up for a role involving leading and managing people towards solving scientific and business challenges . o Expert in leading scientific teams through supervision , mentorship , and motivation resulting in successful translation of concepts to products o Established in planning and managing the project phases from feasibility to development along with V V , scale up , and transfer o Strong Knowledge of FDA CE mark CLSI regulatory processes and associated compliance documentation o Hands on with Phase Gating and Design Control for new projects along with progress tracking , milestone delivery , and budgeting o Excellent understanding of Product life cycle that allows me to lead derisking via effective risk and gap analysis o Possess strong data analysis , troubleshooting problem solving CAPA , RCA skills o Expertise in managing multi partner collaborative interdisciplinary projects from Class I IVD medical devices including point of cares POCs to Class III high throughput multiplexed IVDs o Expert in cross departmental functioning due to strong interdisciplinarity in my training o Serving as a KOL in Immunoassay designing , development , verification , and validation o Engaged with market analysis industry o Excellent command on biological , chemical , physical , and engineering designing concepts o Expert in Point of care POC device prototyping and development including microfluidic Lab on a Chip and chromatographic Lateral Flow tools o Over 15 years of experience designing and developing direct and indirect Immunoassays in ELISA , Fluorescence FIA , Electrochemiluminescence ECL , Chemiluminescence CIA formats o Skilled in bioanalytical method development using Monoclonal , Polyclonal and other affinity reagents for the detection of low abundance soluble and surface protein biomarkers , DNA , glycans , small molecules , cytokines , and growth factors o Hands on with sophisticated tools like MSD , Protein Simple , BIAcore and techniques like bioconjugation , cell based bioassays , Anti Drug Antibody Assays ADAs , nano micro material designing and synthesis . Technologies :

antibodies;biologics;characterization;developing;screening

Associate Director , QA GMP . Antibody Drug Development QP Delegate Lead Auditor CMO , Quality Agreements Driving Changes , Stakeholder and CMO Management Cell Bank , Biological Intermediate , Drug Substance , Drug Product Review and Release IMP Certification to Clinical Trials Comparators and AMP PPQ QC , Method Qualification , OOS , Stability Expiry . Educated pharmacist M.Sc . in Pharmacy and GMP and ISO 9001 lead auditor with leadership skills and solid QA experience from working in Denmark and abroad . Experience in clinical and commercial manufacturing DS , DP , IMP and product release , process validation , facility and equipment qualification , and projects including tech transfer of new products from clinical to commercial manufacturing . Strong quality mindset and ability to work in and with Quality Management Systems . Key words : QP , cGMP , quality management system , change control , document control , CMO , lead auditor , deviations handling , validation , inspections .. Technologies :

antibodies;quality;stability

Research Investigator . Artificial intelligence , Machine learning , Computer Aided drug design CADD for drug discovery . I enjoy creating innovative tools and methods and am a good team player willing to add value to any research or business . I am a Kaggle Expert in data science competition https : www.kaggle.com tong2016 and have hands on data science experiences in : Machine learning , Deep Learning , Data analysis and Statistics , Database using Pytorch , Tensorflow , Keras , Scikit Learn , Pandas , SQL , Flask Also I have 20 years experience in computational chemistry and bioinformatics : Computational de novo antibody design , Artificial intelligence in drug discovery , computer aided drug design CADD , protein engineering and modeling , next generation sequencing data analysis , metagenomics using MOE , Schrodinger , Rosetta , Amber , Gromacs , SPAdes etc .. Technologies :

Post Doctoral Researcher Drug Discovery Chemistry . Synthesis of histone methyltransferase inhibitors especially against KMT9 10 and PROTACs as interesting mechanistic tools for cancer therapy in the Jung lab . . Technologies :

molecular glues;developing

Sr . Director , Oncology Bioinformatics . . Recognized leader in oncology bioinformatics and its application in drug development . Expertise in cancer next generation sequencing NGS , mutation detection and interpretation in cancer patients and their application in translational research .. Technologies :

Consultant on science and CFD trading . Assisted in developing a system for weighting vehicles in moving . Developed trading strategies for major indexes and currencies . . If you would like to get in touch , please drop me an e mail at n.damean yahoo.com more than 20 years research and development experience in industry and academics include : micro fluidics , micro droplets , micro and nano technologies and devices , biotechnologies , sensors and actuators , measurement techniques , heat management , automation and control , materials , optics , modelling and simulation , numerical methods , software programming . 10 years teaching experience in engineering mathematics , heat transfer and fluid flow , measurement science , automation and control . PhD Micro Systems , PhD Measurement and Control , MS Mathematics , MS Electrical Eng .. Technologies :

Associate Principal Scientist . Cell engineering Disease models and Cellular Models for drug screening and Protac validation Toxicological aspects of Cas9 expression : investigation in vitro and in vivo . . . Technologies :

Staff Scientist . Senior scientist , independently leading projects within area of expertise , supervising , coordinating , and training junior scientists BS MS PhD . Project lead : structural biology cryoEM of host viral RNA protein complexes involved in translation . Project lead : viral hijacking of host small RNA regulation . Project coordinator : structural biology of PIWI protein complexes . Supervised multiple technicians and postdocs in protein and RNA production , structural methods , and assay development in vitro cell culture . Acquired and analyzed data , generated models , presented at conferences . Established in vitro translation assays for viral reporter genomes using chemiluminescence and fluorescence in 384 well format . Tested effects on translation by small molecules , oligonucleotides , and RNA protein complexes . Established workflow for generation of viral RNA reporter genomes preparation of T7 RNA polymerase , in vitro transcription , purification of RNA genomes , assay development for translation in 384 well format . Used alpha fold to generate models for hypothesis generation . Developed biophysical and functional assays . Synthesized , purified , and evaluated bifunctional compounds targeting RNA in vitro in cell culture . . I use insights from structural and molecular virology to develop tools for RNA therapeutics , with a focus on non coding RNA and translation regulation . I am a passionate , driven , and curious RNA biologist , with solid expertise in integrating structural X ray crystallography and cryoEM and molecular biology with biochemical , biophysical , and cellular methods . I have managed and trained junior scientists in projects ranging from structural biology to cell biology , within academia and for industry collaborations . I have trained and led teams in a defense setting , and have a strong experience in coaching junior team leaders . I am experienced in teaching and curriculum development , and grant writing for research projects and resource allocation .. Technologies : Xray

proteins;structure

Academy Research Fellow . . During my research career , I have mastered several topics . I have developed efficient stochastic methods for modeling intracellular signaling and single cells , written extensive reviews about postsynaptic signal transduction models for synaptic plasticity as well as astrocyte and astrocyte neuron interaction models , implemented several models to test the reproducibility and comparability of the models , and developed models for neurons , astrocytes , and astrocyte neuron interactions especially related to synaptic plasticity and learning . I also grow oats , barley , and caraway at our family farm in Finland MTY Manninen Minna and Tiina .. Technologies :

Project Group Leader . . . Technologies : CryoEM

Head of Medicinal Chemistry . . Drug discovery chemist , team leader and project leader experienced in : Drug clinical candidate and PET tracer discovery Neuroscience and Oncology therapeutic area People leadership , coaching , mentoring , development Project leadership , matrix leadership , leading cross functional teams Hit lead generation and optimization SBDD and FBDD Synthetic chemistry Parallel medicinal chemistry automation Academic pharma partnerships Due diligences Challenging targets including protein protein interactions , enzymes , proteases , allosteric mechanisms Antibody drug conjugates Artificial Intelligence and Machine Learning applied to drug discovery Working with CRO 's worldwide Intranasal drug delivery research Patent writing . Technologies :

proteins;small molecules;interaction;screening

Cryo EM Specialist . . Working in the Simone Mattei Team at the Imaging Centre at EMBL Heidelberg as a Cryo EM Specialist providing cutting edge electron microscopy service to users . Previously , I 've worked in the Lab of James Hurley at UC Berkeley , USA , as an EMBO Postdoctoral Fellow using electron microscopy to get a structural and mechanistic understanding of how cells signal nutrient availability . I also implemented new hardware and software solutions that all users in the lab can make the most out of their data . During my scientific education , I 've learned electron microscopy in the Lab of Carsten Sachse at EMBL Heidelberg , Germany , during my PhD thesis and applied it to understand fundamentals of autophagy and to develop new data processing strategies . During my undergraduate studies which involved an 8 month master thesis , I employed NMR spectroscopy , isothermal titration calorimetry and in vitro assays to study aspects of mRNA degradation in the Lab of Remco Sprangers at the Max Planck Institute in T bingen , Germany .. Technologies : CryoEM;ITC;NMR

nucleic acids;structure

Graduate Research Assistant . . I am a structural biologist interested in investigating the intricate mechanism behind various enzymatic functions using cryo EM . My Ph.D. work is focused on studying the various aspects of replication fidelity of human mitochondrial DNA polymerase gamma . Specifically , I am studying the mechanisms behind 1 proofreading during DNA replication , 2 metal dependent translesion DNA synthesis , 3 long distance lesion recognition ' memory ' , and 4 drug interaction with nucleoside reverse transcriptase inhibitor NRTI . To date , I have one co first author and one co author publications .. Technologies : CryoEM

proteins;interaction;structure

Bioinformatics Scientist . . I bring a computational focus to the study of complex data generated in systems biology . I am passionate about generating concrete results in cancer biology , immunology , and DNA packaging by developing hands on algorithms that elucidate the structure of the complex networks underlying data . My background combines research in computational systems biology , applied statistics and the mathematics of high dimensional spaces . . Technologies :

