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Principal Scientist , Translational Biomarker Flow Cytometry , TME TRC Translational Development . . While my day job revolves around utilizing my 10 years of flow cytometry expertise to advance clinical programs , I am truly passionate about supporting employees to develop professionally and personally . I believe in the mission of employee resource groups as a means of generating the psychological safety necessary for scientists to feel comfortable sharing their ideas and concerns , generating more efficient and innovative teams . Technologies :

Senior Scientist , Advanced Drug Delivery , AstraZeneca . . Curious and hands on scientist interested in developing novel technology to solve challenging real world problems . I have been working on multidisciplinary projects on the development of affordable , easy to use , disposable diagnostic devices for disease monitoring and management at the Point of care PoC . I am also working on the development of handheld sensors for monitoring levels of contaminants in drinking water . During my PhD and Post Doc have developed assays and biosensing platforms for studying the function of membrane proteins in a native like environment . My interests in solving challenging scientific questions are broad and worked on nanotoxicology , developing assays for the toxicity of ZnO nanoparticles to cells .. Technologies :

membrane proteins;developing

Senior Bioinformatician . Vertebrate Resequencing Informatics . . Technologies :

Bioinformatician , Centre for Chronic Disorders and Diseases C2D2 . C2D2 is a cross disciplinary initiative funded by the Wellcome Trust and aims to reduce the burden imposed by chronic diseases and disorders by providing strategic support for research . It brings together staff from the Departments of Biology , Health Sciences , Mathematics , Computer Sciences , and more , fostering new partnerships and enabling exciting new research in this important field . . After studying bacteriology during my undergraduate degree , my Ph.D. combined in vitro and in silico analyses of the bovine respiratory pathogen Pasteurella multocida , specifically the role of iron acquisition in bacterial virulence . The work resulted in a new model of the way in which iron availability influences the virulence of the bacteria in the bovine respiratory tract . Building on the theme of host microbe interactions , my postdoctoral work investigated the metabolic symbiosis between the pea aphid and its bacterial symbiont Buchnera . Exploiting an in silico metabolic model of the bacteria , we built a model of the specialised aphid cells , the bacteriocytes , in which the bacteria are housed . Close collaboration with Angela Douglas ' lab at Cornell University provided next generation sequence data , transcriptomic data , proteomic data and metabolic data to inform the model building . Recently , I 've completed a Masters degree in Computational Biology at the University of York , broadening my range of bioinformatics and data analysis skills . As part of this , I worked in the lab of Toni Gabaldon at the Centre for Genomic Regulation in Barcelona , building a genome scale phylogeny of the tsetse fly . Currently , I am working as a bioinformatician as part of the Centre for Chronic Diseases and Disorders C2D2 initiative at the University of York . I provide bioinformatics expertise to researchers working across the University as part of this cross disciplinary and cross departmental initiative . Specialties : host microbe interactions , systems biology , construction of in silico metabolic models , SBML Systems Biology Markup Language , flux balance analysis , flux variability analysis , gene deletion analysis , genome annotation , next generation sequence analysis , SNP analysis , data parsing , Python programming , database design and implementation , phylogeny . Technologies :

Senior Scientist . . Cryoelectron microscopist over five years of experience and four high resolution structures solved with a passion to discover new protein structures and expand available therapeutics Skills : Cryo EM grid preparation , data processing using various software such as Relion , CryoSparc , EMAN2 , Scipion , Xmipp , among others , TEM operation and alignment Arctica , Krios , Jeol , BioTwin Spirit using EPU and SerialEM , model building using PHENIX and COOT . Computation Shell Python scripting , Matlab Octave , familiar with HPC environment such as PBS , basic machine learning , molecular dynamics using Amber and NAMD , protein structure prediction using Rosetta and various bioinformatics tools Biochemistry Design and optimization of assembly reactions of protein complexes in stable states , gel filtration using AKTA systems Personal experience : The first project that I was able to use my cryo EM skills in a health oriented target was the determination of the high resolution structure of the human immunoproteasome . To put in context the importance of this particular protein , it is a key target in the treatment of patients with multiple myeloma , B cell autoimmune disorders and rejection of organ transplant recipient . Although there were several challenges in the project , the importance of not only obtaining the first structure of this target but also revealing the mechanism of which a new , versatile small molecule scaffold interacted with the protein fueled my passion . . Technologies : CryoEM

proteins;structure

Director , Research and Discovery . . I see myself as highly dedicated to all endeavors I undertake , and with a true passion for working with molecular pathophysiology in an entrepreneurial environment , from the conception of new therapies to commercialization . This drive has taken me from an initial start up focused on heart disease , to the completion of an industrial Ph.D. in structural biology within bleeder s disease . I recently augmented my scientific background by completing a M.Sc . BA in Bioentrepreneurship at Copenhagen Business School . This combination of drive , experience and educational background translates into a focus on detail , while ensuring the timely generation of high quality scientific data that facilitates innovative solutions . In my leisure time I enjoy hiking , diving and hunting while travelling as much as time allows . Teamwork oriented High academic skill level Biopharmaceutical development . Technologies :

biologics;developing;structure

Staff Software Engineer in Research . . I m a software engineer working in research at DeepMind , with a background in biology .. Technologies :

Speech and Language Therapist Assistive Technologist . . Specialties : assistive technology , disability , ICT and web accessibility , Speech and Language therapist , alternative formats and now building on the work we did for an Arabic Symbol dictionary for AAC users and those with learning or language difficulties acquiring literacy skills . We have launched Global Symbols and hope to link up many more AAC symbol sets . Also looking into AI and Inclusion as part of an Alan Turing Institute Pilot Project . . Technologies :

Senior Computational Biologist . Tech Lead , Structural Variation Team , Data Sciences Platform Methods Group I design , develop , and evaluate computational methods for processing NGS data within the Genome Analysis Toolkit GATK . Focusing on methods for structural variation detection , I develop algorithms and pipelines for accurately calling variants from sequencing data . As tech lead , I provide guidance , advice , and technical leadership to a team of computational biologists and engineers working on implementing state of the art structural variation detection methods meant for the Broad Institute 's research and clinical pipelines . Computation Biologist , McCarroll Lab , Stanley Center for Psychiatric Research I design methods and conduct analyses to better understand copy number and structural variation . My focus is on detecting and analyzing copy number variation in regions of the genome that are difficult to access with standard algorithms for processing short read data . I contribute to research projects that aim to understand complex forms of structural variation and their association with disease risk and other phenotypes . . Computational Biologist at the Broad Institute . I work on analyzing genomics data , specializing in detecting copy number variation and other forms of genomic structural variation , and analyzing how these variants are formed , segregate in populations , and affect disease biology . I write algorithms in GATK and related software projects . My PhD was in computer science , with a focus on computational biology and bioinformatics , working on projects analyzing next generation DNA sequencing data using distributed computing frameworks and machine learning . Former senior software engineer for distributed and web applications . Specialties : Bioinformatics , Genomics , Structural Variation Detection , DNA Sequencing , Cloud Computing , Machine Learning , Data Science , Distributed Computing , Spark , Internet and Web Application Development , Agile Software Development , Java , R , Python , HPC , Scala , Google Cloud Platform , WDL Cromwell .. Technologies :

Senior Clinical Informatics Scientist . . . Technologies :

Professor . http : profiles.umassmed.edu profiles display 129880 http : www.umassmed.edu mccb faculty MCCB faculty MCCB faculty profile pages zhu julie http : www.umassmed.edu mccb bioinformatics core software . . Technologies :

Vice President , Automation and Process Optimization . Heading up the Digital Science Innovation efforts to further automate across research and early development . . Protein scientist with expertise on the automation and production of proteins for structure and therapeutic discovery uses , with a particular emphasis on eukaryotic production and membrane proteins . Now focused on all forms of automation and process optimization across the R ED areas of Novo Nordisk .. Technologies :

membrane proteins;expression

Applications Manager of Life Sciences . I develop global marketing strategies to drive Life Science business growth and sales effectiveness at Gatan Inc. worldwide . I analyze emerging trends in the Life Science sector and work with product management and engineering to develop competitive strategies . . Developing global marketing strategies and improved methods for cryo electron microscopy with energy filtered direct electron detectors . Technologies : CryoEM

Principal Scientist , Computational Biology . . Subject matter expert , technical lead , and functional manager for Medical Imaging and Biomarker Analysis R D. Experience includes imaging physics , clinical applications , image analysis , and genomics . Subject matter expertise in digital pathology , nuclear medicine , X Ray and CT , functional imaging , and bioinformatics . Ability to successfully work in both , highly regulated medical device and diagnostics development and fast paced research and advanced development environments . Areas of work include research , advanced development and prototyping , requirements analysis , regulated medical device development , pre clinical and clinical validation .. Technologies : Xray

. . My specific area of research is the Molecular and Cellular Biology , Biochemistry and Pharmacology of the G protein coupled receptors and tyrosine kinase receptors . In particular , I am interested in the allosteric receptor receptor interactions within heteroreceptor complexes and their biochemical , pharmacological , and functional integrative implications in the central nervous system . The existence of heteroreceptors with allosteric receptor receptor interactions markedly increases the diversity of membrane receptor recognition , trafficking , and signaling and has become an important area for developing more selective drugs .. Technologies :

membrane proteins;interaction

Production Scientist . . I am currently a Junior Cell Culture Scientist Production Scientist at BioServUK in Sheffield . I have a Masters degree in Biological and Bioprocess Engineering from the University of Sheffield , where I graduated in September 2017 . In addition to this , I have a Bachelors degree in Biology , which is also from the University of Sheffield . . Technologies :

