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Research Scientist Associate IV . I help run the Sauer Cryo EM facility at UT Austin alongside Alex Brilot . I assist in training , help make sure the facility runs smoothly , help troubleshoot issues with the Electron Microscopes , and perform research for outside users . . My fascination with detail brought me into the field of biochemistry and continues to drive me through my PhD. I loved the level of detail of chemistry but had a greater appreciation for the stories behind biology . In my first biochemistry class at the University of Michigan , I was absolutely fascinated being able to visualize the atomic structure of chymotrypsin and the clues the structure gave about how it functions . Fast forward several years , and I m now working on the structural biology and biochemistry of type I CRISPR complexes using Cryo electron microscopy . Being able to see real images of proteins and protein complexes has cultivated my curiosity and attention to detail that I felt in my first biochemistry class . I 've also had the wonderful opportunity to present this research at various conferences and retreats , such as CRISPR 2019 in Qu bec City . I ve begun to expand my fascination for detail into other areas that I m passionate about , including science communication and mental health . My first volunteering experience was with Present Your PhD PYP , a group at UT Austin run by graduate students that does science communication and outreach for K 12 students . In a given PYP event , a graduate student presents their PhD research in a way that s digestible for younger students while encouraging engagement and curiosity from them . I ve also been a part of the Innovative Genomics Institute s Ask a Scientist program , where anyone can ask any scientific question and receive a 1 to 1 response from a scientist , either by email or zoom . This past fall , I also began to volunteer with the UT Counseling and Mental Health Center as both a student advisor to discuss mental health resource availability to graduate and undergraduate students and a student peer support group leader . My plan going forward is to graduate with my PhD in May 2022 and transition into a career of pharmaceutical research using cryo EM . I hope to utilize my skills both as a scientist and as a communicator to succeed in the biotech industry and facilitate therapeutic research through a structure based design approach . I am looking forward to learning the strategies of industry research and collaborating with other scientists who may be experts in other biochemical methods in a shared goal of developing therapeutics .. Technologies : CryoEM

proteins;structure

Senior Scientist . . Design , synthesis and purification of complex target molecules drug like small molecules , splice modifier small molecules , peptides and PROTAC s . Med Chem lead for several early projects in the neurodevelopmental and movement disorder field . Strong problem solving ability in organic chemistry demonstrated in several CNS and oncology projects . Able to use modeling techniques independently or together with CADD expert to rationalize findings and to design new compounds . Developing of SAR for a given class to reach a decision point considering medicinal chemistry parameters for optimization . Leading a team of external co workers at a CRO . Instructor of students and Lehrmeister of apprentices . Preparation of patents and co author of publications . Effective communicator of results in oral and written form in cross functional project teams . Responsible for full compliance to all Safety Health Environment SHE regulations .. Technologies :

molecular glues;peptides;small molecules;interaction

CIO VP of Research Infrastructure . Integrating and advancing the infrastructure of Gladstone , including all IT functions , physical facilities , and core recharge units . . A strategic builder and leader of high performing teams in high tech and biotechnology . A proven creator and promoter of innovative and people oriented company culture .. Technologies :

Principal Scientist . We craft computational solutions to facilitate the discovery and design of molecular therapeutics . We harness the power of Deep Learning , Structural Biology and Bioinformatics to help shape the therapeutics of tomorrow . . 8 years of research experience in Bioinformatics , computational and structural Biology . 15 publications in peer reviewed international journals Extensive hands on experience with protein structure modeling , protein docking and computational genomics . Broad knowledge and experience in areas related to macromolecular crystallography Well experimented with Machine Learning Methods and Deep Learning approaches . Profound knowledge in coding , web development , and new technologies . New technologies enthusiast , experience in web and smartphones development Self motivated , innovative scientist able to thrive in a multidisciplinary environment . Exceptional team player , very comfortable in a fast pacing collaborative environment . Experience in writing and reviewing research papers , proposals . Creative problem solving and supervising experience . Public speaking skills and experience in delivering an effective presentation . Programming and Computer Skills Proficient in many modern coding languages Python , Java , PhP , C , Objective C , Jquery Deep Learning Frameworks Tensorflow and Pytorch Database design and management RDBMS MySQL , Oracle , PostGreSQL NoSQL MongoDB Web 2.0 design HTML5 and CSS3 , PHP frameworks Kohana , CodeIgniter and smartphone applications iOS . Technologies :

Adjunct Professor . . Experienced Research Scientist with a demonstrated history of working in the biomedical academia . Skilled primarily in Structure based Drug Discovery and Patch Clamp , but also in Recombinant DNA , Computer Repair , Biotechnology , Cell Culture , and Life Sciences . Strong research professional with a Doctor of Philosophy PhD focused in Biomedical Sciences from Rutgers University . . Technologies :

small molecules

Associate VP , Structural Biology . Discovering new therapeutics using atomic resolution insight . . So far my professional journey has taken me from basic to applied membrane protein structural biology research via drug discovery and product development to creating new business ventures . I have lead gene to X ray structure scientific research projects , managed a portfolio of research and product development projects and devised real life information systems and laboratory automation systems that are delivering business value to this very day . I hold five U.S. patents , have published more than 30 articles in peer reviewed journals , and have obtained several grants funded by the National Institutes of Health NIH for membrane protein crystallization and imaging technology development . I have enjoyed working with scientists at Johnson Johnson , Bayer Schering Pharma , Gilead , Biogen Idec , Hoffmann La Roche , Bristol Meyers Squibb , Vertex Pharmaceuticals , Merck Co. , Glaxo Smith Kline , Leidos , UCB , Astra Zeneca , Celgene , Heptares , Genentech and others . My hands on target expertise include membrane proteins : b2AR , beta 2 adrenergic receptor , Corticotropin releasing hormone receptor 1 CRF1 , prostaglandin E2 PGE2 receptor , glycerol channel GlpF , bacteriorhodopsin bR , sensory rhodopsin II SRII , outer membrane protein ompA , outer membrane protein ompF , light harvesting complex II LHCII , photosynthetic reaction center RC , acetylcholine receptor AChR , orexin receptor II OX2R as well as soluble proteins SHP2 Src homology region 2 SH2 containing protein tyrosine phosphatase 2 , plasma kallikrein , lactose permease LP , maltose binding protein MBP , Tyrosine protein kinase TIE 2 , tumor necrosis factor alpha TNF and various TNFRSF . I live on Bainbridge Island , WA , am married to a wonderful woman , and have one son . In my spare time , I enjoy exploring the Pacific Northwest by foot and kayak .. Technologies : Xray

membrane proteins;small molecules;structure

Research Scientist . In my current position as a staff scientist at Stanford , my primary research focus is in translational molecular virology . Here , I study viruses and the host targets they co opt with the goal of discovering unique biology that can be exploited to create new broad spectrum therapeutic strategies . Of particular interest to me is how RNA viruses , like SARS CoV 2 and influenza , use their RNA genomes to guide biological processes . Armed with this knowledge , I help design and develop novel drugs against such RNA targets with the overall aim of not only stopping the current pandemic , but also preventing the next one . Description of role : Focus in antiviral target identification , drug discovery , and the preclinical development of novel classes of antiviral and host targeted therapeutics Scientific program manager helping to oversee a 41 M NIH contract to develop an enterovirus SARS CoV 2 therapeutic through Ph1 studies . Influenza virus research program manager for the lab , with oversight over the design and execution of experiments , assay development , as well as training mentoring of junior scientists and staff Significant expertise in nucleic acid and antisense drug design , targeting , and in vivo delivery . Developing high throughput small molecule screening technologies against RNA structure targets High level collaborator actively engaged with interdisciplinary and multi institute partnerships BSL2 certified with extensive experience in all aspects of virus and nucleic acid characterization in in silico , in vitro and in vivo assays . Virus experience in : SARS CoV 2 , human coronavirus , enterovirus EV71 , EV D68 , viral hepatitis HBV , HCV , HDV , influenza virus A B , flavivirus Dengue , Zika 1 US and international inventor patent for antiviral therapeutic . Stanford Microbiology Immunology PhD passionate about helping people through better science . I have 15 years of professional experience in a diversity of science related disciplines that enables a creative and cross disciplinary approach to problem solving . These include : Extensive experience in virology and drug development , from target identification and assay development to candidate selection and leading IND enabling studies . Program management overseeing scientific strategy , managing cross disciplinary teams , external clients , and CROs Strategy and due diligence consulting for individuals and companies from an array of fields including infectious disease , medical devices , personal health care , law , immuno oncology Diverse training and academic backgrounds in biochemistry and microbiology immunology , as well as philosophy . 10 publications in peer reviewed journals 2 inventor patents Adept writer public communicator . Technologies :

nucleic acids;small molecules;developing;interaction;screening

Senior Scientist , Computational Biology . . Computational Synthetic Biology Leader Business Development : Customer relations Public Outreach Presentations to Potential Clients and Investors Systems Biology : Metabolic Pathways Flux Modeling Genomics Software Development : High Throughput Automation Data Collection and Analysis Systems Synthetic Biology Software Strain Protein Evolution : Library Design HT Data Analysis LIMS Data Driven Analysis : Scripting Annotation Pipelines Advanced Visualization Communications : Compelling Speaker Thoughtful Listener Clear , Intuitive PowerPoints Management : Departments Projects People Solid grounding in biology and bench work Data driven approach to strain and protein evolution An agile approach to rapid software prototyping and application delivery 14 years of experience applying systems biology to strain improvement 18 years of experience developing bioinformatics software 10 years of experience managing multidisciplinary teams of scientists and programmers Accomplishments : Pitched to investors and collaborators . Managed long term relationships with clients . Prepared project plans and budgets for proposals to clients Improved protein and biofuel strains as much as 5 fold , designing mutant libraries Filed 2 patent applications , numerous invention disclosures and over 30 peer reviewed public and proprietary research reports Directed and aided construction of robust user friendly bioinformatics platforms enabling strain development and evolution at four biotech firms Accolades : excellent leadership qualities a huge asset ... highly recommended quality deliverables that target real needs and have proven robust and valuable instrumental in building the informatics capabilities in the emerging fields of genomics and systems biology from the ground up hard working , committed and showed great creativity in problem solving above all , Doug is a great person to work with Specialties : synthetic biology , strain engineering , strain improvement , evolution , metabolic flux modeling , metabolic pathway analysis , systems biology , microarray analysis , project management , software development , computer programming , teaching , training , bioinformatics analysis , patent analysis , management of outsourcing projects , data mining , programming in PERL BIOPERL VB ASP Java JavaScript C SQL R BioConductor .NET . Technologies :

