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PHD Student . Birol Lab Single Molecule Biophysics probing Quantitative Neuroscience https : www.mdc berlin.de birol PhD project decipher initial molecular events and underlying mechanisms that drive alpha synuclein pathology and its contribution to early onset of neurodegenerative diseases utilising state of the art single molecule techniques correlative super resolution light and Cryo electron microscopy studying biophysical properties and dynamics of interactions between alpha synuclein and neuronal organellar membrane systems elucidating the role dys functional alpha synuclein membrane interactions have in inclusion body formation , hallmark of synucleinopathies like Parkinson 's Disease . . Technologies :

idps;interaction;structure

Scientist . . Highly motivated biochemist biophysicist with 12 years of research experience across a broad range of fields , with strong skills in leadership and multidisciplinary collaboration . I have worked in fast paced environments with very high standards for research quality , and with emphasis on creative problem solving . Research experience includes antibody engineering , protein RNA biochemistry , structural biology , biophysics , immunology and neuroscience .. Technologies :

antibodies;nucleic acids;proteins;engineering;interaction

Scientist . Department of In Vitro Biology Member of the In Vitro Biology Assay Development lab focusing on the development and validation of a wide array of in vitro assay protocols for a diverse client base that includes pharmaceutical and biotechnology companies . . Highly skilled research biologist with broad based drug discovery knowledge coupled with a strong desire to continue developing scientific capabilities . Major strengths include assay development , molecular biology and protein production . Additional experience encompasses immunobiology , biochemistry , enzyme kinetics and small rodent handling dosing . Proven ability to deliver products by maintaining focus on project requirements , timelines and priorities . Graduate of Wyatt s Light Scattering University LSU Training for Dynamic Light Scattering DLS systems in Santa Barbara , CA . POST GRADUATE COURSE WORK Advances in Molecular Biology University of Delaware Advanced Immunobiology Fairleigh Dickinson University Human Physiology I II Fairleigh Dickinson University Immunology Seton Hall University Biostatistics Seton Hall University . Technologies : SLS DLS

biologics;proteins;expression;screening

Scientist Computational Biologist . Design , develop , implement , and optimize computational core capabilities to illuminate the dark matter in plants . Lead , perform , analyze , and visualize discoveries for partnership progras . Computational biologist , statistical and probabilistic programmer , and software engineer who infers maximally accurate and precise probabilistic models to understand complex systems in biology . Passionate about developing and implementing technologies that lead to a healthier and more environmentally sustainable world .. Technologies :

Senior Scientist . . . Technologies :

PhD Candidate . PhD candidate at the institute of Biochemistry at Free University Berlin . Group of Prof. Dr. Markus Wahl and Dr. Bernhard Loll . Topic : Catalytic Understanding of Bioactive Enzymes . . PhD candidate of biochemistry at FU Berlin . Doing research at the institute of structural biochemistry . Highly interested in structural and functional biochemistry of biocatalytic enzymes . Cryo EM X ray . Technologies : Xray;CryoEM

enzymes;characterization;structure

Research Associate . Master 's thesis : PROTAC Synthesis , Cancer Drug Development Group . . Technologies :

molecular glues;developing

Senior Scientist . . I have worked professionally with protein purification and characterization since 1995 , and within the same area during my student years up to a Ph . D. 1993 focused on membrane proteins . During my years 1993 2000 at Pharmacia later Pharmacia Upjohn my focus was on purification and characterization of target proteins for pharmaceutical small molecules research and development Drug Discovery . Included was also activity assay development and structural studies . At Amersham Pharmacia GE Healthcare in Uppsala 2000 now I have been involved in several research and product development projects in the area of chromatographic protein purification and electrophoresis .. Technologies :

Principal Scientist . Medicinal chemistry for oncology and immuno oncology programs . . Medicinal chemist with expertise from hit to lead through lead optimization in multiple therapeutic areas oncology , neuroscience , and virology . Experienced in small molecule discovery as well as alternate modalities including antibody drug conjugates .. Technologies :

antibodies;small molecules

Graduate Research Assistant . Characterization and Design of Next Generation Battery Materials Yi Cui Group Developed novel electrochemical tools for characterizing Gibbs free energy and entropy of solvation in lithium battery electrolytes Developed a method to grow graphene on silicon anodes through thermal surface modification and characterized the SEI on graphene coating using cryo EM . . Technologies : CryoEM

Internal Science Portfolio Communications . . . Technologies : CryoEM

Fluid Biomarkers Specialist , Biobank Manager . Experimental Medicine . . . Fluid biomarker specialist in neurodegenerative diseases and CNS related disorders : I have work with fluid biomarkers for clinical trials , pre clinical research and translational medicine as well as with fluid biomarker discovery as diagnostic tool for neurodegenerative diseases . I have experience with analytical method development , context of use conceptualization for method development and collaboration with contract research organizations CROs . I have also experience with PK and ADA assays as well as GLP for biologics antibody and protein drugs . As Biobank Manager , I have gained experience with biobanking from international trials , writing of laboratory manuals and applications for ethical committees VEK .. Technologies :

Senior Principal Scientific Researcher . . Biological Electron Microscopy and Ultrastructural Pathology Applications : Characterization of Amyloid Fibrils Tau , Synuclein , Amyloid b Characterization and Identification of Pathogenic Viruses Influenza Virus , SARS Coronavirus , La Crosse Encephalitis Virus , Poliovirus , Varicella Zoster Virus and Herpes Simplex Virus Characterization of Nanoparticles Ultrastructural Pathology for Safety Assessment Various Tissues Correlated Fluorescence and Immunogold Localization of Drug Targets in Cells and Tissues Correlated Fluorescence and Immunogold Localization of Therapeutic Molecules in Cells and Tissues Methods and Techniques : Correlative Light and Electron Microscopy CLEM Freeze Substitution Processing of Cells and Tissues for CLEM Immunogold EM Tokuyasu Method Cryo Immunogold EM Biological Scanning Electron Microscopy Serial Section Array Scanning EM 3D EM Negative Staining EM Ultrastructural Interpretation 3D Reconstruction and Modeling . Technologies :

idps;proteins;structure

Development scientist . I primarily work on developing and upscaling downstream processes for proteins and peptides . Secondly I use python to automate my data analysis and develop new methods for optimising protein stability and purification . . As A PhD I have independently managed scientific projects , established international collaborations and performed state of the art research . I love learning new techniques and am driven by my desire for knowledge , which is why I prefer to engage in challenging projects . I have chosen to specialize in biochemical biophysical characterization of proteins , due to my inherent interest in this topic and have during my PhD worked on characterizing the structural features determining substrate specificity in microsomal cytochromes P450 . I have also been given the opportunity to perform a variety of teaching activities as well as outreach . Academic research has taught me how to : independently drive a project from initial idea to completion , engage both practical and theoretical problems using an analytical approach and to form successful collaborations . I now wish to apply my skills in a position where the outcome is more readily observable . . Technologies :

peptides;proteins;characterization

Associate Scientist . Working in selections technology . Speciality Yeast display . yeast staining , FACS , selection , binding assays . 6 years experience in biotechnology and Protein Biology . Technologies :

proteins;interaction

Postdoctoral Researcher . . Molecular and structural biologist specialized in membrane proteins and generating high affinity binders with a background in physical chemistry , chemical engineering , biophysics , biochemistry and protein engineering . Involved in multiple research projects in collaboration with both academic and industrial partners . Skilled in project conceptualization and design , construct design , protein expression and purification , protein protein and protein drug interaction analysis , as well as functional and structural analysis of membrane proteins . Comprehensive technical , engineering and laboratory skills .. Technologies :

membrane proteins;proteins;small molecules;engineering;expression;interaction;structure

Bioinformatician . . Skilled developer with over 14 years experience in both academic and commercial environments Fluent in several programming languages incl . Python , Bash , Java , statistics programs e.g. R and scientific libraries incl . BioPython , ggplot2 Familiar with the most commonly used computational environments OS , virtualisation including computation on high performance clusters Proven ability to adopt new technologies and solve complex problems analytically Successful communicator and teacher able to plan and execute workshops , lectures and scientific presentations to both specific and broad audiences . Technologies :

Postdoctoral Associate . Patapoutian and Ward Labs Research field : Structural basis of mechanosensation . Biochemist and structural biologist with 10 years of experience studying challenging membrane protein targets .. Technologies :

membrane proteins;structure

Reader in Software Engineering . . University Senior Lecturer in Software Engineering . Always on the lookout for interesting collaborations , especially with IT industry . Research interests : software engineering , model driven engineering , non functional properties , model optimisation , component based software engineering . Technologies :