Scientist . . Dedicated , enthusiastic , and committed scientist . I am a collaborative leader , driving innovation to develop bioanalytical and biophysical concepts . My priority is to work interdisciplinary , concerning a wide range of analytical techniques and the active interaction with outstanding scientists from different scientific areas and countries . I achieved extensive expertise in ; quantitative bioanalytical e.g. HPLC MS , flow cytometry , enzymatic activities , ELISA , immunogenicity , pharmacokinetics PK , and biophysical e.g. ITC , FTIR , and Fluorescence Spectroscopy assays . At BioAgilytix , we want to join our hands and expertise with your organization , to efficiently progress your innovation with the highest quality science .. Technologies : ITC

enzymes;proteins;characterization;interaction

Scientist . . Research scientist at the Swedish Defence Research Agency . Specialized in biochemistry and structural biology . Has been seen doing various flavours of bioinformatics and project management . Technologies :

proteins;structure

Research Fellow part time . Physiological analysis of membrane proteins in Dionaea muscipula . . Technologies :

Senior Scientist . DMPK . More than 12 years of academic and industry lab experiences ; Trained and skilled in molecular biology , protein production and purification , glycomodification of protein , drug discovery and rodent work ; 7 years of experience in monoclonal antibody generation from hybridomas , in vitro antibody effector function analyses , luminex and BLI operations , viral transduction and cell line generation ; strong problem solving and data analysis skills ; experienced in equipment operational trainings and presentations .. Technologies : BLI

antibodies;expression;interaction;screening

Professor . . My research focuses on understanding the formation of functional hierarchically structured materials in order to apply that understanding to make new materials . We use self assembly , driven by interactions between nanoscopic species micelles , nanoparticles , polymers in solution and at interfaces to form materials with organized structures from nm to cm . Understanding interactions between surfaces , nanoparticles and other species is central to our control over structure and thus function . We use time resolved grazing incidence X ray neutron reflectivity , liquid diffraction and small angle scattering to study formation mechanisms final structures . A range of other complementary techniques including TEM , SEM , AFM , NMR , light scattering , surface tension , conductivity , XRD , SESANS , USANS USAXS , gas adsorption are also used to characterise our materials across length scales from tens of ngstroms to microns . At present research areas in the group include self assembly in deep eutectic solvents , the impact of solvent structure on solvation and nanoparticle growth , gels and emulsions prepared using partially oxidised cellulose nanofibrils and their interactions with other biopolymers , novel bio derived surfactants , mesoporous inorganic materials and polymer stabilised lipid nanodiscs for membrane protein supports . Extensive collaborations with other groups in industry and academia apply the novel materials synthesised in our group to applications from delivery of active species , to catalysis and green gels or emulsions .. Technologies : Xray;SLS DLS;NMR

Postdoctoral Researcher . Structural Based Drug Design for corona enteroviruses proteases inhibitors and target protein degradation PROTACs . . Experienced Graduate Researcher with a demonstrated history of working in Protein Science . Skilled in X ray crystallography , Biophysics techniques , Structural Biology , Protein Purification , and Protein characterization . Strong research professional with a Doctor of Philosophy Ph.D. focused in Biochemistry , Biophysics , and Molecular Biology .. Technologies : Xray

molecular glues;proteins;developing;characterization;structure

Assistant Professor . . I work with proteins and their ligands , focused on studying their structural and functional relationship and characterising the atomic details of their interaction . The main tool for this has been NMR spectroscopy ; however , I have also worked with cryoEM , crystallography , protein ligand binding docking computer calculations , molecular modeling and isothermal titration calorimetry . My scientific interest lies within protein science and the discovery of the modus operandi of proteins . My research career has taken me through areas such as cancer and malaria research , RNA biology and studying the side effects from antibiotics . Specialties : Protein science , cancer research , RNA biology , malaria , structural biology , Quartz Crystal Microbalance binding kinetics , ITC , mass spectrometry .. Technologies : ITC;NMR

nucleic acids;proteins;small molecules;interaction;structure

Director , Bioinformatics Scientific Data Engineering . . Beginning as a molecular biologist at the Salk Institute , most of the last twenty years have been spent working in the pharmaceutical industry providing bioinformatics solutions for biologics drug development , most recently as Associate Director . Whether it was characterizing the soluble proteome at Bayer , or developing new antibody epitope prediction methods at Monogram Biosciences , or building a software development team that created multiple LIMS and cutting edge antibody sequence analysis programs at Xoma , significant impacts have been made at each organization by enhancing capabilities , increasing throughput and creating value . Most recently , work at Xoma was recognized by winning the BioIT World Best Practices Award in 2016 . Authored ten scientific publications , twelve major scientific abstracts and seven patent applications 3 issued . Experience includes hands on research , software and database development , bioinformatics analysis , interdisciplinary teamwork with biologists , business development and legal departments , and management of software development and bioinformatics teams . Strong experience in scientific software development in the areas of genetics , antibody and protein engineering , including next gen sequencing NGS and laboratory information management systems LIMS . Excels at analyzing complex situations and synthesizing new solutions to improve business processes and maximize use of technology . Enjoys the challenge of new scientific problems that allow leadership of a team of creative people to develop innovative solutions that deliver significant impact . Specialties : Python , R , PHP , Perl , HTML , SQL , Django , Jupyter , iPython , PostgreSQL , Oracle , MySQL , database architecture , software design , Accelrys DiscoveryStudio , SAMtools , Knime , MacOS , Linux , Windows , GitHub , protein modeling , antibody structure analysis , NGS , Next gen sequence analysis , Javascript , UI UX , HMMER , CLUSTALW , Biovia ELN . Technologies :

Associate Director Medical Affairs . . Associate Director , Medical affairs , solid tumors . Leading Nordic medical affairs team within solid tumors . Working mainly with a TROP2 targeted antibody drug conjugate in development for treatment of a variety of solid tumors .. Technologies :

Research Scientist I . . Chemistry Ph.D. with a demonstrated history of working in the chemicals industry . Skilled in protein expression , purification , and structure analysis using solid state NMR , Atomic Force Microscopy AFM , and cryogenic electron microscopy cryo EM . Experienced in elemental analysis using ICP MS and ICP OES .. Technologies : CryoEM;NMR

proteins;expression;structure

Senior Research Fellow . . . Technologies :

Scientist . . Highly motivated , productive and extensive experienced scientist with 15 years in cellular and molecular biology especially in two fields , signal transduction and protein modification including ubiquitination . Expertise on multiple levels : molecular biology techniques biochemistry , protein purification and in vitro enzyme assay , in vitro cell based techniques CRISPR Cas9 , signal transduction and light imaging and in vivo utilization of animal models . Demonstrated ability to lead and complete research project in timely manner . Flexible , collaborative , and dedicated team player interested in interdisciplinary approaches and with experience in multidisciplinary collaborations Specialities : Biochemistry , Cell Biology , Molecular Biology , Signal transduction , Genetic , Development Biology , Protein degradation . Technologies :

proteins;characterization

Chief Scientific Officer . . . Technologies :

Computational Biologist . . I am seeking new challenges at the interface between computing and biology that combine my interests in microelectronics and data analytics . My prior experience has been in the analysis of complex biological data . This includes microarray expression , genotyping SNP chips , protein expression , and assay qualification . Computational Biology is the field that can synthesize the vast amount of data and identify the patterns . Solving problems in today 's rapidly changing environment takes a team approach . I most recently led a group of computational biologists and an interdisciplinary group to identify biomarkers for oncology therapeutics . Specialties : Bioinformatics , data mining , statistical analysis , microarray analysis , sequence analysis , protein folding , computer programming C , Matlab , Java , and assay development and qualification .. Technologies :