Principal Protein Scientist . Research scale protein production providing proteins for biochemical screening and structural biology in support of a range of Crop Protection Research CPR projects . Other activities include chloroplast preps for MoA studies and process scale protein purification to produce regulatory test substances . Recent activities over the last few years has involved establishing membrane protein screening platforms . A highly creative Principal Protein Scientist and expert in protein production with over 30 years experience in an industrial setting . Recognized industry leader in the field of protein science . Extensive protein expression experience including shake flasks and fermentors with E.coli and Yeast . Protein purification expertise in all major AKTA chromatographic platforms including Pure , Avant and Pilot . Highly familiar with all associated chromatography techniques e.g. ion exchange , affinity , SEC with a broad range of protein characterisation skills e.g. SDS PAGE , Western blotting . Good experience in molecular cloning and protein expression work with cell free , insect and mammalian expression systems . Work experience ranges from the supply of antibody biotherapeutics and test substance samples ranging from research scale to process scale production and extensive small molecule drug discovery projects including target provision for HTS , structural biology and biophysical studies . Recent activity over the last 6 years has involved establishing membrane protein expression screening platforms see publications and purifying membrane proteins for structural biology recent success has provided a membrane protein giving novel ligand bound diffracting crystals supporting SBDD . Highly self motivated individual and excellent communicator across all levels of the organisation and with external collaborators . Extensive experience working with CROs and academic groups to stay on the cutting edge of technology and expanding deliverables . Proven track record of delivering against aggressive timelines with multiple challenging projects , both in an individual and supervisory project management role .. Technologies :

proteins;characterization;expression;structure

Professor of Open Science . . A deep background in theoretical and computational Physics , coupled with a more recent move into Computational Biology . Goals To collaborate closely with experimental Biologists and with them develop an understanding , at a molecular level , of how organisms function . Specialties : Background : Computational and Theoretical Physics . Computational Biology . Protein DNA interactions . Cloud Computing . Skills : Expert C MPI , Perl and R coder . Experience of Java particularly with threads . Beginner in Python . Experience of C and ASP.NET on the Azure cloud computing platform . Analysing microarray data . Reasonably strong statistical skills .. Technologies :

Lead Biologist and Project Manager in Drug Discovery at CD3 CISTIM . . Biomedical research scientist with experience in academia and biotech industry . Background in immunology , virology , inflammation , metabolic diseases and tissue fibrosis . Expertise in development and implementation of screening assays for both enhancing R D platforms in drug discovery as well as for preclinical research with small molecules and antibodies . Proven track record in project management , successfully directing various scientific projects in international , multi site and interdisciplinary academic and industrial research teams . Enthusiastic about bridging academic and industrial partners to implement novel approaches for target discovery and development of first in class drugs . . Technologies :

antibodies;small molecules;screening

Senior Scientist . Design and synthesis of novel therapeutics for the treatment of malaria and tuberculosis . . Ph.D. medicinal chemist with more than 10 years pharmaceutical industry experience focused on the creation of novel pharmaceutical entities . Technical : Diverse synthetic background including both solution and solid phase chemistry Diverse variety of therapeutic areas including CNS , inflammation , fertility , and oncology . Key contributor in a variety of multi disciplinary teams focusing on a range of target types including GPCR antagonists and agonists , kinase inhibitors and a variety of other small molecule antagonists . Leadership : Provided technical and strategic plans to the team in chemistry driven projects ; developed Go No Go strategy on lead series to move projects forward . Team leader : time management , schedule planning , risk assessment and resource management resulting in completion of two large solid phase libraries . Responsible for mentoring a number of highly talented research associates . Communication : Worked in a wide variety of external collaborations : responsible for presenting and communicating progress and plans both internally and externally with corporate partners and CRO s. Responsible for data management of synthetic procedures , chemical compound inventory , combinatorial library compound inventory and assay results . Specialties : Drug discovery research utilizing medicinal and organic chemistry in the design and synthesis of novel pharmacological entities as well as the definition of structure activity relationships .. Technologies :

small molecules;developing

Research Scientist , Bioinformatics . Data science lead and support for discovery research in immunology , inflammation and fibrosis . Extensive analysis of single cell and bulk RNA seq datasets pre clinical models , clinical trials data to evaluate targets of interest . Building in house single cell RNA seq data visualization tools for enabling quicker data driven decisions . Developed novel strategy for patient stratification using machine learning methods . Managing and supporting academic and external collaborations to support target ID and evaluation . . I am highly accomplished computational data scientist with 6 years of experience in cancer genomics , machine learning and protein structural biology . I am interested in using high throughput omics datasets genomics proteomics to develop analytical pipelines for biomarker discovery and personalized cancer therapy using systems and machine learning approaches . I 'm looking to connect with people in related fields and explore opportunities . Areas of expertise : : RNA Seq bulk single cell , Proteomics , Bioinformatics , Machine learning , proficient in Python , R , Perl . Technologies :

Co Chair Metro New York Chapter . Women In Bio is an organization of professionals committed to promoting careers , leadership , and entrepreneurship for all women in the life sciences . Yana Zorina , Ph.D. is a translational cell biologist with 15 years of experience in neuroscience , signal transduction , systems biology , and oncology in academia and industry . She has in depth expertise in cell signaling , biochemistry , molecular pharmacology , mechanism of action studies , high throughput assay development and screening , and translational research . During her graduate and postdoctoral studies , Yana worked on developing a poly pharmacological treatment for acute central nervous system injury and delineated the signaling mechanisms that regulate neuronal differentiation and axonal regeneration . Yana then moved to a biotech company , whe s investigated the mechanism of action of a remyelination promoting antibody for multiple sclerosis . During this time , Yana has led preclinical mechanism of action studies , developed in vitro assays for lot release potency testing and managed several large collaborations at academic institutions and CROs . In her current position at MSKCC , Yana performs high throughput and high content image based screening , using RNAi and drug libraries to identify novel drug candidates and targets . Taken together , Yana has over 15 years of experience in biomedical sciences that ranges from basic research to drug development . . Technologies :

proteins;screening

Student Internship . Intern at the Pharmaceutical Development Biologicals Department Task : Evaluation of predictive parameters for protein storage stability and evaluation of a new device for the Measurement of Intrinsic Fluorescence and Dynamic Light Scattering . . . Technologies : SLS DLS

proteins;stability

Bioinformatics Scientist . Support new product introductions NPI , focusing on sequencing and analysis strategies for oncology , inherited diseases , pathogen identification and other novel applications Translate new product requirements into prototype and production level software Support new panel development and monitor performance of existing products Employ data mining and machine learning for system improvement and troubleshooting Work closely with molecular biology , product management and bioinformatics colleagues current official title is Sr Manager , Bioinformatics . 15 years experience collaborating on multidisciplinary research projects . Expertise in data analysis , bioinformatics , mathematical modeling , operations research , statistics , computational biology , machine learning , algorithm development , optimization , differential equations , numerical analysis and software development . Also knowledgeable about : molecular biology , biochemistry , virology and immunology , systems biology , populations genetics . 20 years programming experience , including : Python , C , MATLAB , SQL , R , Java , Perl , IDL , shell scripting , Pascal , Fortran , Visual Basic , and Smalltalk object oriented language . Experience writing about and presenting complex subject matter in an understandable way to varied audiences with both technical and nontechnical backgrounds . Highly motivated and passionate about applying computational methods in the sciences . Track record of adapting to evolving company project needs .. Technologies :

Laboratory Scientist . Cancer research at the Cryo EM laboratory . . Technologies : CryoEM

structure

Freelance researcher . Have brain , desire to use it to help banish Alzheimer 's , semi retired so flexible and available now . . Desired position An intellectually challenging role as theorist analyst project manager in a programme contributing to our understanding of neurodegeneration and or ageing . One novel approach would be an AI research project aimed at complementing enhancing our problem solving capacity ... Previous career roles Freelance tutor HNC D computing , A level psychology and GCSE science 2002 2004 . Software developer to project manager commercial software , IT industry 1979 2001 . Academic papers Wilson RJ 2009 Kinesin s walk : springy or gated head coordination BioSystems 96 , 121 6 Wilson RJ 2008 Simulating the Kinesin Walk : a Small Step towards Understanding Dementia . IEEE UKSim European Symposium on Computer Modelling and Simulation , 226 31 Wilson RJ 2008 Towards a cure for dementia : the role of axonal transport in Alzheimer s disease . Science Progress 91 1 , 65 80 Qian M , Zhang X , Wilson RJ , Feng J 2008 Efficiency of Brownian Motors in terms of Entropy Production Rate . EPL 84 1 , 10014 Harris RL , Musgrave G , Wilson RJ 1981 The design and implementation of a waveform description and test programming language for CAD of digital systems . IEE Electronic Design Automation Conference , 203 7 . Brunel MSc dissertation Wilson RJ 1978 Cyclic behaviour in some autonomous sequential networks . MSc dissertation , Brunel University , UK simulation of recurrent , weightless , artificial neural network for unsupervised pattern recognition . Other publications Wilson RJ 2000 Two articles : Cognitive Psychology and Cognitive Science , in Microsoft s Encarta encyclopaedia millennium edition Wilson RJ 1998 Book review of Aleksander I 1996 Impossible Minds , My Neurons My consciousness , Imperial College Press : London . Journal of Consciousness Studies 5 1 , 115 6 . Specialties : Scientific research , team and project management , problem solving and analysis , software design and development .. Technologies :