Associate Scientist Cell Biology . Developing bioassays in support of research program in the Chemical Senses to elucidate the cellular and molecular mechanisms of chemosensation . Conducting feasibility studies of novel heterologous expression systems . . Biologist Manager with a MS in Molecular Biology , 7 years of professional experience in the Pharmaceutical Industry and 5 years in Fragrance Flavor R D. Extensive expertise in Gene Therapy , small molecule characterization , new target identification and validation with focus on GPCRs . Record of innovative problem solving and development of new experimental tools including cell and enzyme based assays , stable cell line generation . Creative , analytical , focused , and detail oriented . Work equally productively both as an independent contributor and in collaboration with team members . Effectively manage multiple projects , set priorities and meet deadlines . Merck Award for Excellence 2011 . Specialties : Gene Therapy : Development and validation of AAV based therapies . AAV virus purification , characterization and QC . Molecular biology : molecular cloning , DNA RNA isolation and analysis , sequencing , WB , GF size exclusion chromatography , SiRNA knock down , membrane preps , protein isolation , radio labeling I 125 , P 32 , S 35 . Skillful user of plate readers , automated liquid handlers , spectrophotometers , multiplex RT PCR thermo cycler , flow cytometer . Assay development : calcium flux FLIPR , ELISA , cell proliferation , apoptosis , cytotoxicity , cAMP LANCE , cAMP HTRF , lipolysis , binding assays . Cell line development . Immunocytochemistry , immunostaining of unpermeabilized and permeabilized cells .. Technologies :

biologics;carriers;quality

Senior Postdoctoral Fellow . Allosteric regulation of large protein complexes . Technology Data integration Computational Biophysics Structural Biology Bioinformatics Expertise : Protein mechanics and system 's biology by integration of molecular dynamics , cryo electron microscopy , cryo electron tomography , protein docking , cross linking mass spectrometry Allostery protein protein , glycan protein , lipid protein interactions Data integration , Python3 High Performance Computing Objects : Bacterial secretion system , Proton channels , Tyrosine kinase receptors , peptidases , GPCRs . Technologies : CryoEM

proteins;small molecules;interaction;structure

Senior Research Software Engineer . . personal website https : www.jkanche.com GitHub https : github.com jkanche . Technologies :

SVP and Research Director . I am the Research Director for a small analyst group focused on the pharmaceutical and biotechnology industry . We issue 6 reports a year advising our pharma clients on subjects such as systems biology , toxicogenomics , clinical biomarkers , and target and compound validation . Our reports are focused on the realistic opportunities in these areas and are written for the senior executive level reader . We are also interested in working with venture capital and boutique life science investment banks to help them identify realistic opportunities in therapeutics and biotechnology . . Ph.D. in Mechanical Engineering . M.S. in Mathematics and Computer Science B.S. in Mathematics 10 years in computational biology , artificial intelligence , adaptive computing . 16 years active and reserve duty in the U.S. Air Force . Last assignment on the staff of the Air Force Test Pilot School . Interests include biotechnology , manned space exploration , artificial intelligence , amateur visible and radio astronomy , marine biology , exobiology Specialties : Technology and financial analysis , venture capital due dilligence , strategic alliances , genomics , bioinformatics . Technologies :

Food Technologist . . I have a PhD in Food Technology from Lund University . My research was about whey protein powders and how the functionality and rehydration of the powder is affected by composition , heat treatment , and protein aggregation state . The research also involved powder particle characterization using different types of microscopical techniques in order to relate particle morphology to the composition and protein denaturation .. Technologies :

Director , Lab Head of Protein Sciences . . Protein Science Membrane Protein Crystallography Structure Based Drug Design Summary I am a membrane protein scientist with over 14 years of experience in leading and managing very high functioning teams . I have a passion for drug discovery and would love to help your organization tackle tough protein chemistry problems , especially membrane proteins . I earned my Ph.D. in Molecular Biophysics and Biochemistry from the University of Texas Southwestern Medical Center , where I performed Nuclear Magnetic Resonance NMR , X ray crystallography , light scattering , and microscale biochemical experiments on components of the SNARE membrane fusion machinery . After finishing my Ph.D. , I completed a postdoctoral fellowship at Novartis where I expressed and purified several G Protein Coupled Receptors GPCRs , Ion Channels , and other membrane proteins for drug discovery . At Emerald Bio , I was a Project Leader for a variety of GPCR and other membrane protein projects . At Roche , I was the head of the Nanopore and Attachment Protein Engineering Group . We developed a novel sequencing by synthesis approach that combines the best of protein engineering with the best of software , big data , and semiconductor design . After the first iteration of that product was completed , I joined HarkerBIO as the Chief Scientific Officer , where I had broad responsibility over project management as well as driving scientific excellence . Specialties Protein Science Membrane Proteins Structure Based Drug Design Fluorescence Spectroscopy Microfluidics Nuclear Magnetic Resonance NMR X ray Crystallography Immunofluorescence Confocal Microscopy Membrane Protein Purification and Reconstitution Start up and small business consulting . Technologies : Xray;SLS DLS;NMR

membrane proteins;interaction;stability;structure

Director , Chemical and Exploratory Cell Biology . . Passionate scientist and research project leader with 7 years of experience in preclinical small molecule drug discovery Open and patient centric mindset with the goal to deliver innovative and transformative therapies for unmet medical needs Result driven and pro active with a making things happen attitude Management of a laboratory with direct reports as well as experience in matrix leadership of cross functional teams and international collaborations .. Technologies :

proteins;small molecules

Technical Area Lead . Technical Area Lead for Exploration Technology . Responsible for managing the portfolio of USRA s tasks and deliverables related to R D in Quantum Computing , High Performance Computing , Machine Learning , Data Mining , Nanoelectronics , and Environmental Analytics . . I am focused on the development and integration of scalable algorithms and computing architectures . I 've been fortunate to work with amazing technical teams and execute on development and analysis of cutting edge optimization , machine learning and simulation algorithms and high performance computing HPC architectures . My current work centers on development , use and analysis of algorithms that work well with current HPC and quantum computers or inform requirements for future generation architectures . These algorithms are often based on combinatorial optimization , probabilistic machine learning or simulation covering a wide range of applications . In my PhD and postdoctoral research I improved scalability of climate models on supercomputers . I designed and implemented nonlinear and linear solver algorithms leveraging fast matrix calculations based on approximate factorization and diagonalization of subsidiary tensor products . I also developed and applied similar methods to simulations of ground water , dislocation dynamics , and stability analysis of binary alloys .. Technologies :

Lead Clinical Trial Leader . Oncology , Hematology ; Clinical Trials , First In Human studies . Accountable for all aspects of individually assigned oncology clinical trials including leading Clinical Trial Team . . Responsible for program level activities as assigned . . In addition to leading individually assigned clinical trial , First in human studies in Oncology and Hematology , also provides line management oversight to direct reports which comprise of clinical Team Leads and Associates . Early Clinical Development in Oncology : Cancer drug development First In Human trials for heme malignancies Multiple Myeloma ; Lymphoma New protocol design for Unresectable and advanced Melanoma Adapted drug combination treatment for advanced Gastric Cancers NSCLC Phase I II trials development Project Management of Clinical Trials in Oncology : Ovarian Cancer Phase III ; Lymphoma NHL Phase II ; Mantle Cell Lymphoma Phase III ; Solid Tumors Phase I for new compounds ; Program Manager for Gastric Cancer studies Phase I and III Genetic research : Molecular analysis of differential gene expression in Tumour Reversion . Protein expression and interactions studies in biological models of cancers . Patents and publications : molecular characterization of the tumour reversion pathways . Collaborations with Hospitals for the screening of Tumour Libraries . Leading collaborative research developments with pharmaceuticals labs Lynx Therapeutics or academic labs Memorial Sloan Kettering ; University of Geneva . Study of the implication of Siah1 in protein degradation Weizmann Institute published in PNAS . Cloning genes of interest and building cDNA libraries . Set up of new high throughput methods to improve the resolution of the physical map of the human genome . Construction of cloning and expression vectors . Building an experimental flow cytometer in collaboration with the Los Alamos National Lab USA for the sizing of BACs and DNA fragments . Specialties : Human Genetics Molecular Biology of Cancer Clinical Research in Oncology , Early development of new drugs . Technologies :