Head Of Image based Screening Systems . Scientist at Lead Discovery Wuppertal . Leading a cell biological lab up to 3 TA with a focus on target ID , lead discovery and lead optimization , thereby supporting small molecule projects along the early drug discovery value chain . Lead the lead discovery activities on an ion channel project that lead to the achievement of a major pre clinical decision point for further lead optimization . Secured a highly competitive funding scheme for a cross divisional Bayer project for 2 years to explore advanced analytic approaches Machine Learning for analysis of high throughput screening data sets . Co leading the pharma part of project since Q4 2019 , which compromises a diverse team of data scientists , biologists and different business functions across 6 different sites . Responsible for communication with external partners , internal stakeholders and the upper management . Co responsible for the setup of imaging based technologies at Lead Discovery in Wuppertal with a focus on phenotyping through High Content Screening with a strong focus on collaboration with our digital functions . Strong collaborative approach as highlighted by the involvement in multiple collaborations , ranging from small start ups to larger alliances . Further , leveraging internal collaborations for setting up novel workstreams to explore novel targets or disease mechanisms , leading to multiple target proposals . Co leading a cross divisional life science community Crop Science , Pharma , Consumer Health with a focus on Advanced Microscopy Methods to explore novel techniques and network with external partners . Applying a broad method toolbox in research , including cell line development clonal isolation , genetic perturbations siRNA and CRISPR , different readout paradigms fluorescence , luminescence , imaging . Generation of big data sets for advanced analysis using custom written analysis routines in collaboration with data scientists . . Dedicated and interdisciplinary trained scientist with 4 year experience in preclinical R D at Bayer Pharma leading the novel department Image based Screening Systems at Lead Identification and Characterization since 2022 . In depth knowledge of applying an analytical mindset to drive forward preclinical small molecule drug discovery programs and expert knowledge in the areas of microscopy including High Content Screening and live cellular assay systems . Strong background in in vitro assays , novel technology and target exploration as well as disease mechanism understanding . Recognized leader as well as strong entrepreneurial and innovation mindset as demonstrated through acquisition of internal competitive research funding leading cross divisional cross functional groups . Strong communicator allowing efficient interactions with employees , management as well as internal and external collaboration partners CROs , academic , biotech .. Technologies :

Full Professor . The goal of the Fernandez Busnadiego lab is to unravel the structural basis of fundamental cellular mechanisms , as well as their alterations in human disease . To that end , we employ multidisciplinary approaches pivoting on state of the art cryo electron tomography see e.g. B uerlein et al . , Cell 2017 ; Guo et al . , Cell 2018 ; Collado et al . , bioRxiv 2019 . . Protein aggregates are often found in neuronal cells of patients suffering from neurodegenerative diseases such as Alzheimer 's or Parkinson 's . However , little is known about the morphological characteristics of these aggregates in their native environment . Our group seeks to understand the detailed structure and cellular interactions of protein aggregates within optimally preserved cells to gain insights into their mechanisms of toxicity . To that end we employ cryo electron tomography , a technique that allows 3D visualization of the cell interior at molecular resolution . More information at : http : www.biochem.mpg.de 4857860 06 neuro disease . Technologies : CryoEM

idps;interaction;structure

Senior Scientist . I work as a computational chemist with a focus on structure based approaches , supporting several drug design projects covering different therapeutic areas and modalities . . Computational chemist with a focus on structure based approaches . I 'm gaining industry experience in supporting drug design projects covering different therapeutic areas and modalities , spanning from early target assessment up to LI LO . I apply molecular modelling , core hopping , library enumeration , molecular dynamics , FEP calculations , machine learning , quantum mechanics , and QM ML methods , among others , where appropriate . I am a co author of several patents arising from my industry work . During my postdoc , I was awarded a Marie Curie Fellowship to carry out research in targeted protein degradation , and as a team , we presented the first X ray crystal structure of a PROTAC in ternary complex with an E3 ligase and a target protein .. Technologies : Xray

Postdoctoral Research Scientist . Structure function relationships for integral membrane proteins . . Most modern diseases are due to the deregulation of proteins function . To design inhibitors or drugs , it is crucial to gets detailed information on the folding structure , dynamics , and macromolecular interactions of interest proteins . Using the solution and solid state Nuclear Magnetic Resonance spectroscopy and a variety of complementary biophysical methods ITC , SPR , X ray , CD , I characterized various challenging proteins such as NDM 1 metalloprotein , CK MM more than 60kDa , Alpha Synuclein IDPs , TSPO membrane protein and Adhesin P1 fibrilar protein . These proteins are interesting therapeutic targets because involved in pathway regulation e.g. lysosomal pathway degradation , or in diseases e.g. dental caries formation , cancer , antibiotic resistance . My biochemistry skills allowed me to control each stage of the study : from DNA plasmid to functional studies , through protein production . . Technologies : Xray;ITC;SPR;NMR

membrane proteins;small molecules;characterization;interaction;structure

Senior Scientist , Computational Biology . . OBJECTIVE : In active search for a challenging opportunity in data analysis , data science , computational biology , bioinformatics , algorithm development , microfluidics , biotech areas . Research and development professional with expertise in designing data analysis algorithms , creating software prototypes , modeling complex systems . Multiindustry expertise including DNA mapping , synthetic biology , PCR based multiplexed assays , microfluidics . Proven ability to solve complex problems , to make sense of convoluted data . Expertise in statistical methods , strong knowledge of applied math . Exceptional analytical skills . Excellent self starter with high adaptability . Knowledge of machine learning , Bayesian analysis and other data analysis approaches . Specialties : Modeling of complex systems , Algorithm development , Data analysis , Machine learning , Bayesian analysis , Bioinformatics , Computational biology , Applied mathematics . Technologies :

PHD Fellow . Drug discovery , Cryo EM , TEM , structural biology , biochemistry , Molecular biology Cell work , Immunoassays , mouse models , CRISPR , . Jeg er en h rdt arbejdende , motiveret og organiseret person , med gode brede , tv rfaglige kompetencer indenfor natur og sundhedsvidenskab . Mit prim re vidensomr de ligger indenfor molekyl rbiologi , sygdomme p molekyl rt plan , proteomics , genetik og cellebiologi og jeg har praktisk erfaring fra den biomedicinske forskning . Jeg trives i et udfordrende milj og med komplicerede opgaver , med fokus p kvalitet og faglighed . Jeg nsker et arbejdsmilj fokuseret p effektivitet , men med plads til humor , teamwork og kollegaskab . Desuden har jeg erfaring med undervisning , forskning og en udvidet international forst else . Disse kvalifikationer har jeg opn et igennem mine studier p Aarhus Universitet , som kandidat og bachelorstuderende , studenterunderviser og som udvekslingsstuderende p University of California San Diego samt gennem min praktiske forskning og laboratoriearbejde i et internationalt anerkendt laboratorie i USA , samt Danmark . Yderemere har jeg en baggrund som salgsassistent , hvilket giver mig en forst else for kommunikation , salg og service . N gleord : Cand.scient , molekyl rbiologi , project management , biomedicine , proteomics , genetics , bioteknologi , molekyl r medicin , projektstyring , molecular biology , histology , cell biology , laboratorie . Technologies : CryoEM

proteins;structure

Manager Bioinformatics Data Science . . . Technologies :

Senior Research Scientist . PROTAC Toolbox Chemistry Lead Senior Research Scientist SRS with dual responsibilities in the teams of FBLG PROTACs and iLAB within the Discovery Sciences department . Responsible for a company wide automated synthetic chemistry platform build in PROTACs . Professional Committee Membership : Organising member of the Gothenburg Friday Chemistry Seminar Series Dec 2020 present Discovery Sciences Employee Ambassador Nov 2020 present Chemistry Lab Forum Representative Sep 2019 Feb 2022 . Organic and bio organic chemistry researcher Methodical , organised and enthusiastic chemistry researcher with a passion for delivering scientific solutions to challening problems . Skilled chemist with unique combination of organic synthesis , API development and peptide chemistry . Excellent oral communication and presentation skills experience of producing oral and poster presentations at national and international conferences Experience of working in cGMP environments . Experience in the use of automated solid phase peptide synthesiser to produce of library of peptides . In depth experience of analytical techniques : 1D and 2D NMR , LCMS , HPLC normal and reverse phase , XRPD , IR and polarimetry . PC proficient in : Microsoft Office , ChemDraw , Reaxys , SciFinder , electronic laboratory notebooks and various NMR processing software e.g. ACD Labs , MestReNova , Spinworks , WinNMR and Topspin .. Technologies : NMR

molecular glues;peptides;developing

Senior Principal Scientist . . . Technologies :

Postdoctoral Researcher . . Postdoctoral Researcher in the Cell Biology department at the University of Texas Southwestern Medical Center . I earned my Ph.D. in Biochemistry and Molecular Biology at Michigan State University , where I studied bacteriophages and giant viruses . My current research focuses on the structural changes that occur during virus host interaction through the use of in situ structural biology techniques , including cryo focused ion beam milling , cryo correlated light and electron microscopy , cryo electron tomography , and subtomogram averaging . I have experience in protein expression and purification , cell culture , virus culture , and standard biochemical and molecular biology techniques . In addition , I have experience writing grants and scientific manuscripts . I am a big proponent of scientific outreach , and during my Ph.D. , I helped establish an ongoing outreach program between MSU and a high school in Lincoln , Nebraska .. Technologies : CryoEM

proteins;expression;structure

Senior Bioinformatics Engineer . . . Technologies :

Senior Bioinformatics Scientist . . Computational biology specialist with a broad array of skills . Diverse programming and scripting experience in Perl , Python , C , C , php , R , etc .. Adept in High Performance Computing environments , from advanced usage to cluster design and installation . Database and web development design . Hands on genomic level experimental design and lab experience . Specialties : Programming , Server Architechure , Statistics , Biology . Technologies :