Principal Scientist , BioMedicine Design . . I work at BioMedicine Design at Pfizer where I m responsible for discovery of antibodies and design of various modalities for new therapeutics . I lead several discovery programs in oncology . How did I get here I m inherently interested in integral membrane proteins , conformational heterogeneity and how to capture it by structural means . Another aspect I love is understanding conformation function relationships . Turns out , antibody phage display is a great way to make specific binding domains that can be both used in structural biology and in potential therapeutics . I m very lucky to be able to contribute to a wonderful team of talented colleagues , exchange ideas with experts in their fields , and interact with multidisciplinary teams to bring novel medicines that can ultimately change patients lives . I love what I do . Technologies :

antibodies;membrane proteins;developing;interaction

Chief BioMedical Scientist . Apply medical data and clinical knowledge driven learning methods on clinical multi omics to solve clinical challenges as well as study mechanisms of actions in human diseases by multi omics methods , including single cell omics . . As a leading expert in biomedical data science and administrative member in industry with more than 13 years working experience , my personal interests focus on developing high dimensional data solutions in medicine . By means of machine learning , bioinformatics and computational biology , my team is exploring the mechanism of aberrant biological events in human diseases and seeking potential medical interventions , including 1 knowledge and data driven decision making strategies in clinical scenarios ; 2 multilayer data analysis , visualization , interpretation and summarization by combining phenotype and genotype data ; 3 commercial and open source products development ; 4 consulting for fundamental research and clinical applications . I am also one science enthusiast with extensive experience on performing and administrating cloud based data driven projects in biology and medicine by building , developing , leading and coordinating dynamic teams . Select 4 peer review publications from more than 20 publications 1 . Alhasan AH , Scott AW , Wu JJ , Feng G , Meeks JJ , Thaxton CS and Mirkin CA . A Circulating MicroRNA Signature for the Diagnosis of Very High Risk Prostate Cancer , Proc Natl Acad Sci U S A 2016 Sep 20;113 38 : 10655 60 2 . Bhattacharyya S , Wang W , Morales Nebreda L , Feng G , Wu M , Zhou X , Lafyatis R , Lee J , Hinchcliff M , Feghali Bostwick CA , Lakota K , Scott Budinger GR , Raparia K , Tamaki ZT and Varga J , Tenascin C is a key factor driving persistence of organ fibrosis , Nature Communications , 2016 Jun 3;7:11703 3 . Yan X , Sablok G , Feng G , Ma J , Zhao H and Sun X. nagnag : Identification and quantification of NAGNAG alternative splicing using RNA Seq data . FEBS Lett . 2015 Jul 8;589 15 : 1766 70 . 4 . Bao R , Huang L , Andrade J , Tan W , Kibbe WA , Jiang H and Feng G corresponding author , Review of Current Methods , Applications and Big Data Management for the Bioinformatics Analysis of Whole Exome Sequencing , Cancer Informatics , 2014 Sep 21;13 Suppl 2 : 67 82 . .... Technologies :

Scientist II . . Thanks for exploring my profile . After an unforgettable experience teaching science and coaching robotics at a public high school , I m back doing scientific research at Relay Therapeutics . I m happy to be collaborating productively with smart , fun colleagues while building computational models to enable our discovery platform .. Technologies :

Senior Scientist . . . Technologies :

Research Lead Computational Genomics , Research Staff Member . . Computational Life Sciences , Bioinformatics , Genomics , AI , Machine Learning , Software as a service , Cloud Computing , Data services and management , Analytics , Team Leadership , Planning and Strategy . Technologies :

Professor and Director . Member of the MHH Senate , Speaker of the professorial group 2011 2013 , 2015 2019 Member of the Board of Directors of the Centre for Structural Systems Biology , Hamburg Editor of FEBS Letters Editor of FEBS openbio . Dr. Dietmar Manstein is Professor and Chair of the Institutes for Biophysical Chemistry and Structural Biochemistry at Hannover Medical School . The objective of his work is the characterization of molecular motors and proteins that regulate dynamic changes of cytoskeletal and membranous structures . The coordinated generation of movement and force is essential for basic processes such as cell division , chromosome segregation , endocytosis , exocytosis , axonal transport , and muscle contraction . His experiments address the role of isoform specific differences , disease causing mutations , and drugs by integrating information derived from examining contractile events at several levels of organization . At the single molecule level , the work examines the basic design and function of the molecular motors , actin filaments , and regulatory proteins using highly sensitive and fast techniques to follow chemical , spectroscopic , and mechanical changes . These studies are usually combined with protein engineering and high resolution structural analyses . The determination of three dimensional structures of bio macromolecules and their complexes with small ligands is performed using X ray crystallography . The results of these measurements provide insights into the catalytic mechanism of enzymes , the mode of action of small molecule effectors , and support the development of therapeutic drugs . Hybrid approaches , which combine analysis by X ray crystallography with cryo electron microscopy or the analysis of hydrodynamic properties , are used to solve the structures of larger protein complexes . Here , the results can provide insights into long range communication pathways , regulatory mechanisms , and the effects of disease causing mutations . At the level of isolated cells , his research program uses the information gained from kinetic and structural studies , to address the role of proteins in supporting motile functions and the potential of small ligands as therapeutic drugs .. Technologies : Xray;CryoEM

proteins;characterization;engineering;interaction;structure

Senior Scientist . . My favorite part of science is when big data meets big analysis . I m a PhD trained molecular biologist with extensive experience generating large scale genomic and proteomic datasets , but thanks to my additional background in engineering , I ve also developed the computational skillset needed to analyze these large scale datasets . As such , I m just as comfortable sitting at my lab bench pipetting reagents I need for an experiment as I am sitting in front of my computer trying to find creative ways to make sense of new data . Collaborations with others is also very important to me . Whether in academia or industry , generating and analyzing big data is always more productive and more fun when working with people who have different backgrounds and expertise than me . It s these type of collaborations that have provided me the opportunity to work on diverse projects , including investigating how genetic variants found across different populations contribute to human health and disease Fragoza and Das et al . Nat . Commun . 2019 , as well as uncovering new genes that may contribute to Autism Spectrum Disorder Chen and Fragoza et al . Nat . Genet . 2018 . I m always eager to share or learn about new and creative ways people are generating or utilizing biomedical data , so feel free to reach out if you ever want to chat . It may lead to another collaboration .. Technologies :

Director , Bioinformatics . Manage team of Bioinformatics Scientists responsible for analysis of viral genomes and antiviral drug resistance . Architect and develop GxP compliant software systems used to store and report sequencing results from clinical and discovery virology studies . Integrate biological assay data with patient demographics and clinical outcomes to enable correlation studies . Aid biologists with data mining , interpreting sequencing results , and data visualization Lead cross functional teams for submissions of datasets to FDA and international regulatory agencies for New Drug Applications and Drug Label Updates . Contributed to new drug approvals for treatment of SARS COV 2 Veklury , Hepatitis C Vesovi , Epclusa , Harvoni , Sovaldi , HIV Biktarvy , Genvoya , Descovy , and Stribild , and Hepatitis B Vemlidy and Viread . . Bioinformatics Team Leader responsible for development of software for clinical virology data reporting and data analysis strategies to support discovery and development of antiviral drugs . Specialize in building data pipelines for Next Generation Sequencing data analysis including de novo sequence assembly , sequence alignment , variant calling , and necessary quality control steps . Led bioinformatics projects for viral subtyping , antiviral resistance monitoring for clinical trials , vaccine immunogen sequence design , prediction of antibody sensitivity , and gene editing studies . Proven track record executing regulatory data submissions to US and other international regulatory agencies for new drug applications and clinical care quality measures : FDA , EMA EU , PMDA Japan , CFDA China , CMS Medicare Medicaid , and JCAHO . Led development of GxP software systems for reporting of clinical trial results based on FDA Guidance . Technical Expertise Programming Languages : Python3 , C , R , Proc SQL Database Development : Oracle , SQL Server , MongoDB Data Visualization : Matplotlib , Seaborn , Spotfire Cloud Platforms : AWS and Azure Web development : Flask , Jinja , RESTful services , .Net Web Forms Unit Testing : Python unittest , MSTest Source Code : Git and SVN Sequence Technologies : Illumina , Pacific Biosciences , Oxford Nanopore Phylogeny : FastTree , Garli , Phyml , Mega , FigTree . Technologies :

Cryo electron microscopy scientist . I currently work in a cryo EM core facility in Finland . My main duties are as follows : Preparing biological samples Plunge freezing and VitroJet Communicating with researchers about their projects and objectives Microscopy operation , Talos Arctica TEM Data collection and delivering results to researchers . I am passionate about microscope and imaging . Having seven years work experience in different types of electron microscopy and light microscopy , I work in an inspiring multidisciplinary team , giving cryo electron microscopy cryo EM services to university researchers and bioimaging communities . I have been lucky to complete my master 's and Ph.D. studies in renowned EM core facilities at Ghent University and University of Helsinki , where I gained advanced hands on skills in modern microscopes and imaging techniques . I have a strong interest in advanced imaging techniques , and I always search for new possibilities to expand my knowledge in microscopy . In the future , I want to become a senior electron microscopy scientist .. Technologies : CryoEM

structure

Bioinformatics Analyst 2 . . Computational Biologist Data Scientist . Technologies :

PHD Researcher . . . Technologies :