Purification Academic . . I am an MSc in chemical engineering from DTU Chemistry with a special interest in computational chemistry and protein chemistry . I am currently working as a scientist at MipSalus ApS in the manufacture of a drug for PKU patients , where my primary focus is on chromatography and the purification of the drug . While studying , my focus was on computational chemistry , where I have participated in multiple research projects on protein stability using MD simulations . At MipSalus , I predominantly work in the laboratory , where I purify the drug . For this , I pack columns , study the affinity of functional groups regarding the drug , and I am in the process of upscaling the chromatography for production . Furthermore , I train new colleagues in chromatography and make protocols for various processes in the production of the drug . For the protocols , I perform literature studies on the theory giving new employees an overview of the processes and why those processes were chosen . On a daily basis , I perform data handling and analyze the results , and thoroughly document the findings . With my background as a computational chemist , I have managed to incorporate my programming skills in the laboratory by programming the pipetting robot to pipette viscous liquids . Words that describe me : independent , initiative , organized , determined , goal oriented , and always in pursuit of new knowledge . I am always looking for new opportunities and to further improve myself as a scientist . It is said about me that I am a good colleague and a fast learner . Special IT tools in which I have gained experience : Gromacs , Amber , Matlab , Python , Linux , Chimera , Pymol , VMD . Some of the essential scientific projects I have participated in while studying have been embossed by computational chemistry in the use of MD simulations , SAXS curve fitting , SAXS guided MD simulations , and enforced rotational MD simulations to examine protein stability , protein composition , and protein conformations . I have developed a manual on how to perform MD simulations and SAXS guided MD simulations using Gromacs for new students at DTU . I am acquainted with machine learning and its tools in Matlab . Keywords : Chromatography Laboratory chemist Computational chemist Protein chemist HPLC Agar plating Bioburden Up scaling Analysis and data handling Documentation Literature studies Programming RLBA Unicorn KTA Matlab Python Gromacs Amber Linux Pymol VMD MD simulations Protein stability Teaching Opentrons Pipetting robot Excel Buffer preparation Protocol SOP writing Manual writing and developing Dialysis Microscopy Resin . Technologies :

Junior Group Leader . Understanding the molecular mechanism of microbiome driven diseases using Cryo EM . . Technologies : CryoEM

structure

Bioinformatician . . I aspire to bring together knowledge and technical skills in chemistry , physics , informatics , and biology and apply them to systems which can benefit from an integrative approach . Currently focusing on research in Molecular biology . Exploration oriented , analytical , and thorough . Experienced in system optimization , automation , streamlining , and simplification , and forming models frameworks from first principles . Willing to work both on strategy and planning , or implementation . Passionate about education and personnel training . Extensive experience with protein expression and purification , protein crystallography , cryo EM , bioinformatics , data analysis , and common Molecular biology techniques . Additional direct experience with instrument maintenance and software development geared towards automation and digitization in Life Sciences .. Technologies : Xray;CryoEM

Senior laboratory Scientist . I am working as senior laboratory scientist at TATAA biocenter in Gothenburg . I am involved in performing various scientific projects using molecular biology tools : Nucleic acid isolation quality control qPCR performance data analysis NGS Next Generation Sequencing Supporting core facility customers . Welcome to my Profile Driven and energetic individual with a lifelong passion for scientific discovery . Ph.D. degree in molecular and cell biology , with 15 years of work expertise in life science area . Throughout my career , I acquired a diverse scientific expertise making it easy to engage in communication of cutting edge science , or serve as an interface between researchers and the public sector . My colleagues often describe me as social , professional , flexible , problem solving with good planning and organisational abilities , thus contributing to a happy atmosphere in the team Relevant Competences : Molecular biology and bioinformatics tools PCR methods RT PCR , qPCR Nucleic acid analysis , Fluorescence and confocal microscopy Molecular cloning and recombinant protein expression Biological membrane proteins , extracellular localization and function Genetic transformation of micro organisms and higher plants Plant microbe interaction Photosynthetic light reaction in plants and green organisms Abiotic stress in plants mechanisms and adaptations Laboratory Automation : Operation ; Maintenance ; Programming ; Configuration of robotic workstation and liquid handlers epMotion 5070 , Opentrons OT 2 , PIPETMAX Gilson ; Workflow Automation System , from sample preparation to assay setup Skills and expertise : Molecular Biology , Cell Biology and biphysics : PCR methods , performance and data analysis DNA , RNA extraction quantification , quality control Protein purification , quantification fluorescnce and Confocal Microscopy Photosynthesis specific methods : chlorophyll fluorescence , electrochromism , carbon fixation Bioinformatics and genetic engineering : Software applications : SnapGene , BLAST , ClustalW , Primers 3Plus , GenEx Molecular cloning recombinant protein expression Genetic transformation of bacteria , yeast and higher plants Cell culture and in vitro work : In vitro cell culture Microinjection of cRNA into oocytes Immunocytochemistry SDS PAGE Western Blot ELISA , Fragment analyzer Computer Skills : Microsoft Office Suite , Word processing , Data processing and Presentation software Image Processing Illustration and video editing software Knowledge in using languages html , CSS and JavaScript Thank you for visiting my profile and don t to contact me if you have any question Email : azeezbeebo gmail.com Cell phone : 4673 310 28 33 . Technologies :

Staff Research Associate 2 . Managed Dr. Andrew Sharabi s laboratory in the Department of Radiation Medicine and Applied Sciences within the Moores Cancer Center of UCSD Health . Investigated HPV oncoproteins using multiple computational biology methods , including sequence homology . Learning both Python and R. Managed laboratory databases of patient samples from multiple clinical trials , including a trial with seven other sister sites . Processed a variety of patient blood and solid tissue samples for these trials . Managed and irradiated multiple tumor types , cell lines , tissues , and materials for clients as manager and sole operator of the Radiation Medicine Shared Resource Facility in the Moores Cancer Center . Assumed management and sole operation in August 2021 . Operated both a Precision X Ray SmART stereotactic X Ray irradiator and a JL Shepherd and Co Cs 137 gamma irradiator . Full time , 40 hours week Promoted in April 2022 to Staff Research Associate 2 . Experienced Staff Research Associate with background in molecular biology . Currently interested in tumor immunology and bioinformatics computational biology . Proven management and supervisor experience across multiple positions . Oracle Financial Cloud , Microsoft Office , FlowJo , Prism , RStudio , Python , and Alphafold enthusiast . Sport climber , boulderer , and a previous climbing competition team coach .. Technologies : Xray

Senior Scientist , Computational Medicinal Chemist . . Alisha is an accomplished , self motivated Computational Chemist skilled at leveraging innovative tools such as virtual docking , machine learning , cheminformatics , and method evolution to accelerate the development of drugs that positively impact the lives of patients . She currently serves as a lead Computational Chemist for the Center for the Development of Therapeutics at the Broad Institute of Harvard and MIT , where she is responsible for managing up to three projects simultaneously . Alisha designs and computationally triages compounds using pharmacophore models , predicted ADMET properties , quantum mechanics , molecular dynamics , and QSAR models . She has also gained extensive experience partnering with structural biologists , chemists , protein scientists , and biophysicists , as well as practicing clinicians to advance transformative and challenging projects and achieve meaningful benchmarks . As a recognized expert across multiple computational chemistry platforms Schr dinger , MOE , Forge , Spark , Pipeline Pilot , and OpenEye , Alisha regularly collaborates with external computation groups to discuss , develop , and refine new computational methods . Across her professional and academic tenure , Alisha has been recognized with multiple grants and awards for excellence in research . Her strong work ethic , innovative mindset , and commitment to open collaboration , have also resulted in three first author academic publications .. Technologies :