Research Scientist . Initiated project to determine the dynamics in a phage DNA packaging motor by NMR Corrected a virus structural model by discovering a helical protein capsid by cryo electron microscopy . . Technologies : CryoEM;NMR

proteins;structure

Biosafety Specialist . To ensure knowledge and understanding of regulatory demands in relation to biological safety of medical devices . To plan and prepare appropriate and compliant biocompatibility documentation for Coloplast products in development projects as well as for marketed products . To support the business in relation to questions related to toxicology , chemicals and safety for people . To stay on top of legislation for biological safety and chemical compliance . To develop and maintain procedures and instructions for biological evaluation activities . . Experienced biochemist with a demonstrated history of working in the biotechnology and pharmaceutical industry . Skilled in Customer Service , Life Sciences , and Microsoft Office . Bachelor 's degree focused in Biochemistry from Vilniaus Universitetas . Master 's degree in Pharmaceutical Sciences at University of Copenhagen . Deeply interested in biopharmaceuticals , manufacturing , drug formulation , protein aggregation .. Technologies :

proteins;stability

Postdoctoral Fellow . . As part of the NIH funded Medical Scientist Training Program , I had the opportunity to train on the use of cryo EM for studying virus structure and assembly . I was drawn to the technology as it provided a unique perspective for studying large macromolecules and their complex interactions with each other . My PhD thesis focused on the use of cryo EM was in determining the structural proteins and mechanism for loading DNA into HSV 1 capsids . During my training I had the opportunity to test and characterize the digital detectors that have since revolutionized the field . My work with collaborators in Hematology and Oncology broadened my appreciation for what this technology and Structural Biology has to offer to the field of Medicine . Having seen first hand how this technology was able to directly address and answer questions that to date had evaded investigators , I was intrigued in its use for drug design and vaccine development which rely on an intimate knowledge of both structure and function of these complex macromolecules . Most of my experience in cryo EM has been with large dsDNA viruses and as my career transitioned to Pediatrics upon completion of my MD PhD training , my interest shifted to apply these skills in electron microscopy and 3D structural determination towards viruses of importance to this population . Ultimately , I feel this work has the potential to define the complex structural process behind replication , capsid assembly , and viral egress within this system . I am confident that a structural approach to understanding mechanisms of infectious disease , from assembly , to virulence and pathogenesis will provide insight into novel therapeutic development .. Technologies : CryoEM

nucleic acids;proteins;interaction;structure

Senior lab manager . . Experienced Associate Researcher with a demonstrated history of working in the hospital health care industry . Skilled in Electron and Cryo electron microscopy , Epigenetics and OMICS . Technologies : CryoEM

proteins;structure

Biophysical Development Scientist . . Scientist with significant research experience in structural biology , protein biochemistry and biophysics . My skills include protein expression , protein purification , gel electrophoresis , biophysical characterization techniques , small angle X ray scattering , light scattering , nuclear magnetic resonance , spectroscopic techniques , chromatography and analytical ultracentrifugation . I enjoy new challenges and adapt to new environments easily . Outside of science , I love experiencing new cultures , trying out new foods , dancing and painting .. Technologies : Xray;SLS DLS;AUC;NMR

proteins;characterization;expression;structure

Director , Structural Biology and Chemistry . Develop and execute strategic plans to bring Gilead 's cryo EM to industry standard , provide effective structural support to virology , oncology and inflammation research pipelines . . Highly accomplished well recognized structural biologist with a passion for drug discovery . A wide network of industry and academic connections . Structure Based Drug Research . Extensive experience in using structural biology , biophysics and modeling techniques to facilitate biologics and small molecule pharmaceutical research pipelines . Science Technology . Well known structural biologist with rich experience in modern cryo EM and crystallography . Expert knowledge of soluble and membrane protein expression and purification with bacterial , insect and mammalian systems . Leadership . Results oriented and science based team leader with strong record of mentoring and team managing experience . Communication . Successful experience in designing and executing strategies operation plans , scientific exchange and team interactions . Strong organizational , interpersonal and communication skills . Strategy Operations . Demonstrated success in leading cross functional , cross site teams and building industry academic collaborative facilities .. Technologies : CryoEM

proteins;small molecules;structure

Bioinformatician . Duties : genome annotation , short read mapping , SNP calling , differential expression , pathway analysis and gene ontology , help with software development . . For recruiters : I am interested only in actual real offers . If you have a real job offer , send me an ad salary first . Save yours , and my time . Thank you . CV on request . Bioinformatician , evolutionary biologist , a geneticist with a strong computer science background . Proficient in silico biological data analysis especially Next Generation Sequencing and microarray data . Proficient and advanced computer literacy , e.g. GNU Linux , PC hardware , clusters , bioinformatics software . R and Perl programmer .. Technologies :

Postdoctoral Fellow . Laboratory of Stephen Brohawn . Biochemist with broad experience across structural and cell biology . Work spanning dynamic protein complexes at the kinetochore and ion channels at the plasma membrane . Captivated by the molecular mechanisms at the heart of large scale cell biological processes . https : scholar.google.com citations user P1BpF6QAAAAJ hl en SKILLS Protein expression : Human , insect , yeast , and bacterial systems . Protein purification : Experience with flexible complexes and membrane proteins . Cryo EM : Sample prep and data processing . Structure modeling and analysis . Protein mass spectrometry : Complex discovery , development of cross linking methods . Electrophysiology : Whole cell and proteoliposome in vitro recording . Cell biology : Tissue culture techniques , live and fixed cell microscopy .. Technologies : CryoEM

membrane proteins;proteins;structure

Postdoctoral Researcher . Structural Membrane Biochemistry Bavarian NMR Center BNMRZ Dept . of Chemistry Institute for Advanced Study Technical University of Munich . 8 years of lab experience in the field of protein structure function relationship with a comprehensive understanding of protein folding , dynamics and aggregation . Deep expertise in protein expression and purification systems , biochemical and biophysical assays for protein characterization including soluble and membrane proteins in the form of monomers or multidomain complexes . Expert in E. coli and S. cerevisiae cultures . Problem solving and analytical mindset .. Technologies : NMR

membrane proteins;proteins;expression;structure

Principal Scientist Pharmacology Toxicology and Drug Metabolism and Pharmacokinetics DMPK at . Define , elaborate and coordinate the execution of feasibility research and lead optimization projects , within the company s strategy and inter national guidelines and regulations . As team leader I manage projects from pre clinical prove of principle , toxicity and safety studies to first in human . My responsibilities include generating new ideas for a variety of projects , developing new methodologies , initiating and coordinating the execution of pre clinical studies . Establishing and maintaining an international network : universities , contract research organizations and research institutes . As subject matter expert it is also my responsibility to advise colleagues on pre clinical issues and consultation with key opinion leaders world wide . . Experienced pharmacologist with management expertise and more than 20 years of experience in preclinical research projects in the pharmaceutical industry small molecules , biologics , antibody drug conjugates , non biological complex drugs and generics . In my current position as Senior Principal Scientist at the Department of Pharmacology , Toxicology , Drug Metabolism and Pharmacokinetics at Byondis BV , I define and coordinate the execution of innovative research projects , within the company s strategy , according to global guidelines and regulations . As team leader I manage projects from pre clinical prove of principle , toxicity and safety studies to first in human . It is my responsibility to initiate and coordinate the execution of pre clinical studies conducted by contract research organizations worldwide . . Specialties : PhD in neuro endocrinology , experienced pharmacologist , expertise in management and strong technical skills in R D research in the pharmaceutical industry , such as in vitro and in vivo pharmacology efficacy , toxicity and safety , biochemistry , molecular biology , clinical chemistry and hematology . Further , I have established a diverse scientific network with universities , profit and non profit organizations . . Technologies :

Associate Scientist . Develop and optimize methods for the purification of AAV using chromatography . Working to develop a low volume analytics panel for AAV using the latest technologies for AAV titer determination and genome sequencing . . Biochemist experienced in the expression , purification , and analysis of recombinant proteins and antibodies . Past projects include the construction and characterization of insoluble hexameric proteases and its substrates , and the purification of antibodies and antigens for various in vitro and in vivo programs . Current work includes platform development for rAAV production , and supporting in vitro and in vivo gene therapy programs .. Technologies :

antibodies;carriers;proteins;characterization;expression

Postdoctoral Researcher . . Creative , independent and forward thinking scientist with a strong background in structure activity relationships of proteins . Interested in molecular neurobiology and drug design for memory disorders . Special expertise in the following areas : Recombinant expression of kinases and phosphatases in bacterial and insect systems Protein purification , characterization , in vitro bioconjugation , and activity measurement Peptide and small molecule synthesis Protein structure determination using cryo electron microscopy Excellent collaboration and communication skills as evidenced by team publications and a U.S. patent . Technologies : CryoEM

peptides;proteins;small molecules;characterization;structure

Research Specialist Gonen lab UCLA . . My PhD project led me to investigate on the ultrastructure of nanoscopic membrane lined channels called plasmodesmata , which are embedded in the cell walls between plant cells , allowing them to communicate with each other . They establish a very special kind of communication , proper to the plant kingdom , called symplastic communication , by establishing a cytosolic and membrane continuum of the plasma membrane PM and the endoplasmic reticulum ER between the cells . The ultrastructural analysis of plasmodesmata was a formidable challenge given their nanoscopic size they can be as narrow as 20 nm in diameter , location embedded in the plant cell wall and their dynamic nature . Using electron tomography of high pressure frozen , near native plasmodesmata , I provided for the first time data on their 3D membrane architecture at an unprecedented resolution see panel aside , forcing a reconsideration of the current model W. Nicolas et al . , 2017 ; Yan et al . , 2019 . I was appointed at Caltech Pasadena , USA in January 2018 as a joint post doctoral scholar in two labs , the Meyerowitz lab , specialized in apical meristem development plant biology , and the Jensen lab , specialized in cryo electron tomography cryo ET method development . I investigated the structure of crystalline cellulose producing bacterium Gluconacetobacter hansenii and E. Coli by cryo ET to better understand the cellular determinants of the cellulose crystallization process W. J. Nicolas et al . , 2020 . Because plant tissues are notoriously thick , cryo ET requires thinning technics . Because of this limitation , I specialized in cryo Focused Ion Beam milling cryo FIB milling allowing to thin samples of a maximum thickness of 10um down to 200 nm . This allowed to investigate at high resolution the structure of the plant primary cell wall in the white onion Allium cepa . I am actively investigating cellular processes like exocytosis in the pollen tube by using cryo FIB milling on pollen tubes germinated in vitro and secondary cell wall formation in whole plant cells grown in vitro . The latter required the implementation of a novel technic called the waffle method Kelly et al . , 2020 . I am also involved in various collaborations on various projects in biology and chemistry requiring cryo FIB milling . Technologies : CryoEM