Director , Cancer Immunology and Immune Modulation . Lead a group looking to discover novel cancer therapeutics which modulate the immune system to eliminate cancers . Special focus on combination therapies with oncolytic viruses and cargos for viruses . . Effective leader for biologics and NCE projects in respiratory , cardiovascular , oncological and neurodegenerative indications Conceived and executed the use of nintedanib in IPF , leading to a registered treatment for IPF , a previously untreatable orphan indication achieved blockbuster status in 2017 Co invented two innovative drugs , nintedanib for IPF and idarucizumab dabigatran antidote , now designated Breakthrough Therapies by the FDA Extensive experience in research and early development phases of multispecific biologics , scaffolds , antibodies , antibody fragments and peptide conjugates Worked in both biotechnology and pharmaceutical industries Solid scientist with over 7000 citations in peer reviewed drug discovery related fields and numerous granted patents Specialties : Inventing novel concepts to treat human disease Solving tricky problems Discovering new science and helping lead teams of scientists to do the same Enjoys working in multidisplinary teams NCE and Biologics drug discovery Biopharmaceuticals ; Biotechnology Assessing scientific opportunities . Technologies :

antibodies;developing

Senior Research Engineer . Structural biochemical characterisation of type 4 secretion systems T4SS in gram positive bacteria . T4SS are large protein machineries that allow bacteria to exchange proteins and DNA , thereby leading to a spread in antibiotic resistance which is one of the major health problems world wide . . I have a PhD in biochemistry and am working as a senior research engineer at Ume University , Sweden . My research is currently focussed on a transport system Type 4 secretion systems that bacteria use to spread antibiotic resistance and virulence factors . General skills : I have experience in writing , public speaking , supervision , teaching , creative thinking and literature research . I am used to set up and optimize new methods and can work precisely and independently , but prefer to work as part of a team . I have also been active in various Science Outreach programs such as Forskarfredag and Soapbox Science . Laboratory skills : Cloning , optimization of expression and purification of membrane proteins and protein complexes from Escherichia coli , Saccharomyces cerevisiae and Lactococcus lactis . Protein reconstitution in proteoliposomes and nanodiscs . UV VIS absorbance spectroscopy , protein ligand binding transport studies and a wide variety of other protein activity assays . Currently doing more and more structural biology via both X ray crystallography and cryo electron microscopy .. Technologies : Xray

membrane proteins;structure

Professor . . Structural biology of protein complexes involved in cancers , protein amyloids Tau , prion , A , TMEM106B , etc . in neurodegenerative diseases , viruses , and structure guided drug discovery using cryo electron microscopy cryo EM ; Developments of new sample preparation , data collection , and image analysis 3D reconstruction algorithms and software for single particle cryo EM , correlative light and electron microscopy CLEM , and electron tomography ET .. Technologies : CryoEM

idps;proteins;small molecules;structure

Senior Scientist Drug Product Development . . Biochemist biophysicist with strong analytical skills and extensive research experience in protein peptide characterization using a wide array of biophysical and biochemical techniques . Specialties : Protein characterization , Protein analytics , Protein purification , Protein folding , misfolding and amyloid formation , stability , formulation . Technologies :

idps;peptides;proteins;characterization;formulation;stability

Senior Scientist . . Computational Biologist Data Scientist Machine Learning Engineer with 10 years experience in software development , data modeling , statistical analysis , and machine learning . Key tech skills : Python machine learning packages , PyTorch , Keras , Time Series Analysis , Natural Language Processing , SQL , R , PySpark , C , Java , Javascript , openMP , MPI , Git , Flask , REST API . Bioinformatics : Rosetta , Modeller , Amber , Gromacs , PyMol , Schrodinger , Tophat , Cufflinks , DESeq2 , Kallisto , and Salmon . Email : mails2rojan gmail.com . Technologies :

Senior Scientist . Acting project lead Alzheimer 's drug discovery July 2021 February 2022 . Project lead biologics drug discovery February 2022 present . Research on disease modifiying treatments for Parkinson 's disease and Alzheimer 's disease in early discovery to late pre clinical phase . Focused on biomarkers and development of immunoassays and cell based assays . Participating in working group for company 's long term biomarker strategy . . Neuroscientist experienced in immunoassays , biologics drug research , live cell microscopy and receptor signaling , with a strong track record in method development . I am driven by a true passion for robust and potentially life changing science , and get my energy from great team work and challenging problems . I have research experience from both Sweden and the USA , and have gained knowledge on both in vitro and in vivo pharmacology during these 10 years . An open mind and efficient prioritization combined with diligence and endurance were key to reach my goals . Colleagues value my positive , cooperative personality , dedication and open and honest communication .. Technologies :

idps

Postdoctoral Research Fellow . Mitochondrial diseases , Cryo electron microscopy , Dynamin related protein . . Technologies : CryoEM

proteins;structure

Lab . Manager Molecular Biologist . . Have an extensive track record on membrane protein , protein characterization , protein crystallography as well as enzyme production in different expression systems . Besides , have vast knowledge and experience on Enterobacteriaceae and antibiotic resistance . . Technologies : Xray

membrane proteins;structure;characterization;expression

Director . Director , Membrane Protein Sciences . . Technologies :

Scientist II . Molecular biology team leader , developing reagents to support multiple drug discovery projects from target validation to CSP . Development of expression constructs , stable cell lines and bacmam viruses . Highthroughput and targeted Taqman gene expression analysis to identify potential clinical and preclinical biomarkers and assess the validity of surrogate cellular models . Assay support for small molecule projects . New target assessment . An accomplished Research Scientist with 16 years experience in pharmaceutical drug discovery across multiple therapeutic areas , having broad knowledge and experience in research project management , leadership , problem solving , small molecule and monoclonal antibody research . Very broad appreciation of major disciplines in drug discovery with significant experience in pharmacology , cell biology , biochemistry and molecular biology , applied to both small molecule and monoclonal antibody research . Excellent people manager committed to the development of direct reports as well as providing leadership for colleagues across multiple global sites and disciplines . . Well developed networking skills , with proven team and leadership competency in global multidisciplinary programs and external collaborations . Extremely wide range of transferable technical and scientific skills enabling delivery across multiple therapeutic areas . Specialties : Molecular Biology , Assay development , Project leadership in small molecule and monoclonal antibody research . Technologies :

antibodies;proteins;small molecules;expression

Assistant Professor at University of Michigan , College of Medicine . . I am an Assistant Professor of Pharmacology at University of Michigan Medical School , and my research is focused on the elucidation of the molecular mechanisms of GPCR activation , signaling , and regulation as well as exploiting the molecular tools modulating the GPCR signaling . I have a strong background in biochemistry and structural biology and have expanded my expertise to biophysics and protein engineering during my postdoctoral period . As an experienced researcher in the field of GPCR structural biology , I laid the groundwork for the structure determination of the active state GPCRs in complex with downstream G proteins by developing an antibody fragment , scFv16 , that stabilizes the GPCR G protein complex and chimeric G proteins to impart the binding of this antibody . These molecular tools have greatly facilitated structural analysis of numerous GPCR G protein complexes across the community such as mu opioid receptor , cannabinoid receptor , and chemokine receptors by cryogenic electron microscopy . I utilized it to reveal the molecular architecture of muscarinic acetylcholine receptior 2 Go type G protein and muscarinic acetylcholine receptor 1 G11 type G protein to reveal the structural framework of G protein subtype selectivity within muscarinic receptors . In addition , I succeeded to reveal the molecular basis of the extremely high subtype selectivity of muscarinic toxin 7 , a natural snake toxin , to the target receptor muscarinic acetylcholine receptor 1 by X ray crystallography . Using my protein engineering skillset , I engineered the interface of the toxin to redirect the specificity toward another muscarinic receptor , while retaining the conformational selectivity to the inactive state and allosteric effect on the antagonist . This study demonstrates a promise of the toxin scaffold to generate novel protein molecules with unique function . These research works wouldn t have been possible without a highly collaborative team , and I recognize a crucial importance of bilateral communication between team members with different research background for the success of the project . I also realize that layers of discussion among interdisciplinary teams not only polishes the output of the project but also creates a novel view and direction for the project .. Technologies : Xray

membrane proteins;interaction;structure

Marie Sklodowska Curie Research Fellow . Functional Lipid Interactions within Membrane Proteins . . Technologies :

membrane proteins;interaction

Scientist , Computational Biology . Scientist on the Informatics and Predictive Science Team , focusing on cancer research . I focus on variational inference in the realm of computational biology . Current Master 's Student in Computational Biology at Weill Cornell . It 's a bayesian world , frequentists are just living in it . Technologies :