Senior Scientist Chemistry . Synthesis of novel drug DNA conjugates for various protein targets using on DNA and off DNA chemical reactions , followed by their purification HPLC and characterization LC MS . Implementation of novel therapeutical approaches in DNA encoded chemical library technology DELT . Optimization of DEL selection process on multiple protein targets . Management of multiple projects in a dynamic and efficient manner . Drug discovery oriented scientist with 7 years of experience in synthetic organic chemistry methods and analytical tools and extensive knowledge of manipulating small , large , and conjugated molecules , leading to the successful generation of DNA encoded chemical libraries , membrane mimetic systems , and drug candidates . Technologies :

small molecules;developing

ISSF research fellow . I was awarded this short fellowship to continue and expand upon the research undertaken during my PhD. My research is mainly concerned with developing novel state of the art neural network architectures for self supervised learning of immune receptor repertoire sequence data , as well as developing HPC based immunoinformatics tools . . I am currently a Wellcome Trust ISSF fellow at the ISMB working on development of novel deep learning approaches , including self supervised learning , knowledge distillation and transfer learning , to be used in immune repertoire research . During my PhD I developed novel deep neural network models , to analyse ultra high throughput sequencing data , for systems understanding of convergence in immunoglobulin repertoires at the population level . My past experiences , at the BSc and MSc levels , are primarily in computational and statistical approaches applied to evolutionary genomics and phylogenetics . I have applied these skills to various microbiology research projects I was involved with over the course of my undergraduate and Master 's degrees . As an evolutionary and systems biologist by training , I am interested in utilising systems approaches for discovering general principles underlying the complexity of biological systems , in particular , by using large omics datasets .. Technologies :

Weed Control Chemistry Lead . LifeScience Chemistry . Innovation Data Science . Collaborations . LifeScience Technologies New Modalities . Functional Excellence Chemistry . Specialties : Medicinal LifeScience Chemistry . Protein Degraders Protacs , Molecular Glues . Proteases . GPCRs . Kinases . Fragment Based Drug Discovery , DELT Screens . Parallel Synthesis . Solid Phase Synthesis . Technologies :

membrane proteins;molecular glues;proteins;screening

Senior Research Scientist . Formulation development of peptide and protein drugs . . Technologies :

peptides;proteins;formulation

Head of genomics services . . . Technologies :

Postdoctoral Scholar . I have continued my research in the field of group II intron structural biology in the lab of Dr. Navtej Toor . My work has transitioned to cryo Electron Microscopy , which I am using to determine the structures of RNA protein complexes . . . Technologies : CryoEM

nucleic acids;proteins;interaction;structure

Associate Scientist . Topic : argenx develops novel human antibody medicines to unlock novel complex targets addressing diseases that are underserved by current therapies . Development , optimization and selection for the clinic of the lead Antibodies generates from the ArgenX plateform . Scientific support to the project including the redaction of scientific reports , patent and regular presentation of the project updates to the team and collaborators . Participation to the redaction of scientific publications Science , 2019 and patents . Development and optimization of new bioassay . CROs management and communication to collaborators . . Techniques used : Library construction , phage display , ELISA , MSD , SPR T3000 T200 , BLI Octet Red96 , antibodies production and optimization HIS engineering , germlining , liabilities correction , flow cytometry Fortessa X20 and cellular assays . Others : . Organisation of internal communication events academy . Electronical Labnote Book responsible : Daily support of ELN users , training and optimization of the system . Training and onboarding of new colleagues . Software used : GraphPad , BIA evaluation , Flowing software , FlowJo , Clone Manager , Octet softwares , . Dynamic scientist with more than 8 years of experience in the fields of Immunology and Molecular Biology . Since the obtention of my master 's degree , I first studied the role of the CD27 CD70 signalling pathway before joining Ablynx Sanofi in 2014 , where I was responsible for the Nanobodies screening and selection of the drug candidates . Since 2016 , I have been working at argenx , where I first had the opportunity to generate , characterize lead molecules and select the most promising candidates for the clinic through in vitro and in vivo studies POC , PK and PD studies . Since 2019 I am involved in the technical , scientific support and management of early discovery projects . COMPETENCES . Antibodies engineering : . More than 8 years of experience in the generation , screening and selection of lead human antibodies or VHH against evaluated targets . Broad Technical skills : . From library construction , phage display , screening and characterization SPR , flow cytometry , engineering , stability studies , PK and PD evaluation up to lead nomination . Collaboraors management : . Management and supervision of collaborators and CROs , discussion with KOLs . Trainings : . Training of new comers , team members 6 in total and supervision of student . Reporting : . Writing of scientific publications Persson EK , Science,2019 and Van De Walle I , J Allergy Clin Immunol , 2021 , patent applications and internal reports . TECHNICAL SKILLS . Library construction scFv , Fab and VHH , selection via phage display , production and purification of pre lead molecules in bacteria and mammalian cells Transfection , Purification . PK PD studies , including detection of ADA immunogenicity . Antibody VHH engineering , including pH dependency Histidine engineering , mutagenesis liabilities removal and germlining of pre lead molecules Library approach and CDRs grafting . Establishment and optimization of protein and cell based assays , including ELISA MSD , SPR , BLI , FACS , PK , PD , T cell activation and proliferation assay . Cell culture , PBMC isolation , cells purification . TRANSVERSAL SKILLS . Presentation of project updates and results to the team and external collaborators . Organization and management of the activities with the collaborators Universities , CRO . Redaction of scientific reports , Patents PCT filling and Publications Persson EK , Science,2019 and Van De Walle I , J Allergy Clin Immunol , 2021 . Supervision , training and onboarding of students and junior Research Associates . Organization of internal communication events R D day and academy events . Technologies : BLI;SPR

antibodies;characterization;developing;interaction

Principal Scientist . . I am a highly trained medicinal chemist . Currently I am a Principal Scientist at Halda Therapeutics OpCo . Prior to this position I was a Research Assistant Professor at the Icahn School of Medicine at Mount Sinai ISMMS . I have a Ph.D. in Medicinal Chemistry and have completed several years of postdoctoral training . My primary research goal has been small molecule drug discovery . I have also interned at Mount Sinai Innovation Partners : the technology transfer office for ISMMS and understand the key points required to commercialize a technology . . Technologies :

small molecules

Director , Computational Biology , Clinical Biomarkers Diagnostics . Support Amgen clinical trials in Oncology , Inflammation and Cardiovascular disease through Precision Medicine Bioinformatics and Computational Biology Lead functional team and support cross functional product development through collaboration , communication , technology development and provision of clinical and translational data insights Support the formulation and execution of biomarker and diagnostic development through fit for purpose computational and statistical analyses Development and custodianship of the precision medicine data platform , serving as the central data system for biomarker and omics data across all Amgen clinical trials Development and application of novel and fit for purpose AI ML methods and predictive analytics in the context of generation of clinical and translational data insights supporting Amgen clinical trials and internal translational analyses Collaborative formulation of standards for biomarker and omics data , cross functional governance models for accessing data associated with Amgen clinical trials Working cross functionally with clinical teams , data management , biostatistics , medical and therapeutic area functions Contributing to external publications , abstracts , communications and discussions with KOLs Leadership , team building and cultivation of positive work culture . . Technologies :

Principal Scientist Medicinal Chemisrty . . Chronic and incurable diseases affect approximately 133 million Americans , representing about 40 of the total population of the country . Common diseases like cancer , diabetes , stroke , mental illness etc . are responsible for 1.3 trillion lost economic output annually . Can we fight back to improve the situation Can we strengthen our economy through a healthier and efficient nation I am a synthetic organic chemist . I am passionate about it as it provides me a broad platform and scope to discover drugs for many common and uncommon diseases . Vast application of organic chemistry creates an opportunity to explore interdisciplinary fields and I am excited to explore the unique opportunity organic chemistry gifts me everyday . Interests : Medicinal Chemistry , Process Chemistry , Small Molecule Drug Discovery . Expertise and Technical Skill : Multi step organic synthesis Natural product synthesis Method development Organometallic chemistry Computational chemistry Small molecule purification and characterization NMR spectroscopy LC MS Mass spectrometry FT IR and UV spectroscopy Gas chromatography HPLC Biotage Microwave reactor Schlenk and Glove box Scifinder and Reaxys search . Technologies : NMR

small molecules;developing

Privatdozent . Privatdozent in structural and molecular biology of gene regulation and signalling , method development in structural biology , X ray crystallography , NMR and cryo EM . Lecturing of structural methods and biochemistry at BSc and MSc level . Researcher and academic lecturer in structural biology and biochemistry Field of special interest : information processing in biomolecular logic circuits Technical portfolio : structural and molecular biology , biochemistry , biomolecular X ray crystallography , cryo electron microscopy , solution and solid state NMR , bioinformatics , chemometrics , biophysics , protein expression and purification methods . Technologies : Xray;CryoEM;NMR