Senior Research Scientist . . I am a research scientist with 14 years of research experience in computational structural biology with strong focus on protein design , docking , molecular simulations , bioinformatics as well as machine learning techniques . I am also well versed in protein biochemistry , highthroughput screening techniques and molecular biology . My technical skills include : Protein design and engineering Rosetta Molecular modeling and simulations Schrodinger , Modeller , Amber , CHARMM , GROMACS , NAMD Template based and template free docking Small molecule library screening and cheminformatics Molecular Biology Cloning , DNA and RNA purification , PCR Protein Engineering Expression Purification Bacterial , AKTA systems High throughput screening techniques Yeast surface display and FACS Biochemical Protein Characterization BLI , HPLC , CD , SAXS Cloning and library construction MiSeq NGS prep and analysis Data science and analytics Python , Shell , Perl , MATLAB , C , Fortran Bioinformatics . Technologies : BLI

proteins;characterization;engineering;interaction

Bioinformatics Scientist II . My role includes operations and development in the bioinformatics team Bioinformatics Operations Analyzes and refines business and user requirements , and to facilitate bioinformatics systems and software solutions through the entire software development lifecycle . Performs validation studies for bioinformatics software changes and compiles relevant documentations in accordance with Design Control process . Obtains deployment approvals from relevant stakeholders and determines deployment windows with stakeholders . Bioinformatics Development Analyzes requirements and sets up development plan Ensures development meet all product development criteria and quality control measures . Provides development report and technical report for each release Provides development and testing together with documentation to ensure changes meet designed functionalities . . I got my undergraduate degree in Computer Science and my Ph.D. in Molecular Biology . My Ph.D. thesis was focused on the data analysis generated by NGS from Illumina platform . I have a strong background in Illumina sequencing platform , from bench experience working with molecular biology techniques , to a substantial software development and data analysis experience in genomics . Technologies :

Wissenschaftlicher Mitarbeiter MedWiss . . Chemische Biologie Chemische Synthese von PROTACs f r humane und bakterielle Proteine Synthese zyklischer Peptide und niedermolekularer Wirkstoffe Instrumentelle Analytik GVP und Pharmakovigilanz . Technologies :

molecular glues;developing

Research Scientist . . I have long standing and comprehensive experience in practical work in laboratories , especially regarding protein engineering , purification and handling . I am specialised in spectroscopy particularly in nuclear magnetic resonance NMR and I am used to work with both bacterial and mammalian cells . During the last few years I have gained a lot of experience regarding the development of descriptive mathematical data models and writing corresponding data analysis programs . On top of that I have been in charge of a multitude of master and bachelor students whose projects I designed and supervised . Furthermore I have experience in teaching and communication of science and scientific concepts to peers and people without scientific background . . Technologies : NMR

proteins;characterization;expression

Research fellow . I am currently joining the Biomedical Engineering Department in a project called AI Neurology , aiming to develop a deployable software for Stroke . . I am a highly trained mathematician specialising in high performance scientific computing , the human brain network , machine learning and complex systems analysis looking for new challenges and opportunities in developing a new artificial intelligence technology .. Technologies :

Vice President , Cancer Immunology Immune Modulation . Drug discovery with the focus on innovative immune modulating concepts for the treatment of human diseases caused by a deregulated immune system , including cancer , chronic inflammation and autoimmune diseases . Approaches include small molecules , biotherapeutics , vaccines and oncolytic viruses . . . Technologies :

antibodies;biologics;small molecules;developing

Posdoctoral Researcher . Institute of Structural biology BNMRZ Biomolecular NMR spectroscopy . Researcher in Integrative structural biology with a main focus on NMR spectroscopy , but also using X rays , cryo EM and any techniques from biophysics . I am mainly interested in investigating protein conformational changes and protein protein interactions that underline biological functions .. Technologies : Xray;CryoEM;NMR

proteins;interaction;structure

Principal Scientist . Lead Discovery , Small Molecule Research , Therapeutic Modalities , Roche Pharma Research and Early Development pRED . . Technologies :

small molecules;interaction

Scientific Investigator Computational Biologist . Member of the Genetic Data Sciences Team since May 2020 . . I am an experienced bioinformatician data scientist who is passionate about delivering high quality data and informative analyses to colleagues . I love the challenge of using using complex algorithms to infer exciting insights and then to be able to shrink warp the results into easily understandable reports and pictures . I have been fortunate to work in some great institutes and with some great groups . This has varied from large software projects like Ensembl , to more intimate projects , working one on one with scientists and biologists . Both ends of the spectrum have their own challenges but this is what makes things interesting Either working one to one and many to many , still means that you must strive to make your work comprehensible to whatever audience . I 'm driven to make data analysis as clear and concise to biologists and scientists without a technical background . Equally providing technical advice to colleagues with a similar technical backgrounds to mine should also be clear and concise . While working in large institutes is great , working in great institutes is also bad because of silo mentalities . So one of my common memes in my various work places has been to get colleagues with different , but complementary skills , to talk to each other Coffee meet ups , short spot light presentations of a potted history of a person 's career and interests have been some of the tricks that I 've tried . Specialties : Computational genomics , Next Generation Sequence analysis , exome analysis , comparative genomics , DNA sequence analysis , Personalized cancer medicine , automated clinical document generation , data integration , data interpretation . Programming languages : Perl , R programming language , Bioconductor , Python . High performance compute clusters , computational pipeline development , Docker , algorithm integration , ad hoc bioinformatic solutions , algorithm development , database implementations , DAS , website design and implementation .. Technologies :

Machine Learning Scientist . . . Technologies :

Sr . Postdoc . Engineered developed a genetically encoded nanoantibody derived nanoparticle probes containing targeting module functional module . This probe can target proteins , DNA , or RNA in vivo and be used on fluorescence microscopy and electron microscopy , also potentially on Cryo EMT , MRI , X ray . This probe has multiple advantages over nanogold particle probes that are frequently used in EM imaging field . R D experiences in the establishment of a company IconOVir Contribute to design and establishing oncolytic adenovirus libraries and screen for synthetic adenoviruses that can specifically kill P53 or RB negative cancer cells , or specifically target cancer sites in multiple cancel animal models , et al . The work in the period resulted in one co inventor patent and two first author papers in preparation . . Hi everyone , Thanks for viewing my profile . Here are my summarised skills . Let me know if you are interested and I would be to very happy to share with you a few interesting stories . A strong background in synthetic biology , biomedical engineering viruses , cells , DNA , and proteins , biochemistry , cell biology , virology , and fluorescence microscopy . Get a challenging structure based nanoantibody VHH , or single chain antibody scFv engineering project to work . Expertise with molecular cloning techniques enzyme digestion ligation , Gibson assembly , In fusion cloning , Gateway cloning , Slic cloning , Golden Gate cloning , QuickChange site directed mutagenesis . Familiar with protein purification from E.coli and mammalian cells . Expertise in the protein charaterization native gel , SDS PAGE , and western blot . Expert with statistic data analysis ex : Prism and presentation power point . Excellent oral and written communication skills in english , multiple experiences of presentation in international conferences . An innovator with track record in molecular design of biologics , of creative and proactive approach to problem solving , and strong analytical skills . Strong track record of paper publications 6 first author papers and one invention patent . Love synthetic biology and biological engineering . A team worker that enjoys communicating with people and eagers to learn new techniques . R D experience in the early lab investigation stage of gene therapy company Iconovir oncolytic adenovirus engineering , library establishment , and mid high throughput cell level screening . Experienced in CRISPR , TALEN , PiggyBac gene editing . Familiar with lentivirus , retrovirus , adenovirus , AAV production . Skilled in studying protein protein interaction yeast two hybrid , epitope tagging co IP , endogenous protein co IP and protein DNA interactions CHIP , CHIP seq , EMSA . Experiences in Next generation sequencing NGS RNA seq , CHIP seq .. Technologies : Xray

antibodies;biologics;carriers;characterization

Senior Scientist . . Keltic Pharma Therapeutics is a spin out company based on the work of Professor Andrew Tobin , Andrew Jamieson , and Graeme Milligan . Located in the new Advanced Research Centre at the University of Glasgow , commercially headed by Dr Elaine Sullivan CEO , we are aiming to find the next generation lead anti malarial therapeutic . . By trade , I m a research scientist with sixteen years of academic and industrial experience . After post doc ing in both the US and UK , in 2017 I transitioned into industry where my focus has been in the drug discovery sector . . Previous placements include : the University of Aberdeen , Glasgow , and California , San Diego ; GlaxoSmithKline , BASF , Novabiotics , Commercial Microbiology , Scottish Water Solutions Bardon Aggregate , and the Medical Research Council Technology . I have contributed to 17 papers , published in journals including Nature , Communications Biology , FASEB and Molecular Pharmacology . . Areas of scientific expertise : . GPCRs , molecular pharmacology , biased signalling , BRET receptor characterisation assays , residence time and kinetic assessments ; small molecule and fragment screening from small scale target characterisation to HTS ; general assay development ; correcting failing and problematic assays ; enzyme and kinase assay development ; primary human and immortalised cell culture ; development and screening of assays using primary cells . . Technologies :