Assistant Director New Antibody Products . . I am really passionate about performing scientific experiments that may contribute to the understanding , improvement and instigation of cancer treatments . . Technologies :

antibodies;developing

Senior Scientist : Cresset Discovery . . PhD in Chemistry from IISc Indian Institute of Science , Bangalore , India . MBA in General Management from SIMS Symbiosis Institute of Management Studies , Pune , India . MSc in Organic Chemistry from Bangalore University , India . BSc with Physics , Chemistry and Mathematics from Bangalore University , India . Post Doctoral Fellow in Max Planck Institute , Muelheim , Germany which focused on novel catalyst design for Waker Chemi , Munich , Germany . Post Doctoral Fellow in the College of Pharmacy , University of Michigan , USA , which focused on protein modelling , docking and protein flexibility in Drug Discovery . Collaborative work experience with global pharmaceutical leaders AbbVie USA , MSD USA , Orion Finland , Takeda Japan , Novo nordisk Denmark , Debiopharma Switzerland , Inflazome UK and Grey Wolf Therapeutics UK on disease targets like Diabetes , Cancer , Obesity , Inflammation Alzheimer 's . Experienced in setting up State of the art 3D Computer Aided Drug Discovery laboratory . Power user of QM , MD and MM softwares like Spartan , Gaussian , Molsoft ICM , Schrodinger suite , MOE , OpenEye Suite , AMBER , GROMACS , PyMOL , VMD , SILCS FragMaps ; Product development , Leadership , Start up , Business Development , Health care and Crop Protection , In Licensing and Out Licensing , Fine Chemicals , Bulk Manufacturing , 3D Visualization and Modelling . 10 publications in international Journals . Inventor ship on 66 published or filed US and World patent applications and granted patents . Excellent analytical and communications skills with familiarity with pharmaceutical space . Associated Institutions : 1 Indian Institute of Science , Bangalore , India . 5 years in campus 2 University of Michigan , Ann Arbor , USA . 2 years in campus 3 Max Planck Institut f r Kohlenforschung , Muelheim , Germany . 2 years in campus 4 Bangalore University , Bangalore , India . 5 years in campus 5 Bioinformatics Institute BII , Singapore . 2 years in campus 6 Singapore Eye Research Institute SERI , Singapore . 2 years in campus 7 Symbiosis institute of Management Studies SIMS , Pune , India . 2.5 Years in campus . Technologies :

Research Fellow , Computational Biology . . . Technologies :

Scientist Bioinformatics . . . Technologies :

Research Scientist . . My research focuses on developing chemical tools to study protein function , and elucidate their role in relation to health and disease . Utilizing my background in organic synthesis and medicinal chemistry I have hands on experience within multiple projects including development of both small molecule and peptide based probes , development and SAR studies of inhibitors and PROTACs as well as enzymatic assays , protein pull down , and cell culture .. Technologies :

molecular glues;small molecules;peptides;developing

Ramalingaswamy Fellow of DBT and Faculty Scientist . Responsibilities include elevating genomics research in India in par with that in the West through training and research . My research projects include but not limited to : Studying alternative splicing in eukaryotes . Discovering biomarker for cancer using public repository of NGS data . Sequencing the genome and transcriptome of Amaranthus hypochondriacus to decipher lysine metabolic pathways in plants . Providing scalable solutions to individual investigators on cloud to maximize use of RNA seq data in the public repositories to advance research . . I have dedicated my career to applying computational solutions to solve simplify complex biological problems ranging from protein folding to personalized genomics . My current focus is in applying information from the post genome sequencing efforts to improve human health via personalized genomics and molecular breeding . Authored over 40 publications in peer reviewed journals including a book . Inventor of over 10 issued US patents involving development and application of novel algorithms for solving complex biological problems . Demonstrated ability to turn white board level concepts to marketable research tools for use in biomarker or drug discovery efforts . Specialties : Developing novel algorithms , implementing new ideas to solve bottom line problems , developing products , building scalable business model , forging collaborations , raising funds , developing marketing strategies , securing NIH grants , providing customer support , software solutions , training students . Technologies :

Permanent scientist Institut Pasteur . . Researcher in Cell biology , , Virology and Cryo CLEM and tomography , with experience in the coordination and development of scientific projects . Passionate for cryo EM advanced methods development . Excellent communication and networking skills . TECHNICAL EXPERTISE : Animal models . Mouse : E18 Dissection hippocampus and cortex . Zebrafish : cdna et mRNA micro injection . Transplantation . Live imaging of Zebrafish embryos in gastrula stage . Biochemistry and Molecular Biology . Bacterial transformation . Restriction enzyme digestion . Molecular cloning , including mRNA amplification . DNA preparation including plasmid , genomic PAC DNA . Immunoprecipitation . Polyacrylamide gel electrophoresis . Western blot . Pkdigestion , velocity gradient . CRISP CAS9 . Immunofluorescence . Wholemount zebrafish staining Culture systems . Mammalian cell lines : SHSY 5Y , CAD , MDCK , GT1 , N2A , FRT , HeLa , HEK 293 . Primary cell cultures : Cortical , hippocampal neurons , organotypic slices . DNA transfection , Lentivirus Transduction , RNA interference . Primary cell culture from embryos of zebrafish in gastrula stage . Cell culture Infection with SARS CoV2 Software and Image Analysis : ImageJ , ICY , Imaris , Adobe Premiere , Adobe Photoshop , Adobe Illustrator , Amira , Serial EM , Excel , Powerpoint , Prism6 . Microscopy . Light fluorescence microscopy : Zeiss and Leica confocal microscopy . Spinning Disk Nikon ; Cryo Electron Microscpy Tecnai 20,Thermo Fisher company , and Titan application to EMBL ; Light Sheet Microscopy and AO Light sheet , application at Janelia labs Cryo electron tomography on a TITAN CRYO EM Cell preparation for Carbon coated gold TEM grids Cryo EM samples preparation Cell Vitrification using LEICA EMGP system Cryo Fluoresence Animal Licenses Rodents .. Technologies : CryoEM

proteins;structure

Principal Scientist . Structure based drug design ADC project support . Experienced Associate Professor with a demonstrated history of working in the higher education industry . Skilled in Natural Products , Cheminformatics , Medicinal Chemistry , Biotechnology , and Chemical Biology . Strong education professional with a Ph . D focused in medicinal chemistry from Shenyang Pharmaceutical University . . Technologies :

antibodies;developing

Scientist , Structural Biology . Building a scalable cryoEM pipeline to accelerate drug discovery for GPCRs . . Excited about using cryogenic electron microscopy cryoEM to accelerate structure based drug design against challenging targets . Experienced in all aspects of the gene to structure pipeline including construct design , recombinant expression in mammalian cells , protein purification , sample optimization for structural biology , cloud computing , and model building .. Technologies :

membrane proteins;proteins;small molecules;structure

Researcher . . My main interest is the elucidation of virus host interactions . I am applying classical molecular virology in combination with fluorescence microscopy , cryo electron microscopy and functional genomics approaches to gain a deeper understanding into viral life cycles . Apart from basic virology , I also have a keen interest in wildlife medicine and one health . In addition to my research activities , I am involved in running a diagnostic laboratory and training teaching of under and postgraduate students . My main motivators are the quest for knowledge , problem solving and the optimisation of workflows and tasks . . Technologies : CryoEM

interaction;structure

Process Scientist I . . Using biokinetic , mass transfer and mixing models to scale up CHO cell culture mAb processes from geometrically dissimilar bioreactors SUBs to very large scale commercial manufacturing bioreactors . modelling scale up mAbs . Technologies :

antibodies;expression

Project Scientist . Chemistry , biomolecular simulations , numerical mathematics and IT : Method and software development for computer simulations of complex molecular systems . Developer of the AMBER molecular dynamics and ADF density functional program packages . . Scientific software developer bridging chemistry , physics , numerical mathematics and IT . Working with established and newly developed computational approaches to answer chemical questions . Experienced in teaching and student supervision at the university level . Interested in a career as leading scientist . Specialties : Fortran , Python , shell scripting , Git , MPI , performance libraries , high performance computing , GPU computing , computational chemistry , density functional theory , data analysis . Technologies :

Principal Scientist . . Experienced structural biologist focusing on ternary protein complex structures in Targeted Protein Degradation filed . Strong expertise in both X ray Crystallography and single particle cryo EM . Proven record in construct design , protein chemistry and protein ligand characterization . . Technologies : Xray;CryoEM

molecular glues;proteins;small molecules;characterization;interaction;structure

' Interdisciplinary Cancer Research ' Fellow . Fellowship Programme , co funded by the EU Framework programme 7 FP7 Marie Curie Actions . Funded Project : ' Resensitisation of chemotherapy resistant cancer cells through selective inhibition of the STAT3 signalling pathway ' . Drug Discovery , biological evaluation and preclinical development of a novel class of small molecule STAT3 inhibitors , as stand alone agents and in combination with DNA damaging chemotherapy platinum based in paired sensitive and resistant cell lines , as a means to overcome drug resistance . Design and analysis of drug combinations . Elucidation of the molecular mechanism for the observed synergistic interactions , based on the modulation of DNA damage repair by STAT3 inhibition and the elicited DNA damage response in both 2D and 3D cultures . Identification of a lead compound as a potentially clinical candidate . Extensive comparative studies with the majority of commercially available STAT3 inhibitors , including those under clinical evaluation e. g. napabucasin , TTI 101 , WP1066 , repositioned agents and agents in the pipeline of clinical stage . biopharmaceutical companies . Detailed characterisation of cell signalling perturbations and effects on downstream target genes . Discovery of two unique differentiating properties of the lead compound . It is inherently . fluorescent and its cellular uptake can be traced by live cell imaging , confocal microscopy and or . FACS . It also induces in vitro , the morphological signatures e. g. vacuolisation of recently reported , . non apoptotic cell death mechanisms paraptosis methuosis . Filing of a US provisional and a PCT patent application . Development of a novel , colorectal cancer , 3D multicellular spheroid model , for the study of ICD signatures induced in vitro , by the First in class Ruthenium Anticancer Drug KP1339 BOLD 100 . Preparation of CDAs for use with industrial partners . . Supervision of 2 M. Sc projects and training of 10 visiting scientists internships . . Drug Discovery , Drug Development , biological evaluation and preclinical development in vitro , in vivo of novel , experimental cancer therapeutics . Molecular and cellular pharmacology toxicology of clinically used as well as novel , rationally designed DNA interactive agents DNA damaging : alkylating agents , DNA Interstrand crosslinking agents , Non covalent non genotoxic DNA binding agents : polyamides , Antibody Drug Conjugates and small molecule inhibitors molecularly targeted agents . . Development of biological assays for the characterisation of drug induced DNA damage and DNA repair cellular responses in various models cell free systems , yeast mammalian human cell lines , 3D tumour spheroids , xenograft samples , patients samples . . Characterisation of drug effects and interactions between DNA damaging chemotherapeutics radiotherapy and molecularly targeted agents in 2D and 3D cultures . Cellular uptake studies of platinum based and fluorescent drugs . Identification of synthetically lethal interactions . Expert in biological assays used for regulatory purposes Comet assay , H2Ax , DNA covalent binding assays , nuclear fragmentation . Immunogenic Cell Death inducers chemistry and biology . Development of a 3D spheroid model for . the in vitro study of ICD signatures . Training in Health Risk Assessment Karolinska Institutet , the interpretation of toxicological data Toxicogenomics EMBL EBI and Adverse Outcome Pathways AOPs , JRC EU Commission , UK National Centre for the Replacement , Refinement and Reduction of Animals in Research NC3Rs . 1 US provisional and one PCT patent application on a novel class of small molecule STAT3 inhibitors . . Mentoring and supervision of 3 PhD and 20 MSc students ; SOPs , Budget management of own research grant , organisation of seminars , workshops and international meetings . Scientific dissemination : 44 published papers , 1 book chapter , 1 review , 18 Abstracts , 1 AACR Scholar in training award , 3 Lectures , Extensive postgraduate teaching , Successful grant applications , Reviewer in various journals . . Technologies :