proteins;structure

Senior Scientist Synthetic Medicinal Chemistry . Delivery of lead compounds small molecules and PROTACs for the treatment of chronic respiratory diseases within the Early Respiratory and Immunology department . Development of synthetic protocols for the generation of pharmacologically relevant scaffolds in drug discovery . . Dedicated chemist with four years of postdoctoral research and two years of industrial experience in synthetic organic chemistry , medicinal chemistry and quantum mechanical calculations . Well prepared to contribute to a high throughput , challenging environment with focus on drug discovery to cure severe diseases , and synthetic method development for medicinal applications . Laboratory experience in stereoselective synthesis of natural compounds , bioactive small molecules and PROTACs . Comprehensive knowledge in drug discovery lead generation and lead optimization , metal , organo and biocatalysis , rational catalyst design , and isotope labelling strategies for mechanistic analyses . Solid foundation of modern laboratory methods and techniques . Expertize in DFT and post Hartree Fock calculations for reaction pathway simulations and physicochemical property calculations of molecules .. Technologies :

molecular glues;developing

. . MPhil candidate in Biochemistry . Passionate and self motivating in learning more knowledge about cryo electron microscopy cryo EM and Cryo ET . Interested in structural biology and relate protein functions to cellular events .. Technologies : CryoEM

proteins;structure

Computational Biologist . . I m an experimental protein biochemist biophysicist with a growing interest in computational protein prediction design . I have strong expertise in characterizing protein structure and dynamics for drug discovery using a broad range of structural biology tools , including cryogenic electron microscopy cryo EM , liquid state nuclear magnetic resonance NMR , X ray crystallography , molecular dynamics MD simulations , and mass spectrometry MS . I am proficient at determining protein ligand and protein protein interactions using microscale thermophoresis MST , fluorescence polarization FP , and hydrogen deuterium exchange MS . I am also adept at protein characterization tools such as circular dichroism CD and multi angle light scattering MALS . Additionally , I have over 12 years of experience in molecular cloning , protein expression , and protein purification using affinity chromatography , ion exchange chromatography IEC , and size exclusion chromatography SEC . Furthermore , I have experience in bioinformatics , machine learning , UNIX command line , Python , MATLAB , Mathematica , R , and C .. Technologies : Xray;CryoEM;SLS DLS;MST;CD;NMR;FP

proteins;small molecules;characterization;expression;interaction;structure

Scientist II Structural Biology CryoEM . Responsible for establishing an internal cryoEM facility . Maintain resources , develop and improve high throughput single particle EM workflows . Set up and optimized in house computational resources for efficient data analysis . Staying current with the developments in the field and initialize resource upgrades to achieve higher resolutions and throughput . Work closely with colleagues on training and company relevant structural biology projects . . Structural biologist and microscopist with passion for facility design , throughput optimization , and training . Excited to apply cryo electron microscopy , tomography , microED , and single particle methods to study structure and function of challenging proteins and complexes .. Technologies : CryoEM

proteins;structure

Head of Bioinformatics and Software . Head of Bioinformatics , Computational Biology , Data Analysis , Software Infrastructure , Database Architecture and Algorithm Development for a single cell sequencing NGS platform . Also assisting the CEO and CSO with scientific strategy and direction . Responsibilities include : 1 . Development and maintenance of on premise and cloud compute infrastructure and resources . Currently using AWS for our backend cloud native infrastructure , leveraging tools such as AWS Batch , RDS , DocumentDB , ECR . Code base is mostly Python and some SQL scripts . Using Jupyter and Plotly Dash for front end . Built REST API layer for server client communication over HTTP . 2 . Bioinformatics data analysis assay QC , genome alignment , structural variant calling and analysis . Currently using bioinformatics tools such as FastQC , BWA , BEDtools , Picard tools , SAMtools , BCFtools , Varscan2 , EBCall , Mutect2 , GATK , UCSC tools . These have all been containerized for modular use . Container deployment , runtime and management is handled by AWS Batch and Docker . Workflow is handled using Jupyter notebooks and Boto3 . Exploratory data analysis using Jupyter notebooks and RStudio . 3 . Research and development on new biological assays for high resolution cancer diagnostics . 4 . Development of data abstraction layer that interfaces with front end and back end resources . Currently using R , Python , SQLAlchemy , PyMongo , Boto3 . 5 . Development of our LIMS database and inventory experiment workflow management . Currently using MySQL as our relational database and MongoDB as our NoSQL database store . 6 . Management of Continuous Integration Continuous Development CI CD environment using Bitbucket Pipelines and CodeBuild , and version control using Bitbucket . 7 . Project management using JIRA Atlassian . 8 . Algorithm development graph based methods for clustering . . Leader and expert in bioinformatics and cloud computing infrastructure for biotech and pharmaceutical companies , particularly those focused on next generation sequencing . I have a hybrid education in Computer Engineering and Molecular Biology , with 15 years of experience in both wet lab and compute technologies . My academic education was at Caltech , UCSD and SDSU . I am currently leading all bioinformatics and cloud infrastructure efforts at Factorial Biotechnologies . On the software infrastructure side , the goal is to build an integrated , cloud based platform for sequencing sample processing , sample tracking , data storage and management , QC , and data analysis . On the bioinformatics side , the goal is to combine existing methods with novel algorithms for sequencing data analysis . I was the 2nd hire at my previous company Encoded Therapeutics , and led all bioinformatics , data and software infrastructure efforts . I established bioinformatics data pipelines , implemented both AWS cloud and on premise compute and data storage environments , designed high throughput sequencing assays , developed a genomics database , set up interactive genomics visualization tools , and performed all data interpretation and analysis for the company . My bioinformatics infrastructure now supports over 100 employees and my analysis work has directly contributed to 300 M in investor funding . I like to work within in a team environment , and enjoy collaborating with laboratory biologists , data scientists , IT specialists , software engineers and business development teams . I also enjoy managing my own small team . I have many high profile biology publications from my time in academic research , and have deep R D knowledge in genomics , molecular biology , bioinformatics and computing .. Technologies :

Senior Cell Biologist . . I was working as a postdoc at Max Planck institute of Molecular Physiology in Dortmund in the lab of Prof. Herbert Waldmann , performing high throughput screening of small molecule libraries and the Phenotype characterization of a cell , using cell painting assay , proteomics technology , FACS and cell imaging . I have more than 6 years professional experience in protein purification and culturing different cell lines . . Technologies :

proteins;small molecules;interaction;screening

Associate Director , Computational Biology . . Specialties : Next Generation Sequencing , RNA seq , ChIP seq , ATAC seq , Epigenetics , Cancer Biology , Immunotherapy , Automation of NGS analysis and Visualization , Machine Learning , Statistics . Programming Languages : R , Shell Scripting , Python , Perl , C C , Java . OS : UNIX , Linux , Windows , MacOS . Technologies :

Associate Computational Biologist . Works closely with cell biologists , geneticists , neuroscientists and software engineers on an interdisciplinary research team investigating the genetic bases of neurological and psychiatric diseases . Responsible for processing and organizing sequencing data from experiments and interpretation of results . Develops software applications and data processing workflows , co authors papers , and works collaboratively to understand the biological stories from experiments that yield sequencing data . . Associate Computational Biologist at the Broad Institute of MIT and Harvard . 4 years of experience working with biological data and developing software around it . Passionate about using computers to make connections within and draw conclusions about the natural world . Curious thinker and enthusiastic collaborator .. Technologies :

Research Fellow . Dr. George Church 's group Harvard Medical School Wyss Institute for Biologically Inspired Engineering Concentration : Deep learning , Network integration , NGS analysis , database , Statistics , Genomics . Dr. Li Li is a research fellow in the Department of Genetics at Harvard Medical School . She was trained in Computational Biology at the University of Cologne and ETH . Her main research interests are machine learning , network studies , clinical informatics , and next generation sequencing . She conducted research on network analysis on different diseases , machine learning models for protein chemical interactions , and algorithms of SNP prediction . In Harvard , she is working on developing mathematical models to screen candidate genes for gene therapy . Dr. Li is an editor of Health and Medical Informatics , a panel committee member of NIPS , a committee member of Machine Learning in Health Care , and a reviewer of many top journals , including Bioinformatics , BMC genetics , and AMIA . She has also received many high ranked awards , such as Final prize of MIT solve , Best solution of Harvard BD2 K PIC SURE API , and First place of MIT datathon .. Technologies :

Scientist Cellular Immunologist Flow Cytometry Specialist . Supervise flow cytometry and antibody labeling labs , train and educate new users on operation of flow cytometry machines and provide technical supervision for all users assay development , panel designs , and data analyses ; collaborate with investigators to facilitate development of novel applications and to upgrade current technologies available at the company ; develop new or more complex flow cytometry based assays to study biologic and small molecule candidates ; evaluate new and emerging technologies ; influence assay selection strategies , and provide oversight in technology development and implementation . . Experience : Immunology and Vaccine Research , Industry Laboratory Management , Product Development , Technology Transfer Expertise : Multi parameter Immunofluorescence Assay , Immunophenotyping , Cell Sorting , Antibody labeling , Protein Synthesis and Purification , Analyses of Immunofluorescence Data FlowJo , Statistical and Graphic Analyses GraphPad Prism , Familiarity with GCLP Compliance , training and writing Standard Operating Procedures SOPs . Technologies :