small molecules;interaction;screening

Senior scientist at Cryo EM Knowledge Hub . . . Technologies : CryoEM

Senior Formulation Scientist . Formulation development for pDNA drug candidates against virus infections and cancer . . 10 years of industrial experience in formulation development , method development and stability assessment General knowledge of biologic drug development and CMC process from discovery to IND submission Familiarity with USP , PhE and regulatory requirements for biologics Experience in writing Module 3 IND submission documentation Ability to lead , coach , develop and manage a team of scientists and technicians Experience in managing external collaborations with CRO CMO Innovative , with a passion for driving scientific excellence and a continuous improvement mind set Thorough knowledge of physico chemical properties of proteins and peptides including antibodies , which plays a critical role in formulation development and stability assessment 12 years academic experience in investigation of protein structure , stability , thermodynamics and intermolecular interactions Deep understanding of characterization methods for macromolecules and their applicability for stability investigation Technical know how of operation principles and capabilities of biophysical and analytical equipment Track record of scientific publications in peer reviewed journals . Technologies :

antibodies;biologics;formulation;quality;stability

Research Scientist . Specialized assay scientist in high through put screening team . Activity and Chemico physical stability testing . Development of custom substrates for highly specific performance screening . Data Science Python . . Assay scientist with key compentency in developing small scale model assays used for both high throughput and manual screening . Primarliy within protein and enzyme applications . Key personal qualities include curious , analytical pragmatic , structured and result oriented . Professionally trained and experienced in organic chemistry MSc and biophysics PhD .. Technologies :

enzymes;proteins;screening;stability

Director , UCL Advanced Research Computing Centre . I am Director of the Advanced Research Computing Centre at University College London . UCL ARC has a hybrid mission : to provide the computing , data , software and networking infrastructure and skills that empower computational science and digital scholarship across the university and its partners , and to deliver world leading research in digital research infrastructures and their application . . I am Director of the Centre for Advanced Research Computing at University College London . UCL ARC has a hybrid mission : to provide the computing , data , software and networking infrastructure and skills that empower computational science and digital scholarship across the university and its partners , and to deliver world leading research in digital research infrastructures and their application .. Technologies :

Associate Director , Principal Scientist Project Team Leader . Department of Drug Discovery Oncology Biology . Experienced and accomplished project team leader and research scientist in oncology drug discovery in the pharmaceutical biotech industry , with a solid track record of successfully translating small molecules from discovery into clinical development : . Project team leader with demonstrated ability to effectively lead and manage multi disciplinary research teams composed of PhD level scientists with various expertise on medicinal chemistry , structure based drug discovery , HTS screening , biochemical and cell based assay development , formulation , pharmacology , DMPK , toxicology , and translational medicine . Strong social and leadership skills , supervising others efficiently by providing value added feedback coaching , guidance , objective setting , and performance management to team members . Research scientist with in depth understanding of cancer biology , intracellular signaling and gene regulation pathways and with thorough know how in biochemistry , molecular cellular biology , and biomarker discovery validation to support innovative drug discovery and translational research of small molecules . Intellectually flexible with a diverse expertise working on kinase , kinesin and protein protein interaction inhibitors , as well as epigenetic regulators ; can quickly assimilate new subjects and techniques , identify key concepts , and solve problems creatively . Proven ability to successfully establish and coordinate international collaborations with various internal groups , and with external partners such as academic institutions and industries in US , EU , Japan and China . Hands on experience in filing Investigator Brochures , clinical protocols , and IND IMPD regulatory documentations , to support US FDA and EU EMEA approval for first in man clinical studies . Accomplished writer , editor , and public speaker , with a strong record of scientific achievements . Able to present complex material in a clear , concise , and persuasive manner . . Technologies :

proteins;small molecules;interaction;screening

Senior Director of Software and Computational Biology . . Quantapore is hiring .... Technologies :

Bioinformatics Scientist 2 . . Senior computational biologist and mathematician with a broad range of experience in high throughput , multi omics , high dimensional data analysis and mathematical modeling . My work is guided by questions on tumor oncogenesis and evolution , as well as host immune responses to viral infection . I am skilled in the analysis and interpretation of scRNA seq RNA seq WES WGS , with 3 years of supervisory experience and project management .. Technologies :

Associate Professor : Biomedical Engineering , Bioinformatics , Microbiology , NEIDL . We are an interdisciplinary lab at the interface of genomics , molecular biology , computational biology , electrical engineering , and technology development . We develop computational and high throughput experimental methods to study the systems biology of microbial organisms and translate the resulting knowledge into biomedical applications including biosensors and wearables . . Professor , scientist , engineer , and manager with 20 years experience working in both biotech and academia . Skilled in Computer Science , Bioinformatics , Genomics , Life Sciences , Molecular Biology , and Electrical and Biomedical Engineering .. Technologies :

Senior Scientist , Bioinformatician . . Established and highly motivated bioinformatics scientist with expertise in scientific programming , data analysis , protein engineering and structural bioinformatics ; harbors a strong passion for innovative research and creative problem solving . Computational Methods Software Engineering High throughput Data Analysis LIMS Platform Development Library Design Sequence targeted Drug Design Protein Engineering Structural Analysis and Modeling Sequence activity Analysis Multi disciplinary Teams Project Guidance and Management Specialities : PERL , C , SQL , data analysis pipelines . Technologies :

Scientific Technical Leader I . . I am interested in exploring new ways of adapting technology and business to the field of healthcare . ps . I do n't work in Software Engineering or Testing and request not to be approached for such roles .. Technologies :

Assistant Professor . . My lab studies the misfolded proteins and self propagating protein seeds of neurodegenerative diseases including Alzheimer s , chronic traumatic encephalopathy , and prion diseases . We use ultrasensitive diagnostic assays , cryo electron microscopy , cellular and animal models to understand the structural underpinnings and biological mechanisms that contribute to the formation and accumulation of neurodegenerative disease associated protein seeds .. Technologies : CryoEM

idps;structure

Senior Scientist . Senior research scientist within Global Biotherapeutic Technologies GBT department of Pfizer . Project work involves antibody generation , engineering and characterisation . . Specialties : Molecular Biology . Protein display and library technologies . Antibody engineering . Mammalian cell culture . Tissue sample manipulation vaccine production . In vitro and biosensor based assay development . Data analysis and interpretation . Report and manuscript preparation . Technologies : SPR

antibodies;characterization;engineering

Head of Electron Microscopy AFMB Marseille . . Specialties : Protein DNA X ray crystallography , Cryo electron microscopy , Structural and Molecular Biology . Technologies : Xray;CryoEM

nucleic acids;proteins;structure

Senior Scientist . Novel HSP90 inhibitor development for human prostate bladder cancer Work focused on the overexpression of Heat Shock 90 Protein Hsp90 in prostate bladder cancers and the development of novel Hsp90 inhibitors as chemo drug for cancer treatments Hsp90 recombinant protein purification using HPLC and FPLC Study the specific binding of the drugs to different isoforms of Hsp90 using FL spectrophotometry Perform cell based luciferase refolding assay , and determine the IC50 number of the Hsp90 inhibitors Immuno histochemical evaluation the anti proliferative and cytotoxic effects of Hsp90 inhibitors Quantify protein expression using Western blots UV Fluorescent probes Protein extraction and DNA isolation from drug treated cancer cells Tumor M2 PK : A Novel Urine Marker of Bladder Cancer Design and develop 96 well plate assay to investigate urine glucose values in diabetes patients Assess bladder cancer cell proliferation under differential glucose levels by hexosaminidase assay Perform Western blot and Blue native analysis for protein expression of PKM2 in cancer cells Study PKM2 dimer tetramer conversion and inhibition by Shikonin an anti cancer herb Develop , optimize and standardize ELISA to analyze PKM2 values in human urine sample of bladder cancer patients Techniques : Proteins purification by AKTA Xpress purification system GE Healthcare ; Intrinsic fluorescence measurements by a SprectraMax M5 Spectrophotometer ; Spectroscopic analysis of proteins and DNA using the CD , Nano Drop and BioTek Synergy HT systems ; Automated capillary electrophoresis and western blotting using Invitrogen E Base and iBlot ; Near Infrared Fluorescence western blot analysis using LiCor Odyssey system , Imaging and analysis of gels and westerns using the UVP Chemi Doc It Imager . PhD in Biophysical Chemistry area with over 13 years working experience Wide knowledge on protein related research , especially in purification , quantification and characterization Hands on experiences on a variety of analytical methods such as specific binding assays , Electrophoresis Western Blot , and ELISAs Expert on characterization of drug stability and in vitro drug activity test Excellent experiences on bioanalytical assay development , quantitative qualitative analysis of pharmaceutical products and biological samples Cell Culture , Protein extraction and RNA isolation , Plasmid Purification PCR and RT PCR , Transfections and infections on multiple cancer cells lines With expertise in HPLC , LC MS , FPLC , FTIR , FL , DLS , CD , UV Vis , DSC , TLC , and Cryo EM Execute multiple simultaneous projects that require creating study protocols , experimental design , updating SOPs , and planning timelines . Trains , coaches or mentors students in laboratory techniques and research projects . Extensive computer skills in data analysis and management Great ability to function well within multidisciplinary teams . Technologies : CryoEM;SLS DLS;DSC