structure

Scientist . HTS and kinetics . Experienced Associate Researcher with a demonstrated history of working in the biotechnology industry . Skilled in Label free Technology SPR , ITC , BLI , Laboratory Robotics , Cheminformatics , and Biotechnology .. Technologies : ITC;BLI;SPR

interaction;screening

Principal Machine Learning Researcher . . I am passionate about applying my transferable experience in computational biology , data science , and machine learning to solve challenging problems . I am an experienced technical people leader in genomic data science and machine learning , with a proven track record of building high performance teams to invent and deliver scalable algorithms and predictive models to improve customer experience and support key business objectives across a wide assortment of domains . My experience has helped me to be successful in driving cross functional programs with over 20 scientists in human healthcare and consumer genomics while driving executive buy in . Currently , innovating ML methods for unbiased proteomics at Seer . At Ancestry , I led a team to develop scalable computational and machine learning algorithms for several products . Previously , I worked as a Research Scientist at Stanford Medical Genetics , developing a system to automate diagnoses of clinical exomes . I completed my Ph.D. at Stanford and my undergraduate degrees in EECS and Bioengineering at UC Berkeley .. Technologies :

. . Protein biochemist with core expertise in protein expression , purification , biochemical and biophysical characterisation with an emphasis on therapeutic monoclonal antibodies . Track record of acheiving project goals through effective teamwork and collaborations . Skilled in the following areas : Molecular biology methods : Complex nucleic acid amplification PCR methods , whole cell PCR , RT PCR , qPCR . Cloning , restriction digestion , ligation , ligation independent methods , construct design . DNA RNA isolation , electrophoresis , purification , quantification , and sequencing . Protein purification : Microbiology methodology and Mammalian cell culture techniques . Recombinant protein expression and secretion in E. coli strains , Baculovirus , Hybridoma and HEK293 cell systems . Purification using affinity , size exclusion , ion exchange , reversed phase , hydrophobic interaction chromatography methods . Expression , purification and preparation of monoclonal antibodies . Biochemical and biophysical analyses using ELISA techniques , SEC MALS , SPR and NMR . Structural determination by X ray crystallography and cryo EM . Working in fast paced , cross functional project teams . Supervision , mentorship , and professional development of junior scientists and laboratory assistants . Specialties : Molecular Biology , Protein Biochemistry , Protein Engineering , Strain Development , Protein Crystallization , Structural Biology , Monoclonal Antibodies , Biochemical Assay Development .. Technologies : Xray;CryoEM;SPR;NMR

antibodies;characterization;engineering;interaction;structure

Principal Scientist Cheminformatics and Combinations Lead . . A computational chemist and data scientist focused on AI , drug discovery and repurposing . Experience includes time spent in academia , pharma , tech , and at Healx a fast growing startup with a great mission to accelerate treatments for rare diseases .. Technologies :

Postdoctoral Researcher . . I am a Ruth L. Kirschstein postdoctoral fellow interested in the structural biology of GPCR signaling . I have experience in protein crystallography , cryo electron microscopy , protein purification , biochemical biophysical assays , and cell based assays . I also have experience in communicating my research and mentoring . Looking forward to the next opportunity I pursue . Technologies : Xray;CryoEM

membrane proteins;proteins;characterization;structure

Director of Bioinformatics Engineering . . Proven leader , scientist and engineer with 15 years experience in the development of bioinformatics algorithms , tools and pipelines as well as analysis of Next Generation Sequencing NGS data . Most recently , played key leadership roles in developing a platform for storage , retrieval and analysis of NGS and high dimensional immune profiling data for Human Longevity and immunoSCAPE , respectively . Currently leading and building omics genomics , transcriptomics , proteomics and metabolomics tech capabilities in AstraZeneca , Cambridge , UK . Specialties : Bioinformatics , Big Data , Cloud Computing , Parallel Computing , DNA Sequencing , Genomics , Sequence Analysis , Algorithm Development . Technologies :

Pro Vice Chancellor for Research . . I hold the Foundation Chair as Professor of Mathematical Sciences at Liverpool Hope University where I am Pro Vice Chancellor for Research the Dean of Faculty of Science . I have been the Head of the School of Mathematics , Computer Science and Engineering at Liverpool Hope since January 2008 . A mathematician by training , I possess multi disciplinary expertise in Nonlinear Mathematics , Natural Computing , Bio Mathematics and Computational Biology , Operations Research , and Control Systems Engineering . I have an extensive background and experience of working in Universities in the UK and India . I have been an expert reviewer for the Biotechnology and Biological Sciences Research Council BBSRC grants peer review committees for Bioinformatics Panel ; Engineering and Physical Sciences Research Council EPSRC for High Performance Computing Panel ; and serve on the Peer Review College of the Arts and Humanities Research Council AHRC as a scientific expert member . I have edited volumes on Intelligent Systems , and Applied Mathematics ; I am the Editor in Chief of the International Journal of Artificial Intelligence and Soft Computing IJAISC and serve on editorial boards for a number of prestigious journals such as the Journal of Universal Computer Science JUCS . I am well published with over 200 publications in prestigious publishing outlets and international journals . I was awarded a prestigious Commonwealth Fellowship for pursuing my Doctorate DPhil in Applied Non Linear Mathematics , which I earned from the University of York in 1996 . I hold BSc Hons . , MSc , and MPhil with Distinction from the MDS University of Ajmer , India . Prior to joining Liverpool Hope , I was with the Department of Mathematical Sciences , and later at the Department of Systems Engineering , at Brunel University , London . Earlier I lectured at the Tata Institute of Fundamental Research TIFR , Applied Mathematics , Bangalore , BITS Pilani and the Indian Institute of Technology IITs in India .. Technologies :

Specialist . . PROFESSIONAL FIELDS Protein design Protein engineering Next generation vaccine development Antibody engineering Ph.D. in Bioengineering with a strong structural biology computational biology background and more than 7 years of experience in the integration of computational simulation with experimental validation for solving the complex biological problems . I am have : A strong publication record in leading journals A productive independent researcher with a satisfactory level of knowledge of how to interact effectively with computational and experimental biologists Extensive technical and management experience in research groups projects . Technologies :

antibodies;biologics;proteins;engineering;structure

Principal Clinical Scientist . Product Development Oncology . Ten years of experience in clinical development including three years of experience in line management 1 full time employee and one contractor . Clinical Science Experience . Disease Therapeutic Areas : Pediatric Oncology solid tumors and hematologic maligcies . Activities : . CDP development , clinical study designs development , development of clinical documents Protocols , ICFs , study related documentation , . Generation of regulatory documentations and regulatory interactions IBs DSURs updates , briefing materials , PIP PSP authoring , health authorities interactions and responses . Organisation , preparation and presentation of KOL meetings , advisory boards , Investigator Meetings . Medical monitoring , data review , and clinical data interpretation . Preparation of scientific communications scientific manuscripts posters preparation . Market Access Experience : . Disease Therapeutic Areas : Oncology Tumor Agnostic Histology Independent therapies . European Market Access University Diploma HTA assessments and policy , pricing and reimbursement , health economics . 6 months rotation in Roche Global Market Access Strategy . Participation in the development of integrated evidence plans to fulfil Payers HTA requirements . Clinical Operations Experience . Disease Therapeutic Areas : Autoimmunity , Neuroscience , Respiratory therapeutic areas , including rare indications . Activities : Responsible for planning , management , clinical execution of early phase clinical trials . Lead of multidisciplinary Clinical Trial Teams in the design , start up , execution , and reporting of First in Human , dose escalation , PK profiling , Proof of Concept Mechanism studies . Academic background : . PharmD University of Padova , Italy . PhD in Pharmaceutical Sciences University of Basel , Switzerland . Research focus : Small molecules Drug Discovery . Core Activities : Structure Based Drug Design , Lead identification , Modeling and Simulation , CYP450 interactions , and toxicology prediction . Technologies :

Senior Scientific Software and Data Engineer at RCH Sanofi . . . Technologies :