Life Sciences Innovation Management Business Development . BUSINESS INTELLIGENCE . Assess the merit and strategic fit of biologic targeted therapy . Scientific , Medical Commercial rationale . Multidisciplinary evaluation of targeted cancer immuno modulation therapies . Provide strategic basis for R D , partnering acquisition . Objective opinion . Key opinion leader network in Immunotherapy arena . Analyze high financial risk decisions . Key publications . Molenaar M et al . Cell . 1996 Aug 9;86 3 : 391 9 . Molenaar M et al . Mech Dev . 1998 Jul;75 1 2 : 151 4 . Roose J , Molenaar M et al . Nature . 1998 Oct 8;395 6702 : 608 12 . Molenaar M et al . Int J Dev Biol . 1999;43 7 : 675 80 . Molenaar M et al . Mech Dev . 2000 Mar 1;91 1 2 : 311 5 . Molenaar M. Thesis March 2000 . A dual action of XTcf 3 in body axis formation . . WO2005100402 . Anti P selectin antibodies . WO2007000169 Non human mammalian arthritis model featuring human antibodies against citrullinated proteins . . Miranda Molenaar has over 20 years of experience in the Biotech Industry , managing intellectual property assets , providing competitive and business intelligence analyses to enable business negotiations and strategic decisions . Her solid scientific background lies predominantly in immunology , passive and active immuno therapeutics , oncology and autoimmune diseases , which finds basis in a university degree and a high impact PhD thesis in Medical Biology , followed by several key positions in research and development at Crucell and Genmab and numerous consultancy projects in close collaboration with renowned scientists in the fields of expertise . During these years Miranda served as member of strategic management , patent work group , licensing committee , drug development teams , business development teams and acted at numerous occasions at the interface of external and internal experts with management teams . She gained broad experience in the science , product business development for all kinds of innovative biotechnology based platform technologies . Miranda exploits her analytical skills and know how to enable strategic decisions from discovery to late stage development and company investments . Companies that used her expertise include tech transfer offices , small venture funded to mid sized biotech companies , Venture Capitalists , and Patent Law firms in the field of Life Sciences . Miranda is part of an international and interdisciplinary network of key opinion leaders , specialists , and champions active in this field . Specialties : Strong analytical skills . Intellectual Property strategy . Business Development Strategy . ONCOLOGY AUTOIMMUNITY INFLAMMATION . Immunotherapy . Antibody therapy development . Therapeutic vaccine development . Cell therapy development . Organoid technology . Technologies :

Manager , Bioinformatics . . . Technologies :

Lab Head Medicinal Chemistry Novel Modalities . . Medicinal chemist working on small molecule drugs and novel modalities PROTACs , bifunctional modulators , molecular glues etc . for the treatment of cancer and other diseases .. Technologies :

molecular glues;small molecules;developing

Assistant Professor . Scientific focus : DNA nanotechnology based tools and devices for applications in biophysics , molecular biology , nanomedicine , material science , and nano photonics ; development of a next generation DNA synthesis technology for oligonucleotides and de novo gene synthesis . . Our research group is developing DNA based tools for single molecule cryo electron microscopy of membrane proteins .. Technologies : CryoEM

membrane proteins;structure

. . Biophysical chemist with a doctorate in nanobiotechnology . Inter disciplinary research experience involving chemistry , material pharmaceutical sciences , biophysics , cell biology , nanomedicine and chemical neuroscience . Worked with four pioneer scientists in their respective fields : Horst Vogel Biophysical Chemistry , David R. Colman Neuroscience , R. Bruce Lennox Nanochemistry Materials Science and Patrick Couvreur Nanomedicine Biopharmaceutical Technology . Teaching skills at grad and undergrad level . Experience in supervising MSc . , and Ph.D. students . Research expertise in : liposomes supported bilayers ; organic synthesis ; bioconjugation ; confocal fluorescence microscopy spectroscopy ; cells ; drug delivery ; immunocytochemistry ; Cryo EM . Currently looking for challenging independent researcher teaching positions .. Technologies : CryoEM

structure

Cryo EM Applications Specialist . Working with negative stain and cryo electron microscopy mainly single particle analysis in the EM Facility at iNANO , Aarhus University . . . Technologies : CryoEM

structure

Assistant Scientist . Guidance and expertise for determining appropriate sample conditions for cryo EM sample grid preparation using a novel device integrating cryo EM with native mass spectrometry technology Oversight on the selection , installation , and imaging parameters for an in house resource to screen and analyze cryo EM samples prepared with the novel device Subsequent image analysis to understand effects of varied experimental conditions on protein samples deposited on EM grids after transmission through a mass spectrometer , and when applicable additional single particle analysis cisTEM Training on TEM operation , best practices , and image acquisition using SerialEM ; training guidance for sample preparation for negative stain or with a FEI TFS plunge freezing device . Curious and creative research scientist with ten years of experience working in cryo EM . Extensive work operating FEI TFS transmission electron microscopes using low dose image conditions for single particle analysis or tomography related projects . Experience with multiple grid sample freezing devices and adept at devising new freezing strategies for challenging samples . Significant experience in TEM facility operations oversight , project design implementation . I enjoy working within a team effort that fosters project development and growth but am also comfortable working independently . I am interested opportunities that seek to expand the utility and versatility of this remarkable method .. Technologies : CryoEM

proteins;structure

Senior Scientist . . Experienced Senior Scientist with a demonstrated history of working in the biotechnology and biopharma industry . Highly skilled in cell therapy development , antibody discovery , protein engineering and structural biology . . Strong research professional with a PhD focused in GPCR biology from Imperial College London . . Enjoys R , python programming and data analytics . . Technologies : NMR

antibodies;engineering;structure

Principal Scientist . . PhD in organic and peptide chemistry . Substantial experience in protein chemistry , biology , pharmacology , drug development , project management , and patent strategies . More than 12 years experience in biopharmaceutical research . My research focus has primarily been within chemical and enzymatic modification of therapeutic proteins . Design of protein drugs . Development of processes for manufacture of modified proteins , purification and analytical methods . Author co author of 11 scientific publications as well as several patent applications . I have supervised two PhD students and has acted as external examiner at University of Copenhagen at several occasions . Technologies :

biologics;enzymes;proteins;developing

Senior Principal Scientist . My team works within Pfizers Biomedicine design BMD addressing various biotherapeutic project requirements from lead discovery to optimisation . We are based in Dublin Ireland . . Specialties : Antibody optimisation . Protein display and library technologies . Hybridoma production techniques . In vitro and biosensor based assay development .. Technologies :

biologics;engineering

Bioinformatics Scientist II . . Experienced Bioinformatics Scientist with 3 years of experience in NGS analysis using python , perl and C in cancer genomics in analyzing large genomic datasets , annotating variants and designing pipelines . Over 8 years of experience with RNA and DNA Seq analysis . Single Cell Analysis o Developed custom analysis to identify multiplexed samples with Hashtags and classify the cells as Epithelial or Lymphocytic based on the UMI counts of antibodies . Generating t SNE plots based on the distance matrix for antibody counts for each cell . o Clustering and expression analysis based on mRNA and Antibody derived tags using 10x genomics pipeline and Seurat package . NGS analysis o Both DNA and RNA on high performance cluster for cancer variant detection , copy number variation and fusion transcripts . Includes UMI analysis to confirm variants . Developing synthetic datasets to confirm functionality of pipelines including synthetics fastq and bam files . Good written verbal communication skills and ability to work in a collaborative environment as well as an independent worker . . Technologies :

Scientist . . Experience in computer aided drug design strategies , including structure based drug design , Molecular Docking , Molecular simulations , Virtual Screening , Free Energy Perturbation methods , Homology modelling . Ph.D. in X ray crystallography focusing on protein protein and protein DNA complexes . Experience with biochemical and statistical analysis , knowledge of chemical and biochemical databases including PDB , ChEMBL , ZINC database . Knowledge of application systems including DOCK , GLIDE , RDKit , Schr dinger suite . Experience with GPCR purification and biology . Experience with preparation of negative stain grids for Cryo EM . Knowledge in scientific programming Python .. Technologies : Xray;CryoEM

membrane proteins;nucleic acids;proteins;interaction;structure

Regulatory Submission Manager for COVID products . Authoring and support for CMC regulatory submissions to multiple global markets for the Vaxzevria Vaccine . An academic researcher by training , I have been a process validation lead for Bioreactor based mAb and vaccine programs . A year ago , I have started to support the associated regulatory submissions to multiple global markets . Since more than eight years , I have dedicated my efforts to the late stage development and validation of upstream and downstream processes for the GMP manufacturing of biological therapeutics , applying a Quality by Design approach . For Vaxzevria , I have been leading the validation strategy and tech transfer for two CMOs in a global network of over 25 CMOs . Before , I acted as a project lead and validation lead for several NBE and Biosimilar projects , after having acted as as DSP validation expert SME . I recently started supporting all types of regulatory submissions for COVID vaccine and antibody programs . Within the field of scientific writing , I am experienced in documentation directly or indirectly addressing the health authorities . I have several years of experience as an academic postdoctoral researcher in the field of molecular infection biology . I am also a certified medical writer and science journalist .. Technologies :