biologics;small molecules;characterization;interaction

Scientist II . Method development , method validation , and sample analysis under GLP conditions for anti drug antibody assays , pharmacokinetics assays , and neutralizing antibody assays , serving clients in the pharmaceutical biotech industry . . PhD graduate from Rutgers University whose thesis project dealt with HIV 1 latency , where our lab worked to deduce the different molecular pathways involved in forming and maintaining the latent state , with the goal of searching for small molecule drugs that can reverse it . Currently a Scientist II at a contract research organization , where we serve the pharma biotech industry to analyze samples clinical and pre clinical to support their products ; much of our work deals with biologics . I 've worked to develop and validate methods under GLP conditions and used them to analyze samples . Technical Skills : Mammalian tissue culture , PBMC purification , lentiviral vector construction and production , PCR , qPCR , DNA RNA extraction and purification , transformation , transfection , luciferase based cell assays , plasmid preparation , ELISA , MSD , Watson LIMS . Technologies :

antibodies;biologics;quality

Scientific Review Officer . . I am a scientist , team leader , project manager and liaison with over 31 years of experience in the biomedical field . My credentials include a consistent track record in biomedical research planning and development of collaborative strategies , publication in top gear journals Science , Nature , PNAS , strong communication skills , and excellence in human relations , staff recruitment and retention . As liaison , I designed and implemented strategies where academic and corporate biomedical resources were effectively merged to ensure a successful and timely completion of collaborative projects . My research endeavors have taken me through multiple fields , from cancer biology to neuroscience neurodegenerative diseases , immunology immune synapse , inflammasome , virology HIV , Flock House Virus and cell biology integrins , GAP junctions , cadherins , catenins , Golgi apparatus and organelle behavior during mitosis , providing me with an excellent , broad view of biomedical research . The common thread between these different fields has always been structural and morphological work , using mid to high resolution imaging techniques light , electron and cryo , with emphasis on approaches to correlated light and EM cryo EM , along with molecular probes development , assessment and implementation to undercover novel mechanisms of action for key proteins and cellular elements . Of particular significance have been the seventeen years spent working at the National Center for Microscopy and Imaging Research UCSD , in close interaction with R.Y Tsien Nobel Prize for Chemistry , 2008 and his group . I m currently employed at Scintillon in San Diego where I continue to tackle projects in need for correlative light and electron microscopy , with particular emphasis on cryo electron microscopy and cryo electron tomography .. Technologies : CryoEM

proteins;structure

Development Regulatory Bioanalysis Research Scientist . Development validation of small large molecules peptides , free total proteins bio analytical methods by LC MS MS PK , ADA biomarkers . Preclinical and Clinical samples analysis by LC MS MS methods GLP environment . . Skillsand experience : MS MS HPLC , UPLC 2DLC quantitative analysis for small large molecules peptides proteins Development validation of LC MS MS methods GLP environment Development validation of hybrid LBA MS assays by Immuno Capture : free total antibody PK , targets biomarkers and Anti Drug Antibodies ADA measurement Scientific presentations Fr Eng Drawing : Adobe illustrator , Sketchup Bioanalysis of preclinical Clinical samples Identification by GC MS In Process Control Quality Control analysis . Technologies :

peptides;small molecules

Data Analytics Programme Manager . Manage R D cross functional projects in pet healthcare Provide technical leadership on experimental and RWE data analysis Statistics , IT Manage stakeholders across the different divisions Comms , Legal , R D . I am a data scientist working on the development and application of statistical and machine learning algorithms to gain insights from complex multidimensional data , with a particular focus on bioinformatics , healthcare data , and petcare data . I have a background in Computer Science B.Sc . and M.Sc . , applied Mathematics and Statistics Ph.D. , and computational biology bioinformatics . I have been working in collaborative teams composed of data scientists , machine learning researchers , engineers , physicists , biologists , mathematicians , and computer scientists to solve a variety of computational and statistical problems . I developed new computational methodologies and tools to investigate biological systems by analyzing a variety of data including expression data , networks , karyotypes , epidemiological data , healthcare data , and anatomical features . I have an extensive experience in programming , designing complex statistical pipelines , producing informative graphical visualizations , and building interactive interfaces to explore data .. Technologies :

Postdoctoral Research Associate . I am a postdoctoral research associate in the group of Dr Rivka Isaacson , based in the Department of Chemistry at King 's College London . My BBSRC funded project is being conducted in collaboration with Dr Amy Camp of Mount Holyoke , USA and Dr Marta Carroni at SciLifeLab , Sweden . Together we 're aiming to characterize novel proteins involved in the sporulation process of Bacillus subtilis . . I m a protein biochemist undertaking a postdoctoral research position based within the Department of Chemistry at King s College London . I have a PhD from the University of Liverpool where I used a variety of biophysical techniques , primarily NMR and TEM , to study alpha synuclein , a protein which plays a key role in Parkinson s disease . This has left me with a love of proteins and the suite of biophysical techniques used to study them , especially in the context of neurodegeneration . More generally , I am fascinated by the biochemical and biophysical underpinnings of disease . As part of my postdoctoral work I am now trying to harness these same biophysical techniques , whilst also developing new skills in cryo EM , to probe the 3D structure of several proteins involved in the process of spore formation in Bacillus subtilis . Over my scientific career thus far I have handled various types of proteins considered particularly challenging , including intrinsically disordered proteins IDPs , membrane proteins , and redox sensitive proteins . I thus have an awareness of some of the more unique aspects of their handling preparation e.g. ultracentrifugation , detergents , transient stable transfections , necessity of reducing agents etc . My key skills include : Recombinant protein expression E.coli , HEK 293 Protein purification Protein NMR 1Ds , HSQCs , WaterLOGSYs , NOESYs , COSYs , TOCSYs Transmission Electron Microscopy TEM Protein crystallography Circular dichroism Fluorescence assays e.g. thioflavin T Cell culture Western blotting Liquid scintillation counting In summary , I love proteins and enjoy working in convivial , multi disciplinary environments to understand them in greater detail .. Technologies : Xray;CryoEM;AUC;CD;NMR

idps;proteins;characterization;structure

Bioinformatics and Data Scientist . . Computational Biologist and Bioinformatician interested in tackling open questions at the frontier of cancer genomics and immunogenomics . See my google scholar page https : scholar.google.com citations user AAyVb8AAAAJ hl en oi ao for my list of peer reviewed publications .. Technologies :

Senior Director of Bioinformatics . . I am a bioinformatician and computational biologist with extensive experience working on type 2 diabetes mellitus , oncology , and multiple sclerosis . I graduated with my Ph.D. in Biomedical Engineering from Boston University in 2010 from the Computational Genomics Laboratory and worked in early and translational Oncology Research at the Novartis Institutes for Biomedical Research in Cambridge , MA , USA until March of 2015 . From March of 2015 until June of 2021 , I was employed at Verily formerly Google x Life Sciences . My responsibilities ran the gamut , but I was most recently the Technical Lead for Computational Biology in Verily formerly Google x Life Sciences , where I split my time between leading research and development of machine learning methods for life science data , writing and vetting analytics plans for various ongoing scientific studies , and together with the people manager of computational biology making sure team members are set up to succeed have positive impact . I was also the Scientific Lead on various internal studies within Verily looking to generate evidence and test specific hypotheses on cardiometabolic diseases such as type 2 diabetes mellitus using clinical and molecular data collected as part of Project Baseline . I 'm currently employed at PrognomiQ as the Director of Bioinformatics , where we are looking to deploy state of the art , high throughput and reproducible multi omics towards early detection and treatment of complex diseases . I enjoy strategizing and setting direction , but also getting my hands dirty writing and reviewing code , doing statistical analyses , generating and communicating reports , and mentoring growing junior colleagues . It 's been fun .. Technologies :