Research Internship . Drug delivery , cleavage of proteins . Use of LC MS . Method development , running samples , preparing the tables in the computer , Data analysis . Interested in an internship as a Research Assistant in Molecular Biology , Neurobiology Innovation . Idealistic , creative , analytical and curious . When I was a child , I was extremely curious , always asking many questions and constantly asking my parents to show me documentaries . What I did n't imagine was that such small actions would be the beginning of my passion for science . Sixteen years later , I am surrounding myself with experiences and opportunities and having left for my first mobility program , Erasmus in Helsinki , working in a research group , and co directing remotely my own project I am a person very committed to the community in which I live . I have started representing students and volunteering in congresses , and It had developed in having taken part in several initiatives and projects . During this time , I have gained experience with the handling of material and the way of working in a laboratory , thanks to the great weight of the practical training of the subjects I have studied . 50 of the teaching load and 30 grades . And now I am in an Internship at the University of Helsinki in Drug Delivery . I am looking to expand my knowledge , add value , and make a difference in society from a scientific perspective . INTERESTED IN : Molecular Biology , innovation , neurobiology and ethology , drug delivery systems , synthetic biology , structural biology cryo EM , NMR spectroscopy , modelling , and virology . LAB EXPERIENCE During Internship : LC MS use for cleavage of peptides running samples , preparing the samples , preparing the tables in the program , and data analysis . During the Bachelor 's : DNA extraction , vector cloning , cell and microbiology cultures , PCR , in vitro enzymatic binding of DNA , the transformation of competent cells , sequencing data analysis , digestion with a restriction enzyme , preparation on an agarose gel for DNA electrophoresis , Neubauer chamber Hemocytometer , laminar flow cabinet , indirect immunodetection by fluorescence , tissue preparation , and microscopy , enzyme characterization , enzyme inhibition studies , chromatography , absorbance measurements , statistical treatment of data , among others . Technologies : CryoEM;NMR

carriers;formulation;structure

Mechatronics Engineer . Mechatronics engineer in the instrumentation team , I am in charge of the development , construction and test of a standalone instrument for the characterization of Cryo EM sample grids . The aim is to measure , with a few nanometer accuracy , the thickness of a frozen sample at cryogenic temperatures . . Here are the main skills I have been developing those last years : Multiphysical modeling Electromagnetism , electromechanics , mechanics , fluid mechanics , Rapid control prototyping System control MPPT algorithms Signal processing Data analysis Experimental tests . Technologies : CryoEM

Associate Director , Quantitative Systems Toxicologist , GSK Associate Fellow . . . Technologies :

Scientist Computational Biology . . . Technologies :

Bioinformatics Research Scientist . I work on the Immuno Polymorphism Database IPD developing analysis pipelines for HLA and KIR sequence data as well as publication of this data in quarterly releases . . I am a Bioinformatics Research Scientist with nearly 6 years experience working on an international immunogenetics database project . I am looking for the opportunity to take the skills and experience I have developed over this time and apply them to new challenges in an applied research setting with real world outcomes . I have a focus on analysis of large genomic datasets including data mining and NGS analysis pipelines .. Technologies :

Scientist . . Biochemist and Structural Biologist dedicated to understanding mechanisms regulating the function of membrane proteins and receptor complexes in human diseases .. Technologies :

membrane proteins;interaction;structure

Senior scientist bioinfornatics . . Strong professional and self motivated individual with more than 10 years of experience in analysis of diverse biomedical data looking for a scientist position in computational biology bioinformatics data science algorithm development fields . I have worked on the algorithm development to address biomedical problems with computer science , statistics , mathematics , and engineering for 10 years since 2009 . Algorithms in my projects include machine learning , data mining , image processing , statistical modeling , and signal processing . Besides a strong background in mathematics , statistics and computer science , I also learned biomedicine including physiology , gene , neuroscience , and molecular biology . My other advantages : a good learner , an independent problem solver , and a strong self motivation personality .. Technologies :

Research Fellow . . . Technologies :

Senior Scientist . . More than 10 years of experience in field of molecular and structural biology with extensive knowledge and proven background in design and development of strategies for effective protein expression and purification in expression systems such as bacterial , yeast , insect and mammalian cells . Creative , extensively curious scientific mind with critical , but , yet out of the box , non conventional thinking .. Technologies :

proteins;expression;structure

Scientific Researcher . . I am a life science researcher with a deep fascination with the aging process . This interest formed during my university studies in molecular biology . It stayed with me during my brief delve into cancer research and finally made me enroll in PhD studies in one of Europe 's unique institutes focused entirely on aging . I have chosen a proteomics lab for my PhD study and got involved in a project regarding tracking protein protein interactions . During the studies I was able to use state of the art mass spectrometry instruments . My project involved construction of a unique model system that gives insight into proteasome interactome in both cells and animal models . We showed as a proof of concept that proximity dependent biotinylation technique can be successfully employed for tracking proteasome interactions in both static homeostatic conditions as well as upon different chemical challenges . It could be used for cell line model systems as well as mapping interactomes throughout different animal tissues . Exceptional performance of the model led to the filing for a patent regarding the concept behind it and its usage . In the immediate future , the model will be used for studying proteasome interactome changes in animal model upon aging . I am a big proponent of informational theory of aging as a major upstream cause of aging . For me its all about losing control . It 's about mistimed expression of certain genes on one hand or loss of expression of others . This in turn leading to subsequent reactivation or loss of certain gene networks at inappropriate time . I see a living organism as an immensely complex and big orchestra playing a demanding composition . For it to work all parts of the system need to play in tune . However , with time more and more members of the orchestra start to play slightly out of tune . The process is progressive , leading to the loss of quality all the way until the original tune is unrecognisable and a system colapse . I strongly believe in proximity based labeling performance and its suitability for studying mechanisms of both aging and regeneration . For this reason , I am very excited about the new stage in my career in which I am looking for positions allowing me to employ the knowledge I acquired during my PhD studies . I am also very excited about future and promise of PROTAC technology . Interested in ideas of using the same principle behind the technique to modulate proteasome activity .. Technologies :

Director , Scientific Computing . . . Technologies :

Principal Scientist , Quantitative Pharmacology and Pharmacometrics . . Scientific reseracher with extensive model based drug discovery and development experience across multiple therapeutic indications . Currently responsible to provide modelling support for several discovery and development project in oncology non oncology pipeline across different modalities . M S Experience : PBPK , PK PD , PK TOX , TK TD , Population PK , Tumor Disease Progression , IVIVC etc . Drug Development Experience : Translational PK PD , Efficacious Exposure Projections , Schedule and Dose Selection , Combination Development etc .. Technologies :

Research Scientist Assoc . Adjunct Professor . . . Technologies :

Senior research associate . Developing and generating data in a R D laboratory , setting up laboratory experiments involving catalysing enzymes . For screening purposes automation , using various liquid handlers , is an important tool . Biophysical methods for analyzing protein stability : NanoDSF , DLS , DSC , ITC . Experienced Senior Research Associate with a demonstrated history of working in the biotechnology industry . Skilled in Protein Chemistry , Biophysics , SDS PAGE , Molecular Biology , Assay Development and Biotechnology . Strong research professional graduated from herlev statsskole . . Technologies : ITC;SLS DLS;DSC;DSF

enzymes;proteins;characterization;screening;stability

Specialist . . Highly structured and self motivated scientist with broad a knowledgebase in chemistry , biochemistry molecular biology . 5 years of research experience in basic science incl . international stay . Experience from pharmaceutical industry within cGMP of small molecules and biologics Strong background in development , validation and implementation of analytical methods for small molecules and biologics . A proven team player able to work independently . First class problem solving skills . Experienced in design , statistical analysis and interpretation of experiments . Solid IT knowledge . Experience in : Analytical methods for small molecules and biologics , Analytical chemistry small molecules , Statistics , Regulatory requirements for pharmaceuticals , Protein chemistry and stability , Enzyme assays and kinetics , Structure activity relationships , Purification and Characterization of membrane proteins , Assay development , Analytical biochemistry of lipids , Detergents and Membrane proteins , Homologous and Heterologous expression systems , Strain generation , Yeast genetics , Cloning and DNA preparation .. Technologies :

biologics;membrane proteins;small molecules;developing;stability;structure

Principal Scientist . . A results driven software engineer with expertise in multi tiered application architecture and development . Able to quickly grasp scientific and technical challenges and conceptualize innovative solutions . Adaptive to new languages and technologies . Expert in C , architecture , creative thinking and problem solving . Specialties : Desktop , web , and mobile applications : C , WPF , objective C , VB.NET , ASP.NET Web standards : CSS , HTML , XML , RDF , JSON , SOAP Agile development with Scrum Database design and development : Oracle , SQL Server , MySQL Performance analysis and tuning of application and database systems Analytical chemistry , process development , and pharmaceutical manufacturing Application of design of experiments to drug development . Technologies :

Senior Machine Learning Researcher . . . Technologies :

Scientific Researcher . Probing the structure and dynamics of enzymes involved in anaerobic metabolism and carbon fixation . Understanding the enzymatic machinery used by anaerobic microbes could inspire potential applications in CO sequestration and biofuels production , leading us to tackle the current climate change crisis . Use of Cryo electron microscopy to decipher the structure of enzymes under anoxic conditions . Planning , management , and execution of the research project along with the teams at the Goethe University and SYNMIKRO research center . . . Technologies : CryoEM

enzymes;structure

Bioinformatics Scientist . . . Technologies :

Senior Protein Scientist Hays consultant . . I am enthusiastic , ambitious , and passionate to explore the field of protein science in a dynamic and successful pharmaceutical company working alongside highly skilled scientists . As a Postdoc , I bring significant knowledge in molecular biology , protein engineering , and biophysical characterisation of proteins . I have extensive experience with expression and purification of recombinant proteins , including membrane proteins . My passion for research , work experience , and communication skills have enabled me to be efficient and effective , both individually as well as in a team . Molecular biology Polymerase chain reaction , cloning and site directed mutagenesis DNA purification and agarose gel electrophoresis Protein expression and purification Protein expression in pilot and large scale including fermenters Soluble and membrane proteins including synuclein Protein purification using kta Biorad systems including reverse phase chromatography Protein analysis using SDS PAGE and Western Blot , dialysis and concentration determination Protein characterization techniques Microscale thermophoresis MST , fluorescence anisotropy , Far Western Blot , surface plasmon resonance SPR , circular dichroism spectroscopy CD , dynamic light scattering DLS , nano differential scanning fluorimetry nanoDSF , ELISA , HCP and gyrolab , crystal screen and optimization , negative stain electron microscopy , small angle X ray scattering SAXS Currently gaining hands on experience with NMR spectroscopy Bioinformatics tools for sequence alignment , UniProt , Swiss PDB , pymol , and ATSAS . Gaining experience on NMR data acquisition and analysis tools . Technologies : Xray;SLS DLS;SPR;MST;DSF;CD;NMR;FP

proteins;characterization;engineering;expression;interaction

Senior Director , Computational Biology . . . Technologies :