Postdoctoral Researcher . In The Hanein lab we use Cryo EM single particle and tomography approaches to determine three dimensional structures of macromolecular assemblies in fully hydrated state , close to their native environment , in situ . We combine cryo focused ion beam cryo FIB for the thinning of frozen hydrated biological specimens with cryo electron tomography cryo ET analysis in unperturbed cells . In the lab I am specialised in cryo EM image processing single particle reconstruction and mainly subtomogram averaging . Nowadays , it is the bottleneck of these technologies , a very new field in continuous change with many things to be done and discovered . . I finished my bachelor s degree in Biology at the Complutense University of Madrid in 2014 . Following this , I completed my Master s degree in Microbiology gaining experience in Molecular Biology and Biochemistry while working on biodegradation of oil by higher fungi . During an internship at the Biological Research Center in Madrid , I began working in the field of Nuclear Magnetic Resonance NMR for the first time with molecular recognition and chemical glycobiology . In 2016 , I obtained a place on the Pasteur Paris University International Doctoral Program Marie Sk odowska Curie actions H2020 and joined the group of I aki Guijarro Biological NMR Technological Platform . During my PhD , I worked on the structural and characterization of Functional Amyloids from the fungal pathogen Aspergillus fumigatus . I obtained the PhD degree in December 2019 . After , I joined the The Hanein lab to work on Cryo EM single particle and tomography approaches to determine three dimensional structures of macromolecular assemblies in fully hydrated state , close to their native environment . I am specialised in cryo EM image processing single particle reconstruction and mainly subtomogram averaging which is the bottleneck of these technologies , a very new field in continuous change with many things to be done and discovered . . Technologies : CryoEM;NMR

proteins;structure

Principal Scientist . Design , architect , and built one stop shop platform integrated informatics solution for drug discovery to access and manipulate internal and external R D data and support scientific decision making Design , architect , and support global Research sample management activities for biology . Provides computational sciences expertise and support for chemistry and biology departments . Play a Technology expert and Architect role . . Specialties : Data Science , Research IS , Software development , Database development , Cheminformatics , Molecular Modeling . Technologies :

Postdoctoral Fellow . Studying the role of the Tau protein in Alzheimer 's Disease using a variety of techniques . Gaining expertise in mammalian cell culture , stem cell culture , a primary tissue culture . Cellular imaging in live and fixed cells using fluorescent microscopy on an array of instruments . . PhD. in biochemistry with advanced analytic skills , a strong publication record , and a even stronger work ethic . Skilled in protein and nucleic acid biochemistry , structural biology , bioinformatics , mammalian stem cell culture , fluorescence microscopy , and data science . Experience programming in Matlab , Python , Java , and C .. Technologies :

idps;proteins;characterization

PHD Student . Group of Christian Loew Structural Biology Unit EMBL Hamburg Cryogenic Electron Microscopy Cryo EM on integral membrane proteins X ray crystallography LCP , vapor diffusion Molecular cloning , expression , and purification of proteins using mammalian cell culture HEK cells Reconstitution of membrane proteins in membrane mimetics nanodiscs , saposin , amphipoles , detergents . . Technologies : Xray;CryoEM

membrane proteins;structure

Postdoctoral Scientist . . CV : Feb 2022 to date Postdoc , EMBL Heidelberg Nov 2021 PhD in Biochemistry Summa cum laude , Max Planck Institute of Biophysics department of Structural Biology and Goethe Universitaet Frankfurt am Main , Germany . Jul 2015 Master s degree in Cellular and Molecular Biology 110 110 cum laude , University of Cagliari Italy . Jul Nov 2014 visiting scientist , International Institute of Molecular and Cell Biology , department of Structural Biology Warsaw , Poland . Main tasks : purification , characterization and crystallisation of plant and microbial membrane proteins . Nov 2013 Bachelor s degree in Biology 110 110 cum laude , University of Cagliari Italy Jul Sept 2013 visiting scientist , Harvard Medical School Boston , USA , Department of cancer biology . Main tasks : Assessment of the tumour suppressive effect of miRNA libraries for the treatment of human osteosarcoma by lipo and lentiviral transfection . Wet lab skills : Culture of bacterial , yeast , and human cancer cell lines ; Cell viability assays ; Heterologous protein expression in bacteria and human cells heat shock , lipotransfection ; Protein purification and analysis : detergent solubilization , chromatography FPLC , electrophoresis BN and SDS PAGE , in gel activity assays , immunoblotting , immunopurification , acetonic and PEG precipitation ; DNA isolation , quantification , PCR ; Organelle isolation blending , cell disruption , sonication and purification by differential centrifugation and density gradient sucrose , percoll , optiprep ; Pigment extraction and quantification via UV Vis spectrophotometry ; bright field phase contrast microscopy analysis . Advanced technical skills : biological specimen preparation for transmission and scanning electron microscopy negative staining and vitrification ; autonomous operation of cryo Focused Ion Beam Scanning Electron Microscopes e.g. FEI Aquilos ; autonomous operation of 300 kV electron cryo microscopes e.g. FEI Titan Krios and data collection for single particle analysis and tomography ; tomographic data reconstruction and high resolution 3D structure determination . Computer skills : proficient in Macintosh , Windows and Linux based operative systems ; proficient in Linux bash and MATLAB scripting ; basic knowledge of Pyton scripting ; proficient with the Microsoft office package Word , Excel , Powerpoint etc . , LaTeX , and citation tools e.g. Endnote , Mendeley ; intermediate knowledge of 3D graphic analysis and animation softwares e.g. Chimera , Cinema4D . Languages : Italian mother tongue English C level , advanced German A level , basic . Technologies :

proteins;expression;structure

Research And Development Scientist . . I am interested in variational approximate inference in probabilistic models and probabilistic modelling in general . Please check the link above for what I like to work on . Not a great hashtag warrior , in the best case , I understand 20 of what people post here .. Technologies :

Associate Director , Bioinformatics , Oncology . . Computer Scientist , Computational Biologist , and Bioinformatician , with over 10 years of experience in research development and design implementation of algorithms and computational methods towards biological data analysis for the purpose of genetic biomarker identification and discovery . Proven ability and desire to develop computational strategies and efficient software for analysis of large scale , high throughput data , followed by effective communication of findings via scientific publications and conference presentations . Next generation sequencing NGS analysis , single nucleotide polymorphism SNP array analysis . Programming proficiency in Java , C , and C , with experience in Cloud Computing . Familiarity with AWK , Shell , Python , and SQL . Experience with resources : RefSeq , HapMap , COSMIC , 1000 Genomes , dbSNP , and TCGA . Technologies :

Senior Research Staff Scientist . I conduct research in the Information and Systems Sciences Laboratory where I am a member of the Center for Human Machine Collaboration and the Center for Autonomy Computing : Principal investigator on a research program related to predicting rotator cuff injury in workers . Task lead on a research program related to analysis of capabilities and development of metrics for neuromorphic computing platforms . Program manager on a research program related to AI techniques for vehicle engine control . Principal investigator on a research program related to developing statistical and machine learning based prognostic tools for worker injury risk assessment . Principal investigator on a DHS program , Continuous Behavior based Authentication for Mobile Devices . Task lead investigating state space observability on dynamic networks for a Government sponsor . Researcher on a program with a corporate sponsor related to autonomous driving . Program manager on a collaborative research program investigating applications using brain inspired neuromorphic hardware . Principal investigator on research programs with related to airline cabin usability and factory floor process simulations . Principal investigator on a research program with a corporate sponsor and the FAA directed at establishing new injury criteria for future seating configurations . Principal investigator on shared research programs related to goal directed neuromuscular control of movement for enhanced human machine interfaces . Developed robotic calibration solutions involving robotic wire insertion . HRL program manager on KRNS MEANING , part of the IARPA KRNS Knowledge Representation of Neural Systems program . Investigated biologically inspired motor control using networks of artificial spiking neurons for the DARPA SyNAPSE program . Contributed to the DARPA Phoenix program related to telepresence and control of space based robotic systems for harvesting satellites in geosynchronous orbit . . I currently work at HRL Laboratories formerly Hughes Research Laboratories in the Information and Systems Sciences Lab . I 've previously worked at Sandia National Laboratories and General Dynamics Electric Boat in a variety of roles from project engineering to research and development . Specialties : Biomechanics , robotics , control theory , and autonomous systems .. Technologies :