Wissenschaftlicher Mitarbeiter . . Cancer Selectivity Nanobodies PROTACs Exploring nano biotechnologies to gain cancer selective constructs . Technologies :

molecular glues;antibodies;developing

Associate Director . . Energetic and motivated computational chemist with extensive expertise in development and implementation of algorithms and tools for protein modeling and computer aided drug design . Experience of working with multi disciplinary teams including organic medicinal chemists , crystallographers , biologists and pharmacologists . Specialties : molecular modeling , protein engineering , development of biomolecular force fields , virtual ligand screening , docking , crystal structure prediction of complex organic compounds . Technologies :

Process Development Scientist II . . Experienced Protein Biochemist with 12 years of experience in protein structure function studies and characterization of challenging proteins . Established track record in molecular biology , cloning , protein purification , biophysical and functional characterization DLS , SPR , Spectroscopy , native MS , Western Blot , CD , structural characterization bioinformatics , X ray crystallography and cryo EM and Enzymology enzyme activity assay development . Experienced in working with soluble , membrane and membrane interacting proteins . Proven leadership qualities with experience in leading collaborative efforts , providing mentorship and training to students . Excellent communication skills .. Technologies : Xray;CryoEM;SLS DLS;SPR

enzymes;membrane proteins;proteins;characterization;interaction;structure

Postdoctoral fellow , group of P.Schultz , Department of Integrated Structural Biology . Structural studies of large molecular complexes involved in transcription initiation and repair by cryo EM microscopy . . . Technologies : CryoEM

peptides;proteins;structure

Principal Scientist . . RNA Structural Biology ; RNA Biochemistry , RNA Biology , and RNA protein Complex ; RNA targeted small molecule drug discovery ; Structure and Function of Telomeres and Telomerase ; In cell NMR and protein biophysics under physiologically relevant conditions . Specialties : Structural Biology , NMR , cryo EM , Computational Modeling Publications H index 16 ; citations 1800 are available on Google Scholar : https : scholar.google.com citations user eK iKd4AAAAJ hl en . Technologies : CryoEM;NMR

nucleic acids;proteins;interaction;structure

Senior Director , Head of Bioinformatics . Developing and deploying existing and new analyses and pipelines to engineer B cells using CRISPR for therapeutic use . . Currently working in a startup developing therapeutics based on B cell engineering . Engineered B cells can secrete proteins vital for addressing medical needs . Previously worked in a startup on developing new oncology drugs taking advantage of synthetic lethality , developing new analyses for genome wide CRISPR screens and mining publicly available cancer data . Worked on featured snippets , a part of Google 's search group . This is the box you see at the top when you type in a query like why is the sky blue . Most of this work is in C and Python . Principal developer of the open source software MolBioLib on SourceForge , that is a C 11 framework for rapid development of tools , particularly those related to bioinformatics . It has been used in 11 published papers , with several more papers pending . It was also used as the primary framework at Seres Therapeutics for their primary analysis pipeline . Experienced in microarray , Sanger , and next generation DNA RNA sequencing algorithm development , annotation , and amalgamation and analysis of multiple data sources including immunodeficiency causing variants , RNA Seq , RIP Seq , ChIP Seq , cDNA , chromosomal conformation , and bacterial 16S region . Experienced in large scale production software development , massively parallel systems , efficient methods of solving nonlinear time dependent PDEs , and nonlinear dynamical systems chaos theory . Specialties : C , algorithms , natural language processing , bioinformatics , microbiome , numerical analysis , finite element methods . Technologies :

Bioinformatics Specialist . 1 . Inventing new methodology for aligning cryo electron tomographic tilt series . 2 . Developing AreTomo , a multi threaded and multi GPU Linux application that fully automates the entire process from CTF correction , to tomographic tilt series alignment and reconstruction of 3D volumes . 3 . Developed MotionCor2 , a multi threaded and multi GPU Linux application that corrects electron beam induced sample motion . 13 licences have been issued to industrial users in 2018 including Pfizer and Amgen . 4 . Developed distributed multi GPU linux application for high thoughput electron tomographic reconstruction 5 . Developed a robust and efficient predicative data collection scheme for the acquisition of electron tomographic tilt series and implemented into UcsfTomo , a highly acclaimed windows application that enables full automation of tomographic data collection without human intervention . 6 . Routinely providing consultation to scholars not only at UCSF but also worldwide . . As an enthusiastic scientist and software developer , I endeavor to solve challenging data collection and image processing problems in cryo electron tomography cryoET and cryo electron microscopy cryoEM . My interest covers inventing new methodology , developing parallel algorithms , and implementing multi threaded and mult GPU CUDA applications . As the author of UCSFTomo and MotionCor2 , two highly acclaimed applications routinely used in cryoET and cryoEM , I am very proud of my work that helps so many people in cryoET and cryoEM communities . . Technologies : CryoEM

Research Tech III . Research and Development in collaboration with postdocs and graduate students Understand mechanisms of ebola glycoproteins , coronavirus spike glycoproteins and nucleocapsids by structural and functional studies under BSL2 conditions Perform the entire cycle of molecular cloning including primer design , PCR , plasmid preps and sequence verification for cloning viral structural proteins into different vector backbones . Study key residues in viral glycoproteins for neutralizing activity by mechanisms such as site directed mutagenesis . Express Ebola viral glycoproteins , coronavirus nucleocapsid proteins and antibodies from different expression systems including bacteria , insect and mammalian systems . Purify proteins using AKTA FPLC systems that employ affinity columns such as streptactin and proteinA , ion exchange columns such as monoQ and size exclusion Superose columns for applications such as cryoEM imaging and X ray crystallography . Make protein antibody and protein RNA complexes and isolate different oligomeric protein states using size exclusion chromatography Prepare , screen and optimize negative stain grids of protein complexes in a Titan Halo side entry electron microscope Freeze samples on grids under cryo conditions using the Vitrobot Setup data collection on Titan Halo using serialEM and EPU Process micrographs obtained from electron microscope to obtain 3D electron density maps Characterize binding activity of antibodies by ELISA and cell surface staining Determine IC50 of neutralizing antibodies by performing a pseudovirus neutralization assay . I am currently working as a Research Technician in Erica Ollmann Saphire lab at La Jolla Institute for Immunology LJI . My expertise lies in the field of molecular cloning and protein sciences . I have also gathered 2 yrs experience in the field of structural biology , mainly cryo EM and the use of electron microscopes . Prior to LJI , I was a research associate at Active Motif where I learnt to express , purify and validate antibodies for the commercial pipeline . I have 2 years hands on research experience in a molecular biology lab at UCR where I earned my masters degree with a thesis and 3 months of internship experience from Teco Diagnostics . I have an undergraduate degree in Electronics Engineering and 5 years work experience in software industry . My skill sets include : ELECTRON MICROSCOPY SKILLS Use , handle , transfer and store grids for negative stain and cryo . Make and optimize grid preparation for negative stain , screen grids and setup data collection in a Titan Halo side entry electron microscope CryoEM sample prep Clip grids for cryoTEM Process negative stain and cryo datasets to obtain low and high resolution electron density maps LABORATORY SKILLS Nucleic acid Molecular Cloning both restriction enzyme dependent and seamless Gibson cloning : Competent in the complete cloning cycle including techniques like primer design , PCR , DNA extraction , agarose gel electrophoresis and DNA sequence analysis Site directed mutagenesis Experience working with BioXp 3200 automated DNA fragments synthesis platform for synthesis of gene blocks RNA isolation by invitro transcription Protein Recombinant protein expression and purification from E. coli metal affinity based column chromatography , mammalian 293 T and CHO cells and insect systems Schneider S2 cells AKTA FPLC systems Use , maintain and troubleshoot Antibody digestion from IgG to Fabs for structural studies Centrifugal filters Amicon , vivaspin and zeba Pseudovirus neutralization assays Octet BLI SDS page gels , western blots , dot blots , immunoprecipitation FRET assays , MTS assays , ELISA , Luminex based assays SOFTWARE SKILLS Bioinformatics : BLAST , Chimera Software tools for cryoEM data analysis CISTEM , cryosparc Imaging : ImageJ , Imagelab Snapgene viewer , Chromas , VectorNTI , CLC Sequence Viewer , GraphPad Prism Filemaker database , LIMS Thermoscientific Cellnsight CX 5 SQL , python basic programming , bash scripting MS office : Word , Excel , Powerpoint . Technologies : Xray;CryoEM;BLI;FRET

proteins;characterization;structure

Principal Bioinformatics Workflow Developer . making analysis pipelines run harder , better , faster , stronger . I shout at genomes for money . Technologies :