Chief Scientific Officer . www.interxinc.com . . Technologies :

Staff Scientist , Computational Biology . Exai Bio is developing a unique RNA based liquid biopsy for early detection and monitoring of multiple cancers . . Computational Geneticist Studying Cancer Genomics . PhD in physics experimental condensed matter . Extensive experience in experimentation , statistics , data analysis , machine learning , and thinking about the big picture . You can find my publication list on google scholar : https : scholar.google.com citations user mcBYLM8AAAAJ hl en . Technologies :

Scientist Protein Analysis . Binding Analysis between Antibodies and Antigens . Biolayer Interferometry Octet Red96e . Antibody Screening . Development and Establishments of Methods for Incoming Goods Control . ELISA , Western Blot , Native PAGE , Isoelectric Focusing . . Technologies : BLI

antibodies;interaction;screening

Medical Specialist Project Leader . . 10 years experience as a pharmaceutical researcher with innovative mindsets and solid expertise in design of advance delivery systems nanomedicines via pulmonary , oral and parenteral routes to tackle the biological barriers and unfavorable properties of biotherapeutic agents e.g. peptides , siRNA ; Substantial experience in a variety of pharmaceutical technologies e.g. spray drying , freeze drying for solid formulation development guided by QbD tools , e.g Design of Experiments DoE , and Process analysis Technology PAT ; Well trained and experienced project leader manager with proved track record of the management of early research projects , as well as the commercial development project ; Optimistic , easy going , self motivated , and learning fast .. Technologies :

biologics;developing

Professor Phd . Own research My research group is focusing on 3D structure determinations of ion channel receptors in the central nervous system . We are one of the leading groups in the field of ionotropic glutamate receptors iGluRs and can now produce ligand binding domains LDBs of nine different iGluR subunits for structural studies . The group accounts for 20 of all structures of iGluRs deposited in the Protein Data Bank ; i.e. 70 in year 2016 . This significantly advances our ability to perform structure based ligand design of iGluR targeting compounds . In 2008 2013 , I functioned at Head of GluTarget , a project initiated under the Programme of Excellence at the University of Copenhagen . The aim was to obtain novel structural and functional understanding of iGluRs at the molecular level by integrating multidisciplinary technologies and expertise ranging from biostructural studies over medicinal chemistry and chemical biology to pharmacology . This constellation was quite unique in Europe and has received very positive international evaluations . Extensive experience with national and international collaborations exists in the group . In 2008 , we also initiated structure determination of Cys loop receptors and in 2016 neutron macromolecular crystallography NMX on iGluRs a new method to be introduced in Denmark . Expertise Structural biology on soluble and membrane proteins including recombinant expression and purification , biophysical characterization e.g. isothermal titration calorimetry , protein X ray crystallography use of synchrotron radiation sources , analysis of protein ligand and protein protein interactions , structure based ligand design , ionotropic glutamate receptors . . Academic Degrees : 1986 , M.Sc . pharm . , The Royal Danish School of Pharmacy RDSP 1988 , PhD , The RDSP Cheminova Agro A S Employments : 1986 1988 , Industrial PhD student Erhvervsforsker , The RDSP Cheminova Agro A S 1988 , Teaching assistant , Dept . of Organic Chemistry , The RDSP 1989 1992 , Post doc , Dept . of Medicinal Chemistry , The RDSP 1993 1994 , Senior scientist , Dept . of Medicinal Chemistry , The RDSP 1995 2008 , Associate professor , Dept . of Medicinal Chemistry , The Danish University of Pharmaceutical Sciences 2008 2016 , Professor MSO in structure based drug design , Dept . of Medicinal Chemistry , University of Copenhagen KU 2016 present : Professor in experimental structure based drug design , Dept . of Drug Design and Pharmacology ILF , University of Copenhagen KU Major Committee Assignments : 1999 2002 : Member of Board , the Dansync Center for synchrotron radiation 2002 2008 : Member of departmental board , Dept . of Medicinal Chemistry , DUPS and Deputy Head 2004 2008 2004 2012 : Member of Academic Council , DUPS and KU 2004 2006 : Member of committee for defining central and prioritized research areas , DUPS 2005 2007 : Member of scientific committee , Dept . of Medicinal Chemistry , DUPS 2007 : Member of committee for preparation of strategy plan 2007 2010 , PHARMA , KU 2007 2012 : Director of Drug Research Academy , an industry oriented research education programme at DUPS KU 2008 2013 : Head of GluTarget , project within the Programme of Excellence at KU . 24.5 mio . kr 2010 2012 : Member of board , SHARE 's Cross Faculty PhD Initiative , KU 2010 2012 : Coordinator of mobility PhD grant on project Ion channel receptors in brain diseases 2012 present : Member of Research and Innovation Committee , ILF , KU 2015 2018 : Appointed Member of The Danish Council for Independent Research , Natural Sciences FNU and member of Executive Committee 2017 2018 2016 : Member of the PIPPI Advisory Board , an Innovative Training Network ITN under Horizon 2020 , DTU . Technologies : Xray;ITC

membrane proteins;characterization;expression;interaction;stability;structure

Postdoctoral Researcher . . Chemical and structural biologist with experience in cryo EM , translating targeted protein degradation to bacteria .. Technologies : CryoEM

molecular glues;proteins;structure

Director of Bioinformatics , Biologics Engineering . To lead the development of an end to end data management and analysis strategy and capabilities that will significantly impact the delivery of the novel biologics drugs of the future . Biologics Engineering is responsible for the discovery and optimization of next generation and novel biologics across all AstraZeneca therapy areas , providing innovative drug discovery capabilities to drive portfolio drug projects . . Innovator with the ambition to make genetically programming cells a reality in the true sense of the word programming , by precisely predicting how changes to the genetic code of a cell will affect its behaviour . Pioneer in the development of programming languages for molecular and genetic circuits , which automatically generate computational models of behaviour from annotated DNA sequences . Leader in Synthetic Biology with experience leading high performing multidisciplinary teams at the intersection of computational modelling , lab automation and machine learning . Led research on learning computational models of cell dynamics from experimental data and on predicting interactions between DNA molecules from sequence . Inspired by the potential of combining machine learning methods with domain knowledge in the form of automatically generated computational models , to predict the behaviour of a cell from changes to its genetic code . https : ph1ll1ps.github.io . Technologies :

Senior Scientist . Protein Therapeutics API Development . Promote the development of innovative digital technologies and manage process optimization activities for the manufacture of monoclonal antibody therapeutics . Responsible for leading the Advanced Process Control BTDS group that uses process analytical technology such as Raman spectroscopy and MVA modeling analytics to promote the transformation of drug substance production processes into a digital manufacturing platform .. Technologies :

biologics;developing

Research Scientist . . Researcher in Molecular Biology and Biotechnology . Did a 4 year Post doc . at NTNU Biotechnology in the field of Structural Biology and Protein Crystallography , with an 11 months visit in the Macromolecular Structure Group headed by Mirek Cygler , Montreal , Qc Defended my Ph.D. thesis entitled Structure Function Analyses of Mannuronan C 5 epimerases A Family of Modular Type Enzymes with an Applied Potential in january 2004 . My current ambition is to continue doing Molecular Biological research . Specialties : Standard molecular biology and microbiology techniques including e.g. DNA extraction and manipulation , PCR , protein purification and crystallization , etc .. Technologies : Xray

proteins;structure

Director , Bioinformatics Research Group . My group develops bioinformatics software and databases to accelerate scientific research , including the Pathway Tools software , and the EcoCyc and MetaCyc databases . . . Technologies :

Principal Scientist . . Protein biochemists and structural biologist with 10 years of experience of protein construct design , expression , purification and structure and biophysical characterization , managing multiple research projects in following areas : Protein structure biology Protein expression and purification Protein engineering Membrane protein biochemistry and biophysics Technical Skills Protein construct design and screen : Cloning General molecular biology procedures including PCR , restriction enzyme , LIC , Gibson assembly , mutagenesis , etc . , FSEC Protein expression : E.coli , Mammalian cell HEK cell with baculovirus , Hybridoma , insect cell SF9 , Hi5 , and yeast Pichia , Saccharomyces Protein purification : AKTA systems Affinity , IEX , SEC , protein A , etc . , HPLC Protein characterization : Circular Dichroism CD , SEC UV MALS RI , Isothermal Titration Calorimetry ITC , SDS PAGE , Western blot , Silver staining , Pull down assay , MALDI TOF Protein Structure : X ray crystallography manual and robotic crystallization , synchrotron data collection and analysis , experimental phasing and molecular replacement . Program : CCP4 suite , HKL2000 , XDS , Phenix , coot , pymol , chimera , Small angle X ray scattering SAXS , Negative Staining , Cryo EM Program : EMAN2 and relion , modeling Modeller . Technologies : Xray;CryoEM;ITC;CD

membrane proteins;proteins;characterization;engineering;interaction;stability;structure