Postdoctoral Researcher . Finding new ways to destabilize MYCN , which is a main genetic abnormality in Neuroblastoma . MYCN protien which is a main oncogenic modality in neuroblastoma and several other cancers in undruggable . I identified its partners which modify MYCN posttranslationally . My idea is to target MYCN modifications thorugh inhibiting its arginine methylation and thereby repressing its transcriptional activity . In collaboration with GSK I am currently evaluating preclinical effects of argininge methytransferase inhibitors . I am also involved in developing new PROTACs in collaboration with Tocris Biosciences , UK . During my period in Bristol , as a Co PI I procured two grants to study drug resistance in neuroblastoma and evaluating PRMT5 inhibitors in Rhabdomyosarcoma . Whilst at the University of Bristol , I am involved in giving lectures to third year undergraduate students Developmental Genetics Embryonal Cancers . I am also responsible for taking tutorials for first and second year undergraduate students 4 8 hours per year . I have taken tutorials on the Normal and Tumour cells , Cellular and Molecular Pathology , and Disease and Defence units . I assess the presentation skills of the students and give written feedback . I am regularly involved in supervision of research projects of undergraduate , postgraduate taught and PhD students . My AFHEA training helped in designing innovative methods of teaching . For example , I implemented and engaged students with hands on experience right from the start of the project . Also I effectively engage students in their projects by giving small problems and encourage to come up with solutions on their own . . Seeking a academic position particularly in cancer drug discovery where there is a scope of learning and contributing my expertise towards the progress of the projects . My research interests include : identification and validation of novel anticancer targets and mode of action of small molecule inhibitors that target aberrant cancer signalling pathways , harnessing evidence based medicine to treat sub set of tumours that are highly sensitive to specific anticancer drugs and identification of novel biomarkers which could help predict sensitivity resistance to targeted drugs . Motivated to translate basic research into the clinic for better cancer treatment Specialties : Animal tissue culture , cell based assays ELISA , MTT , alamar blue , luciferase promoter activity , galactosidase senescence and Caspase 3 7 assays etc . , clonogenic assays , drug combination studies , SDS PAGE Western blotting , Flow Cytometry Cell cycle , mitotic index pH3 ser10 , TUNEL assay , PgP , MRP , and Cyclin B1 expression , BrdU , BrU staining , CHIP , gene cloning , qRT PCR , DNA microarrays Affymetrix based , RNA interference siRNA , shRNA , immunoprecipitation , protein degradation assays , immunofluorescence , mass spectrometry basics , basic knowledge of data analysis of OMICS data , routine bioinformatics databases tools and statistical analysis . Technologies :

small molecules;interaction

Professor of Computational and Systems Biology . . . Technologies :

PHD Fellow . Nicholas M.I. Taylor 's group Determining the structure of Photorhabdus virulence cassettes , extracellular contractile injection systems , with their cargo variability and limits , by using advanced molecular biology techniques and high resolution cryo electron microscopy . Project funded by LaCaixa Foundation Postgraduate Fellowship Abroad 2021 . I am a motivated , curious and hard working junior researcher in Life Sciences . I have fulfilling experience in experimental design and laboratory tasks , being autonomous in overall planning of experiments and critical in data interpretation . I have strong organizational skills that enable me to efficiently coordinate multiple projects and meet deadlines under pressure , without compromising quality of work or safety . I consider myself an energetic person who loves science , research , swimming , climbing , cooking , travelling , dancing , and spending time with my family . A combination of all these aspects , in properly healthy doses , makes me feel the happiest .. Technologies : CryoEM

proteins;structure

Scientist in Biophysical Characterization . . I am an expert in the biophysical characterisation of proteins . I have experience with co development and marketing of state of the art biophysical instrumentation , user training and support , science communication , as well as collaboration with academia and industry . Colleagues describe me as supportive , patient , structured , reliable and enthusiastic . I am passionate about supporting researchers in the life science sector so they can obtain reliable and trustworthy data .. Technologies :

proteins;characterization

Chemistry Group Leader . . Medicinal chemist with 40 publications patents . Major contributor to the development of the FDA approved ADC Zynlonta . Experienced in the field of antibody drug conjugates payload design and synthesis . Collaborative team player , mentor and line manager . Lead chemist on AstraZeneca s Tesirine SG3249 discovery and preclinical development program . External collaborations chemistry support and driver . Synthetic campaign outsourcing from bulk intermediates on Kg scale , to highly potent API purification and isolation . Health and safety group representative . Interests in modern oncology chemistry technologies and fields such as PROTACs , DDR , and IO . Speakers at several forums , including World ADC , and Royal Society of Chemistry conferences . Aim to contribute to and drive oncology drug discovery projects .. Technologies :

antibodies;molecular glues;small molecules;developing

Associate Principal Scientist . . . Technologies : SPR;NMR;FP

Senior Director , Research Informatics IT . SENIOR DIRECTOR , RESEARCH INFORMATICS IT April 2018 present Principal liaison between drug development teams and research informatics and IT efforts . Ensuring the alignment of global research stakeholders ' expectations with possibilities within research informatics and within the field of computer science as a whole Providing leadership and direction to research informatics and IT teams , managing and collaborating with a staff of scientists , software developers , IT professionals , engineers , and contractors . DIRECTOR , BIOINFORMATICS January 2005 April 2018 Developed integration strategies for the close alignment and expansion of research informatics and IT infrastructures across Kyorin Pharmaceutical s global research sites . Designed and coordinated the implementation , acquisition , and integration of research informatics and IT solutions in support of ActivX s technology platforms , corporate IT infrastructure , and Kyorin s global drug discovery efforts . Developed , implemented , and validated algorithms for the visual and quantitative analysis of highly complex proteomics data . Provided computational biology solutions utilizing various sequence and structural bioinformatics techniques including virtual screening and molecular docking approaches to aid in the design and improvement of drug candidate molecules and proprietary probes . Conducted next generation sequencing NGS and statistical data analysis PROJECT LEADER , BIOINFORMATICS July 2002 January 2005 Designed and developed Laboratory Information Management System LIMS components in multiple programming languages based on multi tier enterprise systems architecture design models . Designed and implemented the full integration of robotic liquid handlers , automation systems , and scientific instruments into a unified data pipeline infrastructure . . Technology leader with a deep understanding of research informatics data and a love for science and tool building . Passionate about enabling scientists to accelerate drug discovery and experienced implementing , supporting , and applying cutting edge software and hardware solutions to solve new data challenges . Conversant in multiple scientific and technological domains , including genomics , biology , chemistry , data science , information technology , software development , and data management . Proven record of leading projects to increase operational efficiency and improve collaboration among scientific and biotechnology teams . Adaptable strategic thinker able to define objectives clearly ; highly motivated to set and achieve challenging goals .. Technologies :

Scientist . Responsible for developing downstream recovery and purification for recombinant peptide based antigens to be tested in pre clinical and clinical trials . I have many hours hands on laboratory experience with everything except for fermentation , working on candidates for malaria , pneumonia and turbuculosis in collaboration with multiple international partners . Development of downstream processes for recovery and purification 1 . Recovery of peptides Depth filtration Tangential Flow Filtration removing cell debris , endotoxin etc . 2 . Purification of peptides KTA Ion exchange , affinity and size exclusion chromatography , Tangential Flow Filtration concentration and buffer exchange Supporting upstream fermentation team 1 . E. Coli L. Lactis fermentation 2 . Knowledge sharing and scientific discussions Upscaling of processes and writing protocols In process analysis 1 . Gel electrophoresis techniques SDS PAGE , Western Blot etc . 2 . High performance liquid chromatography e.g. size exclusion 3 . Dynamic light scattering 4 . Absorbance quantification Manufacturing batches for pre clinical and clinical trials Risk Assessments Improving quality systems in compliance with GMP . I work at Statens Serum Institut as bioprocessing scientist in vaccine development . We develop and set up vaccine pilot batch production under GMP conditions for clinical trials and non GMP for preclinical trials . I currently develop downstream processes for purification and filtration of antigens biologics . This includes choosing and setting up chromatography steps , tangential flow filtration , in process controls , stability studies of the antigen , risk assessment of the whole process to e.g. avoid microbiologic , and finally to upscale the process when it 's time to move forward to creating a GMP batch for clinical trials . Points of expertise : Process development Purification of protein strategies to remove impurities e.g. HCP , enzymes , DNA , endotoxin Fermentation E. Coli L. Lactis Stability studies e.g. intermediates with enzymes as factor , or drug substance in formulation buffer Gel electrophoresis e.g. SDS PAGE and Western Blot HPLC e.g. size exclusion GMP Quality systems Risk assesment Tech transfer Upscaling Previously I have worked with formulation and analysis of pharmaceuticals applying e.g. HPLC , DSC and Raman Spectroscopy . The latter I 've applied during a research stay at the University of Otago , New Zealand , where I developed a method for analysis of amorphous drugs and formulations . Additionally , I am a skilled data programmer using MATLAB and Python for both automation of data processing and multivariate analysis .. Technologies : DSC

peptides;characterization;quality;stability

Sir Henry Wellcome Fellow . At Manchester , my research focus centres on evolution during interbacterial competition . Using modelling and lab based evolution , I am studying how bacteria evolve during attacks by toxin armed competitors . My aim is to characterise the emergence of new resistance mechanisms , and elucidate their impact on competitive microbial communities . . . Technologies :