Research Fellow . Using deep learning models to assist , simplify and streamline cryo electron microscopy data acquisition cryoRL and data processing MicAssess Leading the development of an easy to use and customizable web application for cryo EM data processing cryoHub Interested in developing 3D reconstruction algorithms in cryo EM . Using deep learning models to assist , simplify and streamline cryo electron microscopy data acquisition cryoRL and data processing MicAssess Leading the development of an easy to use and customizable web application for cryo EM data processing cryoHub Interested in developing 3D reconstruction algorithms for single particle cryo EM . Technologies : CryoEM

Scientist Structural Biologist . . I 'm a structural biologist for Loxo Oncology in Boulder , Colorado , interested in using X ray crystallography and cryo electron microscopy in combination with biochemical assays to probe the structure and function of medically relevant proteins .. Technologies : Xray;CryoEM

proteins;structure

Deputy Head of Computing . . . Technologies :

Senior Director , QSP . . I am a computational biologist with several years of experience in bioinformatics , computational structural and systems biology , and mathematical modelling . With my mathematical and bioinformatics background , I did my PhD at Cambridge University , where I investigated and made an evolutionary analysis of the local structural environment of amino acids , developed a method CRESCENDO to predict the functional sites of protein families and applied it in sequence structure homology recognition and protein protein docking . After my PhD , I worked at MRC NIMR , London , to carry out my postdoctoral research on de novo protein structure prediction , refinement and ranking of the predicted protein models based on the functional site potential . Following MRC NIMR , I worked at EMBL EBI , as a Project Leader for BioModels , a repository of mathematical models of biological biomedical systems . Currently , I am working at Certara as a Principal Scientist Quantitative Systems Pharmacology . . Technologies :

Postdoctoral Researcher . My current research is focused on functional and structural characterization of ribosomal complexes in mammals in healthy and cancer cells using mainly in vitro protein translation assays , fluorescence , microfludics and cryo electron microscopy . . Multidisciplinary Scientist with 9 year international experience in structural biology and biochemistry . My research interests were always focused on structure function relationship of macromolecules implicated in diseases malaria , colorectal cancer , heamatologic diseases . PhD in Structural Biology EU funded FP7 Marie Curie research network focused on pre clinical drug development for infectious diseases and MSc in Biophysics . Research areas : protein nucleic acids interactions , drug discovery , structural biology , colorectal cancer , parasitology Full professional competence in English , French and Polish .. Technologies : CryoEM

proteins;structure

Director Computer Science , SRI . Computer science innovation and research for long term positive impact . A list of scientific publications : http : scholar.google.com citations hl en user VMn7Ss0AAAAJ . Leading long term high impact research and development . Specialties : Information security , formal methods , computational biology , nanoelectronics Government research , value creation , management of innovation . Technologies :

Senior Scientist . . I am a Scientist with demonstrated work capacity in both translational and fundamental research . Energetic research professional with a Ph.D. degree in Biomedical Sciences and skills in Functional Genomics and Proteomics Research . Competent in applying Computational and Bioinformatics tools .. Technologies :

Microbiologist . . As a biotechnologist microbiologist I worked for several years in university research laboratories . However , I have also spent research work at research centers and public environmental protection agencies . Many years of extensive experience in development and validation of molecular biological assays , fascination with research , scientific analysis of experiments , performance of biochemical working methods , questions in biochemistry and molecular microbiology complete my professional domain . I have also experience with biophysical characterization of the nucleic acid binding and unwinding activity of protein , with analysis of their role within eukaryotic and prokaryotic genome . Currently I deal with molecular diagnostics in the medical field , with particular attention to COVID19 challenges .. Technologies :

nucleic acids;proteins;interaction

Associate Director , Bioinformatics and Data Science . . . Technologies :

Vice President . This area is fully embedded in early drug development turning scientific ideas into great drug discovery programmes to benefit the patients . We work across all NN indications and with multiple drug modalities . The area consists of six individual department representing centre of excellence capabilities within assay , analysis characterization . The Structure Interactions department uses a wide range of cutting edge SPR , ITC , X ray and cryo EM technology platforms to characterize the structure and binding properties of peptide and protein ligands The Screening Bioassay Technology department develops high throughput cellular and immunochemical assays to ensure high throughput screening of drug candidates by using various read out and advanced technical solutions . The team also provides insights spanning immunogenicity risk , cellular binding and uptake mechanism , absorption predictions by using advanced in vitro models . The Research Bioanalysis department quantifies biomarkers and peptide protein analogues from in vivo studies using automated immunoassays to aid firm PK PD understanding . The Discovery ADME department uses advanced LC MS platforms for bioanalysis and metabolism studies of plasma samples . The MS Characterization department uses state of the art LC MS platforms for the physicochemical characterization of new drug candidates including chemical stability , and impurity formation . The Analysis Separation department develops analytical separation and chromatographic analysis methods for drug candidate formulations and in process analysis . . I am heading Assay , Analysis and Characterization , an area in Research Early Development in NN . This area is fully embedded in early drug development turning scientific ideas into great drug discovery programmes to benefit the patients . We work across all NN indications and with multiple drug modalities . The area consists of six individual department 90 FTEs representing centre of excellence capabilities within assay , analysis characterization .. Technologies : Xray;CryoEM;ITC;SPR

peptides;proteins;small molecules;characterization;interaction;screening;structure

Senior Scientist . BIOLOGICAL DIVERSITY BY DESIGN Seres Therapeutics has built a proprietary discovery and design platform that enables us to understand the dysbiosis associated with specific diseases . PRODUCT PIPELINE We are developing a novel class of biological drugs designed to treat disease by restoring the function of a dysbiotic microbiome . CLINICAL TRIALS We have multiple active clinical studies to evaluate our microbiome therapy clinical candidates . . Experienced computational biologist with over a decade of expertise in next generation sequencing , expression analysis , comparative genomics , and systems biology . All views are my own .. Technologies :

Senior Staff Bioinformatics Scientist . . I am a computational scientist who specializes in microscopy , machine learning and computer vision problems . I have 8 years of experience in the biotechnology industry and provide leadership in informatics efforts to bring the sequencing platforms to market and 12 years working on image analysis problems I also have an extensive background in computer vision problems in cryo electron microscopy and machine learning problems in proteomics . I am an expert in C C , Python with expertise in multi threading , networking and vectorization . I have over 15 years of experience in software design , object oriented program and algorithm development . Specialties : Microscopy , computer vision , machine learning , microscopy , proteomics , C , C , Python and DNA sequencing .. Technologies : CryoEM

Graduate Research Assistant . Currently a graduate research assistant and PhD candidate at Iowa State University in the lab of Baoyu Stone Chen . I study structural biology and biochemistry of actin remodelers Wave and Wash , specializing in single particle cryo electron microscopy . . . Technologies : CryoEM

proteins;structure

Scientist Drug Product Process Development . . I 'm a Chemical Engineer with 6 years of experience in process development and scale up of pharmaceutical drug products . I am passionate about process engineering , product development and production management . My intellectual curiosity has always driven me to venture into various avenues for solving a problem . I aspire to create a unique and reputable image for me in my field of interest . Specific industries of interest : Pharmaceuticals FMCG Energy Experience : Deep expertise in development of long acting injectable , microspheres , nano suspensions and liposomes Have experience in batch execution in GMP facilities , equipment validation and qualification URS , FAT , IQ OQ PQ activities Extensively worked on process optimization of pharmaceutical unit operations using Quality by deisgn QbD based approach , mechanistic modelling and process analytical tools PAT like FBRM , SOPAT , and PVM Quantitative and analytical mind well suited to make strategic decisions in fast paced environment Assiduous , affable and enjoy collaborative teamwork Education : Master 's in Chemical Engineering Academic projects : Spatial temporal modelling of spin coating on flat patterned substrates Multiphase validation of granular flow in STAR CCM Adsorbed natural gas ANG canister assembly for vehicular transportation Specialties Modelling software ANSYS , Visimix , MATLAB , DynoChem , STAR CCM . Technologies :

Anne McLaren Research Fellow . A transitionary role that gives me the opportunity to start my own research group studying human microbial communities using bioinformatics , mathematics , and microbial culture . . I am an independent group leader at the University of Nottingham studying the human microbiome using computational methods . I am always interested in new collaborations and opportunities ; please contact me at fiona.whelan nottingham.ac.uk .. Technologies :

Bioinformatician . . After working in the field for 3 years as a bioinformatic scientist at Salgomed , I have decided to continue my education at TU Munich working to receive a master 's degree in informatics . I have a computer science degree specializing in bioinformatics from UC San Diego . My strengths include working at the command line and using python to analyze and generate complex biological data and networks . My goal is to continue to use my expertise in the bioinformatic field to aide and contribute to the growing research and enterprises surrounding medical diagnostics , and treatment . . Technologies :