Biomedical researcher . . RESEARCH EXPERIENCE . Biosensor design for hapten detection 2011 2013 . Biosensor design for albumin detection 2011 2013 . Magnetic nano gold particle synthesize 2011 2012 . Biosensor design for cancer biomarker epidermal growth factor receptor detection 2013 2014 . Lateral flow design for screening EBV VCA specific IgA in nasopharyngeal carcinomas 2014 2015 . Lateral flow design for Screening of IgA Deficiency 2014 2015 . Biosensor design for DNA methylated detection 2018 2019 . Biosensor design for glucose detection 2017 2019 . Biosensor design for HbA1c detection 2017 2019 . Lateral flow design for Screening of Covid 19 2020 . Biosensor design for cTnI detection 2021 . PROFESSIONAL EXPERIENCE . Medical laboratory expert Full time : 2011 2013 . Imam Khomeini Hospital , Tehran , Iran . Quality control manager Full time : 2013 2015 . Quality control of biochemistry kits in Man company , Tehran , Iran . Quality control consultant Part time : 2015 2020 . Quality control consultant in Man company , Tehran , Iran . Production Manager Full time : 2020 . Production manager in Arvin BioHealth , Tehran , Iran . TECHNICAL SKILLS . Microsoft Office . Photoshop . Fabrication and Modification of Sensors and Biosensors based on : . Electrochemical . Electrochemical Impedance Spectroscopy . Electrochemiluminescence . Field Effect Transistors . Lateral Flow . Cellulose Fiber Production by Electrospinning . Antigen and Antibody Immobilization on Biosensor Surface PVA , Tiophen , Reduced Graphene Oxide . Gold Nanoparticles Synthesis Using Various Kind of Reducing Agents such as Sodium Citrate , Tannic Acid , and Glucose . Iron Oxide Nanoparticles Synthesize Ammonia and NaOH . Core Shell Fe Au Nanoparticles Synthesis . Core Shell Fe Chitosan Au Nanoparticles Synthesis . Carbon Dot Synthesis . Silver Nanoparticles Synthesis . MOF Synthesis . Au nanocluster Synthesis . Protein Concentration Assay Bradford . Cell culture . Bacteria Culture . Polymerase Chain Reaction PCR . Electrophoresis Agarose gel . Blood Sampling . Medical Biochemistry Techniques . Elisa Technique . Medical Laboratory Expert Biochemistry , Immunology , Microbiology . Quality Control Techniques Accuracy , Precision , Recovery , Linearity , LoB , LoD , T Test . Method Validation . GMP . Quality Policy . ISO 13485:2016 . Technologies :

Director Of Bioinformatics . . Accomplished leader of technical and scientific teams in bioinformatics and computational biology with strong and diverse background in research and development , project management and customer support . More than ten years of experience in developing and applying computational methods and tools for analysis of genomic and molecular data . Cancer and Viral Genomics . Expertise in cancer genomics and epigenomics , variant calling including SNV , indwells , CNV and fusion , patient stratification , pathway analysis , machine learning , univariate and multivariate regression , feature selection , overall survival and recurrence analysis . Experience in identifying biomarkers and disease associated targets by multi data type integration via using public and proprietary data . Clinical trial data support , resistance monitoring and analysis . Extensive experience in statistical analysis , technical writing as well as customer and marketing support . Strong background in statistics , biophysics and molecular , structural and genome biology . High proficiency in Perl including bioperl , Python including Django , C C , awk , Windows and UNIX platforms . Working knowledge in R Bioconductor , JMP , Pipeline Pilot , SQL query and database development and validation including Oracle SQL developer . Experience in management of internal and external collaborations and projects . Self driven , focused and highly skilled in bringing scientists together from different disciplines to achieve goals and bridging knowledge divides among them . Comfortable with multitasking in a fast pace environment while delivering high quality results to meet deadlines . Specialties Bioinformatics , virology , oncology , next generation sequencing , digital PCR , genomics , epigenomics , transcriptome analysis , ultradeep sequencing , customer support , molecular and structural biology , atomic force microscopy , high throughput data analysis , relational database management system .. Technologies :

Senior Researcher . . I am a neuroscientist with more than 15 years of both industrial and academic experience in in vivo and in vitro models of pathological protein aggregation in neurodegenerative diseases , transgenic technologies such as somatic transgenesis with viral vectors and CRISPR Cas9 , and preclinical project management . Experienced Senior Researcher with a demonstrated history of working in the pharmaceuticals industry . Skilled in Molecular Genetics , Molecular Neuroscience , Flow Cytometry , Microscopy , Creative Problem Solving , Collaborative Problem Solving , and Biophysics . Strong research professional with a Doctor of Philosophy Ph.D. focused in Biochemistry and Molecular Biology from University of Helsinki .. Technologies :

idps

Scientist I , Computational Chemistry . . . Technologies :

Senior Research Scientist . Delivery expertise in the area of construct design , recombinant protein expression , purification and characterisation to facilitate drug discovery projects . Delivering high quality , tailor made protein for assay development , crystallography , HTS , SPR , NMR and DNA encoded library screening . Collaborating with multi discipline team to facilitate the success of drug discovery projects . Developing and prioritising work plans over agreed timelines to meet the objectives of the project . Establishing semi automated processes for rapid protein production . Maintaining awareness of current developments and evaluating new technologies to continuously improving team s capability . Mentoring students to accomplish new scientific discoveries . Advocating the value of inclusion diversity . . I love to push scientific boundaries to develop efficient process and drive drug discovery project forward . To accomplish this , I focus on identifying key results , meeting timelines , open minded to new scientific innovation and tirelessly learning to wider my prospective . Specialties : Molecular cloning Recombinant protein expression , purification and characterisation Structural Biology Biophysics Automated Parallel Purification Sector Knowledge : Early Drug Discovery Research Protein Science Membrane Protein Process Designer . Technologies : SPR;NMR

membrane proteins;proteins;interaction;expression

Computational Scientist I . Group : Cancer Data Science A major obstacle for treating cancer is a lack of precision medicines . Many potential targeted therapies fail to transition from preclinical models to patients due to incomplete knowledge of the drug s mechanism of action and or absence of robust biomarkers to identify relevant patient populations . As part of the Target Discovery and Advancement arm of the Cancer Dependency Map project depmap.org , my primary goal is to provide the oncology community with potential drug targets that have a high likelihood of success . We use machine learning methods to identify molecular features mutation , expression , methylation that are predictive of sensitivity to gene target inhibition CRISPR Cas9 , RNAi . This information provides insight into the target s function in cancer , helps us to generate therapeutic hypotheses , and guides us in nominating targets that are most likely to translate to patient tumors . Collaborations : modeling hematologic malignancies using CRISPR genome engineering created analysis pipeline available via http : crispr seq.com , discovering genetic dependencies specific to pediatric cancers , and other pan cancer studies centered around functional genomics . . I 'm interested in cancer precision medicine , particularly the application of machine learning tools to therapeutic target discovery . Technologies :

Manager , Downstream MS T Senior Scientist . . MS T Downstream Senior Scientist in Biopharmaceutical Industry . Previous experience as Tech Transfer Team Lead for Cell Therapy Facility and Process Scientist in both Upstream and Downstream mAb manufacturing . MSc in Immunology , BSc in Biomedical Sciences . Cert in Biopharmaceutical Operations at National Institute for Bioprocessing Research and Training NIBRT . Record of research into tumour immunology and treatment development . Excellent interpersonal skills with the ability to develop strong relationships with colleagues and key leaders across a diverse range of scientific disciplines .. Technologies :

Scientist II , Computational Biology . . Scientist with broad domain knowledge in genomics , biology , and data science . I have in depth experience with data wrangling , advanced statistical analysis , and machine learning using R Python . This comes from a diverse background in benchwork and bioinformatics for designing and executing next gen sequencing projects . Over the years I 've built a strong track record of teamwork and collaboration with US and international teams for efficient execution of both large scale and targeted pilot projects .. Technologies :

Head of Discovery Sciences . . Passionate about innovative drug development . Highly experienced in scientific management and coaching of multidisciplinary project teams discovering biologics from inception , over proof of concept to transition into early development . Solid track record of generating multispecific therapeutic candidates to a. o. GPCRs , solute carriers and ion channels for immuno oncology , neurology , infectious and inflammatory diseases . Strong proponant of industry academia collaborations . Extensive expertise in affinity maturation , engineering and NGS based discovery of biologics . Analytical and problem solving mind set . . Technologies :

antibodies;biologics;developing;engineering

Scientific Director , Oncology Data Sciences . . More than 15 years experience conducting research in Computational Biology , Machine learning , Artificial Intelligence AI , Statistics , Genetics , and Molecular Biology Expertise in building synergistic teams , motivating individuals , and devising scientific strategies to deliver effective and innovative data science solutions for drug development Broad knowledge and experience in multiple therapeutic area including oncology , immunological diseases , rare diseases , and neurological diseases Expertise in leading conducting analysis of high dimensional OMICS data and electronic health records EHRs to impact target identification validation , drug 's MOA , patient stratification , and clinical development Expertise in identifying genetic causalities and investigating drug response in rare diseases and complex disorders from whole genome exome sequencing Biomarker expert on precision medicine Effective collaborations and communications with biologists , clinicians , chemists , statisticians , and data scientists Expertise in leading cross functional and academic collaborations with high impact publications . Technologies :