nucleic acids;proteins;small molecules;interaction;screening

Principal Scientist . Formulation design and development . Formulation Techniques : Long acting injectable and oral formulation design : nanocrystals , micelles , liposomes , polymer drug conjugates , solid lipid nanoparticles and microspheres Formulation characterization techniques : particle size , charge , loading , stability , morphology , viscosity , surface tension and protein binding Lyophilization process development and optimization Skill of pharmaceutical applications of different stabilizers and excipients Nanoformulation subcellular trafficking and proteomics analysis Basic GMP GLP knowledge Analytical Techniques : High Performance Liquid Chromatography Liquid Chromatography Mass Spectrometry Gel Permeation Chromatography Ultraviolet Visible and Fluorescence Spectrophotometer Fourier Transform Infrared Spectroscopy Dynamic Light Scattering and Zetasizer Polyacrylamide gel electrophoresis Confocal Microscopy and SEM TEM Magnetic Resonance Imaging Cell and Animal Processing Skills : Basic cell culture technique Bioassay : Western blot , MTT , ELISA , PCR , and Immunohistochemistry Basic PK PD technique Jugular vein cannular technique Chemistry Techniques : Prodrug design and development Polymer modification Polymer drug conjugation Computer Skills : Molecular Modeling software Microsoft Word , Excel , PowerPoint and basic Internet skills Photoshop Adobe Illustrator AutoCAD EndNote Prism SPSS . Technologies : SLS DLS

antibodies;carriers;formulation;stability

Assistant Professor . . I am passionate about using cryo EM to understand how macromolecular complexes function in human health and disease . Currently , I am a faculty member at the University of Michigan who leads a laboratory that studies mechanisms of microtubule trafficking . Our main technique is cryo electron microscopy that we supplement with single molecule fluorescence and biochemical assays . Research laboratory website : https : www.lsi.umich.edu science our labs michael cianfrocco lab . Technologies : CryoEM

proteins;structure

Consutant . Advisor for younger academic and technician workers . RESEARCH PROJECTS ON : 1 . Oscillating Acoustic pressure experiments at frequency of around 1 MHz coupled with Raman and Fluorescence spectroscopy on a designed cell with protein solution for measuring fast protein folding . 2 . Focus : Construction of Iso potential surfaces of biomolecules from Quantum Mech . Calculations . 3 . ESR studies of Channel Proteins in membranes for investigating protein lipid interaction . 4 . Phase study of Bio mimetic membranes with respect to proteins and detergents . 5 . Electronic processes in the Photosynthetic complex . 6 . Studies of Surface Enhanced Raman Scattering . Research in quantum field theory and statistical physics in the first research years but has since been focused on biophysics . Here , the main field of research in the last 25 years has been molecular biophysics . Specifically , the particularly biomolecules of proteins are studied with respect of their structure , dynamics and biochemical function that are analyzed theoretically by computation methods using computer and measured experimentally by especially vibrational spectroscopy . Worked on Medical Informatics , e.g. searching for structures of HIV proteins . Recently I have undertaken an immunology project on tolerance of Tregs concerning organ transplantation using available experimental data and literature study of how to transfer Tregs to the patients of transplantation . Particular innovation activities have been starting and setting up the following activities and research collaboration with industry 1 . Prokyon Aps , for utilizing microwave radiation for biomolecules production and refinement H rsholm , DK , Closed 2008 . 2 . Structural Bioinformatics AT , a company with 12 researchers lab.tech . using Neural Networks in protein design . Bought . 3 . Consulting work and collaboration 2001 2015 with Novo Nordic , Novo zymes , Santaris Roche H rsholm and Lundbeck etc . Key words : Drug design , classical and quantum calculation of molecular structures . Technologies :

biologics;proteins;interaction;stability

Assistant Professor . My lab specializes in using cryo EM to visualize how molecular machines enact protein quality control . . Cells have extensive quality control systems to correct various mistakes . Yet , quality control can also fail , leading to diseases such as cancer and neurodegeneration . My goal is to resolve the molecular detail of cellular quality control so we can understand 1 how cells normally stay healthy ; 2 how quality control fails ; and 3 how to rescue quality control failure . In the media : http : healthcare.utah.edu publicaffairs news 2015 01 1 01 15 New Function for Proteins.php http : healthcare.utah.edu publicaffairs news 2016 11 pkd2 silent killer.php . Technologies : CryoEM

proteins;structure

VP Chemistry . . Experienced medicinal chemistry leader with a strong track record of clinical candidate delivery . VRx 3996 atinostat , AZD5363 capivasertib GSK3117391 . Accomplished manager director of CRO chemistry teams . Expertise in property based , SBDD FBDD . Additional expertise at the interface of medchem and compchem . Strong focus on project delivery and managing medchem strategies . . Technologies :

small molecules;interaction;screening

Principal Scientist Mass Spectrometry in PAT . Providing mass spectrometry support to Commercialization MMD in line , at line online . . As an accomplished leader in Mass Spectrometry and analytical chemistry , I have end to end experience from small molecule drug discovery to clinical trials and vaccine licensure . My extensive background has enabled me to successfully apply innovative analytical approaches to solve complex problems in a variety of fields . Where others see challenges , I see opportunities to challenge the status quo and implement positive changes for better scientific outcomes . My goal is to use my analytical knowledge and leadership skills within a diverse laboratory setting to solve problems and deliver quality results , while providing mentoring and coaching of technical and emotional intelligence to less experienced staff . Specialties : Applying analytical chemistry to resolve issues . Recognized expert in chromatography , automation and mass spectrometry . Applied mass spectrometry techniques to extractables and leachables , metabonomics , ion mobility , affinity selection , peptides , proteins , nucleotides , antibody drug conjugates , reaction monitoring TLC MS and ambient ionization techniques .. Technologies :

Bioinformatics Manager . . . Technologies :

Director Of Operations , SCSC . . Electron Microscopy Cryo ET Cryo EM Array Tomography SEM 3D Volume SEM CLEM Correlative Light and Electron Microscopy Variable Pressure VP SEM application Hydrogel and Biomaterial Imaging Synchrotron XRF application to Biology EM Technique Development SEM and TEM Visualization : Light and Electron Microscopy Microbial Biofilms Bio energy Plant and Microbial Sciences and Interfaces Monoterpene Essential Oils Metabolism Gas chromography Complexity Theory and Fractal Analysis Biology Teaching in Higher Education Specialties : Electron Microscopy Imaging Techniques Biofilms Biofuels Assay and Protocol development . Technologies : CryoEM

Scientist I Computational Biology and Machine Learning . . I 'm a recent Computational Biology PhD graduate from MIT . I 'm passionate about making sense of large multi modal datasets and using those insights in translational settings . My graduate work consisted of developing and applying graphical and machine learning algorithms to integrate large sequencing datasets and understand the causes of ALS .. Technologies :

Computational Biologist . . I am a data scientist and statistician working in the field of genomics and transcriptomics . I am currently a computational biologist in Biogen . I am working on developing statistical and machine learning methods for applications ranging from bulk DNA RNA sequencing , scRNA seq data , and multi omics data integration . I was a postdoctoral fellow in the Department of Bioinformatics Computational Biology , The University of Texas MD Anderson Cancer Center . I have formal training in mathematics , biomedical engineering and statistics . I obtained Bachelor degree in Applied Mathematics at Xi an Jiaotong University in China , 2011 . I obtained PhD in Biomedical Engineering at Tulane University on 2016 .. Technologies :