Postdoctoral Fellow . Cryo Electron Microscopy , Structural Biology , Chemical Biology . . Technologies : CryoEM

structure

Senior Scientist . Danish medium sized pharmaceutical company with strong focus on dermatology and skin disorders such as atopic dermatitis , psoriasis , eczema and rare diseases . DMPK representative in several cross functional project core teams and with close collaboration with especially chemistry design teams , but also toxicology and pharmacology . Daily management of DMPK in vitro and phys chem team 4 6 persons , scientists and technincians with focus on stability studies including metabolite identification microsomes , hepatocytes , whole blood and human keratinocytes , permeability Caco 2 and plasma protein binding , as well as logD and solubility measurements . Responsible for outsourcing of in vitro DDI studies and data interpretation . Involved in general Discovery DMPK Strategy work and responsible for strategies with focus on Beyond Rule of 5 molecules and small peptides . . Skilled and curious DMPK scientist and leader with 15 years experience from Drug Discovery in small biotech to Big pharma . Responsible for in vitro DMPK assays , outsourcing , and day to day management of in vitro and phys chem teams 4 6 persons , as well as hands on experience . Experienced member of cross functional project core teams , and DMPK representative in Med Chem teams in several successful Discovery projects . Result oriented with strong focus on collaboration and problem solving , and with broad experience from DMPK strategy work with focus on small molecules as well as beyond Ro5 modalities such as PROTACs and small peptides . 10 publications in peer review journals or in press . Social foodie and wine lover with a passion of meeting new people . Married with two beautiful kids . . Technologies :

Human Genetics Researcher . I use computational approaches PrediXcan and its extensions on large behavioral datasets in order to pinpoint specific genes within the 16p11.2 and 22q11.2 copy number variants that are contributing to behavioral traits . The first article from this study Integration of genetic , transcriptomic , and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes is available on BioRxiv . I have also been involved in outreach through the Science and Education Partnership program , as well as chaired Admissions and Recruitment for graduate students to our department . . I conduct research in human psychiatric genetics in the Lauren Weiss Lab at UC San Francisco . I enjoy applying GWAS and post GWAS approaches to big cohort datasets in order to answer questions about human behavior . Previously , have tried my hand at computer graphics based simulations and RNA seq analysis including single cell . I will be on the job market towards mid 2021 and am looking primarily at non academic careers ; however I am open to discussing opportunities in academia . I am a hard working independent learner who is eager to take on challenges . I enjoy collaborating with others as part of a team , and I find collaboration makes difficult tasks run more smoothly . In addition , I am passionate about teaching , training , and science education for the general public . . Technologies :

POSTDOCTORAL RESEARCH FELLOW . . My research includes single particle cryo EM analysis for atomic resolution structure determination of biological molecules , as well as cryo ET of cells and organelles towards subnanometer resolution . . Technologies : CryoEM

proteins;structure

Scientist . . . Technologies :

Scientist and Head of PhysChem . . Scientist Lab Head PhysChem with expertise in Solubility , Lipophilicity and Stability matters for several types of Small Molecules , PROTACs and small peptides .. Technologies :

peptides;stability

Laboratory Technician . Lab Technician Fromme Lab Bioenergy Studying the structural basis of the PSI LHCI Cyt b6f supercomplex utilizing SPA Cryo EM Develop new processing and visualization scripts for X ray Emission Spectroscopy data Analyze Cryo EM data using Relion and VMD MDFF to determine 3D protein structure . I am a Masters student at Arizona State University pursuing a degree in Biomedical Informatics with a certificate in computational life sciences . I work at the Center for Applied Structural Discovery where we focus on determining the structure , molecular dynamics , and the overall system of many crucial proteins responsible for Photosynthesis PSII , PSI , cyt b6f , PC , ATP Synthase , etc . My responsibilities range from protein isolation purification , Cryo EM , and X ray crystallography depending on the protein . I also have experience analyzing EM data , serial crystallography data and X ray emission spectroscopy data collected from various labs around the world . I have experience collecting serial femtosecond crystallography biophysics data from various international accelerator laboratories including the EuXFEL in Germany and SLAC in Stanford , CA . I have also joined a team that is developing a new data processing pipeline for X Ray Emissions Spectroscopy data in hopes to better observe the oxidation state changes in the oxygen evolving complex inside Photosystem II during photoexcitation . On top of my job , I also volunteer at the Center for Personalized Diagnostics where I am developing new data fusion deep learning software to assist in diagnosing developmental dyslexia using multi omics datasets . I am using machine learning in order to better explore data containing genomic , metabolomic , phenotypic , and possibly micro biome data for dyslexic and normal cases . The field of multimodal data fusion and deep learning is still fairly new in regards to systems biology so we are excited to push the boundary and see what comes from it .. Technologies : Xray;CryoEM

proteins;structure

Americas service support . Cryo Electron Microscopes . . Technologies : CryoEM

Postdoctoral Associate . . A highly motivated postdoctoral research associate with extensive experience in cryo electron microscopy , including hands on experience in sample grid preparation with Vitrobot and CP3 , independently operating the microscope Titan Krios , Glacios and Talos F200 . Expertise in structure determination software including Relion , cryosparc , EMAN2 and model building software including Chimera , Coot , Rosetta and Phenix .. Technologies : CryoEM

proteins;structure

Postdoctoral Fellow . Identified the mechanistic link between disrupted folate metabolism and adenine auxotrophy by utilizing genome wide genetic screens and large scale drug screens 90,000 compounds Developed biochemical and cell based assays of folate and purine metabolic pathways Designed experimental pipelines for high throughput phenotypic screening for modulators of subcellular MTHFD1 function Designed and optimized in vitro assays for novel PROTACs in collaboration with an in house chemist . Experienced Postdoctoral Researcher with a demonstrated history of working in the research industry . Skilled in Molecular Biology , High Throughput Drug Screening , Biotechnology , Cell Culture , and Microscopy . Strong research professional with a PhD in Bioengineering from UC Berkeley UCSF . . Technologies :

molecular glues;proteins;small molecules;interaction;screening

Scientist . . . Technologies :

Professor in Decision Sciences . . Experienced Academic with a demonstrated history of interdisciplinary research , knowledge transfer , teaching and leadership in higher education . Skilled in Optimisation , Data Science Machine Learning , Operations Research and Applications Contexts including Logistics , Marketing , Healthcare and Computational Biology . Experience of research in a variety of international contexts including Germany , Australia , Belgium , US and UK .. Technologies :

Clinical Research Data Manager . . . Technologies :

Senior Research Associate . Molekyl r biologi . I work primarily with amylases . Protein engineering , Site directed mutagenesis , Bacillus expression . Cloning in Bacillus , Screening of libraries in Bacillus , and amylase activity and stability assay . Technologies :

proteins;engineering;stability

Senior Scientist . DMPK Developing computational and mathematical PKPD models to determine FIH dose projections and guiding early feasibility analysis . Developing QSAR models for predicting ADMET endpoints using ML and DL techniques . Developing shiny applications for various projects for non experts . In depth knowledge of Mechanistic PK PD model development for large and small molecules , Machine learning techniques , programming in Matlab , R , Python . Experienced in 1 Building optimization algorithms 2 Building mechanistic population PKPD models using Nonmem , Monolix , Matlab , R 3 Analyzing Omics data . 4 Building basic PBPK model using simcyp , PKSim 5 Building shiny apps to communicate PKPD model results 6 Developing QSAR models for predicting ADMET endpoints using ML and DL techniques .. Technologies :

Principal Investigator . Advisor : Eva Nogales , PhD . Passionate research scientist uncovering mechanisms of molecular and cellular biology through protein RNA biochemistry and cutting edge structural methods including cryo EM cryo ET . Currently a Principal Investigator at a Stealth Biotech in SF NIH NIGMS K99 R00 awardee Helen Hay Postdoctoral Fellow : UC Berkeley Eva Nogales Lab and MIT Thomas Schwartz Lab PhD : Johns Hopkins University , Biochemistry , Cellular and Molecular Biology Rachel Green Lab .. Technologies : CryoEM

nucleic acids;proteins;structure

Research Scientist . . Highly ambitious , hard working and solution oriented scientist , possessing a high personal drive to always learn new things and to get better in my line of work . My experience has taught me that I am very motivated when challenged in a environment with big responsibilities and strong commitment During my professional carrier I have had several roles in the field of New Product Development and Introduction NPD NPI , including Quality Assurance , Research Scientist and Project Coordinator . I have through these roles worked in close collaboration with highly skilled colleagues across all departments and functions of the company . I have during these collaborations attained high knowledge and experience with Design Control , Risk Management and New Product Development . I am very solution oriented , and have quickly gained strong communication skills coupled with a great ability to coordinate and execute assignments with different stakeholders , while setting direction and driving high quality work . My personal drive and motivation is at its highest when working on innovative or ground breaking project , where I will be challenged to create valuable and sustainable solutions . I always approach all assignments with curiosity , professionalism and humor , as I believe that an informal yet professional work space is the ideal environment for innovation and motivation . Hard Skills : Process and Method Validation Research and Development Antibody Development and Characterization Proteomics and Probes IHC and ISH Statistical writing Quality Assurance Planning Time Management Process Optimization Risk Management Design Change Control Biotechnology , Biochemistry , Pathology Immunology cGxP Soft Skills : Pragmatic Mindset Good Communication Interpersonal Skills Negotiation Conflict Management Structured Logical Committed Persistent Reliable Responsible Solution Oriented Attention to Detail Ambitious Self motivated IT Skills Microsoft Office : Word , Excel , PowerPoint and Sharepoint ERP : SAP and Oracle . Technologies :

antibodies;characterization

Technician . Cryo electron microscopy . Biologist skilled in Cryo and Classic Electron Microscopy , sample preparation , data analysis , science , protein purification and expression . PhD focused in structural biology electron microscopy . . Technologies : CryoEM

proteins;expression;structure