Ing nieur de recherche . Membrane Biochemistry and Transport Thomas Wollert team Department of Cell Biology and Infection . Transmission electron microscopy : Tokuyasu cryosectioning technique for immunolabeling Correlative light and electron microscopy Proficient in SerialEM , Imod and Amira software Formation Image Processing for Electron Microscopy tomography in 2021 Cryo Electron microscopy : Cryofixation on Vitrobot and Leica EMGP and Data aquisition on Glacios Cellular biology , Immunofluorescence Molecular biology : Cloning , PCR Recombinant protein expression Procaryotes and eucaryotes system Purification on akta system Chromatography Western Blot Crystal growing experiment . Technologies : CryoEM

membrane proteins;proteins;structure

Senior Scientist , Computational Biology . Support the development of clinical biomarkers and diagnostics supporting Amgen programs through the assessment of biochemical coverage , patient stratification , indication selection in Amgen s early and late clinical development programs and discovery of clinical insights at asset and portfolio levels through the application of knowledge discovery and data mining techniques Represent the clinical biomarkers diagnostics team in Amgen program portfolio teams as a biomarker analysis lead Develop tools for data integration , management , visualization , analysis and presentation and provide leadership and expertise in those domains . Bioinformatician and quantitative thinker with experience developing and communicating efficient algorithms and statistical modeling pipelines for integrative analysis of large scale genomic and biomedical datasets .. Technologies :

Undergraduate Research Assistant . Research Assistant for Professor Volker Vogt and Dr. Robert Dick in the Department of Molecular Biology and Genetics in the College of Agriculture and Life Sciences at Cornell University . Analyzed the molecular structure of Jaagsiekte Sheep Retrovirus JSRV and other retroviruses in vitro utilizing single particle cryo electron microscopy . Conducted viral release and infectivity studies in vivo utilizing immunoblotting and flow cytometry instrumentation . Proactively communicate with other scientists to clearly describe project objectives and results as part of Cornell University 's Molecular Biology and Genetics REU program . . Detail oriented honors student with a passion for resolving current health related problems . Experienced in sterile lab technique and microscopy . Eager to develop creative problem solving abilities through expanding my research experiences . Adept at learning new communication techniques and laboratory practices .. Technologies : CryoEM

proteins;structure

Senior Research Scientist . . Experienced CMC Senior Scientist , Analytical development and characterisation Analytical development of small molecule , peptide and protein drugs from Pre clinical to Early Late Phase Development Acting as analytical responsible within global development projects Performing monitoring reporting method development , method validation and stability testing Specification setting Performing impurity degradation product investigations Performing forced degradation studies and candidate drug evaluation Outsourcing development GMP analytical testing to external partners Compiling reviewing CMC regulatory documentation Performing preformulation work and formulation screening Acting as Principal investigator for GLP formulation analysis , outsourcing GLP work . Technologies :

peptides;proteins;characterization;stability

Scientist and project leader . Scientist and and project leader within Nouryon s agricultural section . Fredrik focuses on innovaiting biodegradable surfactants polymers for the agricultural society . . Fredrik Andersson is a self motivated scientist with social competence and experience as project manager and commercial roles . 15 years experience from the Life Science Chemistry field both in academia and industry on a national and an international level . Superior know how in the below skills : Protein Science and biophysics Research Surface chemistry Surfactants detergents polymers Project management Technical sales Product development . Technologies :

proteins;characterization

Computational Scientist II . . . Technologies :

Senior scientist Antibody discovery . Discovery and development of therapeutic antibodies to interrupt pathological fibroblast driven immune signalling . . Technologies :

antibodies;developing

Doctoral Researcher . Application of cryo electron tomography cryoET subtomogram averaging STA to elucidate molecular structures in mammalian cells for biomedical research Institute of Neuropathology RG Prof. Dr. Fern ndez Busnadiego . Any sufficiently advanced technology is indistinguishable from magic . Arthur C. Clarke . Technologies : CryoEM

proteins;structure

Product Owner . Since January 2020 I have taken the role as Scrum Product Owner , leading development of the software for an upcoming instrument . As user friendliness is one major driver for the overall project , I coordinated a team designing the UX in advance of the project start . I also participate in coordinating with the hardware project as acting Product manager for this development project . Using my experience from Application Development and Customer Support really helps me driving the user requirements and aligning the development teams towards those goals . . As an Innovation development specialist , I bring science and technology ideas out of their bubble to transform them into useful and needed products and methods . Activities I am involved in include : Developing Technology and applications in biophysics and surface science Supporting future growth into key application areas by building networks and scientific knowledge Developing instrumentation and methods to facilitate novel biochemical experiments Optimizing prototypes for usability , reliability and robustness . Technologies :

Team Leader Chemistry . Team leader for a team of synthetic chemists . Lead chemist responsible for progressing the chemistry program in projects from hit identification up to lead optimization . Project leader for a drug discovery program leading a multidisciplinary science team during lead identification . . Research interests : Phenotypic screening and how more relevant in vitro screening systems can be applied to aid hit identification and compound optimization . Application of computational chemistry methods to facilitate drug discovery research in particular around structure based drug design and modeling protein ligand interactions for GPCR and nuclear hormone receptor targets .. Technologies :

membrane proteins;small molecules;interaction;screening

Research Scholar : Computational Biology . Research Project : DNA codes within non coding regions of the human genome . I hold a bioinformatics computational biology PhD , and possess strong analytical and experimental design skills . I am self motivated , independent and creative . My expertise is in transcription regulation , and my goal is to study this by deriving biological meaning from both sequence and genomic data . I have a wide skill range , from C programming and Python in the Linux environment , to data analysis and interpretation . . Technologies :

Undergraduate Researcher . Researcher at Dana Farber Cancer Institute Harvard Medical School Developing methods to impute gene expression into GWAS data to identify gene disease associations Leveraging both Allele Specific Expression and eQTL Data to deduce SNP gene relationships Working with Python , R , Celery , ASE Data , eQTL Data . PhD student at Stanford University interested in computational biology research . Technologies :

Senior Bioinformatics Data Scientist . . I am a programmer , a data scientist , a computational and experimental biologist . I am interested in data science , bioinformatics , and human genetic research .. Technologies :

PhD Fellow . Identification of lipid changes associated with Parkinson s Disease and alpha synuclein pathology in dopaminergic neuronal cells A GBA KD model is developed in SH SY5Y neuroblastoma cell line . shRNA is used to introduce 50 80 KD of the GBA gene in the beforementioned cell lines . Cell line expertise : SH SY5Y , Human fibroblasts , IPSC 's , NPC 's . Passionate scientist with great interests in molecular biology , neuropharmacology and biophysics in relation to development of strategies for diagnosing neurodegenerative diseases such as Parkinsons Disease . My current research focus is to identify lipid changes associated with Parkinson s Disease and alpha synuclein pathology in dopaminergic neuronal cells . I possess a broad range of cell culturing skills , skills within molecular biology qPCR , molecular cloning , protein expression purification , enzyme assays and I have great expertise in analytical methods f.ex . Lipidomics , DNA sequencing , GCMS , HPLC , Western blot , Seahorse extracellular flux analysis , Tht aggregation experiment , Dynamic Light Scattering and Circular Dichroism . I love new challenges and I 'm constantly seaching for new ways to improve . I have experience within the pharmaceutical industry , clinical pharmacy , fundamental research , university teaching and I have nine years of lab experience .. Technologies : SLS DLS;CD

enzymes;characterization;stability

Research Fellow . . I have achieved my BSc degree in Information System , MSC in Computer Forensics and PhD in Machine learning . The outcome of this degrees has enabled me to develop skills in methodological problems , projects management analysis , computing network , security and analysing the trend of new research for the nearest future . I have experiences in the ability to work with a diverse range of people and having energy and enthusiasm in pursuing projects . I can work independently using my own initiative or as part of a team , problem solving , events management , excellent communication and time management skills , numeracy competence and understanding of numerical data , statistics and graphs .. Technologies :

Senior Scientist , Computational Chemistry . . I am a computational chemist working in working in the field of computer aided drug design . Proficient in both ligand and structure based methods with a specialization in docking , virtual screening , molecular dynamics , and free energy methods . . Technologies :

Associate Professor of Structural Biology and Senior Lecturer . Structure function characterization of membrane remodeling proteins Amyloids and neurodegeneration Cryo EM and 3DEM reconstructions Mitochondrial dynamics and cell death . We 're recruiting another postdoc if you are interested in working with cryo EM helical amyloid processing with awesome colleauges in an exciting environment , contact me . Technologies : CryoEM

idps;characterization;structure

Principal Scientist Discovery and Development PK PD . . Accomplished scientist with more than 20 years of experience leading teams and providing PK PD and DMPK support , including modelling and human dose PK predictions from Hit to Lead to the clinic Previous experience supporting programs in metabolic disease , CNS , dermal , infectious disease , antibacterial and diseases of the Developing World malaria , TB and kinetoplastids PK Project Representative on multiple programs focusing on metabolic therapeutic disease areas Obesity and Diabetes Formulation development for biological , pharmacological , metabolic and toxicological studies in rodent and higher species dog , minipig and monkey Formulation development to drive product decisions i.e. salt selection , soft gel formulation and enteric coating for preclinical capsules Responsible for providing in vivo support for pharmacological , toxicological and pharmacokinetics preclinical studies Responsible for providing bioanalytical , in vitro and in vivo support for early discovery candidates Specialties : Project management for DMPK and Pharmacology Leader , mentor and teacher for support staff , including projects and small teams of bioanalytical and junior DMPK staff Preclinical DMPK and human dose prediction modelling including PBPK modelling GastroPlus In vivo work with rodents and dogs including brain uptake experiments , tissue distribution and metabolism studies In vitro experiments to support modelling and preclinical candidate progression Expert end user for multiple mass spectrometer platforms including Sciex and Waters Expert user on various physical characterization techniques such as DSC , TGA and PXRD Expert in formulation development for preclinical species . Technologies : DSC