VP , Digital Lab Systems . . Bioinformatics experience 20 years at industry leading institutions Strong project , management , communication , and organizational skills Management and control of large budgets up to 2 million Management of large staff up to 20 people including developers and system administrators Extensive software design and development experience Infrastructure design , development , and implementation Application of software engineering methodologies Ability to work on multiple concurrent projects Ability to communicate with all levels of an organization Specialties : Informatics Functions : Systems analysis , Project management , System administration , Network administration , Database administration , Website administration , Software development Domain knowledge : Next generation sequencing , Genetics , Proteomics , LIMS Bioinformatics Software : CASAVA , BWA , BFast , GATK , TopHat , Bioconductor Programming Languages : Perl , Ruby , PHP , SQL Oracle , Sybase , MYSQL , JAVA Operating Systems : UNIX Solaris , Linux , Microsoft Windows , Macintosh High performance computing : Moab Torque , high performance storage , large compute clusters . Technologies :

VP Research , Pharmacokinetics and Drug Metabolism . . . Technologies :

Lead Staff Scientist , DNA Origami Research . Lead the design and the development of DNA Origami reagents for single protein detection platform . I 'm a bioengineer and software developer specialized in DNA origami design and protein engineering . I develop DNA origami tools for various biological applications including high throughput cryo EM studies of small proteins and RNAs . I also develop software that aid in DNA origami and protein design , and for cryo EM image processing .. Technologies : CryoEM

Visiting Researcher . . Utilizing correlative super resolution light and cryo electron microscopy to investigate the role of endolysosomal pathways in the intracellular delivery of therapeutics .. Technologies : CryoEM

carriers;structure

USP DSP Scientist . at MSD Oss . Experienced Biomedical Engineer with a demonstrated history of working in the pharmaceuticals industry . Skilled in Upstream Processing , Monoclonal antibody production , Cell culture , Cell biology , Bioreactor technology and Lab automation . Strong research professional with a Master of Science MSc . Technologies :

biologics;expression;quality

Research Scientist . . Molecular biologist with proven expertise and 13 years of experience in biochemistry molecular biology chemical biology structural biology research . Now determined and exploring opportunities to learn , lead and excel in industrial set up . I have identified , explored and established functions of several noble proteins and the signaling molecules involved in RNA damage and repair and , bacterial defense against phage . Demonstrated expertise in a Protein biochemistry : protein cloning , expression , biochemical studies and , structural studies using SPR , X ray crystallography and Cryo EM . b NGS : RNA Seq library preparation and data analysis . Proven ability to work , train , and lead the team to achieve projects goal on time . I had great experience working with and leading people from diverse background . I have planned , executed , troubleshoot and successfully finished projects within deadline in team set up and alone . Contributed to multiple articles and grants writing which were funded .. Technologies : Xray;CryoEM;SPR

proteins;interaction;structure

Bioinformatics Analyst III . . . Technologies :

Staff Bioinformatics Pipeline Development Engineer . . Bioinformatics Applications 1 TNBCtype : A subtyping tool for triple negative breast cancer . https : cbc.mc.vanderbilt.edu tnbc 2 MitoSeek : A tool to perform high throughput mitochondria sequencing analysis.https : github.com riverlee MitoSeek . 3 RNASeqDEPipeline : A integrated pipeline to perform RNA Seq differential gene expression analysis . https : github.com riverlee RNASeqDEPipeline . 4 ViewFusion : A visualizing tool for gene fusions . https : github.com riverlee viewFusion . 5 DOSim : An R package to calculate similarity between diseases based on Disease Ontology . http : cran.r project.org web packages DOSim index.html . 6 DO.db : A set of annotation maps to describe the entire Disease Ontology . http : www.bioconductor.org help bioc views release data annotation html DO.db.html . 7 Risk FunmiRSNP : A web based tool to detect , analyze and annotate disease risk miRNA polymorphisms from large scale dataset . http : 210.46.85.150 platform riskfunmirsnp . Skill set Computer skills Operating Systems : Linux , Mac OS , MS Windows . Programming Languages : Perl , R , Java , Shell , Python , Matlab . Database and Web programming : Apache MySQL PHP , Ajax , Drupal , Joomla , jQuery . Others : Wiki , Sweave , Bioconductor , Bioperl , Weka , Spider , Cytoscape , Illustrator , and Latex . Bioinformatics skills Next Generation Sequencing Analysis : Reads Quality Control , Mapping and Evaluation , Gene Expression Quantification and Gene Fusion Detection for RNA Seq , Peak Calling , Annotation and Motif Analysis for Chip Seq , Variants Detection and Functional Prediction for Exome Seq , Peak Calling and Footprint Analysis for ATCT Seq . Microarray Analysis : Differential Expression and Co expression Network Analysis . Machine learning techniques : Classification SVM , KNN , Decision Tree , Clustering . Statistical analysis : Linear Regression , Survival Analysis , and Principal Component Analysis PCA . Genetics Analysis : Genome Wide Association Study GWAS , Hardy Weinberg Principle Testing .. Technologies :

Principal Scientist . . 20 yrs experience in biophysical characterization and stability evaluation of proteins . During the last 15 years my research activities have been related to early stage biopharmaceutical drug development including antibody format variant screening . Experienced in identification of mAb variant selection criteria related to stability and biophysical properties , as well as in formulation screening for optimized stability and viscosity profiles . Collaborative across drug development areas : Discovery engineering , early CMC analysis and formulation , patent , and clinical teams .. Technologies :

antibodies;biologics;proteins;characterization;formulation;stability

Founder and Director , Centre for Targeted Protein Degradation CeTPD . . . Technologies :

molecular glues;interaction

Senior Scientist . . Biophysicist structural biologist with 10 years of research experience . I am interested in studying the structure function relationship of ion channel and membrane transporters using a multitude of techniques including X ray crystallography , Cryo electron microscopy and Molecular dynamics simulation . Proven track record in teaching , mentoring , and leading scientific collaborations .. Technologies : Xray;CryoEM

membrane proteins;structure

Principal Scientist CMC USP and Host Creation . . I am passionate about Biotechnology and the production of next gen therapeutics . I am currently engaged as a Principal Scientist CMC Host Creation and Upstream processing . In addition to managing day to day CMC activities within these skill teams , I am also involved in managing the CMC Nanobody development activities and tech transfer . From my academic experience , I have a strong background in Recombinant protein production strain engineering , expression optimization , protein purification and characterization , Molecular Biology and Glycobiology . I am a research professional with a strong drive to learn and integrate new technologies , always eager to take on new challenges . . Technologies :

antibodies;characterization;developing;expression

Head Preclinical Product Development . More than 25 years of experience in development of antibodies from research till clinical phase II studies . Actively involved in the start up of several biotech companies . At Ablynx I was the first employee , and project manager for the discovery and pre clinical early clinical development of Caplacizumab . Caplacizumab is approved as a first in class treatment for acquired thrombotic thrombocytopenic purpura aTTP . This project resulted to the acquirement of Ablynx by Sanofi for 3 . 9 billion euros . At argenx I was also one of the first employees and project manager for the discovery and pre clinical clinical development till phase I of Cusatuzumab . This project entered an exclusive global collaboration and license agreement with Cilag GmbH International , an affiliate of Janssen . Cusatuzumab is currently in development in combination study with Vidaza for newly diagnosed , elderly patients with acute myeloid leukemia AML and high risk myelodysplastic syndrome MDS who are unfit for chemotherapy . . I was also project leader for ARGX 117 , ARGX 119 and ARGX 120 . Currently I am heading all preclinical programs from lead optimization till IND submission . At Staten I did the discovery and helped with the pre clinical development of STT 5058 , a monoclonal antibody targeting Apoc3 . This antibody entered into a collaboration with Novo Nordisk who provides funding and support for Staten to develop its lead asset STT 5058 for treatment of dyslipidaemia . . At Catalym I was SVP for CMC , bioanalytics and toxicology . I worked for four years at the university of Brussels developing the Nanobody platform which lead to the establishment of Ablynx , where I was the first employee . I was inventor and project leader for Caplacizumab , the first and only Nanobody approved today . . After that I joined argenx where I was project leader for ARGX 110 , ARGX 117 , ARGX 119 and ARGX 120 . I work since 4 years as an independent consultant supporting argenx , Citryll , Catalym and Staten with the preclinical development of their antibodies . . Currently I am heading all preclinical programs at argenx taking antibodies from lead optimisation until IND filing . . Technologies :

antibodies;developing

Visiting Junior Researcher BioLAB Program . Project : Solving the structure of IGF 1 : IGFBP 3 : ALS complex using cryo EM My one year internship work is devoted to assembling IGF 1 : IGFBP 3 : ALS ternary complex , and using cryogenic electron microscopy and RELION to solve its structure . Methods : Cryo EM , protein purification , protein refolding , HEK cells culture , Sf 9 culture , bacteria culture , Western blotting , site directed mutagenesis PCR . . On the verge of science and business . Success driven scientist with an entrepreneurial mind and deep interest in business . Excellent problem solving and project management skills . Proved both as a team player and a leader . Seeking to utilise my scientific background and further develop my business acumen . Specialized in bioinformatics and structural biology .. Technologies : CryoEM

proteins;structure

Principal bioinformatics research scientist . . . Technologies :

Digital Research Environment Lead . . PMP certified Project Manager with extensive experience in Biomedical Informatics led multi disciplinary teams across global sites . Successful collaborations with partners customers in academia and industry . Expertise in translational informatics , genomic and NGS data management , integration , visualisation and analysis . Particularly interested in the advancement of translational research to improve diagnostics and treatment of patients . Specialties : Project Programme management and team leadership Biomedical informatics strategy and systems linking clinical and genetic omics data Bioinformatics , cancer genomics and Next Generation Sequencing NGS External collaborations with partners customers User interfaces and visualisation . Technologies :

Scientist . . I have a broad scientific profile from my Nanoscience Education and Ph.D. in an interdisciplinary group , combining nanomaterials with protein chemistry and biophysics . My research interests are in the field of G protein coupled receptor GPCR biology . In particular , I find it fascinating how new insights in receptor function can guide rational drug design for the development of novel pathway selective compounds with reduced side effects . My expertises are within quantitative characterization of GPCRs using fluorescence detection methods and surface sensitive techniques such as Surface Plasmon Resonance . I m motivated by starting up and developing new and innovative ideas ; with this positive mindset , I established methods for GPCR purification , stabilization and characterization in our laboratory by visiting and transferring know how from collaborators in USA and Europe . Technologies : SPR

membrane proteins;small molecules;characterization;interaction

Co founder Managing Director ATEM Structural Discovery . ATEM Structural Discovery provides innovative cryo EM solutions to pharmaceutical and biotechnological industries . We support the most challenging discovery and quality control efforts and allow the structural elucidation of previously unfeasible drug targets . . A cryo EM Scientist , founder and technology enthusiast focused on innovating method development and advancing the most powerful , fully integrated cryo EM platform in the pharmaceutical and biotechnological industry with ATEM . At the forefront of leveraging the powers of cryo EM to understand how macromolecular complexes and proteins function , malfunction in disease and how they interact with small molecule or biological drug candidates . Develops an integrated cryo EM platform to extract more empirical data from highly complex 3D structural models . Published in top peer reviewed journals Science , Nature , and Cell ATEM is at the forefront of the cryo EM revolution in structural biology . Our unique and integrated platform incorporates cryo EM optimised biochemical processes with high end data acquisition hardware and data processing augmented by continuous machine learning enhancements . Our next gen proprietary software suite allows us to deliver more detailed , high resolution 3D structural models with higher accuracy and faster turnaround times . To find out more about ATEM , visit our website at : www.atem.bio or contact me at karl.bertram atem.bio . Technologies : CryoEM

small molecules;interaction;structure

Ph.D. Researcher . Reconstitution of Cell Polarity and Morphogenesis . . I am a researcher with experience in experimental and computational biology . My interest lies in the development of cell based diagnostics and therapeutics . I believe , with the current advances in protein engineering and genetic circuit design , we can repurpose cellular functions to sense molecular markers and selectively actuate therapeutic response against diseased cells . With this aim , I aspire to pursue a career in the field of Synthetic Biology .. Technologies :

Senior Scientist Computational Biology . Analysis of high throughput sequencing data directed at clinical biomarker identification and understanding mechanisms of resistance to targeted therapy in an oncology setting . NGS data analysis pipeline development for variant calling and transcriptomic analysis utilizing tools such as GATK , varscan2 , bwa , bowtie , RSEM , muTect , etc . Development of models utilizing gene expression profiling for identification of prognostic biomarkers and response to ibrutinib . Genomic copy number SNP analysis of data from clinical samples . Secreted protein analysis from patient serum . Longitudinal analyses in support of establishing clinical biomarkers for future studies . Established a computational infrastructure in support of bioinformatics . Computational chemistry MD simulation , free energy perturbation , virtual compound screening , docking in support of new compound discovery and lead prioritization Interacting closely with clinical operations as part of study management teams . Selected Commercial Tools and Programming Languages : C , Perl , and R programming in a Unix Linux environment ; NGS data analysis pipeline development using tools such as GATK , Varscan2 , bwa , RSEM , MuTect , bowtie , etc . ; Integrative analysis using OmicSoft ArrayStudio , Schrodinger Suite ; relational database design and management , SQL ; Proteomic data analysis : Progenesis , Scaffold Sorcerer , Crux ; VMD NAMD molecular dynamics and modeling software ; visualization of high dimensional data sets ggobi and others ; Statistical analyses using JMP , Partek ; Automation and high throughput software development .. Technologies :

Scientist Vaccine Development . . Dedicated , self motivated , flexible , quick learner and deadline driven biotech professional with extensive training in upstream process development and production cell culture , cell biology , bioassay as well as downstream process development and production protein purification , antibody purification , biochemical and biophysical characterization in academic setup . I have obtained intensive 5 days long in person training on industry standard GMP compliance .. Technologies :

antibodies;biologics;characterization;stability

Research Professional . . My interests are centered on studying the structure function relationship of macromolecules . I employ X ray diffraction methods and Cryo electron microscopy to gain understanding of the structural basis of the mechanism of action of and inter relationships of biological macromolecules .. Technologies : Xray;CryoEM

proteins;structure

Scientist . . Graduate student peptide chemist with 4 years of experience in short to medium length 20 50 amino acids long peptide synthesis , purification , characterization and self assembly analysis . Skilled in automated solid phase peptide synthesis SPPS , preparative and analytical high performance liquid chromatography HPLC , matrix assisted laser desorption ionization time of flight mass spectroscopy MALDI TOF MS , instrument maintenance , UV Vis and fluorescence spectroscopy , circular dichroism spectroscopy , transmission electron microscopy TEM , cryogenic electron microscopy cryo EM , X ray diffraction XRD .. Technologies : Xray;CryoEM;CD

peptides;characterization

Advanced Workflow Specialist Nanotechnology . Training and workflow design for electron microscopy experiments . . Currently providing training and experimental design for electron microscopy , including sample preparation methods , at Leica Microsystems . My postdoctoral work at the National Institute for Neurological Disorders and Stroke NINDS focused on synaptic vesical trafficking with room temperature TEM and HPF sample preparation . During my doctoral training at Case Western Reserve University , I studied macromolecular structures with cryo EM and molecular dynamics simulations .. Technologies : CryoEM

proteins;structure

Principal Research Scientist . In Department of Protein and Peptide Biophysics , I 'm have implemented and optimizing our state of the art automation platform for high throughput biophysical characterization of proteins and peptides . The automated platform integrates all steps from liquid dispense , incubation , analytical instruments and data analysis , required for efficient high throughput biophysical analysis of protein formulations . I am involved in a number of diabetes related projects , where I employ techniques such as MFI , DLS , ThT fluorescence , SEC HPLC and CD spectroscopy to guide selection of improved API protein candidates and the development of stable formulations . . I consider myself a multidisciplinary biotechnology professional capable of tackling a variety of challenges in biotechnology and biophysics . In addition , I have a strong background in computer programming Python , Javascript , C , VB.net , Delphi , Java and Assembler , which I have used to develop software for rapid analysis of organized data , Lab Automation , and automated computer vision analysis of animal model behaviour . My academic career has been focused on study protein folding , misfolding and aggregation . I have a solid foundation in molecular biology from my masters where I developed Phage Display techniques for directed evolution of proteins with increased folding stability . I have strong expertise in protein biophysics from detailed doctoral studies of Amyloid like protein fibrils using glucagon model system . An lastly , I have a detailed knowledge about the genetic pathways of aging and aging related diseases from studies on the roundworm C. elegans as well as strong expertise in the use of various microscopy techniques from my post doctoral studies in the Morimoto lab at Northwestern University . At the small biotech startup , ilochip A S , I was working with an interdisciplinary team of engineers and scientists to develop a generic device for genetic detection analysis of airborne pathogens . I found this combination of molecular biology , electrochemistry , micro fluidics , electronics and computer software to be a very interesting challenge . Specialties : Organisms C. elegans , B. Thurengensis , E. coli , Bacteriophage M13 Protein Biophysics Folding , Particle analysis , aggregation amyloid , Lab Automation HTS , Lab on chip , Molecular Biology PCR , qPCR , RT PCR , cloning , Phage Display , Spectroscopy Fluorescence , Circular Dichroism , FT IR , NMR , Electrochemical Impedance , Pulsed Voltammetry , Microscopy LSM , FRET , ImageJ , MFI Programming : Python , Javascript , C .net , MongoDb , Borland Delphi , VB.net , Java , Microsoft Excel VBA , Assembly language 6502 and 680x0 .. Technologies : SLS DLS;CD;NMR;FRET

peptides;proteins;characterization;formulation;screening;stability

Senior Manufacturing Manager . . I am experienced in biochemical and molecular cell biological methods used in research and development of bio pharmaceuticals and diagnostics . For example construct design and protein expression USP , protein purification of soluble and membrane proteins DSP , biochemical analysis , ITC , structural biology , immunohistochemistry and confocal microscopy . Furthermore , I have organised international meetings , presented at conferences , lectured medical students and negotiated pricing for laboratory equipment . The methods I have used in particular include : Molecular genetics restriction cloning , PCR , DNA purification , Sequence analysis after Sanger sequencing etc . Bacterial and human cell culture Protein over expression Automated protein purification SEC , IMAC and IEX together with KTA FPLC of soluble and membrane proteins SDS PAGE , Western Blot , BN PAGE Preparation and use of various in vitro translation and transcription extracts siRNA knockdown experiments CRISPR Cas Confocal fluorescence microscopy Preparation of liposomes , proteoliposomes and inverted inner membrane vesicles from E.coli ITC some MST Site directed cross linking Protein modifications via maleimide coupling Other experience : Negotiated pricing and organised instrument demonstrations Managed ordered laboratory consumables and maintained equipment Contributed to setting up a new lab Co ordinated practical courses ELISA technique for up to 30 as team leader and lecturer Supervised several students and their degree projects Organised the SGBM retreat 2013 and EBEC2012 Student speaker of the IRTG 1478 2011 12 Contributed to research conferences meetings Collaborated with other research groups Presented my work to peers Contributed to scientific articles in peer reviewed journals . Technologies : ITC;MST

biologics;membrane proteins;developing;interaction